16,299 results match your criteria American journal of respiratory and critical care medicine[Journal]


Noninvasive Ventilation Use in Critically Ill Patients with Acute Asthma Exacerbations.

Am J Respir Crit Care Med 2020 Jul 14. Epub 2020 Jul 14.

University of Colorado Denver School of Medicine, 12225, Pulmonary Sciences and Critical Care Medicine, Aurora, Colorado, United States.

Rationale: Non-invasive ventilation decreases the need for invasive mechanical ventilation and mortality among patients with chronic obstructive pulmonary disease but has not been well studied in asthma.

Objective: To assess the association between non-invasive ventilation and subsequent need for invasive mechanical ventilation and in-hospital mortality among patients admitted with asthma exacerbation to the intensive care unit.

Methods: We performed a retrospective cohort study using administrative data collected during 2010-2017 from 682 hospitals in the United States. Read More

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http://dx.doi.org/10.1164/rccm.201910-2021OCDOI Listing

Single-cell RNA Expression Profiling of ACE2, The Receptor of SARS-CoV-2.

Am J Respir Crit Care Med 2020 Jul 14. Epub 2020 Jul 14.

Tongji University, 12476, Shanghai, China;

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http://dx.doi.org/10.1164/rccm.202001-0179LEDOI Listing

Initiating Pharmacologic Treatment in Tobacco-Dependent Adults. An Official American Thoracic Society Clinical Practice Guideline.

Am J Respir Crit Care Med 2020 Jul;202(2):e5-e31

Current tobacco treatment guidelines have established the efficacy of available interventions, but they do not provide detailed guidance for common implementation questions frequently faced in the clinic. An evidence-based guideline was created that addresses several pharmacotherapy-initiation questions that routinely confront treatment teams. Individuals with diverse expertise related to smoking cessation were empaneled to prioritize questions and outcomes important to clinicians. Read More

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http://dx.doi.org/10.1164/rccm.202005-1982STDOI Listing

COVID-19: How Do We Stay Safe?

Am J Respir Crit Care Med 2020 Jul 10. Epub 2020 Jul 10.

University of California San Diego, 8784, La Jolla, California, United States.

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http://dx.doi.org/10.1164/rccm.2020C12DOI Listing

Fetal Origins of Asthma: A Longitudinal Study from Birth to Age 36 Years.

Am J Respir Crit Care Med 2020 Jul 10. Epub 2020 Jul 10.

University of Arizona, Department of Pediatrics, Tucson, Arizona, United States.

Rationale: Deficits in infant lung function - including the fraction of expiratory time to peak tidal expiratory flow to total expiratory time (tPTEF/tE) and maximal expiratory flow at functional residual capacity (V̇maxFRC) - have been linked to increased risk for childhood asthma.

Objectives: To examine the individual and combined effects of tPTEF/tE and V̇maxFRC in infancy on risk for asthma and abnormalities of airway structure into mid-adult life.

Methods: 180 participants in the TCRS birth cohort had lung function measured by the chest-compression technique in infancy (mean age±SD: 2. Read More

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http://dx.doi.org/10.1164/rccm.202001-0194OCDOI Listing

RV Infections in Asthmatics Increase ACE2 Expression and Cytokine Pathways Implicated in COVID-19.

Am J Respir Crit Care Med 2020 Jul 10. Epub 2020 Jul 10.

University of Arizona Arizona Health Sciences Center, 12217, Tucson, Arizona, United States.

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http://dx.doi.org/10.1164/rccm.202004-1343LEDOI Listing

The Association Between Discharge Delay from Intensive Care and Patient Outcomes.

Am J Respir Crit Care Med 2020 Jul 10. Epub 2020 Jul 10.

The Alfred Hospital, The Department of Intensive Care Medicine, Prahran, Victoria, Australia.

Rationale: ICU discharge delay occurs when a patient is considered ready to be discharged but remains in the ICU. The effect of discharge delay on patient outcomes is uncertain.

Objectives: To investigate the association between discharge delay and patient outcomes including hospital mortality, readmission to ICU and length of hospital stay after ICU discharge. Read More

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http://dx.doi.org/10.1164/rccm.201912-2418OCDOI Listing

The Effect of Sleep Apnea on Cardiovascular Events in Different Acute Coronary Syndrome Phenotypes.

Am J Respir Crit Care Med 2020 Jul 10. Epub 2020 Jul 10.

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain, Madrid, Spain.

Rationale Obstructive sleep apnea (OSA) is associated with increased cardiovascular disease (CVD) risk. Conversely, OSA has not been shown to increase recurrent cardiovascular events in acute coronary syndrome (ACS) patients. This lack of homogeneity could suggest that the deleterious effect of OSA and its contribution to CVD could depend on specific patient profiles. Read More

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http://dx.doi.org/10.1164/rccm.202004-1127OCDOI Listing

A New Role for CXCL4 in RSV Disease.

Am J Respir Crit Care Med 2020 Jul 9. Epub 2020 Jul 9.

National Heart & Lung Institute, Respiratory Medicine, London, United Kingdom of Great Britain and Northern Ireland;

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http://dx.doi.org/10.1164/rccm.202006-2154EDDOI Listing

Impact of Effective Global Tuberculosis Control on Health and Economic Outcomes in the United States.

Am J Respir Crit Care Med 2020 Jul 9. Epub 2020 Jul 9.

Stanford University, 6429, Department of Medicine, Palo Alto, California, United States.

Rationale: Most United States residents who develop tuberculosis were born abroad, and US TB incidence is increasingly driven by infection risks in other countries.

Objectives: To estimate the potential impact of effective global TB control on health and economic outcomes in the United States.

Methods: We estimated outcomes using linked mathematical models of TB epidemiology in the United States and migrants' birth countries. Read More

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http://dx.doi.org/10.1164/rccm.202003-0526OCDOI Listing

Pulmonary Microvascular- Changes in Adult Survivors of Prematurity: Utility of DCE MRI.

Am J Respir Crit Care Med 2020 Jul 8. Epub 2020 Jul 8.

University of Wisconsin, Madison, Wisconsin, United States;

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http://dx.doi.org/10.1164/rccm.202002-0344LEDOI Listing

Sub-Clinical AKI is AKI and Should not be Ignored.

Authors:
Jay L Koyner

Am J Respir Crit Care Med 2020 Jul 8. Epub 2020 Jul 8.

University of Chicago, 2462, Section of Nephrology , Chicago, Illinois, United States;

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http://dx.doi.org/10.1164/rccm.202006-2239EDDOI Listing

Pulmonary Arterial Hypertension and Sex in the Right Ventricle - It is an Interesting Picture!

Am J Respir Crit Care Med 2020 Jul 8. Epub 2020 Jul 8.

VA Med Ctr, Cardiology 111C, Minneapolis, Minnesota, United States.

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http://dx.doi.org/10.1164/rccm.202006-2147EDDOI Listing

Paraseptal Emphysema: From the Periphery of the Lobule to Center of the Stage.

Authors:
Alejandro A Diaz

Am J Respir Crit Care Med 2020 Jul 8. Epub 2020 Jul 8.

Brigham and Women's Hospital, 1861, Medicine, Boston, Massachusetts, United States;

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http://dx.doi.org/10.1164/rccm.202006-2138EDDOI Listing

Long Noncoding RNA TYKRIL Plays a Role in Pulmonary Hypertension via the p53-Mediated Regulation of PDGFRβ.

Am J Respir Crit Care Med 2020 Jul 7. Epub 2020 Jul 7.

Max Planck Institute for Heart and Lung Research, 28258, Department of Lung Development and Remodeling, Bad Nauheim, Germany.

Rationale: Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Their role in pulmonary arterial hypertension (PAH) remains to be explored.

Objectives: To elucidate the role of tyrosine kinase receptor inducing lncRNA (TYKRIL) as a regulator of p53/platelet-derived growth factor receptor β (PDGFRβ) signaling pathway and to investigate its role in PAH. Read More

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http://dx.doi.org/10.1164/rccm.201910-2041OCDOI Listing

Development and Initial Validation Analyses of the Living with Idiopathic Pulmonary Fibrosis (L-IPF) Questionnaire.

Am J Respir Crit Care Med 2020 Jul 7. Epub 2020 Jul 7.

Endpoint Outcomes, 455680, Boston, Massachusetts, United States.

Rationale: Several new drugs for idiopathic pulmonary fibrosis (IPF) are in development. Tools are needed to assess whether these drugs benefit patients on outcomes that matter most to them. Health-related quality of life (HRQL) is one such outcome. Read More

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http://dx.doi.org/10.1164/rccm.202002-0415OCDOI Listing

COVID-19 Clinical Trials: Unravelling a Methodological Gordian Knot.

Am J Respir Crit Care Med 2020 Jul 7. Epub 2020 Jul 7.

The University of Manchester, 5292, Division of Infection, Immunity and Respiratory Medicine, Manchester, United Kingdom of Great Britain and Northern Ireland.

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http://dx.doi.org/10.1164/rccm.202005-1942EDDOI Listing

On Genetics, Lung Developmental Biology and Adult Lung Function.

Am J Respir Crit Care Med 2020 Jul 7. Epub 2020 Jul 7.

University of Arizona, Tucson, Arizona, United States.

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http://dx.doi.org/10.1164/rccm.202006-2123EDDOI Listing

Simplifying Rifapentine Dosing for Tuberculosis Treatment and Prevention.

Authors:
Anthony T Podany

Am J Respir Crit Care Med 2020 Jul 7. Epub 2020 Jul 7.

University of Nebraska Medical Center, 12284, Omaha, Nebraska, United States;

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http://dx.doi.org/10.1164/rccm.202006-2144EDDOI Listing

Emerging Complexity in the Biomarkers of Exacerbation Prone Asthma.

Am J Respir Crit Care Med 2020 Jul 6. Epub 2020 Jul 6.

Amsterdam UMC -AMC Campus, 26066, Pulmonology, F5-152, Amsterdam, Netherlands.

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http://dx.doi.org/10.1164/rccm.202005-2004EDDOI Listing

COVID-ARDS Clarified: A Vascular Endotype?

Am J Respir Crit Care Med 2020 Jul 6. Epub 2020 Jul 6.

University of Pennsylvania School of Veterinary Medicine, 70736, Philadelphia, Pennsylvania, United States.

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http://dx.doi.org/10.1164/rccm.202006-2598LEDOI Listing

Increased Platelet Aggregation in Children and Adolescents with Sleep Disordered Breathing.

Am J Respir Crit Care Med 2020 Jul 6. Epub 2020 Jul 6.

Women's and Children's Hospital Adelaide, 6053, Respiratory and sleep Medicine, Adelaide, South Australia, Australia.

Objective: Sleep disordered breathing (SDB) is associated with increased vascular resistance in children and adults. Persistent increased vascular resistance damages vascular endothelial cells-a marker of which is increased platelet activation. This study compared whole blood impedance platelet aggregation in children diagnosed clinically as SDB warranting adenotonsillectomy and healthy controls. Read More

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http://dx.doi.org/10.1164/rccm.201911-2229OCDOI Listing

Do Plasticizers within the Indoor Environment Increase Airway Allergen Responsiveness?

Am J Respir Crit Care Med 2020 Jul 6. Epub 2020 Jul 6.

Umeå University, Dept of Public Health and Clinical Medicine, , Umea, Sweden;

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http://dx.doi.org/10.1164/rccm.202005-2048EDDOI Listing

Equilibrium Angiotensin Metabolite Profiling in Patients with Acute Respiratory Distress Syndrome Indicates Angiotensin Converting Enzyme Inhibition.

Am J Respir Crit Care Med 2020 Jul 6. Epub 2020 Jul 6.

Medical University of Vienna, 27271, Dept. of Anaesthesia, Critical Care and Pain Medicine, Vienna, Austria;

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http://dx.doi.org/10.1164/rccm.201912-2504LEDOI Listing

Targeting p16 Promotes Lipofibroblasts and Alveolar Regeneration After Early Life Injury.

Am J Respir Crit Care Med 2020 Jul 6. Epub 2020 Jul 6.

INSERM U955 , Département de Physiologie, Hôpital Henri Mondor, AP-HP, DHU A-TVB France, Creteil, France;

Rationale: Promoting endogenous pulmonary regeneration is crucial after damage to restore normal lungs and prevent the onset of chronic adult lung diseases.

Objectives: To investigate whether the cell-cycle inhibitor p16 limits lung regeneration after newborn bronchopulmonary dysplasia (BPD), a condition characterized by the arrest of alveolar development, leading to adult sequelae.

Methods: We exposed p16 -/- and p16 ATTAC transgenic mice to post-natal hyperoxia, followed by pneumonectomy of the p16 -/- mice. Read More

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http://dx.doi.org/10.1164/rccm.201908-1573OCDOI Listing

Tissue Doppler Imaging of the Diaphragm in Healthy Subjects and Critically Ill Patients.

Am J Respir Crit Care Med 2020 Jul 2. Epub 2020 Jul 2.

"Papageorgiou" General Hospital, Intensive Care Unit, Thessaloniki, Greece.

: Tissue Doppler Imaging (TDI) is an echocardiographic method that measures the velocity of moving tissue. : We applied this technique to the diaphragm to assess the velocity of diaphragmatic muscle motion during contraction and relaxation. : In 20 healthy volunteers diaphragmatic TDI was performed to assess the pattern of diaphragmatic motion velocity, measure its normal values and determine the intra- and inter-observer variability of measurements. Read More

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http://dx.doi.org/10.1164/rccm.201912-2341OCDOI Listing

Relative Hypotension and Adverse Kidney-related Outcomes Among Critically Ill Patients with Shock- A Multicenter Prospective Cohort Study.

Am J Respir Crit Care Med 2020 Jul 2. Epub 2020 Jul 2.

The Canberra Hospital, Intensive Care Unit, Woden (Canberra) , Australian Capital Territory, Australia.

Rationale: There are no prospective observational studies exploring the relationship between relative hypotension and adverse kidney-related outcomes among critically ill patients with shock.

Objectives: To investigate the magnitude of relative hypotension during vasopressor-support among critically ill patients with shock, and to determine if such relative hypotension is associated with new significant acute kidney injury (AKI) or major adverse kidney event (MAKE) within 14 days of vasopressor-initiation.

Methods: At seven multidisciplinary ICUs, 302 patients, aged ≥40 years, requiring ≥4 hours of vasopressor-support for non-hemorrhagic shock, were prospectively enrolled. Read More

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http://dx.doi.org/10.1164/rccm.201912-2316OCDOI Listing

Chronic Effects of High Fine Particulate Matter Exposure on Lung Cancer in China.

Am J Respir Crit Care Med 2020 Jul 2. Epub 2020 Jul 2.

Chinese Academy of Medical Sciences & Peking Union Medical College Fuwai Hospital, 34736, Xicheng District, China.

Rationale: Limited cohort studies have evaluated chronic effects of high fine particulate matter (PM) exposure on lung cancer.

Objectives: To investigate the response pattern of lung cancer associated with high PM exposure.

Methods: A Chinese cohort of 118,551 participants was followed up from 1992 to 2015. Read More

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http://dx.doi.org/10.1164/rccm.202001-0002OCDOI Listing
July 2020
12.996 Impact Factor

Ventilator Sharing During Shortages: A Siren's Song?

Am J Respir Crit Care Med 2020 Jul 1. Epub 2020 Jul 1.

St Michael's Hospital in Toronto, Li Ka Shing Knowledge Institute, Keenan Research Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1164/rccm.202006-2438EDDOI Listing

A Novel Viral Epidemic Collides with an Ancient Scourge: COVID-19 Associated with Tuberculosis.

Am J Respir Crit Care Med 2020 Jul 1. Epub 2020 Jul 1.

Columbia University Irving Medical Center, 21611, Medicine and Epidemiology, New York, New York, United States;

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http://dx.doi.org/10.1164/rccm.202003-0828IMDOI Listing

Pulmonary Aspergillosis in Patients with Suspected Ventilator-associated Pneumonia in UK Intensive Care Units.

Am J Respir Crit Care Med 2020 Jul 1. Epub 2020 Jul 1.

Queen's University Belfast, 1596, Belfast, United Kingdom of Great Britain and Northern Ireland;

Rationale: Aspergillus infection in patients with suspected ventilator-associated pneumonia remains uncharacterised due to absence of a disease definition and limited access to sensitive diagnostic tests.

Objectives: To estimate the prevalence and outcomes of Aspergillus infection in adults with suspected ventilator associated pneumonia.

Methods: Two prospective UK studies recruited 360 critically ill adults with new or worsening alveolar shadowing on chest X-ray and clinical/haematological parameters supporting suspected ventilator-associated pneumonia. Read More

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http://dx.doi.org/10.1164/rccm.202002-0355OCDOI Listing

Radiology-pathology Correlation in Recovered COVID-19, Demonstrating Organizing Pneumonia.

Am J Respir Crit Care Med 2020 Jul 1. Epub 2020 Jul 1.

Stanford University School of Medicine, Radiology, Stanford, California, United States;

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http://dx.doi.org/10.1164/rccm.202004-1278IMDOI Listing

Exercise Challenge to Test for Exercise-induced Bronchoconstriction.

Am J Respir Crit Care Med 2020 Jul;202(1):P1-P2

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http://dx.doi.org/10.1164/rccm.2021P1DOI Listing

Renin and Survival in Patients Given Angiotensin II for Catecholamine-Resistant Vasodilatory Shock.

Am J Respir Crit Care Med 2020 Jul 1. Epub 2020 Jul 1.

King's College London, Guy's & St Thomas Hospital, Critical Care, London, United Kingdom of Great Britain and Northern Ireland.

Rationale: Exogenous angiotensin II increases mean arterial pressure in patients with catecholamine-resistant vasodilatory shock (CRVS). We hypothesized that renin levels may identify patients most likely to benefit from such therapy.

Objectives: To test the kinetic changes in renin levels and their prognostic value in CRVS patients. Read More

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http://dx.doi.org/10.1164/rccm.201911-2172OCDOI Listing

COVID-19 Severity Correlates with Weaker T Cell Immunity, Hypercytokinemia and Lung Epithelium Injury.

Am J Respir Crit Care Med 2020 Jul 1. Epub 2020 Jul 1.

State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;

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http://dx.doi.org/10.1164/rccm.202005-1701LEDOI Listing

Single Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis.

Am J Respir Crit Care Med 2020 Jun 30. Epub 2020 Jun 30.

Yale University School of Medicine, 12228, Pulmonary, Critical Care, and Sleep Medicine, New Haven, Connecticut, United States;

Rationale: Cystic fibrosis (CF) is a life-shortening multisystem hereditary disease caused by abnormal chloride transport. CF lung disease is driven by innate immune dysfunction and exaggerated inflammatory responses that contribute to tissue injury. In order to define the transcriptional profile of this airway immune dysfunction, we performed the first single-cell transcriptome characterization of CF sputum. Read More

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http://dx.doi.org/10.1164/rccm.202004-0991OCDOI Listing

Single Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.

Am J Respir Crit Care Med 2020 Jun 30. Epub 2020 Jun 30.

Cincinnati Children's Hospital Medical Center, 2518, Cincinnati, Ohio, United States;

Rationale: Lymphangioleiomyomatosis (LAM) is a metastatic neoplasm of reproductive age women associated with mutations in tuberous sclerosis complex (TSC) genes. LAM causes cystic remodeling of the lung and progressive respiratory failure. The sources and cellular characteristics of LAM cells underlying disease pathogenesis remain elusive. Read More

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http://dx.doi.org/10.1164/rccm.201912-2445OCDOI Listing
June 2020
12.996 Impact Factor

SARS-CoV-2 Transmission and the Risk of Aerosol Generating Procedures.

Am J Respir Crit Care Med 2020 Jun 30. Epub 2020 Jun 30.

University of California San Diego, 8784, La Jolla, California, United States.

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http://dx.doi.org/10.1164/rccm.2020C11DOI Listing

The ABCs of Granulomatous Lung Diseases: Age-associated B Cells.

Am J Respir Crit Care Med 2020 Jun 30. Epub 2020 Jun 30.

University of Michigan Health System, 21614, Internal Medicine, Ann Arbor, Michigan, United States.

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http://dx.doi.org/10.1164/rccm.202006-2261EDDOI Listing

Transforming Diagnostics in Lung Transplantation: From Bronchoscopy to an A.I.-driven Approach.

Am J Respir Crit Care Med 2020 Jun 30. Epub 2020 Jun 30.

Temple University, 6558, Cardiovascular Surgery, Philadelphia, Pennsylvania, United States;

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http://dx.doi.org/10.1164/rccm.202005-1821EDDOI Listing

Chronic Hypersensitivity Pneumonitis, an Interstitial Lung Disease with Distinct Molecular Signatures.

Am J Respir Crit Care Med 2020 Jun 30. Epub 2020 Jun 30.

University of Colorado, School of Medicine, Department of Medicine, Aurora, Colorado, United States;

Rationale: Chronic hypersensitivity pneumonitis (CHP) is caused by an immune response to antigen inhalation and is characterized by variable histopathological and clinical features. A subset of CHP patients have usual interstitial pneumonia and appear to be clinically similar to patients with idiopathic pulmonary fibrosis (IPF).

Objectives: To determine the common and unique molecular features of CHP and IPF. Read More

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http://dx.doi.org/10.1164/rccm.202001-0134OCDOI Listing

Bedside Evaluation of Pulmonary Embolism by Saline Contrast Electrical Impedance Tomography Method:A Prospective Observational Study.

Am J Respir Crit Care Med 2020 Jun 25. Epub 2020 Jun 25.

Furtwangen University, Institute of Technical Medicine, Villingen-Schwenningen, Germany.

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http://dx.doi.org/10.1164/rccm.202005-1780LEDOI Listing

Serial Measurement of Cell-cycle Arrest Biomarkers [TIMP-2]•[IGFBP7] and Risk for Progression to Death, Dialysis or Severe Acute Kidney Injury in Patients with Septic Shock.

Am J Respir Crit Care Med 2020 Jun 25. Epub 2020 Jun 25.

University of Pittsburgh, Center for Critical Care Nephrology; Department of Critical Care Medicine, Pittsburgh, Pennsylvania, United States;

Rationale: Urinary tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) can predict AKI in patients with sepsis.

Objectives: Since most sepsis patients present with AKI, critical questions are whether biomarkers can inform on the response to treatment and whether they might be used to guide therapy.

Methods: We measured [TIMP-2]•[IGFBP7] before and after a 6-hour resuscitation in 688 patients with septic shock enrolled in the ProCESS trial. Read More

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http://dx.doi.org/10.1164/rccm.201906-1197OCDOI Listing

Characterization of the Inflammatory Response to Severe COVID-19 Illness.

Am J Respir Crit Care Med 2020 Jun 25. Epub 2020 Jun 25.

RCSI, Dublin, Ireland.

Rationale: Coronavirus disease 2019 (COVID-19) is a global threat to health. Its inflammatory characteristics are incompletely understood.

Objectives: To define the cytokine profile of COVID-19, and to identify evidence of immunometabolic alterations in those with severe illness. Read More

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http://dx.doi.org/10.1164/rccm.202005-1583OCDOI Listing

Role of TL1A/DR3 Axis in the Activation of ILC2s in Eosinophilic Asthmatics.

Am J Respir Crit Care Med 2020 Jun 25. Epub 2020 Jun 25.

McMaster University, 3710, Medicine, Hamilton, Ontario, Canada;

Rationale: Group 2 innate lymphoid cells (ILC2s) are critical for type 2 inflammation. In murine models of asthma, some ILC2s remain activated in the absence of epithelial-derived cytokine signaling, implicating alternate stimulatory pathways. Death receptor 3 (DR3), a member of the tumor necrosis factor receptor superfamily is expressed on ILC2s and genome wide association studies report an association between DR3 ligand, TNF like protein 1A (TL1A), and chronic inflammatory conditions. Read More

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http://dx.doi.org/10.1164/rccm.201909-1722OCDOI Listing

International Consensus on ANCA Testing in Eosinophilic Granulomatosis with Polyangiitis.

Am J Respir Crit Care Med 2020 Jun 25. Epub 2020 Jun 25.

University of Alberta, Medicine, Edmonton, Alberta, Canada.

An international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in eosinophilic granulomatosis with polyangiitis (EGPA) is presented. ANCA, specific for myeloperoxidase (MPO), can be detected in 30-35% of EGPA patients. MPO-ANCA should be tested with antigen-specific immunoassays in any patient with eosinophilic asthma and clinical features suggesting EGPA, including constitutional symptoms, purpura, polyneuropathy, unexplained heart, gastrointestinal or kidney disease, and/or pulmonary infiltrates or hemorrhage. Read More

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http://dx.doi.org/10.1164/rccm.202005-1628SODOI Listing

The Effect of ICS Withdrawal and Baseline Inhaled Treatment on Exacerbations in the IMPACT Study: A Randomized, Double-blind Multicenter Trial.

Am J Respir Crit Care Med 2020 Jun 25. Epub 2020 Jun 25.

NewYork-Presbyterian Hospital/Weill Cornell Medical Center, 159947, New York, New York, United States.

Rationale: In the IMPACT trial fluticasone furoate/umeclidinium/ vilanterol (FF/UMEC/VI) significantly reduced exacerbations compared with FF/VI or UMEC/VI in patients with symptomatic chronic obstructive pulmonary disease and a history of exacerbations.

Objectives: Understand whether inhaled corticosteroid (ICS) withdrawal affected IMPACT results given direct transition from prior maintenance medication to study medication at randomization.

Methods: Exacerbations and change from baseline in trough forced expiratory volume in 1 second (FEV) and St George's Respiratory Questionnaire (SGRQ) were analyzed by prior ICS use. Read More

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http://dx.doi.org/10.1164/rccm.201912-2478OCDOI Listing