342,142 results match your criteria American journal of reproductive immunology New York N.Y. : 1989[Journal]


Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011875. Epub 2019 Apr 19.

Ophthalmology, Singapore National Eye Centre, Singapore, Singapore.

Background: Glaucoma affects more than 70 million people worldwide, with about 10% being bilaterally blind, making it the leading cause of irreversible blindness globally. In patients with advanced glaucoma or those who have failed medical treatment without achieving adequate intraocular pressure (IOP) control, trabeculectomy (glaucoma filtration surgery where an ostium is created into the anterior chamber from underneath a partial thickness scleral flap to allow for aqueous flow out of the anterior chamber intointo the subconjunctival space forming a filtering bleb) and aqueous shunt surgery for more complex and refractory cases remain the mainstay therapies. Proliferation of fibrous tissue around an implanted aqueous shunt may block the diffusion of aqueous humour. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/14651858.CD011875.pub2
Publisher Site
http://dx.doi.org/10.1002/14651858.CD011875.pub2DOI Listing
April 2019
1 Read

Methylation Tolerance-based Functional Assay to Assess Variants of Unknown Significance in the MLH1 and MSH2 Genes and Identify Patients With Lynch Syndrome.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, F-75012 Paris, France; SIRIC CURAMUS, Equipe labellisée par la Ligue Nationale contre le Cancer. Electronic address:

Background & Aims: Approximately 75% of patients with suspected Lynch syndrome carry variants in MLH1 or MSH2-proteins encoded by these genes are required for DNA mismatch repair (MMR). However, 30% of these are variants of unknown significance (VUS). A assay that measures cell response to the cytotoxic effects of a methylating agent can determine the effects of VUS in MMR genes and identify patients with constitutional mismatch repair-deficiency syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2019.03.071DOI Listing

HIV co-infection in HTLV-1 carriers in Spain.

Virus Res 2019 Apr 15. Epub 2019 Apr 15.

UNIR Health Sciences School & Medical Center, Madrid, Spain. Electronic address:

Background: Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. In contrast, HTLV-1 is not endemic in Spain, despite hosting huge numbers of migrants from highly endemic regions. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01681702193017
Publisher Site
http://dx.doi.org/10.1016/j.virusres.2019.04.004DOI Listing
April 2019
2 Reads

Hearing Aid Prevalence and Factors Related to Use Among Older Adults From the Hispanic Community Health Study/Study of Latinos.

JAMA Otolaryngol Head Neck Surg 2019 Apr 18. Epub 2019 Apr 18.

National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.

Importance: Hearing loss is highly prevalent in the rapidly growing and aging Hispanic/Latino population in the United States. However, little is known or understood about hearing aid use among US adults from Hispanic/Latino backgrounds.

Objective: To describe hearing aid prevalence and factors associated with hearing aid use among US adults of Hispanic/Latino backgrounds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaoto.2019.0433DOI Listing

Distinct phenotype and function of circulating Vδ1+ and Vδ2+ γδT-cells in acute and chronic hepatitis B.

PLoS Pathog 2019 Apr 18;15(4):e1007715. Epub 2019 Apr 18.

Department of Internal Medicine, University of Michigan, Ann Arbor MI, United States of America.

Hepatitis B virus (HBV) persists with global and virus-specific T-cell dysfunction, without T-cell based correlates of outcomes. To determine if γδT-cells are altered in HBV infection relative to clinical status, we examined the frequency, phenotype and function of peripheral blood Vδ1+ and Vδ2+γδT-cells by multi-parameter cytometry in a clinically diverse North American cohort of chronic hepatitis B (CHB), acute hepatitis B (AHB) and uninfected control subjects. We show that circulating γδT-cells were comprised predominantly of CD3hiCD4- Vδ2+γδT-cells with frequencies that were 2-3 fold higher among Asian than non-Asian Americans and inversely correlated with age, but without differences between CHB, AHB and control subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007715DOI Listing
April 2019
1 Read

Detection of anti-Trypanosoma cruzi antibodies by chimeric antigens in chronic Chagas disease-individuals from endemic South American countries.

PLoS One 2019 18;14(4):e0215623. Epub 2019 Apr 18.

Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.

Background: Laboratory diagnosis of chronic Chagas disease is a troubling factor due to lack of reference tests. The WHO suggests the use of two distinct commercial serological tests in parallel. The performance of commercial immunoassays might fluctuate depending on the antigenic matrices and the local strains of T. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215623PLOS

Racial/ethnic differences in experimental pain sensitivity and associated factors - Cardiovascular responsiveness and psychological status.

PLoS One 2019 18;14(4):e0215534. Epub 2019 Apr 18.

Department of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, Maryland, United States of America.

This study evaluated the contributions of psychological status and cardiovascular responsiveness to racial/ethnic differences in experimental pain sensitivity. The baseline measures of 3,159 healthy individuals-non-Hispanic white (NHW): 1,637, African-American (AA): 1,012, Asian: 299, and Hispanic: 211-from the OPPERA prospective cohort study were used. Cardiovascular responsiveness measures and psychological status were included in structural equation modeling based mediation analyses. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215534PLOS

Barriers and facilitators of communication about off periods in Parkinson's disease: Qualitative analysis of patient, carepartner, and physician Interviews.

PLoS One 2019 18;14(4):e0215384. Epub 2019 Apr 18.

Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Research, Toronto Western Hospital, Toronto, Ontario, Canada.

Background: Successful patient-physician communication is critical for improving health outcomes, but research regarding optimal communication practices in Parkinson's disease is limited. The objective of the current study was to investigate barriers and facilitators of communication between persons with Parkinson's disease, carepartners, and physicians, specifically in the setting of off periods, with the goal of identifying ways to improve patient-carepartner-physician communication.

Method: We interviewed persons with Parkinson's, carepartners, and physicians (specialists and non-specialists) using a semi-structured questionnaire to identify and describe experiences, barriers, and facilitators relating to communication about off periods in Parkinson's disease. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215384PLOS
April 2019
1 Read

A Feasibility Study to Attribute Patients to Primary Interns on Inpatient Ward Teams Using Electronic Health Record Data.

Acad Med 2019 Apr 16. Epub 2019 Apr 16.

D.J. Schumacher is associate professor of pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio. D.T.Y. Wu is assistant professor of biomedical informatics and pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio. K. Meganathan is senior clinical data analyst, Center for Health Informatics, University of Cincinnati College of Medicine, Cincinnati, Ohio. L. Li is research associate, Center for Health Informatics, University of Cincinnati College of Medicine, Cincinnati, Ohio. B. Kinnear is assistant professor of pediatrics and internal medicine, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio. D.R. Sall is assistant professor of internal medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio. E. Holmboe is senior vice president for milestones development and evaluation, Accreditation Council for Graduate Medical Education, Chicago, Illinois. C. Carraccio is vice president of competency-based assessment, American Board of Pediatrics, Chapel Hill, North Carolina. C. van der Vleuten is professor of education, Department of Educational Development and Research, Faculty of Health, Medicine, and Life Sciences; and scientific director, School of Health Professions Education (SHE), Maastricht University, Maastricht, The Netherlands. J. Busari is consultant pediatrician and associate professor of medical education, Maastricht University, Maastricht, The Netherlands. M. Kelleher is assistant professor of pediatrics and internal medicine, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio. D. Schauer is associate professor of internal medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio. E. Warm is professor of medicine and internal medicine program director, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Purpose: To inform graduate medical education (GME) outcomes at the individual resident level, this study sought a method for attributing care for individual patients to individual interns based on "footprints" in the electronic health record (EHR).

Method: Primary interns caring for patients on an internal medicine inpatient service were recorded daily by five attending physicians of record at University of Cincinnati Medical Center in August 2017 and January 2018. These records were considered gold standard identification of primary interns. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00001888-900000000-9761
Publisher Site
http://dx.doi.org/10.1097/ACM.0000000000002748DOI Listing
April 2019
1 Read

American Urogynecologic Society Systematic Review: Microscopic Hematuria as a Screening Tool for Urologic Malignancies in Women.

Female Pelvic Med Reconstr Surg 2019 Apr 12. Epub 2019 Apr 12.

Vanderbilt University Medical Center, Nashville, TN.

Introduction: Most causes of microscopic hematuria (MH) are benign but may indicate an underlying malignancy. Current MH evaluation guidelines are reflective of male urologic malignancy risks. The objective of this systematic review was to evaluate whether the finding of MH predicts subsequent urologic malignancy in women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SPV.0000000000000726DOI Listing

Automated Ambulatory Blood Pressure Measurements and Intraoperative Hypotension in Patients Having Noncardiac Surgery with General Anesthesia: A Prospective Observational Study.

Anesthesiology 2019 Apr 15. Epub 2019 Apr 15.

From the Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine (B.S., P.C.R., C.B., J.Y.N., S.S.) the Department of Medical Biometry and Epidemiology (H.O.P.) University Medical Center Hamburg-Eppendorf, Hamburg, Germany the Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio (D.I.S.) the Department of Anesthesiology and Intensive Care Medicine, University Medical Center Rostock, Rostock, Germany (D.A.R.).

What We Already Know About This Topic: Intraoperative hypotension is associated with significant postoperative complicationsIntraoperative hypotension has been defined relative to preinduction blood pressureBlood pressure varies during the day, and the relationship between preinduction blood pressure and usual blood pressure over 24 h is incompletely describedSimilarly the relationship between low blood pressure intraoperatively and 24-h usual blood pressure is unknown WHAT THIS ARTICLE TELLS US THAT IS NEW: There is a poor correlation between preinduction blood pressure and the usual blood pressure over 24 hIn two thirds of patients, the lowest postinduction and intraoperative pressures were lower than the lowest nighttime blood pressure BACKGROUND:: Normal blood pressure varies among individuals and over the circadian cycle. Preinduction blood pressure may not be representative of a patient's normal blood pressure profile and cannot give an indication of a patient's usual range of blood pressures. This study therefore aimed to determine the relationship between ambulatory mean arterial pressure and preinduction, postinduction, and intraoperative mean arterial pressures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ALN.0000000000002703DOI Listing

Study of Knowledge, Attitudes, and Practices Toward Risk Factors and Early Detection of Noncommunicable Diseases Among Rural Women in India.

J Glob Oncol 2019 Apr;5:1-10

3 International Agency for Research on Cancer, Lyon, France.

Purpose: In recognition of the growing burden of noncommunicable diseases (NCDs), including cancer, we assessed the knowledge, attitudes, and practices of rural women in low-resourced countries toward common NCDs and the barriers they face in receiving NCD early detection services.

Patients And Methods: The study was conducted in a rural block of India using the Rapid Assessment and Response Evaluation ethnographic assessment, which included in-depth interviews of key health officials; focus group discussions with women, men, teachers, and health workers from the block; and a knowledge, attitudes, and practices questionnaire survey. The home-based survey was conducted among 1,192 women selected from 50 villages of the block using a two-stage randomization process and stratified to 30- to 44-year and 45- to 60-year age-groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JGO.18.00181DOI Listing

The Eighteen of 1918-1919: Black Nurses and the Great Flu Pandemic in the United States.

Am J Public Health 2019 Apr 18:e1-e8. Epub 2019 Apr 18.

At the time of the study, Marian Moser Jones and Matilda Saines were with the University of Maryland School of Public Health, College Park.

This article examines the role of Black American nurses during the 1918-1919 influenza pandemic and the aftermath of World War I. The pandemic caused at least 50 million deaths worldwide and 675 000 in the United States. It occurred during a period of pervasive segregation and racial violence, in which Black Americans were routinely denied access to health, educational, and political institutions. Read More

View Article

Download full-text PDF

Source
https://ajph.aphapublications.org/doi/10.2105/AJPH.2019.3050
Publisher Site
http://dx.doi.org/10.2105/AJPH.2019.305003DOI Listing
April 2019
1 Read

Does Arthroscopic Suture-Spanning Augmentation of Single-Row Repair Reduce the Retear Rate of Massive Rotator Cuff Tear?

Am J Sports Med 2019 Apr 18:363546519836419. Epub 2019 Apr 18.

Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: Several surgical techniques have been proposed for massive rotator cuff tears (MRCTs), but the failure rates remain high. The suture-spanning augmentation technique of single-row (SSA-SR) repair was shown to reduce failure rates in cadaveric studies, but the outcome in vivo remains unclear.

Purpose: To determine if adding spanning sutures to SR repair during MRCT repairs can improve functional outcome and reduce failure rates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0363546519836419DOI Listing

Changing the Question.

Authors:
Daniel Brudney

Hastings Cent Rep 2019 Mar;49(2):9-16

Jack, who is seventy-five years old, is in the hospital with a terminal condition that has undermined his cognitive faculties. He has left no advance directive and has never had a conversation in which he made his treatment wishes remotely clear. Yet now, a treatment decision must be made, and in modern American medicine, the treatment decision for Jack is supposed to be made by a surrogate decision-maker, who is supposed to use a decision-making standard known as "substituted judgment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hast.988DOI Listing

Joint EFLM-COLABIOCLI recommendation for venous blood sampling.

Ann Biol Clin (Paris) 2019 Apr;77(2):131-154

This document provides a joint recommendation for venous blood sampling of the European federation of clinical chemistry and laboratory medicine (EFLM) Working Group for preanalytical phase (WG-PRE) and Latin American working group for preanalytical phase (WG-PRE-LATAM) of the Latin America confederation of clinical biochemistry (COLABIOCLI). It offers guidance on the requirements for ensuring that blood collection is a safe and patient-centered procedure and provides practical guidance on how to successfully overcome potential barriers and obstacles to its widespread implementation. The target audience for this recommendation are healthcare staff members directly involved in blood collection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/abc.2019.1419DOI Listing
April 2019
1 Read

Expanding Environmental Health Literacy-A Focus on Water Quality and Tribal Lands.

J Health Commun 2019 Apr 18:1-8. Epub 2019 Apr 18.

c Department of Social and Behavioral Science , Harvard T.H. Chan School of Public Health , Boston , MA , USA.

Environmental health literacy (EHL), an evolving concept, has potential for significant public health impact. However, complex skills are needed to access and use information, to study and document hazards, to link findings to health outcomes, and to understand the complexities of regulations and laws needed to take efficacious action. Because water issues are creating headlines world-wide, we draw from several water-related cases on American Indian tribal lands to examine some of the complexities associated with building needed skills, obtaining accessible information, and navigating the layers of laws and regulations that enable or inhibit efficacious action. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10810730.2019.1
Publisher Site
http://dx.doi.org/10.1080/10810730.2019.1597948DOI Listing
April 2019
1 Read

A qualitative investigation of beliefs about work-related crises in the United States.

J Couns Psychol 2019 Apr 18. Epub 2019 Apr 18.

Department of Guidance and Psychological Counseling.

Globalization, technological advancements, and macroeconomic forces have created significant challenges for working in the United States and other countries. Recent crises about working include long-term unemployment/underemployment and the rise of precarious work, which negatively impact individuals' mental health and well-being. To fully understand the nature and impact of these problems, it is essential to give voice to the people whose lives are affected by the work-related crises. Read More

View Article

Download full-text PDF

Source
http://doi.apa.org/getdoi.cfm?doi=10.1037/cou0000343
Publisher Site
http://dx.doi.org/10.1037/cou0000343DOI Listing
April 2019
1 Read

The System for Coding Interactions and Family Functioning (SCIFF) in low-income and urban adolescents.

Psychol Assess 2019 Apr 18. Epub 2019 Apr 18.

Department of Psychology.

Reliable, brief, and cost-effective methods to assess parenting are critical for advancing etiological research and translational efforts within parenting science. In the current study, we adapted the System for Coding Interactions and Family Functioning (SCIFF) for use among a sample of mostly racial minority adolescents aged 15 years old, growing up in a low-income urban setting. A multiethnic team coded videotapes of a family interaction task designed to elicit conflict. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1037/pas0000719DOI Listing

Psoas and Paraspinous Muscle Measurements on Computed Tomography Predict Mortality in European Americans with Type 2 Diabetes Mellitus.

J Frailty Aging 2019 ;8(2):72-78

Barry I. Freedman, MD, Internal Medicine - Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1053, Phone: 336-716-6461, Fax: 336-716-4318,

Background: Appendicular skeletal muscle mass index and muscle attenuation (density) are negatively associated with mortality in European-derived populations.

Objectives: The present analyses assessed association between axial skeletal muscle density and muscle index with mortality in European Americans with type 2 diabetes mellitus (T2D).

Design: Single-center observational study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14283/jfa.2019.5DOI Listing
January 2019

High resolution melting analysis as an accurate method for identifying in canine serum samples.

J Vector Borne Dis 2018 Oct-Dec;55(4):315-320

Department of Medical Parasitology and Mycology, School of Public Health, Tehran, Iran.

Background & Objectives: Leishmania (L.) infantum is the principal agent of visceral leishmaniasis (VL) in the Mediterranean and American regions. So far different molecular methods including high resolution melting (HRM) analysis have been developed for detecting and identifying L. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0972-9062.256568DOI Listing
April 2019
1 Read

Approaches for the successful isolation and cell culture of American species.

J Vector Borne Dis 2018 Oct-Dec;55(4):258-264

Emerging and Re-emerging Diseases Laboratory, CIR Hideyo Noguchi, Universidad Autónoma de Yucatán (UADY), Mérida, México.

Rickettsia are intracellular vector-borne bacteria, which are the etiologic agent of severe infections that could inflict death to their host. The intracellular behaviour of Rickettsia makes the study of its genetics, proteomics and cellular processes very difficult. Hence, isolation remains an important experimental technique that permits the obtention of important yields of bacteria, useful for a broad range of experiments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0972-9062.256560DOI Listing
April 2019
1 Read

Perspectives on gender parity in STEM/Bioanalysis: an interview with Binodh DeSilva.

Authors:
Binodh De Silva

Bioanalysis 2019 Apr 18. Epub 2019 Apr 18.

Head, Analytical Strategy & Operations, Bristol-Myers Squibb, New Brunswick, NJ 08903, USA.

Biography Binodh DeSilva, PhD Vice President Analytical Strategy & Operations at Bristol-Myer Squibb (BMS) Company in New Brunswick, NJ, USA. She is responsible for leading the regulated analytical (small and large molecule), microbiology and industrial hygiene laboratories as well as the Chemistry, Manufacturing & Controls (CMC) regulatory document management functions in Product Development. She received her Bachelor's in Analytical Chemistry from the University of Colombo, Sri Lanka in 1987, and a PhD in Chemistry (Bioanalytical) in 1994 from the University of Kansas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/bio-2019-0068DOI Listing

RW-2018-Research Workshop: The Effect of Nutrition on Epigenetic Status, Growth, and Health.

JPEN J Parenter Enteral Nutr 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, Division of Pediatric Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

The goal of the 2018 American Society for Parenteral and Enteral Nutrition (ASPEN) Research Workshop was to explore the influence of nutrition and dietary exposure to xenobiotics on the epigenome during critical periods in development and how these exposures influence both disease incidence and severity transgenerationally. A growing compendium of research indicates that the incidence and severity of common and costly human diseases may be influenced by dietary exposures and deficiencies that modify the epigenome. The greatest periods of vulnerability to these exposures are the periconception period and early childhood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jpen.1536DOI Listing

Expanding Phaseolus coccineus Genomic Resources: De Novo Transcriptome Assembly and Analysis of Landraces 'Gigantes' and 'Elephantes' Reveals Rich Functional Variation.

Biochem Genet 2019 Apr 17. Epub 2019 Apr 17.

Institute of Applied Biosciences, CERTH, Thermi, 570 01, Thessaloniki, Greece.

Beans are one of the most important staple crops in the world. Runner bean (Phaseolus coccineus L.) is a small-scale agriculture crop compared to common bean (Phaseolusvulgaris). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10528-019-09920-6DOI Listing
April 2019
2 Reads

Comparative Effects of Medical Versus Surgical Weight Loss on Body Composition: a Pilot Randomized Trial.

Obes Surg 2019 Apr 17. Epub 2019 Apr 17.

Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objective: Bariatric surgery leads to more rapid and greater weight loss (WL) compared to medical weight loss (MWL), but the differences in body composition (BC) changes for these modalities remain unclear. Due to the known health risks associated with central adiposity, we compared the changes in regional distribution of fat mass (FM) and lean mass (LM) after surgical versus MWL.

Methods: In this 1:1:1 randomized trial among 15 persons with type 2 diabetes and body mass index (BMI) 30-39. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11695-019-03879-4DOI Listing

Changes in the 8th Edition of the American Joint Committee on Cancer (AJCC) Staging of Head and Neck Cancer: Rationale and Implications.

Curr Oncol Rep 2019 Apr 17;21(6):52. Epub 2019 Apr 17.

Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

Purpose Of Review: The objectives of this article are to review the major changes in the staging of head and neck cancers and the rationale for the modifications.

Recent Findings: Information gathered from various institutional reports lead to a better understanding of the clinical and biological behavior of head and neck tumors, resulting in distinct outcomes, which were used to update the staging system. This article reviews the changes in the staging of head and neck cancers published in the 8th edition of the AJCC/UICC TNM staging system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11912-019-0799-xDOI Listing

Heat transfer enhancement in the boundary layer flow of hybrid nanofluids due to variable viscosity and natural convection.

Heliyon 2019 Apr 4;5(4):e01469. Epub 2019 Apr 4.

Department of Studies and Research in Mathematics, Kuvempu University, Shankaraghatta, 577 451, Shimoga, Karnataka, India.

The aim of the current work is to explore how heat transfer can be enhanced by variations in the basic properties of fluids in the presence of free convection with the aid of suspended hybrid nanofluids. Also, the influence of the Laurentz force on the flow is considered. The mathematical equations are converted into a pair of self-similarity equations by applying appropriate transformations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.heliyon.2019.e01469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451174PMC

Care of acute conditions and chronic diseases in Canada and the United States: Rapid systematic review and meta-analysis.

J Public Health Res 2019 Mar 11;8(1):1479. Epub 2019 Mar 11.

School of Social Work.

This study tested the hypothesis that socioeconomically vulnerable Canadians with diverse acute conditions or chronic diseases have health care access and survival advantages over their counterparts in the USA. A rapid systematic review retrieved 25 studies (34 independent cohorts) published between 2003 and 2018. They were synthesized with a streamlined meta-analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4081/jphr.2019.1479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444377PMC

Clinical Conundrums in the Management of Diabetic Ketoacidosis in the Elderly.

J Transl Int Med 2019 Mar 29;7(1):10-14. Epub 2019 Mar 29.

St. Vincent Hospital Indianapolis, IN, Indianapolis, USA.

One of the dreaded life-threatening complications of diabetes mellitus (DM) is diabetic ketoacidosis (DKA). American Diabetic Association (ADA) came out with 2018 guidelines on the management of DM and its complications, but these are woefully silent on the clinical conundrums that accompany DKA in elderly patients. In elderly patients, DKA is often complicated by sepsis, atrial fibrillation, polypharmacy, nonketotic hyperosmolar states, atypical clinical presentations, acute kidney injury (AKI), dementia, and noncompliance with medications. Read More

View Article

Download full-text PDF

Source
http://content.sciendo.com/view/journals/jtim/7/1/article-p1
Publisher Site
http://dx.doi.org/10.2478/jtim-2019-0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463825PMC
March 2019
1 Read

INJURY INCIDENCE IN COMPETITIVE CROSS-COUNTRY SKIERS: A PROSPECTIVE COHORT STUDY.

Int J Sports Phys Ther 2019 Apr;14(2):237-252

Professor Emerita, Department of Rehabilitation Sciences, University of Vermont, Burlington, VT, USA.

Background/purpose: Endurance sports, including cross-country skiing, require long hours of repetitive training potentially increasing the chance of injury, yet injury incidence and risk factors for adult cross-country skiers remain relatively unexplored. Data for elite adult north American competitive cross-country skiers is unexplored. A 12 month prospective surveillance study was undertaken to calculate the injury incidence and exposure of cross-country skiers. Read More

View Article

Download full-text PDF

Source

Fundamental motor skills, screen-time, and physical activity in preschoolers.

J Sport Health Sci 2019 Mar 24;8(2):114-121. Epub 2018 Nov 24.

Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.

Purpose: To examine the associations among preschoolers fundamental motor skills, screen-time, physical activity (PA), and sedentary behavior (SB).

Methods: Children ages 3-4years were enrolled in a prospective observational trial of PA. Trained assessors conducted the Test of Gross Motor Development-3rdedition (TGMD-3), and the Movement Assessment Battery for Children-2nd edition, and parent-reported child screen-time and sociodemographic information. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S20952546183010
Publisher Site
http://dx.doi.org/10.1016/j.jshs.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450921PMC
March 2019
1 Read

A reply to "" by Burjek

J Thorac Dis 2019 Mar;11(Suppl 3):S476-S477

Department of Emergency Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/jtd.2019.02.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424786PMC

Prioritizing mutational profiling for targeted therapy of lung adenocarcinoma.

J Thorac Dis 2019 Mar;11(Suppl 3):S216-S219

Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/jtd.2019.02.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424773PMC

How is implementation research applied to advance health in low-income and middle-income countries?

BMJ Glob Health 2019 7;4(2):e001257. Epub 2019 Mar 7.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

This paper examines the characteristics of implementation research (IR) efforts in low-income and middle-income countries (LMICs) by describing how key IR principles and concepts have been used in published health research in LMICs between 1998 and 2016, with focus on how to better apply these principles and concepts to support large-scale impact of health interventions in LMICs. There is a stark discrepancy between principles of IR and what has been published. Most IR studies have been conducted under conditions where the researchers have considerable influence over implementation and with extra resources, rather than in 'real world' conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjgh-2018-001257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441291PMC

Randomised, double-blind, phase III study comparing the infliximab biosimilar, PF-06438179/GP1111, with reference infliximab: efficacy, safety and immunogenicity from week 30 to week 54.

RMD Open 2019 28;5(1):e000876. Epub 2019 Mar 28.

Metroplex Clinical Research Center, Dallas, Texas, USA.

Objective: To investigate the efficacy, safety and immunogenicity of PF-06438179/GP1111 (PF-SZ-IFX) compared with European reference infliximab (Remicade; ref-IFX) in patients with moderate-to-severe, active rheumatoid arthritis after continued long-term use of PF-SZ-IFX, and in patients who were switched from ref-IFX to PF-SZ-IFX.

Methods: REFLECTIONS B537-02 was a double-blind, active-controlled, multinational study in which patients (N=650) were initially randomised to PF-SZ-IFX or ref-IFX for 30 weeks (treatment period [TP] 1). During weeks 30-54 (TP2), the PF-SZ-IFX group (n=280) continued treatment with PF-SZ-IFX (PF-SZ-IFX/PF-SZ-IFX) and patients in the ref-IFX group (n=286) were rerandomised (1:1) to continue ref-IFX (ref-IFX/ref-IFX) (n=143) or switch to PF-SZ-IFX (ref-IFX/PF-SZ-IFX) (n=143) for a further 24 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/rmdopen-2018-000876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446180PMC

MRI of skeletal muscles in patients with idiopathic inflammatory myopathies: characteristic findings and diagnostic performance in dermatomyositis.

RMD Open 2019 28;5(1):e000850. Epub 2019 Mar 28.

Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Objective: To define the characteristic findings on MRI of skeletal muscles in patients with dermatomyositis (DM) relative to those in patients with other idiopathic inflammatory myopathies (IIMs) and to assess their diagnostic performance in DM.

Methods: Thirty-six patients with DM, 17 patients with amyopathic DM, 19 patients with polymyositis and 16 patients with non-IIM classified by the 2017 European League Against Rheumatism/American College of Rheumatology criteria were included in this study. The following MRI findings (short-tau inversion recovery [STIR] and gadolinium-enhanced fat-suppressed T1-weighted imaging [Gd-T1WI]) for proximal limb muscles were compared between the disease groups and between myositis-specific autoantibodies/myositis-associated autoantibodies (MSAs/MAAs)-positive and MSAs/MAAs-negative groups: structures with high signal intensity (HSI) (subcutaneous, fascia, muscle); distributions of HSI areas in muscle (diffuse, patchy, peripheral) and patterns of HSI in muscle (honeycomb, foggy, strong HSI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/rmdopen-2018-000850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443133PMC

Exercise-related sudden cardiac death of an American football player with arrhythmogenic right ventricular dysplasia/cardiomyopathy AND sarcoidosis.

Clin Case Rep 2019 Apr 19;7(4):686-688. Epub 2019 Feb 19.

Department of Electrophysiology, Heart Center University of Leipzig Leipzig Germany.

This case emphasizes the value of cardiac MRI and genetic testing in the early phase of ARVD/C. It also emphasizes the increased risk of SCD for patients with ARVD/C participating in competitive sports, even with immediate cardiopulmonary resuscitation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccr3.2071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452462PMC

Cross-cultural representations of dementia: an exploratory study.

J Glob Health 2019 Jun;9(1):011001

Department of Psychology, School of Social Sciences, Heriot Watt University, Edinburgh, UK.

Background: An ageing global population will bring a significant increase in the prevalence of dementia, with the need for a collaborative international effort to combat this public health challenge being increasingly recognised. To be successful, this cooperation must be sensitive to the different cultural environments in which dementia is positioned, which shape the variety of clinical, political and social approaches to the condition worldwide. The aim of this project is to examine the social representations of dementia among people from three countries with different health care systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7189/jogh.09.01101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445496PMC
June 2019
1 Read

Budget Impact of Omadacycline for the Treatment of Patients with Community-Acquired Bacterial Pneumonia in the United States from the Hospital Perspective.

Am Health Drug Benefits 2019 Feb;12(1-Supplement 1):S1-S12

Professor, Albany College of Pharmacy and Health Sciences, NY.

Background: Community-acquired bacterial pneumonia (CABP) is an acute, lower respiratory bacterial infection. Despite advances in medical care, CABP remains associated with considerable morbidity, mortality, and healthcare costs; early empiric treatment is recommended by the Infectious Diseases Society of America and by the American Thoracic Society. Omadacycline is an oral and intravenous (IV) once-daily aminomethylcycline antibiotic that is approved in the United States for the treatment of adult patients with CABP. Read More

View Article

Download full-text PDF

Source
February 2019
1 Read

Analysis of pre-residency research productivity, dual degree status, and gender distribution of underrepresented minorities among a current United States radiation oncology junior resident class.

Rep Pract Oncol Radiother 2019 May-Jun;24(3):284-287. Epub 2019 Apr 5.

Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN, United States.

Background: Among the most competitive medical subspecialties, representation of underrepresented minorities (African-American race and/or Hispanic ethnicity) among resident trainees has historically been low compared to their United States Census general population representation. Research productivity and dual degree status may impact residency applicant competitiveness. To date, such an analysis has yet to be performed in Radiation Oncology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rpor.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451161PMC

Seven novel variants expand the spectrum of related Leber congenital amaurosis in the Chinese population.

Mol Vis 2019 18;25:204-214. Epub 2019 Mar 18.

Department of Ophthalmology of Shanghai Tenth People's Hospital, and Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China.

Purpose: To screen in 187 families with Leber congenital amaurosis (LCA).

Methods: Sanger sequencing and/or targeted exome sequencing was employed to identify mutations in the gene, and intrafamilial cosegregation analysis if DNA was available. In silico analyses and splicing assay were used to evaluate the variants' pathogenicity. Read More

View Article

Download full-text PDF

Source

New pycnodontiform fishes (Actinopterygii, Neopterygii) from the Early Cretaceous of the Argentinian Patagonia.

Cretac Res 2019 Feb;94:45-58

University of Vienna, Department of Palaeontology, Geocenter, Althanstrasse 14, 1090, Vienna, Austria.

Here we describe new pycnodontiform fish material recovered from the marine Agrio Formation (lower Valanginian-lower Hauterivian) of the Neuquén Province in the south-western of Patagonia, Argentina. The new material include an incomplete skull and an incomplete prearticular dentition. The incomplete skull consists of some dermal and endochondral elements as well as dental remains and represents a new large-sized gyrodontid that is referred to a new species, . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cretres.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464094PMC
February 2019

[Comparison of effectiveness and complications between two different methods of augmentation cystoplasty].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):293-297

Department of Urology, Peking University People's Hospital, Beijing 100044, China.

Objective: To compare the effectiveness and complications between enterocystoplasty and small intestinal submucosa (SIS) cystoplasty through follow-ups of patients with augmentation cystoplasty in Peking University People's Hospital, offering alternative approach for future treatment.

Methods: In this study, retrospective analyses were carried out in 10 patients who underwent enterocystoplasty or SIS cystoplasty in Peking University People's Hospital from November 2011 to December 2016. Clinical data were collected including medical history, surgical procedures, laboratory examinations and complications. Read More

View Article

Download full-text PDF

Source

Electrocardiographic Criteria of Right Ventricular Hypertrophy in Patients with Chronic Thromboembolic Pulmonary Hypertension after Balloon Pulmonary Angioplasty.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Cardiovascular Medicine, Fukushima Medical University, Japan.

Background Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease that leads to right-sided heart failure with electrocardiographic abnormalities. There are only a few reports about the effects of balloon pulmonary angioplasty for CTEPH on the electrocardiographic criteria of right ventricular hypertrophy. Objective To determine the effect of balloon angioplasty on electrocardiography in patients with CTEPH. Read More

View Article

Download full-text PDF

Source
https://www.jstage.jst.go.jp/article/internalmedicine/advpub
Publisher Site
http://dx.doi.org/10.2169/internalmedicine.2320-18DOI Listing
April 2019
1 Read

Timing of Palliative Consultation for Children During a Fatal Illness.

Hosp Pediatr 2019 Apr 17. Epub 2019 Apr 17.

Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio;

Background: The American Academy of Pediatrics recommends palliative care for children at the diagnosis of serious illness. Yet few children who die receive specialty palliative care consultation, and when it is provided, palliative care consultation tends to occur after >75% of the time from diagnosis until death. Focusing on the timing of palliative consultation in relation to the date of diagnosis, we evaluated factors predicting earlier receipt of pediatric palliative care in a cohort of decedents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/hpeds.2018-0169DOI Listing

Multivariate genome-wide association study of rapid automatised naming and rapid alternating stimulus in Hispanic American and African-American youth.

J Med Genet 2019 Apr 17. Epub 2019 Apr 17.

Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA

Background: Rapid automatised naming (RAN) and rapid alternating stimulus (RAS) are reliable predictors of reading disability. The underlying biology of reading disability is poorly understood. However, the high correlation among RAN, RAS and reading could be attributable to shared genetic factors that contribute to common biological mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jmedgenet-2018-105874DOI Listing

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial.

Lancet 2019 Apr 12. Epub 2019 Apr 12.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes.

Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(19)30772-XDOI Listing

Exploring the emerging role of the microbiome in cancer immunotherapy.

J Immunother Cancer 2019 Apr 17;7(1):108. Epub 2019 Apr 17.

Department of Pathology, The University of Chicago, Chicago, IL, USA.

The activity of the commensal microbiota significantly impacts human health and has been linked to the development of many diseases, including cancer. Gnotobiotic animal models have shown that the microbiota has many effects on host physiology, including on the development and regulation of immune responses. More recently, evidence has indicated that the microbiota can more specifically influence the outcome of cancer immunotherapy. Read More

View Article

Download full-text PDF

Source
https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0
Publisher Site
http://dx.doi.org/10.1186/s40425-019-0574-4DOI Listing
April 2019
1 Read