25,757 results match your criteria American journal of ophthalmology[Journal]


Effect of Timolol on Aqueous Humor Outflow Facility in Healthy Human Eyes.

Am J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology, Mayo Clinic, Rochester, MN. Electronic address:

Purpose: Hyposecretion of aqueous humor has been postulated to adversely affect trabecular meshwork health and outflow resistance. However, the effect of medications that reduce aqueous humor production on outflow facility in living human eyes is unclear. In this study we evaluated the effect of timolol, an aqueous humor flow suppressant, on outflow facility in healthy eyes. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.014DOI Listing
February 2019

Risk factors associated with persistent anterior uveitis after cataract surgery.

Am J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado, USA. Electronic address:

Purpose: To identify risk factors for the development of persistent anterior uveitis (PAU) following uncomplicated phacoemulsification cataract extraction in patients without histories of uveitis or auto-immune diseases.

Design: Retrospective cohort study.

Methods: Medical records were reviewed of patients who underwent phacoemulsification cataract extraction with intraocular lens implantation between January 1, 2014, and December 31, 2016 at the University of Colorado Hospital. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.016DOI Listing
February 2019

Predictive Factors for the Rate of Visual Field Progression in the Advanced Imaging for Glaucoma Study.

Am J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Casey Eye Institute, Oregon Health & Science University. Electronic address:

Purpose: To investigate predictive factors associated with the rate of visual field (VF) loss in open-angle glaucoma.

Design: Prospective multicenter cohort study.

Methods: Perimetric glaucoma patients of the Advanced Imaging for Glaucoma study were selected for analysis if they had 9 completed visits. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.015DOI Listing
February 2019

In Vivo Confocal Microscopy Demonstrates Increased Immune Cell Densities in Corneal Graft Rejection Correlating with Signs and Symptoms.

Am J Ophthalmol 2019 Feb 18. Epub 2019 Feb 18.

Ocular Surface Imaging Center, Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA; Center for Translational Ocular Immunology, and Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA. Electronic address:

Purpose: Diagnosis of graft rejection is based on patient symptoms and on clinical signs by the slit-lamp biomicroscopy. The purpose of this study is to investigate whether laser in vivo confocal microscopy (IVCM) can aid in the diagnosis of corneal graft rejection by detecting cellular corneal changes that take place after transplantation.

Design: Prospective case-control study. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.013DOI Listing
February 2019

Prevalence and clinical patterns of ocular complications associated with anti-PD-1/PD-L1 anticancer immunotherapy.

Am J Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Assistance Publique Hôpitaux de Paris, Hôpital Bicêtre, Service d'Ophtalmologie, DHU Vision & Handicaps, Centre de référence pour les maladies rares en ophtalmologie (OPHTARA), F-94275, Le Kremlin-Bicêtre, France; Université Paris-Sud, F-94276, Le Kremlin-Bicêtre, France; INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, F-94276, Le Kremlin-Bicêtre, France; CEA, DSV/iMETI, IDMIT, F-92265, Fontenay-aux-Roses, France Department of Immunology of viral and auto-immune disease, (IMVA/ IDMIT), UMR1184, CEA, Fontenay-aux-Roses. Electronic address:

Purpose: Immune checkpoint inhibitors (ICI) targeting the programmed cell death protein 1 (PD-1), or its ligand PD-L1, are the mainstay of metastatic cancer treatment. Patients receiving these treatments may develop immune-related adverse events (irAEs). This study aimed to estimate the prevalence and describe the clinical patterns of moderate to severe ocular irAEs-associated with anti-PD-(L)1 treatment. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.012DOI Listing
February 2019

"Intraocular Oxygen and Antioxidant Status: New Insights on the Effect of Vitrectomy and Glaucoma Pathogenesis".

Am J Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Department of Ophthalmology and Visual Sciences Washington University School of Medicine, St. Louis, Missouri.

Purpose: To investigate correlations of oxygen (pO) in the ocular anterior segment of human eyes and aqueous humor antioxidant levels of ascorbate (AsA) and total reactive antioxidant potential (TRAP) with glaucoma and vitreous status.

Methods: This prospective, cross-sectional study stratified patients (n=288 eyes) by lens and vitreous status and presence of primary open angle glaucoma for statistical analyses. Intraocular pO measurements with a fiberoptic probe were made in patients at the beginning of planned glaucoma and/or cataract surgery. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.008DOI Listing
February 2019

Regenerative Surgery of the Corneal Stroma for Advanced Keratoconus: One Year Outcomes.

Am J Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Cell Engineering Laboratory, IdiPAZ, La Paz Hospital Research Institute, Madrid, Spain.

Purpose: To evaluate the one-year safety and efficacy of the cellular therapy of the corneal stroma by implanting autologous adipose derived adult stem cells (ADASc) with or without sheets of decellularized donor human corneal stroma within the stroma of patients with advanced keratoconus.

Methods: Prospective interventional non-randomized series of cases. Fourteen consecutive patients were selected and distributed into 3 experimental groups: A) Implantation of autologous ADASc alone (3x 10/1mL ) (n:5); B) Decellularized donor 120 μm thick corneal stroma lamina alone (n:5); C) Recellularized donor lamina with 1x10 autologous ADASc+ another 1x10/1mL cells at the time of the surgery (n:4). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.009DOI Listing
February 2019

THE SMALL FATAL CHOROIDAL MELANOMA STUDY A Survey by the European Ophthalmic Oncology Group.

Am J Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Ocular Oncology Service, Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Purpose: To determine the size at which choroidal melanomas can metastasize and to report the characteristics of small fatal choroidal melanomas (SFCM).

Design: Retrospective case series.

Methods: Ten ocular oncology services submitted 45 patients with a choroidal melanoma 3 mm or less in thickness and 9 mm or less in largest basal diameter (LBD), when treated, who developed metastases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193006
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http://dx.doi.org/10.1016/j.ajo.2019.01.031DOI Listing
February 2019
5 Reads

Visual and Clinical Outcome of Macular Edema Complicating Pediatric Noninfectious Uveitis.

Am J Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Department of Ophthalmology , Rabin Medical Center, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To investigate the clinical course and visual outcome of macular edema (ME) in pediatric patients with chronic noninfectious uveitis.

Design: Retrospective case series.

Methods: The databases of the uveitis clinics of four tertiary medical centers in Israel and the UK were searched for all children treated for uveitic ME in 2005-2015. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.011DOI Listing
February 2019

Brillouin Spectroscopy of Normal and Keratoconus Corneas.

Am J Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Wellman Center for Photomedicine - Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Purpose: To investigate the age-dependence of Brillouin spectroscopy of the cornea and to compare normal and keratoconus corneas.

Design: Retrospective case-control study STUDY POPULATION: Healthy patients and patients suffering from keratoconus seen at the Institut für Refraktive und Ophthalmo-Chirurgie (IROC) between December 2016 and March 2017.

Methods: Brillouin frequency shifts of patients of 2 different groups were examined with Brillouin spectroscopy perpendicular to the corneal surface. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.010DOI Listing
February 2019

Clinical Manifestations, Prognosis And Vaccination Status Of Patients With Rubella Virus-Associated Uveitis.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Purpose: To assess the clinical and laboratory manifestations and vaccination status of uveitis patients positive for Rubella virus (RV) in aqueous humor and investigate its relationship to Fuchs Uveitis Syndrome (FUS).

Methods: Retrospective study of all uveitis patients, positive for RV in aqueous humor analysis (polymerase chain reaction (PCR) and/or Goldmann-Witmer coefficient (GWC)) between January 2010 and October 2016 at the ophthalmology departments in the Erasmus Medical Center (Rotterdam) and University Medical Center Utrecht. Outcomes of aqueous analyses of FUS patients during this period were assessed. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.002DOI Listing
February 2019
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Correlation of Outer Retinal Degeneration and Choriocapillaris Loss in Stargardt disease using en face OCT and OCT Angiography.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Casey Eye Institute, Oregon Health & Science University, Portland, OR, United States. Electronic address:

Purpose: Measure and correlate degeneration of the inner segment/outer segment junction (IS/OS), retinal pigment epithelium (RPE) and choriocapillaris (CC) in Stargardt disease (STGD) DESIGN: Prospective cross-sectional study METHODS SETTING: Casey Eye Institute POPULATION: 23 patients with STGD PROCEDURES: OCT angiography (OCTA) scans were centered on the fovea. OCT slab projection and en face boundary maps were used to create masks to measure total IS/OS loss or RPE atrophy, as well as regions of isolated IS/OS loss, isolated RPE atrophy, matched IS/OS and RPE degeneration, or intact IS/OS and RPE. CC vascular density (CCVD) was quantified from CC angiogram. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.007DOI Listing
February 2019
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Identification and correction of restrictive strabismus following pterygium excision surgery.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Shiley Eye Institute and Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA. Electronic address:

Purpose: To report the characteristics of patients with restrictive diplopia following pterygium excision and a successful treatment approach for the strabismus.

Design: Retrospective interventional case series.

Methods Setting: Single academic institution. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.004DOI Listing
February 2019
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Randomized Trial of Treat & Extend Ranibizumab With & Without Navigated Laser versus Monthly Dosing for DME: TREX-DME 2 Year Outcomes.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Retina Consultants of Houston, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX.

Purpose: To prospectively evaluate a treat & extend algorithm of ranibizumab with and without navigated laser to monthly dosing for center-involving diabetic macular edema.

Design: Multicenter, randomized, clinical trial METHODS: 150 eyes were randomized into three cohorts: Monthly (n=30), TReat and EXtend without laser photocoagulation (TREX; n=60), and treat and extend with angiography-GuIded LAser photocoagulation (GILA; n=60). Monthly cohort eyes received ranibizumab 0. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.005DOI Listing
February 2019

Fluctuations of the intraocular pressure in medically versus surgically treated glaucoma patients by a contact lens sensor.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Translational Research in Respiratory Medicine; Arnau de Vilanova-Santa María University Hospital; IRBLleida, Catalonia, Spain.

Purpose: To compare fluctuations in intraocular pressure (IOP) in medically versus surgically treated glaucoma patients.

Design: Prospective, non-randomized case series.

Methods: IOP-related fluctuations were measured for 24 hours using a contact lens sensor (CLS). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.003DOI Listing
February 2019
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Longitudinal Study of Peripapillary Thinning in Sickle Cell Hemoglobinopathies.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL. Electronic address:

Purpose: To determine the rate of retinal nerve fiber layer (RNFL) thinning in patients with sickle cell hemoglobinopathies. Design; Prospective cohort study METHODS: Sixty-seven patients averaging 35.8±11. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.006DOI Listing
February 2019
2 Reads

The genetic influence on corticosteroid-induced ocular hypertension: A field positioned for discovery.

Am J Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114. Electronic address:

Purpose: To provide evidence that corticosteroid-induced ocular hypertension has a genetic component.

Design: Evidence-based Perspective.

Methods: We conducted a comprehensive literature search for studies exploring genetic influences on intraocular pressure responses to corticosteroid treatment. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.001DOI Listing
February 2019
1 Read

Diabetes Alone Does Not Impair Recovery From Uneventful Cataract Surgery.

Am J Ophthalmol 2019 Feb 8. Epub 2019 Feb 8.

Helsinki, Finland, and Kotka, Finland.

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http://dx.doi.org/10.1016/j.ajo.2019.01.007DOI Listing
February 2019

Multi-Step Grading System for Evaluation of Chronic Ocular Sequelae in Patients with Stevens-Johnson Syndrome.

Am J Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Vision Eye Institute, Royal Victorian Eye and Ear Hospital, North West Academic Centre, University of Melbourne, Australia.

Purpose: To propose a new scoring system for grading of chronic ocular sequelae in Stevens-Johnson syndrome (SJS).

Design: Reliability and validity analysis PARTICIPANTS: Four hundred eyes of 200 patients with chronic ocular SJS/TEN were included in the study.

Settings: Single centre, tertiary eye care referral centre METHODS: All patients of SJS/TEN with chronic (more than one year) ocular sequelae were recruited for the study. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.028DOI Listing
February 2019
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Effect of keratoconus severity on clinical outcomes after deep anterior lamellar keratoplasty.

Am J Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate the effect of keratoconus severity on the visual and refractive outcomes and complications after deep anterior lamellar keratoplasty (DALK).

Design: Consecutive interventional case series.

Methods: This study enrolled 227 keratoconus-affected eyes that underwent DALK. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.030DOI Listing
February 2019
1 Read

The location of exon 4 mutations in RP1 raises challenges for genetic counselling and gene therapy.

Am J Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, OX3 9DU; Nuffield Department of Clinical Neurosciences, Level 6, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU.

Purpose: Mutations in the photoreceptor gene RP1 lead to recessive or dominantly inherited retinitis pigmentosa (RP). Since the dominantly inherited phenotype is generally milder than recessive cases, it raises the possibility that it could arise by haploinsufficiency, however most mutations are in the terminal exon 4, which would be predicted to generate truncated proteins. We therefore assessed a cohort of RP patients with confirmed mutations in RP1 in order to examine the genetic basis of the exon 4 mutations. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.027DOI Listing
February 2019
1 Read

Rectus Extraocular Muscle Paths and Staphylomata in High Myopia.

Am J Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Stein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, U.S.A.; Department of Integrative Biology and Physiology, University of California, Los Angeles, U.S.A.; Department of Neurology, University of California, Los Angeles, U.S.A.; Neuroscience Interdepartmental Program, University of California, Los Angeles, U.S.A.; Bioengineering Interdepartmental Program, University of California, Los Angeles, U.S.A.. Electronic address:

Purpose: To investigate the relationship between displacement of extraocular muscles (EOMs) and staphyloma in high myopia using magnetic resonance imaging (MRI).

Design: Retrospective case-control study.

Methods: Setting: Institutional Study. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.029DOI Listing
February 2019

Deep anterior lamellar keratoplasty for keratoconus: multi-surgeon results.

Am J Ophthalmol 2019 Feb 2. Epub 2019 Feb 2.

Department of Corneal and External Eye Diseases, Moorfields Eye Hospital, London EC1V 2PD, United Kingdom. Electronic address:

Purpose: To examine clinical outcomes in deep anterior lamellar keratoplasty (DALK) for keratoconus using contemporary techniques in a multi-surgeon public healthcare setting.

Design: Consecutive, retrospective case series.

Setting: Moorfields Eye Hospital, London STUDY POPULATION: Consecutive cases of keratoconus treated with non-laser assisted DALK from September 1, 2012, to September 31, 2016. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.022DOI Listing
February 2019
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Estimated Prevalence and Incidence of Dry Eye Disease Based on Coding Analysis of a Large, All-age United States Health Care System.

Am J Ophthalmol 2019 Feb 2. Epub 2019 Feb 2.

Evidera|PPD, Waltham, MA Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA Department of Ophthalmology & Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address:

Purpose: To assess overall prevalence, annual prevalence and incidence of dry eye disease (DED) in a large, representative population in the US.

Design: Prevalence and incidence study METHODS: Retrospective analysis using the Department of Defense (DOD) Military Health System (MHS) data on beneficiary medical claims from United States DOD military and civilian facilities, January 1, 2003-March 31, 2015.

Patient Population: Using an algorithm, medical diagnostic codes indicative of DED and prescriptions for cyclosporine ophthalmic emulsion identified a DED population from 9. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.026DOI Listing
February 2019
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Distinguishing Highly Asymmetric Keratoconus Eyes Using Dual Scheimpflug/Placido Analysis.

Am J Ophthalmol 2019 Feb 2. Epub 2019 Feb 2.

Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA; USC Roski Eye Institute, Los Angeles, CA, USA. Electronic address:

Purpose: To identify the best metrics or combination of metrics that provide the highest predictive power between normal eyes and the clinically unaffected eye of patients with highly asymmetric keratoconus using data from a Dual Scheimpflug/Placido device DESIGN: Retrospective case-control study.

Methods: Combined Dual Scheimpflug/Placido imaging was obtained from the Galilei G 4 device (Ziemer Ophthalmic Systems AG; Port, Switzerland) in 31 clinically unaffected eyes with highly asymmetric keratoconus and 178 eyes from 178 patients with bilaterally normal corneal examinations that underwent uneventful LASIK with at least one year follow-up. Receiver operating characteristic (ROC) curves were generated to determine area under the curve (AUC), sensitivity, and specificity for 87 metrics, and logistic regression modeling was utilized to determine optimal variable combinations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193004
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http://dx.doi.org/10.1016/j.ajo.2019.01.023DOI Listing
February 2019
2 Reads

The Acanthamoeba- Fungal keratitis study.

Am J Ophthalmol 2019 Feb 2. Epub 2019 Feb 2.

Aravind Eye Hospital and Post-Graduate Institute of Ophthalmology, Coimbatore, India 641014.

Purpose: To ascertain the incidence of Acanthamoeba Keratitis, and the co-existence of Acanthamoeba & fungi in microbial keratitis Design; A prospective cross-sectional study METHODS: Patients presenting with stromal keratitis were additionally tested for Acanthamoeba irrespective of the clinical diagnosis. Culture positivity was the gold standard RESULTS: Of the 401 cases included in the study, 40 were positive for Acanthamoeba (10 %), 16 of these 40 were positive for both Acanthamoeba and fungi (4.5% of the Study Group was Acanthamoeba and fungal Keratitis positive); 5/40 for Acanthamoeba and bacteria; 2/40 had triple infection with Acanthamoeba, fungi and bacteria. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.024DOI Listing
February 2019
2 Reads

The Lens Opacities Classification System III grading in irradiated uveal melanomas to characterize proton induced cataracts.

Am J Ophthalmol 2019 Feb 2. Epub 2019 Feb 2.

Department of Radiation Oncology. Centre Francois Baclesse / ARCHADE- Normandie Université. 3 Avenue du Général Harris. BP 5026. 14076 Caen. France. Electronic address:

Purpose: To evaluate the use of the Lens Opacities Classification System III Grading (LOCS III) for the characterization of radiation-induced cataract, and to correlate the proton beam projection onto the lens with cataract location and grade as defined by the LOCS III.

Design: Prospective, interventional case series METHODS: Fifty-two consecutive patients with cataract following proton therapy were included. All cataracts were graded using LOCS III. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.025DOI Listing
February 2019
1 Read

Near-Infrared Autofluorescence in Choroideremia: Anatomic and Functional Correlations.

Am J Ophthalmol 2019 Mar 26;199:19-27. Epub 2018 Oct 26.

Department of Ophthalmology, University of Bonn, Bonn, Germany; Center for Rare Diseases Bonn (ZSEB), University of Bonn, Bonn, Germany; Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, and Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Electronic address:

Purpose: To investigate near-infrared fundus autofluorescence (NIR-AF) characteristics in patients with choroideremia and to correlate these with anatomic and functional parameters.

Design: Retrospective, observational case series.

Methods: In this multicenter study, 43 consecutive choroideremia patients (79 eyes) underwent multimodal retinal imaging, including near-infrared fundus autofluorescence (NIR-AF), blue autofluorescence (B-AF), optical coherence tomography (OCT), fundus photography, and functional testing including fundus-controlled microperimetry. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.10.021DOI Listing
March 2019
1 Read

Nuclear Factor Kappa-B is Enriched in Eyelid Specimens of Rosacea: Implications for Pathogenesis and Therapy.

Am J Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Department of Molecular and Cellular Physiology, Albany Medical College.

Purpose: To assess the role of nuclear factor kappa-B (NFKB) in cutaneous specimens of rosacea and unaffected tissue METHODS: Immunohistochemical staining was performed for the activated, phosphorylated variant of NFKB (pNFKB) in eyelid specimens of rosacea (n = 12) and normal, healthy tissue (n = 12). The numbers of positively-staining cells/40x microscopic field were counted across five consecutive fields. Additionally, quantitative western blotting was carried out for pNFKB and NFKB in specimens of rosacea (n = 15) and normal controls (n = 14). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.018DOI Listing
January 2019

Cataract Surgery and Rate of Visual Field Progression in Primary Open-Angle Glaucoma.

Am J Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA. Electronic address:

Purpose: To test the hypothesis that cataract surgery slows the apparent rate of visual field (VF) decay in primary open-angle glaucoma patients compared with rates measured during cataract progression.

Design: Retrospective cohort study.

Methods: Consecutive open-angle glaucoma patients who underwent cataract surgery and who had ≥4 VFs and ≥3 years of follow-up before and after surgery were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.019DOI Listing
January 2019
4 Reads

Frequency of Intraocular Lens Dislocation and Pseudophacodonesis, 20 Years After Cataract Surgery - A Prospective Study.

Authors:
Eva Mönestam

Am J Ophthalmol 2019 Feb 25;198:215-222. Epub 2018 Oct 25.

Department of Clinical Sciences/Ophthalmology, Faculty of Medicine, Umeå University, Umeå, Sweden. Electronic address:

Purpose: To examine the incidence and trends of late intraocular lens (IOL) dislocation/decentration and the frequency of pseudophakodonesis.

Design: Prospective, population-based cohort study.

Methods: A total of 800 patients were examined before cataract surgery in 1997-1998. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.10.020DOI Listing
February 2019

Prevalence of Diabetic Retinopathy and Associated Mortality Among Diabetic Adults With and Without Chronic Kidney Disease.

Am J Ophthalmol 2019 Feb 25;198:200-208. Epub 2018 Oct 25.

Division for Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Purpose: To estimate prevalence and severity of diabetic retinopathy (DR) among U.S. adults with diabetes and with or without chronic kidney disease (CKD), and assess associated risk of mortality. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.10.019DOI Listing
February 2019
1 Read

Earliest Evidence of Preclinical Diabetic Retinopathy Revealed using OCT Angiography (OCTA) Perfused Capillary Density.

Am J Ophthalmol 2019 Jan 25. Epub 2019 Jan 25.

Icahn School of Medicine at Mount Sinai, New York, NY, USA; Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.

Purpose: To compare perfused capillary density (PCD) in diabetic patients and healthy controls using optical coherence tomography angiography (OCTA).

Methods: Forty controls, 36 diabetics without clinical retinopathy (NoDR), 38 with nonproliferative retinopathy (NPDR), and 38 with proliferative retinopathy (PDR) were imaged using SD-OCT. A 3x3 mm full-thickness parafoveal OCTA scan was obtained from each participant. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.012DOI Listing
January 2019
1 Read

A Deep Learning Algorithm to Quantify Neuroretinal Rim Loss from Optic Disc Photographs.

Am J Ophthalmol 2019 Jan 25. Epub 2019 Jan 25.

Vision, Imaging and Performance (VIP) Laboratory, Duke Eye Center and Department of Ophthalmology, Duke University, Durham, NC. Electronic address:

Purpose: To train a deep learning (DL) algorithm that quantifies glaucomatous neuroretinal damage on fundus photographs using the minimum rim width relative to Bruch's membrane opening (BMO-MRW) from spectral domain-optical coherence tomography (SDOCT).

Design: Cross-sectional study METHODS: 9,282 pairs of optic disc photographs and SDOCT optic nerve head scans from 927 eyes of 490 subjects were randomly divided into the validation plus training (80%) and test sets (20%). A DL convolutional neural network was trained to predict the SDOCT BMO-MRW global and sector values when evaluating optic disc photographs. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.011DOI Listing
January 2019

Acute Vascular Ischemic Events in Patients with Central Retinal Artery Occlusion in the United States: A Nationwide Study 2003-2014.

Am J Ophthalmol 2019 Jan 25. Epub 2019 Jan 25.

West Virginia University School of Medicine, 1 Medical Center Drive, Morgantown, WV.

Purpose: Central retinal artery occlusion (CRAO) confers a high risk of acute vascular ischemic events, including stroke and myocardial infarction (MI). Understanding the burden and risk factor profile of these ischemic events can serve as a valuable guide for ophthalmologists in the management and appropriate referral of these patients.

Design: Retrospective cross-sectional study METHODS: The Nationwide Inpatient Sample (NIS) was queried to identify all inpatient admissions with a diagnosis of CRAO in the United States between the years 2003 to 2014. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.009DOI Listing
January 2019
1 Read

Five-year cumulative incidence and risk factors of Nd:YAG capsulotomy in 10044 hydrophobic acrylic 1-piece and 3-piece IOLs.

Am J Ophthalmol 2019 Jan 25. Epub 2019 Jan 25.

Helsinki Retina Research Group, University of Helsinki, Helsinki, Finland; Kymenlaakso Central Hospital, Unit of Ophthalmology, Kotka, Finland. Electronic address:

Purpose: To evaluate the 5-year cumulative incidence and risk factors of Nd:YAG capsulotomy between hydrophobic acrylic intraocular lenses (IOLs).

Design: A retrospective cohort study.

Methods: A review of the registry of operations between the years 2007-2016 was carried out at the Ophthalmology Unit of Kymenlaakso Central Hospital, Kotka, Finland. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193002
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http://dx.doi.org/10.1016/j.ajo.2019.01.010DOI Listing
January 2019
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Corneal Epithelial Thickness Intrasubject Repeatability and its Relation with Visual Limitation in Keratoconus.

Am J Ophthalmol 2019 Jan 25. Epub 2019 Jan 25.

Department of Cornea and Refractive Surgery, Vissum, Alicante, Spain; Keratoconus Unit of Vissum, Alicante, Spain; Division of Ophthalmology, Universidad Miguel Hernández, Alicante, Spain.

Purpose: To evaluate intra-subject repeatability of anterior segment optical coherence tomography (AS-OCT) combined with placido disc MS-39 (CSO, Firenze, Italy) and correlate epithelial thickness measurements and the degree of visual limitation in keratoconus patients.

Design: Reliability analysis and cross-sectional study.

Setting: Vissum, Alicante, Spain. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.015DOI Listing
January 2019

Peripapillary versus macular combined hamartoma of the retina and retinal pigment epithelium: Imaging characteristics.

Am J Ophthalmol 2019 Jan 26. Epub 2019 Jan 26.

Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad-34, India. Electronic address:

Purpose: To compare clinical, optical coherence tomography (OCT), and fundus autofluorescence (FAF) characteristics of peripapillary versus (vs.) macular variants of combined hamartoma of the retina and retinal pigment epithelium (combined hamartoma).

Design: Retrospective observational, comparative case series METHODS:SETTING: Multicentre collaborative study STUDY POPULATION: 50 eyes with a clinical diagnosis of combined hamartoma OBSERVATIONAL ANALYSIS: A comparative analysis of color fundus photographs (CFPs), OCT and FAF was performed for peripapillary and macular variants of combined hamartoma. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.016DOI Listing
January 2019
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What the American Journal of Ophthalmology Wants to Publish.

Am J Ophthalmol 2019 Mar 24;199:xi-xii. Epub 2019 Jan 24.

American Journal of Ophthalmology, Saint Augustine, Florida, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183067
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http://dx.doi.org/10.1016/j.ajo.2018.12.005DOI Listing
March 2019
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Anatomic, Visual and Financial Outcomes for Traditional and Nontraditional Primary Pneumatic Retinopexy for Retinal Detachment.

Am J Ophthalmol 2019 Jan 23. Epub 2019 Jan 23.

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia College of Physicians and Surgeons, New York, NY, USA; Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical School, Singapore.

Purpose: To determine factors predictive of anatomic, visual and financial outcomes after traditional and nontraditional primary pneumatic retinopexy (PR) for rhegmatogenous retinal detachment (RD).

Design: Retrospective interventional case series and cost comparison Methods: PARTICIPANTS: 178 eyes (156 patients) with PR-repaired primary RD by a single surgeon at a clinical practice from 1/2001-12/2013 and followed for ≥1 year. The cohort had 2 sub-groups: traditional (TPR) and nontraditional (NTPR) PR. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.008DOI Listing
January 2019
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Treatment Duration and Side Effect Profile of Long-term Use of Intravitreal Preservative-free Triamcinolone Acetonide in Uveitis.

Authors:
Gary D Novack

Am J Ophthalmol 2019 Jan 22. Epub 2019 Jan 22.

Sacramento, California, USA, and San Rafael, California, USA.

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http://dx.doi.org/10.1016/j.ajo.2018.11.025DOI Listing
January 2019

Extended (≥q12 Weeks) Dosing Interval With Intravitreal Aflibercept and Ranibizumab in Neovascular AMD: Post Hoc Analysis of VIEW Trials.

Am J Ophthalmol 2019 Jan 19. Epub 2019 Jan 19.

Retina-Vitreous Associates Medical Group, Beverly Hills, CA. Electronic address:

Purpose: To evaluate outcomes and disease characteristics in eyes with neovascular age-related macular degeneration that received intravitreal aflibercept injection (IAI) and ranibizumab ≥q12 or
Design: Post-hoc analysis of randomized clinical trial data.

Methods: In year 1, eyes received ranibizumab q4 weeks (Rq4), IAI 2 mg q4 weeks (2q4), or IAI 2 mg q8 weeks after 3 monthly injections (2q8). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.005DOI Listing
January 2019
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Prosthetic Replacement of the Ocular Surface Ecosystem Treatment for Ocular Surface Disease in Pediatric Patients with Stevens-Johnson Syndrome.

Am J Ophthalmol 2019 Jan 18. Epub 2019 Jan 18.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Electronic address:

Purpose: To report the outcomes of Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) treatment in pediatric patients with chronic ocular surface disease associated with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).

Design: Retrospective, interventional case series METHODS: Patients ages 18 or younger seen in consultation for PROSE treatment at a single center between January 1992 and December 2016 with a history of SJS/TEN were reviewed. Demographics, etiology of SJS/TEN, age at treatment milestones, best corrected visual acuity (BCVA) at treatment milestones and treatment failures were recorded. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.006DOI Listing
January 2019
3 Reads