26,343 results match your criteria American journal of ophthalmology[Journal]


Direct Versus Indirect Corneal Neurotization for the Treatment of Neurotrophic Keratopahty: a Multicenter Prospective Comparative Study.

Am J Ophthalmol 2020 Jul 10. Epub 2020 Jul 10.

Unit of Maxillofacial Surgery, Head and Neck Department, ASST Santi Paolo e Carlo Hospital, University of Milan, Milan, Italy.

Purpose: To analyze the comparative safety and efficacy of two techniques of corneal neurotization (CN) (direct corneal neurotization [DCN] vs indirect corneal neurotization [ICN] for the treatment of neurotrophic keratopathy (NK).

Design: Multicenter Interventional Prospective Comparative Case Series.

Methods: Setting: ASST Santi Paolo e Carlo University Hospital, Milan; S. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.07.003DOI Listing

Three-Year Outcomes of Tri-Folded Endothelium-In Descemet Membrane Endothelium Keratoplasty with Pull-Through Technique.

Am J Ophthalmol 2020 Jul 10. Epub 2020 Jul 10.

University of Ferrara, Department of Morphology, Surgery and Experimental Medicine, Ferrara, Italy;; Ospedali Privati Forlì"Villa Igea", Department of Ophthalmology, Forlì, Italy;; Istituto Internazionale per la Ricerca e Formazione in Oftalmologia (IRFO), Forlì, Italy;. Electronic address:

Purpose: To report the 3-year outcomes of tri-folded, endothelium-in Descemet membrane endothelial keratoplasty (DMEK) using bimanual pull-through delivery technique.

Design: Interventional case series METHODS: In this single center study, 153 consecutive eyes undergoing DMEK for various indications (Fuchs endothelial corneal dystrophy (FECD) n=111; bullous keratopathy (BK) n=24; failed grafts n=18) were included. DMEK grafts were loaded into a disposable cartridge in tri-folded, endothelium-in configuration and delivered using bimanual pull-through technique. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.07.004DOI Listing

Temporal Raphe Sign in Elderly Patients with Large Optic Disc Cupping: Its Evaluation as a Predictive Factor for Glaucoma Conversion.

Am J Ophthalmol 2020 Jul 8. Epub 2020 Jul 8.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea. Electronic address:

Purpose: To determine baseline clinical features associated with conversion to glaucoma in elderly patients with large optic-disc cupping DESIGN: Retrospective cohort study.

Methods: Seventy-two (72) eyes of 72 untreated elderly (65+ year old) patients with large vertical cup-to-disc ratio (CDR ≥ 0.7) and without any other glaucomatous findings were included. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.07.001DOI Listing

Comment on Accuracy of Intraocular Lens Formulas in Eyes With Keratoconus.

Am J Ophthalmol 2020 Jul 6. Epub 2020 Jul 6.

Department of Cornea and Refractive Surgery, Instituto de Oftalmología "Conde de Valenciana", Mexico City, Mexico.

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http://dx.doi.org/10.1016/j.ajo.2020.04.030DOI Listing

A Randomized Controlled Trial Comparing Subconjunctival Injection to Direct Scleral Application of Mitomycin C in Trabeculectomy.

Am J Ophthalmol 2020 Jul 6. Epub 2020 Jul 6.

Hamilton Glaucoma Center, Shiley Eye Institute and Viterbi Family Department of Ophthalmology, University of California, San Diego, CA, USA. Electronic address:

Purpose: To compare the efficacy of intraoperative scleral application with subconjunctival injection of mitomycin C (MMC) in trabeculectomy.

Design: Prospective, randomized, interventional study.

Participants: Subjects with medically uncontrolled glaucoma as indicated by high intraocular pressure (IOP), worsening visual field, or optic nerve head changes in whom primary trabeculectomy is indicated. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.07.002DOI Listing

Sex Differences in the Repair of Retinal Detachments in the United States.

Am J Ophthalmol 2020 Jul 5. Epub 2020 Jul 5.

Byers Eye Institute at the Stanford University School of Medicine, Palo Alto, CA.

Purpose: To determine differences between women and men in the repair of rhegmatogenous retinal detachments (RRD) in the United States.

Design: Retrospective cohort study.

Methods: SETTING: A large insurance claims database. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.039DOI Listing

The Short-Term Effect of a Single Lapse in Anti-Vascular Endothelial Growth Factor Treatment for Diabetic Macular EdemaWithin Routine Clinical Practice.

Am J Ophthalmol 2020 Jul 5. Epub 2020 Jul 5.

Case Western Reserve University School of Medicine, Cleveland, OH; Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, OH. Electronic address:

Purpose: Diabetic macular edema (DME) is a leading cause of vision loss in diabetics. Anti-vascular endothelial growth factor (VEGF) therapy has been shown to be an effective treatment option for DME, although the injections are costly and require frequent visits which increases the risk for unintended treatment lapses. The aim of this study is to characterize the effects of an unintended treatment lapse in patients with DME undergoing anti-VEGF therapy. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335491PMC

EvaluatingGoldmann applanation tonometryintraocular pressure measurement agreement between ophthalmic technicians and physicians.

Am J Ophthalmol 2020 Jul 5. Epub 2020 Jul 5.

Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, USA; The Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, USA. Electronic address:

Purpose: To examine IOP measurement disagreement between technicians and physicians and the impact of an educational intervention on the short and long-term disagreement in IOP measurement using Goldmann applanation tonometry.

Design: Prospective Study designed to enhance measurement reliability SETTING: A glaucoma clinic at a university hospital STUDY POPULATION: 6 technicians and 2 physicians INTERVENTION: An educational intervention was implemented for the technicians to improve IOP measurement agreement with physicians.

Main Outcome Measures: Frequency of IOP measurement disagreement between physicians and technicians, defined as a difference in IOP of >2 or >3 mmHg and assessed at baseline, immediately- and 6-months post-intervention. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.041DOI Listing

Authors:

Am J Ophthalmol 2020 Jul 3. Epub 2020 Jul 3.

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http://dx.doi.org/10.1016/j.ajo.2020.02.018DOI Listing

Incidence and outcome of uveitic glaucoma in eyes with intermediate, posterior or panuveitis followed up to 10 years after randomization to fluocinolone acetonide implant or systemic therapy.

Am J Ophthalmol 2020 Jul 3. Epub 2020 Jul 3.

the Center for Clinical Trials and Evidence Synthesis; Departments of Epidemiology; The Johns Hopkins University School of Medicine Wilmer Eye Institute.

Purpose: To evaluate long-term risk and outcomes of glaucoma in eyes with intermediate, posterior, and panuveitis managed with systemic or fluocinolone acetonide (0.59 mg, "implant") therapy.

Design: Prospective Follow-up of the Multicenter Uveitis Steroid Treatment (MUST) Clinical Trial Cohort METHODS: Patients with intermediate, posterior or panuveitis randomized to implant or systemic therapy (corticosteroid plus immunosuppression in >90%) were followed prospectively for glaucoma incidence and outcome. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.038DOI Listing

Long-term invivo stability of posterior chamber phakic intraocular lens: properties and light transmission characteristics of explants.

Am J Ophthalmol 2020 Jul 2. Epub 2020 Jul 2.

Chukyo Eye Clinic, Nagoya, Japan.

Purpose: To evaluate the in vivo durability of the surface and optical properties of the implantable Collamer lens (ICL).

Design: Retrospective case series.

Methods: We included patients who developed cataracts after having undergone ICL implantation from March 2003 to May 2014 and underwent ICL explantation followed by cataract surgery from March 2017 to December 2019 at the Nagoya Eye Clinic. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.025DOI Listing

Comparison of Toric Implantable Collamer Lens and Toric Artiflex Phakic IOLs in terms of Visual Outcome, A paired Contralateral Eye Study.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

Parsian Vision Science Research Institute, Isfahan, Iran.

Purpose: To compare the postoperative visual outcomes of toric implantable collamer lens (T-ICL) and toric Artiflex (T-Artiflex) implantation.

Design: Alternating-treatment, contralateral eye matched clinical study METHODS: This study compared 82 eyes of 41 patients with toric ICL implantation in one eye and toric Artiflex implantation in the contralateral eye to correct myopic astigmatism. Safety, efficacy, predictability, astigmatic vector changes, contrast sensitivity, endothelial cell count, and possible adverse events were assessed at least 12 months postoperatively. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.021DOI Listing

Real-World Outcomes of DMEK: A Prospective Dutch Registry Study.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

University Eye Clinic, Maastricht University Medical Center+, Maastricht, the Netherlands.

Purpose: To analyze real-world practice patterns, graft survival, and outcomes of Descemet membrane endothelial keratoplasty (DMEK) in the Netherlands.

Design: Population-based interventional clinical study.

Methods: In this prospective registry study, all consecutive primary DMEK procedures registered in the Netherlands Organ Transplant Registry were identified. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.023DOI Listing

The Aravind Pseudoexfoliation Study (APEX): 5-year Post-Operative Results. The Effect of IOL Choice and Capsular Tension Rings.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

Wilmer Eye Institute and Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland; Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan. Electronic address:

Purpose: We compared rates of IOL decentration, Nd:YAG capsulotomy for posterior capsule opacification (PCO), and visual acuity (VA) in eyes with and without pseudoexfoliation (PEX) 5 years after undergoing cataract surgery.

Design: Prospective comparative interventional study METHODS: .

Setting: Multicenter STUDY POPULATION: One eye of both 930 cataract patients with, and 470 cataract patients without, uncomplicated PEX (no small pupils or phacodonesis) all undergoing phacoemulsification by experienced Aravind Eye Care System surgeons. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.031DOI Listing

Prevalence and Consequences of Perceived Vision Difficultyin Aging Adults with HIV-infection.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

Department of Medicine, Division of Infectious Diseases, Georgetown University, Washington DC.

Purpose: Despite well-known ocular complications of HIV-related immune suppression, few studies have examined the prevalence and consequences of visual impairment among aging long term survivors of HIV.

Design: Retrospective cohort study METHODS: Aging HIV-infected (HIV+) men who have sex with men (MSM) and -uninfected (HIV-) MSM controls reported their difficulty performing six vision-dependent tasks (no, a little, moderate, and extreme difficulty). Relationships were examined using logistic regression, regressing each outcome separately on categorical visual function responses, with missing data multiply imputed. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.018DOI Listing

Ability of 24-2C and 24-2 grids in identifying central visual field defects and structure-function concordance in glaucoma and suspects.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

Centre for Eye Health, University of New South Wales, Kensington, NSW; School of Optometry and Vision Science, University of New South Wales, Kensington, NSW.

Purpose: To compare the ability of 24-2 and 24-2C test grids in measuring visual field global indices, identifying central visual field defects and facilitating macular structure-function analysis with optical coherence tomography (OCT) scans in glaucoma suspects and glaucoma patients.

Design: Prospective, cross-sectional study PARTICIPANTS: One eye from 100 glaucoma suspect and glaucoma patients (60 undergoing SITA-Faster testing on 24-2 and 24-2C; 40 undergoing SITA-Standard testing on 24-2 and SITA-Faster on 24-2C) were included in the study. Global visual field indices, test duration and pattern deviation results were extracted. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.024DOI Listing

Validation of a Compensation Strategy used to Detect Choriocapillaris Flow Deficits Under Drusen with Swept Source OCT Angiography.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA. Electronic address:

Purpose: A compensation strategy that was developed to measure the choriocapillaris (CC) flow deficits (FDs) under drusen was tested in eyes with large drusen from age-related macular degeneration (AMD) before and after the drusen spontaneously resolved without evidence of disease progression.

Design: Prospective, observational consecutive case series.

Methods: Patients with AMD were enrolled in a prospective SS-OCT imaging study (PLEX® Elite 9000, Carl Zeiss Meditec). Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.033DOI Listing

Eliminating Visual Acuity and Dilated Fundus Exams Improves Cost Efficiency of Performing OCT-Guided Intravitreal Injections.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller, School of Medicine, Miami, Florida, USA. Electronic address:

Purpose: The clinic efficiency and cost savings achieved by eliminating formal visual acuity (VA) and dilated fundus exams (DFEs) were assessed for established patients receiving OCT-guided intravitreal injections.

Design: Comparative cost analysis METHODS: Two different treatment models were evaluated. The first model included patients undergoing routine VA assessment, DFEs, OCT imaging, and intravitreal injections. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329678PMC

Paracentral and Cecocentral Scotomas after Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

University of Southern California Roski Eye Institute, Los Angeles, California.

Purpose: To describe novel paracentral and cecocentral visual scotomas after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) repair over a five-year time period.

Design: Retrospective Case Series METHODS: This was a retrospective review of all patients who reported visual scotomas after 23-gauge or 25-gauge PPV (CONSTELLATION® Vision System, Alcon, Ft. Worth, TX) for RRD repair by a single surgeon (RNK) from January of 2013 through December of 2018. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.026DOI Listing

Effect of 3-hydroxy-3-methyl-glutaryl-coenzyme A Reductase Inhibitors on the Meibomian Gland Morphology in Patients with Dyslipidemia.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Purpose: Prior studies suggested an association between dyslipidemia and meibomian gland dysfunction (MGD). The aim of this prospective, non-randomized clinical study is to evaluate the possible association of dyslipidemia and its treatment with meibomian gland (MG) morphological changes by standardized meibography.

Design: Prospective, non-randomized clinical study METHODS: Two groups of participants were enrolled: group 1, patients under regular 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor (statin) treatment for dyslipidemia, and the group 2, those with newly diagnosed dyslipidemia who were under lifestyle interventions. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.029DOI Listing

Exudative Retinal Detachment in Ocular Inflammatory Diseases: Risk and Predictive Factors.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts; MyungSung Christian Medical Center (MCM) Eye Unit, MCM General Hospital and MyungSung Medical School, Addis Ababa, Ethiopia.

Purpose: To evaluate the risk/risk factors for exudative retinal detachment (ERD) in ocular inflammatory diseases.

Design: Retrospective cohort study.

Methods: Patients with non-infectious ocular inflammation had been followed longitudinally between 1978-2007 at four US subspecialty uveitis centers. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.019DOI Listing

Comment On: Accuracy of Intraocular Lens Formulas in Eyes With Keratoconus.

Am J Ophthalmol 2020 Jun 30. Epub 2020 Jun 30.

Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/j.ajo.2020.04.031DOI Listing

Genotype-phenotype correlations in a Spanish cohort of 506 families with bi-allelic ABCA4 pathogenic variants.

Am J Ophthalmol 2020 Jun 30. Epub 2020 Jun 30.

Department of Genetics, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain. Electronic address:

Purpose: To define genotype-phenotype correlations in the largest cohort study worldwide of patients: 434 with Stargardt disease (STGD1) and 72 with cone-rod dystrophy (CRD), all carrying biallelic ABCA4 variants.

Design: Cohort study.

Methods: We characterized 506 patients with ABCA4 variants using conventional genetic tools and Next Generation Sequencing technologies. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.027DOI Listing

Long-term outcomes of Descemet membrane endothelial keratoplasty in eyes with prior glaucoma surgery.

Am J Ophthalmol 2020 Jun 30. Epub 2020 Jun 30.

Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, California, USA. Electronic address:

Purpose: To evaluate the long-term outcomes of Descemet membrane endothelial keratoplasty (DMEK) in eyes with prior trabeculectomy and/or drainage device.

Design: Retrospective, noncomparative case series.

Methods: Medical records of 251 consecutive DMEK procedures performed by 1 surgeon (SXD) from 2013 to 2017 were reviewed. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.022DOI Listing

Rethinking the Hydroxychloroquine Dosing and Retinopathy Screening Guidelines.

Am J Ophthalmol 2020 Jun 28. Epub 2020 Jun 28.

Rhode Island Eye Institute, 150 East Manning St., Providence, RI 02906.

Purpose: To describe the rationale for revising the hydroxychloroquine (HCQ) dosing and screening guidelines and to identify the barriers to more effective guidelines in the future.

Design: Literature review.

Methods: A PubMed query of studies on HCQ dosing and hydroxychloroquine retinopathy (HCQR) screening was done with a selective review of the English language literature. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.030DOI Listing

Choroidal thickness in diabetic patients without diabetic retinopathy: a meta-analysis.

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan.

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http://dx.doi.org/10.1016/j.ajo.2020.05.036DOI Listing

Postoperative complications in Medicare beneficiaries following endothelial keratoplasty (EK) surgery.

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

The Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

Purpose: To determine national-level incidence rates of major postoperative complications following EK procedures, and to stratify these rates based on EK indications over an 8-year period using Medicare claims data.

Design: Retrospective, cohort study METHODS: .

Setting: Population-based STUDY POPULATION: Medicare beneficiaries aged ≥65 years who underwent EK procedures MAIN OUTCOME MEASURE(S): 1) Occurrence of major postoperative complications (i. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.05.033DOI Listing
June 2020
3.871 Impact Factor

Age-related Macular Degeneration: Nutrition, Genes and Deep Learning-The LXXVIEdward Jackson Memorial Lecture.

Authors:
Emily Y Chew

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute/National Institutes of Health. Electronic address:

Purpose: To evaluate the importance of nutritional supplements, dietary pattern, and genetic associations in age-related macular degeneration (AMD); and to discuss; the technique of artificial intelligence/deep learning to potentially enhance research in detecting and classifying AMD.

Design: Retrospective literature review METHODS: To review the studies of both prospective and retrospective (post-hoc) analyses of nutrition, genetic variants, deep learning in AMD in both the Age-Related Eye Disease Study (AREDS) and AREDS2 RESULTS: In addition to demonstrating the beneficial effects of the AREDS and AREDS2 supplements of antioxidant vitamins and zinc (plus copper) for reducing the risk of progression to late AMD, these two studies also confirmed the importance of high adherence to Mediterranean diet in reducing progression of AMD in persons with varying severity of disease. In persons with the protective genetic alleles of Complement Factor H (CFH), the Mediterranean diet had further beneficial effect. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.05.042DOI Listing

Lymphoma of the lacrimal gland - An International Multicenter Retrospective Study.

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

Eye Pathology Section, Department of Pathology, Rigshospitalet, University of Copenhagen, Denmark; Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Denmark. Electronic address:

Purpose: To characterize the clinical features of subtype-specific lacrimal gland lymphoma and their effect on patient survival.

Design: Multi-center retrospective interventional case series.

Methods: Patient data were collected from 6 international eye cancer centers from January 1, 1980 through December 31, 2017. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.015DOI Listing

Exploratory use of fluorescent SmartProbes for the rapid detection of microbial isolates causing corneal ulcer.

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, EH16 4TJ, UK. Electronic address:

Purpose: To explore the use of optical SmartProbes for the rapid evaluation of corneal scrapes from patients with suspected microbial keratitis, as a clinical alternative to Gram stain.

Design: Experimental study with evaluation of a diagnostic technology.

Methods: Corneal scrapes were collected from 267 patients presenting with microbial keratitis at a referral cornea clinic in South India. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.014DOI Listing

'Descemet's membrane detachment': A novel concept in diagnosis and classification.

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

Academic section of Ophthalmology, Division of clinical neuroscience, University of Nottingham, Nottingham University Hospitals, NHS Trust. Nottingham, UK.

Purpose: To examine the optical coherence tomography (OCT) and histological features of Descemet's membrane detachment (DMD) to ascertain the involvement of the pre-Descemet's layer (PDL).

Design: Retrospective, observational case series.

Methods: Clinical, histopathological and OCT features of a cohort of forty-one cases with diagnosis of DMD from four centres were studied. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.05.038DOI Listing

Clinical manifestation and risk factors associated with remission in patients with filamentary keratitis.

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

The Institute of Ophthalmology and Optometry, Department of Ophthalmology, EwhaWomans University College of Medicine, Mokdong Hospital, Seoul, South Korea,. Electronic address:

Purpose: This study investigated the clinical manifestation and risk factors associated with remission in filamentary keratitis.

Design: Retrospective, interventional, comparative case series.

Methods: We retrospectively reviewed the medical records of 116 patients with filamentary keratitis diagnosed and treated between January 2012 and December 2018. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.05.037DOI Listing

Diagnostic Accuracy of Wide-Field Map from Swept-Source Optical Coherence Tomography for Primary Open-Angle Glaucoma in Myopic Eyes.

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

Department of Ophthalmology, SeoulNationalUniversityHospital, SeoulNationalUniversityCollege of Medicine, Seoul, Korea. Electronic address:

Purpose: To compare the accuracy for glaucomatous defects and diagnostic power for primary open-angle glaucoma (POAG) between swept-source optical coherence tomography (SS-OCT) and spectral-domain optical coherence tomography (SD-OCT) in myopic eyes.

Design: Prospective, case-control study METHODS: One hundred and fifty (150) myopic POAG eyes and 100 healthy myopic eyes underwent SD-OCT and SS-OCT in random order, on the same day. The locations of glaucomatous defect on SD-OCT thickness and deviation maps and SS-OCT wide-field thickness (thickness surface) and SuperPixel maps were rated, and the maps' accuracies were compared. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.05.032DOI Listing
June 2020
3.871 Impact Factor

Factors associated with improvement in vision following femtosecond astigmatic keratotomy in post keratoplasty keratoconus patients.

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

The University of Toronto, Department of Ophthalmology and Vision Sciences, Toronto, Canada.

Purpose: To report factors associated with improvement in vision following femtosecond astigmatic keratotomy (FSAK) in post keratoplasty keratoconus patients.

Design: Retrospective, interventional case series.

Methods: Setting: Institutional. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.007DOI Listing

Macular and Peripapillary OCTA Metrics Predict Progression in Diabetic Retinopathy: A Sub-analysis of TIME-2b Study Data.

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

New England Eye Center, 260 Tremont Street, Boston, MA. Electronic address:

Purpose: To identify optical coherence tomography angiography (OCTA) derived vessel metrics of the macula and optic nerve head (ONH) that predict diabetic retinopathy (DR) disease progression.

Design: Secondary analysis of clinical trial data METHODS: This was a sub-analysis of prospectively collected data from 73 subjects that participated in the TIME-2b Study (Aerpio Pharmaceuticals), a multi-center clinical trial for patients with moderate to severe DR treated with AKB-9778 and followed over a 12-month period. Eligible subjects were tested every 3 months with color fundus photography, spectral domain OCT and slit-lamp biomicroscopy. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.009DOI Listing

Fellowship Match Outcomes in the U.S. from 2010-2017: Analysis of San Francisco (SF) Match.

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

The Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Purpose: To describe applicant characteristics and outcomes associated with the ophthalmology fellowship match.

Design: Retrospective case-control study.Methods SETTING: : San Francisco (SF) Matching data for ophthalmology fellowship applicants in the U. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.008DOI Listing
June 2020
3.871 Impact Factor

Bruch's membrane opening minimum rim width provides objective differentiation between glaucoma and non-glaucomatous optic neuropathies.

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

Faculty of Medicine, Sydney University, Sydney, Australia; Sydney Eye Hospital, Sydney, Australia.

Purpose: A challenging clinical scenario is distinguishing between normal tension glaucoma (NTG) and non-glaucomatous optic neuropathies (NGON). Key to the assessment remains assessing for the presence of optic nerve head cupping. Recent optical coherence tomography (OCT) measures now allow objective assessment of cupping by BMO-MRW. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.05.034DOI Listing

Mycoplasma Pneumoniae Induced Rash and Mucositis (MIRM): A Longitudinal Perspective and Proposed Management Criteria.

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

Purpose: To evaluate the natural history and ophthalmologic morbidity of Mycoplasma pneumoniae induced rash and mucositis (MIRM) and propose a treatment algorithm.

Design: Retrospective, interventional case series METHODS: Retrospective chart review of all MIRM patients examined by the department of ophthalmology at a tertiary children's hospital. Diagnosis was established clinically concomitant with either positive Mycoplasma pneumoniae IgM or PCR testing from January 1 2010 until December 31 2019. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.010DOI Listing

The Effect of Obstructive Sleep Apnea on Absolute Risk of Central Serous Chorioretinopathy.

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

Byers Eye Institute, Department of Ophthalmology, Stanford University. Electronic address:

Purpose: To determine the incidence of central serous chorioretinopathy (CSC) stratified by age, sex, and diagnosis with obstructive sleep apnea (OSA), and to determine whether some patients with newly diagnosed CSC may be candidates for OSA evaluation.

Design: Retrospective cohort study.

Methods: We used the IBM Marketscan database to select 59,016,145 commercially-insured patients in the United States between 2007 and 2016. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.05.040DOI Listing

Repeatability of the Pentacam HR in various grades of keratoconus.

Am J Ophthalmol 2020 Jun 19. Epub 2020 Jun 19.

Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium; Department of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.

Purpose: To evaluate the repeatability of an extensive number of relevant indices with the Pentacam HR in keratoconus of varying severity and normal eyes.

Design: Reliability analysis METHODS: This study was performed at Antwerp University Hospital, Belgium, and enrolled 20 healthy volunteers (20 eyes) and 69 patients (69 eyes) with keratoconus. Three consecutive measurements were performed by the same operator with Pentacam HR in keratoconus and normal eyes. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.013DOI Listing

Ocular Manifestations and Burden Related To Sjögren's Syndrome: Results of a Patient Survey.

Am J Ophthalmol 2020 Jun 19. Epub 2020 Jun 19.

Professor, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland USA.

Purpose: (1) Compare the burden related to dry eye with systemic symptoms of Sjögren's; (2) Estimate the burden related to ocular treatments; and (3) Compare the impact of dry eye and extraocular manifestations of Sjögren's on various aspects of patient life.

Design: Cross-sectional study.

Methods: We conducted of postal survey of adult patients with a history of physician-diagnosed Sjögren's. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.05.043DOI Listing

Effect of Prematurity on Foveal Development in Early School-Age Children.

Am J Ophthalmol 2020 Jun 19. Epub 2020 Jun 19.

Department of Ophthalmology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Purpose: To evaluate the foveal development in preterm children with optical coherence tomography (OCT) and OCT angiography (OCTA).

Design: Retrospective cohort study.

Methods: This study consisted of children aged 6-8 years who were prematurely born and did not receive retinopathy treatment. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.001DOI Listing

Unplanned Return to the Operating Room after Trabeculectomy.

Am J Ophthalmol 2020 Jun 19. Epub 2020 Jun 19.

Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Purpose: To determine the unplanned return to OR rate within 180 days and at any time postoperatively after trabeculectomy performed or supervised by an attending surgeon and to identify associated factors DESIGN: Retrospective case-control study METHODS: Review of 881 eyes that underwent trabeculectomy at an academic glaucoma service between 01/2014-12/2016. Inclusion criteria included adult patients with postoperative follow-up >180 days and no other glaucoma-related surgery within the prior year. For each eye that underwent reoperation, a control was time-matched within one month. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.016DOI Listing

From conventional angle surgery to 360-degree trabeculotomy in pediatric glaucoma.

Am J Ophthalmol 2020 Jun 19. Epub 2020 Jun 19.

Glaucoma department. Moorfields Eye Hospital. London, United Kingdom. Electronic address:

Purpose: To describe the transition from conventional angle surgery (CAS): trabeculotomy with rigid probe or goniotomy, to 360-degree trabeculotomy assisted with microcatheter (MCT).

Design: Retrospective comparative interventional case series.

Methods: Review of consecutive children with glaucoma undergoing angle surgery including cases with previous surgery, from January 2012 until March 2018 at Moorfields Eye Hospital. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.017DOI Listing

Cost-Utility Analysis of VEGF-Inhibitors for Treating Neovascular Age-Related Macular Degeneration.

Am J Ophthalmol 2020 Jun 19. Epub 2020 Jun 19.

Retina-Vitreous Associates Medical Group, Los Angeles, CA.

Purpose: To perform 11-year and 2-year, healthcare sector (ophthalmic) and societal cost perspective reference case, cost-utility analyses comparing bevacizumab, ranibizumab and aflibercept monotherapies for neovascular age-related macular degeneration (NVAMD).

Design: Cost-utility analysis METHODS: Average and incremental reference case analyses with ophthalmic and societal cost perspectives. Patient utilities, bilateral outcomes, 2018 U. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.05.029DOI Listing

Capillary Density Measured by OCT Angiography in Glaucomatous Optic Disc Phenotypes.

Am J Ophthalmol 2020 Jun 16. Epub 2020 Jun 16.

Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, CA, United States. Electronic address:

Purpose: To compare optical coherence tomography angiography (OCTA) measured capillary density of the optic disc among four glaucomatous optic disc phenotypes.

Design: Cross-sectional study.

Methods: Circumpapillary capillary density (cpCD) of four glaucomatous optic disc phenotypes in 193 eyes of 141 glaucoma patients and cpCD in 92 eyes of 55 healthy subjects from the Diagnostic Innovations in Glaucoma Study (DIGS) were compared. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.012DOI Listing