25,815 results match your criteria American journal of ophthalmology[Journal]


Post-Concussion: Receded Near Point of Convergence is Not Diagnostic of Convergence Insufficiency.

Am J Ophthalmol 2019 Apr 17. Epub 2019 Apr 17.

Department of Ophthalmology, Boston Children's Hospital, Boston, MA; Department of Ophthalmology, Harvard Medical School; Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA.

Purpose: To determine the frequency of receded near point of convergence (NPC) in patients with chronic concussion-related symptoms, and among those with receded NPC to enumerate the frequency of convergence insufficiency and other oculomotor disorders.

Study: Design: Retrospective cross-sectional study METHODS: Clinic charts were retrospectively reviewed for the prior 3.5 years to identify all patients <21 years old who were >28 days post-concussion, had chronic concussion-related symptoms, had normal visual acuity, and received a comprehensive sensorimotor examination. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.04.008DOI Listing

Retinal Vessel Phenotype in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy.

Am J Ophthalmol 2019 Apr 17. Epub 2019 Apr 17.

Department of ophthalmology, University Hospital of Grenoble-Alpes, France; Grenoble-Alpes University, HP2 Laboratory, INSERM U1042, Grenoble, France; Department of Ophthalmology, University Hospital of Grenoble-Alpes, Grenoble, France. Electronic address:

Purpose: The pathophysiology of non-arteritic AION (N-AION) is not completely understood. Studies of the retinal vasculature phenotype in patients with N-AION could help us to understand vascular abnormalities associated with the disease.

Design: Retrospective case series with matched controls. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.04.007DOI Listing

Influence Of Age, Sex And Generation On Physician Payments And Clinical Activity In Ontario, Canada: An Age-Period-Cohort Analysis.

Am J Ophthalmol 2019 Apr 17. Epub 2019 Apr 17.

Department of Ophthalmology and Visual Sciences, University of Toronto, 340 College Street, Suite 400, Toronto, Ontario, Canada M5T 3A9; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada M5T 3M7.

Purpose: To compare the effect of age, sex and generation on physician practice patterns in Ontario, Canada.

Design: Retrospective cohort study.

Methods: Physician and patient data from 1992-2013 were used to calculate yearly number of physicians, distinct patients seen, patient visits, government payments, physician age, sex, specialty and year of birth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193018
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http://dx.doi.org/10.1016/j.ajo.2019.04.006DOI Listing

Optical Coherence Tomography Angiography for Evaluation of Reperfusion following Pterygium Surgery.

Am J Ophthalmol 2019 Apr 5. Epub 2019 Apr 5.

Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore; Department of Cornea and External Eye Disease, Singapore National Eye Centre, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore. Electronic address:

Purpose: To describe the use of optical coherence tomography angiography (OCTA) to quantitatively monitor the conjunctival graft revascularization after pterygium excision and conjunctival autograft (CAG) transplantation.

Design: Prospective, interventional case series.

Methods: Ten patients undergoing pterygium excision and femtosecond laser-assisted CAG transplantation were included. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.04.003DOI Listing

Aqueous Humor Cytokines and Long-Term Response to Anti-Vascular Endothelial Growth Factor Therapy in Diabetic Macular Edema.

Am J Ophthalmol 2019 Apr 5. Epub 2019 Apr 5.

Department of Ophthalmology and Vision Sciences, University of Toronto, Canada; Department of Ophthalmology, St. Michael's Hospital, Canada. Electronic address:

Purpose: To determine the association of aqueous humor cytokine concentrations with long-term treatment response to anti-vascular endothelial growth factor (VEGF) agents in diabetic macular edema (DME).

Design: Retrospective case series.

Methods: Pooled data of aqueous humor cytokine concentrations collected at baseline and 2-month follow-up (2 injections) for treatment-naïve eyes with center-involving DME previously enrolled in a prospective study were reviewed. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.04.002DOI Listing
April 2019
2 Reads
3.871 Impact Factor

Classification of Regions of Nonperfusion on Ultra-widefield Fluorescein Angiography in patients with Diabetic Macular Edema.

Am J Ophthalmol 2019 Apr 5. Epub 2019 Apr 5.

Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, USA; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. Electronic address:

Purpose: To classify retinal nonperfusion regions (NPR) in patients with diabetic macular edema (DME) and assess the relationship with severity of DME.

Design: Prospective, observational case series.

Methods: Forty eyes of 29 patients with treatment-naïve center-involved macular edema secondary to diabetes mellitus were included (The DAVE study, NCT01552408) in this analysis. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.030DOI Listing

Glucose tolerance levels and circumpapillary retinal nerve fiber layer thickness in a general Japanese population: the Hisayama Study.

Am J Ophthalmol 2019 Apr 5. Epub 2019 Apr 5.

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Purpose: To investigate the relationship between glucose tolerance levels and the circumpapillary retinal nerve fiber layer thickness (cpRNFLT) in a general Japanese population.

Design: Population-based, cross-sectional study.

Methods: In 2012 and 2013, a total of 2,809 Japanese community-dwellers aged 40-79 years in the Hisayama Study underwent eye examinations including cpRNFLT measurement with spectral domain optical coherence tomography. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193014
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http://dx.doi.org/10.1016/j.ajo.2019.03.031DOI Listing
April 2019
2 Reads

Retinal vein occlusion is associated with low blood high-density lipoprotein cholesterol: a nationwide cohort study.

Am J Ophthalmol 2019 Apr 5. Epub 2019 Apr 5.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Purpose: To investigate association between the development of retinal vein occlusion (RVO) and blood high-density lipoprotein cholesterol (HDL-C).

Design: A retrospective, nationwide, population-based cohort study.

Methods Setting: Republic of Korea STUDY POPULATION: This study included 23,149,403 people aged 20 years or older who underwent the Korean National Health Screening Program examination between January 2009 and December 2012. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193015
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http://dx.doi.org/10.1016/j.ajo.2019.04.001DOI Listing
April 2019
8 Reads

Choroidal Vascular Changes in Arteritic and Non-arteritic Anterior Ischemic Optic Neuropathy.

Am J Ophthalmol 2019 Apr 4. Epub 2019 Apr 4.

Ophthalmology Unit, S.Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.

Purpose: To compare choroidal vascularity index (CVI) in patients with arteritic anterior ischemic optic neuropathy (A-AION), non-arteritic anterior ischemic optic neuropathy (NA-AION) and control subjects.

Design: Retrospective cross-sectional study.

Methods: This study was conducted at the Ophthalmology Unit of the S. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.028DOI Listing

Loss of Peak Vision in Retinal Vein Occlusion Patients Treated for Macular Edema.

Am J Ophthalmol 2019 Apr 4. Epub 2019 Apr 4.

The Wilmer Eye Institute, Johns Hopkins University, Baltimore MD. Electronic address:

Purpose: To evaluate long term visual and anatomic outcomes in patients with retinal vein occlusion (RVO) treated with anti-vascular endothelial growth factor (VEGF) agents DESIGN: Prospective, interventional case series PARTICIPANTS: Patients with central RVO (CRVO) or branch RVO (BRVO) METHODS: Number of anti-VEGF injections and improvement from baseline best-corrected visual acuity (BCVA) and central subfield thickness (CST) were prospectively recorded in 40 eyes of 39 CRVO patients and 50 eyes of 47 BRVO patients.

Results: Mean follow up was 58 months for BRVO and 78 months for CRVO. Within 6 months of last follow up, 58% of BRVO patients and 75% of CRVO patients required anti-VEGF injections to control edema. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.029DOI Listing
April 2019
3.871 Impact Factor

Retrospective Validation of the Postnatal Growth and Retinopathy of Prematurity (G-ROP) Criteria in a Japanese Cohort.

Am J Ophthalmol 2019 Apr 4. Epub 2019 Apr 4.

Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.

Purpose: We aimed to externally validate the performance of new screening criteria for retinopathy of prematurity (ROP) developed in the Postnatal Growth and Retinopathy of Prematurity (G-ROP) study among a Japanese cohort.

Design: Validation of screening criteria METHODS: We reviewed premature infants screened for ROP between September 2009 and May 2017 at a single institute. The G-ROP criteria, except hydrocephalus, were applied as a prediction model for infants with both a known outcome of ROP and serial measurements of weight gain. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.027DOI Listing

Remission Of Non-Infectious Anterior Scleritis: Incidence And Predictive Factors.

Am J Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.

Purpose: To assess how often non-infectious anterior scleritis remits and identify predictive factors.

Methods: Our retrospective cohort study at four ocular inflammation subspecialty centers collected data for each affected eye/patient at every visit from center inception (1978, 1978, 1984, 2005) until 2010. Remission was defined as inactivity of disease off all suppressive medications at all visits spanning at least three consecutive months or at all visits up to the last visit (to avoid censoring patients stopping follow-up after remission). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.024DOI Listing
April 2019
1 Read

Factors Predictive of Double Anterior Chamber Formation Following Deep Anterior Lamellar Keratoplasty.

Am J Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Ospedale Privato "Villa Igea", Department of Ophthalmology, Forlì, Italy; Istituto Internazionale per la Ricerca e Formazione in Oftalmologia (IRFO), Forlì, Italy; University of Ferrara, Department of Morphology, Surgery and Experimental Medicine, Ferrara, Italy. Electronic address:

Purpose: To identify risk factors predictive of postoperative double anterior chamber formation after deep anterior lamellar keratoplasty (DALK) DESIGN: Retrospective institutional cohort study METHODS: The study group included all consecutive eyes undergoing primary DALK between May 2015 and October 2018 at Villa Igea private hospital (Forli, Italy). The indications for surgery were categorized as 1) Keratoconus without scarring; 2) Keratoconus with scarring 3) Non-keratoconus without scarring; and 4) Non-keratoconus with scarring. Multivariate binary logistic regression analysis was performed, introducing, as independent variables, those that reached a significance level of less than 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193013
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http://dx.doi.org/10.1016/j.ajo.2019.03.026DOI Listing
April 2019
2 Reads

Microbial Keratitis in Taiwan: A 20-Year update.

Am J Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Purpose: To investigate the demographics, risk factors, microbiology and resistance pattern at a tertiary hospital and to detect the shifting trend over two decades.

Design: A retrospective observational case series.

Methods: We reviewed all records of patients with microbial keratitis (MK) that were hospitalized in National Taiwan University Hospital between 2007 and 2016. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.023DOI Listing
April 2019
1 Read

Focal and diffuse chronic central serous chorioretinopathy treated with half-dose photodynamic therapy or subthreshold micropulse laser.

Am J Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; Amsterdam UMC, University of Amsterdam, Department of Ophthalmology, Meibergdreef 9, Amsterdam, Netherlands. Electronic address:

Purpose: To compare the outcome between high-density subthreshold micropulse laser (HSML) treatment and half-dose photodynamic therapy (PDT) in chronic central serous chorioretinopathy (cCSC) patients, subdivided based on either focal or diffuse leakage on fluorescein angiography (FA). Design; Retrospective analysis of multicenter randomized controlled trial data METHODS: Patients were treated with either half-dose PDT or HSML (both ICGA-guided) and categorized in 2 groups, based on focal or diffuse leakage on FA. Clinical outcomes were evaluated at baseline and during follow-up. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.025DOI Listing
April 2019
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Comparison of endothelial keratoplasty techniques in patients with prior glaucoma surgery - a case-matched study.

Am J Ophthalmol 2019 Mar 29. Epub 2019 Mar 29.

Stein Eye Institute, David Geffen School of Medicine, University of California - Los Angeles: Los Angeles, CA 300 Stein Plaza Los Angeles, CA 90095 United States. Electronic address:

Purpose: To evaluate the outcomes of Descemet membrane endothelial keratoplasty (DMEK) and Descemet's stripping endothelial keratoplasty (DSEK) in eyes with prior glaucoma surgery. Design; Case-matched retrospective comparative case series.

Methods: Setting / Study Population: Forty-six DMEK procedures were matched with 46 DSEK procedures at a single institution. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.020DOI Listing
March 2019
1 Read

Auckland Cataract Study III: Refining Preoperative Assessment With Cataract Risk Stratification to Reduce Intraoperative Complications.

Am J Ophthalmol 2019 Apr 22;200:253-254. Epub 2019 Feb 22.

New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1016/j.ajo.2019.01.013DOI Listing
April 2019
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Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion.

Authors:
Sandra M Brown

Am J Ophthalmol 2019 Apr 22;200:252. Epub 2019 Feb 22.

Concord, North Carolina.

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http://dx.doi.org/10.1016/j.ajo.2019.01.020DOI Listing

Diabetes Alone Does Not Impair Recovery From Uneventful Cataract Surgery.

Am J Ophthalmol 2019 Apr 15;200:224-225. Epub 2019 Feb 15.

Wroclaw, Poland.

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http://dx.doi.org/10.1016/j.ajo.2018.11.026DOI Listing

Time requirements of paper-based clinical workflows and after-hours documentation in a multi-specialty academic ophthalmology practice.

Am J Ophthalmol 2019 Mar 22. Epub 2019 Mar 22.

UCSD Health Department of Biomedical Informatics, La Jolla, CA; UCSD Department of Medicine, La Jolla, CA; Veterans Administration San Diego Healthcare System Division of Health Services Research and Development, La Jolla, CA.

Purpose: To assess time requirements for patient encounters and estimate after-hours demands of paper-based clinical workflows in ophthalmology.

Design: Time-and-motion study with a structured survey METHODS:• SETTING: : Single academic ophthalmology department.

Participants And Observation Procedures: Convenience sample of seven attending ophthalmologists from six subspecialties observed during 414 patient encounters for the time-motion analysis and twelve attending ophthalmologists for the survey. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.014DOI Listing

Misery perfusion, diffusive oxygen shunting and interarterial watershed infarction underlie oxygenation-based hypoperfusion maculopathy.

Authors:
David McLeod

Am J Ophthalmol 2019 Mar 21. Epub 2019 Mar 21.

Academic Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester University NHS Foundation Trust, Oxford Road, Manchester M13 9WL, UK; and Centre for Ophthalmology and Vision Research, Institute of Human Development, University of Manchester, Manchester, United Kingdom. Electronic address:

Purpose: To describe and explain the entire range of ischemic macular damage that follows panretinal hypoperfusion from central retinal artery or vein occlusion.

Design: Perspective article.

Methods: Correlation of the fundoscopic, fluorescein angiographic, oximetric and optical coherence tomographic (OCT) features developing within the posterior inner retina following incremental reductions in arterio-venous perfusion pressure across the retinal circulation. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.015DOI Listing

Telemedicine in the management of exudative age-related macular degeneration within an integrated healthcare system.

Am J Ophthalmol 2019 Mar 21. Epub 2019 Mar 21.

Mayo Clinic Department of Ophthalmology, Rochester, MN. Electronic address:

Purpose: To investigate the outcomes of patients with exudative age-related macular degeneration (AMD) treated with intravitreal anti-vascular endothelial growth factors (VEGF) using a telemedicine system.

Design: Interventional case series.

Methods: We examined all patients with exudative AMD who were receiving intravitreal anti-VEGF injections from September 1, 2015 through August 31, 2017 using electronic consults at a single academic center and health system. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.021DOI Listing
March 2019
1 Read
3.871 Impact Factor

Refractive error has minimal influence on the risk of age-related macular degeneration: A Mendelian randomization study.

Am J Ophthalmol 2019 Mar 21. Epub 2019 Mar 21.

School of Optometry & Vision Sciences, Cardiff University, Cardiff, Wales, UK.

Purpose: To test the hypothesis that refractive errors such as myopia and hyperopia cause an increased risk of age-related macular degeneration (AMD), and to quantify the degree of risk.

Design: Two-sample Mendelian randomization analysis of data from a genome-wide association study PARTICIPANTS: As instrumental variables for refractive error, 126 genome-wide significant genetic; variants identified by the CREAM consortium and 23andMe Inc. were chosen. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.018DOI Listing

Cost-effectiveness Analysis of Multifocal Intraocular Lenses Compared to Monofocal Intraocular Lenses in Cataract Surgery.

Am J Ophthalmol 2019 Mar 21. Epub 2019 Mar 21.

Shiley Eye Institute, University of California, San Diego, La Jolla, California, USA. Electronic address:

Purpose: To determine the cost-effectiveness of multifocal intraocular lenses (IOLs) compared to monofocal IOLs from a societal and healthcare sector perspective.

Design: Cost-effectiveness analysis.

Methods: We constructed a Markov model where we simulated patients received either multifocal or monofocal IOLs during cataract surgery. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.019DOI Listing

The auroKPro versus the Boston type I Keratoprosthesis: 5-year Clinical Outcomes in 134 Cases of Bilateral Corneal Blindness.

Am J Ophthalmol 2019 Mar 21. Epub 2019 Mar 21.

Tej Kohli Cornea Institute, L V Prasad Eye Institute, Hyderabad 500034, Telangana, India.

Purpose: To compare the clinical outcomes of Boston type I keratoprosthesis (Boston Kpro) with its low-cost version, the auroKPro.

Design: Retrospective comparative Case series.

Methods: This study included 134 eyes of 130 patients with severe bilateral corneal blindness but with wet ocular surfaces. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193012
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http://dx.doi.org/10.1016/j.ajo.2019.03.016DOI Listing
March 2019
3 Reads

Are Descemet membrane ruptures the root cause of corneal hydrops in keratoconic eyes?

Am J Ophthalmol 2019 Mar 21. Epub 2019 Mar 21.

Netherlands Institute for Innovative Ocular Surgery - USA (NIIOS-USA), San Diego, California, USA; Netherlands Institute for Innovative Ocular Surgery (NIIOS), Rotterdam, The Netherlands; Melles Cornea Clinic, Rotterdam, The Netherlands; Amnitrans EyeBank Rotterdam, Rotterdam, The Netherlands. Electronic address:

Purpose: To challenge the current consensus on the mechanism for corneal hydrops in eyes with keratoconus (KC).

Design: Retrospective, interventional case series.

Methods: Sixteen eyes of 10 patients with comorbid KC and Fuchs endothelial corneal dystrophy (FECD) underwent uncomplicated Descemet membrane endothelial keratoplasty (DMEK), and 5 eyes of 5 patients with KC alone underwent Bowman layer (BL) transplantation, complicated by inadvertent perforation of the posterior corneal stroma and Descemet membrane (DM). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.017DOI Listing

Shortening of Interpupillary Distance after Instillation of Topical Prostaglandin Analogue Eye Drops.

Am J Ophthalmol 2019 Mar 19. Epub 2019 Mar 19.

Community Health Care Organization Tokyo Shinjuku Medical Center, 5-1 Tsukudocho, Shinjuku-ku, Tokyo 162-8543, Japan.

Purpose: To investigate changes in the interpupillary distance (IPD) after continual instillation of topical prostaglandin analogues (PGAs) in glaucoma patients as an objective indicator of prostaglandin-associated periorbitopathy (PAP).

Design: Retrospective, comparative case series.

Methods: SETTING: Institutional. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.013DOI Listing

Effect of Topical Hypotensive Medications for Preventing Intraocular Pressure Increase after Cataract Surgery in Eyes with Glaucoma.

Am J Ophthalmol 2019 Mar 19. Epub 2019 Mar 19.

Hayashi Eye Hospital, Fukuoka, Japan.

Purpose: To compare the effects of a topical intraocular pressure (IOP)-lowering medication for preventing an IOP increase after cataract surgery in eyes with glaucoma.

Design: Randomized clinical study.

Methods: One hundred sixty-five eyes of 165 patients with primary open-angle glaucoma or pseudoexfoliation glaucoma scheduled for phacoemulsification were randomly assigned to one of three groups to receive each medication immediately postoperatively: 1) prostaglandin F2α analogue (travoprost), 2) β-blocker (timolol maleate), or 3) carbonic anhydrase inhibitor (brinzolamide). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.012DOI Listing

Ultra-widefield optical coherence tomographic imaging of posterior vitreous in eyes with high myopia.

Am J Ophthalmol 2019 Mar 19. Epub 2019 Mar 19.

Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University (TMDU) Graduate School of Medical and Dental Sciences, Tokyo, Japan. Electronic address:

Purpose: To investigate the morphological changes of posterior vitreous in highly myopic (HM) eyes of patients older than 50 years.

Design: Retrospective, observational case series.

Methods: Ultra-widefield swept-source OCT (UWF-OCT) examinations were performed on 768 eyes of 448 HM patients (50- to 89-years) and 54 eyes of 52 non-HM subjects with scan width of 23 mm and depth of 5 mm. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.011DOI Listing

Visual impairment in fungal versus bacterial corneal ulcers four years after successful antimicrobial treatment.

Am J Ophthalmol 2019 Mar 19. Epub 2019 Mar 19.

Department of Ophthalmology; Francis I. Proctor Foundation. Electronic address:

Purpose: To compare longitudinal visual acuity outcomes of fungal corneal ulcers with those of bacterial ulcers.

Design: Prospective cohort study SETTING: Tertiary eye hospital in South India STUDY POPULATION: 100 individuals who had been diagnosed four years prior with either fungal or bacterial keratitis and had been enrolled in one of two concurrent randomized trials, out of 152 consecutive participants eligible for the study.

Exposure: Causative organism of infectious keratitis (bacteria versus fungus) MAIN OUTCOME MEASURES: Presenting visual acuity, best spectacle corrected visual acuity (BSCVA), and hard contact lens-corrected visual acuity (CLVA). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.010DOI Listing

Motivations and Decision-Making Processes of Men with X-linked Retinoschisis Considering Participation in an Ocular Gene Therapy Trial.

Am J Ophthalmol 2019 Mar 15. Epub 2019 Mar 15.

Director, National Eye Institute, National Institutes of Health, 31 Center Drive MSC 2510, Bethesda, MD 20892, USA.

Purpose: To describe the motivations, expectations, and other factors men with X-linked retinoschisis (XLRS) consider when making decisions to participate in an early-phase ocular gene therapy clinical trial.

Design: Qualitative interview study METHODS: Men with XLRS who were considering participation in a Phase I/IIa ocular gene therapy clinical trial at the National Eye Institute were eligible for this study. Trial participants (n=9) were interviewed prior to receiving the gene transfer and then 3 and 12 months later. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193010
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http://dx.doi.org/10.1016/j.ajo.2019.03.009DOI Listing
March 2019
7 Reads

Demodex mite infestation and its associations with tear film and ocular surface parameters in patients with ocular discomfort.

Am J Ophthalmol 2019 Mar 15. Epub 2019 Mar 15.

Department of Ophthalmology, Medical University of Graz, Austria.

Purpose: The presence of Demodex species can be associated with blepharitis. Their pathogenic potential in Meibomian Gland Dysfunction (MGD) was discussed. The purpose of this study was to determine the prevalence of Demodex mites in eyelashes of Austrian patients with ocular discomfort and to evaluate associated changes of the lid margins and meibomian glands. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.007DOI Listing
March 2019
1 Read

Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification.

Am J Ophthalmol 2019 Mar 15. Epub 2019 Mar 15.

New England Eye Center, Tufts Medical Center, Boston, Massachusetts, USA. Electronic address:

Purpose: Binarization is a critical technique in OCTA image analysis, but there is no consistency in the method used in published OCTA studies. This study assessed whether differences in OCTA binarization and brightness/contrast adjustments affect quantification metrics.

Design: Prospective cross-sectional validity study METHODS: This was a single-center study examining 21 eyes of 11 healthy individuals. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.008DOI Listing

Association of Macular and Circumpapillary Microvasculature with Visual Field Sensitivity in Advanced Glaucoma.

Am J Ophthalmol 2019 Mar 13. Epub 2019 Mar 13.

Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, and Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States. Electronic address:

Purpose: To evaluate the association between optical coherence tomography angiography (OCTA) macular and circumpapillary vessel density and visual field mean deviation (MD) in advanced primary open angle glaucoma (POAG).

Design: Cross-sectional study.

Methods: Macula (superficial layer) and optic nerve head [ONH, with (capillary density :CD) and without (vessel density: VD) automated removal of large vessels] OCTA of 34 eyes (34 patients, MD < -10 dB) were investigated as macula whole image VD (wiVD), parafoveal VD (pfVD), ONH wiVD, wiCD, circumpapillary VD (cpVD), and cpCD. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.004DOI Listing
March 2019
3.871 Impact Factor

Anti-VEGF Therapy for Diabetic Retinopathy: Consequences of Inadvertent Treatment Interruptions.

Am J Ophthalmol 2019 Mar 13. Epub 2019 Mar 13.

University of Michigan, Kellogg Eye Center, Department of Ophthalmology and Visual Sciences.

Purpose: To illustrate that patients with diabetic retinopathy who are treated exclusively with anti-VEGF therapy and have an interruption in treatment may experience marked progression of disease with potentially devastating visual consequences.

Design: Retrospective, multicenter, case series METHODS: Retrospective review of patients treated exclusively with anti-VEGF therapy for proliferative (PDR) or non-proliferative diabetic retinopathy (NPDR), with or without diabetic macular edema (DME), and temporarily lost to follow-up. Baseline disease characteristics, cause and duration of the treatment interruption, and resulting disease progression, complications, and outcomes were assessed. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.005DOI Listing
March 2019
1 Read

Three-year follow-up of Phase 1 and 2a rAAV.sFLT-1 subretinal gene therapy trials for exudative age related macular degeneration.

Am J Ophthalmol 2019 Mar 13. Epub 2019 Mar 13.

Lions Eye Institute, Nedlands, WA, Australia; Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, WA, Australia; Sir Charles Gairdner Hospital, Nedlands, WA, Australia.

Purpose: To assess the safety and the 3-year results of combined Phase 1 and 2a randomised controlled trials of rAAV.sFLT-1 gene therapy (GT) for wet-AMD.

Design: Phase 1/2a clinical trial METHODS: Patients were prospectively randomised into control (n=13) and GT (n=24) groups. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.006DOI Listing
March 2019
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Predictors of Neovascular Glaucoma in Central Retinal Vein Occlusion.

Am J Ophthalmol 2019 Mar 9. Epub 2019 Mar 9.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL.

Purpose: To determine the risk factors for development of neovascular glaucoma (NVG) in patients after an acute central retinal vein occlusion (CRVO).

Design: Retrospective cohort study METHODS: Review of medical records of 646 patients with a diagnosis of CRVO between 2013 to 2017 at the Bascom Palmer Eye Institute.

Inclusion Criteria: 1) CRVO onset to presentation <90 days; 2) Absence of anterior segment neovascularization on presentation; 3) No intravitreal anti-VEGF injection before presentation. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.038DOI Listing

Five-year real-world outcomes of occult and classic choroidal neovascularization: data from the Fight Retinal Blindness! Project.

Am J Ophthalmol 2019 Mar 9. Epub 2019 Mar 9.

The University of Sydney, Save Sight Institute, Discipline of Ophthalmology, Sydney Medical School, Sydney, NSW, Australia.

Purpose: To compare 5-year real-world outcomes of eyes with classic and occult choroidal neovascularization (CNV) treated with anti-Vascular Endothelial Growth Factor (anti-VEGF) injections.

Design: Retrospective analysis from a prospectively designed observational database.

Methods: Treatment-naïve eyes diagnosed with occult, minimally or predominantly classic CNV that commenced anti-VEGF treatment between Jan-2007 and Dec-2012 were identified from a registry of neovascular age related macular degeneration (nAMD) treatment outcomes. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.001DOI Listing

Once-Daily Netarsudil vs Twice-Daily Timolol in Patients with Elevated Intraocular Pressure, the Randomized Phase 3 ROCKET-4 Study.

Am J Ophthalmol 2019 Mar 9. Epub 2019 Mar 9.

Aerie Pharmaceuticals, Inc., Irvine, California; Bedminster, New Jersey; and Durham, North Carolina, USA.

Purpose: To compare the intraocular pressure (IOP)-lowering efficacy and safety of netarsudil once-daily (QD) and timolol twice-daily (BID).

Design: Double-masked, randomized, phase 3, non-inferiority study.

Methods: Patients with open-angle glaucoma or ocular hypertension (unmedicated baseline IOP >20 to <30 mmHg at 8:00 AM) were randomized to netarsudil ophthalmic solution 0. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.002DOI Listing
March 2019
2 Reads
3.871 Impact Factor

Meibomian Gland Dysfunction and Dry Eye are Similar, but Different based on a Population-Based Study (Hirado-Takushima Study) in Japan.

Am J Ophthalmol 2019 Mar 6. Epub 2019 Mar 6.

Lid and Meibomian Gland Working Group (LIME), Japan; Department of Ophthalmology Toho University Oomori Hospital, Tokyo, Japan.

Purpose: To evaluate the prevalence and risk factors of and the relation between meibomian gland dysfunction (MGD) and dry eye (DE) in Japan.

Design: A population-based cross-sectional study.

Methods: Participants filled in questionnaires regarding ocular symptoms, systemic diseases, and lifestyle factors. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.024DOI Listing
March 2019
1 Read

Ocular Exposures Reported to Poison Control Centers from 2011 to 2015.

Am J Ophthalmol 2019 Mar 6. Epub 2019 Mar 6.

Division of Care Transformation; Banner - University Medical Center Phoenix.

Purpose: Identify and characterize the ocular exposures reported to poison control centers over a five-year period from 2011 - 2015 in the United States.

Design: Pooled cross-sectional study SUBJECTS: Callers to poison control centers METHODS: We retrospectively analyzed data from 477,274 calls for ocular exposure to the National Poison Data System.

Main Outcomes Measures: Major medical outcomes, reason for exposure, location of exposure, and causative xenobiotic were evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193009
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http://dx.doi.org/10.1016/j.ajo.2019.02.037DOI Listing
March 2019
2 Reads

The LXXV Edward Jackson Memorial Lecture: Lessons Learned from Avastin and OCT: The Great, The Good, The Bad, and The Ugly.

Am J Ophthalmol 2019 Mar 6. Epub 2019 Mar 6.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA. Electronic address:

Purpose: To describe the synergistic benefits and cost-savings from the use of optical coherence tomography (OCT) and vascular endothelial growth factor (VEGF) inhibitors, particularly intravitreal bevacizumab, in the treatment of exudative age-related macular degeneration (AMD) DESIGN: Retrospective literature review and personal perspective.

Methods: Retrospective literature review and personal perspective.

Results: The introduction of the first clinically useful OCT instrument coincided with early phase clinical trials of a drug that would become known as ranibizumab. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.036DOI Listing

A Deep Learning System for Automated Angle-Closure Detection in Anterior Segment Optical Coherence Tomography Images.

Am J Ophthalmol 2019 Mar 5. Epub 2019 Mar 5.

Singapore Eye Research Institute, Singapore National Eye Center, Singapore; EYE-ACP, Duke-NUS Medical School, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Purpose: Anterior segment optical coherence tomography (AS-OCT) provides an objective imaging modality for visually identifying anterior segment structures. An automated detection system could assist ophthalmologists in interpreting AS-OCT images for presence of angle closure.

Design: Development of an artificial intelligence automated detection system for the presence of angle closure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193008
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http://dx.doi.org/10.1016/j.ajo.2019.02.028DOI Listing
March 2019
12 Reads
3.871 Impact Factor

Characterization and Management of Late Postoperative Capsular Block Syndrome following Phacoemulsification or Phacovitrectomy.

Am J Ophthalmol 2019 Mar 5. Epub 2019 Mar 5.

Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China. Electronic address:

Purpose: To compare the clinical characteristics of eyes affected by late postoperative capsular block syndrome (CBS) after routine phacoemulsification or phacovitrectomy, and to demonstrate the outcomes of Nd:YAG capsulotomy and posterior continuous curvilinear capsulorrhexis (PCCC) in the treatment of CBS.

Design: Retrospective interventional case series.

Methods: Twenty-eight patients with late postoperative CBS, comprising 13 eyes after phacoemulsification (Group A) and 15 eyes after phacovitrectomy (Group B), were analyzed. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.035DOI Listing

Prospective study of the diagnostic accuracy of the in vivo laser scanning confocal microscope for ocular demodicosis.

Am J Ophthalmol 2019 Mar 5. Epub 2019 Mar 5.

Dept of ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan. 430060, Hubei Province, China.

Purpose: To determine the diagnostic accuracy of in vivo confocal microscopy (IVCM) for ocular demodicosis DESIGN: Reliability and Validity analysis.

Methods: Setting: Single-center study.

Patients: Consecutive patients presenting to Zhongnan Hospital of Wuhan University, Hubei, China, between February 2017 and February 2018 with blepharitis. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.026DOI Listing

Pterygium Prevalence and Its Associations in a Russian Population: The Ural Eye and Medical Study.

Am J Ophthalmol 2019 Mar 5. Epub 2019 Mar 5.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.

Purpose: To assess the prevalence of pterygia and its associations in a population of Russia.

Design: Population-based cross-sectional study METHODS: The Ural Eye and Medical Study was performed in a rural and urban area in Ufa/Bashkortostan 1300 km East of Moscow. Out of 7328 eligible individuals aged 40+ years, 5,899 (80. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.031DOI Listing
March 2019
2 Reads

Intraocular Pressure and Its Associations in a Russian population: The Ural Eye and Medical Study.

Am J Ophthalmol 2019 Mar 5. Epub 2019 Mar 5.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.

Purpose: To assess the normal distribution of intraocular pressure (IOP) and its associations with ocular, medical, and socioeconomic factors in a Russian population.

Design: Population-based cross-sectional study METHODS: The Ural Eye and Medical Study conducted in a rural and urban area in Ufa/Bashkortostan included 5,899 (80.5%) participants out of 7328 eligible individuals aged 40+ years. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.030DOI Listing
March 2019
2 Reads