25,468 results match your criteria American journal of ophthalmology[Journal]


Detection of longitudinal visual field progression in glaucoma using machine learning.

Am J Ophthalmol 2018 Jun 16. Epub 2018 Jun 16.

Graduate School of Information Science and Technology, The University of Tokyo, Japan.

Purpose: Global indices of standard automated perimerty are insensitive to localized losses, while point-wise indices are sensitive but highly variable. Region-wise indices sit in between. This study introduces a machine-learning-based index for glaucoma progression detection that outperforms global, region-wise, and point-wise indices. Read More

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Cuban Epidemic optic neuropathy (1991-1993) And josé saramago's novel blindness (1995).

Am J Ophthalmol 2018 Jun 12. Epub 2018 Jun 12.

The Department of English, Washington University.

Purpose: This article reviews the history of Cuban Epidemic Optic Neuropathy (1991-1993), which caused visual loss, peripheral neuralgias, and other neurological symptoms in over 50,000 persons, an incidence of almost 0.5% of the entire population. The clinical findings, etiology, and treatment are described. Read More

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Cataract Surgical Coverage And Visual Acuity Outcomes In Rural China In 2014 And Comparisons With The 2006 China Nine-Province Survey.

Am J Ophthalmol 2018 Jun 12. Epub 2018 Jun 12.

Rehabilitation Administration Department, National Institute of Hospital Administration, Beijing, China.

Purpose: Estimate surgical coverage of cataract-related vision impairment and blindness and visual acuity outcomes in operated eyes in rural China in 2014 with comparisons with the 2006 Nine-Province Survey.

Design: Population-based, cross-sectional study.

Methods: Geographical cluster sampling was used in randomly selecting residents from a rural county or semi-rural district within 9 provinces: Beijing, Jiangsu, Guangdong, Heilongjiang, Jiangxi, Hebei, Ningxia, Chongqing and Yunnan. Read More

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Five year postoperative outcomes of Bilateral Aphakia and Pseudophakia in children upto 2 years of age: a Randomized Clinical Trial.

Am J Ophthalmol 2018 Jun 12. Epub 2018 Jun 12.

Iladevi Cataract & IOL Research Centre, Ahmedabad, India.

Purpose: Comparative evaluation of complications and visual outcomes following bilateral congenital cataract surgery in children upto 2 years of age with and without primary intraocular lens (IOL) implantation at 5 years follow-up DESIGN: Randomized, controlled, clinical trial METHODS: 60 children (120 eyes) upto 2 years of age undergoing bilateral congenital cataract surgery randomized to: group 1, primary aphakia (n=30) or group 2,primary IOL implantation (n=30). Single surgeon performed surgeries with identical surgical technique. All patients were followed up regularly until 5 years postoperatively. Read More

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Material Analysis and Optical Quality Assessment of Opacified Hydrophilic Acrylic Intraocular Lenses after Pars Plana Vitrectomy.

Am J Ophthalmol 2018 Jun 8. Epub 2018 Jun 8.

The David J. Apple International Laboratory for Ocular Pathology, Department of Ophthalmology, University of Heidelberg, Germany.

Purpose: Explanted hydrophilic intraocular lenses (IOLs) with clinically significant opacification after pars plana vitrectomy (PPV) were assessed for material change and optical quality, in an in-vitro laboratory study.

Design: Retrospective observational case series.

Methods: 10 opacified IOLs after PPV with intraocular gas injection were analyzed in a laboratory setting. Read More

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Corneal Ectasia in Steven Johnson Syndrome: A Sequelae of Chronic Disease.

Am J Ophthalmol 2018 Jun 8. Epub 2018 Jun 8.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Purpose: To describe corneal ectasia in cases of chronic Steven Johnson Syndrome (SJS) DESIGN: Prospective observational study METHOD SETTING: Institutional PATIENT: Fifteen consecutive cases of chronic SJS MAIN OUTCOME MEASURES: Best corrected distance visual acuity (BCDVA), Kmax, anterior elevation, posterior elevation, thinnest pachymetry and Sotozono severity score RESULTS: 30 eyes of fifteen patients were included. Corneal tomography using Scheimpflug technology (Pentacam-HR, Oculus GmbH) was performed. Nine eyes were excluded due to poor quality scans. Read More

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Pathologic Markers Determining Prognosis in Patients with Treated or Healing Giant Cell Arteritis.

Am J Ophthalmol 2018 Jun 8. Epub 2018 Jun 8.

Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA Blanton Eye Institute, Department of Ophthalmology, Houston Methodist Hospital, Houston, TX, USA Departments of Pathology and Laboratory Medicine and Ophthalmology, Weill Cornell Medical College, New York, NY, USA Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA, Department of Pathology & Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Purpose: To provide quantitative evidence linking the Cluster of Differentiation-68 (CD68)+ macrophage-marker found on temporal artery biopsies (TABs) with disease prognosis.

Design: Retrospective, cross-sectional study METHODS: We examined 42 consecutive patients who had undergone unilateral TABs at a single hospital in 2015. Clinical data, laboratory data, and histopathologic features of TABs were recorded. Read More

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June 2018
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Inner nuclear layer thickness, a biomarker of metamorphopsia in epiretinal membrane, correlates with tangential retinal displacement.

Am J Ophthalmol 2018 Jun 8. Epub 2018 Jun 8.

Department of Ophthalmology, Teikyo University School of Medicine, University Hospital Mizonokuchi, Kanagawa, Japan.

Purpose: To examine correlations of inner nuclear layer (INL) thickness with metamorphosia and tangential retinal displacement in epiretinal membrane (ERM).

Design: Retrospective, consecutive, interventional case series.

Methods: SETTING: Institutional study PATIENT POPULATION: Fifty eyes of 50 patients undergoing epiretinal membrane surgery OBSERVATION PROCEDURES: M-CHARTS were used to measure metamorphopsia. Read More

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Longitudinal Changes of Fixation Location and Stability within 12 Months in Stargardt Disease: ProgStar Report No. 12.

Am J Ophthalmol 2018 Jun 8. Epub 2018 Jun 8.

Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA; Institute of Molecular and Clinical Ophthalmology Basel (IOB), Switzerland; Department of Ophthalmology, University of Basel, Switzerland. Electronic address:

Purpose: To investigate the natural history of Stargardt disease (STGD1) using fixation location and fixation stability.

Design: Multicenter, international, prospective cohort study.

Methods: Fixation testing was performed using the Nidek MP-1 microperimeter as part of the prospective, multicenter, natural history study on the Progression of Stargardt disease (ProgStar). Read More

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Ocular Adnexal Amyloidosis: A Mass Spectrometric Analysis.

Am J Ophthalmol 2018 Jun 8. Epub 2018 Jun 8.

Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195. Electronic address:

Purpose: Ocular adnexal amyloidosis may represent localized manifestation of an underlying systemic process. Accurate identification of the amyloid fibrils can guide the systemic work up and treatment. The aim of this study was to characterize subtypes of ocular adnexal amyloidosis using immunohistochemistry and mass spectrometric analysis and to correlate with ocular involvement and systemic association. Read More

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Topographic Macular Microvascular Changes and Correlation with Visual Loss in Chronic Leber's Hereditary Optic Neuropathy.

Am J Ophthalmol 2018 Jun 6. Epub 2018 Jun 6.

Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, USA; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Purpose: To study the macular microvascular networks in patients affected by chronic Leber's hereditary optic neuropathy (LHON) using optical coherence tomography angiography (OCTA), and to quantify these changes in different macular sectors.

Design: Prospective cross-sectional study.

Methods: Patients with a clinical and molecularly confirmed diagnosis of LHON (affected patients in the chronic stage) were enrolled from the neuro-ophthalmology clinic at the Doheny-UCLA. Read More

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The treat-and-extend injection regimen versus alternate dosing strategies in age-related macular degeneration: a systematic review and meta-analysis.

Am J Ophthalmol 2018 Jun 6. Epub 2018 Jun 6.

Royal Victorian Eye and Ear Hospital, Melbourne Australia; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital; Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne Australia.

Purpose: To assess outcomes of the treat-and-extend (T&E) injection regimen for neovascular age related macular degeneration (AMD) as compared to either a monthly or a pro-re-nata (PRN) treatment strategy.

Design: Systematic review and meta-analysis METHODS: Studies that compared the T&E regimen with either monthly or PRN dosing for treatment-naïve AMD were included. Trial eligibility, data extraction and risk of bias were assessed according to Cochrane review methods. Read More

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Is Corneal Arcus Independently Associated with Incident Cardiovascular Disease in Asians?

Authors:
Osama M Mustafa

Am J Ophthalmol 2018 Jun 5. Epub 2018 Jun 5.

Baltimore, Maryland, USA.

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June 2018
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Histologic Analysis of Trabecular Meshwork Obtained from Kahook Dual Blade Goniotomy.

Am J Ophthalmol 2018 Jun 5. Epub 2018 Jun 5.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine; Miami Veterans Affairs Healthcare System. Electronic address:

Purpose: To determine whether there are identifiable, reproducible findings in the trabecular meshwork (TM) of patients with primary open-angle glaucoma (POAG) who underwent Kahook dual blade (KDB) goniotomy.

Design: Non-comparative retrospective case series.

Methods: Tertiary academic referral center, Veterans Affairs Medical Center. Read More

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Features of the Choroidal Microvasculature in Peripapillary Atrophy are Associated with Visual Field Damage in Myopic Patients.

Am J Ophthalmol 2018 Jun 5. Epub 2018 Jun 5.

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Electronic address:

Purpose: Optical coherence tomography angiography (OCT-A) was used to investigate the features of choroidal microcirculation within the β-zone peripapillary atrophy (PPA) and its association with visual field (VF) defects in myopic patients.

Design: A cross-sectional study.

Methods: Participants: Eighty-four myopic patients with a unilateral glaucomatous VF defect. Read More

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What We Have Learned From the Ocular Hypertension Treatment Study.

Am J Ophthalmol 2018 May 31. Epub 2018 May 31.

St. Louis, Missouri.

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Angiographic signatures of the predominant form of familial transthyretin amyloidosis (Val30Met mutation).

Am J Ophthalmol 2018 May 30. Epub 2018 May 30.

Department of Ophthalmology, Bicêtre Hospital, Assistance Publique - Hôpitaux de Paris, DHU Vision & Handicaps, Paris-Sud University, French Reference Center for familial transthyretin amyloidosis (NNERF), French Reference Center for rare Ophthalmologic diseases (OPHTARA), Le Kremlin-Bicêtre, France. Electronic address:

Purpose: To describe abnormalities in choroidal and retinal vasculature associated with Val30Met familial transthyretin amyloidosis (V30M-FTA) using fluorescein and indocyanine green (ICG) angiography.

Design: Prospective, cross-sectional study.

Methods: This study was conducted at the French National Reference Center for FTA. Read More

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Microstructure of Parapapillary Atrophy Is Associated with Parapapillary Microvasculature in Myopic Eyes.

Am J Ophthalmol 2018 May 30. Epub 2018 May 30.

Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, Gwangju, South Korea; Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, South Korea. Electronic address:

Purpose: To evaluate the clinical characteristics of β-PPA in myopic eyes and determine whether the microstructure of β-PPA is associated with parapapillary microvasculature by using optical coherence tomography (OCT) angiography.

Design: Cross-sectional study METHODS: This study included 80 subjects with myopia with β-PPA. Spherical equivalent (SE) refractive error, axial length, horizontal tilt angle, and the width of β-PPA were evaluated. Read More

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Boston type I Keratoprosthesis: Antibacterial Resistance and Microbiota Evaluation of Soft Contact Lenses.

Am J Ophthalmol 2018 May 29. Epub 2018 May 29.

Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of Sao Paulo (EPM-UNIFESP), Sao Paulo, Brazil.

Purpose: To evaluate microbiota colonizing soft contact lenses (CL) in eyes with Boston type I keratoprosthesis (BKPro), and determine the prevalence of resistance to fourth-generation fluoroquinolone (FQ).

Design: Prospective, observational study.

Subjects: Patients with BKPro using CL as routine who were in postoperative follow-up in the department of ophthalmology from Federal University of Sao Paulo, and volunteered to participate in the study. Read More

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Breastfeeding and maternal age-related cataract.

Am J Ophthalmol 2018 May 25. Epub 2018 May 25.

Department of Health Convergence, Ewha Womans University, Seoul, Republic of Korea. Electronic address:

Purpose: No studies addressed the influence of breastfeeding on cataract formation. The objectives of this study was to address the relationship between breastfeeding and maternal age-related cataract.

Design: A nationwide cross-sectional study. Read More

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Characteristics of Neovascularization in Early Stages of Proliferative Diabetic Retinopathy by Optical Coherence Tomography Angiography.

Am J Ophthalmol 2018 May 25. Epub 2018 May 25.

School of Optometry and Ophthalmology, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China;. Electronic address:

Purpose: To classify retinal neovascularization in untreated early stages of proliferative diabetic retinopathy (PDR) based on optical coherence tomography angiography (OCTA).

Design: A cross-sectional study.

Methods: Thirty-five eyes were included. Read More

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Outcomes of cataract surgery in patients with exudative age-related macular degeneration and macular fluid.

Am J Ophthalmol 2018 May 23. Epub 2018 May 23.

Mayo Clinic Department of Ophthalmology, Rochester, MN. Electronic address:

Purpose: The purpose of this study was to investigate whether having macular fluid on the OCT prior to cataract surgery adversely affected vision or anatomic outcomes after cataract surgery in patients with exudative AMD.

Design: Retrospective, cohort study.

Methods: We examined all patients who underwent cataract surgery and were receiving intravitreal anti-VEGF injections from January 1, 2012 through December 31, 2016. Read More

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A randomized, controlled phase I/II study to evaluate the safety and efficacy of MGV354 for ocular hypertension or glaucoma.

Am J Ophthalmol 2018 May 23. Epub 2018 May 23.

Ophthalmology Research, Novartis Institutes for BioMedical Research, Inc., 22 Windsor Street, Cambridge, Massachusetts 02139, United States.

Purpose: To assess the clinical safety, tolerability, and efficacy of topically administered MGV354, a soluble guanylate cyclase (sGC) activator, in patients with ocular hypertension (OH) or glaucoma DESIGN: Double-masked, randomized, and vehicle-controlled study METHODS: Parts 1 and 2 evaluated safety and tolerability to identify the maximum tolerated dose (MTD) of once daily MGV354 in 32 healthy volunteers (Part 1) and 16 patients with OH or glaucoma (Part 2) at a single clinical site. Part 3 was a multi-site trial that evaluated IOP-lowering efficacy of the MTD administered nightly for one week in 50 patients with minimum IOP of 24mm Hg at 8 AM, with a main outcome measure of mean diurnal IOP at Day 8 compared to baseline (ClinicalTrials.gov NCT02743780). Read More

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Reply.

Am J Ophthalmol 2018 Jul 24;191:167-168. Epub 2018 May 24.

Gifu, Japan.

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Corrigendum.

Authors:

Am J Ophthalmol 2018 Jun;190:204

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Systemic Solutions in Retinopathy of Prematurity.

Am J Ophthalmol 2018 May 21. Epub 2018 May 21.

Chief, Retina Division, Horngren Family Vitreoretinal Center, Byers Eye Institute, Dept. of Ophthalmology, Stanford University School of Medicine, 2452 Watson Ct., Rm 2277 Palo Alto, CA 94303. Electronic address:

Purpose: To describe a framework for screening and treatment of retinopathy of prematurity using telemedicine screening with laser and/or vascular endothelial growth factor inhibitor treatment strategies.

Design: Literature review and perspective METHODS: Review of the literature and the author's experience RESULTS: Undetermined CONCLUSIONS: Telemedicine can be deployed on a national basis to provide quaternary level screening for ROP. At-risk patients for treatment could then be directed to receive either laser photocoagulation or vascular endothelial growth factor inhibitor intravitreal injections followed at a later time point by examination under anesthesia, fluorescein angiography, and diode laser photocoagulation as indicated. Read More

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Randomized, Controlled, Phase 2 Trial of Povidone-Iodine/Dexamethasone Ophthalmic Suspension for Treatment of Adenoviral Conjunctivitis.

Am J Ophthalmol 2018 May 19. Epub 2018 May 19.

Shire, Lexington, MA, USA. Electronic address:

Purpose: To evaluate the efficacy/safety of an ophthalmic suspension of povidone-iodine (PVP-I) 0.6% and dexamethasone 0.1% in patients with acute adenoviral conjunctivitis. Read More

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Outcomes of laser in situ keratomileusis and photorefractive keratectomy in patients taking isotretinoin.

Am J Ophthalmol 2018 May 14. Epub 2018 May 14.

Department of Research and Development, Clínica Baviera, Valencia, Spain.

Purpose: To determine the functional outcomes of laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) in patients taking isotretinoin, which is contraindicated for these procedures.

Design: Multicentre, retrospective, interventional case series METHODS: All patients taking isotretinoin who underwent LASIK or PRK from January 2003 to September 2017 were included (group 1). Patients were compared with those undergoing LASIK or PRK who had taken isotretinoin previously but not in the previous 6 months (group 2). Read More

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May 2018
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Topographic Correspondence of Macular Atrophy with Choroidal Neovascularization in Ranibizumab Treated Eyes of the TREX-AMD Trial.

Am J Ophthalmol 2018 May 12. Epub 2018 May 12.

Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Purpose: To quantify the extent of topographic correspondence between baseline (BSL) CNV and macular atrophy (MA) at follow-up in eyes with NVAMD.

Design: Post hoc analysis of randomized, controlled clinical trial data.

Methods: Sixty treatment-naïve neovascular age-related macular degeneration (NVAMD) patients from TREX-AMD trial were followed for 18-months. Read More

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Risk of Glaucoma Surgery after Corneal Transplant Surgery in Medicare Patients.

Am J Ophthalmol 2018 May 12. Epub 2018 May 12.

Stein Eye Institute; David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, California; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles; Los Angeles, California. Electronic address:

Purpose: Glaucoma is a well-documented complication of corneal transplants, contributing significantly to ultimate visual loss. Reported incidence of glaucoma following corneal transplants is highly variable, and definitions of post-transplant glaucoma are inconsistent. Here we use glaucoma surgery as a more rigid and specific endpoint to compare rates following different corneal transplant surgeries. Read More

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What We Have Learned From the Ocular Hypertension Treatment Study.

Am J Ophthalmol 2018 May 11. Epub 2018 May 11.

Cluj-Napoca, Romania.

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Therapeutic Penetrating Keratoplasty Button Cultures in The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo.

Am J Ophthalmol 2018 May 11. Epub 2018 May 11.

Francis I. Proctor Foundation, University of California San Francisco; UCSF Department of Ophthalmology, University of California San Francisco.

Objective: To compare oral voriconazole versus placebo in addition to topical antifungals in the treatment of filamentous fungal keratitis.

Design: Non-prespecified, secondary case-control analysis from a multicenter, double-masked, randomized placebo-controlled clinical trial STUDY PARTICIPANTS: Patients with smear-positive filamentous fungal ulcers and visual acuity of 20/400 or worse who eventuated to therapeutic penetrating keratoplasty (TPK).

Intervention: Study participants were randomized to oral voriconazole versus oral placebo; all received topical antifungal drops. Read More

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Occurrence of phosphenes in patients undergoing proton beam therapy for ocular tumor.

Am J Ophthalmol 2018 May 10. Epub 2018 May 10.

Department of Radiation therapy, Centre François Baclesse - ARCHADE, Unicaen - Normandie University, 14000 Caen, France.

Purpose: Phosphenes are frequently reported by patients irradiated in the head and neck area. The aim of the present study was to characterize and investigate potential mechanisms of proton beam therapy (PBT)-induced phosphenes in a large population of patients undergoing PBT for ocular tumors.

Design: Prospective cohort study METHODS: Consecutive patients who underwent PBT in a single center were included. Read More

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Chloral hydrate administered by a dedicated sedation service can be used safely and effectively for pediatric ophthalmic examination.

Am J Ophthalmol 2018 May 10. Epub 2018 May 10.

King Khaled Eye Specialist Hospital and Research Center, Al Urubah Branch Rd, Umm Al Hamam Al Gharbi, Riyadh 12329, Saudi Arabia. Electronic address:

Purpose: To determine safety and efficacy of oral chloral hydrate sedation (CHS) for outpatient pediatric ophthalmic procedures.

Design: Prospective, interventional case series METHODS-SETTING: - King Khaled Eye Specialist Hospital.

Subjects: Children ages 1 month to 5 years undergoing CHS for ocular imaging/evaluation PROCEDURES: Details on chloral hydrate dose administered, sedation achieved, vitals, and adverse events were recorded OUTCOME MEASURES: Primary Outcome: Percent of patients with a sedation level ≥4 at 45 minutes post chloral hydrate administration. Read More

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Color Fundus Photography, Optical Coherence Tomography, and Fluorescein Angiography in Diagnosing Polypoidal Choroidal Vasculopathy.

Am J Ophthalmol 2018 May 10. Epub 2018 May 10.

Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

Purpose: To determine sensitivity and specificity of polypoidal choroidal vasculopathy (PCV) diagnosis using color fundus photography (CFP), optical coherence tomography (OCT) and fundus fluorescein angiography (FFA) without indocyanine-green angiography (ICGA).

Design: Validity analysis.

Methods: Treatment-naïve eyes with serous/serosanguinous maculopathy undergoing CFP, OCT, FFA and ICGA imaging before treatment at a university-hospital in Thailand (January 2013 to June 2015) were identified. Read More

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May 2018
2 Reads

Macular Structures, Optical Components, and Visual Acuity in Preschool Children after Intravitreal Bevacizumab or Laser Treatment.

Am J Ophthalmol 2018 May 10. Epub 2018 May 10.

Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Purpose: To investigate the macular structures, optical components, and visual acuity in preschool-aged children with a history of type I retinopathy of prematurity who underwent either intravitreal bevacizumab (IVB), laser, or a combination of treatments.

Design: Comparative interventional case series.

Methods Setting: A referred medical center in Taiwan. Read More

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The Influence of Early Ophthalmic Hospitals on the Journal.

Am J Ophthalmol 2018 May 9. Epub 2018 May 9.

New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA. Electronic address:

Purpose: To consider the American Journal of Ophthalmology's (AJO's) role not only as a forum to describe clinical and scientific advances but also as a record of institutional histories. We used the New York Eye and Ear Infirmary of Mount Sinai, the Massachusetts Eye and Ear Infirmary, and the Wills Eye Hospital as case studies on the Journal's role in documenting the people and organizations that have moved ophthalmology forward.

Design: Perspective. Read More

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Comparison of three intraocular lens implantation procedures for aphakic eyes with insufficient capsular support: a network meta -analysis.

Am J Ophthalmol 2018 May 8. Epub 2018 May 8.

Eye Center, the Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China. Electronic address:

Purpose: To compare the clinical outcomes and main complications of transscleral-fixated (TSF), intrascleral-fixated (ISF) and iris-fixated (IF) intraocular lenses (IOLs).

Design: Systematic review and network meta-analysis.

Methods: We searched Pubmed, EMBASE and the Cochrane library for relevant articles up to April 2017 with no language restrictions, and related studies meeting the eligibility criteria were included. Read More

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May 2018
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Locations, Circumstances, and Outcomes of Falls in Patients with Glaucoma.

Am J Ophthalmol 2018 May 8. Epub 2018 May 8.

The Wilmer Eye Institute, Johns Hopkins University School of Medicine; Baltimore, Maryland; The Dana Center for Preventive Ophthalmology, Johns Hopkins University; Baltimore, MD. Electronic address:

Purpose: To characterize the locations, circumstances, and outcomes of falls in patients with varying degrees of glaucoma.

Design: Prospective cohort study METHODS: Patients with suspected or diagnosed glaucoma completed monthly calendars reporting falls. After each fall, a 30-item questionnaire was administered to determine fall location, circumstances, and injury. Read More

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Automated Beta Zone Parapapillary Area Measurement to Differentiate Between Healthy and Glaucoma Eyes.

Am J Ophthalmol 2018 Jul 9;191:140-148. Epub 2018 May 9.

Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA. Electronic address:

Purpose: To evaluate whether automated assessment of beta zone parapapillary atrophy (βPPA) area can differentiate between glaucomatous and healthy eyes of varying axial lengths (AL).

Design: Cross-sectional study.

Methods: βPPA was automatically identified in glaucoma and healthy eyes with enhanced-depth imaging optical coherence tomography (OCT) optic nerve head (ONH) radial B-scans. Read More

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Altered macular microvasculature in Neuromyelitis Optica Spectrum Disorders.

Am J Ophthalmol 2018 May 8. Epub 2018 May 8.

School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Purpose: To evaluate macular microvascular changes in neuromyelitis optica spectrum disorders (NMOSD) by using optical coherence tomography angiography (OCT-A) and investigate their correlations with neuroaxonal structural damage evaluated with Spectral domain OCT (SD-OCT).

Design: Cross-sectional study.

Methods: Twenty eyes of 20 patients with NMOSD and 21 eyes from 21 healthy controls were enrolled. Read More

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Glaucoma Specialist Optic Disc Margin, Rim Margin and Rim Width Discordance in Glaucoma and Glaucoma Suspect Eyes.

Am J Ophthalmol 2018 May 8. Epub 2018 May 8.

Devers Eye Institute, Optic Nerve Head Research Laboratory, Legacy Research Institute, 1225 NE 2nd Ave, Portland, OR 97208-3950; Devers Eye Institute, Discoveries in Sight Research Laboratories, Legacy Research Institute, 1225 NE 2nd Ave, Portland, OR 97208-3950; Devers Eye Institute Glaucoma Service, 1040 NW 22nd Ave, Portland, OR 97210. Electronic address:

Purpose: To quantify the variability of 5 glaucoma specialists' optic disc margin (DM), rim margin (RM) and rim width (RW) estimates.

Design: Inter-Observer Reliability analysis.

Methods: Clinicians viewed stereo-photos from 214 subjects with glaucoma or ocular hypertension and digitally marked the DM and RM. Read More

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May 2018
1 Read