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    25334 results match your criteria American journal of ophthalmology[Journal]

    1 OF 507

    Diagnosing distensible venous malformations of the orbit with diffusion-weighted magnetic resonance imaging.
    Am J Ophthalmol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Ophthalmology; University of California, San Francisco.
    Purpose: To compare the diffusion-weighted imaging characteristics of non-thrombosed distensible venous malformations of the orbit with that of other histologically-proven orbital tumors.

    Design: Retrospective case-control study.

    Methods: Patients with non-thrombosed distensible venous malformations of the orbit and patients with other histologically-proven orbital tumors were selected for chart review. Read More

    Distinguishing keratoconic eyes and healthy eyes using Ultrahigh-Resolution (UHR)-OCT based Corneal Epithelium Thickness Mapping.
    Am J Ophthalmol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Ophthalmology and Optometry, Medical University of Vienna, Austria. Electronic address:
    Purpose: Discovering new predictive parameters in the diagnostics of Keratoconus (KC) has high priority. Aim of this trial was to find differences in epithelial thickness (ET) maps of eyes with KC and healthy eyes.

    Design: Institutional cross-sectional study. Read More

    Comparing treatment of acute retinal necrosis with either oral valaciclovir or intravenous aciclovir.
    Am J Ophthalmol 2018 Feb 12. Epub 2018 Feb 12.
    Moorfields Eye Hospital, London, UK; UCL Institute of Ophthalmology, London, UK; Technion - Israel Institute of Technology, Haifa, Israel. Electronic address:
    Purpose: To compare the visual outcomes of patients with acute retinal necrosis (ARN) treated initially with intravenous aciclovir versus oral valaciclovir therapy.

    Design: Retrospective, comparative, interventional case series.

    Methods: 62 patients (68 eyes) with ARN, treated at Moorfields Eye Hospital (United Kingdom) between 1992 and 2016, were identified through the hospital's electronic database. Read More

    Progression of Primary Open Angle Glaucoma in Diabetic and Non-diabetic Patients.
    Am J Ophthalmol 2018 Feb 12. Epub 2018 Feb 12.
    Hamilton Glaucoma Center and Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego, CA, United States. Electronic address:
    Purpose: To compare the rates of visual field (VF) loss and retinal nerve fiber layer (RNFL) thinning in primary open angle glaucoma (POAG) patients with or without type 2 diabetes mellitus (DM).

    Design: Cohort study.

    Methods: A total of 197 eyes (55 eyes of 32 POAG patients with DM in POAG/DM group and 142 eyes of 111 age-matched POAG patients without DM in POAG/DM- group) were included from the Diagnostic Innovations in Glaucoma Study (DIGS). Read More

    The Significance of Repeat Cultures in the Treatment of Severe Fungal Keratitis.
    Am J Ophthalmol 2018 Feb 10. Epub 2018 Feb 10.
    Francis I. Proctor Foundation, San Francisco; UCSF Department of Ophthalmology, University of California San Francisco. Electronic address:
    Purpose: To identify fungal keratitis patients who are at risk of a poor outcome and may benefit from closer follow-up or more aggressive treatment.

    Design: Secondary analysis of randomized clinical trial data.

    Subjects: Patients presenting with a smear-positive filamentous fungal ulcer, visual acuity of 20/400 or worse, and who subsequently had a 6-day fungal culture performed at the Aravind Eye Care system (India), Lumbini Eye Hospital (Nepal), or Bharatpur Eye Hospital (Nepal). Read More

    Precise Measurement of Retinal Vascular Bed Area and Density on Ultra-Wide Fluorescein Angiography in Normal Subjects.
    Am J Ophthalmol 2018 Feb 8. Epub 2018 Feb 8.
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA. Electronic address:
    Purpose: To characterize and quantify the total retinal vascular bed area (RVBA) and vascular density (VD) in normal eyes using stereographically-corrected ultra-wide (UWF) fluorescein angiography (FA).

    Design: Cross-sectional study METHODS: Fifty-nine eyes of 31 normal subjects with no evidence of ocular disease underwent FA using the Optos 200Tx. Central and peripheral-steered FA images were montaged and stereographically projected. Read More

    Ophthalmic Findings of Rosai-Dorfman Disease.
    Am J Ophthalmol 2018 Feb 8. Epub 2018 Feb 8.
    Departments of Ophthalmology, Mayo Clinic, Rochester, MN, USA; Departments of Orbital Surgery, Mayo Clinic, Rochester, MN, USA; Departments of Neuro-Ophthalmology, Mayo Clinic, Rochester, MN, USA.
    Purpose: To describe the ophthalmic, pathologic, and BRAF V600E mutation status of Rosai-Dorfman Disease (RDD).

    Design: Retrospective case series.

    Methods: A retrospective review of all cases of RDD seen at Mayo Clinic from 1992 to 2016 identified patients with ophthalmic manifestations (n=8). Read More

    Choroidal Microvasculature Dropout Is Associated With Parafoveal Visual Field Defects in Glaucoma.
    Am J Ophthalmol 2018 Feb 8. Epub 2018 Feb 8.
    Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea. Electronic address:
    Purpose: To determine whether the frequency of parafoveal visual field (VF) damage differs according to the presence of choroidal microvasculature dropout (CMvD) in open-angle glaucoma (OAG) and to assess correlations between the angular circumference of CMvD and the severity of VF defects.

    Design: Retrospective case-control study.

    Methods: This study enrolled 88 eyes of 88 consecutive OAG patients (44 with CMvD and 44 without CMvD matched for age [≤ 5 years], axial length [≤ 1 mm], and the severity of VF loss [≤ 1 dB]). Read More

    Long Term Outcome of Pars Plana Vitrectomy and Sutured Scleral-Fixated Posterior Chamber Intraocular Lens Implantation or Repositioning.
    Am J Ophthalmol 2018 Feb 7. Epub 2018 Feb 7.
    The Retina Center at Pali Momi, 98-1079 Moanalua Road, Suite 470, Aiea, HI 96701; Retina Consultants of Hawaii, 98-1079 Moanalua Road, Suite 470, Aiea, HI 96701; Hawaii Macula and Retina Institute, 98-1079 Moanalua Road, Suite 470, Aiea, HI 96701.
    Purpose: To assess the long-term stability of sutured scleral-fixated posterior chamber intraocular lenses (PC IOL) performed in combination with pars plana vitrectomy.

    Design: Retrospective, consecutive, interventional case series METHODS: Retrospective single-surgeon study of 118 eyes of 111 patients seen at Retina Consultants of Hawaii, who underwent sutured scleral fixation of at least one haptic of a posterior chamber intraocular lens with 10-0 polypropylene combined with a pars plana vitrectomy. The fixation knot tying technique required two separate 10-0 polypropylene sutures tied into one combined knot - one suture closed the fixation sclerotomy and created the scleral fixation, and one suture looped together around the haptic of the PC IOL securing the haptic to the scleral fixation site. Read More

    Vancomycin-associated hemorrhagic occlusive retinal vasculitis: a clinical-pathophysiological analysis.
    Am J Ophthalmol 2018 Feb 6. Epub 2018 Feb 6.
    Associated Retinal Consultants, PC, Royal Oak, MI; Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Rochester, MI. Electronic address:
    Purpose: To derive novel insights into the pathophysiology of vancomycin-related hemorrhagic occlusive retinal vasculopathy (HORV) through a careful clinicopathologic correlation.

    Methods: and study design: We retrospectively reviewed the clinical and pathologic course of two consecutive patients who developed HORV. The clinical history, multimodal imaging, ultrasound biomicroscopy (UBM), intraoperative and histological findings are reported. Read More

    Association between Optic Nerve Head Deformation and Retinal Microvasculature in High Myopia.
    Am J Ophthalmol 2018 Feb 5. Epub 2018 Feb 5.
    Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, Gwangju, South Korea; Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, South Korea. Electronic address:
    Purpose: To evaluate the retinal microvasculature of peripapillary and macular regions in highly myopic eyes and investigate the association between the vascular parameters and optic nerve head (ONH) deformation.

    Design: Cross-sectional study METHODS: Seventy-one subjects with highly myopic eyes and 26 subjects with emmetropic eyes were included. Horizontal B-scan images of the ONH were obtained using optical coherence tomography (OCT) and horizontal tilt angles were measured. Read More

    Jalili Syndrome: Cross-sectional and Longitudinal Features of Seven Patients with Cone-Rod Dystrophy and Amelogenesis Imperfecta.
    Am J Ophthalmol 2018 Feb 5. Epub 2018 Feb 5.
    Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, University College London, London, UK. Electronic address:

    Chronic Ocular Sequelae of Stevens-Johnson Syndrome in Children: Long-term Impact of Appropriate Therapy on Natural History of Disease.
    Am J Ophthalmol 2018 Feb 5. Epub 2018 Feb 5.
    Tej Kohli Cornea Institute, L V Prasad Eye Institute, Hyderabad-500034, India; Prof. Brien Holden Eye Research Center, Champalimaud Translational Centre for Eye Research, L V Prasad Eye Institute, Hyderabad-500034, India. Electronic address:
    Purpose: To describe the long-term ocular and visual morbidity in children with chronic sequelae of Stevens-Johnson Syndrome (SJS) and visual outcomes of various management strategies.

    Design: Retrospective comparative case series.

    Methods: This study included 568 eyes of 284 children with SJS who presented between 1990 and 2015. Read More

    Fluorouracil Filtering Surgery Study One-Year Follow-up.
    • Authors:
    Am J Ophthalmol 2018 Feb;186:xxxiii-xlii
    Two hundred thirteen patients participated in the Fluorouracil Filtering Surgery Study, a randomized clinical trial, to determine the efficacy and safety of subconjunctivally injected 5-fluorouracil after filtering surgery in eyes with poor prognoses. Twenty-eight (27%) of the 105 eyes in the 5-fluorouracil group and 54 (50%) of the 108 eyes in the standard group were classified as failures, defined by reoperation for control of intraocular pressure during the first year or an intraocular pressure greater than 21 mm Hg at the one-year visit (P = .0007, Mantel-Haenszel chi-square). Read More

    Trends in corneal transplantation from 2001 to 2016 in Germany: A report of the DOG-Section Cornea and its Keratoplasty Registry.
    Am J Ophthalmol 2018 Feb 1. Epub 2018 Feb 1.
    Department of Ophthalmology, Saarland University Medical Center, 66421 Homburg, Germany.
    Purpose: The purpose of this retrospective panel study was to provide an overview of absolute numbers, trends in the types of and indications for corneal transplantation in Germany from 2001 to 2016.

    Methods: A questionnaire about absolute numbers, types of transplantation and indications was sent to 111 ophthalmological departments in Germany out of which 94 (85%) provided their data.

    Results: Since the year 2001, the number of corneal transplantations has increased by 1. Read More

    A 12-Year Study of Slotted Palladium-103 Plaque Radiation Therapy for Choroidal Melanoma: Near, Touching, or Surrounding the Optic Nerve.
    Am J Ophthalmol 2018 Jan 31. Epub 2018 Jan 31.
    The New York Eye Cancer Center, Suite 5B, 115 East 61st Street, New York, NY 10065. Electronic address:
    Purpose: To present our 12-year experience with low energy photon, slotted eye plaque radiation therapy.

    Design: Retrospective interventional case series METHODS: SETTING: The New York Eye Cancer Center.

    Study Population: Fifty-two consecutive patients with uveal melanomas near, touching or surrounding the optic disc. Read More

    Eye Drop Dispenser Type and Medication Possession Ratio in Patients with Glaucoma: Single-use Containers versus Multiple-use Bottles.
    Am J Ophthalmol 2018 Jan 29. Epub 2018 Jan 29.
    Department of Ophthalmology, Korea University College of Medicine, Seoul, South Korea.
    Purpose: To determine whether the consumption of topical glaucoma medication is influenced by the type of eye drop dispenser DESIGN: Retrospective cohort study METHODS: We examined 366 patients with open-angle glaucoma or ocular hypertension who were bilaterally treated with 0.0015% tafluprost or 2% dorzolamide/0.5% timolol fixed combination (DTFC). Read More

    Limbal Stem Cell Deficiency - Demography And Underlying Causes.
    Am J Ophthalmol 2018 Jan 26. Epub 2018 Jan 26.
    Cornea and Anterior Segment Services, Tej Kohli Cornea Institute, L V Prasad Eye Institute, Hyderabad, India. Electronic address:
    Purpose: To determine the demographic features of patients affected by limbal stem cell deficiency (LSCD), and to identify the underlying causes of LSCD DESIGN: Retrospective, multi-center case series SETTING: Two large tertiary care ophthalmology hospitals SUBJECTS: Patients with a diagnosis of LSCD presenting from January 1, 2005 to December 31, 2014 METHODS: Records of patients with a clinical diagnosis of LSCD were reviewed. Demographic details and clinical features at presentation, as well as the underlying cause of LSCD (if identified) were noted. Descriptive statistical analysis and chart preparation were done. Read More

    Leadership in Ophthalmology: The Role of Physician-MBAs.
    Am J Ophthalmol 2018 Jan 26. Epub 2018 Jan 26.
    Icahn School of Medicine at Mount Sinai, New York Eye and Ear Infirmary of Mount Sinai, 310 E 14(th, Street), New York, NY 10003. Electronic address:
    Purpose: As American health care evolves, an increasing number of doctors are pursuing MBAs. However, relatively little is known about how business training translates into their future careers. This study characterizes ophthalmologists who have completed MBAs and identifies opportunities for physician leadership in the field. Read More

    Correlation between ischemic index of retinal vein occlusion and oxygen saturation in retinal vessels.
    Am J Ophthalmol 2018 Jan 20. Epub 2018 Jan 20.
    Department of Ophthalmology, University Hospital and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic. Electronic address:
    Purpose: The aim of this study was to evaluate the relationship between the ischemic index and the oxygen saturation in retinal vessels in patients with retinal vein occlusion.

    Design: Prospective, cross-sectional study.

    Methods: We performed a prospective study. Read More

    Keratoendotheliitis Fugax Hereditaria: A Novel Cryopyrin-Associated Periodic Syndrome Caused by a Mutation in the Nucleotide-Binding Domain, Leucine-Rich Repeat Family, Pyrin Domain-Containing 3 (NLRP3) Gene.
    Am J Ophthalmol 2018 Jan 20. Epub 2018 Jan 20.
    Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4C, 00029 Helsinki, Finland.
    Purpose: To describe the phenotype and the genetic defect in keratoendotheliitis fugax hereditaria, an autosomal dominant keratitis that periodically affects the corneal endothelium and stroma, leading in some patients to opacities and decreased visual acuity.

    Design: Cross-sectional, hospital-based study.

    Methods: Patient population: Thirty affected and 7 unaffected subjects from 7 families, and 4 sporadic patients from Finland. Read More

    The relationship between non-steroidal anti-inflammatory drug use and age-related macular degeneration.
    Am J Ophthalmol 2018 Jan 19. Epub 2018 Jan 19.
    Department of Research and Evaluation, Southern California Permanente Medical Group, Pasadena, CA.
    Purpose: To describe the relationship between the incidence of age-related macular degeneration (AMD) and non-steroidal anti-inflammatory drug (NSAIDs) use.

    Design: Prospective cohort study.

    Methods: This study consisted of participants in the California Men's Health Study. Read More

    Assessment of lamellar macular hole and macular pseudohole with a combination of en face and radial B-scan optical coherence tomography imaging.
    Am J Ophthalmol 2018 Jan 19. Epub 2018 Jan 19.
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
    Purpose: To investigate lamellar macular hole (LMH) and macular pseudohole (MPH) using a combination of en face and radial B-scan OCT.

    Design: Retrospective observational case series.

    Methods: Setting: Institutional study PATIENT POPULATION: En face and radial B-scan OCT images of 63 eyes of 60 patients diagnosed with LMH or MPH based on an international classification were reviewed. Read More

    Variation in Intraocular Pressure and the Risk of Developing Open-angle Glaucoma: The Los Angeles Latino Eye Study.
    Am J Ophthalmol 2018 Jan 19. Epub 2018 Jan 19.
    USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA. Electronic address:
    Purpose: To determine whether measures of intraocular pressure (IOP) variation are independently associated with the risk of developing open-angle glaucoma (OAG).

    Design: A population-based, longitudinal study.

    Methods: 3,666 Latinos free of OAG at the baseline of the Los Angeles Latino Eye Study were followed up four years later. Read More

    Inferior decentration of multifocal intraocular lenses in myopic eyes.
    Am J Ophthalmol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Ophthalmology, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China; Eye Institute, Eye and Ear, Nose, and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, People's Republic of China; Key Laboratory of Myopia, Ministry of Health, Shanghai 200031, People's Republic of China; Shanghai; Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, People's Republic of China. Electronic address:
    Purpose: To investigate the tilt and decentration of multifocal intraocular lenses (MfIOLs) implanted in myopic eyes.

    Design: A prospective cohort study.

    Methods: Twenty-eight myopic eyes and 56 emmetropic eyes were evaluated. Read More

    Improving Follow-up and Reducing Barriers for Eye Screenings in Communities: the SToP Glaucoma Study.
    Am J Ophthalmol 2018 Jan 17. Epub 2018 Jan 17.
    Dana Center for Preventive Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address:
    Purpose: To evaluate factors associated with attendance to follow-up ophthalmic care, and to assess the impact of strategies to improve follow-up.

    Design: Cross-sectional study.

    Methods: This is an ongoing study to develop an eye screening paradigm, focusing on African Americans ≥50 years of age at multiple urban community sites in Baltimore, MD. Read More

    Anterior Segment Imaging for Angle Closure.
    Am J Ophthalmol 2018 Jan 31. Epub 2018 Jan 31.
    Department of Ophthalmology, University of California, San Francisco Medical School, San Francisco, California. Electronic address:
    Purpose: To summarize the role of anterior segment imaging (AS-imaging) in angle closure diagnosis and management, and the possible advantages over the current standard of gonioscopy.

    Design: Literature review and perspective.

    Methods: Review of the pertinent publications with interpretation and perspective in relation to the use of AS-imaging in angle closure assessment focusing on anterior segment optical coherence tomography and ultrasound biomicroscopy. Read More

    Accommodative Esotropia Treatment Plan Utilizing Simultaneous Strabismus Surgery and Photorefractive Keratectomy.
    Am J Ophthalmol 2018 Jan 12. Epub 2018 Jan 12.
    Department of Ophthalmology, Ochsner Clinic Foundation, 1514 Jefferson Hwy., New Orleans, LA 70121.
    Purpose: Accommodative esotropia is a common cause of acquired esotropia. Pathogenesis varies among patients but usually includes excessive hyperopia and a high accommodative convergence/accommodation ratio or tight medial recti. The present study reviews an individualized treatment plan combining photorefractive keratectomy (PRK) and strabismus surgery to correct these problems. Read More

    Factors Associated with Early Graft Detachment in Primary Descemet Membrane Endothelial Keratoplasty.
    Am J Ophthalmol 2018 Jan 12. Epub 2018 Jan 12.
    Ospedali Privati Forlì, Department of Ophthalmology, Forlì, Italy; Istituto internazionale per la Ricerca e Formazione in Oftalmologia (IRFO), Forlì, Italy; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy. Electronic address:
    Purpose: To evaluate the risk factors for early graft detachment in Descemet Membrane Endothelial Keratoplasty (DMEK).

    Design: Case-control Study.

    Methods: ▪ PARTICIPANTS: 173 donor corneas and 173 eyes of the patients following DMEK or DMEK in combination with phacoemulsification and IOL implantation were included. Read More

    Evolution of Intravitreal Therapy for Retinal Diseases-From CMV to CNV: The LXXIV Edward Jackson Memorial Lecture.
    Am J Ophthalmol 2018 Jan 12. Epub 2018 Jan 12.
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:
    Purpose: To present the evolution of intravitreal therapy for retinal diseases and its impact on clinical practice.

    Design: Retrospective literature review and personal perspective.

    Methods: Retrospective literature review and personal perspective. Read More

    Relation between dietary essential fatty acid intake and dry eye disease and meibomian gland dysfunction in postmenopausal women.
    Am J Ophthalmol 2018 Jan 11. Epub 2018 Jan 11.
    University of Alabama at Birmingham, 1716 University Boulevard, HPB 112, Birmingham, AL 35294. Electronic address:
    Purpose: To evaluate the relationship between omega-3 (n-3) and omega-6 (n-6) fatty acids with dry eye disease (DED) and meibomian gland dysfunction (MGD) DESIGN: Cross-sectional study METHODS: Postmenopausal women (n=439) underwent a clinical evaluation and completed the Vio Food Frequency Questionnaire to estimate their dietary intake of n-3s and n-6s. Subjects were categorized into two binary classifications based upon whether or not they had (1) DED and (2) MGD. Mean intake of dietary fatty acids were compared with two-sample t-tests. Read More

    Antiplatelet and anticoagulant drugs do not affect visual outcome in neovascular age-related macular degeneration in the BRAMD trial.
    Am J Ophthalmol 2018 Jan 9. Epub 2018 Jan 9.
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Ocular Angiogenesis Group, Departments of Ophthalmology and Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Netherlands Institute for Neurosciences, Amsterdam, The Netherlands; Department of Ophthalmology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
    Purpose: To determine if use of antiplatelet or anticoagulant (AP/AC) medication influences visual acuity in patients with active neovascular age-related macular degeneration (N-AMD).

    Design: Retrospective analysis of data from a randomized controlled trial METHODS: Setting: Multi-center STUDY POPULATION: 330 patients with active N-AMD from the BRAMD study, a comparative trial between bevacizumab and ranibizumab in the Netherlands.

    Observation Procedures: Patients underwent an extensive ophthalmic examination. Read More

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