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    25175 results match your criteria American journal of ophthalmology[Journal]

    1 OF 504

    Visual performance of a quadrifocal (trifocal) intraocular lens following removal of the crystalline lens.
    Am J Ophthalmol 2017 Sep 15. Epub 2017 Sep 15.
    Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany.
    Purpose: To evaluate visual performance after implantation of a quadrifocal intraocular lens (IOL).

    Design: Prospective, non-comparative case series METHODS: Setting: Department of Ophthalmology, Goethe University, Frankfurt, Germany. Patient or Study Population: Twenty-seven patients (54 eyes) received bilateral implantation of the PanOptix IOL (AcrySof® IQ PanOptixTM, Alcon Research, Fort Worth, TX, USA) pre-enrollment. Read More

    Outcomes of Ahmed Glaucoma Valve Revision in Pediatric Glaucoma.
    Am J Ophthalmol 2017 Sep 13. Epub 2017 Sep 13.
    King Khaled Eye Specialist Hospital, Riyadh Saudi Arabia; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:
    Purpose: Encapsulation of the Ahmed glaucoma valve (AGV) plate is a common cause for postoperative elevation of intraocular pressure, especially in children. Many reports have described the outcomes of AGV revision in adults. However, the outcomes of AGV revision in children are poorly documented. Read More

    Factors Associated with Zonular Instability During Cataract Surgery in Eyes with Acute Angle Closure Attack.
    Am J Ophthalmol 2017 Sep 12. Epub 2017 Sep 12.
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. Electronic address:
    Purpose: To compare the demographics and ocular characteristics, including anterior segment optical coherence tomography images and zonular instability in eyes with a history of acute angle closure (AAC) attack and subsequent cataract surgery.

    Design: Retrospective, case-control study METHODS: Total 68 eyes of 56 patients with a history of AAC attack who underwent cataract surgery were enrolled. Fourteen eyes were assigned to the zonular instability (+) group and 54 were assigned to the zonular instability (-) group based on the presence of zonular instability during cataract surgery. Read More

    Assessment of OCT color probability codes in myopic glaucoma eyes after applying a myopic normative database.
    Am J Ophthalmol 2017 Sep 11. Epub 2017 Sep 11.
    Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. Electronic address:
    Purpose: To evaluate the optical coherence tomography (OCT) color probability codes based on a myopic normative database and to investigate whether the implementation of the myopic normative database can improve the OCT diagnostic ability in myopic glaucoma.

    Design: Comparative validity study.

    Methods: In this study, 305 eyes (154 myopic healthy eyes and 151 myopic glaucoma eyes) were included. Read More

    Ocular Manifestations of Familial Transthyretin Amyloidosis.
    Am J Ophthalmol 2017 Sep 11. Epub 2017 Sep 11.
    Department of Ophthalmology. Electronic address:
    Purpose: Among patients with familial amyloidosis, mutation in the transthyretin (TTR) protein is the most common type. Patients with TTR amyloidosis have been noted to have ocular, especially vitreous, involvement. In this report, an analysis of the types and frequency of ocular manifestations in TTR amyloidosis is presented. Read More

    Is Corneal Arcus Independently Associated with Incident Cardiovascular Disease in Asians?
    Am J Ophthalmol 2017 Sep 11. Epub 2017 Sep 11.
    Singapore Eye Research Institute, Singapore; Duke-NUS Medical School, Singapore. Electronic address:
    Purpose: To examine the longitudinal relationship between baseline corneal arcus (CA) and incident CVD in ethnic Indian and Malay adults in Singapore.

    Design: Population-based cohort study.

    Methods: Indian and Malay adults aged 40-80 years were recruited for baseline and 6-year follow-up visits between 2004-09 and 2010-15, respectively (follow-up response rate 73. Read More

    A Randomized Controlled Trial Comparing outcomes of Cataract Surgery in Nanophthalmos with and without Prophylactic Sclerostomy.
    Am J Ophthalmol 2017 Sep 11. Epub 2017 Sep 11.
    Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
    Purpose: To prospectively evaluate visual outcomes and complications during and after cataract surgery with or without prophylactic sclerostomy in nanophthalmic eyes with visually significant cataract.

    Study Design: Randomized controlled trial METHODS: Sixty nanophthalmic eyes of 60 patients with visually significant cataract were randomly assigned to cataract surgery alone (control group, n=31) or cataract surgery with concomitant prophylactic sclerostomy (sclerostomy group, n=29). Surgery was performed using phacoemulsification or manual small incision cataract surgery (SICS) based on the LOCS III grading score. Read More

    Peri-Dome Choroidal Deepening in Highly Myopic Eyes with Dome-Shaped Maculas.
    Am J Ophthalmol 2017 Sep 11. Epub 2017 Sep 11.
    Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
    Purpose: To determine characteristics of peri-dome choroidal deepening (PDCD) surrounding dome-shaped maculas (DSMs) in highly myopic eyes.

    Design: Observational case series.

    Methods: Applying swept-source optical coherence tomography, we examined the posterior pole of highly myopic eyes with DSMs. Read More

    The Effect of Chronic Pulmonary Disease and Mechanical Ventilation on Corneal Donor Endothelial Cell Density and Transplant Suitability.
    Am J Ophthalmol 2017 Sep 7. Epub 2017 Sep 7.
    University of Maryland Department of Ophthalmology & Visual Sciences. Electronic address:
    Purpose: To determine how chronic obstructive pulmonary disease (COPD) and mechanical ventilation time affect corneal donor endothelial cell density (ECD) and transplant suitability.

    Design: Retrospective cohort study METHODS: Setting: institutional Study Population: 39,679 cornea donor eyes from SightLife Eye Bank between 2012-2016. Demographics, death to preservation time, ECD, lens status, medical history, time on mechanical ventilation, and suitability for transplantation were included. Read More

    Choroidal Thinning Associated with Hydroxychloroquine Retinopathy.
    Am J Ophthalmol 2017 Sep 7. Epub 2017 Sep 7.
    Department of Ophthalmology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Republic of Korea. Electronic address:
    Purpose: To investigate choroidal thickness in patients using hydroxychloroquine (HCQ) and compare choroidal thickness between eyes with and without HCQ retinopathy.

    Design: Retrospective case series METHODS: Setting: Institutional Patients: We included 124 patients with systemic lupus erythematosus or rheumatoid arthritis who were treated with HCQ. The patients were divided into an HCQ retinopathy group and a control group, according to the presence or absence of HCQ retinopathy. Read More

    Trabecular Meshwork Height in Primary Open-Angle Glaucoma Versus Primary Angle-Closure Glaucoma.
    Am J Ophthalmol 2017 Sep 5. Epub 2017 Sep 5.
    Department of Ophthalmology, University of California, San Francisco. Electronic address:
    Purpose: To determine if trabecular meshwork (TM) height differs between primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) eyes. Design; Prospective, cross-sectional clinical study.

    Methods: Adult patients were consecutively recruited from glaucoma clinics at the University of California, San Francisco, from January 2012 to July 2015. Read More

    Analysis of Cytokine levels in tears and Clinical Correlations after Intense Pulsed Light Treating Meibomian Gland Dysfunction.
    Am J Ophthalmol 2017 Sep 5. Epub 2017 Sep 5.
    Department of Ophthalmology, Peking University First Hospital, Beijing, People's Republic of China. Electronic address:
    Purpose: To investigate the change from baseline of inflammatory markers in tears of dry eye disease(DED) subjects due to meibomian gland dysfunction(MGD) after IPL(intense pulsed light) treatment and meibomian gland expression(MGE) compared to sham treatment, and the correlations with ocular surface parameters.

    Design: Randomized, double-masked, controlled study.

    Methods: Those randomized into the active treatment arm received 3 consecutive treatments(14∼16J/cm(2)) approximately 4 weeks apart in the periocular region. Read More

    Residual angle closure one year after laser peripheral iridotomy in primary angle closure suspects.
    Am J Ophthalmol 2017 Sep 5. Epub 2017 Sep 5.
    Singapore Eye Research Institute and Singapore National Eye Center, Singapore; Duke-NUS Medical School, Singapore; National University Hospital, Singapore and the Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:
    Purpose: To determine the incidence and baseline clinical and anterior segment optical coherence tomography (AS-OCT) predictors associated with residual angle closure as assessed by gonioscopy 1 year after laser peripheral iridotomy (LPI) in primary angle closure suspects (PACS).

    Design: Sub-analysis of randomized controlled trial data METHODS: AS-OCT images (Visante, Carl Zeiss Meditec, Dublin, CA) from 181 PACS subjects ≥ 50 years of age, were analyzed using customized software, prior to, and 1 year after LPI. Other parameters assessed were intraocular pressure (IOP) and axial length (Axl). Read More

    Blau Syndrome-Associated Uveitis: Preliminary Results From an International Prospective Interventional Case Series.
    Am J Ophthalmol 2017 Sep 6. Epub 2017 Sep 6.
    Department of Pediatric Rheumatology, Catholic University of Leuven (KU Leuven), Leuven, Belgium.
    Purpose: Provide baseline and preliminary follow-up results in a 5-year longitudinal study of Blau syndrome.

    Design: Multicenter, prospective interventional case series.

    Methods: Baseline data from 50 patients from 25 centers worldwide, and follow-up data for patients followed 1, 2, or 3 years at the end of study enrollment. Read More

    AJO Centennial: Cataract Surgery From 1918 to the Present and Future-Just Imagine!
    Am J Ophthalmol 2017 Sep 6. Epub 2017 Sep 6.
    Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah. Electronic address:
    Purpose: To review the history of cataract surgery over the past 100 years, and to offer predictions about new developments that may occur during the next 50 years.

    Design: Interpretive essay.

    Methods: Review of historical literature and author experiences pertaining to cataract surgery, with commentary and perspective. Read More

    Primary (Month-6) Outcomes of the STOP-Uveitis Study: Evaluating the Safety, Tolerability, and Efficacy of Tocilizumab in Patients with Non-Infectious Uveitis.
    Am J Ophthalmol 2017 Sep 5. Epub 2017 Sep 5.
    Byers Eye Institute, Stanford University, Palo Alto, CA; Ocular Imaging Research and Reading Center, Menlo Park, CA. Electronic address:
    Purpose: To report the primary end-point analyses of the safety and efficacy of two different doses of intravenous (IV) infusions of tocilizumab (TCZ), an IL-6 inhibitor, in eyes with non-infectious intermediate, posterior or pan-uveitis.

    Design: Randomized, controlled, multicenter clinical trial.

    Methods: STOP-Uveitis is a randomized, open-label safety, efficacy and bioactivity clinical trial conducted at 5 clinical centers across the United States. Read More

    Pediatric Corneal Crosslinking: Comparison of Visual and Topographic Outcomes between Conventional and Accelerated Treatment.
    Am J Ophthalmol 2017 Aug 29. Epub 2017 Aug 29.
    Department of Ophthalmology, Cantonal Hospital of Lucerne, CH-6000 Lucerne-16, Switzerland.
    Purpose: To compare visual and topographic outcomes 1 year after conventional (C-CXL) versus accelerated corneal crosslinking (A-CXL) in pediatric keratoconus DESIGN: Comparative, retrospective, consecutive case-series METHODS: Patients with topography confirmed, progressive KC and a corneal thickness of ≥400 micrometers at the time of surgery were enrolled. Uncorrected (UCVA) and best phoropter-corrected visual acuity (BCVA) and Kmax were measured at study entry and the 12-months follow-up. Treatment failure rate was defined as the percentage of eyes with an increase in Kmax of more than 1. Read More

    Preoperative Bevacizumab Administration in Proliferative Diabetic Retinopathy Patients Undergoing Vitrectomy: a Randomized and Controlled Trial Comparing Interval Variation.
    Am J Ophthalmol 2017 Aug 28. Epub 2017 Aug 28.
    Instituto de la Vision - Hospital La Carlota, Camino al Vapor #209 Colonia Zambrano Montemorelos, Nuevo Leon 67530, México; Panhandle Eye Group, 7400 Fleming Ave., Amarillo, Texas 79106, USA; Texas Tech University Health Science Center, 1400 S. Coulter, Amarillo, Texas 79106, USA; Southwest Retina Specialists, 7411 Wallace Blvd., Amarillo, TX, 79106, USA.
    Purpose: To assess the optimal interval of preoperative intravitreal bevacizumab (IVB) administration in diabetic subjects undergoing pars plana vitrectomy (PPV) for severe manifestations of active proliferative diabetic retinopathy (PDR).

    Design: Randomized clinical trial METHODS: One hundred and fifty six patients with PDR-related complications requiring PPV were prospectively randomized into one of two treatment groups: Group A received IVB (2.5 mg/0. Read More

    The Effect of Pulsing on Transverse Ultrasound Efficiency and Chatter.
    Am J Ophthalmol 2017 Aug 28. Epub 2017 Aug 28.
    Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Electronic address:
    Purpose: To evaluate the effects of micropulse, long pulse and continuous ultrasound on transverse ultrasound using Abbott Medical Optics' (AMO) WhiteStar Signature Pro with the Ellips FX handpiece.

    Design: In vitro laboratory study METHODS: This study was conducted at the John A. Moran Eye Center Laboratory, University of Utah, Salt Lake City, UT, USA. Read More

    Clinical Implications of Direct Immunofluorescence (DIF) Findings in Patients with Ocular Mucous Membrane Pemphigoid.
    Am J Ophthalmol 2017 Aug 28. Epub 2017 Aug 28.
    Ophthalmology, Duke University Eye Center, Durham, NC, United States; Dr. Christine Shieh is now affiliated with Vanderbilt Eye Institute in Nashville, TN, United States.
    Purpose: To examine the clinical implications of positive or negative direct immunofluorescence biopsies (DIF) in patients with clinically typical ocular mucous membrane pemphigoid (MMP).

    Design: Retrospective cohort study METHODS: The study population was patients with clinically typical ocular MMP disease with documented DIF results who were followed for at least one year at the Duke University multidisciplinary ocular MMP clinic. Data was collected by chart review and included: patient demographics, clinical examination findings, history of autoimmune disease and/or malignancy, as well as topical, systemic, and surgical treatments received. Read More

    Circumferential Trabeculotomy Versus Conventional Angle Surgery: Comparing Long-term Surgical Success and Clinical Outcomes in Children with Primary Congenital Glaucoma.
    Am J Ophthalmol 2017 Aug 28. Epub 2017 Aug 28.
    Emory University School of Medicine, Department of Ophthalmology, 1365-B Clifton Road NE, Atlanta, GA 30322. Electronic address:
    Purpose: This study compares the long-term efficacy of circumferential trabeculotomy to that of conventional angle surgeries in primary congenital glaucoma (PCG), as judged by glaucoma and visual outcomes.

    Design: Retrospective observational case series.

    Methods: Setting: Emory Eye Center, Atlanta, Georgia. Read More

    OCT-Angiography and Ultra-Widefield Fluorescein Angiography for Early Detection of Adolescent Sickle Retinopathy.
    Am J Ophthalmol 2017 Aug 28. Epub 2017 Aug 28.
    Department of Ophthalmology, Columbia University Medical Center, New York, NY. Electronic address:
    Purpose: Using standard screening techniques, sickle retinopathy reportedly occurs in 10% of adolescents with sickle cell disease (SCD). We performed a prospective, observational clinical study to determine if ultra-widefield fluorescein angiography (UWFA), spectral-domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCT-A) detect more frequent retinopathy in adolescents with SCD.

    Design: Cross-sectional study. Read More

    Performance of an iPad Application to Detect Moderate and Advanced Visual Field Loss in Nepal.
    Am J Ophthalmol 2017 Oct 25;182:147-154. Epub 2017 Aug 25.
    Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland; Department of Ophthalmology, University of Michigan, Ann Arbor, Michigan.
    Purpose: To evaluate the accuracy and efficiency of Visual Fields Easy (VFE), a free iPad app, for performing suprathreshold perimetric screening.

    Design: Prospective, cross-sectional validation study.

    Methods: We performed screening visual fields using a calibrated iPad 2 with the VFE application on 206 subjects (411 eyes): 210 normal (NL), 183 glaucoma (GL), and 18 diabetic retinopathy (DR) at Tilganga Institute of Ophthalmology, Kathmandu, Nepal. Read More

    Early Versus Late Canalicular Laceration Repair Outcomes.
    Am J Ophthalmol 2017 Oct 24;182:155-159. Epub 2017 Aug 24.
    Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan; Chang Gung University, Taoyuan, Taiwan.
    Purpose: To determine whether delayed repair of traumatic canalicular laceration affects the final outcome.

    Design: Retrospective case series.

    Methods: The medical records of 334 patients who underwent primary traumatic canalicular laceration repair were retrospectively reviewed. Read More

    Morphologic and Functional Retinal Vessel Changes in Branch Retinal Vein Occlusion: An Optical Coherence Tomography Angiography Study.
    Am J Ophthalmol 2017 Oct 31;182:168-179. Epub 2017 Aug 31.
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
    Purpose: The present study aimed to investigate the morphology of the retinal vasculature in eyes with branch retinal vein occlusion (BRVO) using optical coherence tomography (OCT) angiography.

    Design: Observational case series.

    Methods: Fluorescein angiography (FA) and OCT angiography were used to examine macular area and the retinal vasculature at the affected arteriovenous (AV) crossing in 46 patients with BRVO. Read More

    Disorganization of the Retinal Inner Layers as a Predictor of Visual Acuity in Eyes With Macular Edema Secondary to Vein Occlusion.
    Am J Ophthalmol 2017 Oct 22;182:160-167. Epub 2017 Aug 22.
    Department of Ophthalmology, Meir Medical Center, Kfar Saba, Affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:
    Purpose: To determine whether spectral-domain optical coherence tomography (SD-OCT) disorganization of the retinal inner layers (DRIL) is predictive of best-corrected visual acuity (BCVA) in retinal vein occlusion macular edema (RVO-ME).

    Design: Retrospective cohort study.

    Methods: Setting: Two tertiary centers. Read More

    Early Trabeculotomy Ab Externo in Treatment of Sturge-Weber Syndrome.
    Am J Ophthalmol 2017 Oct 12;182:141-146. Epub 2017 Aug 12.
    Department of Ophthalmology, Ninth People's Hospital Affiliated With Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
    Purpose: To evaluate the intermediate-term efficacy and safety of trabeculotomy in infant Sturge-Weber syndrome (SWS).

    Design: Retrospective cohort study.

    Methods: All SWS-induced glaucoma patients less than 12 months of age who underwent trabeculotomy at our Ophthalmology Department from August 2011 to March 2017 were reviewed. Read More

    Diagnostic Capability of Peripapillary Three-dimensional Retinal Nerve Fiber Layer Volume for Glaucoma Using Optical Coherence Tomography Volume Scans.
    Am J Ophthalmol 2017 Oct 12;182:180-193. Epub 2017 Aug 12.
    Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts. Electronic address:
    Purpose: To determine the diagnostic capability of peripapillary 3-dimensional (3D) retinal nerve fiber layer (RNFL) volume measurements from spectral-domain optical coherence tomography (OCT) volume scans for open-angle glaucoma (OAG).

    Design: Assessment of diagnostic accuracy.

    Methods: Setting: Academic clinical setting. Read More

    Optical Coherence Tomography Angiography of the Peripapillary Retina in Primary Angle-Closure Glaucoma.
    Am J Ophthalmol 2017 Oct 7;182:194-200. Epub 2017 Aug 7.
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon. Electronic address:
    Purpose: To measure the change of peripapillary retinal vessel density (VD) in eyes with a history of acute primary angle-closure glaucoma (PACG).

    Design: Case-control study.

    Methods: Twenty-one consecutive Chinese patients with history of unilateral acute PACG were enrolled. Read More

    Performance and Safety of a New Ab Interno Gelatin Stent in Refractory Glaucoma at 12 Months.
    Am J Ophthalmol 2017 Aug 4. Epub 2017 Aug 4.
    Allergan plc, Irvine, California.
    Purpose: To evaluate the intraocular pressure (IOP)-lowering performance and safety of an ab interno gelatin stent (XEN® 45 Gel Stent, Allergan plc), a minimally invasive glaucoma surgery device, in refractory glaucoma.

    Design: Single-arm, open-label, multicenter clinical study.

    Methods: Following mitomycin pretreatment, the stent was placed ab interno in patients who failed prior filtering/cilioablative procedure or had uncontrolled IOP on maximum-tolerated medical therapy, with medicated IOP ≥20 and ≤35 mmHg and visual field mean deviation ≤-3 dB. Read More

    An Analysis of Medicare Reimbursement to Ophthalmologists: Years 2012 to 2013.
    Am J Ophthalmol 2017 Oct 4;182:133-140. Epub 2017 Aug 4.
    Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California; Veterans Affairs Palo Alto Health Care System, Palo Alto, California. Electronic address:
    Purpose: To analyze trends in utilization and payment of ophthalmic services in the Medicare population for years 2012 and 2013.

    Design: Retrospective, cross-sectional study.

    Methods: A retrospective cross-sectional observational analysis was performed using publicly available Medicare Physician and Other Supplier aggregate file and the Physician and Other Supplier Public Use File. Read More

    The association between glaucoma, anxiety and depression in a large population.
    Am J Ophthalmol 2017 Jul 28. Epub 2017 Jul 28.
    Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, 5151 Bioinformatics Bldg CB #7040, Chapel Hill, NC 27599. Electronic address:
    Purpose: To investigate the association between glaucoma and each of anxiety and depression.

    Design: Retrospective case-control study.

    Methods: Settings: University of North Carolina hospitals and outpatient clinics. Read More

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