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    39497 results match your criteria American journal of obstetrics and gynecology[Journal]

    1 OF 790

    Emergency in the clinic: A simulation curriculum to improve outpatient safety.
    Am J Obstet Gynecol 2017 Sep 14. Epub 2017 Sep 14.
    University of New Mexico Departments of Family and Community Medicine; Obstetrics and Gynecology, Study conducted in Albuquerque, New Mexico.
    Background: Emergency response skills are essential when events such as seizure, anaphylaxis or hemorrhage occur in the outpatient setting. As services and procedures increasingly move outside the hospital, training to manage complications may improve outcomes.

    Objective: The objective of this study was to evaluate a simulation-based curriculum in outpatient emergency management skills with the outcome measures of graded objective performance and learner self-efficacy. Read More

    Condom Use and Incident Sexually Transmitted Infection after Initiation of Long-Acting Reversible Contraception.
    Am J Obstet Gynecol 2017 Sep 14. Epub 2017 Sep 14.
    Background: Use of more effective contraception may lead to less condom use and increased incidence of sexually transmitted infection.

    Objective: The objective of this study was to compare changes in condom use and incidence of sexually transmitted infection acquisition among new initiators of long-acting reversible contraceptives to those initiating non-long acting reversible contraceptive methods.

    Study Design: This is a secondary analysis of the Contraceptive CHOICE Project. Read More

    Age and fecundability in a North American preconception cohort study.
    Am J Obstet Gynecol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
    Background: There is a well-documented decline in fertility treatment success with increasing female age; however, there are few preconception cohort studies examining female age and natural fertility. In addition, data on male age and fertility is inconsistent. Given the increasing number of couples attempting conception at older ages, a more detailed characterization of age-related fecundability in the general population is of great clinical utility. Read More

    Thyroid stimulating hormone, anti-thyroid antibodies and pregnancy outcomes.
    Am J Obstet Gynecol 2017 Sep 13. Epub 2017 Sep 13.
    Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, 7B03, Rockville, MD, 20852, United States. Electronic address:
    Background: Overt thyroid dysfunction has been associated with adverse obstetrical outcomes. However, less is known regarding subclinical hypothyroidism or thyroid autoimmunity and their relationship to pregnancy complications.

    Objective: To examine the association between pre-pregnancy anti-thyroid antibodies and subclinical hypothyroidism and preterm delivery (PTD), gestational diabetes (GDM), and preeclampsia. Read More

    Management of premature rupture of membranes at term: the need to correct a recurring mistake in articles, chapters, and recommendations of professional organizations.
    Am J Obstet Gynecol 2017 Sep 8. Epub 2017 Sep 8.
    Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:
    Recommendations about the management of premature rupture of membranes at term are based, in part, on a large, randomized controlled trial published in 1996: the TERMPROM trial. The original article contained an error in Table 1, in which "Interval from membrane rupture to delivery" was listed instead of "Interval from membrane rupture to study entry." While the authors and journal corrected this error, the mistake published in the original paper has made its way into subsequent publications and even in guidelines or practice bulletins issued by professional organizations, textbooks, and other publications around the world. Read More

    Nonsteroidal antiinflammatory drug resistance in dysmenorrhea: epidemiology, causes, and treatment.
    Am J Obstet Gynecol 2017 Sep 6. Epub 2017 Sep 6.
    Department of Obstetrics and Gynecology, NorthShore University HealthSystem and Pritzker School of Medicine University of Chicago, Evanston, IL. Electronic address:
    Although nonsteroidal antiinflammatory drugs can alleviate menstrual pain, about 18% of women with dysmenorrhea are unresponsive, leaving them and their physicians to pursue less well-studied strategies. The goal of this review is to provide a background for treating menstrual pain when first-line options fail. Research on menstrual pain and failure of similar drugs in the antiplatelet category suggested potential mechanisms underlying nonsteroidal antiinflammatory drug resistance. Read More

    ASPRE trial: influence of compliance on beneficial effect of aspirin in prevention of preterm preeclampsia.
    Am J Obstet Gynecol 2017 Sep 6. Epub 2017 Sep 6.
    King's College Hospital, London, UK. Electronic address:
    Objective: To examine the influence of compliance on the beneficial effect of aspirin in prevention of preterm preeclampsia in the Combined Multimarker Screening and Randomized Patient Treatment with Aspirin for Evidence-Based Preeclampsia Prevention (ASPRE) trial.

    Study Design: This was a secondary analysis of data from the ASPRE trial. In this multicenter-study women with singleton pregnancies had screening by means of an algorithm that combines maternal factors and biomarkers (mean arterial pressure, uterine-artery pulsatility index, and maternal serum pregnancy-associated plasma protein A and placental growth factor) at 11-13 weeks' gestation. Read More

    Lessons learned from domestic and international human papillomavirus vaccination programs: a review.
    Am J Obstet Gynecol 2017 Sep 6. Epub 2017 Sep 6.
    Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL.
    Since the development of the human papillomavirus vaccine, many countries have created implementation programs to bolster vaccination rates and protect their populations. Despite demonstrated efficacy with decreased human papillomavirus-related disease abroad, the vaccine's potential to prevent morbidity and mortality in the United States is not being met. The purpose of this review is to discuss strategies of both international and domestic vaccination programs, their impact on human papillomavirus-related diseases, the unique obstacles faced by the United States, and future directions for success. Read More

    Food and Drug Administration warning on anesthesia and brain development: implications for obstetric and fetal surgery.
    Am J Obstet Gynecol 2017 Sep 6. Epub 2017 Sep 6.
    Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Texas Children's Fetal Center, Texas Children's Hospital, Houston, TX.
    There has been growing concern about the detrimental effects of certain anesthetic agents on the developing brain. Preclinical studies in small animal models as well as nonhuman primates suggested loss or death of brain cells and consequent impaired neurocognitive function following anesthetic exposure in neonates and late gestation fetuses. Human studies in this area are limited and currently inconclusive. Read More

    A phase-3, double-blind, placebo-controlled study of the effectiveness and safety of single oral doses of secnidazole 2 g for the treatment of women with bacterial vaginosis.
    Am J Obstet Gynecol 2017 Sep 1. Epub 2017 Sep 1.
    Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA.
    Background: A novel single oral dose granule formulation of secnidazole 2 g, a 5-nitroimidazole with a longer half-life (∼17 hours) than metronidazole (∼8 hours), is being developed to treat bacterial vaginosis.

    Objective: We sought to evaluate the effectiveness and safety of single-dose secnidazole 2 g compared to placebo for the treatment of women with bacterial vaginosis.

    Study Design: In all, 189 women with bacterial vaginosis were randomized 2:1 to receive a single oral dose of secnidazole 2 g (N = 125) or matched placebo (N = 64) at 21 centers in the United States. Read More

    Hydralazine vs nifedipine for acute hypertensive emergency in pregnancy: a randomized controlled trial.
    Am J Obstet Gynecol 2017 Sep 1. Epub 2017 Sep 1.
    Dr Rajendra Prasad Government Medical College, Tanda, India.
    Objective: We sought to compare the efficacy of intravenously administered hydralazine and oral nifedipine for acute blood pressure control in acute hypertensive emergency of pregnancy.

    Study Design: In this double-blind, randomized, controlled trial, pregnant women (≥24 weeks POG) with sustained increase in systolic blood pressure of ≥160 mm Hg or diastolic blood pressure of ≥110 mm Hg were randomized to receive intravenous hydralazine injection in doses of 5, 10, 10, and 10 mg and a placebo tablet or oral nifedipine (10 mg tablet up to 4 doses) and intravenous saline injection every 20 minutes until the target blood pressure of 150 mm Hg systolic and ≤100 mm Hg diastolic was achieved. Crossover treatment was administered if the initial treatment failed. Read More

    Trends in contraceptive use according to HIV status among privately insured women in the United States.
    Am J Obstet Gynecol 2017 Sep 1. Epub 2017 Sep 1.
    Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA.
    Background: There is limited information on the patterns and trends of contraceptive use among women living with HIV, compared with noninfected women in the United States. Further, little is known about whether antiretroviral therapy correlates with contraceptive use. Such information is needed to help identify potential gaps in care and to enhance unintended pregnancy prevention efforts. Read More

    Human placentophagy: a review.
    Am J Obstet Gynecol 2017 Aug 30. Epub 2017 Aug 30.
    Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY.
    Placentophagy or placentophagia, the postpartum ingestion of the placenta, is widespread among mammals; however, no contemporary human culture incorporates eating placenta postpartum as part of its traditions. At present, there is an increasing interest in placentophagy among postpartum women, especially in the United States. The placenta can be eaten raw, cooked, roasted, dehydrated, or encapsulated or through smoothies and tinctures. Read More

    Preterm labor in the absence of acute histologic chorioamnionitis is characterized by cellular senescence of the chorioamniotic membranes.
    Am J Obstet Gynecol 2017 Aug 25. Epub 2017 Aug 25.
    Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
    Background: Decidual senescence has been considered a mechanism of disease for spontaneous preterm labor in the absence of severe acute inflammation. Yet, signs of cellular senescence have also been observed in the chorioamniotic membranes from women who underwent the physiological process of labor at term.

    Objective: We aimed to investigate whether, in the absence of acute histologic chorioamnionitis, the chorioamniotic membranes from women who underwent spontaneous preterm labor or labor at term exhibit markers of cellular senescence. Read More

    Pregnant trauma victims experience nearly 2-fold higher mortality compared to their nonpregnant counterparts.
    Am J Obstet Gynecol 2017 Aug 24. Epub 2017 Aug 24.
    Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD; Division of Traumatology, Surgical Critical Care and Emergency Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:
    Background: Trauma is the leading nonobstetric cause of death in women of reproductive age, and pregnant women in particular may be at increased risk of violent trauma. Management of trauma in pregnancy is complicated by altered maternal physiology, provider expertise, potential disparate imaging, and distorted anatomy. Little is known about the impact of trauma on maternal mortality. Read More

    Patient navigation across the spectrum of women's health care in the United States.
    Am J Obstet Gynecol 2017 Aug 24. Epub 2017 Aug 24.
    Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address:
    Patient navigation is a patient-centered intervention that uses trained personnel to identify patient-level barriers, including financial, cultural, logistical, and educational obstacles to health care and then mitigate these barriers to facilitate complete and timely access to health services. For example, to assist a Medicaid patient seeking postpartum care, a patient navigator could help her schedule an appointment before her insurance benefits change, coordinate transportation and child care, give her informational pamphlets on contraception options, and accompany her to the appointment to ensure her questions are answered. Existing studies examining the efficacy of patient navigation interventions show particularly striking benefits in the realm of cancer care, including gynecological oncology; patient navigation has been demonstrated to increase access to screening, shorten time to diagnostic resolution, and improve cancer outcomes, particularly in health disparity populations, such as women of color, rural populations, and poor women. Read More

    All-cause mortality in young women with endometrial cancer receiving progesterone therapy.
    Am J Obstet Gynecol 2017 Aug 24. Epub 2017 Aug 24.
    Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY; Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY; New York Presbyterian Hospital, New York, NY. Electronic address:
    Background: Uterine-preserving therapy with progesterone may be used in young women with endometrial cancer who desire fertility preservation. Such therapy delays definitive treatment with hysterectomy.

    Objective: We examined the use and safety of progestational therapy in young women with endometrial cancer. Read More

    Diet and fertility: a review.
    Am J Obstet Gynecol 2017 Aug 24. Epub 2017 Aug 24.
    Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. Electronic address:
    The literature on the relationship between diet and human fertility has greatly expanded over the last decade, resulting in the identification of a few clear patterns. Intake of supplemental folic acid, particularly at doses higher than those recommended for the prevention of neural tube defects, has been consistently related to lower frequency of infertility, lower risk of pregnancy loss, and greater success in infertility treatment. On the other hand and despite promising evidence from animal models, vitamin D does not appear to exert an important role in human fertility in the absence of deficiency. Read More

    A pilot study in using deep learning to predict limited life expectancy in women with recurrent cervical cancer.
    Am J Obstet Gynecol 2017 Aug 24. Epub 2017 Aug 24.
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA.

    Immediate postpartum levonorgestrel intrauterine device insertion and breast-feeding outcomes: a noninferiority randomized controlled trial.
    Am J Obstet Gynecol 2017 Aug 23. Epub 2017 Aug 23.
    Department of Obstetrics and Gynecology, University of New Mexico School of Medicine, Albuquerque, NM.
    Background: Immediate postpartum levonorgestrel intrauterine device insertion is increasing in frequency in the United States, but few studies have investigated the effect of early placement on breast-feeding outcomes.

    Objective: This study examined the effect of immediate vs delayed postpartum levonorgestrel intrauterine device insertion on breast-feeding outcomes.

    Study Design: We conducted this noninferiority randomized controlled trial at the University of Utah and the University of New Mexico Health Sciences Centers from February 2014 through March 2016. Read More

    Postplacental intrauterine device expulsion by 12 weeks: a prospective cohort study.
    Am J Obstet Gynecol 2017 Aug 19. Epub 2017 Aug 19.
    Department of Obstetrics and Gynecology, Division of Family Planning, University of Colorado School of Medicine, Aurora, CO.
    Background: An intrauterine device placed immediately following a delivery can serve as an effective and safe contraceptive strategy in the postpartum period. There is limited evidence that the levonorgestrel intrauterine system may have a higher rate of expulsion compared to the copper intrauterine device; however, rates of expulsion for these 2 intrauterine device types have not been compared directly.

    Objective: We sought to compare expulsion rates by 12 weeks' postpartum for the levonorgestrel intrauterine system and copper intrauterine device. Read More

    The environmental injustice of beauty: framing chemical exposures from beauty products as a health disparities concern.
    Am J Obstet Gynecol 2017 Aug 16. Epub 2017 Aug 16.
    Urban and Environmental Policy Department, Occidental College, Los Angeles, CA.
    The obstetrics-gynecology community has issued a call to action to prevent toxic environmental chemical exposures and their threats to healthy human reproduction. Recent committee opinions recognize that vulnerable and underserved women may be impacted disproportionately by environmental chemical exposures and recommend that reproductive health professionals champion policies that secure environmental justice. Beauty product use is an understudied source of environmental chemical exposures. Read More

    Ovarian conservation vs removal at the time of benign hysterectomy.
    Am J Obstet Gynecol 2017 Aug 4. Epub 2017 Aug 4.
    Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT.
    Over the last 2 decades, the rate of oophorectomy at the time of hysterectomy in the United States has consistently been between 40-50%. A decline in hormone use has been observed since the release of the principal results of the Women's Health Initiative. Oophorectomy appears to be associated with an increased risk of coronary heart disease, as well as deleterious effects on overall mortality, cognitive functioning, and sexual functioning. Read More

    Influence of paternal age on perinatal outcomes.
    Am J Obstet Gynecol 2017 Aug 4. Epub 2017 Aug 4.
    Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH; Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
    Background: There is an increasing trend to delay childbearing to advanced parental age. Increased risks of advanced maternal age and assisted reproductive technologies are widely accepted. There are limited data regarding advanced paternal age. Read More

    Aspirin for Evidence-Based Preeclampsia Prevention trial: effect of aspirin in prevention of preterm preeclampsia in subgroups of women according to their characteristics and medical and obstetrical history.
    Am J Obstet Gynecol 2017 Aug 4. Epub 2017 Aug 4.
    King's College Hospital, London, United Kingdom. Electronic address:
    Background: The Combined Multimarker Screening and Randomized Patient Treatment with Aspirin for Evidence-Based Preeclampsia Prevention trial demonstrated that in women who were at high risk for preterm preeclampsia with delivery at <37 weeks' gestation identified by screening by means of an algorithm that combines maternal factors and biomarkers at 11-13 weeks' gestation, aspirin administration from 11 to 14 until 36 weeks' gestation was associated with a significant reduction in the incidence of preterm preeclampsia (odds ratio 0.38; 95% confidence interval, 0.20 to 0. Read More

    Social determinants of access to minimally invasive hysterectomy: reevaluating the relationship between race and route of hysterectomy for benign disease.
    Am J Obstet Gynecol 2017 Aug 4. Epub 2017 Aug 4.
    Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
    Background: Racial and socioeconomic disparities exist in access to medical and surgical care. Studies of national databases have demonstrated disparities in route of hysterectomy for benign indications, but have not been able to adjust for patient-level factors that affect surgical decision-making.

    Objective: We sought to determine whether access to minimally invasive hysterectomy for benign indications is differential according to race independent of the effects of relevant subject-level confounding factors. Read More

    Hepatitis C in pregnancy: screening, treatment, and management.
    Am J Obstet Gynecol 2017 Aug 4. Epub 2017 Aug 4.
    In the United States, 1-2.5% of pregnant women are infected with hepatitis C virus, which carries an approximately 5% risk of transmission from mother to infant. Hepatitis C virus can be transmitted to the infant in utero or during the peripartum period, and infection during pregnancy is associated with increased risk of adverse fetal outcomes, including fetal growth restriction and low birthweight. Read More

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