Dilemmas in Genetic Counseling for Low-Penetrance Neuro-Susceptibility Loci Detected on Prenatal Chromosomal Microarray Analysis.
Am J Obstet Gynecol 2017 Nov 13. Epub 2017 Nov 13.
Genetic Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv-Yafo, 6423906, Israel and The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, 6997801, Israel.
Background: Chromosomal microarray analysis is standard of care in fetuses with malformations, detecting clinically significant copy number variants in 5-7% of cases over conventional karyotyping. However, it also detects variants of uncertain significance in 1.6% - 4. Read More