292 results match your criteria American journal of nuclear medicine and molecular imaging[Journal]


Targeting ELTD1, an angiogenesis marker for glioblastoma (GBM), also affects VEGFR2: molecular-targeted MRI assessment.

Am J Nucl Med Mol Imaging 2019 15;9(1):93-109. Epub 2019 Feb 15.

Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation Oklahoma, OK, USA.

Glioblastomas (GBM) are deadly brain tumors that currently do not have long-term patient treatments available. GBM overexpress the angiogenesis factor VEGF and its receptor VEGFR2. ETLD1 (epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1), a G-protein coupled receptor (GPCR) protein, we discovered as a biomarker for high-grade gliomas, is also a novel regulator of angiogenesis. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420708PMC
February 2019

PET/DW-MRI for evaluating treatment in chronic hepatitis C patients.

Am J Nucl Med Mol Imaging 2019 15;9(1):84-92. Epub 2019 Feb 15.

Department of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen Denmark.

This feasibility study set out to investigate the use of FDG-PET/DW-MRI in chronic hepatitis C patients to examine changes in local liver inflammation after treatment with direct-acting antivirals (DAA). Twelve patients with chronic hepatitis C were prospectively enrolled, performing FDG-PET/DW-MRI prior to and after DAA treatment. PET/DW-MRI included PET acquisition 60 and 90 min after FDG-injection, DIXON, for attenuation correction, T2- and DW-MRI with 10 b-values between 0-700 s/mm. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420713PMC
February 2019

Ga[Ga]-, In[In]-oxine: a novel strategy of radiolabeling of HPMA-based micelles.

Am J Nucl Med Mol Imaging 2019 15;9(1):67-83. Epub 2019 Feb 15.

Institute of Nuclear Chemistry, Johannes Gutenberg-University Fritz-Straßmann-Weg 2, Mainz 55128, Germany.

Polymeric micelles are of increasing interest as drug delivery vehicles since they can accumulate in tumor tissue through EPR effect and deliver their hydrophobic cargo. The pharmacology can be visualized and quantified noninvasively by molecular imaging techniques. Here, a novel, fast and efficient technique for radiolabeling various HPMA-LMA based micellar aggregates with hydrophobic oxine-complexes of the trivalent radiometals Ga and In was investigated. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420711PMC
February 2019

Radionuclide generators: the prospect of availing PET radiotracers to meet current clinical needs and future research demands.

Am J Nucl Med Mol Imaging 2019 15;9(1):30-66. Epub 2019 Feb 15.

Radiopharmaceuticals Division, Bhabha Atomic Research Centre Trombay, Mumbai 400085, India.

Targeted molecular imaging with positron emission tomography (PET) constitutes a successful technique for detecting and diagnosing disease conditions promptly and accurately, and for effectively prognosticating outcomes and treating patients with a tailored and more individualized intervention. In order to expand the success of PET in nuclear medicine, it is important to assure access to radiotracers of desired quantities and qualities. In this context, the benefit of accessing PET radiotracers through a radionuclide generator (RNG) cannot be overstated, as generators offer the potential of enriching the PET radiotracer arsenal at the medical centers both with and without onsite cyclotrons. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420712PMC
February 2019
2 Reads

Feasibility of rapid integrated radiation therapy planning with follow-up FDG PET/CT to improve overall treatment assessment in head and neck cancer.

Am J Nucl Med Mol Imaging 2019 15;9(1):24-29. Epub 2019 Feb 15.

Department of Radiation Oncology, University of Colorado School of Medicine Aurora, CO 80045, USA.

Inflammatory changes and residual disease are difficult to distinguish after high dose, definitive radiotherapy of head and neck malignancies. FDG uptake located within a high dose field may more likely represent inflammatory changes, and FDG uptake outside of the radiation field could represent unsuspected and under treated disease. In situ knowledge of the precise radiotherapy fields, therefore, may be useful in distinguishing these etiologies. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420709PMC
February 2019

Diagnostic HER2-binding radiopharmaceutical, [Ga]Ga-ABY-025, for routine clinical use in breast cancer patients.

Am J Nucl Med Mol Imaging 2019 15;9(1):12-23. Epub 2019 Feb 15.

Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University Uppsala, Sweden.

[Ga]Ga-ABY-025/PET-CT targeting human epidermal growth factor receptor type 2 (HER2) has demonstrated its potential clinical value for the detection and quantification of HER2 in a phase I clinical study with breast cancer patients. Previously, the radiopharmaceutical was prepared manually, however larger scale of multicenter clinical trials and routine healthcare requires automation of the production process to limit the operator radiation dose, improve tracer manufacturing robustness, and provide on-line documentation for good manufacturing practice (GMP) compliance. The production of [Ga]Ga-ABY-025 was implemented on the Modular-Lab PharmTrace synthesis platform (Eckert & Ziegler) and disposable cassettes were developed. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420710PMC
February 2019
6 Reads

Tissue volume and activity mapping using total intensity projection of PET/CT images.

Am J Nucl Med Mol Imaging 2019 15;9(1):1-11. Epub 2019 Feb 15.

Department of Nuclear Medicine and PET Center, Aarhus University Hospital Aarhus, Denmark.

Autoradiography using phosphor imaging screens is often used to characterize tissue distribution of positron emission tomography (PET) radiotracers. PET tracers emit positrons with limited penetration range, and valid quantitative autoradiography can therefore only be achieved in thin tissue slices. However, in some settings, quantitative tracer profiling in thick tissues is required. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420714PMC
February 2019

Preclinical PET tracers for the evaluation of sarcomas: understanding tumor biology.

Am J Nucl Med Mol Imaging 2018 20;8(6):428-440. Epub 2018 Dec 20.

Department of Radiology, University of Pennsylvania 3400 Spruce Street, Philadelphia, PA 19104, USA.

Sarcomas are rare tumors of mesenchymal origin. Sarcomas display significant histological heterogeneity, resulting in significant imaging heterogeneity. F-FDG PET has is increasingly used for the evaluation, staging and surveillance of patients with sarcomas. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334210PMC
December 2018

FDG PET imaging in multiple myeloma: implications for response assessments in clinical trials.

Am J Nucl Med Mol Imaging 2018 20;8(6):421-427. Epub 2018 Dec 20.

University Hospitals, Case Comprehensive Cancer Center, Case Western Reserve University Cleveland, OH, USA.

F-fluorodeoxyglucose positron emission tomography integrated with computed tomography (F-FDG PET/CT) is an effective modality to assess disease burden, detect extra-medullary disease and monitor minimal residual disease (MRD) for multiple myeloma (MM) patients. This modality of imaging is incorporated in the International Myeloma Working Group (IMWG) response criteria that are widely used in MM clinical trials. Interpretative pitfalls are commonly encountered in F-FDG PET/CT studies and proper interpretation requires knowledge of the normal physiologic distribution of the tracer affecting available F-FDG for tumor tissue uptake. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334211PMC
December 2018
8 Reads

Utility of metabolic heterogeneity factor in differentiating malignant versus benign parotid uptake on F FDG PET-CT.

Am J Nucl Med Mol Imaging 2018 20;8(6):415-420. Epub 2018 Dec 20.

Department of Nuclear Medicine and PET, John Hunter and Calvary Mater Hospitals Newcastle NSW, Australia.

Differentiation of benign and malignant parotid uptake on Fluorine 18 Fluro-Deoxy-Glucose Positron Emission Tomography-Computed Tomography (F FDG PET-CT) is of paramount importance due to the poor prognosis of the later but usual quantitative measures such as standardized uptake value (SUV) are not reliable for this purpose. Metabolic heterogeneity, being a characteristic of malignant tumors, would potentially be able to make this distinction. In this study, seventy-one FDG-avid parotid lesions were retrospectively separated histologically into benign and malignant groups. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334206PMC
December 2018

Pre-treatment partial-volume-corrected TLG is the best predictor of overall survival in patients with relapsing/refractory non-hodgkin lymphoma following radioimmunotherapy.

Am J Nucl Med Mol Imaging 2018 20;8(6):407-414. Epub 2018 Dec 20.

Department of Radiology, Hospital of The University of Pennsylvania PA, USA.

The role of fluorodeoxyglucose-positron emission tomography (FDG-PET) has been well established in assessment of lymphoma, including non-Hodgkin lymphoma (NHL). The aim of this study was to compare changes and survival predictive values of various quantification parameters of FDG-PET/CT in patients with relapsing/refractory lymphoma before and after radioimmunotherapy (RIT). Data from 17 patients with relapsing/refractory NHL, treated with targeted RIT after chemotherapy/radiotherapy, were retrospectively collected. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334213PMC
December 2018
44 Reads

Evaluation of planar bioluminescence imaging and microPET/CT for therapy monitoring in a mouse model of pigmented metastatic melanoma.

Am J Nucl Med Mol Imaging 2018 20;8(6):397-406. Epub 2018 Dec 20.

Unité Claude Kellershohn, Institut Universitaire d'Hématologie, Hôpital St-Louis Paris, France.

Bioluminescence imaging (BLI) is widely used for monitoring of anti-cancer therapy in mice. [F]MEL050 is a Positron Emission Tomography (PET) radiotracer which specifically targets melanin. We evaluated planar BLI and [F]MEL050-PET/CT for therapy (pro-apoptotic peptide LZDP) monitoring in a mouse model of metastatic pigmented melanoma. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334212PMC
December 2018
2 Reads

Metabolic and densitometric correlation between atherosclerotic plaque and trabecular bone: an F-Natrium-Fluoride PET/CT study.

Am J Nucl Med Mol Imaging 2018 20;8(6):387-396. Epub 2018 Dec 20.

Nuclear Medicine Unit, Department of Health Sciences, University of Genoa Italy.

Increasing evidence links atherosclerosis to a decreased bone thickness. This correlation could reflect a bone/plaque interaction. Hereby we analyzed Hounsfield density (HU) and mineral turnover in bone and in the arterial calcifications (AC), using a computational method applied to PET/CT data. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334207PMC
December 2018

Multi-level otsu method to define metabolic tumor volume in positron emission tomography.

Am J Nucl Med Mol Imaging 2018 20;8(6):373-386. Epub 2018 Dec 20.

Radiology, University of Wisconsin Madison, WI, USA.

This study was to validate reliability and clinical utility of a PET tumor segmentation method using multi-level Otsu (MO-PET) in standard National Electrical Manufacturers Association (NEMA) image quality (IQ) phantom and patients with osteosarcoma. The NEMA IQ phantom was prepared with a lesion-to-background ratio (LBR) of either 8:1, 4:1, or 1.5:1. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334209PMC
December 2018
8 Reads

Early perfusion and dopamine transporter imaging using F-FP-CIT PET/CT in patients with parkinsonism.

Am J Nucl Med Mol Imaging 2018 20;8(6):360-372. Epub 2018 Dec 20.

Department of Nuclear Medicine, Kyungpook National University Hospital Daegu, Republic of Korea.

Combined use of F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl)nortropane (FP-CIT) for dopamine transporter imaging and F-fludeoxyglucose (FDG) for glucose metabolism shows good diagnostic performance for differential diagnosis of Parkinson disease (PD) and Parkinson plus syndrome (multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies). A recent study showed that F-FP-CIT positron emission tomography (PET) with early perfusion imaging is useful for the differential diagnosis of PD and Parkinson plus syndrome with lower radiation exposure, time, and cost. In this review, we summarize the advantages of using F-FP-CIT PET for perfusion and dopamine transporter imaging, as well as clinical features useful for the differential diagnosis of PD and Parkinson plus syndrome. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334208PMC
December 2018
2 Reads

Ga-PSMA-11 PET/CT in prostate cancer local recurrence: impact of early images and parametric analysis.

Am J Nucl Med Mol Imaging 2018 20;8(5):351-359. Epub 2018 Oct 20.

Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ) Heidelberg, Germany.

Ga-PSMA-11 PET/CT performed 60 min post tracer injection (p.i.) can underestimate prostate cancer (PC) local recurrence, due to high Ga-PSMA-11 urinary bladder accumulation. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261880PMC
October 2018
2 Reads

Usefulness of positron emission mammography in the evaluation of response to neoadjuvant chemotherapy in patients with breast cancer.

Am J Nucl Med Mol Imaging 2018 20;8(5):341-350. Epub 2018 Oct 20.

Human Health Department International Atomic Energy Agency (IAEA).

Our study examines the association between two Positron Emission Mammography (PEM) semi-quantitative parameters: PUVmax (maximum uptake value) and LTB (lesion to background) baseline and the end of Neoadjuvant chemotherapy (NAC) with pathologic response in each of the following breast cancer subtype: Triple negative breast cancer (TPN), HER2-positive, and ER-positive/HER2-negative cancers. One-hundred and eight patients, 71 with invasive ductal carcinoma and 37 with infiltrating lobular carcinoma were evaluate with F-FDG-PEM scans before and after of NAC. We assessed the impact of 2 PEM semi-quantitative parameters for molecular subtype correlated with pathologic response according Miller-Payne grade (MPG). Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261879PMC
October 2018
1 Read

Head to head comparison performance of Tc-EDDA/HYNIC-iPSMA SPECT/CT and Ga-PSMA-11 PET/CT a prospective study in biochemical recurrence prostate cancer patients.

Am J Nucl Med Mol Imaging 2018 20;8(5):332-340. Epub 2018 Oct 20.

Nuclear Medicine and Department of Molecular Imaging, Instituto Nacional de Cancerología Mexico City, Mexico.

Positron emission tomography (PET) with prostate-specific membrane antigen (PSMA) has found widespread use for the diagnosis of biochemical recurrence of prostate cancer (PCa). Unfortunately, PET/CT is not as widely available; thus a PSMA-targeting compound for scintigraphy is of special interest. The aim of this study was to compare Tc-EDDA/HYNIC-iPSMA and Ga-PSMA-11 PET/CT qualitatively and semi-quantitatively. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261875PMC
October 2018
14 Reads

Somatostatin receptor PET ligands - the next generation for clinical practice.

Am J Nucl Med Mol Imaging 2018 20;8(5):311-331. Epub 2018 Oct 20.

Nuclear Medicine, University Hospitals Leuven Leuven, Belgium.

Somatostatin receptors (SSTRs) are variably expressed by a variety of malignancies. Using radiolabeled somatostatin analogs (SSAs), the presence of SSTRs on tumor cells may be exploited for molecular imaging and for peptide receptor radionuclide therapy. In-DTPA-octreotide has long been the standard in SSTR scintigraphy. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261874PMC
October 2018
1 Read

Chemotherapy-induced coronary arteries calcium score deterioration as detected with unenhanced CT portion of FDG PET/CT.

Am J Nucl Med Mol Imaging 2018 20;8(5):303-310. Epub 2018 Oct 20.

Division of Nuclear Medicine, Department of Radiology, Saint Louis University 3635 Vista Ave, Saint Louis, MO 63110, USA.

This study aims to detect the potential impact of chemotherapy on the coronary calcium scoring (CCS) in lymphoma patients undergoing FDG-PET/CT at baseline and for therapy response using the CT portion of the exam to calculate the CCS. One hundred twelve lymphoma patients were included in the study based on having both baseline and at least 2 post-chemotherapy scans. The unenhanced CT portions of the scans were reviewed to measure the CCS which was then extracted using the Toshiba Vital Program. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261876PMC
October 2018
18 Reads

Non-invasive quantification of tumor blood flow in prostate cancer using O-HO PET/CT.

Am J Nucl Med Mol Imaging 2018 20;8(5):292-302. Epub 2018 Oct 20.

Department of Nuclear Medicine and PET Centre, Aarhus University Hospital Aarhus C, Denmark.

Tumor blood flow (TBF) measurements in prostate cancer (PCa) provide an integrative index of tumor growth, which could be important for primary diagnosis and therapy response evaluation. O-water PET is the non-invasive gold standard but is technically demanding. The aim of this study was to compare the accuracy of three different non-invasive strategies with an invasively measured arterial input function (BSIF): Using image-derived input functions (IDIF) from either 1) a separate heart scan or 2) the pelvic scan or 3) a populations-based input function (PBIF). Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261877PMC
October 2018
7 Reads

A dual-labeled cRGD-based PET/optical tracer for pre-operative staging and intraoperative treatment of colorectal cancer.

Am J Nucl Med Mol Imaging 2018 20;8(5):282-291. Epub 2018 Oct 20.

Department of Surgery, Leiden University Medical Center Leiden, The Netherlands.

cRGD peptides target integrins associated with angiogenesis (e.g., αβ) and cancer, and have been used as binding ligands for both positron emission tomography (PET) and near-infrared fluorescence (NIRF) optical imaging. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261878PMC
October 2018
3 Reads

F-labeled radiopharmaceuticals for the molecular neuroimaging of amyloid plaques in Alzheimer's disease.

Am J Nucl Med Mol Imaging 2018 20;8(4):268-281. Epub 2018 Aug 20.

Department of Biomedicine and Prevention, University Tor Vergata Rome, Italy.

Alzheimer's disease (AD) is the most common cause of dementia in the elderly, with tremendous impact on the affected individuals and the society. Definitive diagnosis can be achieved only by post mortem examination. Clinical diagnosis criteria currently applied in clinical practice for AD often fail to accurately discriminate between AD and non-AD dementia with up to 40% of misdiagnosed patients. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146162PMC
August 2018
17 Reads

Targeted α-therapy of prostate cancer using radiolabeled PSMA inhibitors: a game changer in nuclear medicine.

Am J Nucl Med Mol Imaging 2018 20;8(4):247-267. Epub 2018 Aug 20.

Department of Radiology, University of Wisconsin-Madison WI 53792-3252, USA.

Prostate cancer (PCa) is one of the most common malignancies in men and is a major contributor to cancer related deaths worldwide. Metastatic spread and disease progression under androgen deprivation therapy signify the onset of metastatic castration resistant prostate cancer (mCRPCa)-the lethal form of the disease, which severely deteriorates the quality of life of patients. Over the last decade, tremendous progress has been made toward identifying appropriate molecular targets that could enable efficient targeting for non-invasive imaging and therapy of mCPRCa. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146164PMC
August 2018
2 Reads

Z-score maps from low-dose F-FDG PET of the brain in neurodegenerative dementia.

Am J Nucl Med Mol Imaging 2018 20;8(4):239-246. Epub 2018 Aug 20.

Department of Surgical Sciences, Nuclear Medicine and PET, Uppsala University Uppsala, Sweden.

Neuroimaging is a central part of diagnostic work-up of patients with suspected neurodegenerative disease. FDG-PET can reveal pathological changes earlier and more reliably than morphological imaging. Diagnostic accuracy can be improved by constructing 3D SSP Z-score maps, showing patterns of significant deficits. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146163PMC

Hepato-splenic axis: hepatic and splenic metabolic activities are linked.

Am J Nucl Med Mol Imaging 2018 5;8(3):228-238. Epub 2018 Jun 5.

Clinical Imaging Sciences Centre, Brighton Sussex Medical School Brighton, UK.

The concept of a hepato-splenic axis has recently been put forward. We aimed to investigate whether hepatic and splenic metabolic activities are linked, and if splenic metabolic activity is increased in non-alcoholic fatty liver disease (NAFLD). Blood clearance rates of phosphorylated F-fluorodeoxyglucose were measured in the spleen and liver from dynamic PET using Gjedde-Patlak-Rutland graphical analysis and abdominal aorta for input function in 59 patients undergoing routine PET/CT. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056241PMC
June 2018
1 Read

Searching for novel PET radiotracers: imaging cardiac perfusion, metabolism and inflammation.

Am J Nucl Med Mol Imaging 2018 5;8(3):200-227. Epub 2018 Jun 5.

Department of Biology, Lakehead University Thunder Bay, Ontario, Canada.

Advances in medical imaging technology have led to an increased demand for radiopharmaceuticals for early and accurate diagnosis of cardiac function and diseased states. Myocardial perfusion, metabolism, and hypoxia positron emission tomography (PET) imaging radiotracers for detection of cardiac disease lack specificity for targeting inflammation that can be an early indicator of cardiac disease. Inflammation can occur at all stages of cardiac disease and currently, F-fluorodeoxyglucose (FDG), a glucose analog, is the standard for detecting myocardial inflammation. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056242PMC

Multimodal imaging provides insight into targeted therapy response in metastatic prostate cancer to the bone.

Am J Nucl Med Mol Imaging 2018 5;8(3):189-199. Epub 2018 Jun 5.

Department of Radiology, University of Michigan Ann Arbor, Michigan, United States of America.

Metastatic prostate cancer to bone remains incurable, driving efforts to develop individualized, targeted therapies to improve clinical outcomes while limiting adverse side-effects. Due to the complexity in cellular signaling pathways and the interaction between cancer and its microenvironment, multiparametric imaging approaches for treatment response may improve understanding of the biological effects of therapy. An orthotopic model of castration resistant prostate cancer (CRPC) bone metastasis was treated with the tyrosine kinase inhibitor Cabozantinib (CABO). Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056245PMC

X-ray fluorescence imaging of metals and metalloids in biological systems.

Am J Nucl Med Mol Imaging 2018 5;8(3):169-188. Epub 2018 Jun 5.

Australian Institute for Bioengineering and Nanotechnology, The University of Queensland St Lucia, QLD 4072, Australia.

Metals and metalloids play fundamental roles in many physiological processes in biological systems, but imbalance of these elements in the body may cause many diseases, such as Parkinson's disease, Alzheimer's disease, and even cancers. Thus, to better understand the metallome in health and disease, quantitative determination of their localization, concentration, speciation, and related metabolism at cellular or subcellular levels is of great importance. X-ray fluorescence (XRF) imaging, as a new generation of analytical technique, has been reported as an ideal tool to quantitatively map multiple metals and metalloids in tissues with reasonable sensitivity, specificity, and resolution. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056246PMC
June 2018
1 Read

Accuracy of whole-body HDP SPECT/CT, FDG PET/CT, and their combination for detecting bone metastases in breast cancer: an intra-personal comparison.

Am J Nucl Med Mol Imaging 2018 5;8(3):159-168. Epub 2018 Jun 5.

Department of Nuclear Medicine, Geneva University and University Hospitals of Geneva Rue Gabrielle-Perret-Gentil, 4, CH-1211 Geneva, Switzerland.

New generation SPECT/CT scanners allow rapid whole-body imaging, and potentially facilitate significantly improved diagnostic accuracy. Thus, the aim of this study was to compare the diagnostic accuracy of whole-body Tc-99m-HDP SPECT/CT, F-18-FDG PET/CT, and their combination for detecting bone metastases in breast cancer. Women with biopsy-proven breast cancer that were referred for whole-body SPECT/CT and FDG PET/CT were consecutively included in this retrospective study. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056244PMC
June 2018
1 Read

Awake tracheal intubation using combination of an Airtraq optical laryngoscope with smartphone and video flexible endoscope: a case report.

Am J Nucl Med Mol Imaging 2018 5;8(3):153-158. Epub 2018 Jun 5.

Department of Anesthesiology and Pain Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, PR China.

A patient with obvious difficult airway who was received awake tracheal intubation using combination of an Airtraq optical laryngoscope with smartphone and video flexible endoscope posted for elective surgery of tonsillectomy for OSAHS was reported. Our experiences strongly indicate that fully communication with patients, detailed preoperative assessment of airways and perfect plan, appropriate endotracheal intubation approach and devices play important roles in awake tracheal intubation in difficult airway. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056243PMC
June 2018
1 Read

CT dose modulation using automatic exposure control in whole-body PET/CT: effects of scout imaging direction and arm positioning.

Am J Nucl Med Mol Imaging 2018 25;8(2):143-152. Epub 2018 Apr 25.

Department of Radiology, Kitasato University Hospital Sagamihara, Japan.

Automatic exposure control (AEC) modulates tube current and consequently X-ray exposure in CT. We investigated the behavior of AEC systems in whole-body PET/CT. CT images of a whole-body phantom were acquired using AEC on two scanners from different manufactures. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944830PMC
April 2018
2 Reads

F-FDG PET/CT findings in hepatosplenic Gamma-Delta T-cell lymphoma: case reports and review of the literature.

Am J Nucl Med Mol Imaging 2018 25;8(2):137-142. Epub 2018 Apr 25.

Department of Radiology, University of Colorado Aurora, Colorado, USA.

Hepatosplenic Gamma Delta T cell lymphoma (γδHSTL) is a rare, highly aggressive, and rapidly lethal T cell lymphoma which manifests F-FDG PET/CT findings that can mimic benign conditions. Patients with γδHSTL present with unexplained symptoms of a hematologic malignancy like the B symptoms of lymphoma including weight loss, fevers, and night sweats, as well as, splenomegaly and hepatomegaly. Thrombocytopenia, anemia, or neutropenia are also common due to spleen, liver and bone marrow involvement. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944829PMC
April 2018
3 Reads

Repeatability of FDG PET/CT metrics assessed in free breathing and deep inspiration breath hold in lung cancer patients.

Am J Nucl Med Mol Imaging 2018 25;8(2):127-136. Epub 2018 Apr 25.

Division of Biostatistics and Bioinformatics, University of Maryland Greenebaum Comprehensive Cancer Center MD 21201, Baltimore, USA.

We measured the repeatability of FDG PET/CT uptake metrics when acquiring scans in free breathing (FB) conditions compared with deep inspiration breath hold (DIBH) for locally advanced lung cancer. Twenty patients were enrolled in this prospective study. Two FDG PET/CT scans per patient were conducted few days apart and in two breathing conditions (FB and DIBH). Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944828PMC

Determination of binding affinity of molecular imaging agents for steroid hormone receptors in breast cancer.

Am J Nucl Med Mol Imaging 2018 25;8(2):119-126. Epub 2018 Apr 25.

Department of Radiology, University of Wisconsin School of Medicine and Public Health 600 Highland Avenue, Madison, WI 53792, USA.

16α-[F]Fluoro-17β-estradiol ([F]FES) and 21-[F]-Fluoro-16α,17α-[(R)-(1'-α-furylmethylidene)dioxyl]-19-norpregn-4-ene-3,20-dione ([F]FFNP) are being investigated as imaging biomarkers for breast cancer patients. Quantitative positron emission tomography (PET) reflects both total receptor content and binding affinity. To study factors that may alter radiopharmaceutical binding and impact PET accuracy, assays that can separate receptor amount from binding affinity are needed. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944827PMC
April 2018
5 Reads

Standard OSEM vs. regularized PET image reconstruction: qualitative and quantitative comparison using phantom data and various clinical radiopharmaceuticals.

Am J Nucl Med Mol Imaging 2018 25;8(2):110-118. Epub 2018 Apr 25.

Department of Radiology, Stanford University Stanford 94305, CA, USA.

We investigated the block sequential regularized expectation maximization (BSREM) algorithm. ACR phantom measurements with different count statistics and 60 PET/CT research scans from the GE Discovery 600 and 690 scanners were reconstructed using BSREM and the standard-of-care OSEM algorithm. Hot concentration recovery and cold contrast recovery were measured from the phantom data. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944826PMC
April 2018
1 Read

FDG PET-CT SUVmax and IASLC/ATS/ERS histologic classification: a new profile of lung adenocarcinoma with prognostic value.

Am J Nucl Med Mol Imaging 2018 25;8(2):100-109. Epub 2018 Apr 25.

Department of Pathology, Hospital del Mar, IMIM Barcelona, Spain.

Quantitative analysis of glucose consumption measured by maximum standardized uptake value (SUVmax) in lung adenocarcinoma (LA) remains in discussion and metabolic information provided by FDG-PET is not included in cancer staging. The first aim of this work was to evaluate the correlation between SUVmax and different histologic subtypes of LA. The second aim was to establish the correlation between SUVmax and TNM, genetic mutations and prognostic. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944825PMC
April 2018
4 Reads

Lipopolysaccharide endotoxemia induces amyloid-β and p-tau formation in the rat brain.

Am J Nucl Med Mol Imaging 2018 25;8(2):86-99. Epub 2018 Apr 25.

Department of Radiology and Imaging Sciences, University of Utah Salt Lake City, UT, USA.

Amyloid beta (Aβ) plaques are not specific to Alzheimer's disease and occur with aging and neurodegenerative disorders. Soluble brain Aβ may be neuroprotective and increases in response to neuroinflammation. Sepsis is associated with neurocognitive compromise. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944824PMC
April 2018
7 Reads

Quantitative PET of liver functions.

Am J Nucl Med Mol Imaging 2018 25;8(2):73-85. Epub 2018 Apr 25.

Department of Nuclear Medicine and PET Centre, Aarhus University Hospital Aarhus, Denmark.

Improved understanding of liver physiology and pathophysiology is urgently needed to assist the choice of new and upcoming therapeutic modalities for patients with liver diseases. In this review, we focus on functional PET of the liver: 1) Dynamic PET with 2-deoxy-2-[F]fluoro--galactose (F-FDGal) provides quantitative images of the hepatic metabolic clearance (mL blood/min/mL liver tissue) of regional and whole-liver hepatic metabolic function. Standard-uptake-value () from a static liver F-FDGal PET/CT scan can replace and is currently used clinically. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944823PMC
April 2018
2 Reads

Diagnostic performance of PET/MR in the evaluation of active inflammation in Crohn disease.

Am J Nucl Med Mol Imaging 2018 5;8(1):62-69. Epub 2018 Feb 5.

Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School149 13th Street Charlestown #2301, Boston 02129, MA, USA.

This study investigates the performance of PET/MR versus each sub-modality alone in the assessment of active inflammation in patients with Crohn disease, when compared to surgery as standard of reference. Sensitivity for detecting active inflammation was 91.5% for PET, 80% for MR, and 88% for PET/MR. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840324PMC
February 2018
5 Reads

Assessment of very early response evaluation with F-FDG-PET/CT predicts survival in erlotinib treated NSCLC patients-A comparison of methods.

Am J Nucl Med Mol Imaging 2018 5;8(1):50-61. Epub 2018 Feb 5.

Department of Oncology, Aarhus University HospitalAarhus, Denmark.

We evaluated whether changes in F-Fluoro-D-Glucose (F-FDG)-uptake evaluated early during erlotinib treatment predict survival in non-small cell lung cancer (NSCLC) patients. Positron emission tomography (PET)/CT scans from 56 NSCLC patients before and after 7-10 days of erlotinib treatment were analyzed with four different methods: Visual evaluation and percentage change in lean body mass corrected standardized uptake values (SULs): SUL, SUL and total lesion glycolysis (TLG). The semi-quantitative parameters abilities to predict progression free survival (PFS) and overall survival (OS) were compared and we found that percentage change in SUL, SUL and TLG all correlated with PFS and OS with the strongest correlation found for TLG (R=0. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840323PMC
February 2018
5 Reads

Thalamic and basal ganglia metabolism on interictal F-FDG PET in temporal lobe epilepsy: an SUV-based analysis.

Am J Nucl Med Mol Imaging 2018 5;8(1):41-49. Epub 2018 Feb 5.

Division of Nuclear Medicine, Department of Radiology, University of Wisconsin School of Medicine and Public HealthMadison, WI, USA.

The aim of this study was to investigate thalamic and basal ganglia (BG) metabolism in temporal lobe epilepsy (TLE) on interictal F-FDG PET using standardized uptake value (SUV). Retrospective review of data was undertaken for patients who were surgically treated for medically intractable TLE. All patients underwent F-FDG PET, MRI brain and EEG as preoperative workup, and subsequently underwent temporal lobe resection. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840322PMC
February 2018
4 Reads

Synthesis, radiolabelling, and evaluation of [C]PB212 as a radioligand for imaging sigma-1 receptors using PET.

Am J Nucl Med Mol Imaging 2018 5;8(1):32-40. Epub 2018 Feb 5.

Department of Chemistry and Applied Biosciences, Center for Radiopharmaceutical Sciences of ETH-PSI-USZ, Institute of Pharmaceutical Sciences, ETH ZurichCH-8093, Zurich, Switzerland.

The Sigma-1 receptor (Sig-1R) has been described as a of distinct physiological functions and its involvement in various central and peripheral pathological disorders has been demonstrated. However, further investigations are required to understand the complex role of the Sig-1R as a molecular chaperon. A specific PET radioligand would provide a powerful tool in Sig-1R related studies. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840321PMC
February 2018
1 Read

Preparation and evaluation of a Ga-labeled RGD-containing octapeptide for noninvasive imaging of angiogenesis: biodistribution in non-human primate.

Am J Nucl Med Mol Imaging 2018 5;8(1):15-31. Epub 2018 Feb 5.

Uppsala Imanet, GE HealthcareSE-75109, Uppsala, Sweden.

Monitoring general disease marker such as angiogenesis may contribute to the development of personalized medicine and improve therapy outcome. Readily availability of positron emitter based imaging agents providing quantification would expand clinical positron emission tomography (PET) applications. Generator produced Ga provides PET images of high resolution and the half-life time frame is compatible with the pharmacokinetics of small peptides comprising arginine-glycine-aspartic acid (RGD) sequence specific to αβ integrin receptors. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840320PMC
February 2018
3 Reads

Adenoid cystic carcinoma: focus on heavy ion therapy and molecular imaging.

Am J Nucl Med Mol Imaging 2018 5;8(1):1-14. Epub 2018 Feb 5.

Department of Nuclear Medicine, Humanitas Clinical and Research HospitalRozzano 20089, Italy.

Surgery, radiation therapy and chemotherapy are the oldest modalities for cancer treatment. However, as part of a continuous research in medicine, in order to improve therapeutic precision and biological effectiveness, there is an increasing interest into the use of heavy particle (e.g. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840319PMC
February 2018
1 Read

Sparse domain approaches in dynamic SPECT imaging with high-performance computing.

Am J Nucl Med Mol Imaging 2017 20;7(6):283-294. Epub 2017 Dec 20.

Department of Radiology and Biomedical Imaging, University of CaliforniaSan Francisco, CA 94143, USA.

Iterative reconstruction algorithms often have relatively large computation time affecting their clinical deployment. This is especially true for 4D reconstruction in dynamic imaging (DI). In this work, we have shown how sparse domain approaches and parallelization for static 3D image reconstruction and 4D dynamic image reconstruction (directly from sinogram) in Single Photon Emission Computed Tomography (SPECT), without any intermediate 3D reconstructions, can improve computational efficiency. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768923PMC
December 2017
3 Reads

Pictorial atlas of symptomatic accessory ossicles by F-Sodium Fluoride (NaF) PET-CT.

Am J Nucl Med Mol Imaging 2017 20;7(6):275-282. Epub 2017 Dec 20.

Jaber Al-Ahmad Molecular Imaging CenterKuwait.

Accessory ossicles are developmental variants which are often asymptomatic. When incidentally picked up on imaging, they are often inconsequential and rarely a cause for concern. However, they may cause pain or discomfort due to trauma, altered stress, and over-activity. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768922PMC
December 2017
2 Reads

Development of a clinically feasible [C]PE2I PET method for differential diagnosis of parkinsonism using reduced scan duration and automated reference region extraction.

Am J Nucl Med Mol Imaging 2017 20;7(6):263-274. Epub 2017 Dec 20.

Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala UniversityUppsala, Sweden.

[C]PE2I is a highly selective dopamine transporter PET ligand. Parametric images based on dynamic [C]PE2I scans, showing dopamine transporter availability (BP) and relative cerebral blood flow (R), can be used in differential diagnosis of parkinsonism. This work aimed to investigate a shortened scan duration and automated generation of parametric images which are two prerequisites for routine clinical application. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768921PMC
December 2017
2 Reads

The value of FDG PET/CT for follow-up of patients with melanoma: a retrospective analysis.

Am J Nucl Med Mol Imaging 2017 20;7(6):255-262. Epub 2017 Dec 20.

Department of Clinical Physiology, Nuclear Medicine and PET Rigshospitalet, University of CopenhagenDenmark.

The incidence of melanoma (MM) is among the fastest rising cancers in the western countries. Positron Emission Tomography with Computed Tomography (PET/CT) is a valuable non-invasive tool for the diagnosis and staging of patients with MM. However, research on the value of PET/CT in follow-up of melanoma patients is limited. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768920PMC
December 2017
2 Reads