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    3769 results match your criteria American journal of nephrology[Journal]

    1 OF 76

    Deterioration of Cortical Bone Microarchitecture: Critical Component of Renal Osteodystrophy Evaluation.
    Am J Nephrol 2018 May 23;47(6):376-384. Epub 2018 May 23.
    Osteoporosis and Bone Biology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
    Background: Cortical bone is a significant determinant of bone strength and its deterioration contributes to bone fragility. Thin cortices and increased cortical porosity have been noted in patients with chronic kidney disease (CKD), but the "Turnover Mineralization Volume" classification of renal osteodystrophy does not emphasize cortical bone as a key parameter. We aimed to assess trabecular and cortical bone microarchitecture by histomorphometry and micro-CT in patients with CKD G5 and 5D (dialysis). Read More

    Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study.
    Am J Nephrol 2018 May 18;47(5):304-316. Epub 2018 May 18.
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    Background: Chronic kidney disease (CKD) is a rapidly growing, worldwide public health problem. Recent advances in genome-wide-association studies (GWAS) revealed several genetic loci associated with renal function traits worldwide.

    Methods: We investigated the association of genetic factors with the levels of serum creatinine (SCr) and the estimated glomerular filtration rate (eGFR) in Japanese population-based cohorts analyzing the GWAS imputed data with 11,221 subjects and 12,617,569 variants, and replicated the findings with the 148,829 hospital-based Japanese subjects. Read More

    Kidney Disease in Women is Associated with Disadvantaged Childhood Socioeconomic Position.
    Am J Nephrol 2018 May 18;47(5):292-299. Epub 2018 May 18.
    The Irish Longitudinal Study on Ageing, Trinity College Dublin, Dublin, Ireland.
    Background: Socioeconomic position (SEP) is an important determinant of health and it is dynamic across the entire lifespan. We sought to investigate the relationship between life-course SEP and chronic kidney disease (CKD) using 3 conceptual models: critical period, pathway and accumulation.

    Methods: Cross-sectional analysis of 4,996 participants from The Irish Longitudinal Study on Ageing, a nationally representative cohort of community-dwelling adults aged ≥50 years. Read More

    High Intraperitoneal Interleukin-6 Levels Predict Peritonitis in Peritoneal Dialysis Patients: A Prospective Cohort Study.
    Am J Nephrol 2018 May 18;47(5):317-324. Epub 2018 May 18.
    Background: To evaluate the predictive value of dialysate interleukin-6 (IL-6) representing local subclinical intraperitoneal inflammation for the development of peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients.

    Methods: Stable prevalent CAPD patients were enrolled in this prospective study. IL-6 concentration in the overnight effluent was determined and expressed as the IL-6 appearance rate (IL-6AR). Read More

    Low Plasma Hydrogen Sulfide Is Associated with Impaired Renal Function and Cardiac Dysfunction.
    Am J Nephrol 2018 May 18;47(5):361-371. Epub 2018 May 18.
    Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
    Background: Chronic kidney disease (CKD) has been proposed to associate with decreased hydrogen sulfide (H2S) level. Nevertheless, the role of H2S in the pathogenesis of CKD has not been fully investigated. Our study aimed to investigate the plasma level of endogenous H2S in patients with different stages of CKD, and to identify the role of H2S in the progression of CKD and its relationship with cardiovascular diseases. Read More

    Dietary Changes Involving Bifidobacterium longum and Other Nutrients Delays Chronic Kidney Disease Progression.
    Am J Nephrol 2018 May 18;47(5):325-332. Epub 2018 May 18.
    Department of Nephrology, Wakayama Medical University, Wakayama, Japan.
    Background: Recent studies suggest that prebiotic and/or probiotic treatments ameliorate kidney function in humans and animals by improving the gut environment. However, the gut microbiota and kidney disease interactions remain to be determined. This study investigated whether synbiotics modulate the gut microbiota and ameliorate kidney function using a rat model of chronic kidney disease (CKD). Read More

    Association of Pre-End-Stage Renal Disease Hemoglobin with Early Dialysis Outcomes.
    Am J Nephrol 2018 May 18;47(5):333-342. Epub 2018 May 18.
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine, School of Medicine, Orange, California, USA.
    Background: Incident hemodialysis patients have a high mortality risk within the first months after dialysis initiation. Pre-end-stage renal disease (ESRD) factors like anemia management may impact early post-ESRD outcomes. Therefore, we evaluated the impact of pre-ESRD hemoglobin (Hgb) and pre-ESRD Hgb slope on post-ESRD mortality and hospitalization outcomes. Read More

    Uromodulin mRNA from Urinary Extracellular Vesicles Correlate to Kidney Function Decline in Type 2 Diabetes Mellitus.
    Am J Nephrol 2018 May 18;47(5):283-291. Epub 2018 May 18.
    Department of Medicine, Section of Nephrology, Veterans Administration San Diego Healthcare System, San Diego, California, USA.
    Background: Extracellular vesicles (EVs) enclose mRNA derived from their cell of origin and are considered a source of potential biomarkers. We examined urinary EV mRNA from individuals with diabetic kidney disease (DKD), chronic kidney disease, type 2 diabetes (T2DM), and obese and healthy controls to determine if such biomarkers had the potential to classify kidney disease and predict patients at higher risk of renal function decline.

    Methods: A total of 242 participants enrolled in this study. Read More

    Differential Determinants of Tubular Phosphate Reabsorption: Insights on Renal Excretion of Phosphates in Kidney Disease.
    Am J Nephrol 2018 May 18;47(5):300-303. Epub 2018 May 18.
    Department of Nephrology, CH Boulogne-sur-Mer, Boulogne-sur-Mer, France.
    We assessed the tubular reabsorption of phosphate (TRP) and maximal renal threshold for phosphate reabsorption to glomerular filtration rate (TmPi/GFR) and their determinants in 64 stages 2-4 chronic kidney disease (CKD) patients in order to define the early changes in phosphate metabolism in CKD. In multivariable analysis, TmPi/GFR correlates were estimated GFR (eGFR), intact parathyroid hormone (iPTH), and hemoglobin (R2 = 0.417), while TRP correlates were eGFR, iPTH, 24-h phosphaturia, and calcitriol (R2 = 0. Read More

    A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease.
    Am J Nephrol 2018 May 18;47(5):352-360. Epub 2018 May 18.
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
    Background: Metformin inhibits cyclic AMP generation and activates AMP-activated protein kinase (AMPK), which inhibits the cystic fibrosis transmembrane conductance regulator and Mammalian Target of Rapamycin pathways. Together these effects may reduce cyst growth in autosomal dominant polycystic kidney disease (ADPKD).

    Methods: A phase II, double-blinded randomized placebo-controlled trial of 26 months duration. Read More

    Parathyroid Hormone, Fibroblast Growth Factor 23, and Parameters of Phosphate Reabsorption.
    Am J Nephrol 2018 May 18;47(5):343-351. Epub 2018 May 18.
    Methodist South Hospital, Memphis, Tennessee, USA.
    Background: The serum phosphorus concentration ([P]s) is the sum of EP/Ccr and TRP/Ccr, where Ccr is creatinine clearance and EP and TRP are rates of excretion and reabsorption of phosphate. In chronic kidney disease (CKD), parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) mediate reduction of TRP/Ccr, and [PTH] and [FGF23] are linear functions of EP/Ccr. If controls and patients with CKD are considered together, TRP/Ccr is a hyperbolic function of EP/Ccr. Read More

    Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure.
    Am J Nephrol 2018 26;47(4):275-282. Epub 2018 Apr 26.
    Department of Family Medicine, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
    Background: Uromodulin is a kidney-derived glycoprotein and putative tubular function index. Lower serum uromodulin was recently associated with increased risk for kidney allograft failure in a preliminary, longitudinal single-center -European study involving 91 kidney transplant recipients (KTRs).

    Methods: The Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) trial is a completed, large, multiethnic controlled clinical trial cohort, which studied chronic, stable KTRs. Read More

    Response Predictors to Calcineurin Inhibitors in Patients with Primary Membranous Nephropathy.
    Am J Nephrol 2018 26;47(4):266-274. Epub 2018 Apr 26.
    Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Institute of Kidney Disease and Dialysis, Shanghai Key Laboratory of Kidney Disease and Blood Purification, Shanghai, China.
    Background: Currently, there is an urgent need to find ways of identifying primary membranous nephropathy (PMN) patients who are likely to benefit from calcineurin inhibitors (CNI) or who are resistant to them. In this study, we employed nano-HPLC-MS/MS analysis to identify serum biomarkers that predict the clinical response to CNI therapy in PMN patients.

    Methods: The endpoint was complete remission (CR) after CNI treatment. Read More

    Serum Obestatin: A Biomarker of Cardiovascular and All-Cause Mortality in Hemodialysis Patients.
    Am J Nephrol 2018 25;47(4):254-265. Epub 2018 Apr 25.
    Division of Nephrology, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel.
    Background: Recent experimental studies have suggested that obestatin, a proposed anorexigenic gut hormone and a physiological opponent of acyl-ghrelin, has protective cardiovascular effects. We tested the hypothesis that obestatin is independent of inflammatory mediators and/or acyl-ghrelin in predicting outcomes of the maintenance hemodialysis (MHD) population.

    Methods: It was a 6-year cohort study on 261 MHD patients. Read More

    Fibroblast Growth Factor 23: A Biomarker of Kidney Function Decline.
    Am J Nephrol 2018 5;47(4):242-250. Epub 2018 Apr 5.
    University of Alabama School of Medicine, Birmingham, Alabama, USA.
    Background: Fibroblast growth factor 23 (FGF-23) is a hormone that regulates phosphorus levels and vitamin D metabolism. Previous studies have shown FGF-23 to be a risk factor for incident end-stage renal disease; however, there are less data on the association of FGF-23 with earlier kidney-related outcomes.

    Methods: Serum FGF-23 was assayed using an intact ELISA assay in 2,496 participants of the Healthy Aging and Body Composition Study, a cohort of well-functioning older adults. Read More

    Changes in Biomarker Profile and Left Ventricular Hypertrophy Regression: Results from the Frequent Hemodialysis Network Trials.
    Am J Nephrol 2018 5;47(3):208-217. Epub 2018 Apr 5.
    Yale New Haven Health System, New Haven, Connecticut, USA.
    Background: Regression of left ventricular hypertrophy (LVH) is feasible with more frequent hemodialysis (HD). We aimed to ascertain pathways associated with regression of left ventricular mass (LVM) in patients enrolled in the Frequent HD Network (FHN) trials.

    Methods: This was a post hoc observational cohort study. Read More

    Levels of Endocan, Angiopoietin-2, and Hypoxia-Inducible Factor-1a in Patients with Autosomal Dominant Polycystic Kidney Disease and Different Levels of Renal Function.
    Am J Nephrol 2018 29;47(4):231-238. Epub 2018 Mar 29.
    Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Background: Endothelial dysfunction leading to unbalanced vasoconstriction and ischemia of renal parenchyma is increasingly proposed as an alternative pathway of renal damage in autosomal dominant polycystic kidney disease (ADPKD). However, human studies investigating the evolution of such phenomena are limited. This study investigated the levels of emerging biomarkers of endothelial function, angiogenesis and hypoxia, in ADPKD patients with different renal function. Read More

    Pregnancy Outcomes in French Hemodialysis Patients.
    Am J Nephrol 2018 27;47(4):219-227. Epub 2018 Mar 27.
    Service de Néphrologie, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
    Background: Pregnancy in hemodialysis (HD) women is a rare event and often associated with maternal and fetal complications. Scarcity of available data from large cohorts impedes fair medical counseling.

    Methods: This is a descriptive, retrospective, multi-centric study. Read More

    Telenephrology: Providing Healthcare to Remotely Located Patients with Chronic Kidney Disease.
    Am J Nephrol 2018 20;47(3):200-207. Epub 2018 Mar 20.
    Division of Nephrology, Northport VAMC, Northport, New York, USA.
    Background: Chronic kidney disease (CKD) patients who live far (>30 miles) from their nephrologist experience lower rates of clinic visit adherence, limited access to treatment, and higher rates of hospitalization and mortality than patients who live in close proximity to their nephrologist. Strategies to minimize disparities between urban and remotely located CKD patients are needed. The purpose of this study was to determine whether adherence to clinic visits and clinical outcomes in the remote management of CKD via telenephrology is comparable to in-person conventional care. Read More

    Renal Function Variability: An Independent Risk Factor for Graft Loss and Death following Kidney Transplantation.
    Am J Nephrol 2018 14;47(3):191-199. Epub 2018 Mar 14.
    Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
    Background: Several studies have been performed to evaluate surrogate markers of long-term allograft function in renal transplant recipients. These include serum creatinine, estimated glomerular filtration rate (eGFR), slope of eGFR, and more recently eGFR variability. The aim of this study was to measure eGFR slope while assessing the variability of this slope and if high variability occurring at any time post-transplant was predictive of poorer long-term outcomes in a large cohort of kidney transplant recipients. Read More

    The Cytochrome P450 3A5 Non-Expressor Kidney Allograft as a Risk Factor for Calcineurin Inhibitor Nephrotoxicity.
    Am J Nephrol 2018 14;47(3):182-190. Epub 2018 Mar 14.
    Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
    Background: Tacrolimus is mainly metabolized by cytochrome P450 3A5 (CYP3A5), which is expressed in the liver. However, CYP3A5 is also expressed in the kidney tissue and may contribute to local tacrolimus clearance in the kidney allograft. We aimed to evaluate the association between the allograft CYP3A5 genotype and transplant outcomes. Read More

    Gut Microbiota Dysbiosis in Children with Relapsing Idiopathic Nephrotic Syndrome.
    Am J Nephrol 2018 13;47(3):164-170. Epub 2018 Mar 13.
    Department of Pediatrics, Kansai Medical University, Osaka, Japan.
    Background: While the etiology of idiopathic nephrotic syndrome (idiopathic nephrotic syndrome [INS]; characterized by repeated relapses and comorbid allergic conditions) remains unknown, recent evidence suggests that dysfunction in regulatory T cells (Tregs) plays an important role in the development of INS as well as allergic diseases. We hypothesized that dysbiosis involving decreased butyric acid-producing gut microbiota leads to defective induction and differentiation of peripherally induced Tregs, resulting in INS relapse.

    Methods: Study subjects were 12 children with INS, 8 classified as relapsing (R group; median age: 3. Read More

    Race/Ethnicity, Dietary Acid Load, and Risk of End-Stage Renal Disease among US Adults with Chronic Kidney Disease.
    Am J Nephrol 2018 9;47(3):174-181. Epub 2018 Mar 9.
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, California, USA.
    Background: Dietary acid load (DAL) contributes to the risk of CKD and CKD progression. We sought to determine the relation of DAL to racial/ethnic differences in the risk of end-stage renal disease (ESRD) among persons with CKD.

    Methods: Among 1,123 non-Hispanic black (NHB) and non-Hispanic white (NHW) National Health and Nutrition Examination Survey III participants with estimated glomerular filtration rate 15-59 mL/min/1. Read More

    Real-World Scenario Improvements in Serum Phosphorus Levels and Pill Burden in Peritoneal Dialysis Patients Treated with Sucroferric Oxyhydroxide.
    Am J Nephrol 2018 7;47(3):153-161. Epub 2018 Mar 7.
    Washington University School of Medicine, St. Louis, Missouri, USA.
    Background: A database analysis was conducted to assess the effectiveness of sucroferric oxyhydroxide (SO) on lowering serum phosphorus and phosphate binder (PB) pill burden among adult peritoneal dialysis (PD) patients prescribed SO as part of routine care.

    Methods: Adult PD patients (n = 258) prescribed SO through a renal pharmacy service were analyzed. Baseline was 3 months before SO prescription. Read More

    Effects of Hydroxychloroquine on Proteinuria in Immunoglobulin A Nephropathy.
    Am J Nephrol 2018 2;47(3):145-152. Epub 2018 Mar 2.
    Background: Hydroxychloroquine (HCQ) is a well-known immunomodulator that is useful as in the treatment for lupus because of its inhibitory effect on toll-like receptors and cytokines, which are speculated to play a role in the pathogenesis of Immunoglobulin A (IgA) nephropathy (IgAN). However, there was only one study that investigated the effect of HCQ on proteinuria in patients with IgAN.

    Methods: Ninety patients with IgAN who received HCQ in addition to optimized dosage of renin-angiotensin-aldosterone system inhibitors (RAASi) were recruited for this study, and 90 matched historical controls who received RAASi alone were selected from our registry by the propensity score matching method. Read More

    Awareness of the New Kidney Allocation System among United States Dialysis Providers with Low Waitlisting.
    Am J Nephrol 2018 22;47(2):115-119. Epub 2018 Feb 22.
    Department of Medicine, Division of Renal Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
    It is unknown whether dialysis facility staff are aware of the new kidney allocation system implemented in December 2014, which changed how deceased donor kidneys are allocated and waiting time is calculated. U.S. Read More

    Repeated Bioimpedance Measurements Predict Prognosis of Peritoneal Dialysis Patients.
    Am J Nephrol 2018 22;47(2):120-129. Epub 2018 Feb 22.
    Background: Fluid overload is a major risk factor for mortality in patients undergoing peritoneal dialysis (PD). However, few studies have investigated the effect of chronic exposure to sustained fluid overload on long-term outcomes.

    Method: A total of 284 prevalent PD patients were included in this prospective study. Read More

    Presence of Kidney Disease as an Outcome Predictor in Patients with Pulmonary Arterial Hypertension.
    Am J Nephrol 2018 22;47(2):134-143. Epub 2018 Feb 22.
    Nephrology Department, Edouard Herriot Academic Hospital, Hospices Civils de Lyon, Lyon, France.
    Background: Pulmonary arterial hypertension (PAH) may lead to right heart failure and subsequently alter glomerular filtration rates (GFR). Chronic kidney disease (CKD, GFR <60 mL/min/1.73 m2) may also adversely affect PAH prognosis. Read More

    What We Do and Do Not Know about Women and Kidney Diseases; Questions Unanswered and Answers Unquestioned: Reflection on World Kidney Day and International Women's Day.
    Am J Nephrol 2018 16;47(2):103-114. Epub 2018 Feb 16.
    Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
    Chronic kidney disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. Girls and women, who make up approximately 50% of the world's population, are important contributors to society and their families. Read More

    miR-499 Ameliorates Podocyte Injury by Targeting Calcineurin in Minimal Change Disease.
    Am J Nephrol 2018 15;47(2):94-102. Epub 2018 Feb 15.
    Background: Podocyte injury is a hallmark of minimal change disease (MCD). Calcineurin inhibitors have been widely used in the current treatment of MCD, and miR-499 may target calcineurin. We aimed to study the function of miR-499 in MCD and test whether miR-499 delivery can improve MCD. Read More

    Effect of the Opioid Crisis on the Donor Pool for Kidney Transplantation: An Analysis of National Kidney Deceased Donor Trends from 2010-2016.
    Am J Nephrol 2018 13;47(2):84-93. Epub 2018 Feb 13.
    Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA.
    Background: The opioid crisis has led to a dramatic increase in the number of drug overdose deaths in the United States. Little is known about the effect of the opioid crisis on the kidney transplant donor pool, particularly on hepatitis C virus (HCV)-infected donors.

    Methods: This is a retrospective analysis of the data from the Organ Procurement and Transplantation Network from 2010 to 2016. Read More

    Positive Iron Balance in Chronic Kidney Disease: How Much is Too Much and How to Tell?
    Am J Nephrol 2018 13;47(2):72-83. Epub 2018 Feb 13.
    Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, California, USA.
    Background: Regulation of body iron occurs at cellular, tissue, and systemic levels. In healthy individuals, iron absorption and losses are minimal, creating a virtually closed system. In the setting of chronic kidney disease and hemodialysis (HD), increased iron losses, reduced iron absorption, and limited iron availability lead to iron deficiency. Read More

    Bardoxolone Methyl Improves Kidney Function in Patients with Chronic Kidney Disease Stage 4 and Type 2 Diabetes: Post-Hoc Analyses from Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes Study.
    Am J Nephrol 2018 18;47(1):40-47. Epub 2018 Jan 18.
    Reata Pharmaceuticals, Irving, Texas, USA.
    Background: Increases in measured inulin clearance, measured creatinine clearance, and estimated glomerular filtration rate (eGFR) have been observed with bardoxolone methyl in 7 studies enrolling approximately 2,600 patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). The largest of these studies was Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes (BEACON), a multinational, randomized, double-blind, placebo-controlled phase 3 trial which enrolled patients with T2D and CKD stage 4. The BEACON trial was terminated after preliminary analyses showed that patients randomized to bardoxolone methyl experienced significantly higher rates of heart failure events. Read More

    Prevalence of Chronic Kidney Disease, Thrombotic Cardiovascular Events, and Use of Oral P2Y12 Inhibitors among Veterans.
    Am J Nephrol 2018 1;47(2):67-71. Epub 2018 Feb 1.
    University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
    Background: Contemporary prevalence of chronic kidney disease (CKD) and thrombotic cardiovascular (CV) events remains unclear in Veterans enrolled in the Veterans Affairs Health Care System (VA) care. Although oral P2Y12 inhibitors (P2Y12i) are increasingly being prescribed to this patient population, the overall prescription trend for P2Y12i remains unclear.

    Methods: Using national VA corporate warehouse data, we used International Classification of Diseases-9 codes to identify Veterans with CKD, dialysis-dependent CKD, and CV events. Read More

    Body Mass Index Change and Hospitalization Risk in Elderly Hemodialysis Patients: Results from Japanese Dialysis Outcomes and Practice Patterns Study.
    Am J Nephrol 2018 24;47(1):48-56. Epub 2018 Jan 24.
    Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan.
    Background: Short-term weight gains and losses are associated with a lower and higher mortality risk, respectively, in patients undergoing hemodialysis (HD). However, little is known about their association with the risk of subsequent hospitalization.

    Methods: In a prospective cohort of 1,804 HD patients aged ≥65 years enrolled in the Japanese Dialysis Outcomes and Practice Patterns Study phases 3 (2005-2008) and 4 (2009-2011), we examined the associations between changes in body mass index (BMI) over a 4-month baseline period (<-3%, -3 to <-1%, -1 to <1% [reference], 1 to <3%, and ≥3%) and subsequent risk of all-cause, cardiovascular, and noncardiovascular hospitalization using Cox models with adjustment for potential confounders. Read More

    Dietary Sodium/Potassium Intake Does Not Affect Cognitive Function or Brain Imaging Indices.
    Am J Nephrol 2018 24;47(1):57-65. Epub 2018 Jan 24.
    Division of Renal Diseases and Hypertension, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA.
    Background: Dietary sodium may influence cognitive function through its effects on cerebrovascular function and cerebral blood flow.

    Methods: The aim of this study was to evaluate the association of dietary sodium intake with cognitive decline in community-dwelling older adults. We also evaluated the associations of dietary potassium and sodium:potassium intake with cognitive decline, and associations of these nutrients with micro- and macro-structural brain magnetic resonance imaging (MRI) indices. Read More

    Long-Term Survivor Characteristics in Hemodialysis Patients with Type 2 Diabetes.
    Am J Nephrol 2018 10;47(1):30-39. Epub 2018 Jan 10.
    Department of Internal Medicine I, Division of Nephrology, University of Würzburg, Würzburg, Germany.
    Background: Data concerning long-term mortality predictors among large, purely diabetic hemodialysis collectives are scarce.

    Methods: We used data from a multicenter, prospective, randomized trial among 1,255 hemodialysis patients with type 2 diabetes mellitus (T2DM) and its observational follow-up study. The association of 10 baseline candidate variables with mortality was assessed by Cox proportional hazards regression. Read More

    Comparison of Glycemic Markers in Chronic Hemodialysis Using Continuous Glucose Monitoring.
    Am J Nephrol 2018 22;47(1):21-29. Epub 2017 Dec 22.
    1st Propedeutic Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Background: Glycated hemoglobin A1c (HbA1c) among diabetic hemodialysis patients continues to be the standard of care, although its limitations are well recognized. This study evaluated glycated albumin (GA) and glycated serum protein (GSP) as alternatives to HbA1c in detecting glycemic control among diabetic hemodialysis patients using continuous-glucose-monitoring (CGM)-derived glucose as reference standard.

    Methods: A CGM system (iPRO) was applied for 7 days in 37 diabetic hemodialysis patients to determine glycemic control. Read More

    Tubular Cell Senescence in the Donated Kidney Predicts Allograft Function, but Not Donor Remnant Kidney Function, in Living Donor Kidney Transplantation.
    Am J Nephrol 2018 22;47(1):8-17. Epub 2017 Dec 22.
    Division of Nephrology and Dialysis, Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University, Kagawa, Japan.
    Background: It is uncertain whether kidneys from marginal donors are suitable for live kidney transplantation. In deceased donor kidneys, tubular cell senescence affects allograft function. However, the degree of cell senescence in a living donor kidney with marginal factors has not been reported. Read More

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