3,864 results match your criteria American journal of nephrology[Journal]


End-Stage Kidney Diseases in Immigrant Groups: A Nationwide Cohort Study in Sweden.

Am J Nephrol 2019 Feb 1;49(3):186-192. Epub 2019 Feb 1.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

Background: Our aim was to study the association between the country of birth and incident end-stage kidney disease (ESKD) in several immigrant groups in Sweden, using individuals born in Sweden or with Swedish-born parents as referents.

Methods: A cohort study of first- and second-generation immigrants residing in Sweden between January 1, 1998 and December 31, 2012 was performed. Outcomes were defined as having at least one registered diagnosis of ESKD in the National Patient Register. Read More

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https://www.karger.com/Article/FullText/497063
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http://dx.doi.org/10.1159/000497063DOI Listing
February 2019
4 Reads

A Placebo-Controlled, Randomized Trial of Enarodustat in Patients with Chronic Kidney Disease Followed by Long-Term Trial.

Am J Nephrol 2019 30;49(2):165-174. Epub 2019 Jan 30.

Fukuoka Renal Clinic, Fukuoka, Japan.

Background: Enarodustat (JTZ-951) is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that mimics adaptive responses to hypoxic conditions and may provide a new therapeutic approach for managing anemia in patients with chronic kidney disease (CKD). We evaluated the efficacy, safety, and maintenance dose of enarodustat in anemic patients with CKD not on dialysis.

Methods: Erythropoiesis-stimulating agent (ESA) naïve patients (correction group) and patients on a stable dose of ESA (conversion group) were randomized to receive 2, 4, or 6 mg of enarodustat or placebo once daily for 6 weeks in a double-blind manner (Period 1) followed by 24 weeks of open enarodustat treatment to maintain their hemoglobin (Hb) levels within a target range of 10. Read More

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https://www.karger.com/Article/FullText/496929
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http://dx.doi.org/10.1159/000496929DOI Listing
January 2019
2 Reads

Postoperative Acute Kidney Injury: Focus on Renal Recovery Definitions, Kidney Disease Progression and Survival.

Am J Nephrol 2019 Jan 30;49(3):175-185. Epub 2019 Jan 30.

Faculty of Medicine, University of Iceland, Reykjavik,

Background: The aim of this study was to examine different definitions of renal recovery following postoperative acute kidney injury (AKI) and how these definitions associate with survival and the development and progression of chronic kidney disease (CKD).

Methods: This was a retrospective study of all patients who underwent abdominal, cardiothoracic, vascular, or orthopedic surgery at a single university hospital between 1998 and 2015. Recovery of renal function following postoperative AKI was assessed comparing 4 different definitions: serum creatinine (SCr) (i) < 1. Read More

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http://dx.doi.org/10.1159/000496611DOI Listing
January 2019

Clinical Outcomes of Arteriovenous Access in Incident Hemodialysis Patients with Medicare Coverage, 2012-2014.

Am J Nephrol 2019 24;49(2):156-164. Epub 2019 Jan 24.

Humacyte Incorporated, Morrisville, North Carolina,

Background: Chronic hemodialysis requires a mode of vascular access through an arteriovenous fistula (AVF), a prosthetic arteriovenous graft (AVG), or a central venous catheter (CVC). AVF is recommended over AVG or CVC due to increased patency and decreased intervention rates for those that mature. AVG are preferred over CVC due to decreased infection and mortality risk. Read More

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http://dx.doi.org/10.1159/000495355DOI Listing
January 2019
2 Reads

Albuminuria Regression in Diabetes: A Therapeutic Target for Nephro- and Cardio-Protection, in Clinics and Research.

Am J Nephrol 2019 24;49(2):143-145. Epub 2019 Jan 24.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan,

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http://dx.doi.org/10.1159/000496275DOI Listing
January 2019

Albuminuria Regression and All-Cause Mortality among Insulin-Treated Patients with Type 2 Diabetes: Analysis of a Large UK Primary Care Cohort.

Am J Nephrol 2019 24;49(2):146-155. Epub 2019 Jan 24.

Division of Graduate Entry Medicine, School of Medicine, University of Nottingham, Nottingham, United

Background: Overt albuminuria (urinary albumin-creatinine ratio [ACR] > 300 mg/g) is an established risk factor for progression of nephropathy and total mortality. However, whether a reduction in ACR translates into a reduction in mortality and/or cardiovascular (CV) events among insulin-treated patients with type 2 diabetes (T2D) in routine practice is currently not known.

Methods: We obtained data on a large cohort of insulin users with T2D and nephropathy (baseline ACR ≥300 mg/g) from UK general practices between 2007 and 2014. Read More

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http://dx.doi.org/10.1159/000496276DOI Listing
January 2019
7 Reads

Vancomycin-Associated Acute Kidney Injury in a Large Veteran Population.

Am J Nephrol 2019 24;49(2):133-142. Epub 2019 Jan 24.

Nephrology Section, Memphis Veterans Affairs Medical Center, Memphis, Tennessee,

Background: To determine the association of vancomycin with acute kidney injury (AKI) in relation to its serum concentration value and to examine the risk of AKI in patients treated with vancomycin when compared with a matched cohort of patients receiving non-glycopeptide antibiotics (linezolid/daptomycin).

Methods: From a cohort of > 3 million US veterans with baseline estimated glomerular filtration rate ≥60 mL/min/1.73 m2, we identified 33,527 patients who received either intravenous vancomycin (n = 22,057) or non-glycopeptide antibiotics (linezolid/daptomycin, n = 11,470). Read More

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http://dx.doi.org/10.1159/000496484DOI Listing
January 2019
1 Read
2.669 Impact Factor

Fibroblast Growth Factor 23 Genotype and Cardiovascular Disease in Patients Undergoing Hemodialysis.

Am J Nephrol 2019 22;49(2):125-132. Epub 2019 Jan 22.

Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana,

Background: Elevated serum concentrations of fibroblast growth factor 23 (FGF23) are associated with cardiovascular mortality in patients with chronic kidney disease and those undergoing dialysis.

Objectives: We tested the hypotheses that polymorphisms in FGF23, its co-receptor alpha-klotho (KL), and/or FGF23 receptors (FGFR) are associated with cardiovascular events and/or mortality.

Methods: We used 1,494 DNA samples collected at baseline from the Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events Trial, in which patients were randomized to the calcimimetic cinacalcet or placebo for the treatment of secondary hyperparathyroidism. Read More

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http://dx.doi.org/10.1159/000496060DOI Listing
January 2019
3 Reads

Cortical Perfusion and Tubular Function as Evaluated by Magnetic Resonance Imaging Correlates with Annual Loss in Renal Function in Moderate Chronic Kidney Disease.

Am J Nephrol 2019 22;49(2):114-124. Epub 2019 Jan 22.

Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA.

Background: Chronic hypoxia is a well-recognized factor in the pathogenesis of chronic kidney disease (CKD). Loss of microcirculation is thought to lead to enhanced renal hypoxia, which in turn results in the development of fibrosis, a hallmark of progressive CKD. To evaluate the role of functional magnetic resonance imaging (MRI), we performed perfusion, oxygenation, and diffusion MRI measurements in individuals with diabetes and stage 3 CKD. Read More

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http://dx.doi.org/10.1159/000496161DOI Listing
January 2019
1 Read
2.669 Impact Factor

Prediction of Chronic Kidney Disease Progression by Magnetic Resonance Imaging: Where Are We?

Am J Nephrol 2019 10;49(2):111-113. Epub 2019 Jan 10.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota,

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http://dx.doi.org/10.1159/000496160DOI Listing
January 2019
1 Read

Comorbidity, Frailty, and Waitlist Mortality among Kidney Transplant Candidates of All Ages.

Am J Nephrol 2019 9;49(2):103-110. Epub 2019 Jan 9.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland,

Background: Kidney transplantation (KT) candidates often present with multiple comorbidities. These patients also have a substantial burden of frailty, which is also associated with increased mortality. However, it is unknown if frailty is merely a surrogate for comorbidity, itself an independent domain of risk, or if frailty and comorbidity have differential effects. Read More

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http://dx.doi.org/10.1159/000496061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374203PMC
January 2019
3 Reads

Cardiovascular Outcomes in African Americans with Sickle Cell Trait and Chronic Kidney Disease.

Am J Nephrol 2019 9;49(2):93-102. Epub 2019 Jan 9.

Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background: Sickle cell trait (SCT) is common among African Americans and has been historically considered to be benign. Recently, SCT has been associated with an increased risk for chronic kidney disease (CKD) and cardiovascular disease in the general population. Our understanding of SCT has been extrapolated largely from data of patients with sickle cell disease (SCD). Read More

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http://dx.doi.org/10.1159/000496058DOI Listing
January 2019
2 Reads

C4d in Native Glomerular Diseases.

Authors:
Preeti Chandra

Am J Nephrol 2019 4;49(1):81-92. Epub 2019 Jan 4.

Complement activation occurs in many glomerular diseases, the exact pathway(s) of activation has been studied in detail in some diseases but not in all. C4d is generated by the activation of classical and lectin pathways, and its presence can point to the activation of either of these pathways. This review aims to summarize the available data with regard to the deposition of glomerular C4d in native kidney biopsies in different glomerular pathologies that may be useful for future research into the role of complement activation in glomerular diseases. Read More

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http://dx.doi.org/10.1159/000496059DOI Listing
January 2019
2 Reads

Effect of Bicarbonate-Buffered Dialysate on Ventricular Arrhythmias in Hemodialysis Patients.

Am J Nephrol 2019 2;49(1):74-80. Epub 2019 Jan 2.

Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, New York,

Background: The etiology of sudden cardiac death in patients with end-stage renal disease (ESRD) on hemodialysis (HD) is largely unknown, though there is evidence to suggest that metabolic alkalosis induced by HD with a high-bicarbonate dialysate/prescription may play a role.

Methods: We investigated the effects of metabolic alkalosis induced by HD with an acetate-containing bicarbonate-buffered dialysate on frequency of ventricular arrhythmia in 47 patients with ESRD on chronic HD using 48-h Holter monitoring in 3 phases: intra-HD, post-HD day 1, and post-HD day 2. Serum levels of bicarbonate, calcium, and potassium along with hemodynamics were measured pre-HD, post-HD, 20-h post-HD, and 44-h post-HD. Read More

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https://www.karger.com/Article/FullText/495846
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http://dx.doi.org/10.1159/000495846DOI Listing
January 2019
8 Reads

Short-Term Steroid Regimen for Adult Steroid-Sensitive Minimal Change Disease.

Am J Nephrol 2019 17;49(1):54-63. Epub 2018 Dec 17.

Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya,

Background: In pediatric patients with steroid-sensitive nephrotic syndrome, recent trials have revealed that a 2-month, short-term steroid regimen is not inferior to an extended steroid course. However, the optimal duration of initial steroid therapy for adult steroid-sensitive minimal change disease (MCD) remains unclear.

Objectives: The aim of present study was to evaluate the effectiveness of a 2-month, short-term steroid regimen in the treatment of adult steroid-sensitive MCD patients. Read More

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http://dx.doi.org/10.1159/000495352DOI Listing
December 2018
11 Reads

Sleep Duration and Proteinuria Progression: A Population-Based Cohort Study.

Am J Nephrol 2019 17;49(1):41-51. Epub 2018 Dec 17.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei,

Background: Extensive studies have demonstrated that sleep is an important modulator of cardiovascular and metabolic diseases. However, its impact on renal function remains uncertain.

Methods: A total of 26,249 adults aged ≥20 years were recruited through voluntary health examinations in Taiwan. Read More

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http://dx.doi.org/10.1159/000495847DOI Listing
December 2018
3 Reads

Association between Freestanding Dialysis Facility Size and Medicare Quality Incentive Program Performance Scores.

Am J Nephrol 2019 17;49(1):64-73. Epub 2018 Dec 17.

Department of Health Services Policy and Management, Columbia, South Carolina, USA.

Background: Medicare uses a quality incentive program (QIP) criteria to evaluate care in dialysis facilities and apply monetary penalties on underperforming facilities. Smaller dialysis facilities are likely to be rural and operate on lower profit margin; therefore, such facilities are likely to underperform and face Medicare penalties. The variation in QIP scores by facility size is not yet known. Read More

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https://www.karger.com/Article/FullText/495262
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http://dx.doi.org/10.1159/000495262DOI Listing
December 2018
3 Reads

Use of Hepatitis C Positive Organs: Patient Attitudes in Urban Chicago.

Am J Nephrol 2019 14;49(1):32-40. Epub 2018 Dec 14.

Department of Internal Medicine, Section of Gastroenterology, Hepatology, and Nutrition, The University of Chicago Medicine, Chicago, Illinois, USA.

Background: Hepatitis C virus (HCV)-infected organs are being transplanted in patients with and without HCV in the direct-acting antiviral era. Little is known about patient attitudes towards receiving an HCV-positive organ.

Objectives: The aim of this study is to determine transplant candidates' attitudes towards receiving HCV-positive organs. Read More

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http://dx.doi.org/10.1159/000495263DOI Listing
December 2018
1 Read

Trends in Opioid Prescribing Among Hemodialysis Patients, 2007-2014.

Am J Nephrol 2019 13;49(1):20-31. Epub 2018 Dec 13.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland,

Background: Hemodialysis (HD) patients frequently experience pain. Previous studies of HD patients suggest increased opioid prescribing through 2010. It remains unclear if this trend continued after 2010 or declined with national trends. Read More

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http://dx.doi.org/10.1159/000495353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341485PMC
December 2018
2 Reads

Increased Mortality Associated with Higher Pre-Dialysis Serum Sodium Variability: Results of the International MONitoring Dialysis Outcome Initiative.

Am J Nephrol 2019 13;49(1):1-10. Epub 2018 Dec 13.

Renal Research Institute, New York, New York, USA.

Background: Low serum sodium (SNa) is associated with an increased mortality in chronic hemodialysis (HD) patients. Dialysis patients are thought to have an individual pre-dialysis SNa set-point, yet there is evidence for variability of pre-dialysis SNa in individual patient. In this study, we explored the association of several SNa variability metrics with all-cause mortality in a large patient population from the international MONitoring Dialysis Outcomes (MONDO) Initiative. Read More

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https://www.karger.com/Article/FullText/495354
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http://dx.doi.org/10.1159/000495354DOI Listing
December 2018
6 Reads

Gender Disparities in Vascular Access Surgical Outcomes in Elderly Hemodialysis Patients.

Am J Nephrol 2019 13;49(1):11-19. Epub 2018 Dec 13.

Division of Nephrology, Department of Medicine, University of Alabama at, Birmingham, Alabama, USA.

Background: Despite national vascular access guidelines promoting the use of arteriovenous fistulas (AVF) over arteriovenous grafts (AVGs) for dialysis, AVF use is substantially lower in females. We assessed clinically relevant AVF and AVG surgical outcomes in elderly male and female patients initiating hemodialysis with a central venous catheter (CVC).

Methods: Using the United States Renal Data System standard analytic files linked with Medicare claims, we assessed incident hemodialysis patients in the United States, 9,458 elderly patients (≥67 years; 4,927 males and 4,531 females) initiating hemodialysis from July 2010 to June 2011 with a catheter and had an AVF or AVG placed within 6 months. Read More

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http://dx.doi.org/10.1159/000495261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336522PMC
December 2018
1 Read

Antibodies against M-Type Phospholipase A2 Receptor May Predict Treatment Response and Outcome in Membranous Nephropathy.

Am J Nephrol 2018 23;48(6):438-446. Epub 2018 Nov 23.

Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.

Background: Anti-phospholipase A2 receptor (PLA2R) antibodies are specific to the diagnosis of primary membranous nephropathy (pMN). The prevalence of positive antibodies varies among different cohorts. Still there is discrepancy in regard to the association between antibody levels and clinical courses, and the prognostic value of antibodies to treatment responses and kidney outcomes. Read More

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https://www.karger.com/Article/FullText/494662
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http://dx.doi.org/10.1159/000494662DOI Listing
November 2018
12 Reads
2.669 Impact Factor

Identifying High-Risk Individuals for Chronic Kidney Disease: Results of the CHERISH Community Demonstration Project.

Am J Nephrol 2018 23;48(6):447-455. Epub 2018 Nov 23.

Centers for Disease Control and Prevention, Center for Global Health, Atlanta, Georgia, USA.

Background: Most people with chronic kidney disease (CKD) are not aware of their condition.

Objectives: To assess screening criteria in identifying a population with or at high risk for CKD and to determine their level of control of CKD risk factors.

Method: CKD Health Evaluation Risk Information Sharing (CHERISH), a demonstration project of the Centers for Disease Control and Prevention, hosted screenings at 2 community locations in each of 4 states. Read More

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http://dx.doi.org/10.1159/000495082DOI Listing
November 2018
3 Reads

Itraconazole Attenuates Peritoneal Fibrosis Through Its Effect on the Sonic Hedgehog Signaling Pathway in Mice.

Am J Nephrol 2018 23;48(6):456-464. Epub 2018 Nov 23.

Division of Nephrology, Department of Internal Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Republic of

Background: Peritoneal fibrosis is a devastating complication of peritoneal dialysis. However, its precise mechanism is unclear, and specific treatments have not yet been established. Recent evidence suggests that the sonic hedgehog (SHH) signaling pathway is involved in tissue fibrogenesis. Read More

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http://dx.doi.org/10.1159/000493550DOI Listing
November 2018
2 Reads

Trends in the Causes of Death among Kidney Transplant Recipients in the United States (1996-2014).

Am J Nephrol 2018 23;48(6):472-481. Epub 2018 Nov 23.

Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

Background: Death with graft function remains an important cause of graft loss among kidney transplant recipients (KTRs). Little is known about the trend of specific causes of death in KTRs in recent years.

Methods: We analyzed United States Renal Data System data (1996-2014) to determine 1- and 10-year all-cause and cause-specific mortality in adult KTRs who died with a functioning allograft. Read More

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https://www.karger.com/Article/FullText/495081
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http://dx.doi.org/10.1159/000495081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347016PMC
November 2018
12 Reads

Predictors of Renal Outcomes in Sclerotic Class Anti-Neutrophil Cytoplasmic Antibody Glomerulonephritis.

Am J Nephrol 2018 23;48(6):465-471. Epub 2018 Nov 23.

Johns Hopkins University, Baltimore, Maryland, USA.

Background: The prognostic value of the anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (GN) classification has been demonstrated in several cohorts with sclerotic class having the worst renal outcome. Relevant published data on factors predicting outcomes in sclerotic ANCA GN is limited.

Methods: Sclerotic ANCA GN patients were recruited from 5 centers worldwide for this retrospective cohort study. Read More

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http://dx.doi.org/10.1159/000494840DOI Listing
November 2018
11 Reads

Impact of Assisted Peritoneal Dialysis Modality on Outcomes: A Cohort Study of the French Language Peritoneal Dialysis Registry.

Am J Nephrol 2018 21;48(6):425-433. Epub 2018 Nov 21.

Néphrologie, CHU Caen, Avenue de la Côte de Nacre, Caen,

Background: Patients on peritoneal dialysis (PD) can be assisted by a nurse or a family member and treated either by automated PD (APD) or continuous ambulatory PD (CAPD). The aim of this study was to evaluate the effect of PD modality and type of assistance on the risk of transfer to haemodialysis (HD) and on the peritonitis risk in assisted PD patients.

Method: This was a retrospective study based on data from the French Language PD Registry. Read More

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http://dx.doi.org/10.1159/000494664DOI Listing
November 2018
7 Reads

Genome-Scale Single Nucleotide Resolution Analysis of DNA Methylation in Human Autosomal Dominant Polycystic Kidney Disease.

Am J Nephrol 2018 21;48(6):415-424. Epub 2018 Nov 21.

Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New

Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of fluid-filled cysts in the kidney and end stage renal disease by the fourth or fifth decade of life. Mutations in the PKD1 gene account for 85% of all cases of ADPKD. No curative therapy exists for patients affected by this disease and an underexplored avenue for the treatment of ADPKD is the targeting of epigenetic changes that occur during cystogenesis. Read More

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http://dx.doi.org/10.1159/000494739DOI Listing
November 2018
13 Reads

Association of Abdominal Adiposity with Cardiovascular Mortality in Incident Hemodialysis.

Am J Nephrol 2018 14;48(6):406-414. Epub 2018 Nov 14.

Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario,

Background: The risk of cardiovascular mortality is high among adults with end-stage renal disease (ESRD) undergoing hemodialysis. Waist-to-hip ratio (WHR), a metric of abdominal adiposity, is a predictor of cardiovascular disease (CVD) and mortality in the general population; however, no studies have examined the association with CVD mortality, particularly sudden cardiac death (SCD), in incident hemodialysis.

Methods: Among 379 participants incident (< 6 months) to hemodialysis enrolled in the Predictors of Arrhythmic and Cardiovascular Risk in ESRD study, we evaluated associations between WHR and risk of CVD mortality, SCD, and non-CVD mortality in Cox proportional hazards regression models. Read More

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https://www.karger.com/Article/FullText/494281
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http://dx.doi.org/10.1159/000494281DOI Listing
November 2018
18 Reads

Rhabdomyolysis among Critically Ill Combat Casualties: Long-Term Outcomes.

Am J Nephrol 2018 14;48(6):399-405. Epub 2018 Nov 14.

David Grant USAF Medical Center, Fairfield, California,

Background: Although rhabdomyolysis has been associated with acute kidney injury and mortality in the short term, the long-term consequences of an episode of rhabdomyolysis remain unknown. We sought to identify the long-term outcomes of rhabdomyolysis, including mortality, renal function, and incidence of hypertension (HTN), among service members initially admitted to the intensive care unit after sustaining a combat injury in Iraq or Afghanistan between February 1, 2002 and February 1, 2011.

Methods: Information on age, sex, injury severity score, mechanism of injury, serum creatinine, burn injury, presenting mean arterial pressure, and creatine kinase were retrospectively collected and analyzed for 2,208 patients. Read More

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https://www.karger.com/Article/FullText/494337
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http://dx.doi.org/10.1159/000494337DOI Listing
November 2018
9 Reads

No Survival Benefit in Octogenarians and Nonagenarians with Extended Hemodialysis Treatment Time.

Am J Nephrol 2018 13;48(5):389-398. Epub 2018 Nov 13.

Harold Simmons Center for Kidney Disease Research and Epidemiology, University of California Irvine, School of Medicine, Orange, Florida,

Background: The population of elderly end-stage renal disease patients initiating dialysis is rapidly growing. Although longer treatment is supposed to benefit for hemodialysis (HD) patients through more solute clearance and slower fluid removal, it is not yet clear how treatment session length affects mortality risk in octogenarians and nonagenarians.

Methods: In a cohort of 112,026 incident HD patients between 2007 and 2011, we examined the association of treatment session length with all-cause mortality, adjusting for demographics and comorbid conditions. Read More

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https://www.karger.com/Article/FullText/494336
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http://dx.doi.org/10.1159/000494336DOI Listing
November 2018
13 Reads
2.669 Impact Factor

Mammalian Target of Rapamycin Complex 1 Activation Disrupts the Low-Density Lipoprotein Receptor Pathway: A Novel Mechanism for Extracellular Matrix Accumulation in Human Peritoneal Mesothelial Cells.

Am J Nephrol 2018 13;48(5):357-368. Epub 2018 Nov 13.

Peritoneal fibrosis (PF) is characterized by progressive extracellular matrix (ECM) accumulation. Increasing evidence has suggested that ECM synthesis was increased in human peritoneal mesothelial cells (HPMCs) under high-glucose conditions, but the effects of high-glucose peritoneal dialysis solution (PDS) on ECM synthesis have not been fully elucidated. The aim of this study was to explore the potential mechanisms of high-glucose PDS-induced production of ECM in HPMCs. Read More

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https://www.karger.com/Article/FullText/494144
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http://dx.doi.org/10.1159/000494144DOI Listing
November 2018
12 Reads

Intradialytic Hypotension: Is Midodrine the Answer?

Am J Nephrol 2018 13;48(5):378-380. Epub 2018 Nov 13.

Department of Medicine, Comprehensive Hypertension Center, University of Chicago Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1159/000494805DOI Listing
November 2018
2 Reads

The Impact of Midodrine on Outcomes in Patients with Intradialytic Hypotension.

Am J Nephrol 2018 13;48(5):381-388. Epub 2018 Nov 13.

DaVita Institute for Patient Safety, Inc, Denver, Colorado, USA.

Background: Intradialytic hypotension (IDH) is a frequent complication of hemodialysis, and is associated with significant morbidity and mortality. Off-label use of the alpha-1 andrenergic receptor agonist midodrine to reduce the frequency and severity of IDH is common. However, limited data exist to support this practice. Read More

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http://dx.doi.org/10.1159/000494806DOI Listing
November 2018
1 Read

Coronary Artery Calcification in Hemodialysis and Peritoneal Dialysis.

Am J Nephrol 2018 13;48(5):369-377. Epub 2018 Nov 13.

Dianet Dialysis Centers, Utrecht, The Netherlands.

Background: Vascular calcification is seen in most patients on dialysis and is strongly associated with cardiovascular mortality. Vascular calcification is promoted by phosphate, which generally reaches higher levels in hemodialysis than in peritoneal dialysis. However, whether vascular calcification develops less in peritoneal dialysis than in hemodialysis is currently unknown. Read More

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http://dx.doi.org/10.1159/000494665DOI Listing
November 2018
2 Reads

Effects of L-Carnitine on Mineral Metabolism in the Multicentre, Randomized, Double Blind, Placebo-Controlled CARNIDIAL Trial.

Am J Nephrol 2018 8;48(5):349-356. Epub 2018 Nov 8.

Department of Biology, AP-HP, Necker Hospital, Paris Descartes University, Paris, France.

Background: The use of L-carnitine has been proposed in haemodialysis (HD) when deficiency is present to improve anaemia resistant to erythropoietin stimulating agent, intradialytic hypotension or cardiac failure. We tested the effects of L-carnitine supplementation on parameters of chronic kidney disease-mineral bone disorder.

Methods: CARNIDIAL was a randomized, double-blinded trial having included 92 incident HD subjects for a 1-year period to receive L-carnitine versus placebo. Read More

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https://www.karger.com/Article/FullText/494338
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http://dx.doi.org/10.1159/000494338DOI Listing
November 2018
15 Reads

Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate.

Am J Nephrol 2018 2;48(5):339-348. Epub 2018 Nov 2.

University of Colorado, Renal Diseases and Hypertension, Aurora, Colorado, USA.

Background: Heat stress and rhabdomyolysis are major risk factors for the occurrence of repeated acute kidney injury in workers exposed to heat and strenuous work. These episodes, in turn, may progress to chronic kidney disease.

Objective: The purpose of this study was to test the effect of allopurinol (AP) and sodium bicarbonate on the kidney injury induced by recurrent heat stress dehydration with concomitant repeated episodes of rhabdomyolysis. Read More

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http://dx.doi.org/10.1159/000494663DOI Listing
November 2018
4 Reads

Vascular Calcification Markers and Hemodialysis Vascular Access Complications.

Am J Nephrol 2018 31;48(5):330-338. Epub 2018 Oct 31.

Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin,

Background: Arteriovenous (AV) access dysfunction is a common complication in hemodialysis patients. Markers of vascular calcification are associated with cardiovascular outcomes and mortality in this population, but their association with vascular access outcomes is unknown. In this study, we aimed to evaluate the association between selected vascular calcification makers and vascular access complications in a cohort of hemodialysis patients. Read More

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https://www.karger.com/Article/FullText/493549
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http://dx.doi.org/10.1159/000493549DOI Listing
October 2018
16 Reads

Changing Trends in the Performance of Percutaneous Renal Biopsy from Nephrologist to Interventional Radiologist: A Single-Center Experience.

Am J Nephrol 2018 24;48(5):326-329. Epub 2018 Oct 24.

Background: Percutaneous renal biopsy of native kidneys (PRB) has been an integral part of the practice of nephrology. However, over the past 30 years, PRB has transitioned from a procedure performed only by nephrologists to interventional radiologists (IRs). We surveyed practicing nephrologists completing training in our program to determine the clinical practice patterns of PRB. Read More

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http://dx.doi.org/10.1159/000493925DOI Listing
October 2018
10 Reads

A Comparative Study of Short-Term Blood Pressure Variability in Hemodialysis Patients with and without Intradialytic Hypertension.

Am J Nephrol 2018 22;48(4):295-305. Epub 2018 Oct 22.

Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: Short-term blood pressure (BP) variability (BPV) is associated with increased cardiovascular risk in hemodialysis. Patients with intradialytic hypertension have high risk of adverse outcomes. Whether BPV is increased in these patients is not clear. Read More

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http://dx.doi.org/10.1159/000493989DOI Listing
October 2018
2 Reads

Autosomal Dominant Polycystic Kidney Disease: Clinical Assessment of Rapid Progression.

Am J Nephrol 2018 22;48(4):308-317. Epub 2018 Oct 22.

Department of Nephrology, Inherited Renal Disorders, Fundació Puigvert, REDINREN, IIB Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: Autosomal dominant polycystic kidney disease (ADPKD) causes the development of renal cysts and leads to a decline in renal function. Limited guidance exists in clinical practice on the use of tolvaptan. A decision algorithm from the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Working Groups of Inherited Kidney Disorders and European Renal Best Practice (WGIKD/ERBP) has been proposed to identify candidates for tolvaptan treatment; however, this algorithm has not been assessed in clinical practice. Read More

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http://dx.doi.org/10.1159/000493325DOI Listing
October 2018
3 Reads

Meet the Twins: Intradialytic and Interdialytic Hypertension.

Am J Nephrol 2018 22;48(4):292-294. Epub 2018 Oct 22.

Department of Medicine, Indiana University School of Medicine and Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1159/000493990DOI Listing
October 2018
1 Read

Polycystic Kidney Disease Progression: Learning from Europe.

Am J Nephrol 2018 22;48(4):306-307. Epub 2018 Oct 22.

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http://dx.doi.org/10.1159/000493326DOI Listing
October 2018
3 Reads

Gastrointestinal Disorders in Peritoneal Dialysis Patients.

Am J Nephrol 2018 19;48(5):319-325. Epub 2018 Oct 19.

Background: Gastrointestinal (GI) disorders in peritoneal dialysis (PD) patients are relatively understudied in the literature, even though they have a serious impact in the morbidity parameters and the quality of life for this group of patients. Various diagnostic tools have been used, including instrumental methods and questionnaires, invariably validated in comparative studies.

Summary: The prevalence of GI disorders is very high in PD patients. Read More

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https://www.karger.com/Article/FullText/494145
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http://dx.doi.org/10.1159/000494145DOI Listing
October 2018
15 Reads

Age-Related Macular Degeneration in Chronic Kidney Disease: A Meta-Analysis of Observational Studies.

Am J Nephrol 2018 18;48(4):278-291. Epub 2018 Oct 18.

Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.

Background: Age-related macular degeneration (AMD) is an important cause of blindness in aged people. Chronic kidney disease (CKD) was reported to be associated with a higher risk of AMD. However, supporting evidence was inconsistent between studies. Read More

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http://dx.doi.org/10.1159/000493924DOI Listing
October 2018
1 Read

Gut Microbial Product Predicts Cardiovascular Risk in Chronic Kidney Disease Patients.

Am J Nephrol 2018 16;48(4):269-277. Epub 2018 Oct 16.

Department of Internal Medicine-Nephrology, University of Michigan, Ann Arbor, Michigan, USA.

Background: The gut microbiota is altered in patients with chronic kidney disease (CKD), and cardiovascular risk increases with progressive CKD. This study examined the potential link between short chain fatty acids (SCFAs), which are produced by the gut microbiota, and cardiovascular outcomes in patients with CKD.

Methods: SCFAs were measured using a targeted liquid chromatography-mass spectrometry platform in baseline plasma samples from 214 patients with CKD enrolled in the Clinical Phenotyping Resource and Biobank Core; 81 patients with coronary artery disease (CAD) and 133 without CAD were randomly assigned to training and validation subsets. Read More

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https://www.karger.com/Article/FullText/493862
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http://dx.doi.org/10.1159/000493862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280192PMC
October 2018
15 Reads

Randomized Trial Comparing Proactive, High-Dose versus Reactive, Low-Dose Intravenous Iron Supplementation in Hemodialysis (PIVOTAL): Study Design and Baseline Data.

Am J Nephrol 2018 10;48(4):260-268. Epub 2018 Oct 10.

Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom.

Background: Intravenous (IV) iron supplementation is a standard maintenance treatment for hemodialysis (HD) patients, but the optimum dosing regimen is unknown.

Methods: PIVOTAL (Proactive IV irOn Therapy in hemodiALysis patients) is a multicenter, open-label, blinded endpoint, randomized controlled (PROBE) trial. Incident HD adults with a serum ferritin < 400 µg/L and transferrin saturation (TSAT) levels < 30% receiving erythropoiesis-stimulating agents (ESA) were eligible. Read More

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https://www.karger.com/Article/FullText/493551
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http://dx.doi.org/10.1159/000493551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262676PMC
October 2018
26 Reads

Comparing Therapeutic Efficacy and Safety of Epoetin Beta and Epoetin Alfa in the Treatment of Anemia in End-Stage Renal Disease Hemodialysis Patients.

Am J Nephrol 2018 25;48(4):251-259. Epub 2018 Sep 25.

Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Background: Anemia is one of the most prevalent complications in patients with chronic kidney disease, which is believed to be caused by the insufficient synthesis of erythropoietin by the kidney. This phase III study aimed to compare the efficacy and safety of CinnaPoietin® (epoetin beta, CinnaGen) with Eprex® (epoetin alfa, Janssen Cilag) in the treatment of anemia in ESRD hemodialysis patients.

Methods: In this randomized, active-controlled, double-blind, parallel, and non-inferiority trial, patients were randomized to receive either CinnaPoietin® or Eprex® for a 26-week period. Read More

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https://www.karger.com/Article/FullText/493097
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http://dx.doi.org/10.1159/000493097DOI Listing
September 2018
9 Reads