368,527 results match your criteria American journal of medical genetics. Part B Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics[Journal]


Designing a Mobile Game That Develops Emotional Resiliency in Indian Country.

Ext Abstr Hum Factors Computing Syst 2019 May;2019

Northern Arizona University, Flagstaff, AZ, USA.

Communities in Indian Country experience severe behavioral health inequities [11, 12]. Based on recent research investigating scalable behavioral health interventions and therapeutic best practices for Native American (NA) communities, we propose ARORA, a social and emotional learning intervention delivered over a networked mobile game that uses geosocial gaming mechanisms enhanced with augmented reality technology. Focusing on the Navajo community, we take a community-based participatory research approach to include NA psychologists, community health workers, and educators as co-designers of the intervention activities and gaming mechanisms. Read More

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http://dx.doi.org/10.1145/3290607.3312790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244226PMC

Contribution of Immunoscore and Molecular Features to Survival Prediction in Stage III Colon Cancer.

JNCI Cancer Spectr 2020 Jun 5;4(3):pkaa023. Epub 2020 Apr 5.

Division of Oncology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Background: The American Joint Committee on Cancer staging and other prognostic tools fail to account for stage-independent variability in outcome. We developed a prognostic classifier adding Immunoscore to clinicopathological and molecular features in patients with stage III colon cancer.

Methods: Patient (n = 559) data from the FOLFOX arm of adjuvant trial NCCTG N0147 were used to construct Cox models for predicting disease-free survival (DFS). Read More

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http://dx.doi.org/10.1093/jncics/pkaa023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236783PMC

Associations of Novel Dietary and Lifestyle Inflammation Scores With Incident Colorectal Cancer in the NIH-AARP Diet and Health Study.

JNCI Cancer Spectr 2020 Jun 5;4(3):pkaa009. Epub 2020 Mar 5.

Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.

Background: Chronically higher inflammation, likely contributed to by dietary and lifestyle exposures, may increase risk for colorectal cancer (CRC). To address this, we investigated associations of novel dietary (DIS) and lifestyle (LIS) inflammation scores with incident CRC in the prospective National Institutes of Health-American Association of Retired Persons Diet and Health Study (N = 453 465).

Methods: The components of our previously developed and externally validated 19-component DIS and 4-component LIS were weighted based on their strengths of associations with a panel of circulating inflammation biomarker concentrations in a diverse subset (N = 639) of participants in the REasons for Geographic and Racial Differences in Stroke Study cohort. Read More

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http://dx.doi.org/10.1093/jncics/pkaa009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236782PMC

Risk Stratification of Thyroid Nodules with Bethesda III Category: The Experience of a Territorial Healthcare Hospital.

Cureus 2020 May 19;12(5):e8202. Epub 2020 May 19.

Department of Endocrine Surgery, Prince Sultan Military Medical City, Riyadh, SAU.

Background The Bethesda System for Reporting Thyroid Cytolopathology (TBSRTC) is the standardized category-based reporting system for thyroid nodule (TN) aspirations; however, atypia of undetermined significance/follicular lesion of undetermined significance (Bethesda category III, AUS/FLUS) is the most controversial category. The aim of this study was to identify the degree of malignancy risk and the related risk factors in the surgical pathology of the Bethesda Category III thyroid nodules.  Methods A total of 4074 patients (15-90 years, 81. Read More

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http://dx.doi.org/10.7759/cureus.8202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241230PMC

The Chicken or the Egg? An Interesting Case Presentation of Spontaneous Coronary Artery Dissection Versus Takotsubo Cardiomyopathy.

Cureus 2020 Apr 23;12(4):e7793. Epub 2020 Apr 23.

Cardiology, University of Illinois College of Medicine at Peoria, Peoria, USA.

This is an interesting cardiovascular imaging and coronary angiography case of a 67-year-old female patient who presented with chest pain, abnormal electrocardiogram (EKG), and heart failure who was subsequently found to have spontaneous coronary artery dissection (SCAD) and Takotsubo cardiomyopathy (TCM) on imaging studies. The case presentation highlights the importance of imaging studies and prompt diagnosis in these patients. This study may also highlight the need for early medical intervention in patients with suspected systolic dysfunction due to either of these pathophysiologic processes. Read More

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http://dx.doi.org/10.7759/cureus.7793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243609PMC

Hyperprogressive Disease in an Advanced Stage Colon Cancer Patient on Pembrolizumab: A Case Report.

Cureus 2020 Apr 21;12(4):e7764. Epub 2020 Apr 21.

Hematology and Oncology, Saint Michael's Medical Center, Newark, USA.

The emergence of immune checkpoint inhibitors (ICIs) in recent years has transformed the landscape of the management of solid tumors. The advancement of immunotherapy has resulted in a brand new set of adverse outcomes not previously seen in classical chemotherapy. One such adverse effect has been termed as hyperprogressive disease (HPD), a phenomenon characterized by rapid tumor progression, which often leads to devastating outcomes. Read More

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http://dx.doi.org/10.7759/cureus.7764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243062PMC

Lamin A/C Cardiomyopathy with E203K Pathogenic Mutation.

Cureus 2020 Apr 21;12(4):e7761. Epub 2020 Apr 21.

Pediatrics, Beaumont Hospital, Royal Oak, USA.

Lamin A/C (LMNA) cardiomyopathy is an adult-onset, autosomal dominant, rapidly progressive cardiomyopathy which belongs to a spectrum of familial idiopathic cardiomyopathies. It is the most common type of familial dilated cardiomyopathy that is associated with conduction defects. A 76-year-old African American female with second-degree atrioventricular (AV) block presented for evaluation of persistent fatigue. Read More

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http://dx.doi.org/10.7759/cureus.7761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243065PMC

Splenectomy for Solitary Splenic Metastasis in Recurrent Papillary Thyroid Cancer. A Case Report and Literature Review.

Case Rep Oncol Med 2020 4;2020:2084847. Epub 2020 May 4.

Department of Surgical Oncology, American British Cowdray Medical Center, Mexico City, Mexico.

Thyroid cancer is the most common endocrine malignancy, presenting with 23 500 new cases per year in the United States. About 7-23% of the patients will present recurrent metastases disease during follow-up. The classic variant of papillary carcinoma is less aggressive compared to its other variants like diffuse sclerosing, tall cell or columnar cell, and insular variants, and the sites to which this metastasizes is already well identified. Read More

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http://dx.doi.org/10.1155/2020/2084847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232720PMC

Assessing Factors That Influence Healthcare Provider Attitudes and Practices regarding Place-Based Exercise Prescriptions: Results of Principal Components Analysis of a Newly Developed Survey Instrument.

Adv Prev Med 2020 11;2020:5084053. Epub 2020 May 11.

College of Public Health, Kent State University, Moulton Hall, 800 Hilltop Drive, Kent, OH 44242, USA.

Introduction: The purpose of this paper is to describe development and preliminary assessment of an instrument designed to assess facilitators and barriers of provider-provided, place-based exercise prescriptions, including provider attributes, perceptions, knowledge, and resource needs. Although the American Medical Association-Supported "Exercise is Medicine" initiative encourages the practice of exercise prescription among member providers, only a small proportion engages in this practice. Additionally, little is known about the role of place-based exercise prescriptions, although access to physical activity resources differs based on residence, access to transportation, income, and other factors. Read More

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http://dx.doi.org/10.1155/2020/5084053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238351PMC

Effect of Ketamine/Propofol Admixture on Peri-Induction Hemodynamics: A Systematic Review and Meta-Analysis.

Anesthesiol Res Pract 2020 8;2020:9637412. Epub 2020 May 8.

Evidence-Based Practice Center, Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.

To evaluate the effectiveness of an admixture of ketamine and propofol on peri-induction hemodynamics during airway manipulation, we searched electronic databases of randomized controlled trials from January 1, 2000, to October 17, 2018. Trial screening, selection, and data extraction were done independently by two reviewers with outcomes pooled across included trials using the random-effects model. We included 10 randomized trials (722 patients, mean age of 53. Read More

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http://dx.doi.org/10.1155/2020/9637412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231081PMC

COVID-19 and newborn health: systematic review.

Rev Panam Salud Publica 2020 27;44:e54. Epub 2020 Apr 27.

Pan American Health Organization/World Health Organization Pan American Health Organization/World Health Organization Montevideo Uruguay Pan American Health Organization/World Health Organization, Montevideo, Uruguay.

Objective: To describe perinatal and neonatal outcomes in newborns exposed to SARS-CoV-2.

Methods: A systematic review was conducted by searching PubMed Central, LILACS, and Google Scholar using the keywords 'covid ' AND 'newborn' OR 'child' OR 'infant,' on 18 March 2020, and again on 17 April 2020. One researcher conducted the search and extracted data on demographics, maternal outcomes, diagnostic tests, imaging, and neonatal outcomes. Read More

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http://dx.doi.org/10.26633/RPSP.2020.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241573PMC

Skin Permeation and Antifungal Activity of Naftifine Microemulsions.

Turk J Pharm Sci 2020 Feb 19;17(1):43-48. Epub 2020 Feb 19.

İstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, İstanbul, Turkey.

Objectives: Microemulsions are fluid, isotropic, colloidal systems that have been widely studied as drug delivery systems. The percutaneous transport of active agents can be enhanced by their microemulsion formulation when compared to conventional formulations. The purpose of this study was to evaluate naftifine-loaded microemulsions with the objective of improving the skin permeation of the drug. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.87699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227865PMC
February 2020

Diagnosis and Management of Graves' Disease in Thailand: A Survey of Current Practice.

J Thyroid Res 2020 11;2020:8175712. Epub 2020 May 11.

Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Background: The data on clinical practice patterns in the evaluation and management of Graves' disease (GD) are limited in Asia. The aims of this survey were to report the current practices in the management of GD in Thailand and to examine any international differences in the management of GD.

Methods: Members of the Endocrine Society of Thailand who were board certified in endocrinology ( = 392) were invited to participate in an electronic survey on the management of GD using the same index case and questionnaire as in previous North American and European surveys. Read More

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http://dx.doi.org/10.1155/2020/8175712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238361PMC

A Proposal for the Performance, Classification, and Reporting of Lymph Node Fine-Needle Aspiration Cytopathology: The Sydney System.

Acta Cytol 2020 May 26:1-17. Epub 2020 May 26.

Department of Medicine and Surgery, Università degli Studi di Salerno, Fisciano, Salerno, Italy,

Background: The evaluation of lymph nodes (LN) by fine-needle aspiration cytology (FNAC) is routinely used in many institutions but it is not uniformly accepted mainly because of the lack of guidelines and a cytopathological diagnostic classification. A committee of cytopathologists has developed a system of performance, classification, and reporting for LN-FNAC.

Methods: The committee members prepared a document that has circulated among them five times; the final text has been approved by all the participants. Read More

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http://dx.doi.org/10.1159/000506497DOI Listing

Exercise and Academic Performance Among Children With Attention-Deficit Hyperactivity Disorder and Disruptive Behavior Disorders: A Randomized Controlled Trial.

Pediatr Exerc Sci 2020 May 25:1-10. Epub 2020 May 25.

University of Illinois at Chicago.

Purpose: To examine effects of a 10-week after-school physical activity (PA) program on academic performance of 6- to 12-year-old African American children with behavior problems.

Methods: Participants were randomized to PA (n = 19) or sedentary attention control (n = 16) programs. Academic records, curriculum-based measures, and classroom observations were obtained at baseline, postintervention, and/or follow-up. Read More

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http://dx.doi.org/10.1123/pes.2019-0224DOI Listing

Measles is Back - Considerations for laboratory diagnosis.

J Clin Virol 2020 May 13;128:104430. Epub 2020 May 13.

Department of Infection, University College of London, London, UK; National Microbiology Services, NHS Blood and Transplant, London, UK.

Measles is a highly contagious viral illness that continues to cause significant mortality among young children worldwide despite the availability of a safe and effective vaccine. During the first half of 2019, over 182 countries reported more than 300,000 measles cases; greater than double the number from the same period in 2018. Timely recognition and laboratory confirmation of infected individuals as well as appropriate infection prevention measures are crucial to avert further transmission. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104430DOI Listing

Phylogeny of the North-Central American clade of blood-sucking reduviid bugs of the tribe Triatomini (Hemiptera: Triatominae) based on the mitochondrial genome.

Infect Genet Evol 2020 May 23:104373. Epub 2020 May 23.

Colección Nacional de Insectos, Instituto de Biología, Universidad Nacional Autónoma de México, 3er. circuito exterior s/n, Cd. Universitaria, Copilco, Coyoacán, A. P. 70-233, C. P. 04510, D. F., Mexico. Electronic address:

Triatominae is a subfamily of blood-sucking reduviid hemipterans of public health importance primarily in tropical and sub-tropical regions of the Americas, whose members possess various morphological adaptations closely associated to hematophagy. Despite their medical importance, the systematics of the subfamily is far from resolved, particularly within the tribe Triatomini. Here we employed mitochondrial genome DNA sequences to reconstruct the phylogenetic relationships among 19 species of the North-Central American (NCA) clade of Triatomini and to estimate the times of origin and diversification of its main clades. Read More

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http://dx.doi.org/10.1016/j.meegid.2020.104373DOI Listing

Goals-of-Care Consultation Associated with Increased Hospice Enrollment Among Propensity-Matched Cohorts of Seriously Ill African American and White Patients.

J Pain Symptom Manage 2020 May 23. Epub 2020 May 23.

School of Nursing, University of Pennsylvania.

Context: African Americans are less likely to receive hospice care and more likely to receive aggressive end-of-life care than Whites. Little is known about how palliative care consultation to discuss goals-of-care (hereafter "PCC") is associated with hospice enrollment by race.

Objectives: To compare enrollment in hospice at discharge between propensity-matched cohorts of African Americans with and without PCC, and Whites with and without PCC. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2020.05.020DOI Listing

An Arabidopsis DISEASE RELATED NONSPECIFIC LIPID TRANSFER PROTEIN 1 is required for resistance against various phytopathogens and tolerance to salt stress.

Gene 2020 May 23:144802. Epub 2020 May 23.

Department of Biology, Syracuse University, Syracuse, NY 13210. Electronic address:

Synchronous and timely regulation of multiple genes result in an effective defense response that decide the fate of the host when challenged with pathogens or unexpected changes in environmental conditions. One such gene, which is downregulated in response to multiple bacterial pathogens, is a putative nonspecific lipid transfer protein (nsLTP) of unknown function that we have named DISEASE RELATED NONSPECIFIC LIPID TRANSFER PROTEIN 1 (DRN1). We show that upon pathogen challenge, DRN1 is strongly downregulated, while a putative DRN1 targeting novel microRNA (miRNA) named DRN1 Regulating miRNA (DmiR) is reciprocally upregulated. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144802DOI Listing

Protein profiling in unlocking the basis of varicocele-associated infertility.

Andrologia 2020 May 26:e13645. Epub 2020 May 26.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Varicocele is one of the major causes of male infertility and has a negative impact on spermatogenesis. The conventional semen analysis does not reveal the underlying subcellular mechanisms associated with defects in spermatozoa. Proteomics and bioinformatics analysis can be used to identify the molecular aetiologies associated with poor semen quality in varicocele patients. Read More

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http://dx.doi.org/10.1111/and.13645DOI Listing

Patients eligible for modulator drugs: Data from cystic fibrosis registry of Turkey.

Pediatr Pulmonol 2020 May 26. Epub 2020 May 26.

Division of Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Background: A better understanding of cystic fibrosis transmembrane conductance regulator biology has led to the development of modulator drugs such as ivacaftor, lumacaftor-ivacaftor, tezacaftor-ivacaftor, and elexacaftor-tezacaftor-ivacaftor. This cross-sectional study evaluated cystic fibrosis (CF) patients eligible for modulator drugs.

Methods: Data for age and genetic mutations from the Cystic Fibrosis Registry of Turkey collected in 2018 were used to find out the number of patients who are eligible for modulator therapy. Read More

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http://dx.doi.org/10.1002/ppul.24854DOI Listing

Evaluation of the Spot Vision Screener in School-Aged Children.

J Pediatr Ophthalmol Strabismus 2020 May;57(3):146-153

Purpose: To determine the accuracy of the Spot Vision Screener (Welch Allyn, Skaneateles Falls, NY) in children 6 years and older and recommend device thresholds to improve its accuracy for the detection of refractive error.

Methods: The Spot Vision Screener results were compared with three gold standard conditions of increasingly narrow refractive error criterion. The sensitivity, specificity, positive predictive value, and negative predictive value of the Spot Vision Screener in detecting each gold standard criterion were calculated. Read More

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http://dx.doi.org/10.3928/01913913-20200331-02DOI Listing

Methodology for the American Society of Hematology VTE guidelines: current best practice, innovations, and experiences.

Blood Adv 2020 May;4(10):2351-2365

Michael G. DeGroote Cochrane Canada Centre.

Background: Methods for the development of clinical guidelines have advanced dramatically over the past 2 decades to strive for trustworthiness, transparency, user-friendliness, and rigor. The American Society of Hematology (ASH) guidelines on venous thromboembolism (VTE) have followed these advances, together with application of methodological innovations.

Objective: In this article, we describe methods and methodological innovations as a model to inform future guideline enterprises by ASH and others to achieve guideline standards. Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001768DOI Listing

Functional outcome in home health: Do racial and ethnic minority patients with dementia fare worse?

PLoS One 2020 26;15(5):e0233650. Epub 2020 May 26.

Department of Public Health Sciences, University of Rochester, Rochester, NY, United States of America.

Objectives: Evaluate the independent and interactive effects of dementia and racial/ethnic minority status on functional outcomes during a home health (HH) admission among Medicare beneficiaries.

Methods: Secondary analysis of data from the Outcome and Assessment Information Set [OASIS] and billing records in a non-profit HH agency in New York. Participants were adults ≥ 65 years old who received HH in CY 2017 with OASIS records at HH admission and HH discharge. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233650PLOS

Scientific Societies Fostering Inclusive Scientific Environments through Travel Awards: Current Practices and Recommendations.

CBE Life Sci Educ 2020 Jun;19(2):es3

Biophysical Society, Rockville, MD 20852.

Diversity-focused committees continue to play essential roles in the efforts of professional scientific societies to foster inclusion and facilitate the professional development of underrepresented minority (URM) young scientists in their respective scientific disciplines. Until recently, the efforts of these committees have remained independent and disconnected from one another. Funding from the National Science Foundation has allowed several of these committees to come together and form the Alliance to Catalyze Change for Equity in STEM Success, herein referred to as ACCESS. Read More

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http://dx.doi.org/10.1187/cbe.19-11-0262DOI Listing

The American Board of Industrial Hygiene: 60 years of progress.

J Occup Environ Hyg 2020 May 26:1-9. Epub 2020 May 26.

R&R Environmental, Inc, Sandy, Utah.

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http://dx.doi.org/10.1080/15459624.2020.1745819DOI Listing

Quality Indicators of Central Compartment Neck Dissection in Thyroid Surgery.

Otolaryngol Head Neck Surg 2020 May 26:194599820925757. Epub 2020 May 26.

Department of Otolaryngology-Head and Neck Surgery, University of Ottawa, Ottawa, Ontario, Canada.

Objectives: Quality metrics are an increasingly important means of improving patient care. Variability in the number of lymph nodes removed during central compartment lymph node dissection (CCLND) at the time of thyroidectomy has not been studied.

Study Design: A retrospective cohort study was performed using American College of Surgeons National Quality Improvement Program (ACS-NSQIP) data. Read More

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http://dx.doi.org/10.1177/0194599820925757DOI Listing

The Changing Health Insurance Coverage Landscape in the United States.

Am Soc Clin Oncol Educ Book 2020 May;40:e264-e274

University of Michigan Center for Value-Based Insurance Design, Ann Arbor, MI.

Changes in the health insurance coverage landscape in the United States during the past decade have important implications for receipt and affordability of cancer care. In this paper, we summarize evidence for the association between health insurance coverage and cancer prevention and treatment. We then discuss ongoing changes in health care coverage, including implementation of provisions of the Affordable Care Act, increasing prevalence of high-deductible health insurance plans, and factors that affect health care delivery, with a focus on vertical integration of hospitals and providers. Read More

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http://dx.doi.org/10.1200/EDBK_279951DOI Listing

Re: "Issues Faced by Senior Women Physicians: A National Survey," by Templeton K, et al. ( 2020 [Epub ahead of print]; DOI: 10.1089/jwh.2019.7910).

J Womens Health (Larchmt) 2020 May 21. Epub 2020 May 21.

Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1089/jwh.2020.8346DOI Listing

DIRECT DIELECTRIC BARRIER DISCHARGE IONIZATION PROMOTES RAPID AND SIMPLE LUBRICANT OIL FINGERPRINTING.

J Am Soc Mass Spectrom 2020 May 26. Epub 2020 May 26.

Petroleomics, which is the characterization, separation and quantification of the components of petroleum and crude oil, is an emerging area of study. However, the repertoire of analytical methods available to understand commercial automotive lubricant oils (ALOs) is very limited. Ambient mass spectrometry is one of the most sensitive analytical methods for real-time and in situ chemical analysis. Read More

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http://dx.doi.org/10.1021/jasms.0c00071DOI Listing

Parent recommendation to bank sperm among at-risk adolescent and young adult males with cancer.

Pediatr Blood Cancer 2020 May 26:e28217. Epub 2020 May 26.

Department of Psychology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: Adolescent and young adult (AYA) males newly diagnosed with cancer are often faced with making quick decisions about whether to cryopreserve ("bank") sperm prior to treatment initiation. Given that parental influence is crucial among young patients, the present study examines the prevalence of and factors associated with parent recommendation to bank sperm.

Procedure: Parents of 13- to 21-year-old males newly diagnosed with cancer and at risk for infertility secondary to impending gonadotoxic treatment completed questionnaires typically within one week of treatment initiation. Read More

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http://dx.doi.org/10.1002/pbc.28217DOI Listing

Survival After Cancer Treatment at Top-Ranked US Cancer Hospitals vs Affiliates of Top-Ranked Cancer Hospitals.

JAMA Netw Open 2020 May 1;3(5):e203942. Epub 2020 May 1.

Abramson Cancer Center, University of Pennsylvania, Philadelphia.

Importance: Hospital networks formed around top-ranked cancer hospitals represent an opportunity to optimize complex cancer care in the community.

Objective: To compare the short- and long-term survival after complex cancer treatment at top-ranked cancer hospitals and the affiliates of top-ranked hospitals.

Design, Setting, And Participants: This cohort study was conducted using data from the unabridged version of the National Cancer Database. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.3942DOI Listing

Interventions to Prevent Illicit and Nonmedical Drug Use in Children, Adolescents, and Young Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.

JAMA 2020 May;323(20):2067-2079

Kaiser Permanente Evidence-based Practice Center, Center for Health Research, Kaiser Permanente, Portland, Oregon.

Importance: Illicit and nonmedical (use in ways other than instructed) drug use is common in adolescents and young adults and increases the risk of harmful outcomes such as injuries, violence, and poorer academic performance.

Objective: To review the benefits and harms of interventions to prevent illicit and nonmedical drug use in children, adolescents, and young adults to inform the US Preventive Services Task Force.

Data Sources: MEDLINE, PubMED, PsycINFO, and the Cochrane Central Register of Controlled Trials (January 1, 2013, to January 31, 2019 [children and adolescents]; January 1, 1992, to January 31, 2019 [young adults <25 years]); surveillance through March 20, 2020. Read More

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http://dx.doi.org/10.1001/jama.2020.1432DOI Listing

Prevalence, Types, and Sources of Bullying Reported by US General Surgery Residents in 2019.

JAMA 2020 May;323(20):2093-2095

Surgical Outcomes and Quality Improvement Center (SOQIC), Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1001/jama.2020.2901DOI Listing

Effects of a Workplace Wellness Program on Employee Health, Health Beliefs, and Medical Use: A Randomized Clinical Trial.

JAMA Intern Med 2020 May 26. Epub 2020 May 26.

Department of Finance, University of Illinois at Urbana-Champaign.

Importance: Many employers use workplace wellness programs to improve employee health and reduce medical costs, but randomized evaluations of their efficacy are rare.

Objective: To evaluate the effect of a comprehensive workplace wellness program on employee health, health beliefs, and medical use after 12 and 24 months.

Design, Setting, And Participants: This randomized clinical trial of 4834 employees of the University of Illinois at Urbana-Champaign was conducted from August 9, 2016, to April 26, 2018. Read More

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http://dx.doi.org/10.1001/jamainternmed.2020.1321DOI Listing

Nonuremic Calciphylaxis.

J Clin Rheumatol 2020 Jun;26(4):e83-e84

From the American University of the Caribbean, Coral Gables, FL.

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http://dx.doi.org/10.1097/RHU.0000000000000899DOI Listing

Three Different Abnormalities in Pulmonary Arteries in Behçet.

J Clin Rheumatol 2020 Jun;26(4):e74

From the Internal Medicine Department, American University of Beirut Medical Center, Riad El Solh, Beirut, Lebanon.

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http://dx.doi.org/10.1097/RHU.0000000000000857DOI Listing

Is our Effort Appropriately Valued? An Analysis of Work Relative Value Units in Immediate Breast Reconstruction.

Plast Reconstr Surg 2020 May 21. Epub 2020 May 21.

Institute of Reconstructive Surgery, Houston Methodist Hospital, Weill Cornell Medicine, Houston, Texas, USA.

Background: The Work relative value units (wRVUs) system was developed as a quantifier of physician labor, technical skill, and training time required to complete surgical procedures. Thus, more complex surgical procedures that require greater technical skills and are more time consuming should yield a greater compensation. It is known that prosthetic breast reconstruction reimburses more per hour than autologous breast reconstruction. Read More

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http://dx.doi.org/10.1097/PRS.0000000000007054DOI Listing

Pharmacogenomics of thiopurines: distribution of TPMT and NUDT15 polymorphisms in the Brazilian Amazon.

Pharmacogenet Genomics 2020 May 22. Epub 2020 May 22.

Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro.

Reduced function alleles in the TPMT and NUDT15 genes are risk factors for thiopurine toxicity. This study evaluated the influence of Native ancestry on the distribution of TPMT (rs1142345, rs1800460 and rs1800462) and NUDT15 (rs116855232) polymorphisms and compound metabolic phenotypes in 128 healthy males from the Brazilian Amazon. The average proportion of Native and European ancestry differed greatly and significantly between self-declared Amerindians and non-Amerindians, although extensive admixture in both groups was evident. Read More

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http://dx.doi.org/10.1097/FPC.0000000000000411DOI Listing

Vertebral Osteomyelitis after Spine Surgery - A Disease with Distinct Characteristics.

Spine (Phila Pa 1976) 2020 May 21. Epub 2020 May 21.

Department 1 for Internal Medicine, University Hospital Cologne, Cologne, Germany.

Study Design: Prospective cohort study OBJECTIVE.: We aimed to determine the 2-year survival and to identify clinical and microbiological characteristics of patients with native vertebral osteomyelitis (VO) as compared to post-operative VO to find further strategies for improvement of the management of VO.

Summary Of Background Data: A relevant subgroup (20-30%) of patients with VO has a history of spine surgery. Read More

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http://dx.doi.org/10.1097/BRS.0000000000003542DOI Listing

Correlates of Google Search Rankings for Spine Surgeons: An Analysis of Academic Pedigree, Social Media Presence, and Patient Ratings.

Spine (Phila Pa 1976) 2020 May 21. Epub 2020 May 21.

Department of Neurosurgery, University of Illinois at Chicago (Chicago, IL 60612).

Study Design: Prospective observational study.

Objective: The objective of this study is to identify correlates of search ranking among academic pedigree, online ratings, and social media following.

Summary Of Background Data: Patients increasingly rely on online search in selecting healthcare providers. Read More

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http://dx.doi.org/10.1097/BRS.0000000000003567DOI Listing

Food and Drug Administration Safety Communication on the Use of Transvaginal Mesh in Pelvic Organ Prolapse Repair Surgery: The Impact of Social Determinants of Health.

Female Pelvic Med Reconstr Surg 2020 May 21. Epub 2020 May 21.

From the Department of Healthcare Policy and Research, Weill Cornell Medical College.

Objective: This study was to examine the impact of the July 2011 Food and Drug Administration (FDA) safety communication on the use of transvaginal mesh in pelvic organ prolapse (POP) repair by patients' race and ethnicity.

Methods: We conducted an observational cohort study of women undergoing POP repairs in 2008 to 2015 in New York State. We examined the changes in transvaginal mesh use in POP repairs before and after the FDA communication by patients' race and ethnicity. Read More

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http://dx.doi.org/10.1097/SPV.0000000000000863DOI Listing

Using Preventive Health Alerts in the Electronic Health Record Improves Hepatitis C Virus Testing Among Infants Perinatally Exposed to Hepatitis C.

Pediatr Infect Dis J 2020 May 20. Epub 2020 May 20.

Department of Internal Medicine, MetroHealth Medical Center, Case Western Reserve University.

Background: Perinatal exposure to hepatitis C virus (HCV) is a major public health issue, and poor testing rates leave many children with infection unidentified. We sought to use the electronic health record (EHR) to promote guideline-directed HCV testing among infants born to mothers with HCV infection in an urban, safety-net hospital system.

Methods: Our study population was identified using our EHR database, Epic. Read More

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http://dx.doi.org/10.1097/INF.0000000000002757DOI Listing

Update: AHA guidelines for CPR and emergency cardiovascular care.

Nursing 2020 Jun;50(6):58-61

In Philadelphia, Pa., Mary Patricia Day is a nurse anesthetist at Temple University Hospital; Karen Jean Craig-Brangan is an AHA Training Center manager at Temple University Health System and president and owner of EMS Educational Services, Inc. in Bensalem, Pa.

Continuous review of current research and practice has resulted in updates to the American Heart Association guidelines for CPR and emergency cardiovascular care. This article examines the recommendations and their implementation into current healthcare practice. Read More

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http://dx.doi.org/10.1097/01.NURSE.0000659320.66070.a9DOI Listing

Appropriate Use Criteria for Treatment of Pediatric Supracondylar Humerus Fractures With Vascular Injury: Do Our Hospital Practice Patterns Agree With Current Recommendations?

J Pediatr Orthop 2020 May 22. Epub 2020 May 22.

Department of Orthopaedic Surgery, Atrium Health Musculoskeletal Institute.

Background: Managing the pulseless pediatric supracondylar humerus fracture (PSHF) remains a significant clinical decision-making challenge for the treating surgeon. The purpose of the study is to determine frequency of the treatments according to the American Academy of Orthopaedic Surgeons (AAOS) Appropriate Use Criteria (AUC) for the PSHF with vascular injury and evaluate the appropriateness of these interventions.

Methods: We identified all PSHF with concern for vascular injury at one high volume, level 1 trauma center managed by 6 fellowship-trained pediatric orthopaedic surgeons over 4. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001592DOI Listing

Stepwise Safe Access in Hip Arthroscopy in the Supine Position: Tips and Pearls From A to Z.

J Am Acad Orthop Surg 2020 May 22. Epub 2020 May 22.

From American Hip Institute Research Foundation (Dr. Maldonado, Dr. Rosinsky, Dr. Shapira, and Dr. Domb), and American Hip Institute (Dr. Domb), Des Plaines, IL.

Hip arthroscopy is rapidly growing as a treatment with good outcomes for pathologic conditions such as femoroacetabular impingement syndrome and labral tears. At the same time, it is one of the most technically challenging and demanding procedures in orthopaedics with a technically demanding skill. The first challenge is to safely access the joint, which requires accurate anatomical knowledge, a strong sense of spatial orientation, and repeated practice. Read More

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http://dx.doi.org/10.5435/JAAOS-D-19-00856DOI Listing

In Vitro Antimicrobial Activity of a New Ophthalmic Solution Containing Hexamidine Diisethionate 0.05% (Keratosept).

Cornea 2020 May 25. Epub 2020 May 25.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Purpose: To assess the in vitro antimicrobial activity of a new commercial ophthalmic solution containing hexamidine diisethionate 0.05% (Keratosept).

Methods: Staphylococcus aureus American Type Culture Collection (ATCC 43300), Pseudomonas aeruginosa ATCC 27853, 3 ocular bacterial isolates (1 Staphylococcus epidermidis, 1 S. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002375DOI Listing

Emergence from the COVID-19 Pandemic and the Care of Chronic Pain: Guidance for the Interventionalist.

Anesth Analg 2020 May 21. Epub 2020 May 21.

Introduction: The current coronavirus disease (COVID-19) pandemic led to a significant disruption in the care of pain from chronic and subacute conditions. The impact of this cessation of pain treatment may have unintended consequences of increased pain, reduced function, increased reliance on opioid medications and potential increased morbidity, due to the systemic impact of untreated disease burden. This may include decreased mobility, reduction in overall health status and increase of opioid use with the associated risks. Read More

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http://dx.doi.org/10.1213/ANE.0000000000005000DOI Listing

In Reply to O'Brien.

Authors:
William T Mallon

Acad Med 2020 Jun;95(6):820-821

Senior director, Strategy and Innovation Development, Association of American Medical Colleges, Washington, DC; ORCID: https://orcid.org/0000-0003-0100-5893.

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http://dx.doi.org/10.1097/ACM.0000000000003306DOI Listing

Providing Long-acting Reversible Contraception to Adolescents: A Review.

Clin Obstet Gynecol 2020 May 22. Epub 2020 May 22.

Department of Pediatrics, Division of Child and Adolescent Health, Columbia University Irving Medical Center/New York-Presbyterian Hospital, New York, New York.

Unintended teen pregnancy continues to be a problem in the United States which has the highest rate of adolescent pregnancy among developed nations. Long-acting reversible contraception (LARC) has much higher continuation rates compared with moderately effective reversible contraception; however, moderately effective reversible contraception is more commonly used by adolescents. The American Academy of Pediatrics and the American College of Obstetricians and Gynecologists recommend LARC as first-line contraception for adolescents. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000541DOI Listing