7,235 results match your criteria American journal of hypertension[Journal]


Cross-sectional association between blood pressure status and atrial fibrillation in an elderly Chinese population.

Am J Hypertens 2019 Apr 20. Epub 2019 Apr 20.

Center for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: Atrial fibrillation(AF) and hypertension are prevalent chronic disease conditions in the elderly. In the present cross-sectional study, we investigated the association between blood pressure (BP) and AF in an elderly Chinese population.

Method: Our elderly (≥65 years) subjects were residents recruited from 6 communities in Shanghai from 2006 to 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz060DOI Listing

Response to "Carotid Flow Velocities and Endothelial Function in Cognitive Ability of Hypertension".

Am J Hypertens 2019 Apr 15. Epub 2019 Apr 15.

Center for Evidence-based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

View Article

Download full-text PDF

Source
https://academic.oup.com/ajh/advance-article/doi/10.1093/ajh
Publisher Site
http://dx.doi.org/10.1093/ajh/hpz038DOI Listing
April 2019
1 Read

High Home Blood Pressure Variability Associates With Exaggerated Blood Pressure Response to Cold Stress.

Am J Hypertens 2019 Apr 15. Epub 2019 Apr 15.

Center for Environmental and Respiratory Health Research (CERH), University of Oulu, Oulu, Finland.

Background: Exaggerated sympathetic cardiovascular (CV) reactivity to stress associates with elevated risk for clinical and preclinical end points of CV disease. It would be useful to identify these individuals, preferably from feasible measurements commonly used in health care. Our study examined the association between home blood pressure (BP) variability and cardiac workload response to whole-body cold exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz011DOI Listing

Novel contributors and mechanisms of cellular senescence in hypertension-associated premature vascular aging.

Am J Hypertens 2019 Apr 15. Epub 2019 Apr 15.

Center for Hypertension and Precision Medicine, Toledo, OH.

Hypertension has been described as a condition of premature vascular aging, relative to actual chronological age. In fact, many factors that contribute to the deterioration of vascular function as we age are accelerated in hypertension. Nonetheless, the precise mechanisms that underlie the aged phenotype of arteries from hypertensive patients and animals remain elusive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz052DOI Listing

Role of pendrin in the pathophysiology of aldosterone-induced hypertension.

Authors:
Shigeru Shibata

Am J Hypertens 2019 Apr 15. Epub 2019 Apr 15.

Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

The recent advances in genetics and molecular biology have resulted in the characterization of key components that critically regulate renal NaCl transport and blood pressure. Pendrin is a Cl-/HCO3- exchanger that is highly expressed in thyroid, inner ear, and kidney. In the kidney, it is selectively present at the apical membrane in non- intercalated cells of the connecting tubules and cortical collecting duct. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/ajh/advance-article/doi/10.1093/ajh
Publisher Site
http://dx.doi.org/10.1093/ajh/hpz054DOI Listing
April 2019
1 Read

A Novel Frameshift Mutation of SCNN1G Causing Liddle Syndrome with Normokalemia.

Am J Hypertens 2019 Apr 12. Epub 2019 Apr 12.

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Liddle syndrome (LS) is an autosomal dominant disorder caused by single-gene mutations of the epithelial sodium channel (ENaC). It is characterized by early onset hypertension, spontaneous hypokalemia and low plasma renin and aldosterone concentrations. In this study, we reported an LS pedigree with normokalemia resulting from a novel SCNN1G frameshift mutation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz053DOI Listing
April 2019
2 Reads

Serum Sodium and Pulse Pressure in SPRINT.

Am J Hypertens 2019 Apr 12. Epub 2019 Apr 12.

Division of Geriatrics, University of Utah and VA Salt Lake City Geriatric Research, Education and Clinical Center, Salt Lake City, UT.

Background: High dietary sodium intake may induce a small, yet physiologically relevant rise in serum sodium concentration, which associates with increased systolic blood pressure (SBP). Cellular data suggest that this association is mediated by increased endothelial cell stiffness. We hypothesized that higher serum sodium levels were associated with greater arterial stiffness in participants in the Systolic Blood Pressure Intervention Trial (SPRINT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz055DOI Listing
April 2019
1 Read

Telemonitoring of 24-hour Blood Pressure in Local Pharmacies and Blood Pressure Control in the Community. The Templar Project.

Am J Hypertens 2019 Apr 12. Epub 2019 Apr 12.

Section of Cardiovascular Medicine, Department of Medicine and Surgery, University of Milano-Bicocca, Milan.

Background: The analysis of ambulatory blood pressure monitorings (ABPMs) performed in 639 Italian pharmacies in the context of a telehealth-based service allowed to evaluate the level of BP control in the community.

Methods: 24-hour ABPMs were performed by a clinically validated, automated, upper-arm BP monitor. Recordings were uploaded on a certified web-based telemedicine platform (www. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz049DOI Listing
April 2019
1 Read

Daytime Napping Masks Dipping.

Authors:
Michael Bursztyn

Am J Hypertens 2019 Apr 12. Epub 2019 Apr 12.

Hypertension Unit, Department of Medicine, Hadassah-Hebrew University Medical Center, Mount-Scopus, Jerusalem, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz051DOI Listing
April 2019
1 Read

Left ventricular remodeling and masked hypertension: Don't forget nighttime diastolic blood pressure.

Am J Hypertens 2019 Apr 6. Epub 2019 Apr 6.

University of Milan-Bicocca and Istituto Auxologico Italiano IRCCS, Clinical Research Unit, Viale della Resistenza, Meda, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz047DOI Listing

Novel Metabolites Are Associated with Augmentation Index and Pulse Wave Velocity: Findings from the Bogalusa Heart Study.

Am J Hypertens 2019 Apr 6. Epub 2019 Apr 6.

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.

Background: Metabolomics study may help identify novel mechanisms underlying arterial stiffening.

Methods: We performed untargeted metabolomics profiling among 1,239 participants of the Bogalusa Heart Study. After quality control, 1,202 metabolites were evaluated for associations with augmentation index (AI) and pulse-wave velocity (PWV), using multivariate linear regression adjusting for age, sex, race, education, smoking, drinking, body weight, body height, physical activity, and estimated glomerular filtration rate. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/ajh/advance-article/doi/10.1093/ajh
Publisher Site
http://dx.doi.org/10.1093/ajh/hpz046DOI Listing
April 2019
1 Read

Renin and antihypertensive drug therapy in African ancestry patients.

Am J Hypertens 2019 Apr 4. Epub 2019 Apr 4.

Dpt. of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam. The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz045DOI Listing

Orthostatic hypotension and falls.

Authors:
Shih-Wei Lai

Am J Hypertens 2019 Apr 4. Epub 2019 Apr 4.

College of Medicine, China Medical University, Taichung, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz044DOI Listing
April 2019
1 Read

Increased Blood Pressure Variability: A Marker of Augmented Sympathetic Vascular Reactivity?

Authors:
Teemu J Niiranen

Am J Hypertens 2019 Mar 31. Epub 2019 Mar 31.

Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz030DOI Listing

Pancreatic AT1aR Deficiency Decreases Insulin Secretion in Obese C57BL/6 Mice.

Am J Hypertens 2019 Mar 22. Epub 2019 Mar 22.

Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY.

Background: Previously, we demonstrated that obese mice have marked elevations in systemic concentrations of angiotensin II (AngII). Drugs that inhibit the renin-angiotensin system (RAS), including angiotensin type 1 receptor (AT1R) antagonists, have been reported to delay the onset of type 2 diabetes (T2D), suggesting improvements in insulin sensitivity or regulation of pancreatic insulin secretion. Pancreatic islets possess components of the RAS, including AT1R, but it is unclear if AngII acts at islets to regulate insulin secretion during the development of T2D. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz042DOI Listing

Diastolic reverse dipping pattern is the predictor for the echocardiographic changes in the untreated masked hypertensive patients.

Am J Hypertens 2019 Mar 21. Epub 2019 Mar 21.

Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou China.

Background: The prognostic value of the dipping categories of diastolic blood pressure (DBP) is unknown. This study aimed to investigate the association between DBP dipping categories of diastolic blood pressure and echocardiographic changes in untreated masked hypertension (MH) patients.

Methods: This retrospective study included 721 untreated MH patients between June 2006 and June 2016. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/ajh/advance-article/doi/10.1093/ajh
Publisher Site
http://dx.doi.org/10.1093/ajh/hpz041DOI Listing
March 2019
3 Reads

Non-invasive assessment of myocardial perfusion in different blood pressure phenotypes and its association with arterial stiffness indices.

Am J Hypertens 2019 Mar 16. Epub 2019 Mar 16.

3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: We investigated for the first time whether patients with recent-onset, uncomplicated hypertension and different hypertension phenotypes exhibit altered values of SEVR, a surrogate measure of myocardial perfusion that correlates with the ratio of subendocardial to subepicardial blood flow. We additionally explored whether SEVR correlates with arterial stiffness in a population free from the long-term effects of essential hypertension.

Methods: Non-treated individuals free from any known health problems were classified as true hypertensives (TH), white-coat hypertensives (WCH), masked hypertensives (MH) and normotensives. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz039DOI Listing
March 2019
1 Read

Burden, Access, and Disparities in Kidney Disease.

Am J Hypertens 2019 Mar;32(4):433-439

Nephrology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz007DOI Listing

Chronic treatment with acetylcholinesterase inhibitors attenuates vascular dysfunction in spontaneously hypertensive rats.

Am J Hypertens 2019 Mar 15. Epub 2019 Mar 15.

Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Background: Acetylcholinesterase inhibition prevents autonomic imbalance, reduces inflammation and attenuates the development of hypertension. Considering that vascular dysfunction is a crucial feature of arterial hypertension, we investigated the effects of chronic administration of acetylcholinesterase inhibitors - pyridostigmine or donepezil - on vascular reactivity of spontaneously hypertensive rats (SHR).

Methods: Endothelium-dependent relaxant responses to acetylcholine and contractile responses induced by electric field stimulation (EFS) and alpha-adrenergic agonist were studied in mesenteric resistance arteries from SHR and Wistar Kyoto rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz036DOI Listing

Title: Familial Hypercholesterolemia with coexisting renovascular stenosis and premature coronary artery disease.

Am J Hypertens 2019 Mar 14. Epub 2019 Mar 14.

Monash Cardiovascular Research Centre, MonashHEART, Monash Health, Monash University, Melbourne, Australia.

Familial hypercholesterolemia (FH) is a common hereditary lipid disorder associated with substantial risk of premature atherosclerotic cardiovascular disease (ASCVD). We report an interesting newly diagnosed index case of FH in a 31 year old man who presented to the hospital with a ST-elevated myocardial infarction (STEMI). He had a background of inadequately treated hypertension and hypercholesterolemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz037DOI Listing
March 2019
1 Read
2.852 Impact Factor

Age-Associated Differences in Central Artery Responsiveness to Sympathoexcitatory Stimuli.

Am J Hypertens 2019 Mar 11. Epub 2019 Mar 11.

Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, Iowa.

Background: Age-associated arterial stiffening may be the result of greater tonic sympathetic nerve activity. However, age-associated changes in central artery responsiveness to sympathoexcitatory stimuli are understudied. Therefore, we examined changes in central-artery stiffness and wave reflection in response to sympathoexcitatory stimuli in young and older adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz035DOI Listing

Early Life Microcirculatory Plasticity and Blood Pressure Changes in Low Birth Weight Infants Born to Normotensive Mothers: A Cohort Study.

Am J Hypertens 2019 Mar 1. Epub 2019 Mar 1.

Molecular and Clinical Sciences Research Institute, St George's, University of London.

Background: Capillary rarefaction (CR) is an established hallmark of essential hypertension (EH). The aim of this study was to examine early changes in capillary density (CD) and blood pressure (BP) in low birth weight (LBW) infants who are at risk of developing EH in later life.

Methods: We studied 77 LBW infants and 284 normal birth weight (NBW) infants, all born to normotensive mothers in a longitudinal multi-centre study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz034DOI Listing
March 2019
5 Reads

In the deep end of dipping: Nocturnal blood pressure fall and surrogate cardiovascular risk markers in individuals with optimal 24h blood pressure.

Am J Hypertens 2019 Mar 1. Epub 2019 Mar 1.

3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz033DOI Listing

Carotid Flow Velocities and Endothelial Function in Cognitive Ability of Hypertension.

Authors:
Kazushi Tsuda

Am J Hypertens 2019 Feb 28. Epub 2019 Feb 28.

Cardiovascular and Metabolic Research Center, Kansai University of Health Sciences, Osaka, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz032DOI Listing
February 2019

Subclinical Primary Aldosteronism and Cardiometabolic Disorders.

Authors:
E Victor Adlin

Am J Hypertens 2019 Feb 26. Epub 2019 Feb 26.

Section of Endocrinology, Diabetes and Metabolism Lewis Katz School of Medicine at Temple University, Philadelphia, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz031DOI Listing
February 2019

Prognostic value of the estimated glomerular filtration rate decline in hypertensive patients without chronic kidney disease.

Am J Hypertens 2019 Feb 22. Epub 2019 Feb 22.

CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.

Background: Our objective of this study was to determine if rate of eGFR decline and its intensity was associated with cardiovascular risk and death in hypertensive patients whose baseline estimated glomerular filtration rate (eGFR) was higher than 60 mL/min/1.73m2.

Methods: This study comprised 2,516 hypertensive patients who had had at least two serum creatinine measurements over a four-year period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz029DOI Listing
February 2019
1 Read

Association between community-level social participation and self-reported hypertension in older Japanese: A JAGES multilevel cross-sectional study.

Am J Hypertens 2019 Feb 22. Epub 2019 Feb 22.

Center for Preventive Medical Sciences, Chiba University, Inohana, Chuo-ku, Chiba, Japan.

Background: Many factors are associated with hypertension development. We focused on social participation as an aspect of social capital and investigated the contextual relationship between community-level social participation and hypertension using multilevel regression analyses.

Methods: We used cross-sectional data from the 2016 Japan Gerontological Evaluation Study-a population-based study of functionally independent adults aged 65 years or older. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz028DOI Listing
February 2019
1 Read

Too Much Sugar Is Not Good for the Fetus.

Authors:
Bonita Falkner

Am J Hypertens 2019 Mar;32(4):329-330

Thomas Jefferson University, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz025DOI Listing
March 2019
1 Read

Maternal blood pressure, cord glucocorticoids, and child neurodevelopment at 2 years of age: a birth cohort study.

Am J Hypertens 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background: Pregnancy hypertensive disorders have impaired neurodevelopment in offspring. We aimed to explore the association of normal range maternal blood pressure (BP) with child neurodevelopment, as well as the possible role of placental 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2) therein.

Methods: Among 1,008 mother-child pairs recruited in Wuhan, China, in 2013-2015, we measured maternal third-trimester BP (systolic and diastolic BP, SBP and DBP) and cord glucocorticoids (cortisol and cortisone), a marker reflecting placental 11β-HSD2 activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz024DOI Listing
February 2019
1 Read

Nondipping Pattern and Cardiovascular and Renal Damage in a Population-Based Study (The Stanislas Cohort Study).

Am J Hypertens 2019 Feb 7. Epub 2019 Feb 7.

FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.

Objective: The attenuation of physiological nocturnal decline of blood pressure (BP) - called nondipper pattern - has previously been reported to be associated with target organ damage in hypertensive subjects. However, this association remains debated and poorly studied in normotensive patients. The present study aimed to investigate the association between nondipper pattern and subclinical cardiovascular and renal damage in an initially healthy population-based cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz020DOI Listing
February 2019
13 Reads

The Aldosterone/Renin Ratio predicts cardiometabolic disorders in subjects without classic primary aldosteronism.

Am J Hypertens 2019 Feb 9. Epub 2019 Feb 9.

Department of Endocrinology, School of Medicine, Pontificia Universidad Católica de Chile. Avda Libertador Bernardo O´Higgins, Santiago Centro, Santiago, Chile.

Background: Aldosterone has been linked with obesity, metabolic syndrome (MetS), pro-inflammatory and pro-thrombotic states; however, most studies relate these indicators with primary aldosteronism (PA), excluding non-PA patients.

Objective: To determine whether aldosterone, renin or the plasma aldosterone/renin ratio (ARR) are associated with metabolic disorders and inflammatory/vascular biomarkers in a non-PA population.

Methods: We studied 275 patients including adolescents and adults of both genders and measured plasma and urinary aldosterone and determined the plasma renin activity (PRA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz023DOI Listing
February 2019
1 Read

Plasma Renin Activity Is a Predictive Biomarker of Blood Pressure Response in European but not in African Americans With Uncomplicated Hypertension.

Am J Hypertens 2019 Feb 9. Epub 2019 Feb 9.

Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, FL.

Background: Inter-individual variability in blood pressure (BP) response to antihypertensives has been reported. Although plasma renin activity (PRA) is a potential biomarker for personalizing antihypertensive therapy in European-American (EA) and African-American (AA) hypertensives, clinical utility of PRA-guided prescribing is incompletely understood.

Methods: sing systematic-phased-approach, PRA's clinical utility was assessed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz022DOI Listing
February 2019
6 Reads

β1-adrenoceptor polymorphisms and blood pressure: 49S variant increases plasma renin but not blood pressure in hypertensive patients.

Am J Hypertens 2019 02 11. Epub 2019 Feb 11.

Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, United Kingdom.

Background: Activation of beta-1 adrenoreceptors (β1-AR) in the kidney releases renin that plays a major role in the maintenance of blood pressure. Genetic variation in the β1-AR could therefore alter the physiological and clinical effects of this hormone. We tested this hypothesis in patients from a primary care cohort being screened for primary hyperaldosteronism, PHA (n=465). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz019DOI Listing
February 2019
3 Reads

Health behaviors, nocturnal hypertension and non-dipping blood pressure: The Coronary Artery Risk Development in Young Adults and Jackson Heart Study.

Am J Hypertens 2019 Feb 2. Epub 2019 Feb 2.

University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: Several health behaviors have been associated with hypertension based on clinic blood pressure (BP). Data on the association of health behaviors with nocturnal hypertension and non-dipping systolic BP (SBP) are limited.

Methods: We analyzed data for participants with ambulatory BP monitoring (ABPM) at the Year 30 Coronary Artery Risk Development in Young Adults (CARDIA) study exam in 2015-2016 (n=781) and the baseline Jackson Heart Study (JHS) exam in 2000-2004 (n=1,046). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz017DOI Listing
February 2019
33 Reads
2.852 Impact Factor

Dysregulation of HDAC9 represses trophoblast cell migration and invasion through TIMP3 activation in preeclampsia.

Am J Hypertens 2019 Feb 2. Epub 2019 Feb 2.

Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

Background And Objective: Preeclampsia (PE) is a common disease during pregnancy. It is generally accepted that PE is closely associated with shallow placenta implantation caused by the dysfunction of trophoblast cells. Trophoblasts have been recognized to share histological and behavioral characteristics with cancer cells, and many lines of evidence have emphasized that histone deacetylases (HDACs) are therapeutic targets for cancer treatment with the most promising. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz006DOI Listing
February 2019
1 Read
2.852 Impact Factor

Molecular and Cellular Effect of Angiotensin 1-7 on Hypertensive Kidney Disease.

Am J Hypertens 2019 Jan 29. Epub 2019 Jan 29.

Division of Cardiovascular Diseases Department of Medicine University of Tennessee Health Science Center Memphis, Tennessee.

Background: Studies implicate that Ang1-7 imparts protective effects in the kidney. However, its relevance in hypertensive kidney disease is not fully understood. The purpose of this study is to explore the role of Ang1-7 on renal damage/remodeling during hypertension and its potential underlying molecular-cellular mechanisms. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/ajh/advance-article/doi/10.1093/ajh
Publisher Site
http://dx.doi.org/10.1093/ajh/hpz009DOI Listing
January 2019
4 Reads

Tissue transglutaminase-mediated AT1 receptor sensitization underlies pro-inflammatory cytokine LIGHT-induced hypertension.

Am J Hypertens 2019 Feb 2. Epub 2019 Feb 2.

Department of Biochemistry and Molecular Biology, University of Texas McGovern Medical School at Houston.

Background: Although numerous recent studies have shown a strong link between inflammation and hypertension, the underlying mechanisms by which inflammatory cytokines induce hypertension remain to be fully elucidated. Hypertensive disorders are also associated with elevated pressor sensitivity. Tissue transglutaminase (TG2), a potent crosslinking enzyme, is known to be transcriptionally activated by inflammatory cytokines and stabilize angiotensin II (Ang II) receptor AT1 (AT1R) via ubiquitination-preventing posttranslational modification. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz018DOI Listing
February 2019
1 Read
2.852 Impact Factor

Association of Orthostatic Hypotension Timing with Clinical Events in Adults with Diabetes and Hypertension: Results from the ACCORD Trial.

Am J Hypertens 2019 Jan 31. Epub 2019 Jan 31.

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Objective: To determine the effects of orthostatic hypotension (OH) measurement timing on its associations with dizziness, falls, fractures, CVD, and mortality.

Methods: We analyzed OH measurements from the ACCORD BP trial, which evaluated two BP goals (systolic BP [SBP]<120mmHg versus SBP<140mmHg) and incident cardiovascular disease (CVD) among adults with diabetes and hypertension. Seated BP was measured after 5 minutes of rest at baseline and follow-up visits (12-month, 48-month, and exit). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz015DOI Listing
January 2019

Dapagliflozin Attenuates Cardiac Remodeling in Mice Model of Cardiac Pressure Overload.

Am J Hypertens 2019 Jan 25. Epub 2019 Jan 25.

Department of Cardiology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: Dapagliflozin (DAPA) is an inhibitor of sodium-glucose cotransporter 2 (SGLT2) prescribed for type 2 diabetes mellitus (T2DM). DAPA plays a protective role against cardiovascular diseases. Nevertheless, the effect and mechanism of DAPA on pressure overload-induced cardiac remodeling has not been determined. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/ajh/advance-article/doi/10.1093/ajh
Publisher Site
http://dx.doi.org/10.1093/ajh/hpz016DOI Listing
January 2019
12 Reads

Amplified Association Between Blood Pressure and Albuminuria in Overweight Patients with Biopsy-Proven Hypertensive Nephrosclerosis.

Am J Hypertens 2019 Jan 26. Epub 2019 Jan 26.

Department of Nephrology and Laboratory Medicine, Kanazawa University, Takara-machi, Kanazawa, Ishikawa, Japan.

Background: An overweight person is at high risk for hypertensive renal damage. The effect of weight on the association between systolic blood pressure (SBP) and albuminuria remains unknown in patients with histologically diagnosed hypertensive nephrosclerosis.

Methods: A total of 97 patients with biopsy-confirmed hypertensive nephrosclerosis were recruited from 13 centers throughout Japan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz010DOI Listing
January 2019
3 Reads

The risk of hypertension doubles every ten years in China: Age, period and birth cohort effects on the prevalence of hypertension from 2004 to 2013.

Am J Hypertens 2019 Jan 19. Epub 2019 Jan 19.

Department of Epidemiology, School of Basic Medicine, Jinan University, Guangzhou, Guangdong, China.

Background: Hypertension is a growing problem worldwide and can often result in a variety of negative health outcomes. The aim of this study was to assess the effects of age at diagnosis, calendar period, and birth cohort on the change in the prevalence rate of hypertension in Guangzhou from 2004 to 2013.

Methods: We utilized data from the Guangzhou Community Health Survey (GCHS), a population-based study designed by the National Health and Family Planning Commission of the PRC every five years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz003DOI Listing
January 2019
3 Reads

Schedules for Self-monitoring Blood Pressure: A Systematic Review.

Am J Hypertens 2019 Mar;32(4):350-364

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: Self-monitoring of blood pressure better predicts prognosis than clinic measurement, is popular with patients, and endorsed in hypertension guidelines. However, there is uncertainty over the optimal self-monitoring schedule. We therefore aimed to determine the optimum schedule to predict future cardiovascular events and determine "true" underlying blood pressure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpy185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420684PMC
March 2019
1 Read

Impacts of the New 2017 ACC/AHA Hypertension Guideline on the Prevalence of Brachial Hypertension and Its Concordance with Central Hypertension.

Am J Hypertens 2019 Mar;32(4):409-417

Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan.

Objectives: The 2017 American College of Cardiology/American Heart Association (ACC/AHA) guideline lowers the blood pressure (BP) thresholds for defining brachial hypertension. We therefore aimed to investigate how the new guideline influences the prevalence of brachial hypertension and whether it improves the identification of central hypertension in an Asian national representative population.

Methods: A total of 2,742 adults older than 19 years participated in the 2013-2016 National Nutrition and Health Survey in Taiwan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz008DOI Listing
March 2019
8 Reads

Maternal Gestational Diabetes Is Associated With Offspring's Hypertension.

Am J Hypertens 2019 Mar;32(4):335-342

Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.

Objective: Several studies assessed maternal gestational diabetes mellitus (GDM) with the risk of childhood high blood pressure, and the results were inconsistent. We investigated the association between maternal GDM and hypertension risk in offspring during early childhood.

Methods: We performed a large study in 1,156 mother-child pairs (578 GDM and 578 non-GDM matched by their offspring's age and sex). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420681PMC
March 2019
35 Reads
2.852 Impact Factor

Added Value of Aortic Pulse Wave Velocity Index in a Predictive Diagnosis Decision Tree of Coronary Heart Disease.

Am J Hypertens 2019 Mar;32(4):375-383

Paris-Descartes University, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

Background: Coronary heart disease (CHD) is among the main causes of death in the world. Individual study of cardiovascular risk is an important way to predict CHD risk. The aim of this study was to evaluate the added role of the aortic pulse wave velocity (PWV) index in the prediction of CHD risk. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/ajh/advance-article/doi/10.1093/ajh
Publisher Site
http://dx.doi.org/10.1093/ajh/hpz004DOI Listing
March 2019
4 Reads

Serum Lipids and Risk of Rapid Renal Function Decline in Treated Hypertensive Adults With Normal Renal Function.

Am J Hypertens 2019 Mar;32(4):393-401

Division of Nephrology, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: We aim to evaluate the effect of different lipids parameters, including triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), the TG to HDL-C (TG:HDL-C) ratio, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C), on the risk of rapid renal function decline and examine any possible effect modifiers in general hypertensive patients with normal renal function.

Methods: A total of 12,549 hypertensive patients with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 in the renal sub-study of the China Stroke Primary Prevention Trial were included in the analyses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz001DOI Listing
March 2019
15 Reads

How Many Measurements?

Am J Hypertens 2019 Mar;32(4):327-328

Lauder Family Cardiovascular Center, Icahn School of Medicine at Mount Sinai, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpz002DOI Listing
March 2019
1 Read

Assessing the Impact of Patient-Centered Medical Home Principles on Hypertension Outcomes Among Patients of HRSA-Funded Health Centers.

Am J Hypertens 2019 Mar;32(4):418-425

Department of Health and Human Services, Bureau of Primary Health Care, Health Resources and Services Administration, Rockville, Maryland, USA.

Background: Millions of Americans have uncontrolled hypertension and are low-income or uninsured populations. Health Resources and Services Administration-funded health centers (HCs) are primary providers of care to these patients and a majority have adopted the patient-centered medical home (PCMH). PCMH includes principles of care coordination or integration and care management-support important to the treatment of hypertension. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpy198DOI Listing
March 2019
13 Reads

Towards Individualized Blood Pressure Management After Stroke.

Am J Hypertens 2019 Feb;32(3):242-244

Division of Neurocritical Care & Emergency Neurology and Vascular Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpy192DOI Listing
February 2019
1 Read

The Interaction of a Diabetes Gene Risk Score With 3 Different Antihypertensive Medications for Incident Glucose-level Elevation.

Am J Hypertens 2019 Mar;32(4):343-349

Department of Epidemiology, University of Kentucky College of Public Health, Lexington, Kentucky, USA.

Background: Elevations of fasting glucose (FG) levels are frequently encountered in people treated with thiazide diuretics. The risk is lower in people treated with ACE inhibitors (ACEi). To determine if genetic factors play a role in FG elevation, we examined the interaction of a diabetes gene risk score (GRS) with the use of 3 different antihypertensive medications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajh/hpy199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420683PMC
March 2019
1 Read