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    7091 results match your criteria American journal of hypertension[Journal]

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    Longitudinal Associations of Neighborhood Crime and Perceived Safety with Blood Pressure: The Multi-Ethnic Study of Atherosclerosis (MESA).
    Am J Hypertens 2018 Apr 20. Epub 2018 Apr 20.
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
    Background: High neighborhood crime and low perceptions of safety may influence blood pressure through chronic stress. Few studies have examined these associations using longitudinal data.

    Methods: We used longitudinal data from 528 participants of the Multi-Ethnic Study of Atherosclerosis (aged 45-84, non-hypertensive at baseline) who lived in Chicago, Illinois. Read More

    The Associations between Mental Health Status, Hypertension, and Hospital Inpatient Visits in Women in the U.S.
    Am J Hypertens 2018 Apr 20. Epub 2018 Apr 20.
    Virginia Commonwealth University, School of Medicine, Division of Epidemiology, Department of Family Medicine and Population Health, Richmond, VA, U.S.A.
    Background: Poor mental health status is more prevalent in women and may be related to poor hypertension outcomes and increased hospital inpatient visits. This study aims to find the association between mental health status and hypertension in women and the combined effect of mental health status and hypertension on hospital inpatient visits in women in the U. S. Read More

    A Comparison of the Diagnostic Accuracy of Common Office Blood Pressure Monitoring Protocols.
    Am J Hypertens 2018 Apr 20. Epub 2018 Apr 20.
    Center for Behavioral Cardiovascular Health, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
    Background: The optimal approach to measuring office blood pressure (BP) is uncertain. We aimed to compare BP measurement protocols that differed based on numbers of readings within and between visits and by assessment method.

    Methods: We enrolled a sample of 707 employees without known hypertension or cardiovascular disease, and obtained 6 standardized BP readings during each of 3 office visits at least 1 week apart, using mercury sphygmomanometer and BpTRU oscillometric devices (18 readings per participant) for a total of 12,645 readings. Read More

    Visit-to-visit Variability of Blood Pressure is Associated with Hospitalization and Mortality in an Unselected Adult Population.
    Am J Hypertens 2018 May 31. Epub 2018 May 31.
    University of North Dakota School of Medicine and the Health Sciences.
    Background: Blood pressure variability has been associated with poor health outcomes in high-risk patients, but its association in more general populations is poorly understood.

    Methods: We analyzed outcomes from 240,622 otherwise unselected patients who had 10 or more outpatient blood pressure readings recorded over a three-year period and were ages 20 to 100 years.

    Results: Whether calculated as SD, average change, or greatest change and systolic or diastolic blood pressure, we found that higher outpatient blood pressure variability was associated with subsequent hospitalization and mortality. Read More

    The Orphan Receptor GPR35 Contributes to Angiotensin II-Induced Hypertension and Cardiac Dysfunction in Mice.
    Am J Hypertens 2018 May 31. Epub 2018 May 31.
    Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
    Background: The orphan receptor G protein-coupled receptor 35 (GPR35) has been associated with a range of diseases, including cancer, inflammatory bowel disease, diabetes, hypertension, and heart failure. To assess the potential for GPR35 as a therapeutic target in cardiovascular disease, this study investigated the cardiovascular phenotype of a GPR35 knockout mouse under both basal conditions and following pathophysiological stimulation.

    Methods: Blood pressure was monitored in male wild-type and GPR35 knockout mice over 7-14 days using implantable telemetry. Read More

    Association Between Change in Central Nocturnal Blood Pressure and Urine Albumin-Creatinine Ratio by a Valsartan/Amlodipine Combination: A CPET Study.
    Am J Hypertens 2018 May 30. Epub 2018 May 30.
    Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.
    Background: We aimed to assess the association of changes in brachial or central nocturnal systolic blood pressure (SBP) with change in urine albumin-creatinine ratio (UACR) by a valsartan/amlodipine combination (80/5 mg) therapy in hypertensive patients.

    Methods: Twenty-three patients (age range, 47-78 years; mean, 68.0 years; 35% men, 65% with chronic kidney disease) with clinic brachial BP ≥140/90 mm Hg were treated with valsartan/amlodipine combination therapy for 16 weeks. Read More

    Circulating MicroRNAs Implicate Multiple Atherogenic Abnormalities in the Long-Term Cardiovascular Sequelae of Preeclampsia.
    Am J Hypertens 2018 May 23. Epub 2018 May 23.
    Department of Medicine, Division of General Internal Medicine, McGill University Health Centre, Montreal, Quebec, Canada.
    Background: Women who have had preeclampsia (PE) are at increased risk for premature cardiovascular disease (CVD). The underlying pathophysiology of this risk remains unclear, but potentially involves subclinical vascular damage or dysfunction. Alterations in the levels of circulating microRNAs may be implicated, as they are known to play pervasive roles in vascular biology. Read More

    Hypertension induced Morphological and Physiological Changes in Cells of the Arterial Wall.
    Am J Hypertens 2018 May 17. Epub 2018 May 17.
    Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA.
    Morphological and physiological changes in the vasculature have been described in the evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction may present itself as a contributing, or consequential factor, to vascular remodeling caused by chronically elevated systemic arterial blood pressure. Changes in all vessel layers, from the endothelium to the perivascular adipose tissue, have been described. Read More

    Circulating dp-ucMGP is Associated with Kidney Dysfunction and Arterial Stiffness.
    Am J Hypertens 2018 May 17. Epub 2018 May 17.
    Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA.
    Background: Large artery stiffening is increased in advanced CKD, but likely develops progressively in earlier stages of CKD. Active matrix Gla-Protein (MGP) is a potent vitamin-K dependent inhibitor of vascular calcification. A recent animal model demonstrated intrinsic abnormalities in vitamin K metabolism even in early CKD, but whether early human CKD is associated with vascular vitamin K deficiency is unknown. Read More

    Maternal Weight, Snoring and Hypertension; Potential Pathways of Associations.
    Am J Hypertens 2018 May 18. Epub 2018 May 18.
    Sleep Disorders Center, Department of Neurology, University of Michigan, Ann Arbor, MI.
    Background: Hypertensive disorders of pregnancy (HDP) are linked to excessive maternal weight and frequent snoring. However, pathways between maternal excessive weight, pregnancy-onset snoring and HDP are only partially estimated. We examined and quantified the total and direct associations between excessive maternal weight and incident HDP and their indirect pathway through pregnancy-onset snoring. Read More

    The Role Of Angiogenesis Inhibitors In Hypertension. Following "Ariadne's Thread".
    Am J Hypertens 2018 May 17. Epub 2018 May 17.
    Hypertension and Cardiovascular Research Clinic, Veterans Affairs and Georgetown University Medical Centers, Washington DC, USA.
    Arterial hypertension (HT) is one of the most frequently recorded comorbidities among patients under antiangiogenic therapy. Inhibitors of vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFR) are most commonly involved in new onset or exacerbation of pre-existing controlled HT. From the pathophysiology point of view, data support that reduced nitric oxide release and sodium and fluid retention, microvascular rarefaction, elevated vasoconstrictor levels and globular injury might contribute to HT. Read More

    Patient Barriers and Facilitators to Ambulatory and Home Blood Pressure Monitoring: A Qualitative Study.
    Am J Hypertens 2018 May 18. Epub 2018 May 18.
    Center for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, New York, USA.
    Background: Guidelines recommend that patients with newly elevated office blood pressure undergo ambulatory blood pressure monitoring (ABPM) or home blood pressure monitoring (HBPM) to rule-out white coat hypertension before being diagnosed with hypertension. We explored patients' perspectives of the barriers and facilitators to undergoing ABPM or HBPM.

    Methods: Focus groups were conducted with twenty English- and Spanish-speaking individuals from underserved communities in New York City. Read More

    Sleep Disorders, Including Sleep Apnea, and Hypertension.
    Am J Hypertens 2018 May 17. Epub 2018 May 17.
    Adelaide Institute for Sleep Health: A Flinders Centre for Research Excellence, College of Medicine & Public Health, Bedford Park, SA, Australia.
    There is mounting evidence for an association between sleep disorders and hypertension. In obstructive sleep apnea (OSA) there are plausible biological reasons for the development of hypertension, and treatment of OSA results in modest (2-3 mmHg), adherence-dependent decreases in blood pressure (BP), with larger effects evident in those with resistant hypertension. However, prospective, population-based cohort studies have not yet convincingly demonstrated a link between OSA and incident hypertension, and adequately powered controlled trials of CPAP for the prevention or treatment or hypertension are lacking. Read More

    Optimal Blood Pressure in Elderly Hypertensive Subjects: A Korean National Health Insurance Service Health Examinee Cohort Study.
    Am J Hypertens 2018 May 15. Epub 2018 May 15.
    Cardiology Division, Severance Cardiovascular Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Republic of Korea.
    Background: To describe the association between mean blood pressure (BP) and clinical outcomes and to investigate the optimal BP in elderly hypertensive subjects.

    Methods: This study used the National Health Insurance Service health examinee sample cohort. Subjects aged >60 years with a new diagnosis of hypertension from 2003 to 2006 were selected. Read More

    Blockade of TLR4 within the Paraventricular Nucleus Attenuates Blood Pressure by Regulating ROS and Inflammatory Cytokines in Prehypertensive Rats.
    Am J Hypertens 2018 May 15. Epub 2018 May 15.
    Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences; Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education; Xi'an Jiaotong University, Xi'an, China.
    Background: Toll like receptor 4 (TLR4) has been implicated in the progression of cardiovascular disease, including hypertension. However, the role of TLR4 in the development of prehypertension is uncertain.

    Methods: Prehypertensive rats were treated with 8% salt for 12 weeks to induce prehypertension. Read More

    Significance of an Increase in Diastolic Blood Pressure during a Stress Test in Terms of Comorbidities and Long-term Total and CV Mortality.
    Am J Hypertens 2018 May 15. Epub 2018 May 15.
    Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
    Background: A decrease in diastolic blood pressure (DBP) with exercise is considered normal, but the significance of an increase in DBP has not been validated. Our aim was to determine the relationship of DBP increasing on a stress test regarding comorbidities and mortality.

    Methods: Our database was reviewed from 1993-2010 using the first stress test of a patient. Read More

    Impact of Blunted Nocturnal Blood Pressure Dipping on Cardiac Systolic Function in Community Participants Not Receiving Anti-hypertensive Therapy.
    Am J Hypertens 2018 May 4. Epub 2018 May 4.
    Cardiovascular Pathophysiology and Genomics Research Unit, Schools of Physiology, University of the Witwatersrand, Johannesburg, South Africa.
    Background: Blunted nocturnal blood pressure (BP) dipping (non-dipping) predicts cardiovascular morbidity and mortality, and is associated with heart failure (HF) independent of office BP. Whether non-dipping is independently associated with cardiac systolic function prior to the development of HF is uncertain.

    Methods: We assessed whether nocturnal BP dipping pattern and nocturnal BP were associated with indexes of cardiac systolic function [endocardial fractional shortening (endFS), midwallFS (mFS), ejection fraction (EF)] independent of left ventricular mass index (LVMI) and relative wall thickness (RWT) in 491 randomly selected community participants not receiving anti-hypertensive therapy. Read More

    Renal Protective Effects of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) in Obese Rats on a High-Salt Diet.
    Am J Hypertens 2018 May 2. Epub 2018 May 2.
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
    Background: Obesity is a public health problem, associated with salt sensitive hypertension, kidney inflammation, and fibrosis. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a tetra peptide with anti-inflammatory and anti-fibrotic properties. However, its effect on preventing kidney damage in obesity is unknown. Read More

    Determinants of Uncontrolled Hypertension in Rural Communities in South Asia - Bangladesh, Pakistan, and Sri Lanka.
    Am J Hypertens 2018 Apr 26. Epub 2018 Apr 26.
    Program in Health Services & Systems Research, Duke-NUS Medical School, Singapore.
    Background: Uncontrolled blood pressure (BP) is a leading risk factor for death and disability in South Asia. We aimed to determine the cross-country variation, and the factors associated with uncontrolled BP among adults treated for hypertension in rural South Asia.

    Methods: We enrolled 1718 individuals aged ≥40 years treated for hypertension in a cross-sectional study from rural communities in Bangladesh, Pakistan, and Sri Lanka. Read More

    Aortic Pulse Pressure Does Not Adequately Index Cardiovascular Risk Factor-Related Changes in Aortic Stiffness and Forward Wave Pressure.
    Am J Hypertens 2018 Apr 19. Epub 2018 Apr 19.
    Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
    Background: Through the impact of conventional risk factors on arteries, several changes in aortic function contribute to cardiovascular events. It is nevertheless uncertain whether these effects are accurately reflected by changes in central aortic pulse pressure (PPc). We therefore aimed to determine the extent to which relations between modifiable risk factors and aortic function translate into increases in PPc. Read More

    MRI and Neuropsychological Correlates in African Americans with Hypertension and left vEntricular Hypertrophy.
    Am J Hypertens 2018 Apr 17. Epub 2018 Apr 17.
    Wayne State University, Detroit, Michigan, USA.
    Background: African Americans (AA) are at high risk for hypertension (HTN) and poor blood pressure (BP) control. Persistently elevated BP contributes to cardiovascular morbidity. White matter hyperintensities (WMH) are a definable magnetic resonance imaging (MRI) marker of cerebrovascular injury linked to impairments in higher level thinking (i. Read More

    Prognostic Value of Electrocardiographic Left Ventricular Hypertrophy on Cardiovascular Risk in a Non-hypertensive Community-based Population.
    Am J Hypertens 2018 Apr 6. Epub 2018 Apr 6.
    Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
    Background: The appearance of left ventricular hypertrophy on 12-lead electrocardiography (ECG-LVH) has been clarified to be associated with the risk of incidence of cardiovascular events (CVEs) in hypertensive individuals and the general population, but not enough in non-hypertensive individuals.

    Methods: A total of 4,927 non-hypertensive individuals ≥ 40 years of age who were free of CVE in the general population were followed for the incidence of CVE. ECG-LVH was defined according to criteria of the Sokolow-Lyon (SL) voltage, Cornell voltage (CV), or Cornell voltage product (CP). Read More

    The Childhood Role in Development of Primary Hypertension.
    Am J Hypertens 2018 Jun;31(7):762-769
    Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA.
    Primary hypertension is not just an adult disorder. Current US population data on children and adolescents demonstrate a prevalence of elevated blood pressure (BP) and hypertension combined of over 10%. Recent reports from prospective cohort studies describe an association of high BP in childhood with hypertension in young adulthood. Read More

    Inactive Matrix Gla Protein, Arterial Stiffness, and Endothelial Function in African American Hemodialysis Patients.
    Am J Hypertens 2018 May;31(6):735-741
    Georgia Prevention Institute, Department of Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
    Background: Matrix Gla protein (MGP) is a vascular calcification inhibitor dependent upon vitamin K for activation. Evidence suggests that elevated plasma inactive MGP levels (desphospho-uncarboxylated MGP, dp-ucMGP; indicating poorer vascular vitamin K status) are associated with greater cardiovascular disease (CVD) risk. Despite African Americans experiencing highest rates of kidney failure and CVD events, relationships between dp-ucMGP and CVD risk markers have not been examined in this population. Read More

    Risk Factors for Orthostatic Hypotension: Differences Between Elderly Men and Women.
    Am J Hypertens 2018 Jun;31(7):797-803
    Laboratory of Neurosciences, School of Medicine and Institute for Biological Research, University of Zulia, Zulia, Venezuela.
    Background: Orthostatic hypotension (OH) occurs when mechanisms regulating blood pressure (BP) levels after standing-up are altered. It is unclear how prevalence and risk factors for OH are different between sexes. We aimed to investigate sex differences in prevalence and risk factors for OH elderly individuals. Read More

    Factors Associated with Hypertension Control in U.S. Adults Using 2017 ACC/AHA Guidelines: National Health and Nutrition Examination Survey 1999-2016.
    Am J Hypertens 2018 Mar 29. Epub 2018 Mar 29.
    Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland.
    Background: Factors and trends associated with hypertension control (BP <130/<80 mm Hg) and mean blood pressure (BP) among hypertensive adults (BP ≥130/80 mm Hg or medicated for hypertension).

    Method: Data on 22,911 hypertensive US adults from the 1999-2016 National Health and Nutrition Examination Survey.

    Results: For men, hypertension control prevalence increased from 8. Read More

    Serum Cortisol and Cortisone as potential biomarkers of Partial 11β-hydroxysteroid dehydrogenase type-2 Deficiency.
    Am J Hypertens 2018 Mar 30. Epub 2018 Mar 30.
    Department of Endocrinology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago Centro, Santiago, Chile.
    Background: Pathogenic variations in HSD11B2 gene triggers the apparent mineralocorticoid excess syndrome (AME). There is scarce information regarding the phenotypes of subjects carrying heterozygous pathogenic variants in HSD11B2 gene. We investigated if serum cortisol/cortisone(F/E) ratio and cortisone are useful for identifying partial 11βHSD2 deficiency in those heterozygous subjects. Read More

    Polymorphisms Within RYR3 Gene Are Associated With Risk and Age at Onset of Hypertension, Diabetes, and Alzheimer's Disease.
    Am J Hypertens 2018 Jun;31(7):818-826
    Department of Health and Biomedical Sciences, College of Health Affairs, University of Texas Rio Grande Valley, Brownsville, Texas, USA.
    Background: Hypertension affects 33% of Americans while type 2 diabetes and Alzheimer's disease (AD) affect 10% of Americans, respectively. Ryanodine receptor 3 gene (RYR3) codes for the RYR which functions to release stored endoplasmic reticulum calcium ions (Ca2+) to increase intracellular Ca2+ concentration. Increasing studies demonstrate that altered levels of intracellular Ca2+ affect cardiac contraction, insulin secretion, and neurodegeneration. Read More

    Target Organ Damage and Target Systolic Blood Pressure in Clinical Practice: The Campania Salute Network.
    Am J Hypertens 2018 May;31(6):658-664
    Hypertension Research Center, Federico II University, Naples, Italy.
    Background: Lowering systolic blood pressure (SBP) below the conventional threshold (140 mm Hg) reduces left ventricular (LV) hypertrophy and incident cardiovascular (CV) events. We assessed whether different thresholds of SBP as the average value during follow-up (FU) have different impact on changes in target organ damage (TOD).

    Methods: From the Campania Salute Network registry, we selected 4,148 hypertensive patients with average SBP-FU <140 mm Hg, and without history of prevalent CV or chronic kidney disease (i. Read More

    Polypill Variants (Quarter Pill Trials).
    Am J Hypertens 2018 Jun;31(7):758-761
    PHRI Hamilton Health Sciences- McMaster University, Hamilton, Ontario, Canada.
    The cardiovascular polypill or fixed-dose combination pill, consisting of 3, 4, or more drugs in a single tablet (or capsule), has been proposed as an effective and convenient therapy in both secondary and primary prevention of cardiovascular disease (CVD). Each of the drugs in the combination has a documented ability to prevent CVD events. The combined effect has been estimated to reduce risk by 75% to 80%. Read More

    Diabetes and Hypertension: Clinical Update.
    Am J Hypertens 2018 Apr;31(5):515-521
    School of Medicine, Diabetes and Cardiovascular Center, University of Missouri-Columbia, Columbia, Missouri, USA.
    The presence of hypertension in individuals with type 2 diabetes augments the risk for cardiovascular morbidity and mortality. In this regard, data support that management of hypertension in this high-risk population is a critical risk reduction strategy. In recent years, a number of work groups have redefined hypertension, management strategies, and targets. Read More

    The influence of sodium and potassium intake and insulin resistance on blood pressure in normotensive individuals is more evident in women.
    Am J Hypertens 2018 Mar 14. Epub 2018 Mar 14.
    Department of Internal Medicine, Takamatsu Hospital, Kagawa, Japan.
    Background: Considering sex differences, salt sensitivity and insulin resistance (IR), the effect of sodium restriction and increased potassium intake on blood pressure remains unclear in normotensive Asian individuals, compared to that in hypertensive patients.

    Methods: To assess the influence of sodium and potassium intake in normotensive individuals, we evaluated the estimated 24-hour urinary sodium and potassium excretion rate in 3,392 drug-naïve normotensive Japanese individuals (average age: 48.4 years) and analyzed its relation to blood pressure using multivariate regression analysis (MRA). Read More

    Progress in the Management of Primary Aldosteronism.
    Am J Hypertens 2018 Apr;31(5):522-531
    Division of Nephrology, Endocrinology and Vascular Medicine, Department of Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan.
    Primary aldosteronism (PA) is now considered as one of leading causes of secondary hypertension, accounting for 5-10% of all hypertensive patients and more strikingly 20% of those with resistant hypertension. Importantly, those with the unilateral disease could be surgically cured when diagnosed appropriately. On the other hand, only a very limited portion of those suspected to have PA has been screened, diagnosed, or treated to date. Read More

    Handgrip Strength and Blood Pressure in Children and Adolescents: Evidence From NHANES 2011 to 2014.
    Am J Hypertens 2018 Jun;31(7):792-796
    Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
    Background: Previous studies have reported that handgrip strength, a measure of muscular fitness, is associated with cardiovascular risk factors. However, the association of handgrip strength with blood pressure (BP) in children has been inconsistent. We tested the association of handgrip strength with systolic and diastolic BP in children and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Read More

    West African Ancestry and Nocturnal Blood Pressure in African Americans: The Jackson Heart Study.
    Am J Hypertens 2018 05;31(6):706-714
    Division of Health System Innovation and Research, Department of Population Health Sciences, University of Utah, Salt Lake City, Utah, USA.
    Background: African Americans have a higher prevalence of nocturnal hypertension and nondipping blood pressure than European Americans, but the genetic contribution to these racial differences remains unclear. We assessed the association of the percentage West African genetic ancestry with nocturnal hypertension and nondipping blood pressure in 932 African Americans from the Jackson Heart Study.

    Methods: Using percentage West African ancestry determined from 389 ancestry informative markers, participants were categorized into tertiles (tertile 1 [low]: <79. Read More

    Cure With Cryoablation of Arterial Hypertension Due to a Renin-Producing Tumor.
    Am J Hypertens 2018 Apr;31(5):537-540
    Clinica dell'Ipertensione Arteriosa, Department of Medicine - DIMED, University of Padua, Italy.
    Background: We herein report on a 20 years old woman with stage I hypertension, who was found to carry a renin-producing tumor (RPT).

    Methods: Due to her young age, the patient underwent screening measurement of plasma renin and aldosterone, abdominal computed tomography (CT) angiography, and selective renal vein renin assessment to identify secondary hypertension.

    Results: The patient was screened for secondary causes of hypertension and was diagnosed with secondary aldosteronism. Read More

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