7,462 results match your criteria American journal of hypertension[Journal]


Using predicted atherosclerotic cardiovascular disease risk for discrimination of awake or nocturnal hypertension.

Am J Hypertens 2020 Jul 13. Epub 2020 Jul 13.

University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: Several atherosclerotic cardiovascular disease (ASCVD) risk factors are associated with awake and nocturnal hypertension.

Methods: We assessed the association between a composite ASCVD risk score and awake or nocturnal hypertension using data from participants aged 40-79 years who completed ambulatory blood pressure monitoring at the Year 30 Coronary Artery Risk Development in Young Adults study exam in 2015-2016 (n=716) and the baseline Jackson Heart Study exam in 2000-2004 (n=770). Ten-year predicted ASCVD risk was calculated using the Pooled Cohort risk equations. Read More

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http://dx.doi.org/10.1093/ajh/hpaa099DOI Listing

Age-specific acute changes in carotid-femoral pulse wave velocity with head-up tilt.

Am J Hypertens 2020 Jul 7. Epub 2020 Jul 7.

Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Background: Aortic stiffness as measured by carotid-femoral pulse wave velocity (cfPWV) is known to depend on blood pressure (BP), and this dependency may change with age. Therefore, the hydrostatic BP gradient resulting from a change in body posture may elicit a cfPWV change that is age-dependent. We aimed to analyze the relationship between BP gradient - induced by head-up body tilting - and related changes in cfPWV in individuals of varying age. Read More

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http://dx.doi.org/10.1093/ajh/hpaa101DOI Listing

The Road to Implementing Home Blood Pressure Monitoring: Are We There Yet?

Am J Hypertens 2020 Jul 7. Epub 2020 Jul 7.

The Columbia Hypertension Center, Columbia University Irving Medical Center, New York, NY.

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http://dx.doi.org/10.1093/ajh/hpaa109DOI Listing

The renal dangers of an increased Cardio-Ankle Vascular Index.

Am J Hypertens 2020 Jul 7. Epub 2020 Jul 7.

Dipartimento PROMISE (Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties), Unit of Nephrology and Hypertension, European Society of Hypertension Excellence Centre, Università di Palermo, Italy.

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http://dx.doi.org/10.1093/ajh/hpaa110DOI Listing

EFFECT OF LOWER BLOOD PRESSURE GOALS ON LEFT VENTRICULAR STRUCTURE AND FUNCTION IN PATIENTS WITH SUBCLINICAL HYPERTENSIVE HEART DISEASE.

Am J Hypertens 2020 Jul 5. Epub 2020 Jul 5.

Department of Internal Medicine, Southern Illinois University, Springfield, Il.

Background: Subclinical hypertensive heart disease (SHHD) is a precursor to heart failure. Blood pressure (BP) reduction is an important component of secondary disease prevention in patients with SHHD. Treating patients with SHHD utilizing a more intensive BP target (120/80 mm Hg), may lead to improved cardiac function but there has been limited study of this, particularly in African Americans (AAs). Read More

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http://dx.doi.org/10.1093/ajh/hpaa108DOI Listing

Dietary Sodium Intake and Sodium Density in the United States - Estimates from NHANES 2005-2006 and 2015-2016.

Am J Hypertens 2020 Jul 3. Epub 2020 Jul 3.

Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA.

Background: In the United States, current guidelines recommend a total sodium intake <2300mg/day, a guideline which does not consider kilocalorie intake. However, kilocalorie intake varies substantially by age and sex. We hypothesized that compared to sodium density, total sodium intake overestimates adherence to sodium recommendations, especially in adults consuming fewer kilocalories. Read More

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http://dx.doi.org/10.1093/ajh/hpaa104DOI Listing

Artificial Intelligence and Hypertension: Recent Advances and Future Outlook.

Am J Hypertens 2020 Jul 2. Epub 2020 Jul 2.

Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.

Prevention and treatment of hypertension (HTN) is a challenging public health problem. Recent evidence suggests that artificial intelligence (AI) has potential to be a promising tool for reducing the global burden of HTN, and furthering precision medicine related to cardiovascular (CV) diseases including HTN. Since AI can stimulate human thought processes and learning with complex algorithms and advanced computational power, AI can be applied to multimodal and big data, including genetics, epigenetics, proteomics, metabolomics, CV imaging, socioeconomic, behavioral and environmental factors. Read More

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http://dx.doi.org/10.1093/ajh/hpaa102DOI Listing

Microbiota and hypertension: role of the sympathetic nervous system and the immune system.

Am J Hypertens 2020 Jul 2. Epub 2020 Jul 2.

Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain.

There are numerous studies indicating a direct association between hypertension and gut microbiota in both animal models and humans. In this review we focused on the imbalance in the gut microbiota composition relative to healthy state or homeostasis, termed dysbiosis, associated with hypertension and discuss the current knowledge regarding how microbiota regulates blood pressure, involving the sympathetic nervous system and the immune system. The profile of ecological parameters and bacterial genera composition of gut dysbiosis in hypertension varies according to the experimental model of hypertension. Read More

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http://dx.doi.org/10.1093/ajh/hpaa103DOI Listing

Factors associated with physician recommendation of home blood pressure monitoring and blood pressure in the US population.

Am J Hypertens 2020 Jun 15. Epub 2020 Jun 15.

The Johns Hopkins School of Medicine, Baltimore, MD.

Background: Hypertension guidelines recommend home blood pressure monitoring (HBPM) to help achieve blood pressure (BP) control. We hypothesized that HBPM use with a physician recommendation would be associated with lower blood pressure and greater medication adherence.

Methods: We used data from 6,320 adults with hypertension in the National Health and Nutrition Examination Survey 2009-2014 to characterize the association of 1) provider recommendation for HBPM and 2) HBPM use on two outcomes: measured BP (linear regression) and medication adherence (logistic regression). Read More

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http://dx.doi.org/10.1093/ajh/hpaa093DOI Listing

Mitophagy in Hypertension-Associated Premature Vascular Aging.

Am J Hypertens 2020 Apr 6. Epub 2020 Apr 6.

Center for Hypertension & Personalized Medicine, Department of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA.

Hypertension has been described as a condition of premature vascular aging, relative to actual chronological age. In fact, many factors that contribute to the deterioration of vascular function as we age are accelerated and exacerbated in hypertension. Nonetheless, the precise mechanisms that underlie the aged phenotype of arteries from hypertensive patients and animals remain elusive. Read More

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http://dx.doi.org/10.1093/ajh/hpaa058DOI Listing

Associations between day-by-day home blood pressure variability and renal function and albuminuria in patients with and without diabetes.

Am J Hypertens 2020 Jun 12. Epub 2020 Jun 12.

Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Yakushiji, Shimotsuke-shi, Tochigi, Japan.

Background: The phenotype of diabetic kidney disease represents a lower estimated glomerular filtration rate (eGFR) and albuminuria. We investigated the association between day-by-day home blood pressure (BP) variability and the eGFR in subjects with diabetes and compared this association with that in subjects without diabetes. We then attempted to determine whether the association is present in albuminuria. Read More

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http://dx.doi.org/10.1093/ajh/hpaa091DOI Listing

Association of arterial stiffness with kidney function among adults without chronic kidney disease.

Am J Hypertens 2020 Jun 12. Epub 2020 Jun 12.

Department of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, Okayama, Japan.

Background: Our aims were to assess whether arterial stiffness is associated with a higher risk for kidney dysfunction among persons without chronic kidney disease (CKD).

Methods: We analyzed data from the national health check-up system in Japan; for our analyses, we selected records of individuals who completed assessments of cardio-ankle vascular index (CAVI) and kidney function from 2005 to 2016. We excluded participants who had CKD at baseline, defined as the presence of proteinuria or estimated glomerular filtration rate (eGFR) <60 mL/min/1. Read More

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http://dx.doi.org/10.1093/ajh/hpaa097DOI Listing

Antihypertensive Drugs and Risk of Cancer. Between Scylla and Charybdis.

Am J Hypertens 2020 Jun 12. Epub 2020 Jun 12.

Hypertension Excellence Centre - ESH, Dept. of Cardiology, LAIKO General Hospital, Athens, Greece.

Antihypertensive drugs namely angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs), beta blockers and diuretics are among the most clearly documented regimens worldwide with an overall cardioprotective benefit. Given that malignancy is the second leading cause of mortality, numerous observational studies aimed to investigate the carcinogenic potential of these agents with conflicting results. The purpose of this review was to summarize current data in an effort to explore rare side effects and new mechanisms linking antihypertensive drugs with the risk of developing cancer. Read More

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http://dx.doi.org/10.1093/ajh/hpaa098DOI Listing
June 2020
2.852 Impact Factor

Potential impact of the 2017 high blood pressure guideline beyond the United States: A case study of the People's Republic of China.

Am J Hypertens 2020 Jun 10. Epub 2020 Jun 10.

The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University. Hangzhou, Zhejiang, China.

Background: The 2017 ACC/AHA (US) Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults expanded the definition of hypertension and now considers atherosclerotic cardiovascular disease (ASCVD) risk in determining treatment for people with hypertension. US guidelines are influential around the world and it is therefore justified to study their impact in other settings. Our study determined the impact of adopting the 2017 ACC/AHA guideline in China. Read More

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http://dx.doi.org/10.1093/ajh/hpaa094DOI Listing

The Peripheral Nervous System and Changes in Blood Pressure: Lights and Darkness.

Am J Hypertens 2020 Jun 10. Epub 2020 Jun 10.

Clinical Epidemiology and Vascular Risk Unit. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, España.

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http://dx.doi.org/10.1093/ajh/hpaa095DOI Listing

Cuff-less, personal, ambulatory blood pressure devices and disruption of existing blood pressure measurement paradigms.

Am J Hypertens 2020 Jun 9. Epub 2020 Jun 9.

Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.

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http://dx.doi.org/10.1093/ajh/hpaa090DOI Listing

Use of RAAS inhibitors and risk of clinical deterioration in COVID-19: results from an Italian cohort of 133 hypertensives.

Am J Hypertens 2020 Jun 8. Epub 2020 Jun 8.

Department of Medicine - DIMED, Medicina Generale I^, Ca' Foncello Hospital, Treviso, University of Padova, Padua, Italy.

Background: The effect of chronic use of renin-angiotensin-aldosterone system (RAAS) inhibitors on the severity of COVID-19 infection is still unclear in patients with hypertension. We aimed to investigate the association between chronic use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) and COVID-19 related outcomes in hypertensive patients.

Methods: A single center study was conducted on 133 consecutive hypertensive subjects presenting to the Emergency Department with acute respiratory symptoms and/or fever who were diagnosed with COVID-19 infection between 9th and 31st March 2020. Read More

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http://dx.doi.org/10.1093/ajh/hpaa096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314218PMC

Advances and challenges in the electrocardiographic diagnosis of left ventricular hypertrophy in hypertensive individuals.

Am J Hypertens 2020 Jun 7. Epub 2020 Jun 7.

Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

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http://dx.doi.org/10.1093/ajh/hpaa092DOI Listing

TNFα and Reactive Oxygen Signaling in Vascular Smooth Muscle Cells in Hypertension and Atherosclerosis.

Am J Hypertens 2020 Jun 5. Epub 2020 Jun 5.

Division of Pediatric Critical Care, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.

Hypertension and atherosclerosis, the predecessors of stroke and myocardial infarction, are chronic vascular inflammatory reactions. Tumor necrosis factor alpha (TNFα), the "master" pro-inflammatory cytokine, contributes to both the initiation and maintenance of vascular inflammation. TNFα induces reactive oxygen species (ROS) production which drives the redox reactions that constitute "ROS signaling". Read More

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http://dx.doi.org/10.1093/ajh/hpaa089DOI Listing

Association of Obstructive Sleep Apnea with Nighttime Blood Pressure in African Americans: the Jackson Heart Study.

Am J Hypertens 2020 Jun 3. Epub 2020 Jun 3.

Brigham and Women's Hospital, Boston, MA.

Background: Obstructive sleep apnea (OSA), nocturnal hypertension, and non-dipping systolic blood pressure (BP) are each highly prevalent among African Americans. However, few data are available on the association between OSA and nighttime BP in this population.

Methods: We examined the association of OSA with nighttime BP among African Americans who completed 24-hour ambulatory BP monitoring at Exam 1 (2000-2004) of the Jackson Heart Study (JHS) and subsequently participated in the JHS Sleep Study (2012-2016). Read More

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http://dx.doi.org/10.1093/ajh/hpaa088DOI Listing

Hyperhomocysteinemia-induced oxidative stress aggravates renal damage in hypertensive rats.

Am J Hypertens 2020 Jun 2. Epub 2020 Jun 2.

Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China.

Background: Hyperhomocysteinemia (HHcy) plays a synergistic role with hypertension in vascular injury; however, the relationship between HHcy and hypertension in renal injury remains unclear. Here, we sought to evaluate the relationship between HHcy and hypertension in the context of renal injury and to elucidate the mechanism of action underlying this relationship.

Methods: Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats were randomized into WKY, WKY+HHcy, SHR, and SHR+HHcy groups. Read More

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http://dx.doi.org/10.1093/ajh/hpaa086DOI Listing
June 2020
2.852 Impact Factor

Performance of Electrocardiographic Criteria for Echocardiographically Diagnosed Left Ventricular Hypertrophy in Chinese Hypertensive Patients.

Am J Hypertens 2020 Jun 2. Epub 2020 Jun 2.

The Shanghai Institute of Hypertension, Department of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: Performance of electrocardiographic (ECG) criteria for echocardiographically diagnosed left ventricular hypertrophy (LVH) in Chinese hypertensive patients is not well known. We investigated the accuracy of various ECG criteria for the diagnosis of the echocardiographic LVH according to the new cutoff values of left ventricular mass (LVM) index (>115 g/m2 for men and >95 g/m2 for women) in Chinese hypertensive patients.

Methods: Our study included 702 consecutive hypertensive inpatients including 92 (13. Read More

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http://dx.doi.org/10.1093/ajh/hpaa083DOI Listing
June 2020
2.852 Impact Factor

MiR-17 knockdown promotes vascular smooth muscle cell phenotypic modulation through upregulated interferon regulator factor 9 expression.

Am J Hypertens 2020 Jun 2. Epub 2020 Jun 2.

The First Hospital of Nanchang, Nanchang, China.

Background: MiR-17 is a small noncoding RNA that plays an important role in the development of tumorgenesis, which recently has emerged to be involved in regulation of inflammatory responses and angiogenesis. However, the effect and underlying mechanism of miR-17 on vascular smooth muscle cell (VSMC) phenotypic modulation have not been investigated.

Methods And Results: In the current study, we observed that miR-17 expression tested by RT-PCR was downregulated in VSMCs administrated with platelet-derived growth factor-BB (PDGF-BB) stimulation and carotid arteries subjected to wire injury, which were accompanied with decreased VSMC differentiation markers. Read More

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http://dx.doi.org/10.1093/ajh/hpaa087DOI Listing

Chemerin as a driver of hypertension: a consideration.

Am J Hypertens 2020 May 26. Epub 2020 May 26.

Department of Pharmacology and Toxicology, Michigan State University, East Lansing MI, USA.

The protein chemerin (tazarotene induced gene, TIG2; RARRES2) is a relatively new adipokine. Many studies support that circulating chemerin levels associate strongly and positively with BMI, visceral fat and blood pressure. Here, we focus on the specific relationship of chemerin and blood pressure with the goal of understanding whether and how chemerin drives (pathological) changes in blood pressure such that it could be interfered with therapeutically. Read More

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http://dx.doi.org/10.1093/ajh/hpaa084DOI Listing

Cost-Related Antihypertensive Medication Nonadherence:Action in the Time of COVID-19 and Beyond.

Am J Hypertens 2020 May 25. Epub 2020 May 25.

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL.

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http://dx.doi.org/10.1093/ajh/hpaa085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314165PMC

Response to: Socioeconomic Status and Hypertension in African Americans from the Jackson Heart Study.

Am J Hypertens 2020 May 21. Epub 2020 May 21.

National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/ajh/hpaa082DOI Listing

Unraveling the prevalence of Angiotensin II type 1 receptor antibodies in hypertension.

Am J Hypertens 2020 May 20. Epub 2020 May 20.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Nephrology and Medical Intensive Care, CVK, Berlin, Germany.

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http://dx.doi.org/10.1093/ajh/hpaa079DOI Listing

Prognostic Value of Masked Uncontrolled Hypertension Defined by Different Ambulatory Blood Pressure Criteria.

Am J Hypertens 2020 May 18. Epub 2020 May 18.

Department of Medical, Oral and Biotechnological Sciences, University "Gabriele d'Annunzio", Chieti-Pescara, Chieti, Italy.

Background: Masked uncontrolled hypertension (MUCH), that is, non-hypertensive clinic but high out-of-office blood pressure (BP) in treated patients is at increased cardiovascular risk than controlled hypertension (CH), that is, non-hypertensive clinic and out-of-office BP. Using ambulatory BP, MUCH can be defined as daytime and/or nighttime and/or 24-hour BP above thresholds. It is unclear whether different definitions of MUCH have similar prognostic information. Read More

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http://dx.doi.org/10.1093/ajh/hpaa078DOI Listing

Aortic Hemodynamics and Cognitive Performance in Postmenopausal Women: Impact of Pregnancy History.

Am J Hypertens 2020 May 18. Epub 2020 May 18.

Department of Kinesiology, University of Wisconsin-Madison, Madison, WI.

Background: Studies demonstrate an association between aortic hemodynamics and cognitive function. The impact of pregnancy history on this association is unknown.

Methods: Postmenopausal women (age 59±5 y; years since last pregnancy 35±3) with either a history of preeclampsia (PE; n=34) or with a history of a normotensive pregnancy (NP; n=30) underwent cognitive testing: Letter-Number Sequencing, Digit Span, Trail Making Test, and letter and category fluency. Read More

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http://dx.doi.org/10.1093/ajh/hpaa081DOI Listing

Response to COVID-19 and ACEI/ARB: NOT ASSOCIATED?

Am J Hypertens 2020 May 16. Epub 2020 May 16.

Department of Cell Biology and Anatomy, and Cardiovascular Translational Research Centre, University of South Carolina, Columbia, SC.

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http://dx.doi.org/10.1093/ajh/hpaa077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239260PMC

COVID-19 and ACEI/ARB: NOT ASSOCIATED?

Am J Hypertens 2020 May 16. Epub 2020 May 16.

Icahn School of Medicine at Mount Sinai/Mount Sinai St Luke's Roosevelt Hospital, Manhattan, New York.

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http://dx.doi.org/10.1093/ajh/hpaa076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239222PMC
May 2020
2.852 Impact Factor

Relationship of socioeconomic status to arterial stiffness: comparison between medical aid beneficiaries and National Health Insurance beneficiaries.

Am J Hypertens 2020 May 11. Epub 2020 May 11.

Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: There is no general agreement on underlying pathophysiology explaining the high burden of cardiovascular disease on people at low socioeconomic status. This study was conducted to investigate the association between healthcare systems and arterial stiffness.

Methods: A total of 8929 subjects (60 years old and 55% were male) who underwent brachial-ankle pulse wave velocity (baPWV) measurement were retrospectively analyzed. Read More

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http://dx.doi.org/10.1093/ajh/hpaa075DOI Listing

Sympathetic Activation in Hypertension: Importance of the Central Nervous System.

Am J Hypertens 2020 May 6. Epub 2020 May 6.

Department of Medical Technology and Sciences, International University of Health and Welfare.

The sympathetic nervous system plays a critical role in the pathogenesis of hypertension. The central nervous system (CNS) organizes the sympathetic outflow and various inputs from the periphery. The brain renin-angiotensin system has been studied in various regions involved in controlling sympathetic outflow. Read More

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http://dx.doi.org/10.1093/ajh/hpaa074DOI Listing

Empagliflozin for Patients with Presumed Resistant Hypertension: a Post Hoc Analysis of the EMPA-REG OUTCOME Trial.

Am J Hypertens 2020 May 5. Epub 2020 May 5.

Université de Lorraine, Centre d'Investigations Cliniques Plurithématique Inserm 1433, Nancy, France, CHRU de Nancy, Inserm U1116, Nancy, France, FCRIN INI-CRCT, Nancy, France.

Background: Type 2 diabetes (T2D) and resistant hypertension (rHT) often coexist, greatly increasing risk of target-organ damage and death. We explored the effects of empagliflozin in patients with and without presumed resistant hypertension (prHT) in a post hoc analysis of EMPA-REG OUTCOME (NCT01131676).

Methods: Overall, 7020 patients received empagliflozin 10mg, 25mg, or placebo with median follow-up of 3. Read More

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http://dx.doi.org/10.1093/ajh/hpaa073DOI Listing

Association between cost-related medication nonadherence and hypertension management among US adults.

Am J Hypertens 2020 May 5. Epub 2020 May 5.

Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, New Haven, CT.

Background: Medication nonadherence is an important element of uncontrolled hypertension. Financial factors are frequently contributor to nonadherence. The objective of this study was to examine the association between cost-related medication nonadherence and self-reported antihypertensive medication use and self-reported normal blood pressure among US adults with self-reported hypertension. Read More

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http://dx.doi.org/10.1093/ajh/hpaa072DOI Listing

White Coat Hypertension-A Case for Assessing Vascular Age?

Am J Hypertens 2020 Apr 29. Epub 2020 Apr 29.

Iverson Health Innovation Research Institute, Swinburne University of Technology, Hawthorn, Australia.

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http://dx.doi.org/10.1093/ajh/hpaa061DOI Listing

American Versus European Hypertension Guidelines: The Case of White Coat Hypertension.

Am J Hypertens 2020 Apr 29. Epub 2020 Apr 29.

Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.

Background: The impact of the 2017 American College Cardiology/American Heart Association guidelines on reclassification of white coat hypertension (WCH) and white coat uncontrolled hypertension (WUCH) phenotypes has not been thoroughly investigated, so far. The aim of the present analysis was to compare the prevalence rates of WCH and WUCH according to either 2018 European Society Hypertension/European Society Cardiology and 2017 ACC/AHA hypertension guidelines.

Methods: A large database of individual 24-hour ambulatory blood pressure (BP) recordings from untreated and treated hypertensive individuals with office BP ≥140 and/or 90 mm Hg was analyzed. Read More

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http://dx.doi.org/10.1093/ajh/hpaa029DOI Listing

Use of a Combination of Insulin Sensitizers and Antioxidant Supplements in the Management of Pregnancy Hypertensive Disorders.

Am J Hypertens 2020 Apr 27. Epub 2020 Apr 27.

Cardiovascular Translational Research Center, School of Medicine Columbia, University of South Carolina.

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http://dx.doi.org/10.1093/ajh/hpaa063DOI Listing

Prevalence of Angiotensin II Type 1 Receptor Antibodies in Persons with Hypertension and Relation to Blood Pressure and Medication.

Am J Hypertens 2020 Apr 24. Epub 2020 Apr 24.

Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD.

Background: We aimed to determine the prevalence of antibodies against angiotensin II type 1 receptor (AT1RAbs) in hypertensive adults and elucidate the relation of anti-hypertensive medication type to blood pressure (BP) among persons with and without AT1RAb.

Methods: Sera from participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study with hypertension were tested for AT1RAb using a commercial ELISA [(OneLambda; positive ≥ 17 units/ml)]. BP measurements, uncontrolled BP (systolic BP ≥140 and/or diastolic BP ≥ 90 mmHg) and effect of BP medication type were compared for AT1RAb positive (+) versus negative (-) participants using descriptive statistics and multivariable regression. Read More

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http://dx.doi.org/10.1093/ajh/hpaa071DOI Listing

Associations of maternal early-pregnancy glucose concentrations with placental hemodynamics, blood pressure and gestational hypertensive disorders.

Am J Hypertens 2020 Apr 23. Epub 2020 Apr 23.

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Gestational diabetes mellitus is associated with increased risks of gestational hypertension and preeclampsia. We hypothesized that high maternal glucose concentrations in early pregnancy are associated with adverse placental adaptations and subsequently altered utero-placental hemodynamics during pregnancy, predisposing to an increased risk of gestational hypertensive disorders.

Methods: In a population-based prospective cohort study from early pregnancy onwards, among 6,078 pregnant women, maternal early-pregnancy non-fasting glucose concentrations were measured. Read More

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http://dx.doi.org/10.1093/ajh/hpaa070DOI Listing

Hypertension Management in Emergency Departments.

Am J Hypertens 2020 Apr 20. Epub 2020 Apr 20.

Wayne State University, Detroit, MI, USA.

Elevated blood pressure is pervasive among patients that visit emergency departments for their care. In this review article, we outline the current approach to the management of these individuals and highlight the crucial role emergency medicine clinicians play in reducing the morbidity associated with elevated blood pressure. We highlight the critical importance of immediate treatment when elevated blood pressure contributes to new or worsening end-organ injury but emphasize that such hypertensive emergencies are rare. Read More

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http://dx.doi.org/10.1093/ajh/hpaa068DOI Listing

How to Manage Hypertension in People with Diabetes.

Am J Hypertens 2020 Apr 20. Epub 2020 Apr 20.

From the Department of Medicine, Am. Heart Assoc. Comprehensive Hypertension Center, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago Medicine,Chicago, Il.

Hypertension is a common condition that is often seen in patients with diabetes. Both diseases increase the risk of morbidity and mortality from CV events and kidney disease progression. Factors that influence blood pressure control in diabetes include the persons' genetic background for hypertension and kidney disease, level of obesity and insulin resistance, the magnitude of pre-existing kidney disease, and lifestyle factors such as level of sodium and potassium intake, sleep quality and exercise effort all of which can affect levels of sympathetic nerve activity and contribute to increased blood pressure variability. Read More

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http://dx.doi.org/10.1093/ajh/hpaa067DOI Listing

Reserpine: A new consideration of an old drug for Hypertension?

Authors:
Matthew R Weir

Am J Hypertens 2020 Apr 18. Epub 2020 Apr 18.

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http://dx.doi.org/10.1093/ajh/hpaa069DOI Listing

Icotinib attenuates monocrotaline-induced pulmonary hypertension by preventing pulmonary arterial smooth muscle cell dysfunction.

Am J Hypertens 2020 Apr 17. Epub 2020 Apr 17.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, P.R. China.

Background: Aberrant activation of epidermal growth factor receptor (EGFR) signaling pathway is associated with the pathogenesis of pulmonary hypertension (PH). However, the effect of icotinib, a first-generation of EGFR tyrosine kinase inhibitor (EGFR-TKI), on PH remains to be elucidated.

Methods: PH rat model was established by a single intraperitoneal injection of monocrotaline (MCT, 60 mg/kg). Read More

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http://dx.doi.org/10.1093/ajh/hpaa066DOI Listing

Role of S-Equol, Indoxyl Sulfate, and Trimethylamine N-Oxide on Vascular Function.

Am J Hypertens 2020 Mar 30. Epub 2020 Mar 30.

Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan.

Gut microbiota have been emerging as important contributors to the regulation of host homeostasis. Accordingly, several substances converted by gut microbiota can have beneficial or adverse effects on human health. Among them, S-equol, which is produced from the isoflavone daidzein in the human and animal gut by certain microbiota, exerts estrogenic and antioxidant activities. Read More

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http://dx.doi.org/10.1093/ajh/hpaa053DOI Listing

Seasonal Blood Pressure Variation: A Neglected Confounder in Clinical Hypertension Research and Practice.

Am J Hypertens 2020 Apr 16. Epub 2020 Apr 16.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1093/ajh/hpaa056DOI Listing
April 2020
2.852 Impact Factor

Targeting white coat hypertension : Is the day-time enough?

Am J Hypertens 2020 Apr 10. Epub 2020 Apr 10.

Department of Medicine and Surgery, University of Milano-Bicocca, Milano.

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http://dx.doi.org/10.1093/ajh/hpaa062DOI Listing

Understanding the Complex Interaction Between Uric Acid and Hypertension.

Am J Hypertens 2020 Apr 8. Epub 2020 Apr 8.

Department of Cardiovascular Medicine, Nephrology and Neurology Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.

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http://dx.doi.org/10.1093/ajh/hpaa050DOI Listing

Comparison of blood pressure variability between losartan and amlodipine in essential hypertension (COMPAS-BPV).

Am J Hypertens 2020 Apr 8. Epub 2020 Apr 8.

Division of Cardiology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Wonju, Republic of Korea.

Background: Antihypertensive therapy using renin-angiotensin system blockers and calcium channel blockers to target blood pressure variability (BPV) has not yet been established. We aimed to compare the ability of losartan and amlodipine to lower BPV and systolic BP (SBP) in essential hypertensive patients.

Methods: Patients were randomly assigned either losartan 50 mg or amlodipine 5 mg. Read More

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http://dx.doi.org/10.1093/ajh/hpaa060DOI Listing
April 2020
2.852 Impact Factor