342,224 results match your criteria American journal of critical care : an official publication American Association of Critical-Care Nurses[Journal]


Integrating Bleeding Control Training Into Surgical Missions in Low- and Middle-Income Countries.

J Surg Res 2019 Apr 17;241:53-56. Epub 2019 Apr 17.

Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey.

Background: Basic bleeding control (BCon) techniques can save lives globally but the knowledge is not widespread in low-income countries where trauma is a common cause of death. Short-term surgical missions (STSMs) are an effective route to share this public health initiative around the world.

Materials And Methods: Over 2017-2018, the International Surgical Health Initiative organized STSMs to locations in Sierra Leone, Bangladesh, Peru, and Ghana. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.020DOI Listing

Perioperative Morbidity of Gastrectomy During CRS-HIPEC: An ACS-NSQIP Analysis.

J Surg Res 2019 Apr 17;241:31-39. Epub 2019 Apr 17.

Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:

Background: Formal gastrectomy is occasionally required to achieve complete cytoreduction for patients with peritoneal surface malignancies. In addition, the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with gastric cancer is increasingly being explored. Nevertheless, data on the safety of gastrectomy at the time of CRS-HIPEC are limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193015
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http://dx.doi.org/10.1016/j.jss.2019.03.036DOI Listing
April 2019
1 Read

AAPT Diagnostic Criteria for Chronic Painful Temporomandibular Disorders.

J Pain 2019 Apr 17. Epub 2019 Apr 17.

Departments of Psychiatry and Behavioral Sciences, and Oral Medicine, Schools of Medicine and Dentistry, University of Washington (Emeritus).

The classification of temporomandibular disorders (TMD) has progressed substantially over the past 25 years due to the strategic implementation of an initial classification system based on core taxonomic principles. In this article we describe the development of the DC/TMD and its translation into the multidimensional ACTTION-American Pain Society Pain Taxonomy (AAPT) for chronic pain disorders. The initial scientific classification system (RDC/TMD) relied upon a boot-strapping process that did not attempt to solve all known clinical problems but, rather, focused on problems that could be solved at that time. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.04.003DOI Listing

30 Years (and More) of Hair Research Societies.

J Am Acad Dermatol 2019 Apr 17. Epub 2019 Apr 17.

The Society for Hair Science Research (Japan), Okubo 2-4-12, Shinjuku-ku, Shunkosha, Co. 169-0072 Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jaad.2019.04.028DOI Listing

Race-associated expression of MHC class I polypeptide-related sequence A (MICA) in prostate cancer.

Exp Mol Pathol 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA; Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USA; Center for Clinical and Translational Science (CCTS), University of Mississippi School of Pharmacy & University of Mississippi Medical Center, Jackson, MS, USA. Electronic address:

Despite the lack of a complete understanding of the disparities involved, prostate cancer (PCa) has both higher incidence and death rates in African American Men (AAM) relative to those of Caucasian American Men (CAM). MHC class I polypeptide related sequence A (MICA) is an innate immunity protein involved in tumor immunoevasion. Due to a lack of reports of race-specific expression of MICA in PCa, we evaluated MICA expression in patients' tumors and in cell lines from a racially diverse origin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144800193014
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http://dx.doi.org/10.1016/j.yexmp.2019.04.010DOI Listing
April 2019
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Molecular Characterization of sessile serrated adenoma/polyps from a large African American cohort.

Gastroenterology 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology, Howard University College of Medicine, Washington DC.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193670
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http://dx.doi.org/10.1053/j.gastro.2019.04.015DOI Listing
April 2019
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Young and middle-aged mouse breathing behavior during the light and dark cycles.

Physiol Rep 2019 Apr;7(8):e14060

Department of Biological Sciences, Le Moyne College, Syracuse, New York.

Unrestrained barometric plethysmography is a common method used for characterizing breathing patterns in small animals. One source of variation between unrestrained barometric plethysmography studies is the segment of baseline. Baseline may be analyzed as a predetermined time-point, or using tailored segments when each animal is visually calm. Read More

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http://dx.doi.org/10.14814/phy2.14060DOI Listing

Strong start for mothers and newborns: Moving birth centers to scale in the United States.

Birth 2019 Apr 19. Epub 2019 Apr 19.

Frontier Nursing University, Hyden, Kentucky.

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http://dx.doi.org/10.1111/birt.12430DOI Listing

Economic Evaluation of Sarilumab in the Treatment of Adult Patients with Moderately-to-Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Conventional Synthetic Disease-Modifying Antirheumatic Drugs.

Adv Ther 2019 Apr 19. Epub 2019 Apr 19.

University of Nebraska Medical Center, Omaha, NE, USA.

Introduction: Assess the cost-effectiveness (US healthcare payer perspective) of sarilumab subcutaneous (SC) 200 mg + methotrexate versus conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) or targeted DMARD + methotrexate for moderate-to-severe rheumatoid arthritis (RA) in adults with inadequate response to methotrexate.

Methods: Microsimulation based on patient profiles from MOBILITY (NCT01061736) was conducted via a 6-month decision tree and lifetime Markov model with 6-monthly cycles. Treatment response at 6 months was informed by a network meta-analysis and based on American College of Rheumatology (ACR) response. Read More

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http://dx.doi.org/10.1007/s12325-019-00946-1DOI Listing

LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease.

Mol Neurobiol 2019 Apr 19. Epub 2019 Apr 19.

Laboratory for Experimental Mouse Genetics, Department of Human Genetics, KU Leuven, Herestraat 49, Box 604, 3000, Leuven, Belgium.

The low-density lipoprotein receptor-related protein-1 (LRP1) has a dual role in the metabolism of the amyloid precursor protein (APP). In cellular models, LRP1 enhances amyloid-β (Aβ) generation via APP internalization and thus its amyloidogenic processing. However, conditional knock-out studies in mice define LRP1 as an important mediator for the clearance of extracellular Aβ from brain via cellular degradation or transcytosis across the blood-brain barrier (BBB). Read More

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http://dx.doi.org/10.1007/s12035-019-1594-2DOI Listing

Local-regional recurrence in women with small node-negative, HER2-positive breast cancer: results from a prospective multi-institutional study (the APT trial).

Breast Cancer Res Treat 2019 Apr 19. Epub 2019 Apr 19.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Purpose: Women with HER2-positive breast cancer treated prior to effective anti-HER2 therapy have higher rates of local-regional recurrence (LRR) than those with HER2-negative disease. Effective systemic therapy, however, has been shown to decrease LRR. This study examines LRR in women with HER2-positive breast cancer treated on a single-arm prospective multicenter trial of adjuvant trastuzumab (H) and paclitaxel (T). Read More

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http://dx.doi.org/10.1007/s10549-019-05238-4DOI Listing

Cardiovascular Risk in Type 1 Diabetes Mellitus.

Diabetes Ther 2019 Apr 19. Epub 2019 Apr 19.

Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9WU, UK.

Type 1 diabetes mellitus (T1DM) is associated with premature cardiovascular disease (CVD), but the underlying mechanisms remain poorly understood. The American Diabetes Association and the European Association for the Study of Diabetes recently updated their position statement on the management of type 2 diabetes mellitus (T2DM) to include additional focus on cardiovascular risk; improved management of risk factors in T1DM is also needed. There are important differences in the pathophysiology of CVD in T1DM and T2DM. Read More

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http://dx.doi.org/10.1007/s13300-019-0612-8DOI Listing

Possible Molecular Mediators Involved and Mechanistic Insight into Fibromyalgia and Associated Co-morbidities.

Neurochem Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.

Fibromyalgia is a chronic complex syndrome of non-articulate origin characterized by musculoskeletal pain, painful tender points, sleep problems and co-morbidities including depression, migraine. The etiopathogenesis of fibromyalgia is complex, variable and remains inconclusive. The etiological factors that have been defined include stress, genetic predisposition and environmental components. Read More

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http://link.springer.com/10.1007/s11064-019-02805-5
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http://dx.doi.org/10.1007/s11064-019-02805-5DOI Listing
April 2019
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Cardiovascular Risk Assessment Varies Widely by Calculator and Race/Ethnicity in a Majority Latinx Cohort Living with HIV.

J Immigr Minor Health 2019 Apr 19. Epub 2019 Apr 19.

Research to Advance Community Health (ReACH) Center, UT Health San Antonio, San Antonio, TX, USA.

Comparison of cardiovascular disease (CVD) risk calculators in Latinx majority populations living with HIV can assist clinicians in selecting a calculator and interpreting results. 10-year CVD risks were estimated for 652 patients seen ≥ 2 times over 12 months in a public clinic using three risk calculators: Atherosclerotic CVD risk Calculator (ASCVD), Framingham Risk Calculator (FRC), and Data Collection on Adverse Effects of Anti-HIV Drugs Study (D:A:D) Calculator. Median estimated 10-year CVD risk in this population was highest using FRC (11%), followed by D:A:D (10%), and lowest with ASCVD (5%; p < 0. Read More

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http://dx.doi.org/10.1007/s10903-019-00890-wDOI Listing

Association of body mass index with cardiac resynchronization therapy intention and left ventricular lead implantation failure: insights from the NCDR implantable cardioverter-defibrillator registry.

J Interv Card Electrophysiol 2019 Apr 19. Epub 2019 Apr 19.

Cardiac Electrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Diego, San Diego, CA, USA.

Background: Cardiac resynchronization therapy with defibrillator (CRT-D) implantation involves left ventricular (LV) lead placement for biventricular pacing and is more complex than implantable cardioverter-defibrillator (ICD)-only implantation. Differences in the prescription of CRT-D versus ICD may result from clinician biases based on patient body habitus, and body habitus may be associated with LV lead implantation failure.

Objective: We sought to evaluate whether patient body mass index (BMI) was associated with planned use and implantation failure of CRT-D therapy. Read More

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http://dx.doi.org/10.1007/s10840-019-00550-xDOI Listing

The Development of an Emergency Medicine Resident Research Program in the United States Military.

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

Department of Emergency Medicine, San Antonio Uniformed Services Health Education Consortium, 3551 Roger Brooke Dr, Fort Sam Houston, TX 78234, USA.

Introduction: The Accreditation Council for Graduate Medical Education stipulates that residents should participate in scholarly activity. As of 2019 that verbiage will be changed to, "Residents must participate in scholarship." However, scholarly activity is not clearly defined. Read More

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https://academic.oup.com/milmed/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/milmed/usz071DOI Listing
April 2019
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Onset of efficacy and duration of response of galcanezumab for the prevention of episodic migraine: a post-hoc analysis.

J Neurol Neurosurg Psychiatry 2019 Apr 19. Epub 2019 Apr 19.

Eli Lilly and Company, Indianapolis, Indiana, USA.

Background And Objective: As new migraine prevention treatments are developed, the onset of a preventive effect, how long it is maintained and whether patients initially non-responsive develop clinically meaningful responses with continued treatment can be assessed.

Methods: Analyses were conducted post-hoc of a double-blind, placebo-controlled, phase II-a study in patients with episodic migraine receiving galcanezumab 150 mg or placebo biweekly for 12 weeks ( 13:885, 2014). The number of migraine headache days per week, and onset of efficacy measured as the first week galacanezumab separated from placebo were determined. Read More

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http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2018-320242
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http://dx.doi.org/10.1136/jnnp-2018-320242DOI Listing
April 2019
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Honeybee-specific lactic acid bacterial supplements have no effect on American foulbrood infected honeybee colonies.

Appl Environ Microbiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, 750 07 Sweden.

, causative agent of American Foulbrood (AFB), is the primary bacterial pathogen affecting honeybees and beekeeping. The main methods for controlling AFB are incineration of diseased colonies or prophylactic antibiotic treatment (e.g. Read More

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http://aem.asm.org/lookup/doi/10.1128/AEM.00606-19
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http://dx.doi.org/10.1128/AEM.00606-19DOI Listing
April 2019
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Sex-related differences in patients undergoing surgery for shoulder instability: a Multicenter Orthopaedic Outcomes Network (MOON) Shoulder Instability cohort study.

J Shoulder Elbow Surg 2019 Apr 16. Epub 2019 Apr 16.

University of Kentucky Orthopaedic Surgery and Sports Medicine, Lexington, KY, USA.

Hypothesis And Background: Male sex has been identified as a risk factor for both primary shoulder dislocation and recurrent instability, and male patients more often undergo surgery for instability. Despite published discrepancies between sexes regarding the incidence and surgical rates of shoulder instability, there is little detail on the differences in presentation, mechanism of injury, and intraoperative findings. The purpose of this study was to explore these differences. Read More

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http://dx.doi.org/10.1016/j.jse.2019.02.020DOI Listing

Peer effects of obesity on child body composition.

Econ Hum Biol 2019 Apr 2. Epub 2019 Apr 2.

Yale School of Public Health, Yale University, 60 College St., New Haven, CT 06520, USA. Electronic address:

This study investigates whether peer obesity is a driver of individual weight changes in public school children and whether the impact of peer effects changes as children age. Quantifying peer effects is important for understanding the social determinants of obesity and for planning effective school wellness policies. However, the extant empirical research on peer effects is limited due to difficulties in separating causal influences from confounding factors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1570677X183022
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http://dx.doi.org/10.1016/j.ehb.2019.03.003DOI Listing
April 2019
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Uncovering differences in interoperability across hospital size.

Healthc (Amst) 2019 Apr 16. Epub 2019 Apr 16.

Office of the National Coordinator for Health Information Technology, U.S. Department of Health and Human Services, 330 C St SW, Floor 7, Washington, DC, 20201, USA.

Background: Small hospitals significantly lag behind large hospitals in interoperable health information exchange. This analysis identifies factors that explain differences in interoperability between these hospital types. We place a particular emphasis on such factors as number of functionalities within electronic health record system (EHR), participation in regional and national networks, and adoption of a dominant EHR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22130764183018
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http://dx.doi.org/10.1016/j.hjdsi.2019.04.001DOI Listing
April 2019
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Unequal Rates of Serious Perioperative Respiratory Adverse Events Between Black and White Children.

J Natl Med Assoc 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesiology, Section of Pediatric Anesthesiology, University of Michigan, Ann Arbor, MI, USA.

Background: Recent data among pediatric otolaryngology patients showed unexplained higher rates of serious perioperative respiratory adverse events (PRAE) in black children compared to their white peers. We evaluated whether preoperative respiratory comorbidity (PRC) burden contributes to racial disparity in serious PRAE in children undergoing non-otolaryngologic procedures.

Methods: Rates of serious PRAE (laryngospasm and/or bronchospasm) were compared across racial groups in a retrospective cohort of black and white children (N = 18538; black 10%) who underwent various elective, non-otolaryngologic procedures between 2007 and 2014 at a US tertiary Children's hospital. Read More

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http://dx.doi.org/10.1016/j.jnma.2019.03.006DOI Listing

Relationship Between Grip Strength and Prediabetes in a Large-Scale Adult Population.

Am J Prev Med 2019 Apr 17. Epub 2019 Apr 17.

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China; Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China. Electronic address:

Introduction: Prediabetes has been a growing health problem in China, and it is a high-risk state for developing diabetes and cardiovascular disease. In previous studies, low grip strength has been associated with diabetes. However, few population-based studies have examined the relationship between grip strength and prediabetes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07493797193005
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http://dx.doi.org/10.1016/j.amepre.2019.01.013DOI Listing
April 2019
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Total Hip Arthroplasty Through the Direct Anterior Approach Using a Bikini Incision Can Be Safely Performed in Obese Patients.

J Arthroplasty 2019 Apr 2. Epub 2019 Apr 2.

Rothman Orthopaedic Institute, Philadelphia, PA.

Background: Direct anterior approach (DAA) total hip arthroplasty can be performed through a traditional vertical incision or a horizontal (bikini) incision. The purpose of this study is to compare the 2 approaches, performed by a single surgeon past the learning curve, in terms of (1) overall wound complications and (2) patient-reported esthetics at the 6-month follow-up.

Methods: A case-control retrospective study was conducted. Read More

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http://dx.doi.org/10.1016/j.arth.2019.03.060DOI Listing

Including Lifestyle Medicine in Medical Education: Rationale for American College of Preventive Medicine/American Medical Association Resolution 959.

Am J Prev Med 2019 May;56(5):e169-e175

Department of Social Medicine and Health Science Leadership, Western University of Health Sciences College of Osteopathic Medicine of the Pacific-Northwest, Lebanon, Oregon.

Introduced by the American College of Preventive Medicine and released by the American Medical Association House of Delegates in 2017, Resolution 959 (I-17) supports policies and mechanisms that incentivize and/or provide funding for the inclusion of lifestyle medicine education and social determinants of health in undergraduate, graduate and continuing medical education. Resolution 959 was passed to help address the current healthcare costs of lifestyle-related, noncommunicable chronic diseases that exert a devastating economic burden on the U.S. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07493797183244
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http://dx.doi.org/10.1016/j.amepre.2018.10.034DOI Listing
May 2019
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Preconception Care in the Veterans Health Administration.

Semin Reprod Med 2018 Nov 19;36(6):327-339. Epub 2019 Apr 19.

VA Central Office, Women's Health Services, Washington, District of Columbia.

Preconception care (PCC), defined as a set of interventions to help women optimize their health and well-being prior to pregnancy, can improve pregnancy outcomes and is recommended by national organizations including the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists. Women Veterans who use the Department of Veterans Affairs (VA) health care system may face elevated risks of adverse pregnancy and birth outcomes due to a high prevalence of chronic medical and mental health conditions as well as psychosocial stressors including sexual trauma history and intimate partner violence. Many women Veterans of childbearing age experience poverty and homelessness, which are key social determinants of poor reproductive health outcomes. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678753
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http://dx.doi.org/10.1055/s-0039-1678753DOI Listing
November 2018
1 Read

Prevalence of adverse childhood experiences (ACEs) among US children.

Child Abuse Negl 2019 Apr 16;92:209-218. Epub 2019 Apr 16.

University of South Carolina College of Nursing, Columbia, South Carolina, United States.

Objective: The purpose of this study was to estimate the prevalence of adverse childhood experiences (ACEs) among children in the United States and to examine the relationship between child and family characteristics and the likelihood of reported exposure to ACEs.

Methods: Data were drawn from the nationally representative 2016 National Survey of Children's Health (NSCH). Parent-reported child ACE exposure was measured using counts of those reporting zero ACEs, one to three ACEs, and four or more ACEs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01452134193013
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http://dx.doi.org/10.1016/j.chiabu.2019.04.010DOI Listing
April 2019
3 Reads

Worldwide Network for Blood and Marrow Transplantation (WBMT) recommendations for establishing a hematopoietic stem cell transplantation program in countries with limited resources (Part II): clinical, technical and socio-economic considerations.

Biol Blood Marrow Transplant 2019 Apr 16. Epub 2019 Apr 16.

Center for Hematopoietic Stem Cell Transplantation, Aichi Medical University Hospital, Nagakute; Department of Hematology and Medical Oncology, University Hospital, Leipzig, Germany.

The development of hematopoietic stem cell transplantation (HSCT) programs can face significant challenges in most developing countries because such endeavors must compete with other government health care priorities, including the delivery of basic services. While this is may be a limiting factor, these countries should prioritize development of the needed expertise to offer state of the art treatments including transplantation, by providing financial, technological, legal, ethical and other needed support. This would prove beneficial in providing successful programs customized to the needs of their population, and potentially provide long-term cost-savings by circumventing the need for their citizens to seek care abroad. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.012DOI Listing

Larval amphibians rapidly bioaccumulate poly- and perfluoroalkyl substances.

Ecotoxicol Environ Saf 2019 Apr 16;178:137-145. Epub 2019 Apr 16.

Department of Forestry and Natural Resources, Purdue University, 715 West State Street, West Lafayette, IN, 47907, United States.

Poly- and perfluoroalkyl substances (PFAS) are ubiquitous contaminants that can bioaccumulate in aquatic taxa. Amphibians are particularly vulnerable to contaminants and sensitive to endocrine disruptors during their aquatic larval stage. However, few studies have explored PFAS uptake rates in amphibians, which is critical for designing ecotoxicology studies and assessing the potential for bioaccumulation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193043
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http://dx.doi.org/10.1016/j.ecoenv.2019.04.022DOI Listing
April 2019
2 Reads

Phylogenetic analysis of partial pre-membrane and envelope sequences of dengue viruses circulating in India.

Int J Infect Dis 2019 Apr 16. Epub 2019 Apr 16.

Dept. of Clinical Virology, Christian Medical College, Vellore 632004, Tamil Nadu, India. Electronic address:

Objective: Phylogenetic characteristics of circulating Indian dengue viruses (DENV) were analysed using partial pre-membrane (PrM) and envelope (E) sequences. An immunodominant region was analysed for mutations and alignment with common DENV PCR primers and probes was determined.

Methods: Published Indian PrM and E DENV sequences were analysed with hitherto unpublished PrM sequences from this study site. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.04.010DOI Listing

Trends in cervical cancer incidence rates by age, race/ethnicity, histological subtype, and stage at diagnosis in the United States.

Prev Med 2019 Apr 16. Epub 2019 Apr 16.

Surveillance and Health Services Research, American Cancer Society, Atlanta, GA, United States of America.

Recent trends of cervical cancer incidence by histology and age in the United States (U.S.) have not been reported. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.04.010DOI Listing

Chronic cough and gastroesophageal reflux in children - CHEST Guideline and Expert Panel Report.

Chest 2019 Apr 16. Epub 2019 Apr 16.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, UMass Memorial Medical Center, Worcester, MA, USA.

Background: Whether gastroesophageal reflux (GER) or GER disease (GERD) causes chronic cough in children is controversial. Using the PICO format, we undertook 4 systematic reviews. For children with chronic cough (>4-weeks duration) and without underlying lung disease: (1) who do not have gastrointestinal GER symptoms, should empirical treatment for GERD be used? (2) with gastrointestinal GER symptoms, does treatment for GERD resolve the cough? (3) with or without gastrointestinal GER symptoms, what GER-based therapies should be used and for how long? (4) if GERD is suspected as the cause, what investigations and diagnostic criteria best determine GERD as the cause of the cough?

Methods: We used the CHEST Expert Cough Panel's protocol and American College of Chest Physicians (CHEST) methodological guidelines and GRADE framework. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00123692193083
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http://dx.doi.org/10.1016/j.chest.2019.03.035DOI Listing
April 2019
1 Read
7.483 Impact Factor

A Remarkable Legacy: The Wayne F. Placek Fund Grant Program.

J Homosex 2019 Apr 19:1-10. Epub 2019 Apr 19.

c Executive Vice President/Executive Director , American Psychological Foundation , Washington , DC.

Gregory M. Herek, PhD, made an important professional contribution through his service as chair of the Scientific Review Committee of the Wayne F. Placek Fund of the American Psychological Foundation (APF). Read More

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https://www.tandfonline.com/doi/full/10.1080/00918369.2019.1
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http://dx.doi.org/10.1080/00918369.2019.1601437DOI Listing
April 2019
1 Read

Managing costs and care for chronic idiopathic constipation.

Authors:
Dana McCormick

Am J Manag Care 2019 Mar;25(4 Suppl):S63-S69

Director of Pharmacy, Blue Cross Blue Shield of Texas, Richardson, TX. Email:

For decades, chronic idiopathic constipation (CIC) has been one of the most common chronic functional gastrointestinal disorders encountered by clinicians. Common comorbidities include depression, diabetes, functional dyspepsia, hypothyroidism, overweight, obesity, and neurological disorders. CIC imposes a large economic burden on the American healthcare system with estimated costs of $1912 to $7522 in 2007 US dollars per patient per year. Read More

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March 2019
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Making it stick: A CURE designed to introduce students to the scientific process and the host response to foreign materials.

Biochem Mol Biol Educ 2019 Apr 19. Epub 2019 Apr 19.

Department of Biology, Penn State University, Lehigh Valley, Center Valley, Pennsylvania 18034.

Often overlooked in many molecular cell biology laboratory and cell culture courses, suspension cells represent an important aspect of molecular cell biology and cell culture. Most primary cell cultures and cell lines are adherent cells which grow in monolayers on surfaces. However, other cells such as hematopoietic cells, certain tumor cells, and cells of the immune system are suspension cells which are anchorage-independent which grow and divide in solution. Read More

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http://dx.doi.org/10.1002/bmb.21248DOI Listing

Management of Clostridioides (formerly Clostridium) difficile infection (CDI) in Solid Organ Transplant Recipients: Guidelines from the American Society of Transplantation Community of Practice.

Clin Transplant 2019 Apr 19:e13564. Epub 2019 Apr 19.

Department of Medicine, Washington University School of Medicine, St. Louis, MO.

These updated guidelines from the American Society of Transplantation Infectious Diseases Community of Practice address the prevention and management of Clostridium difficile infection in solid organ transplant (SOT) recipients. Clostridioides (formerly Clostridium) difficile infection (CDI) is among the most common hospital acquired infections. In SOT recipients the incidence of CDI varies by type and number or organs transplanted. Read More

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http://dx.doi.org/10.1111/ctr.13564DOI Listing

Vaccination of Solid Organ Transplant Candidates and Recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

Clin Transplant 2019 Apr 19:e13563. Epub 2019 Apr 19.

Transplant Infectious Diseases, University Health Network, Toronto, ON.

These updated guidelines of the AST IDCOP review vaccination of solid organ transplant candidates and recipients. General principles of vaccination as well as the use of specific vaccines in this population are discussed. Vaccination should be reviewed in the pre-transplant setting and appropriate vaccines updated. Read More

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http://dx.doi.org/10.1111/ctr.13563DOI Listing

Genetic Control of Facultative Parthenocarpy in Nicotiana tabacum L.

J Hered 2019 Apr 19. Epub 2019 Apr 19.

North Carolina State University, Department of Crop and Soil Science, Raleigh, NC, USA.

Investigation of parthenocarpy, the production of fruit without fertilization, in multiple plant species could result in development of technologies for conferring seedless fruits and increased stability of fruit formation in economically important plants. We studied parthenocarpy in the model species Nicotiana tabacum L., and observed variability for expression of the trait amongst diverse genetic materials. Read More

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https://academic.oup.com/jhered/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/jhered/esz025DOI Listing
April 2019
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Attitudes towards unions through a generational cohort lens.

J Soc Psychol 2019 ;159(2):190-209

a Carleton University.

Studying a large American union, we report on findings from two studies investigating perceptions of and attitudes towards unions through a generational cohort lens. Study one explores the link between generational cohort and members' perceptions of unions, employing qualitative analysis of 100 interviews: 30 Millennials, 35 Gen X, and 35 Baby Boomers. Analysis determined that union members focus on either ideological or instrumental explanations to support perceptions that their generation was either pro-union or anti-union. Read More

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https://www.tandfonline.com/doi/full/10.1080/00224545.2019.1
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http://dx.doi.org/10.1080/00224545.2019.1570906DOI Listing
January 2019
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Treatment with apolipoprotein A1 protects mice against doxorubicin-induced cardiotoxicity in a scavenger receptor class B type I dependent manner.

Am J Physiol Heart Circ Physiol 2019 Apr 19. Epub 2019 Apr 19.

Biochemistry and Biomedical Sciences; and Thrombosis and Atherosclerosis Research Institute, McMaster University, Canada.

Doxorubicin, an agent used to treat a variety of cancers, is cardiotoxic by triggering cardiomyocyte apoptosis. We previously showed that treating cultured cardiomyocytes with human high density lipoprotein in vitro or transgenic overexpression of human apolipoprotein A1, its main structural protein protects against doxorubicin induced cardiomyocyte apoptosis in a manner dependent on the scavenger receptor class B type I [Durham (2018) 314: H31-H44]. This was due to high density lipoprotein induced activation of Akt signaling in cardiomyocytes. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00432.2018
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http://dx.doi.org/10.1152/ajpheart.00432.2018DOI Listing
April 2019
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CARDIAC INVOLVEMENT IN Beta-THALASSAEMIA: Current treatment strategies.

Postgrad Med 2019 Apr 19. Epub 2019 Apr 19.

e Department of Medicine , Sultan Qaboos University Hospital , Muscat , Oman.

Despite the advances in the management of thalassaemia major, heart disease remains the leading cause of mortality in patients afflicted with this disorder. Cardiac involvement in thalassaemia encompasses a spectrum of disorders including myocardial dysfunction, arrhythmias, pulmonary hypertension and peripheral vascular disease. Although cardiac siderosis (accumulation of iron in cardiac myocytes) as a consequence of repeated blood transfusions is deemed to be the main aetiologic factor for myocardial dysfunction in transfusion dependent patients, the significance of other pathophysiologic mechanisms is being increasingly recognized especially in non-transfusion dependent patients. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1608071DOI Listing
April 2019
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POLYBROMINATED DIPHENYL ETHERS AND BIPHENYL IN SERUM - TIME TREND STUDY FROM THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY FOR YEARS 2005/06 THROUGH 2013/14.

Environ Sci Technol 2019 Apr 19. Epub 2019 Apr 19.

Eleven polybrominated diphenyl ether (tri- to decaBDE) congeners and 2,2',4,4',5,5'-hexabromobiphenyl (BB153) have been measured in pooled samples from the National Health and Nutrition Examination Survey (NHANES) for one decade (from survey years 2005/06 through 2013/14). The pools, which are representative of the general noninstitutionalized population of the United States, encompassed thirty-two demographic groups defined by sex, race/ethnicity (Mexican American, non-Hispanic black, non-Hispanic white, all other race/ethnicities), and age (12-19, >20-39, >40-59, ≥60 years). The adjusted geometric means were determined for the six congeners (BDE28, BDE47, BDE99, BDE100, BDE153, BB153) with detectable concentrations in at least 60% of pools in each of the thirty-two demographic groups; the level of significance for pairwise comparisons thereof were determined. Read More

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http://dx.doi.org/10.1021/acs.est.9b00471DOI Listing

A freshwater analog for the production of Epiphyton-like microfossils.

Geobiology 2019 Apr 19. Epub 2019 Apr 19.

Department of Earth and Climate Sciences, San Francisco State University, San Francisco, California.

Calcified microbial microfossils-often interpreted as cyanobacteria-were important components of Precambrian and Paleozoic limestones, but their paucity in modern marine environments complicates our ability to make conclusive interpretations about their taxonomic affinity and geologic significance. Freshwater spring-associated limestones (e.g. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/gbi.12341
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http://dx.doi.org/10.1111/gbi.12341DOI Listing
April 2019
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American Head and Neck Society Endocrine Surgery Section update on parathyroid imaging for surgical candidates with primary hyperparathyroidism.

Head Neck 2019 Apr 19. Epub 2019 Apr 19.

Division of Head and Neck Endocrine Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.

Health care consumer organizations and insurance companies increasingly are scrutinizing value when considering reimbursement policies for medical interventions. Recently, members of several American Academy of Otolaryngology-Head & Neck Surgery (AAO-HNS) committees worked closely with one insurance company to refine reimbursement policies for preoperative localization imaging in patients undergoing surgery for primary hyperparathyroidism. This endeavor led to an AAO-HNS parathyroid imaging consensus statement (https://www. Read More

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http://dx.doi.org/10.1002/hed.25781DOI Listing

Training Pediatric Residents in Literacy Promotion: Residency Directors' Perspectives.

Teach Learn Med 2019 Apr 19:1-8. Epub 2019 Apr 19.

a The Department of Pediatrics , Rutgers Robert Wood Johnson Medical School , New Brunswick , New Jersey , USA.

Phenomenon: The American Academy of Pediatrics and Canadian Pediatric Society recommend that pediatricians incorporate literacy promotion during well child care, but literacy promotion education during pediatric training remains understudied. We sought to understand how literacy promotion training is currently implemented in pediatric residency programs from the perspective of program directors. Approach: We conducted semistructured interviews with all 9 residency program directors in 1 state. Read More

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http://dx.doi.org/10.1080/10401334.2019.1598866DOI Listing
April 2019
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Streamlining Evaluation and Management Payment to Reduce Clinician Burden.

Circ Cardiovasc Qual Outcomes 2019 Apr;12(4):e005426

American College of Cardiology, Regulatory Affairs, Washington, DC (J.J.V.).

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https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.118.005
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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005426DOI Listing
April 2019
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Underlying liver disease and advanced stage liver cancer are associated with elevated neutrophil-lymphocyte ratio.

Clin Mol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Cancer Center, University of Hawaii, Honolulu, HI, USA.

Background/aims: Inflammation-based scores, such as the neutrophil-to-lymphocyte ratio (NLR), have been associated with prognosis in hepatocellular carcinoma (HCC); but variable cut-off values and potential lack of specificity have limited the utility of NLR. This study evaluates NLR in a large cohort of HCC patients.

Methods: We retrospectively reviewed 789 HCC cases (1993-2017) for demographics, tumor characteristics, treatment, and survival. Read More

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http://dx.doi.org/10.3350/cmh.2019.0004DOI Listing
April 2019
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