106 results match your criteria American journal of clinical and experimental urology[Journal]


Impact of α-adrenoceptor antagonists on prostate cancer development, progression and prevention.

Am J Clin Exp Urol 2019 18;7(1):46-60. Epub 2019 Feb 18.

Department of Urology, University of Kentucky College of Medicine Lexington, Kentucky 40536, USA.

Two decades following the discovery that α1-adrenoceptor antagonists suppress prostate tumor growth at the molecular and cellular level, the impact of α-blockade as re-purposed treatment strategy in the medical management of prostate cancer is gradually being recognized. Prostate cancer is the second most common cause of cancer deaths among males in the United States, yet the disease maintains inconsistent recommendations for prevention and screening. The functional relationship between α-adrenergic signaling and smooth muscle cells in the stroma of the prostate gland and the bladder neck empowered the use of α-adrenoceptor antagonists for the relief of urethral obstruction and clinical symptoms associated with benign prostatic hyperplasia (BPH). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420703PMC
February 2019
1 Read

Interferon-induced IFIT5 promotes epithelial-to-mesenchymal transition leading to renal cancer invasion.

Am J Clin Exp Urol 2019 18;7(1):31-45. Epub 2019 Feb 18.

Department of Urology, University of Texas Southwestern Medical Center Dallas, TX 75390, USA.

Interferon is known as a pleiotropic factor in innate immunity, cancer immunity and therapy. Despite an objective short-term response of interferon (IFN) therapy in renal cell carcinoma (RCC) patients, the potential adverse effect of IFN on RCC cells is not fully understood. In this study, we demonstrate that IFNs can enhance RCC invasion via a new mechanism of IFIT5-mediated tumor suppressor microRNA (miRNA) degradation resulted in the elevation of Slug and ZEB1 and epithelial-to-mesenchymal transition (EMT). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420704PMC
February 2019
1 Read

Role of pre- ( and ) in regulation of gene expression and molecular pathogenesis in renal cell carcinoma.

Am J Clin Exp Urol 2019 18;7(1):11-30. Epub 2019 Feb 18.

Department of Functional Genomics, Chiba University Graduate School of Medicine Chiba, Japan.

Analyses of our previously determined microRNA (miRNA) expression signature of renal cell carcinoma (RCC) and The Cancer Genome Atlas (TCGA) database revealed that both strands of the pre- (the guide strand) and (the passenger strand)- are closely associated with poor prognosis of RCC patients ( = 0.0411 and = 0.022, respectively). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420701PMC
February 2019
1 Read

Association between oral pathogens and prostate cancer: building the relationship.

Am J Clin Exp Urol 2019 18;7(1):1-10. Epub 2019 Feb 18.

Department of Urology, Case Western Reserve University, School of Dental Medicine Cleveland 44106, Ohio.

Background: Chronic inflammation and infections are associated with increased risk of prostate cancer development. There is considerable evidence that proves the interrelationship between bacterial/viral infections and carcinogenesis. Periodontitis is a chronic inflammatory disease triggered by gram-negative anaerobic bacteria. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420702PMC
February 2019

Development of a murine intravesical orthotopic human bladder cancer (mio-hBC) model.

Am J Clin Exp Urol 2018 20;6(6):245-259. Epub 2018 Dec 20.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia Vancouver, BC, Canada.

We have developed a murine intravesical orthotopic human bladder cancer (mio-hBC) model for the establishment of superficial urothelial cell carcinomas. In this model we catheterize female atyhmic nude mice and pre-treat the bladder with poly-L-lysine for 15 minutes, followed by intravesical instillation of luciferase-transfected human UM-UC-3 cells. Cancer cells are quantified by bioluminescent imaging which has been validated by small animal ultrasound. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334200PMC
December 2018
12 Reads

Concurrent EAF2 and ELL2 loss phenocopies individual EAF2 or ELL2 loss in prostate cancer cells and murine prostate.

Am J Clin Exp Urol 2018 20;6(6):234-244. Epub 2018 Dec 20.

University of Pittsburgh Cancer Institute, School of Medicine, University of Pittsburgh Pittsburgh, PA, USA.

Elongation factor for RNA polymerase II 2 (ELL2) and ELL-associated factor 2 (EAF2) are two functionally related androgen responsive gene-encoded proteins with prostate tumor suppressor characteristics. EAF2 and ELL2 have both been shown to be down-regulated in advanced prostate cancer, and mice with either or deficiency developed murine prostatic intraepithelial neoplasia (mPIN), increased cellular proliferation and increased vascularity. Functional studies have revealed that EAF2 and ELL2 can bind to each other and have similar roles in regulating cell proliferation, angiogenesis and prostate homeostasis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334201PMC
December 2018

Concordant miRNA and mRNA expression profiles in humans and mice with bladder outlet obstruction.

Am J Clin Exp Urol 2018 20;6(6):219-233. Epub 2018 Dec 20.

Urology Research Laboratory, Department of Clinical Research, University of Bern Switzerland.

Bladder outlet obstruction (BOO) leads to lower urinary tract symptoms (LUTS) and urodynamic changes of the bladder function. Previously we identified microRNA (miRNA) and mRNA expression profiles associated with different states of BOO-induced LUTD in human patients. Bladder wall remodeling resulting from obstruction is widely studied in animal models of experimentally-induced partial BOO (pBOO). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334198PMC
December 2018
2 Reads

DNA methylation in development and disease: an overview for prostate researchers.

Am J Clin Exp Urol 2018 20;6(6):197-218. Epub 2018 Dec 20.

Department of Comparative Biosciences, University of Wisconsin-Madison Madison, WI 53706, USA.

Epigenetic mechanisms including DNA methylation are critical regulators of organismal development and tissue homeostasis. DNA methylation is the transfer of methyl groups to cytosines, which adds an additional layer of complexity to the genome. DNA methylation marks are recognized by the cellular machinery to regulate transcription. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334199PMC
December 2018

Voided volumes predict degree of partial bladder outlet obstruction in a murine model.

Am J Clin Exp Urol 2018 20;6(5):189-196. Epub 2018 Oct 20.

Department of Pediatric Urology, Ann & Robert H. Lurie Children's Hospital of Chicago 225 E. Chicago Ave., Chicago, IL 60611, USA.

The partial bladder outlet obstruction animal model (pBOO) is commonly used as a model for obstructive uropathy. Unfortunately, pBOO demonstrates variable degrees of obstruction requiring bladder weight (BW) or urodynamic studies to determine true obstruction. Our objective is to identify extent of obstruction by correlating early post-operative Void Stains on Paper (VSOP) assays with ultimate BW in mice. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261872PMC
October 2018
16 Reads

NKX3.1 and PSMA are sensitive diagnostic markers for prostatic carcinoma in bone metastasis after decalcification of specimens.

Am J Clin Exp Urol 2018 20;6(5):182-188. Epub 2018 Oct 20.

Department of Pathology, School of Medicine, New York University New York, NY, USA.

Background: Prostate specific antigen (PSA), prostate specific membrane antigen (PSMA), and NKX3.1 are sensitive and prostate-specific markers frequently used for the diagnosis of metastatic prostate cancer (mPCa). International Society of Urological Pathology recommends use of PSA as the initial immunohistochemical (IHC) marker to identify PCa. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261873PMC
October 2018
8 Reads

Foxa2 activates the transcription of androgen receptor target genes in castrate resistant prostatic tumors.

Am J Clin Exp Urol 2018 20;6(5):172-181. Epub 2018 Oct 20.

Department of Biochemistry and Molecular Biology, LSU Health Sciences Center Shreveport, Louisiana 71103, USA.

Prostate cancer (PCa) is the leading cancer among men. Androgen Deprivation Therapy (ADT) is a common treatment for advanced PCa. However, ADT eventually fails and PCa relapses, developing into castration-resistant prostate cancer (CRPCa). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261871PMC
October 2018
29 Reads

Androgen represses opioid growth factor receptor (OGFR) in human prostate cancer LNCaP cells and OGFR expression in human prostate cancer tissue.

Am J Clin Exp Urol 2018 20;6(4):164-171. Epub 2018 Aug 20.

Department of Pathology, College of Medicine, The Pennsylvania State University Hershey PA, USA.

Opioid receptors are G protein-coupled receptors that bind opioid ligands including endorphins and enkephalins. The existence of a number of opioid receptors, including the mu-opioid receptor (OPRM1), delta-opioid receptor (OPRD1), kappa-opioid receptor (OPRK1) and zeta-opioid receptor (OGFR) have been reported. However, the potential expression and role of these receptors on human prostate carcinogenesis is unknown. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146159PMC

WNT2 is necessary for normal prostate gland cyto-differentiation and modulates prostate growth in an FGF10 dependent manner.

Am J Clin Exp Urol 2018 20;6(4):154-163. Epub 2018 Aug 20.

Department of Urology, College of Medicine, University of Illinois at Chicago Chicago, IL 60612, USA.

Wnt proteins are highly conserved secreted morphogens that function in organ development across species. This study investigates the role(s) of Wnt2 during prostate gland development. mRNA ontogeny in the rat ventral prostate rapidly declines in expression from peak value at post-natal day (pnd) 1 to nadir levels sustained through adulthood. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146160PMC
August 2018
2 Reads

Semen analysis in patients treated for varicocele in pediatric age: are surgical outcomes enough to preserve the fertility potential?

Am J Clin Exp Urol 2018 15;6(3):149-153. Epub 2018 Jun 15.

Department of Pediatric Surgery, Paediatric Fertility Lab, Azienda Ospedaliera Universitaria Integrata, University of Verona, Woman and Child Hospital Piazzale A. Stefani 1, Verona, Italy.

Preserving the fertility potential of adolescent patients with varicocele is still the main outcome of pediatric and adolescent urologysts; the aim of this study is to assess the fertility potential of patients treated for varicocele with testicular hypotrophy in absence of post-operative complications, with complete ipsilateral testicular catch-up growth and normal hormonal values.

Methods: The Authors collected data from adolescents with varicocele aged between 10 and 16 years treated at their Institution between September 2010 and September 2015. Inclusion and exclusion criteria were created; all patients were followed clinically and with hormonal tests before and after surgery and then re-evaluated after semen analysis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055073PMC
June 2018
2 Reads

Transcriptional changes associated with growth of muscle-invasive bladder cancer cell lines in nude mice.

Am J Clin Exp Urol 2018 15;6(3):138-148. Epub 2018 Jun 15.

Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute Buffalo, NY 14263, USA.

Cancer cells set in motion transcriptomic programs allowing for adaptation and growth in immunocompromised mice to form xenografts, a frequently used tool in cancer research. 2D cultures may not be representative of tumors growing in a complex host microenvironment. This can result in different responses to the same agent tested and which impedes the process of developing novel therapeutics. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055076PMC
June 2018
14 Reads

Post-operative use of human chorionic gonadotrophin (u-hCG) inpatients treated for intrabdominal unilateral undescended testes.

Am J Clin Exp Urol 2018 15;6(3):133-137. Epub 2018 Jun 15.

Department of Pediatric Surgical Unit, Azienda Ospedaliera Universitaria Integrata, University of Verona, Woman and Child Hospital Stefani 37100, Verona, Italy.

Objective: To report our experience with post-operative use of human chorionic gonadotrophin to achieve higher testicular volume and function, respect to untreated patients.

Materials And Methods: A prospective study was done using subjects who underwent orchidopexy between Sptember 2010 and September 2016 for unilateral intrabdominal undescended testes. All patients were treated by the same surgeon with laparoscopic one-stage Fowler-Stephens technique. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055077PMC
June 2018
12 Reads

The impact of celecoxib on outcomes in advanced prostate cancer patients undergoing androgen deprivation therapy.

Am J Clin Exp Urol 2018 15;6(3):123-132. Epub 2018 Jun 15.

Department of Urology, University of Wisconsin School of Medicine and Public Health Madison, WI.

Recent work suggests the selective Cox-2 inhibitor celecoxib delays progression to androgen independence in hormone sensitive prostate cancer (HSPC) through inhibition of the androgen receptor (AR) and ErbB signaling. However, human studies examining its effect on delaying disease progression while on hormone therapy are limited. This study explores the effect of celecoxib use on PC survival in VA patients undergoing androgen deprivation therapy (ADT) for advanced PC. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055075PMC
June 2018
1 Read

Interleukin-17 promotes metastasis in an immunocompetent orthotopic mouse model of prostate cancer.

Am J Clin Exp Urol 2018 15;6(3):114-122. Epub 2018 Jun 15.

Department of Structural and Cellular Biology, Tulane University New Orleans 70112, Louisiana.

Metastasis of prostate cancer causes substantial morbidity and mortality. The role of chronic inflammatory factors in promoting the development of prostate cancer metastasis remains unexamined due to a lack of immunocompetent animal models. Here we report an orthotopic mouse allograft model of prostate cancer that was used to assess interleukin-17's role in prostate cancer metastasis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055074PMC
June 2018
4 Reads

The structure of the nucleus in normal and neoplastic prostate cells: untangling the role of type 2 DNA topoisomerases.

Am J Clin Exp Urol 2018 1;6(2):107-113. Epub 2018 Apr 1.

Sidney Kimmel Comprehensive Cancer Center and Brady Urological Institute, Johns Hopkins University School of MedicineBaltimore, MD 21218, USA.

Donald S. Coffey, a pioneer in the study of the structural basis of mammalian genome organization, was fascinated by DNA topoisomerases, chemo-mechanical enzymes that could catalyze changes in DNA structure. Work initiated in his laboratory and carried on with his influence and inspiration has led to the elucidation of specific roles for each of the two type 2 topoisomerases in DNA replication, RNA transcription, and androgen action in prostate cells. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902729PMC
April 2018
3 Reads

A brief history of intracrine androgen metabolism by castration-recurrent prostate cancer.

Authors:
James L Mohler

Am J Clin Exp Urol 2018 1;6(2):101-106. Epub 2018 Apr 1.

Department of Urology, Roswell Park Comprehensive Cancer CenterBuffalo, NY, USA.

This mini-review describes the evolution of the concept of intracrine androgen metabolism by prostate cancer during androgen deprivation therapy. Persistence of androgen receptor protein in the face of castrate circulating levels of testosterone could not be explained fully by hypersensitization or mutation of the androgen receptor. The hypothesis that castration-recurrent prostate cancer produced its own testosterone was proven using radioimmunoassay and mass spectrometry methods adopted for use in prostate tissue. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902728PMC
April 2018
1 Read

Cancer telomeres and white crows.

Authors:
Alan K Meeker

Am J Clin Exp Urol 2018 1;6(2):93-100. Epub 2018 Apr 1.

The Department of Pathology, Johns Hopkins School of MedicineBaltimore, MD, USA.

This mini-review article discusses past and present prostate-focused research on telomere and telomerase biology conducted at Johns Hopkins, through the eyes of a Donald S Coffey trainee. Included are past discoveries of abnormalities in telomere biology in the context of prostate cancer and its pre-malignant precursor prostatic intraepithelial neoplasia (PIN); the finding that telomerase activity is androgen-regulated in the prostate, and the potential role of telomerase in prostate epithelial stem cells. Also reviewed are more recent results showing that in situ telomere length measurements in patient tissue specimens may have utility in risk assessment and as a prognostic biomarker. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902727PMC
April 2018
1 Read

Organization of sperm DNA by the nuclear matrix.

Am J Clin Exp Urol 2018 1;6(2):87-92. Epub 2018 Apr 1.

Department of Anatomy, Biochemistry and Physiology, Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii at Manoa1960 East-West Rd., Honolulu, HI 96822, USA.

In early years, Dr. Donald S. Coffey fostered the development of a new model for the organization of DNA in the sperm nucleus that had many unexpected similarities to that of somatic cells. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902726PMC
April 2018
1 Read

Aptamers and apple pies: a mini-review of PSMA aptamers and lessons from Donald S. Coffey.

Authors:
Shawn E Lupold

Am J Clin Exp Urol 2018 1;6(2):78-86. Epub 2018 Apr 1.

The James Buchanan Brady Urologic Institute and Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA; The Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins UniversityBaltimore, MD, USA.

This mini-review article is part of a special issue dedicated to Donald S. Coffey, a pioneer translational research scientist, exemplary mentor, and leader in urologic and urologic oncology research. This article first briefly reflects on life and scientific lessons from Don Coffey. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902725PMC
April 2018
1 Read

Androgen action in prostate function and disease.

Am J Clin Exp Urol 2018 1;6(2):62-77. Epub 2018 Apr 1.

Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public HealthBaltimore, Maryland 21205, USA.

Benign prostatic hyperplasia (BPH) is an enlargement of the prostate gland that is frequently found in aging men. Androgens are essential for the development and differentiated function of the prostate, as well as for proliferation and survival of prostatic cells. In man, dog and rodent, there are age-related decreases in serum testosterone. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902724PMC

Resolving the Coffey Paradox: what does the androgen receptor do in normal vs. malignant prostate epithelial cells?

Authors:
John T Isaacs

Am J Clin Exp Urol 2018 1;6(2):55-61. Epub 2018 Apr 1.

Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsBaltimore, MD 21231, USA.

Donald Straley Coffey completed his 85 year life's journey on November 9, 2017. In his wake, he left a legion of inspired and loyal students, fellows, and faculty colleagues from all over the world to carry on his passion both for life in general and his 50 year quest to conquer cancer. Early in his career, Dr. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902723PMC
April 2018
2 Reads

Structure and function analysis in circulating tumor cells: using nanotechnology to study nuclear size in prostate cancer.

Am J Clin Exp Urol 2018 1;6(2):43-54. Epub 2018 Apr 1.

Urologic Oncology Program & Uro-Oncology Laboratories, Samuel Oschin Comprehensive Cancer InstituteLos Angeles, CA 90048, USA.

Professor Donald Coffey and his laboratory pioneered studies showing the relationships between nuclear shape and cellular function. In doing so, he and his students established the field of nuclear morphometry in prostate cancer. By using perioperative tissues via biopsies and surgical sampling, Dr. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902722PMC
April 2018
4 Reads

Donald S Coffey, a man who meant so much to so many.

Authors:
William Isaacs

Am J Clin Exp Urol 2018 1;6(2):41-42. Epub 2018 Apr 1.

Brady Urological Institute and Department of Urology, School of Medicine, Johns Hopkins University600 Wolfe St., Baltimore, MD 21287-2101, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902721PMC

Two minds create a third: an exploration of the universe, cancer, and symmetry with Donald S. Coffey.

Authors:
J James Frost

Am J Clin Exp Urol 2018 1;6(2):37-40. Epub 2018 Apr 1.

Department of Radiology, The John Hopkins University, BioMolecular Imaging, LLCBaltimore, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902720PMC

Allowing awe in life.

Authors:
Daniel E Epner

Am J Clin Exp Urol 2018 1;6(2):32-36. Epub 2018 Apr 1.

Department of Palliative, Rehabilitation, and Integrative Medicine, University of Texas MD Anderson Cancer CenterHouston Texas, 1400 Pressler, Unit 1414, Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902719PMC
April 2018
6 Reads

Ten unanswered questions in cancer: "If this is true, what does it imply"?

Am J Clin Exp Urol 2018 1;6(2):26-31. Epub 2018 Apr 1.

The James Buchanan Brady Urologic Institute and Department of Urology, Johns Hopkins School of MedicineBaltimore, MD 21287, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902718PMC
April 2018
3 Reads

Donald S. Coffey, the Brady Long Rifles, and the war on prostate cancer.

Authors:
Markham C Luke

Am J Clin Exp Urol 2018 1;6(2):23-25. Epub 2018 Apr 1.

Division of Therapeutic Performance, Office of Research and Standards, Office of Generic Drugs, U.S. Food and Drug AdministrationSilver Spring, Maryland 20993, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902717PMC

Dr. Coffey's visionary contributions to urological research in China and Japan.

Am J Clin Exp Urol 2018 1;6(2):15-22. Epub 2018 Apr 1.

Department of Urology, Graduate School of Medicine, Chiba UniversityChiba, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902716PMC
April 2018
3 Reads

BCL-2 and BCL-XL expression are down-regulated in benign prostate hyperplasia nodules and not affected by finasteride and/or celecoxib.

Am J Clin Exp Urol 2018 5;6(1):1-10. Epub 2018 Feb 5.

Department of Urology, University of Pittsburgh School of MedicinePittsburgh 15232, PA, USA.

The mechanisms involved in the development of benign prostatic hyperplasia (BPH) are poorly understood. One potential mechanism involved in BPH pathogenesis may involve altered expression of genes related to apoptosis and proliferation because reduced cell death and increased proliferation are thought to contribute to prostatic enlargement. This study examined the expression of B-cell lymphoma 2 (BCL-2) and B-cell lymphoma-extra large (BCL-XL), two important anti-apoptosis factors that are also capable of inhibiting cell proliferation via accelerated G1 arrest or delayed G1/S transition, using immunostaining in simple prostatectomy BPH specimens from patients naïve to androgen manipulation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840285PMC
February 2018
16 Reads

Parsley! Mechanism as antiurolithiasis remedy.

Am J Clin Exp Urol 2017 9;5(3):55-62. Epub 2017 Nov 9.

Department of Biology, Faculty of Science, Sana'a UniversityYemen.

Parsley is a medicinal plant used widely in urolithiasis. The present study aimed to evaluate the antiurolithiatic effect of parsley and its mechanism. 24 rats divided into four groups: group A (negative control), group B (positive control), group C (cystone group) and group D (parsley group). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698599PMC
November 2017
6 Reads

Clinical features of patients treated by peritoneal dialysis for over a decade.

Am J Clin Exp Urol 2017 9;5(3):49-54. Epub 2017 Nov 9.

Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, Technology, Karolinska InstitutetStockholm, Sweden.

Background: Peritoneal dialysis (PD) is well-established as renal replacement therapy in end stage renal disease and has survival rates similar or better than hemodialysis (HD) for the initial years on dialysis therapy. However retention rate is lower due to higher technique failure rates than in HD and few patients stay on PD for more than 10 years (PD). Here we investigated clinical features characterizing PD patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698598PMC
November 2017
7 Reads

Molecular mechanisms involving prostate cancer racial disparity.

Am J Clin Exp Urol 2017 9;5(3):34-48. Epub 2017 Nov 9.

Department of Pathology, New York University School of MedicineNew York, NY, USA.

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in the United States. The African (AA) descent has greater incidence and mortality rates of PCa as compared to Caucasian (CA) men. While socioeconomic differences across racial groups contribute to disparity in PCa, increasing evidence points that genetic and molecular alterations play important roles in racial disparities associated with PCa. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698597PMC
November 2017
3 Reads

Organoid culture of human prostate cancer cell lines LNCaP and C4-2B.

Am J Clin Exp Urol 2017 9;5(3):25-33. Epub 2017 Nov 9.

Department of Structural & Cellular Biology, Tulane UniversityNew Orleans, LA, USA.

Organoids mimic the architecture and functions of a small organ. Organoid culture technique has been rapidly accepted by all research communities during the past decade to study stem cells, organ development and function, and patient-specific diseases. A protocol for organoid culture of human and mouse prostate epithelial and cancer tissues has been reported. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698596PMC
November 2017
11 Reads

Androgen receptor (AR) cistrome in prostate differentiation and cancer progression.

Am J Clin Exp Urol 2017 9;5(3):18-24. Epub 2017 Nov 9.

Department of Biochemistry and Molecular BiologyLSUHSC-S, Shreveport, LA, USA.

Despite the progress in development of better AR-targeted therapies for prostate cancer (PCa), there is no curative therapy for castration-resistant prostate cancer (CRPC). Therapeutic resistance in PCa can be characterized in two broad categories of AR therapy resistance: the first and most prevalent one involves restoration of AR activity despite AR targeted therapy, and the second one involves tumor progression despite blockade of AR activity. As such AR remains the most attractive drug target for CRPC. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698595PMC
November 2017
1 Read

Bladder pain in an LL-37 interstitial cystitis and painful bladder syndrome model.

Am J Clin Exp Urol 2017 1;5(2):10-17. Epub 2017 Sep 1.

Division of Urology, Section of Pediatric Urology, University of UtahSalt Lake City, UT.

Our goal was to evaluate the pain response in an LL-37 induced murine model for interstitial cystitis/painful bladder syndrome (IC/PBS). In particular, we sought to characterize the dose dependence, time-course, and relationship of LL-37 induced bladder inflammation and pain. The IC/PBS model was induced in C57Bl/6 mice by instilling 50 μL of LL-37, an immunomodulatory human cathelicidin (anti-microbial peptide), in the bladder for 1 hr. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636891PMC
September 2017
3 Reads

Obesity, age, ethnicity, and clinical features of prostate cancer patients.

Am J Clin Exp Urol 2017 15;5(1):1-9. Epub 2017 Feb 15.

Department of Structural & Cellular Biology, Tulane UniversityNew Orleans, LA, USA; Department of Orthopaedic Surgery, Tulane UniversityNew Orleans, LA, USA; Tulane Cancer Center and Louisiana Cancer Research Consortium, Tulane UniversityNew Orleans, LA, USA; Tulane Center for Stem Cell Research and Regenerative Medicine, Tulane UniversityNew Orleans, LA, USA; Tulane Center for Aging, Tulane UniversityNew Orleans, LA, USA.

Approximately 36.5% of the U.S. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344988PMC
February 2017
4 Reads

A metastatic castration resistant prostate cancer patient with multiple bone metastases has durable biochemical and radiological response to docetaxel chemotherapy.

Am J Clin Exp Urol 2016 20;4(2):28-31. Epub 2016 Sep 20.

Department of Urology, Keio University School of Medicine 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Docetaxel chemotherapy for metastatic castration resistant prostate cancer patients has been thought palliative because the radiological response rate is low and durable response is rare. The patient was a 64-year-old man who was diagnosed with cT3aN0M0 prostate cancer and underwent external beam radiation therapy as the initial treatment. He underwent androgen deprivation therapy and 8 cycles of docetaxel chemotherapy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069273PMC
September 2016
1 Read

Phase IIa, randomized placebo-controlled trial of single high dose cholecalciferol (vitamin D) and daily Genistein (G-2535) versus double placebo in men with early stage prostate cancer undergoing prostatectomy.

Am J Clin Exp Urol 2016 20;4(2):17-27. Epub 2016 Sep 20.

Department of Medicine, University of Wisconsin School of Medicine and Public HealthMadison, WI, USA; University of Wisconsin Carbone Cancer CenterMadison, WI, USA.

Introduction And Objectives: Prostate cancer (PCa) represents an important target for chemoprevention given its prolonged natural history and high prevalence. Epidemiologic and laboratory data suggest that vitamin D and genistein (soy isoflavone) may decrease PCa progression. The effect of vitamin D on prostate epithelial cell proliferation and differentiation is well documented and genistein may augment this affect through inhibition of the CYP24 enzyme, which is responsible for intracellular vitamin D metabolism. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069272PMC
September 2016
16 Reads

Papillary urothelial carcinoma with squamous differentiation in association with human papilloma virus: case report and literature review.

Am J Clin Exp Urol 2016 28;4(1):12-6. Epub 2016 Jan 28.

Department of Pathology, York University School of MedicineNew York, NY 10010, USA; Department of Veterans Affairs New York Harbor Healthcare SystemNew York, NY 10010, USA.

Background: The human papilloma virus (HPV) is a carcinogen known for its strong association with cervical cancers and cervical lesions. It is also known to be associated with a variety of squamous cell carcinomas in other areas, such as the penis, vulva, anus and head and neck. However, the association with urothelial carcinoma remains controversial. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749403PMC
April 2016
18 Reads

Severe gangrene at the glans penis requiring penectomy as the first major complication of Buerger's disease.

Am J Clin Exp Urol 2016 28;4(1):9-11. Epub 2016 Jan 28.

Department of Urology, University of Massachusetts Medical School Worcester, MA 01605, USA.

We report an interesting case of Buerger's disease that manifested at the glans penis in a 56 year-old former smoker. Penile involvement in Buerger's disease is rare. Our patient had no prior extremity or digit amputations in his 4-year history of Buerger's disease. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749402PMC

PD-1, PD-L1 and PD-L2 expression in mouse prostate cancer.

Am J Clin Exp Urol 2016 28;4(1):1-8. Epub 2016 Jan 28.

Department of Structural and Cellular Biology, Tulane UniversityNew Orleans, LA, USA; Tulane Cancer Center and Louisiana Cancer Research Consortium, Tulane UniversityNew Orleans, LA, USA; Department of Orthopaedic Surgery, Tulane UniversityNew Orleans, LA, USA; Tulane Center for Stem Cell Research and Regenerative Medicine, Tulane UniversityNew Orleans, LA, USA; Tulane Center for Aging, Tulane UniversityNew Orleans, LA, USA.

Programmed cell death protein 1 (PD-1) and its ligands PD-L1 and PD-L2 play critical roles in maintaining an immunosuppressive tumor microenvironment. The purpose of the present study was to assess expression of PD-1, PD-L1, and PD-L2 in mouse prostate tumors. A total of 33 mouse prostate tumors derived from Pten-null mice were examined using immunohistochemical staining for PD-1, PD-L1, and PD-L2. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749401PMC
April 2016
58 Reads

Unilateral hypoplastic kidney and ureter associated with diverse mesonephric remnant hyperplasia.

Am J Clin Exp Urol 2015 8;3(2):107-11. Epub 2015 Aug 8.

Department of Urology, University of Rochester Medical Center Rochester, NY, USA.

Mesonephric remnants have been rarely reported in the genitourinary system and sometimes impose a diagnostic challenge both clinically and pathologically. We reported a case of mesonephric remnant hyperplasia with mixed acinar/tubular and epididymis/vas deferens-like morphologies occurring in the renal parenchyma of a unilateral hypoplastic kidney, which has not been previously described. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539112PMC
August 2015
17 Reads

Mean platelet volume and varicocele: comparison between adolescents and adults.

Am J Clin Exp Urol 2015 8;3(2):100-6. Epub 2015 Aug 8.

Department of Surgery, Pediatric Surgical Unit, University of Verona, Policlinico G.B.Rossi Piazzale L.A.Scuro n.1, 37134 Verona, Italy.

Purpose: To evaluate the association between varicocele and MPV values in pediatric and adult patients. And its association with different clinical parameters.

Materials And Methods: We retrospectively analyzed the medical charts of patients treated for varicocele at our Institution between December 2010 and December 2014. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539111PMC
August 2015
2 Reads

Signaling mechanisms coupled to CXCL12/CXCR4-mediated cellular proliferation are PTEN-dependent.

Am J Clin Exp Urol 2015 8;3(2):91-9. Epub 2015 Aug 8.

Department of Biology, University of Massachusetts Boston Boston, MA.

A key difference between normal and malignant prostate cells in vitro and in vivo is that both alleles of PTEN are largely intact in normal benign prostate glands and cultured epithelial cells, whereas one or both alleles of PTEN are mutant or deleted in the majority of prostate tumors and malignant prostate cancer cell lines. Intact PTEN suppresses phosphorylation of Akt downstream of PI3K activation in non-transformed cells whereas Akt phosphorylation is unimpeded in malignant cells that are often PTEN-deficient. We have previously shown that activation of the CXCL12/CXCR4 axis transactivates the EGFR to promote pro-proliferative signaling preferentially through the Raf/MEK/Erk pathway in benign prostate epithelial cells. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539110PMC
August 2015
10 Reads

Therapeutic challenges in renal cell carcinoma.

Am J Clin Exp Urol 2015 8;3(2):77-90. Epub 2015 Aug 8.

Departments of Urology, Molecular Biochemistry and Pathology, Markey Cancer Center, University of Kentucky College of Medicine Lexington, KY 50536, USA.

Renal cell carcinoma (RCC) is a malignancy that in advanced disease, is highly resistant to systemic therapies. Elucidation of the angiogenesis pathways and their intrinsic signaling interactions with the genetic and metabolic disturbances within renal cell carcinoma variants has ushered in the era of "targeted therapies". Advanced surgical interventions and novel drugs targeting VEGF and mTOR, have improved patient survival and prolonged clinically stable-disease states. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539109PMC
August 2015
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Drug resistance in castration resistant prostate cancer: resistance mechanisms and emerging treatment strategies.

Am J Clin Exp Urol 2015 8;3(2):64-76. Epub 2015 Aug 8.

Department of Urology, University of California at Davis Sacramento, CA, USA ; Comprehensive Cancer Center, University of California at Davis Sacramento, CA, USA.

Several mechanisms facilitate the progression of hormone-sensitive prostate cancer to castration-resistant prostate cancer (CRPC). At present, the approved chemotherapies for CRPC include systemic drugs (docetaxel and cabazitaxel) and agents that target androgen signaling, including enzalutamide and abiraterone. While up to 30% of patients have primary resistance to these treatments, each of these drugs confers a significant survival benefit for many. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539108PMC
August 2015
7 Reads