342,401 results match your criteria American journal of cardiovascular drugs : drugs devices and other interventions[Journal]


Emerging translational science discoveries, clonal approaches and treatment trends in chronic myeloproliferative neoplasms.

Hematol Oncol 2019 Apr 23. Epub 2019 Apr 23.

University of California Irvine, Irvine, CA, USA.

The 60 American Society of Hematology (ASH) held in San Diego in December 2018 was followed by the 13 Post-ASH chronic myeloproliferative neoplasms (MPNs) workshop on the 4 -5 December 2018. This closed annual workshop, first introduced in 2006 by Goldman and Mughal, was organized in collaboration with Alpine Oncology Foundation and allowed experts in preclinical and clinical research in the chronic MPNs to discuss the current scenario, including relevant presentations at ASH, and address pivotal open questions that impact translational research and clinical management. This review is based on the presentations and deliberations at this workshop, and rather than provide a resume of the proceedings, we have selected some of the important translational science and treatment issues which require clarity. Read More

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http://dx.doi.org/10.1002/hon.2622DOI Listing

[Psychometric Properties of the Shortend Version of the "Systems of Belief Inventory" in a Representative Sample of the German Population].

Psychother Psychosom Med Psychol 2019 Apr 23. Epub 2019 Apr 23.

Klinik für Psychosomatik und Psychotherapie, Universitätsklinikum Münster.

Introduction: The aim of the present study was to show the development of the revised and shortened German version (6 items) of the "Systems of Belief Inventory" (SBI-6R-D) as well as to examine its psychometric properties.

Methods: In a representative German sample the questionnaire has been given to 2513 subjects. A confirmatory factor analysis has been made to prove the original American factor structure. Read More

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http://dx.doi.org/10.1055/a-0865-2211DOI Listing

Billed and Paid Amounts for Preventive Procedures in Dental Medicaid.

JDR Clin Trans Res 2019 Apr 23:2380084419842533. Epub 2019 Apr 23.

4 Department of Clinical Services, School of Dentistry, Marquette University, Milwaukee, WI, USA.

Objective: To examine trends and variations in billed and paid amounts for preventive dental procedures by race/ethnicity, age, and sex in Wisconsin dental Medicaid.

Methods: We analyzed data from the 2001 to 2013 Wisconsin Medicaid claims database for preventive dental procedures for children and adults. Billed and paid amounts for preventive dental procedures were aggregated over a visit and adjusted for inflation based on the Medical Care Consumer Price Index produced by the Bureau of Labor Statistics for 2013. Read More

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http://journals.sagepub.com/doi/10.1177/2380084419842533
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http://dx.doi.org/10.1177/2380084419842533DOI Listing
April 2019
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Types of materials for frontalis sling surgery for congenital ptosis.

Cochrane Database Syst Rev 2019 Apr 23;4:CD012725. Epub 2019 Apr 23.

Department of Ophthalmology, Montefiore Medical Center, Albert Einstein College of Medicine, 3332 Rochambeau Avenue, 3rd Floor, Bronx, NY, USA, 10467.

Background: Congenital ptosis is a drooping of one or both eyelids at birth, often due to poor development of the levator palpebrae superioris muscle. This can result in amblyopia, astigmatism, and ocular torticollis and therefore may necessitate surgical intervention in early childhood if visual development is compromised. Patients may have varied levels of levator function. Read More

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http://dx.doi.org/10.1002/14651858.CD012725.pub2DOI Listing

Entrustable Professional Activity Utilization: A CERA Study of Family Medicine Residency Program Directors.

Fam Med 2019 Apr 23. Epub 2019 Apr 23.

Department of Family Medicine, College of Medicine, University of Illinois, Chicago, IL.

Background And Objectives: Entrustable professional activities (EPAs) is a novel assessment framework in competency-based medical education. While there are published pilot reports about utilization and validation of EPAs within undergraduate medical education (UME), there is a paucity of research within graduate medical education (GME). This study aimed to explore the landscape of EPAs within family medicine GME, particularly related to the understanding of EPAs, extent of utilization, and benefits and challenges of EPAs implementation as an assessment framework within family medicine residency programs (FMRPs) in the United States. Read More

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http://dx.doi.org/10.22454/FamMed.2019.876961DOI Listing

The 2016 ASE/EACVI recommendations may be able to more accurately identify patients at risk for diastolic dysfunction in living donor liver transplantation.

PLoS One 2019 23;14(4):e0215603. Epub 2019 Apr 23.

Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: The aim of this study was to compare the prevalence of diastolic dysfunction between the 2016 American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging and 2009 ASE/European Association of Echocardiography recommendations in patients undergoing living-donor liver transplantation (LDLT).

Patients And Methods: A total of 312 adult patients who underwent LDLT at our hospital from January 2010 to December 2017 were retrospectively analyzed. Exclusion criteria were systolic dysfunction, arrhythmia, myocardial ischemia, and mitral or aortic valvular insufficiency. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215603PLOS

An ecological view of measurement: focus on multilevel model explanation of differential item functioning.

Psicothema 2019 May;31(2):194-203

University of British Columbia.

Background: The 3rd Regional Comparative and Explanatory Study reports, analyses and compares academic results in mathematics, sciences, and reading for 15 Latin American countries. Validity is the foundation of a testing procedure, and the process of validation is important to the overall success of educational assessment as a whole. This methodological study deals specifically with an ecological point of view which includes and situates the person, process, context, and time of the testing situation. Read More

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http://dx.doi.org/10.7334/psicothema2018.303DOI Listing

Is GRADE the Right Choice for Clinical Practice Guidelines Developed by the American Academy of Otolaryngology-Head and Neck Surgery Foundation?

Otolaryngol Head Neck Surg 2019 Apr 23:194599819846458. Epub 2019 Apr 23.

2 SUNY Downstate Medical Center, Brooklyn, New York, USA.

Clinical practice guidelines (CPGs), developed to inform clinicians, patients, and policy makers about what constitutes optimal clinical care, are one way of increasing implementation of evidence into clinical practice. Many factors must be considered by multidisciplinary guideline panels, including strength of available evidence, limitations of current knowledge, risks/benefits of interventions, patient values, and limited resources. Grading of Recommendations Assessment, Development and Evaluation (GRADE) is a framework for summarizing evidence that has been endorsed by many national and international organizations for developing CPGs. Read More

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http://dx.doi.org/10.1177/0194599819846458DOI Listing

COMMENTARY FROM THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS ON THE U.S. PREVENTIVE SERVICES TASK FORCE RECOMMANDATIONS REGARDING WEIGHT LOSS INTERVENTIONS.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

Department of Internal Medicine (Endocrinology and Metabolism) and the Department of Pediatrics (Endocrinology), Yale University School of Medicine, New Haven, Connecticut.

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http://journals.aace.com/doi/10.4158/EP-2018-0597
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http://dx.doi.org/10.4158/EP-2018-0597DOI Listing
April 2019
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ASSOCIATIONS BETWEEN VITAMIN D AND MICROVASCULAR COMPLICATIONS IN MIDDLE-AGED AND ELDERLY DIABETIC PATIENTS.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The objective of the cross-sectional study was to investigate the association of serum 25-hydroxyvitamin D [25(OH)D] levels with estimated glomerular filtration rate (eGFR), albuminuria/creatinine ratio (ACR) and the prevalence of diabetic retinopathy (DR) in Chinese diabetic adults. 4,767 diabetic participants were enrolled from seven communities in Shanghai, China in 2018. Participants underwent several checkups, which included the measurement of anthropometric parameters, blood pressure, glucose, lipid profiles, 25(OH)D and ACR. Read More

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http://dx.doi.org/10.4158/EP-2019-0015DOI Listing

Epidemiology of Sudden Death in Organized Youth Sports in the United States, 2007-2015.

J Athl Train 2019 Apr 23. Epub 2019 Apr 23.

Korey Stringer Institute, Department of Kinesiology, University of Connecticut, Storrs.

Context: Sudden death in sport at the high school and collegiate levels has been described extensively in the literature. However, few epidemiologic data exist on the incidence of sudden death specifically in American youth sport before secondary school athletics.

Objective: To describe the epidemiology of sudden death in organized youth sports in the United States from 2007-2015. Read More

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http://dx.doi.org/10.4085/1062-6050-358-18DOI Listing

Management of acute cholecystitis in high-risk patients.

J Hepatobiliary Pancreat Sci 2019 Apr 23. Epub 2019 Apr 23.

Department of Surgery. Hospital, Universitario de Salamanca, Paseo de San Vicente, 88-132, 37007, Salamanca, Spain.

The new flowchart for the management of acute cholecystitis proposed by Okamoto and colleagues does consider not only the grade of cholecystitis but also makes an effort to quantify the surgical risk, of decision making, for the patients. The point is whether or not the tools selected for risk assessment, Charlson comorbidity index (CCI) and the American Society of Anesthesiologists Physical Status (ASA-PS), may offer the best approach to quantify risk. Although CCI has been evaluated for predicting in-hospital mortality, it was designed and widely used for estimating the relationship between life expectancy or long-term mortality and clinical past history, rather than estimating surgical risk. Read More

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http://dx.doi.org/10.1002/jhbp.629DOI Listing

Survival outcomes by high-risk human papillomavirus status in nonoropharyngeal head and neck squamous cell carcinomas: A propensity-scored analysis of the National Cancer Data Base.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.

Background: The prognostic relevance of human papillomavirus (HPV) status in patients with nonoropharyngeal (OPX) squamous cell cancer (SCC) of the head and neck is controversial. In the current study, the authors evaluated the impact of high-risk HPV status on overall survival (OS) in patients with non-OPX SCC using a large database approach.

Methods: The National Cancer Data Base was queried to identify patients diagnosed from 2004 through 2014 with SCC of the OPX, hypopharynx (HPX), larynx, and oral cavity (OC) with known HPV status. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32115
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http://dx.doi.org/10.1002/cncr.32115DOI Listing
April 2019
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The American Joint Committee on Cancer turns 60.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

American Joint Committee on Cancer, Chicago, Illinois.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32159
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http://dx.doi.org/10.1002/cncr.32159DOI Listing
April 2019
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Image-Based Mobile System for Dietary Management in an American Cardiology Population: Pilot Randomized Controlled Trial to Assess the Efficacy of Dietary Coaching Delivered via a Smartphone App Versus Traditional Counseling.

JMIR Mhealth Uhealth 2019 Apr 23;7(4):e10755. Epub 2019 Apr 23.

Department of Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC, United States.

Background: Randomized controlled trials conducted in Mediterranean countries have shown that the Mediterranean diet lowers adverse cardiovascular events. In the American population, diet remains the biggest uncontrolled risk factor for cardiovascular disease.

Objective: This study aimed to test the hypothesis that asynchronous dietary counseling supplied through a custom smartphone app results in better adherence to a Mediterranean diet in a non-Mediterranean population than traditional standard-of-care (SOC) counseling. Read More

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http://dx.doi.org/10.2196/10755DOI Listing

The significance of tumor budding in oral cancer survival and its relevance to the eighth edition of the American Joint Committee on Cancer staging system.

Head Neck 2019 Apr 23. Epub 2019 Apr 23.

Department of Stomatology, Oral & Maxillofacial Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: To explore the clinicopathological significance of tumor budding (TB) on oral squamous cell carcinoma (OSCC) prognosis.

Methods: Data of 200 patients with OSCC were retrieved from the cancer registration database in Taipei Veterans General Hospital. Clinicopathological characteristics and survival relevant to TB were analyzed. Read More

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http://dx.doi.org/10.1002/hed.25780DOI Listing

Noncoding Variations in the Gene Encoding Ceramide Synthase 6 are Associated with Type 2 Diabetes in a Large Indigenous Australian Pedigree.

Twin Res Hum Genet 2019 Apr 23:1-9. Epub 2019 Apr 23.

Diabetes Research Laboratories, School of Clinical Medicine Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine,University of Queensland,Brisbane,Queensland,Australia.

Type 2 diabetes (T2D) is a chronic disease that disproportionately affects Indigenous Australians. We have previously reported the localization of a novel T2D locus by linkage analysis to chromosome 2q24 in a large admixed Indigenous Australian pedigree (Busfield et al. (2002). Read More

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http://dx.doi.org/10.1017/thg.2019.13DOI Listing

Perinatal Risk Factors for the Retinopathy of Prematurity in Postnatal Growth and Rop Study.

Ophthalmic Epidemiol 2019 Apr 23:1-9. Epub 2019 Apr 23.

a Department of Ophthalmology , Scheie Eye Institute, University of Pennsylvania , Philadelphia , Pennsylvania , USA.

Objective: To evaluate perinatal risk factors for retinopathy of prematurity (ROP), in a large, broad-risk cohort of premature infants.

Study Design: Secondary analysis of data from the Postnatal Growth and ROP (G-ROP) Study, a retrospective cohort study of infants undergoing ROP examinations at 29 North American hospitals in 2006-2012.

Results: Among 7483 infants, 3224 (43. Read More

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https://www.tandfonline.com/doi/full/10.1080/09286586.2019.1
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http://dx.doi.org/10.1080/09286586.2019.1606259DOI Listing
April 2019
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Effect of Obesogenic Medications on Weight-Loss Outcomes in a Behavioral Weight-Management Program.

Obesity (Silver Spring) 2019 May;27(5):716-723

Veterans Affairs San Diego Healthcare System, San Diego, California, USA.

Objective: This study aimed to evaluate a possible association between the use of obesogenic medications and inadequate weight loss in a behavioral weight-management program.

Methods: This is a case-control, single-center study of 666 adult patients within a Veterans Health Administration health system who participated in the MOVE! behavioral weight-loss program. The cohort was divided into responders (n = 150), patients who achieved ≥ 5% total weight loss by the end of the MOVE! program, and nonresponders (n = 516), those who achieved < 5% total weight loss. Read More

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http://doi.wiley.com/10.1002/oby.22444
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http://dx.doi.org/10.1002/oby.22444DOI Listing
May 2019
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Curative-intent radiotherapy for pediatric osteosarcoma: The St. Jude experience.

Pediatr Blood Cancer 2019 Apr 22:e27763. Epub 2019 Apr 22.

Departments of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: Radiation therapy (RT) confers local tumor control and survival advantages in some patients with osteosarcoma, yet pediatric and adolescent and young adult (AYA) population studies are limited.

Methods: Twenty-eight patients treated with curative-intent RT (median dose, 59.4 Gy; range, 40-76 Gy) at our institution from 1990 to 2017 were retrospectively identified. Read More

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http://dx.doi.org/10.1002/pbc.27763DOI Listing

Personalized prognostication in head and neck cancer: A systematic review of nomograms according to the AJCC precision medicine core (PMC) criteria.

Head Neck 2019 Apr 23. Epub 2019 Apr 23.

Department of Otolaryngology, Head and Neck Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, New York.

Background: The American Joint Committee on Cancer (AJCC) Precision Medicine Core (PMC) has recognized the need for more personalized probabilistic predictions above the "TNM" staging system and has recently released a checklist of inclusion and exclusion criteria for evaluating prognostic models.

Methods: A systematic review of articles in which nomograms were created for head and neck cancer (HNC) was carried out according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The AJCC PMC criteria were used to score the individual studies. Read More

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http://dx.doi.org/10.1002/hed.25778DOI Listing

Antileismanial activity, mechanism of action study and molecular docking of 1,4-bis(substituted benzalhydrazino)phthalazines.

Arch Pharm (Weinheim) 2019 Apr 23:e1800299. Epub 2019 Apr 23.

Department of Chemistry, University of Florida, Gainesville, Florida.

To identify new agents for the treatment of American cutaneous leishmaniasis, a series of eight 1,4-bis(substituted benzalhydrazino)phthalazines was evaluated against Leishmania braziliensis and Leishmania mexicana parasites. These compounds represent a disubstituted version of the 1-chloro-4-(monoaryl/heteroarylhydranizyl)phthalazine that exhibited a significant response against L. braziliensis according to our previous findings. Read More

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http://dx.doi.org/10.1002/ardp.201800299DOI Listing

Cancer-Associated Malnutrition and CT-Defined Sarcopenia and Myosteatosis Are Endemic in Overweight and Obese Patients.

JPEN J Parenter Enteral Nutr 2019 Apr 22. Epub 2019 Apr 22.

Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.

Background: Overweight/obese patients' large fat mass can mask the loss of skeletal muscle, which is associated with mortality in the oncology setting. We investigated the prevalence of computed tomography (CT)-defined sarcopenia and myosteatosis across different levels of nutrition risk assessed by the Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF). We also evaluated whether the PG-SGA SF, sarcopenia, and myosteatosis were prognostic of overall survival. Read More

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http://dx.doi.org/10.1002/jpen.1597DOI Listing

Low dose 100 cGy irradiation as a potential therapy for pulmonary hypertension.

J Cell Physiol 2019 Apr 22. Epub 2019 Apr 22.

Division of Hematology/Oncology, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Pulmonary hypertension (PH) is an incurable disease characterized by pulmonary vascular remodeling and ultimately death. Two rodent models of PH include treatment with monocrotaline or exposure to a vascular endothelial growth factor receptor inhibitor and hypoxia. Studies in these models indicated that damaged lung cells evolve extracellular vesicles which induce production of progenitors that travel back to the lung and induce PH. Read More

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http://dx.doi.org/10.1002/jcp.28723DOI Listing

A storytelling intervention reduces childhood caries risk behaviors among American Indian and Alaska Native mothers in Northern California.

J Public Health Dent 2019 Apr 23. Epub 2019 Apr 23.

Department of Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA.

Objectives: To evaluate a storytelling intervention targeting the oral health beliefs, knowledge, and behaviors of AIAN pregnant women and mothers.

Methods: Fifty-three adult AIAN women from three tribal communities in Northern California participated. The intervention story delivered oral health messaging using a traditional storytelling format. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jphd.12318
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http://dx.doi.org/10.1111/jphd.12318DOI Listing
April 2019
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The Evaluation of the Eighth Edition of the AJCC/UICC Staging System for Intrahepatic Cholangiocarcinoma: a Proposal of a Modified New Staging System.

J Gastrointest Surg 2019 Apr 22. Epub 2019 Apr 22.

Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, 1007, Shimo-Nagakubo, Sunto-Nagaizumi, Shizuoka, 4118777, Japan.

Background: The objective was to clarify the prognostic impact of the 8th edition of American Joint Committee on Cancer (AJCC)/International Union Against Cancer (UICC) of intrahepatic cholangiocarcinoma (ICC).

Methods: A total of 103 ICC patients who underwent hepatectomy between 2002 and 2016 were enrolled. The survival impact of AJCC/UICC 8th edition was examined. Read More

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http://dx.doi.org/10.1007/s11605-019-04185-1DOI Listing

Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex.

Chromosome Res 2019 Apr 23. Epub 2019 Apr 23.

Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.

Canine histiocytic malignancies (HM) are rare across the general dog population, but overrepresented in certain breeds, such as Bernese mountain dog and flat-coated retriever. Accurate diagnosis relies on immunohistochemical staining to rule out histologically similar cancers with different prognoses and treatment strategies (e.g. Read More

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http://dx.doi.org/10.1007/s10577-019-09606-0DOI Listing

Regional Differences in the Treatment of Localized Prostate Cancer: An Analysis of Surgery and Radiation Utilization in the United States.

Adv Radiat Oncol 2019 Apr-Jun;4(2):331-336. Epub 2019 Jan 23.

Department of Radiation Oncology, Weill Cornell Medical College and NewYork-Presbyterian Hospital, New York, New York.

Purpose: Men with localized prostate cancer have various treatment options available in their management. The optimal approach is controversial and can be influenced by multiple factors. This study aimed to investigate the influence of geographic region on the selection of treatment for prostate cancer. Read More

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http://dx.doi.org/10.1016/j.adro.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460229PMC
January 2019

A Single-Institution Experience in the Preoperative Selection of DCIS Patients for IORT using the ASTRO Consensus Guidelines.

Adv Radiat Oncol 2019 Apr-Jun;4(2):253-260. Epub 2018 Nov 20.

Department of Radiation Oncology, New York Presbyterian Hospital, Columbia University Medical Center, New York, New York.

Purpose: Intraoperative radiation therapy (IORT) as a form of accelerated partial breast irradiation (APBI) is controversial given the limited evidence to support its efficacy. However, it remains an attractive option for low-risk patients with ductal carcinoma in situ (DCIS), who derive a small absolute benefit in local control with standard whole breast irradiation (WBI). We examine how the American Society for Therapeutic Radiation Oncology (ASTRO) APBI consensus guidelines (CG) may be applied to the preoperative selection of patients with DCIS for IORT and determine treatment outcomes by CG group. Read More

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http://dx.doi.org/10.1016/j.adro.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460097PMC
November 2018

Subtitling of culture-bound terms: strategies and quality assessment.

Heliyon 2019 Apr 13;5(4):e01411. Epub 2019 Apr 13.

English and Translation Section, Department of Foreign Languages, University of Nizwa, Birkat Al Mouz, Nizwa, Oman.

Subtitling, one of the under-researched topics in translation studies, is a challenging task faced by many restrictions that compel subtitlers to use specific strategies to enhance the quality of the subtitles. In relation to this, this study aimed to identify the subtitling strategies adopted in subtitling the culture-bound terms in the American movie entitled 'The American Pie', and to assess the quality of the translation of these terms. For this purpose, the data was collected from the movie and qualitatively analyzed using Pedersen's (2005, 2011) typology and Pedersen's (2017) quality assessment model. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462774PMC

Ciprofloxacin infusion versus third generation cephalosporin as a surgical prophylaxis for percutaneous nephrolithotomy: a randomized study.

Cent European J Urol 2019 14;72(1):57-61. Epub 2019 Jan 14.

Menoufia University, Faculty of Medicine, Department of Urology, Shbeen el Kom, Egypt.

Introduction: Percutaneous nephrolithotomy (PCNL) is considered a clean-contaminated surgical procedure. The American Urological Association has recommended different preoperative antimicrobial prophylaxis for various urological procedures to prevent surgical site infections, postoperative fever, and possible sepsis. The European Association of Urology (EAU) antibiotic guidelines endorse giving either a second or third-generation cephalosporin, trimethoprim-sulfamethoxazole, fluoroquinolone or aminopenicillin with a β-lactamase inhibitor. Read More

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http://dx.doi.org/10.5173/ceju.2019.1698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469015PMC
January 2019

Diagnostic and Treatment Implications of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis.

Gastroenterol Hepatol (N Y) 2019 Feb;15(2):83-89

Dr Terrence Wong is a resident physician in the Department of Medicine in the Division of Gastroenterology and Hepatology at Alameda Health System-Highland Hospital in Oakland, California.

Nonalcoholic fatty liver disease (NAFLD) affects 75 to 100 million adults in the United States and is the leading cause of chronic liver disease worldwide, fueled by the rising epidemic of obesity and metabolic syndrome. NAFLD is the hepatic manifestation of metabolic syndrome; thus, accurately assessing and managing comorbid metabolic syndrome components is paramount. Nonalcoholic steatohepatitis (NASH) is a subset of NAFLD that includes a more progressive and advanced form of the disease, with a greater risk of fibrosis progression. Read More

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February 2019
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Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial.

Nat Med 2019 Apr 22. Epub 2019 Apr 22.

Worldwide Innovative Network (WIN) Association-WIN Consortium, Villejuif, France.

Precision medicine focuses on DNA abnormalities, but not all tumors have tractable genomic alterations. The WINTHER trial ( NCT01856296 ) navigated patients to therapy on the basis of fresh biopsy-derived DNA sequencing (arm A; 236 gene panel) or RNA expression (arm B; comparing tumor to normal). The clinical management committee (investigators from five countries) recommended therapies, prioritizing genomic matches; physicians determined the therapy given. Read More

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http://dx.doi.org/10.1038/s41591-019-0424-4DOI Listing

Status of Hypertension in Tehran: Potential impact of the ACC/AHA 2017 and JNC7 Guidelines, 2012-2015.

Sci Rep 2019 Apr 23;9(1):6382. Epub 2019 Apr 23.

Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

This study aimed to determine the prevalence of hypertension, the recommended anti-hypertensive therapy and the percentage of hypertensive patients who had achieved the blood pressure (BP) target according to 2017 American College of Cardiology/American Heart Association (ACC/AHA) versus JNC7 and 8 guidelines, among Iranian population. Data of participants aged ≥20 years from the fifth phase (2012-2015) of the Tehran lipid and glucose study (N = 10,576) were analyzed, using survey analysis. The weighted prevalence of hypertension among those not on anti-hypertensive medications was 42. Read More

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http://www.nature.com/articles/s41598-019-42809-3
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http://dx.doi.org/10.1038/s41598-019-42809-3DOI Listing
April 2019
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Oral health of cystic fibrosis patients at a north american center: A pilot study.

Med Oral Patol Oral Cir Bucal 2019 Apr 23. Epub 2019 Apr 23.

415 E Vine Str #304 Milwaukee, WI 53212

Background: The objective of this study was to describe the oral health status of Cystic Fibrosis (CF) children in a US facility.

Material And Methods: Twenty CF children ages 6-18 were recruited from Children's Hospital of Wisconsin Pulmonary Clinic. Parents completed a health questionnaire. Read More

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http://dx.doi.org/10.4317/medoral.22756DOI Listing

Point of Care Quantitative Assessment of Muscle Health in Older Individuals: An Investigation of Quantitative Muscle Ultrasound and Electrical Impedance Myography Techniques.

Geriatrics (Basel) 2018 Dec 16;3(4). Epub 2018 Dec 16.

Duke University Department of Orthopaedic Surgery, Durham, NC 27710, USA.

Muscle health is recognized for its critical role in the functionality and well-being of older adults. Readily accessible, reliable, and inexpensive methods of measuring muscle health are needed to advance research and clinical care. In this prospective, blinded study, 27 patients underwent quantitative muscle ultrasound (QMUS), standard electrical impedance myography (sEIM), and handheld electrical impedance myography (hEIM) of the anterior thigh musculature by two independent examiners. Read More

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http://dx.doi.org/10.3390/geriatrics3040092DOI Listing
December 2018

The Role of Age and Multimorbidity in Shaping Older African American Men's Experiences with Patient⁻Provider Communication.

Geriatrics (Basel) 2018 Oct 24;3(4). Epub 2018 Oct 24.

College of Human Medicine, Michigan State University, Flint, MI 48502, USA.

This study investigated factors associated with older African American men's unmet health communication needs in the context of patient-provider interactions. Responses to a health survey were analyzed for 430 African American men attending a Midwest community health fair. The outcome measure was the extent to which men could get their health-related questions answered during recent medical visits. Read More

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http://dx.doi.org/10.3390/geriatrics3040074DOI Listing
October 2018

Investigating the Enduring Impact of a Community-Based Health Education Program to Promote African American Elders' Use of Technology Designed to Support Chronic Disease Self-Management.

Geriatrics (Basel) 2018 Oct 13;3(4). Epub 2018 Oct 13.

School of Communication and Information, Rutgers University, New Brunswick, NJ 08901, USA.

Elders experience chronic disease disparities and barriers to access technology designed to support recommended self-management behaviors. Elders from racial minority groups are among those who experience particular disparities in chronic disease incidence, outcomes, and barriers to technology use. In order to investigate strategies to address barriers, the study team recruited elder African Americans with diabetes and young adults connected to the elders through naturally occurring familial or social networks. Read More

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http://dx.doi.org/10.3390/geriatrics3040070DOI Listing
October 2018

Chronic Kidney Disease and Older African American Adults: How Embodiment Influences Self-Management.

Geriatrics (Basel) 2018 Aug 16;3(3). Epub 2018 Aug 16.

Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA.

Patients living with chronic kidney disease (CKD) must balance the medical management of their kidney disease and other chronic conditions with their daily lives, including managing the emotional and psychosocial consequences of living with a chronic disease. Self-management is critical to managing chronic kidney disease, as treatment consists of a complex regimen of medications, dosages, and treatments. This is a particularly important issue for older African American adults who will comprise a significant portion of the older adult population in the coming years. Read More

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http://dx.doi.org/10.3390/geriatrics3030052DOI Listing

Older African American Men's Perspectives on Factors That Influence Type 2 Diabetes Self-Management and Peer-Led Interventions.

Geriatrics (Basel) 2018 Jul 6;3(3). Epub 2018 Jul 6.

School of Medicine, Wayne State University, Detroit, MI 48202, USA.

Older African American men are at increased risk of Type 2 Diabetes (T2D) but demonstrate high rates of poor illness management. They also participate in interventions targeting illness management at extremely low rates and are at high risk for dropout from clinical trials. One modifiable factor that has been identified in the literature that contributes to these disparities is health beliefs particular to men. Read More

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http://dx.doi.org/10.3390/geriatrics3030038DOI Listing

Organizational Readiness to Implement the Chronic Disease Self-Management Program in Dialysis Facilities.

Geriatrics (Basel) 2018 Jun 14;3(2). Epub 2018 Jun 14.

Emory University, School of Medicine, Atlanta, GA 30322, USA.

A gap exists between the development and uptake of evidence-based health promotion programs in health care settings. One reason for this gap is lack of attention to organizational readiness. The objective of this study was to assess organizational readiness to implement the Chronic Disease Self-Management Program in dialysis facilities. Read More

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http://dx.doi.org/10.3390/geriatrics3020031DOI Listing

Driving Decisions: Distinguishing Evaluations, Providers and Outcomes.

Geriatrics (Basel) 2018 May 11;3(2). Epub 2018 May 11.

Department of Medicine and Neurology, Washington University, St. Louis, MO 63110, USA.

Driving is a highly valued instrumental activity of daily living on which many older adults depend for access to their community. The demand to address driving is changing as older adults experience increasing longevity while facing medical conditions that often affect their fitness to drive. As one of the most complex of daily tasks, driving is a multifaceted issue that involves the older driver, family members, state licensing and health care practitioners. Read More

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http://dx.doi.org/10.3390/geriatrics3020025DOI Listing

Osteoporosis, Activities of Daily Living Skills, Quality of Life, and Dietary Adequacy of Congregate Meal Participants.

Geriatrics (Basel) 2018 May 10;3(2). Epub 2018 May 10.

Department of Physical Therapy, Florida International University, Miami, FL 33199, USA.

Osteoporosis, a chronic disease that results in low bone mass with an increased risk of fragility fractures, is prevalent in older adults. Diet can prevent or lessen the severity of osteoporosis. The purpose of this cross-sectional study was to assess differences in diet, quality of life, self-rated health, and physical function between congregate meal participants with and without osteoporosis. Read More

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http://dx.doi.org/10.3390/geriatrics3020024DOI Listing

Genetic Regulation of enoyl-CoA hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans.

Diabetes 2019 Apr 22. Epub 2019 Apr 22.

Department of Internal Medicine, Section of Endocrinology and Metabolism, Wake Forest School of Medicine, Winston-Salem, NC 27157

Insulin resistance (IR) is a harbinger of type 2 diabetes (T2D) and partly determined by genetic factors. However, genetically-regulated mechanisms of IR remain poorly understood. Using gene expression, genotype, and insulin sensitivity data from an African American cohort (AAGMEx), we performed transcript-wide correlation and expression quantitative trait loci (eQTL) analyses to identify IR-correlated -regulated transcripts (-eGenes) in adipose tissue. Read More

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http://dx.doi.org/10.2337/db18-1229DOI Listing

A pair of native fungal pathogens drives decline of a new invasive herbivore.

Proc Natl Acad Sci U S A 2019 Apr 22. Epub 2019 Apr 22.

Department of Entomology, Cornell University, Ithaca, NY 14853-2601.

Two North American fungal pathogens caused a coepizootic leading to localized collapse of an outbreak population of the newly invasive planthopper pest, the spotted lanternfly (), in the eastern United States. The pathogens partitioned the habitat, with the majority of on tree trunks killed by , while cadavers of killed by were usually on the ground. The future will show whether these pathogens will be drivers in boom-bust cycles or will result in recurrent low population densities of this new invasive species. Read More

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http://dx.doi.org/10.1073/pnas.1903579116DOI Listing
April 2019
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Health Supervision for Children With Neurofibromatosis Type 1.

Pediatrics 2019 Apr 22. Epub 2019 Apr 22.

Neurofibromatosis type 1 (NF1) is a multisystem disorder that primarily involves the skin and peripheral nervous system. Its population prevalence is approximately 1 in 3000. The condition is usually recognized in early childhood, when pigmentary manifestations emerge. Read More

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http://dx.doi.org/10.1542/peds.2019-0660DOI Listing

Ancestry patterns inferred from massive RNAseq data.

RNA 2019 Apr 22. Epub 2019 Apr 22.

GenPoB Research Group, of the Instituto de Investigación Sanitaria de Santiago (IDIS);

There is a growing body of evidence suggesting that patterns of gene expression vary within and between human populations. However, the impact of this variation in human diseases has been poorly explored, in part owing to the lack of a standardized protocol to estimate biogeographical ancestry from gene expression studies. Here we examine several studies that provide new solid evidence indicating that the ancestral background of individuals impacts gene expression patterns. Read More

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http://dx.doi.org/10.1261/rna.070052.118DOI Listing

Nonmodular Stems Are a Viable Alternative to Modular Stems in Revision Total Hip Arthroplasty.

J Arthroplasty 2019 Mar 19. Epub 2019 Mar 19.

Department of Orthopaedic Surgery, NYU Langone Medical Center, NYU Langone Orthopedic Hospital, New York, NY.

Background: Nonmodular and modular femoral stems have been associated with complications after revision total hip arthroplasty (rTHA). As such, the ideal femoral component for rTHA remains undecided. This study aims to report outcomes of titanium, tapered-fluted, modular and nonmodular femoral components in rTHA. Read More

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http://dx.doi.org/10.1016/j.arth.2019.03.007DOI Listing

PROMIS physical function underperforms psychometrically relative to American Shoulder and Elbow Surgeons score in patients undergoing anatomic total shoulder arthroplasty.

J Shoulder Elbow Surg 2019 Apr 19. Epub 2019 Apr 19.

Sports Medicine and Shoulder Service, Hospital for Special Surgery, New York, NY, USA.

Background: The purpose of this study was to evaluate the psychometric properties of the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function computer adaptive test (PF-CAT) relative to the American Shoulder and Elbow Surgeons (ASES) score in patients with glenohumeral osteoarthritis undergoing primary anatomic total shoulder arthroplasty (TSA).

Methods: A retrospective study of an institutional TSA registry was performed. Preoperative PROMIS PF-CAT and ASES scores were collected. Read More

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http://dx.doi.org/10.1016/j.jse.2019.02.011DOI Listing