186 results match your criteria American journal of cardiovascular disease[Journal]


Ethiopian university students' knowledge and perception towards cardiovascular disease risk factors: a cross sectional study.

Am J Cardiovasc Dis 2019 15;9(1):1-7. Epub 2019 Feb 15.

Department of Pharmaceutics, School of Pharmacy, College of Medicine & Health Sciences, University of Gondar P.O. Box 196, Gondar, Ethiopia.

Cardiovascular disease (CVD) is the commonest cause of morbidity and mortality with an estimation of 17.9 million deaths worldwide annually. Knowledge about the disease and risk factors changes individuals' health attitudes, behaviors and lifestyle practices. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420697PMC
February 2019
5 Reads

Electrocardiographic subclinical myocardial injury and alcohol consumption: a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey.

Am J Cardiovasc Dis 2018 15;8(5):58-65. Epub 2018 Dec 15.

Department of Internal Medicine, Section on Cardiology, School of Medicine, Wake Forest Winston Salem, NC, USA.

Background: Cardiac Infarction/Injury Score (CIIS), an electrocardiographic based scoring system, is a surrogate marker of subclinical myocardial injury (SC-MI) and has shown excellent prognostic value in predicting future cardiovascular mortality. As an association of mild to moderate alcohol consumption with cardiovascular disease (CVD) is conflicting, using an electrocardiographic based scoring system such as CIIS is a simple and cost-effective way to investigate this controversial relationship.

Methods: This analysis included 6090 participants (58. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334197PMC
December 2018
2 Reads

Prediction of mortality in patients with implantable defibrillator using CHADS2 score: data from a prospective observational investigation.

Am J Cardiovasc Dis 2018 15;8(5):48-57. Epub 2018 Dec 15.

Division of Cardiology, Department of Medicine, Azienda Ospedaliera Universitaria Integrata Verona, University of Verona Verona, Italy.

Background: CHADS2 (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, previous stroke/TIA) score has been validated as a risk stratification score to predict stroke in patients with atrial fibrillation (AF). The objective of this analysis was to assess whether patient risk factors, in particular CHADS2 score, identified patients at risk of mortality.

Methods: 821 patients with an implantable cardioverter defibrillator were prospectively followed-up in 11 cardiology centers. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334196PMC
December 2018
5 Reads

Is symptom to balloon time a better predictor of outcomes in acute ST-segment elevation myocardial infarction than door to balloon time?

Am J Cardiovasc Dis 2018 15;8(4):43-47. Epub 2018 Oct 15.

Providence Hospital and Medical Centers/Michigan State University Southfield, Michigan.

Introduction: Current guidelines for the treatment of ST-segment elevation myocardial infarction (STEMI) recommend early revascularization with a door-to-balloon (D2B) time of 90 minutes or less in patients undergoing primary percutaneous coronary intervention (PPCI). The focus of most studies has been D2B time. Because of the large variability in the time between symptom onset and presentation, we sought to determine the effect of symptom-to-balloon (S2B) time on presentation and outcomes as a potentially more clinically relevant parameter. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261836PMC
October 2018

Third-degree atrioventricular block followed by syncope, labile hypertension, and orthostatic hypotension in a patient with nasopharyngeal cancer: baroreflex failure.

Am J Cardiovasc Dis 2018 15;8(3):39-42. Epub 2018 Jun 15.

West Virginia University Heart and Vascular Institute Morgantown, WV, USA.

Baroreflex failure is a rare cause of syncope and labile blood pressures. Here, we present a case of baroreflex failure in a patient with history of nasopharyngeal cancer, status-post neck radiation. A 76-year-old male presented from an outside facility for possible pacemaker placement as he was found to have symptomatic third-degree atrioventricular (AV) block. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055071PMC
June 2018
31 Reads

Methylsulfonylmethane decreases inflammatory response to tumor necrosis factor-α in cardiac cells.

Authors:
Lindsey E Miller

Am J Cardiovasc Dis 2018 15;8(3):31-38. Epub 2018 Jun 15.

Department of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University USA.

The development of various cardiovascular diseases (CVDs) are associated with chronic inflammation. Tumor necrosis factor α (TNF-α) is a pro-inflammatory cytokine that activates the nuclear factor-κB (NF-κB) signaling pathway, leading to increased inflammatory cytokine expression, such as interleukin-6 (IL-6). Interventions to reduce each of these factors have been demonstrated to reduce the development of CVD. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055070PMC
June 2018
5 Reads

Application of animal and human PET in cardiac research.

Am J Cardiovasc Dis 2018 15;8(3):24-30. Epub 2018 Jun 15.

Department of Anesthesiology and Pain Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, PR China.

Purpose Of Review: After a warm-up period of imaging research, several modalities of positron emission tomography (PET) are under development for evaluating ischemic heart disease.

Recent Findings: Several types of well-documented stem/progenitor PET imaging have been utilized for changes in myocardial blood flow and carbohydrate metabolism. Some recent experimental and human studies reported that these data may have beneficial effects on cardiac research. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055072PMC
June 2018
1 Read

Chagasic cardiomyopathy and Pompe disease: case report.

Am J Cardiovasc Dis 2018 5;8(2):19-23. Epub 2018 Apr 5.

Hospital das Clínicas da UFPE, Department of Cardiology Brazil.

Background: Pompe disease is a lysosomal storage disease with an autosomal recessive inheritance characterized by an insufficient activity of the acid alpha-glucosidase enzyme. The incidence varies from 1:40000 to 1:200000 live births and cardiac involvement in adults is rare. Chagas disease is an infection caused by the protozoan Trypanosoma cruzi, in which one-third of the cases progress to the chronic form, and may lead to cardiac involvement, usually from the fifth decade of life onwards. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944812PMC
April 2018
8 Reads

Vitamin D deficiency and degree of coronary artery luminal stenosis in women undergoing coronary angiography: a prospective observational study.

Am J Cardiovasc Dis 2018 5;8(2):14-18. Epub 2018 Apr 5.

Department of Cardiovascular Medicine, Allegheny Health Network Pittsburgh, PA.

Background And Aims: Low serum 25-OH D levels are associated with increased cardiovascular morbidity and mortality. Recent studies have linked 25-OH D deficiency with the presence of CAD. Women, especially post-menopausal, tend to suffer from accelerated atherosclerosis, along with vitamin D deficiency. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944811PMC
April 2018
1 Read

Circulating microRNA profiles in different arterial territories of stable atherosclerotic disease: a systematic review.

Am J Cardiovasc Dis 2018 5;8(1):1-13. Epub 2018 Feb 5.

Department of Cardiology, Hospital de Santa Marta, Centro Hospitalar de Lisboa CentralLisbon, Portugal.

Aims: Atherosclerosis is associated with altered circulating microRNA profiles. It is yet unclear whether the expression of these potential biomarkers differs according to the location of atherosclerosis. We assessed whether atherosclerosis of different arterial territories, except the coronary, is associated with specific circulating microRNA profiles. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840275PMC
February 2018
4 Reads

Systemic inhibition of neddylation by 3-day MLN4924 treatment regime does not impair autophagic flux in mouse hearts and brains.

Am J Cardiovasc Dis 2017 20;7(6):134-150. Epub 2017 Dec 20.

Division of Basic Biomedical Science, Sanford School of Medicine of The University of South DakotaSD 57069, USA.

Beyond helping the cell survive from energy starvation via self-eating a portion of cytoplasm, macroautophagy is also capable of targeted removal of defective organelles or cytoplasmic aberrant protein aggregates, thereby playing an important role in quality control in the cell. Impaired or suppressed macroautophagy activity is associated with the progression from a large subset of heart diseases to heart failure and with the development of the vast majority of, if not all, neurodegenerative diseases, the leading causes of death and disability in humans. Hence, a better understanding of the impact of existing and upcoming pharmacotherapies on macroautophagy in the heart and brain will undoubtedly benefit the search for safer and more effective treatment to improve human health. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768871PMC
December 2017

Associations between four types of single-nucleotide polymorphisms in PLA2G7 gene and clinical atherosclerosis: a meta-analysis.

Am J Cardiovasc Dis 2017 20;7(6):122-133. Epub 2017 Dec 20.

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Syiah Kuala UniversityAceh, Indonesia.

Background: Previous studies suggested that some types of single nucleotide polymorphisms (SNPs) in PLA2G7 genes, encoding Lp-PLA2 have been reported to yield an antiatherogenic effect, but other studies mentioned otherwise. Thus, a comprehensive study to explore the effect of SNPs in PLA2G7 genes (V279F, A379V, R92H, I198T) toward clinical atherosclerosis is needed.

Methods: We searched eligible studies from PubMed, EBSCO, ProQuest, Science Direct, Springer, and Cochrane databases for case-control studies to assess the between four types of SNPs in PLA2G7 gene with risk of clinical atherosclerosis (CVD = cardiovascular disease, CAD = coronary artery disease, PAD = peripheral artery disease, ischemic stroke). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768870PMC
December 2017
3 Reads

Galectin-3 and the incidence of abdominal aortic aneurysm: the atherosclerosis risk in communities (ARIC) study.

Am J Cardiovasc Dis 2017 20;7(6):114-121. Epub 2017 Dec 20.

Division of Epidemiology & Community Health, School of Public Health, University of MinnesotaMinneapolis, Minnesota, USA.

Galectin-3, a β-galactosidase binding lectin, known to be involved in inflammatory processes may be associated with abdominal aortic aneurysm (AAA) incidence. We examined the prospective association between plasma galectin-3 and incident AAA in 9,704 participants of the Atherosclerosis Risk in Communities (ARIC) study cohort. We followed participants from 1996-1998 through 2011 (124,260 person-years) for incident AAA (n=325) defined by ICD codes from hospital records and death certificates. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768869PMC
December 2017
5 Reads

Ejection fraction improvement and reverse remodeling achieved with Sacubitril/Valsartan in heart failure with reduced ejection fraction patients.

Am J Cardiovasc Dis 2017 20;7(6):108-113. Epub 2017 Dec 20.

Division of Cardiology, University of Ottawa Heart InstituteOttawa, Ontario, Canada.

Background: Sacubitril/Valsartan has been shown to improve mortality and reduce hospitalizations in patients with heart failure with reduced ejection fraction (HFrEF). The effect of Sacubitril/Valsartan on ejection fraction (EF) and reverse remodeling parameters have not been previously described.

Methods: We performed a single-center, retrospective, cohort study of HFrEF patients (n=48) who were treated with Sacubitril/Valsartan for a median duration of 3 months (Interquartile range 2-6 months). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768868PMC
December 2017
12 Reads

Gender differences in ST-elevation myocardial infarction (STEMI) time delays: experience of a public health service in Salvador-Brazil.

Am J Cardiovasc Dis 2017 1;7(5):102-107. Epub 2017 Nov 1.

Specialist in Cardiology/Brazilian Society of CardiologySalvador - BA, 41180-780, Brazil.

Background: Delays in attending to ST-elevation myocardial infarction (STEMI) are indicators or markers of quality of health services. Several records suggest gender disparity in cardiac care as a contributor to the increased mortality among women.

Methods: We prospectively enrolled all consecutive STEMI patients who were transferred to our hospital from January through December 2015. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698564PMC
November 2017
7 Reads

Off label use of direct oral anticoagulants for left ventricular thrombus. Is it appropriate?

Am J Cardiovasc Dis 2017 1;7(5):98-101. Epub 2017 Nov 1.

Department of Cardiology, Providence Hospital and Medical Centers/Michigan State UniversitySouthfield, Michigan, USA.

A 57 year old gentleman with a history of non-ischemic cardiomyopathy and paroxysmal atrial fibrillation presented with worsening lower extremity edema and dyspnea on exertion. He had been compliant with his medications including rivaroxaban (Xarelto) for atrial fibrillation that he takes with the evening meal daily. His echocardiogram showed an ejection fraction of 10-15% and a new left ventricle (LV) apical thrombus. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698563PMC
November 2017
2 Reads

Effects of intensive pitavastatin therapy on glucose control in patients with non-ST elevation acute coronary syndrome.

Am J Cardiovasc Dis 2017 25;7(4):89-96. Epub 2017 Jul 25.

The Second Hospital of Hebei Medical UniversityShijiazhuang 050000, China.

This study aimed to investigate the effects of intensive pitavastatin therapy on glucose control in patients with non-ST elevation acute coronary syndrome (ACS). Patients who had ACS with significant stenosis on initial coronary angiography and received successful percutaneous coronary intervention (PCI) in the Second Hospital of Hebei Medical University, Shijiazhuang, China from August 2015 to January 2016 were enrolled in this study. The patients were randomized to receive pitavastatin (4 mg daily) or atorvastatin (20 mg daily). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545210PMC
July 2017
47 Reads

Direct evidence of sympathetic hyperactivity in patients with vasospastic angina.

Am J Cardiovasc Dis 2017 15;7(3):83-88. Epub 2017 Jun 15.

Department of Cardiology, University Hospital of RangueilToulouse, France.

Background: The autonomic nervous system is reported to be involved in the pathogenesis of vasospastic angina (VSA). Studies based on heart rate variability analysis have shown conflicting results with both a reduction and an enhancement of sympathetic nervous system (SNS) activity in patients with Prinzmetal's variant angina, but direct assessment has never been performed. The aim of our study was to evaluate the SNS activity using microneurography in patients with VSA. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498819PMC
June 2017
23 Reads

Aging is protective against pressure overload cardiomyopathy via adaptive extracellular matrix remodeling.

Am J Cardiovasc Dis 2017 15;7(3):72-82. Epub 2017 Jun 15.

Department of Medicine, Division of Cardiology, University of California San FranciscoSan Francisco, CA, USA.

When challenged by hemodynamic stress, aging hearts respond differently to young hearts. Preclinical models of heart disease should take into account the effects of age. However, in the transverse aortic constriction (TAC) model of pressure-overload cardiomyopathy, the larger aorta of aging mice has not previously been taken into account. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498818PMC
June 2017
17 Reads

Metabolic parameters and responsiveness of isolated iliac artery in LDLr mice: role of aerobic exercise training.

Am J Cardiovasc Dis 2017 15;7(2):64-71. Epub 2017 Apr 15.

School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, SPBrazil.

Physical inactivity and dyslipidemia are considered risk factors for cardiovascular diseases. There are few studies evaluating the effects of physical exercise in small-caliber artery in a model that mimics familial hypercholesterolemia. The aim of this study was to examine the effect of exercise training, at moderate intensity, on metabolic parameters and iliac artery responsiveness in LDL mice. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435607PMC
April 2017
8 Reads

Altered expression of and in a rat model of Adriamycin-induced chronic heart failure.

Am J Cardiovasc Dis 2017 15;7(2):57-63. Epub 2017 Apr 15.

Henan Key Laboratory of Tissue Regeneration, Xinxiang Medical UniversityXinxiang 453003, Henan, P. R. China.

A small number of cardiac stem cells that express the c-Kit and Nanog biomarkers can be differentiated into myocardial cells, which suggests that these stem cells may be able to repair damage and provide an internal reserve for tissue regeneration. It is unknown, however, whether the levels of myocardial stem cells are altered after heart failure (HF), and whether HF affects the myocardial regenerative ability. In this study, to address this question, we developed a rat model of chronic HF induced by Adriamycin, and examined the morphological changes in c-Kit and Nanog-expressing stem cells in heart tissue of normal and HF rats. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435606PMC
April 2017
11 Reads

Early-onset Lyme carditis with concurrent disseminated erythema migrans.

Am J Cardiovasc Dis 2017 15;7(2):53-56. Epub 2017 Apr 15.

West Virginia University Heart and Vascular InstituteMorgantown, WV, USA.

Background: Lyme disease is an infection that is estimated to affect over 300,000 people in the United States annually. Typically, it presents with erythema migrans (EM), an annular rash at the site of tick attachment, within 3 to 30 days of inoculation. Untreated patients may progress to early disseminated disease. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435605PMC
April 2017
42 Reads

Does ischemic burden on stress testing influence patient survival in subjects with known severe multi-vessel CAD?

Am J Cardiovasc Dis 2017 15;7(2):48-52. Epub 2017 Apr 15.

Montefiore Medical Center/Albert Einstein College of MedicineBronx, NY, USA.

Background: Ischemic burden observed during stress testing has been postulated to predict prognosis irrespective of anatomic atherosclerotic burden observed on angiography. However, it is not known if the stress test result influences the long-term prognosis of subjects with diffuse coronary artery disease. We sought to determine the prognostic importance of stress test false negativity amongst patients with severe multi-vessel coronary artery disease (CAD) undergoing stress testing in the previous decade. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435604PMC
April 2017
21 Reads

Leucine-nicotinic acid synergy stimulates AMPK/Sirt1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia and atherosclerosis in mice.

Am J Cardiovasc Dis 2017 15;7(2):33-47. Epub 2017 Apr 15.

NuSirt Biopharma Inc.Knoxville, TN, USA.

Background/aims: Nicotinic acid (NA), a lipid-lowering drug, serves as a source of NAD, the cofactor for Sirt1. Leucine (Leu) stimulates the AMPK/Sirt1 axis and amplifies the effects of other AMPK/Sirt1 activating compounds. Therefore, we tested the interactive effects of leucine and low dose NA on AMPK/Sirt1 signaling and downstream effects of lipid metabolism in cell culture, C. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435603PMC
April 2017
31 Reads

Antioxidant and anti-inflammatory medicinal plants have potential role in the treatment of cardiovascular disease: a review.

Am J Cardiovasc Dis 2017 15;7(2):19-32. Epub 2017 Apr 15.

Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of TechnologyOgbomoso, Oyo State Nigeria.

Cardiovascular disease is a compound name for clusters of disorders afflicting the heart and blood vessels; it is assuming an increasing role as a major cause of morbidity and mortality. Unhealthy practices such as smoking, high intake of saturated fat and cholesterol, diabetes and physical inactivity are predisposing factors. The risk factors cause alteration in vascular integrity, compromised membrane integrity, increase free radical generation and reduced endogenous antioxidant system resulting in oxidative stress. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435602PMC
April 2017
32 Reads

Long-term clinical outcomes of patients with rheumatoid arthritis and concomitant coronary artery disease.

Am J Cardiovasc Dis 2017 15;7(1):9-18. Epub 2017 Feb 15.

Department of Cardiovascular, San Raffaele Scientific Institute Milan, Italy.

Background: Rheumatoid arthritis (RA) is associated with high morbidity and mortality predominately due to increased cardiovascular risk. Few reports are available regarding the management of coronary artery disease (CAD) in RA patients and the long-term clinical outcomes after coronary revascularization.

Methods And Results: All consecutive patients with RA were identified by retrospective review at a rheumatology tertiary center in Milan, Italy between 2001 and 2013. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344967PMC
February 2017
19 Reads

Comparison of ticagrelor and high-dose clopidogrel on the platelet functions in patients with inadequate response to clopidogrel.

Am J Cardiovasc Dis 2017 15;7(1):1-8. Epub 2017 Feb 15.

Department of Cardiology, The Second Hospital of Hebei Medical University Shijiazhuang 050000, China.

Objective: To evaluate the effects of ticagrelor and high-dose clopidogrel on the platelet functions in patients with inadequate response to clopidogrel.

Methods: In this prospective, randomized and controlled study, patients who had been diagnosed as acute coronary syndrome (ACS) with inadequate response to clopidogrel in the Second Hospital of Hebei Medical University from July 2015 to June 2016 were enrolled. Inadequate response to clopidogrel was defined as absolute reduction of platelet aggregation rate (PAR) <30% or PAR >70%. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344966PMC
February 2017
14 Reads

Tsutsugamushi disease presenting with aortic valve endocarditis: a case report and literature review.

Am J Cardiovasc Dis 2016 30;6(4):185-190. Epub 2016 Nov 30.

Department of Cardiology, The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630, China; Institute Integrated Traditional Chinese and Western Medicine, Sun Yat-sen UniversityGuangzhou 510630, China.

Tsutsugamushi disease is a zoonotic disease caused by in which humans are accidental hosts. Infective endocarditis associated with Tsutsugamushi disease has not been previously reported. We are describing a case of Tsutsugamushi disease presenting with aortic valve endocarditis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218851PMC
November 2016
14 Reads

Relationship between R-R interval and left ventricular systolic synchrony in subjects with coronary artery disease determined using angiography.

Am J Cardiovasc Dis 2016 30;6(4):175-184. Epub 2016 Nov 30.

Department of Echocardiography, First Affiliated Hospital, Xinjiang Medical University Urmuqi, China.

The aim of this study was to assess the relationship between R-R interval and left ventricular systolic synchrony in subjects with coronary artery disease determined using angiography. A total of 277 subjects who underwent coronary angiography for suspected CAD were recruited in this study. For all subjects, the R-R interval was quantified using simultaneous ECG, and the times to peak systolic longitudinal strain (Tssl) on 17 LV segments were quantified using four-dimensional (4D) speckle tracking echocardiography (STE) and manually measured. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218850PMC
November 2016
1 Read

Generation of a giant coronary artery aneurysm from an intra-plaque cavity with a ruptured fibrous cap: an observation over time through coronary angiography.

Am J Cardiovasc Dis 2016 30;6(4):171-174. Epub 2016 Nov 30.

Division of Cardiology, Hiratsuka City Hospital Hiratsuka, Kanagawa, Japan (Drs Takagi, Inohara, Kusumoto, Matsubara).

A 74-year-old man underwent coronary artery bypass graft surgery. Thirteen years later, he presented with complaints of exertional anterior chest oppression again. Computed tomography coronary angiography revealed the significant stenosis at the mid right coronary artery (RCA). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218849PMC
November 2016
1 Read

The function of cathepsins B, D, and X in atherosclerosis.

Am J Cardiovasc Dis 2016 30;6(4):163-170. Epub 2016 Nov 30.

Section on Cardiovascular Medicine, Wake Forest School of Medicine Winston Salem, NC.

Cathepsins are proteolytic enzymes typically located within the lysosomes of macrophages. Once released, they can enhance the inflammatory process in atherosclerosis. Cathepsin X aids in the migration of T-lymphocytes and the release of cytokines. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218848PMC
November 2016
5 Reads

Effects of sitagliptin on coronary atherosclerosis in patients with type 2 diabetes-A serial integrated backscatter-intravascular ultrasound study.

Am J Cardiovasc Dis 2016 30;6(4):153-162. Epub 2016 Nov 30.

Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital Yokohama, Japan.

Dipeptidyl peptidase-4 (DPP-4) inhibitors have demonstrated anti-inflammatory and anti-atherogenic effects in an animal model. However, the clinical usefulness of DPP-4 inhibitors, particularly its effects on coronary atherosclerosis, has not been evaluated thus far. Therefore, in this study, we evaluated the effects of sitagliptin, a DPP-4 inhibitor, on coronary atherosclerosis using integrated backscatter (IB)-intravascular ultrasound (IVUS) in patients with type 2 diabetes. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218847PMC
November 2016
13 Reads

Influence of different doses of coffee on post-exercise blood pressure response.

Am J Cardiovasc Dis 2016 30;6(4):146-152. Epub 2016 Nov 30.

Laboratory of Physical Training Study Applied to Performance and Health, Department of Physical Education, Federal University of Paraíba João Pessoa, Brazil.

The reduction in blood pressure after the physical exercise practice is called postexercise hypotension (PEH). Previous studies have demonstrated that the ingestion of caffeine at levels corresponding to three doses of coffee eliminates this phenomenon. Thus, we evaluated the influence of different doses of coffee in the PEH in twelve hypertensives, who performed four experimental sessions of aerobic exercise on a cycle ergometer (lasting 40 minutes, with intensity between 60% and 80% of maximum heart rate), followed by the ingestion of one (CAF-1), two (CAF-2), or three (CAF-3) doses of caffeinated coffee, or three doses of decaffeinated coffee (DESC). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218846PMC
November 2016
6 Reads

Screening of in Malay patients with ventricular septal defect.

Am J Cardiovasc Dis 2016 30;6(4):138-145. Epub 2016 Nov 30.

Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia 16150 Kubang Kerian, Kelantan, Malaysia.

Ventricular septal defect (VSD) is the most common form of cardiac malformations accounting approximately 20% of all congenital heart defects. is an inhibitory protein that antagonizes the signalling of TGF-β family member and has been found in the development and function of mouse heart models. This study aims to screen and identify the polymorphisms of exonic regions in Malay population with VSD. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218845PMC
November 2016
3 Reads

Diabetic indicators are the strongest predictors for cardiovascular disease risk in African American adults.

Am J Cardiovasc Dis 2016 15;6(3):129-37. Epub 2016 Sep 15.

Department of Nutrition, Food and Exercise Sciences, Florida State UniversityTallahassee, Florida, USA; Institute for Successful Longevity Affiliate, Florida State UniversityTallahassee, Florida, USA.

African Americans have higher risk of developing type 2 diabetes and cardiovascular disease (CVD) compared to other racial groups. Modifiable and non-modifiable factors play a role in the development of both diseases. This study assessed diabetes indicators in relation to other CVD risk factors taking into account confounders, among African American adults. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030392PMC
September 2016
1 Read

Angiotensin type 2-receptor (AT2R) activation induces hypotension in apolipoprotein E-deficient mice by activating peroxisome proliferator-activated receptor-γ.

Am J Cardiovasc Dis 2016 15;6(3):118-28. Epub 2016 Sep 15.

Division of Cardiology, Department of Medicine, Emory University Atlanta, Georgia, USA.

Angiotensin II (Ang II) modulates blood pressure and atherosclerosis development through its vascular type-1 (AT1R) and type-2 (AT2R) receptors, which have opposing effects. AT2R activation produces hypotension, and is anti-atherogenic. Targeted overexpression of AT2Rs in vascular smooth muscle cells (VSMCs) indicates that these effects are due to increased nitric oxide (NO) generation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030391PMC
September 2016
1 Read

Documentation of various approaches and outcomes in patients on warfarin undergoing dental procedures: a review article.

Am J Cardiovasc Dis 2016 15;6(3):109-17. Epub 2016 Sep 15.

King Fahad Cardiac Center, Department of Cardiac Sciences, College of Medicine, King Saud University Riyadh, Saudi Arabia.

Appropriate management of patients with mechanical prosthetic valves on warfarin during dental procedures is crucial. If the patients continue warfarin, they might develop bleeding, while interruption of therapy can cause thromboembolic events. Bridging therapy (mostly heparin) is used in some patients, while others stop medications. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030390PMC
September 2016
4 Reads

Critical role of mitochondrial ROS is dependent on their site of production on the electron transport chain in ischemic heart.

Am J Cardiovasc Dis 2016 15;6(3):93-108. Epub 2016 Sep 15.

Department of Physiology, School of Medicine, University of Texas Health Science Center at San Antonio TX, USA.

Reactive oxygen species (ROS) generation has been implicated in many pathologies including ischemia/reperfusion (I/R) injury. This led to multiple studies on antioxidant therapies to treat cardiovascular diseases but paradoxically, results have so far been mixed as ROS production can be beneficial as a signaling mechanism and in cardiac protection via preconditioning interventions. We investigated whether the differential impact of increased ROS in injury as well as in protection could be explained by their site of production on the mitochondrial electron transport chain. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030389PMC
September 2016
10 Reads

Myocardial energetics and the role of micronutrients in heart failure: a critical review.

Am J Cardiovasc Dis 2016 15;6(3):81-92. Epub 2016 Sep 15.

Dr. Rath Research Institute Santa Clara, CA 95050, USA.

Heart failure is a multifactorial disease with poor prognosis. There are many hypotheses regarding the cause of heart failure. Leading among them are the hemodynamic and the neuro-hormonal hypotheses. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030388PMC
September 2016
1 Read

Small mammalian animal models of heart disease.

Am J Cardiovasc Dis 2016 15;6(3):70-80. Epub 2016 Sep 15.

Department of Biomedical Sciences and Pathobiology, Center for Veterinary Regenerative Medicine, College of Veterinary Medicine, Virginia Polytechnic Institute and State University Blacksburg, VA, 24061, USA.

There is an urgent clinical need to develop new therapeutic approaches for treating cardiovascular disease, but the biology of cardiovascular regeneration is complex. Model systems are required to advance our understanding of the pathogenesis, progression, and mechanisms underlying cardiovascular disease as well as to test therapeutic approaches to regenerate tissue and restore cardiac function following injury. An ideal model system should be inexpensive, easily manipulated, reproducible, physiologically representative of human disease, and ethically sound. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030387PMC
September 2016
4 Reads

Does smoking increase the risk of progression of nephropathy and/or cardiovascular disease in type 2 diabetic patients with albuminuria and those without albuminuria?

Am J Cardiovasc Dis 2016 18;6(2):66-9. Epub 2016 May 18.

Department of Medical Emergency, Ibn Sina University Hospital10000, Rabat, Morocco; Laboratory of Biostatistics, Clinical and Epidemiological Research, Medical School University Mohamed VRabat, Morocco.

Unlabelled: Diabetic nephropathy is the primary cause of chronic kidney disease and is associated with increased cardiovascular mortality. Cigarette smoking is probably the most complex and the least understood among the risk factors for chronic kidney disease and cardiovascular disease in diabetic patients. The aim of this study was to determine the impact of smoking on progression of nephropathy and cardiovascular disease in type 2 diabetic patients with albuminuria and those without albuminuria. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913216PMC
June 2016
1 Read

Arrhythmogenic Right Ventricular Cardiomyopathy - 4 Swedish families with an associated PKP2 c.2146-1G>C variant.

Am J Cardiovasc Dis 2016 18;6(2):55-65. Epub 2016 May 18.

Department of Clinical Pathology and Clinical Genetics, and Department of Clinical Experimental Medicine, Linköping University Linköping, Sweden.

In this study, the genotype-phenotype correlations in four unrelated families with a PKP2 c.2146-1G>C gene variant were studied. Our primary aim was to determine the carriers that fulfilled the arrhythmogenic right ventricular cardiomyopathy (ARVC) diagnostic criteria of 2010. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913215PMC
June 2016
2 Reads

Increased expression of estrogen-related receptor β during adaptation of adult cardiomyocytes to sustained hypoxia.

Am J Cardiovasc Dis 2016 18;6(2):46-54. Epub 2016 May 18.

Gazes Cardiac Research Institute, Department of Medicine, Medical University of South CarolinaCharleston, South Carolina, USA; Ralph H. Johnson Department of Veterans Affairs Medical CenterCharleston, South Carolina, USA.

Unlabelled: Estrogen-related Receptors (ERR) are members of the steroid hormone receptor superfamily of transcription factors that regulate expression of genes required for energy metabolism including mitochondrial biogenesis, fatty acid oxidation and oxidative phosphorylation. While ERRα and EPPγ isoforms are known to share a wide array of target genes in the adult myocardium, the function of ERRβ has not been characterized in cardiomyocytes. The purpose of this study was to determine the role of ERRβ in regulating energy metabolism in adult cardiomyocytes in primary culture. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913214PMC
June 2016
5 Reads

Hemodynamic and metabolic response during dynamic and resistance exercise in different intensities: a cross-sectional study on implications of intensity on safety and symptoms in patients with coronary disease.

Am J Cardiovasc Dis 2016 18;6(2):36-45. Epub 2016 May 18.

Cardiopulmonary Physical Therapy LaboratoryBrazil; Department of BioengineeringUSP, Brazil.

Resistance (RE) and aerobic exercise (AE) can promote hemodynamic, physiologic and clinical modifications in coronary artery disease (CAD) patients. The aim of the study is to assess key physiologic and clinical responses during RE at 30% and 60% of 1-RM on a 45° leg press and to compare responses during AE. We evaluated fifteen male subjects with coronary artery disease (60. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913213PMC
June 2016
13 Reads

Inhibition of collagen synthesis by select calcium and sodium channel blockers can be mitigated by ascorbic acid and ascorbyl palmitate.

Am J Cardiovasc Dis 2016 18;6(2):26-35. Epub 2016 May 18.

Dr. Rath Research Institute Santa Clara, CA 95050, USA.

Calcium, sodium and potassium channel blockers are widely prescribed medications for a variety of health problems, most frequently for cardiac arrhythmias, hypertension, angina pectoris and other disorders. However, chronic application of channel blockers is associated with numerous side effects, including worsening cardiac pathology. For example, nifedipine, a calcium-channel blocker was found to be associated with increased mortality and increased risk for myocardial infarction. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913212PMC
June 2016
18 Reads

Long non-coding RNA-mediated regulation of glucose homeostasis and diabetes.

Am J Cardiovasc Dis 2016 18;6(2):17-25. Epub 2016 May 18.

Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School Boston, MA 02115, USA.

Long non-coding RNAs (lncRNAs) represent an important class of non-coding RNAs that plays key roles in regulating the expression of genes in health and disease. Accumulating genetic, experimental, and epidemiological studies highlight a growing list of lncRNAs that control glucose homeostasis and diabetic pathologies and complications. Through interactions with chromatin, RNA, and protein, lncRNAs modulate chromatin modification, mRNA stability, microRNA activity, and the function of proteins such as transcription factors. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913211PMC
June 2016
1 Read

Ventricular septal rupture complicating acute myocardial infarction in the modern era with mechanical circulatory support: a single center observational study.

Am J Cardiovasc Dis 2016 1;6(1):10-6. Epub 2016 Mar 1.

Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine Bronx, NY, USA.

Ventricular septal rupture (VSR) is a rare but devastating complication after acute myocardial infarction (AMI). While the incidence has decreased, the mortality rate from VSR has remained extremely high. The use of mechanical circulatory support with intra-aortic balloon pump (IABP) and extracorporal membrane oxygenation (ECMO) may be useful in providing hemodynamic stability and time for myocardial scarring. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788724PMC
April 2016
37 Reads

High fat diet induced alterations of atrial electrical activities in mice.

Am J Cardiovasc Dis 2016 1;6(1):1-9. Epub 2016 Mar 1.

Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota Vermillion, SD 57069, USA.

Obesity is a well-known risk factor for various cardiovascular diseases. Recent clinical data showed that overweight and obese patients have higher incidence of atrial fibrillation (AF) compared with individuals with normal body weights, but the underlying mechanisms remain to be elucidated. In this study, we investigated the effects of a high fat diet on atrial activities in mice. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788723PMC
April 2016
4 Reads

The influence of type 2 diabetes and gender on ventricular repolarization dispersion in patients with sub-clinic left ventricular diastolic dysfunction.

Am J Cardiovasc Dis 2015 12;5(4):155-66. Epub 2015 Oct 12.

Department of Internal Medicine Faculty of Medicine Tetovo, Republic of Macedonia.

Objective: To assess the influence of type 2 DM and gender, on the QT dispersion, Tpeak-Tend dispersion of ventricular repolarization, in patients with sub-clinic left ventricular diastolic dysfunction of the heart.

Background: QT dispersion, that reflects spatial inhomogeneity in ventricular repolarization, Tpeak-Tend dispersion, this on the other hand reflects transmural inhomogeneity in ventricular repolarization, that is increased in an early stage of cardiomyopathy, and in patients with left ventricular diastolic dysfunction, as well. The left ventricular diastolic dysfunction, a basic characteristic of diabetic heart disease (diabetic cardiomyopathy), that developes earlier than systolic dysfunction, suggests that diastolic markers might be sensitive for early cardiac injury. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620119PMC
November 2015
7 Reads