1,503 results match your criteria American journal of cancer research[Journal]


Volasertib suppresses the growth of human hepatocellular carcinoma and [Retraction].

Authors:

Am J Cancer Res 2020 1;10(5):1630. Epub 2020 May 1.

[This retracts the article on p. 2476 in vol. 6, PMID: 27904765. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269776PMC

MLL5α activates AR/NDRG1 signaling to suppress prostate cancer progression.

Am J Cancer Res 2020 1;10(5):1608-1629. Epub 2020 May 1.

Department of Urology, Beijing Chaoyang Hospital, Capital Medical University Beijing 100020, China.

Prostate cancer (PCa) is one of the most prevalent malignancies in men. However, the molecular mechanism controlling the transformation of androgen-dependent PCa (ADPC) to castration-resistant PCa (CRPC) is largely unknown. Androgen receptor (AR) signaling has been reported to play a key role in this process; thus, searching for the novel AR co-activator is important for identifying the mechanism underlying PCa progression. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269778PMC

Examining factors underlying geographic disparities in early-onset colorectal cancer survival among men in the United States.

Am J Cancer Res 2020 1;10(5):1592-1607. Epub 2020 May 1.

Vanderbilt University Medical Center 2525 West End Ave., Nashville, Tennessee, USA.

Despite overall incidence reduction in colorectal cancer (CRC) the past 32 years, unexplained incidence and mortality rates have increased significantly in younger adults ages 20-49. To improve understanding of sex-specific differences among this population, we aimed to determine the variance in early-onset CRC (EOCRC) survival among US men diagnosed with CRC before age 50, while considering individual- and county-level CRC outcome determinants. Hotspots (i. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269786PMC

Breast cancer in low-middle income countries: abnormality in splicing and lack of targeted treatment options.

Am J Cancer Res 2020 1;10(5):1568-1591. Epub 2020 May 1.

SA-MRC/UP Precision Prevention & Novel Drug Targets for HIV-Associated Cancers (PPNDTHAC) Extramural Unit, Pan African Cancer Research Institute (PACRI), University of Pretoria, Faculty of Health Sciences Hatfield, 0028, South Africa.

Breast cancer is a common malignancy among women worldwide. Regardless of the economic status of a country, breast cancer poses a burden in prevention, diagnosis and treatment. Developed countries such as the U. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269781PMC

has prognostic value in colorectal cancer and represses Warburg effect and cell proliferation via Wnt signaling.

Am J Cancer Res 2020 1;10(5):1548-1567. Epub 2020 May 1.

Department of Medical Oncology, Zhongshan Hospital of Fudan University NO. 180, Fenglin Road, Xuhui District, Shanghai 200032, China.

Colorectal cancer (CRC) is a common malignant tumor worldwide. The solute carrier family 25 member 18 (SLC25A18) transports glutamate across the inner mitochondrial membrane and involves some non-tumor diseases, yet little is known about its role in malignancy. Here, we studied the function and mechanism of SLC25A18 in CRC. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269784PMC

Identification of a transcriptomic signature with excellent survival prediction for squamous cell carcinoma of the cervix.

Am J Cancer Res 2020 1;10(5):1534-1547. Epub 2020 May 1.

Center for Biotechnology and Genomic Medicine, Medical College of Georgia at Augusta University Augusta, GA, USA.

Survival for patients with newly diagnosed cervical cancer has not significantly improved over the past several decades. We sought to identify a clinically relevant set of prognostic genes for squamous cell carcinoma of the cervix (SCCC), the most common cervical cancer subtype. Using RNA-sequencing data and survival data from 203 patients in The Cancer Genome Atlas (TCGA), we conducted a series of analyses using different decile cutoffs for gene expression to identify genes that could indicate large and consistent survival differences across different decile cutoffs of gene expression. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269782PMC
May 2020
3.968 Impact Factor

Current statuses of molecular targeted and immune checkpoint therapies in hepatocellular carcinoma.

Am J Cancer Res 2020 1;10(5):1522-1533. Epub 2020 May 1.

Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University Hangzhou, People's Republic of China.

Treatment of advanced hepatocellular carcinoma (HCC) still confronts great challenges due to high rate of therapeutic resistance. The emergence of systemic treatment with molecular targeted and immune checkpoint therapies has brought novel approaches towards patients with advanced HCC. However, sorafenib, as the first approved systemic treatment in 2007, only increased overall survival by three months in advanced HCC patients. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269783PMC

Should patients stop their radiotherapy or chemotherapy during the COVID-19 pandemic.

Am J Cancer Res 2020 1;10(5):1518-1521. Epub 2020 May 1.

Department of Thoracic Cardiovascular Surgery, General Hospital of Central Theater Command of The People's Liberation Army Wuhan, China.

In the previous stage, there were too many patients with Corona virus disease 2019 (COVID-19) in Wuhan. Ordinary people, patients, even doctors, had a great sense of desperate. On the one hand, almost all doctors participated in the treatment of patients of COVID-19. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269792PMC

Incidence and prognosis of liver metastasis at diagnosis: a pan-cancer population-based study.

Am J Cancer Res 2020 1;10(5):1477-1517. Epub 2020 May 1.

KU Leuven, Campus Gasthuisberg, Faculty of Medicine Leuven 3000, Belgium.

Metastasis is a major cause of cancer-related death and liver metastasis (LM) is a distinct type for its relatively good prognosis after timely treatment for selected patients. However, a generalizable estimation of incidence and prognosis of LM is lacking. Cancer patients with known LM status in the Surveillance, Epidemiology and End Results database were enrolled in the present study. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269791PMC

Preventive effect of celecoxib in sorafenib-related hand-foot syndrome in hepatocellular carcinoma patients, a single-center, open-label, randomized, controlled clinical phase III trial.

Am J Cancer Res 2020 1;10(5):1467-1476. Epub 2020 May 1.

Department of Liver Surgery, Sun Yat-sen University Cancer Center Guangzhou, P. R. China.

Skin toxicity, especially hand-foot syndrome (HFS), is one of the most common sorafenib-induced adverse events (AEs) in hepatocellular carcinoma (HCC) patients, leading to treatment interruption and failure. Mucocutaneous inflammation may cause HFS; therefore, we investigated whether celecoxib can alleviate HFS, improve patients' quality of life and increase survival when administered in conjunction with active therapy. Our randomized, open-label study prospectively enrolled 116 advanced HCC patients receiving sorafenib as targeted therapy from July 2015 to July 2016. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269790PMC

BAP1 maintains chromosome stability by stabilizing DIDO1 in renal cell carcinoma.

Am J Cancer Res 2020 1;10(5):1455-1466. Epub 2020 May 1.

Department of Urology, Zhongnan Hospital of Wuhan University Wuhan, China.

BRCA1-associated protein 1 (BAP1) is a member of the ubiquitin C-terminal hydrolase family of deubiquitinating enzymes and is implicated in transcriptional regulation. The gene is mutated in 5%-15% of patients with clear cell renal cell carcinoma (ccRCC), the most common form of renal cancer, which suggests that BAP1 is a tumor suppressor. However, whether BAP1 influences the progression of ccRCC tumors expressing wildtype (WT) BAP1 is unclear. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269789PMC

NQO1 is a determinant for cellular sensitivity to anti-tumor agent Napabucasin.

Am J Cancer Res 2020 1;10(5):1442-1454. Epub 2020 May 1.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics Beijing 102206, China.

Napabucasin (NAPA) is thought to be a potent cancer stemness inhibitor in different types of cancer cell lines. While it has shown promising activity in early phase clinical trials, two recent phase III NAPA clinical trials failed to meet the primary endpoint of overall survival. The reason for the failure is not clear, but a possible way to revive the clinical trial is to stratify patients with biomarkers that could predict NAPA response. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269777PMC

Combined effects of mesenchymal stem cells carrying cytosine deaminase gene with 5-fluorocytosine and temozolomide in orthotopic glioma model.

Am J Cancer Res 2020 1;10(5):1429-1441. Epub 2020 May 1.

Department of Anatomy, Ajou University School of Medicine Suwon, South Korea.

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor, and current standard therapy provides modest improvements in progression-free and overall survival of patients. Innate tumor resistance and presence of the blood-brain barrier (BBB) require the development of multi-modal therapeutic regimens. Previously, cytosine deaminase (CD)-expressing mesenchymal stem cells (MSC/CD) were found to exhibit anticancer activity with a wide therapeutic index by converting 5-fluorocytosine (5-FC), a nontoxic prodrug into 5-fluorouracil (5-FU), a potent anticancer drug. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269785PMC

Aberrant USP11 expression regulates NF90 to promote proliferation and metastasis in hepatocellular carcinoma.

Am J Cancer Res 2020 1;10(5):1416-1428. Epub 2020 May 1.

Department of Pathology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430079, China.

Growing evidence indicates that deubiquitinase ubiquitin-specific protease 11 (USP11) plays an important role in cellular function by regulating the stability of its substrates. USP11 is dysregulated in many types of cancer and involved in tumor development and progression. We previously showed that USP11 was upregulated in hepatocellular carcinoma (HCC) and promoted HCC cell invasion and metastasis potency. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269773PMC

CLIC4 regulates radioresistance of nasopharyngeal carcinoma by iNOS after γ-rays but not carbon ions irradiation.

Am J Cancer Res 2020 1;10(5):1400-1415. Epub 2020 May 1.

Institute of Radiation Medicine, Shanghai Medical College, Fudan University Shanghai, China.

Nasopharyngeal carcinoma (NPC) is a major health problem in the East and Southeast Asia, and the intensity modulated radiotherapy (IMRT) is the current preferred treatment method of NPC, but radioresistance-induced residual and recurrent tumors are the main cause of treatment failure. Till now, the mechanism of radioresistance and prognostic biomarkers of NPC are still unrevealed. In this study, we collected clinical NPC samples and established radioresistant NPC-R cell lines by irradiating NPC cells with fractionation doses of γ-rays. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269788PMC

Inhibiting ULK1 kinase decreases autophagy and cell viability in high-grade serous ovarian cancer spheroids.

Am J Cancer Res 2020 1;10(5):1384-1399. Epub 2020 May 1.

The Mary & John Knight Translational Ovarian Cancer Research Unit, London Regional Cancer Program London, Ontario, Canada.

Metastasis in high-grade serous ovarian cancer (HGSOC) occurs through an unconventional route that involves exfoliation of cancer cells from primary tumors and peritoneal dissemination via multicellular clusters or spheroids. Previously, we demonstrated autophagy induction in HGSOC spheroids grown and in spheroids collected from ovarian cancer patient ascites; thus, we speculate that autophagy may contribute to spheroid cell survival and overall disease progression. Hence, in this study we sought to evaluate whether ULK1 (unc-51-like kinase-1), a serine-threonine kinase critical for stress-induced autophagy, is important for autophagy regulation in HGSOC spheroids. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269771PMC

Overexpression of COX7RP promotes tumor growth and metastasis by inducing ROS production in hepatocellular carcinoma cells.

Am J Cancer Res 2020 1;10(5):1366-1383. Epub 2020 May 1.

National-Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, Second Affiliated Hospital, Xi'an Jiaotong University Xi'an, Shaanxi, People's Republic of China.

Cumulative evidence has indicated that mitochondrial respiration dysfunction plays important roles in tumorigenesis. However, the role of COX7RP, a critical regulator in the formation of mitochondrial respiratory supercomplex that has been suggested to be over-expressed in hepatocellular carcinoma (HCC) by our bioinformatic analysis of TCGA data, in tumor progression remains largely unclear. In this study, we found that COX7RP is frequently over-expressed in HCC mainly due to the down-regulation of miR-130a-3p and predicts poor prognosis of HCC patients. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269779PMC

A novel, small peptide with activity against human pancreatic cancer.

Am J Cancer Res 2020 1;10(5):1356-1365. Epub 2020 May 1.

Kalos Therapeutics Incorporated Phoenix, Arizona, United States of America.

KTH-222 is a novel, 8-amino acid length peptide. It is derived from a motif identified in a group of peptides that are related to atrial natriuretic peptide and that are able to inhibit cancer cell growth. We report here that KTH-222 inhibits the attachment, proliferation, and development of an invasive morphology in cultured human pancreatic tumor cells (MIA PaCa-2 and HPAC). Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269787PMC

Predicting long-term multicategory cause of death in patients with prostate cancer: random forest versus multinomial model.

Am J Cancer Res 2020 1;10(5):1344-1355. Epub 2020 May 1.

Department of Pathology, Princeton Medical Center Plainsboro, NJ, USA.

The majority of patients with prostate cancer die of non-cancer causes of death (COD). It is thus important to accurately predict multi-category COD in these patients. Random forest (RF), a popular machine learning model, has been shown useful for predicting binary cancer-specific deaths. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269775PMC
May 2020
3.968 Impact Factor

Prolactin and androgen R1881 induce pro-survival carboxypeptidase-D and EDD E3 ligase in triple-negative and HER2+ breast cancer.

Am J Cancer Res 2020 1;10(5):1321-1343. Epub 2020 May 1.

Department of Biochemistry & Molecular Biology, Faculty of Medicine, Dalhousie University Halifax, NS, Canada.

Plasma membrane carboxypeptidase-D (CPD) hydrolyzes C-terminal arginine (Arg) from extracellular substrates, and Arg is converted into nitric oxide (NO) in the cell. CPD is upregulated by prolactin (PRL) and androgens in breast cancer (BCa) cells, increasing NO production to promote cell survival. EDD E3 ubiquitin ligase, upregulated by PRL/androgens, is implicated in TORC1 signaling. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269772PMC

Immune battle at the premalignant stage of colorectal cancer: focus on immune cell compositions, functions and cytokine products.

Authors:
Guanglin Cui

Am J Cancer Res 2020 1;10(5):1308-1320. Epub 2020 May 1.

Research Group of Gastrointestinal Diseases, The Second Affiliated Hospital of Zhengzhou University Zhengzhou, China.

It is now widely accepted that most human cancers, including colorectal cancers (CRCs), develop from premalignant lesions through a long-term multistep process. Host immunity is a key determinant that maintains most premalignant lesions in a stable state via immunosurveillance. However, premalignant cells use diverse strategies to escape host immunosurveillance. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269793PMC

Chronic stress-induced immune dysregulation in cancer: implications for initiation, progression, metastasis, and treatment.

Am J Cancer Res 2020 1;10(5):1294-1307. Epub 2020 May 1.

Department of Breast Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine Hangzhou 310009, P. R. China.

Psychological stress is a well-accepted risk factor in cancer initiation and progression. The explosive growth of psychoneuroimmunology research in the past decade has yielded an unprecedented wealth of information about the critical role of chronic stress in the immune dysfunction that influences tumor behaviors, which presents insights to mitigate distress and improve prognosis in cancer patients. Chronic stress exacerbates inflammation and causes a metabolism disorder, making it difficult for the organisms to maintain homeostasis and increasing its susceptibility to cancer. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269780PMC

The role of mitochondrial dynamics in human cancers.

Am J Cancer Res 2020 1;10(5):1278-1293. Epub 2020 May 1.

Department of Ophthalmology, Ninth People's Hospital of Shanghai, Shanghai Jiao Tong University School of Medicine Shanghai, China.

Mitochondria are crucial cellular organelles. Under extracellular stimulations, mitochondria undergo constant fusion and fission dynamics to meet different cellular demands. Mitochondrial dynamics is regulated by specialized proteins and lipids. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269774PMC

Erratum: Angiopoietin-like 4 deficiency upregulates macrophage function through the dysregulation of cell-intrinsic fatty acid metabolism.

Am J Cancer Res 2020 1;10(4):1277. Epub 2020 Apr 1.

Department of Immunology, School of Medicine, Yangzhou University Yangzhou 225001, P. R. China.

[This corrects the article on p. 595 in vol. 10, PMID: 32195030. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191092PMC
April 2020
3.968 Impact Factor

Erratum: PTTG promotes invasion in human breast cancer cell line by upregulating EMMPRIN via FAK/Akt/mTOR signaling.

Am J Cancer Res 2020 1;10(4):1274-1276. Epub 2020 Apr 1.

Qingdao University Qingdao 266071, Shandong, China.

[This corrects the article on p. 425 in vol. 6, PMID: 27186413. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191105PMC
April 2020
3.968 Impact Factor

Erratum: Hispidulin prevents hypoxia-induced epithelial-mesenchymal transition in human colon carcinoma cells.

Am J Cancer Res 2020 1;10(4):1271-1273. Epub 2020 Apr 1.

Medical College, Qingdao University Qingdao 266071, Shandong, China.

[This corrects the article on p. 1047 in vol. 5, PMID: 26045985. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191100PMC
April 2020
3.968 Impact Factor

Interferon regulatory factor-1 suppresses DNA damage response and reverses chemotherapy resistance by downregulating the expression of RAD51 in gastric cancer.

Am J Cancer Res 2020 1;10(4):1255-1270. Epub 2020 Apr 1.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430022, Hubei, P. R. China.

Recent studies have shown that IRF-1 plays a significant role in various tumour-induced chemoresistance, but its role and mechanism in gastric cancer-associated chemoresistance are not clear. Our study showed that IRF-1 expression could reverse gastric cancer-related chemoresistance. Dysregulated DNA repair is an important cause of chemoresistance. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191096PMC

SH3BGRL2 exerts a dual function in breast cancer growth and metastasis and is regulated by TGF-β1.

Am J Cancer Res 2020 1;10(4):1238-1254. Epub 2020 Apr 1.

Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University Shanghai 200032, China.

SH3 domain-binding glutamic acid-rich-like protein 2 (SH3BGRL2) is a poorly defined member of the SH3BGR gene family with potential roles in cell differentiation and tissue development. Here, we report for the first time that SH3BGRL2 exerts a dual function in breast tumor growth and metastasis. SH3BGRL2 was downregulated in a subset of primary breast tumors, and suppressed breast cancer cell proliferation and colony formation and xenograft tumor growth . Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191107PMC

Cisplatin sensitivity mediated by NKX2-1 in lung adenocarcinoma is dependent on p53 mutational status via modulating TNFSF10 expression.

Am J Cancer Res 2020 1;10(4):1229-1237. Epub 2020 Apr 1.

Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University Taipei, Taiwan.

NKX2-1 was shown to enhance cisplatin sensitivity in KRAS-mutated cells, but it conferred cisplatin resistance in EGFR-mutated lung adenocarcinoma cells. However, NKX2-1 as a dual role in tumor progression depended on p53 mutational status via modulation of the NF-κB pathway. We hypothesized that NKX2-1 may confer cisplatin resistance in p53-mutated (p53-MT) lung adenocarcinoma cells but may enhance cisplatin sensitivity in wild-type (p53-WT) cells. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191106PMC

Pre-transplant cytoreductive therapy can improve overall survival of patients with MDS-AML but not MDS-EB2 receiving HLA-matched sibling donor peripheral blood stem cell transplantation.

Am J Cancer Res 2020 1;10(4):1218-1228. Epub 2020 Apr 1.

Institute of Hematology & Blood Diseases Hospital, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin, China.

To evaluate whether cytoreductive therapy is needed for myelodysplastic syndromes (MDS) patients with excess blasts type 2 (MDS-EB2) and acute myeloid leukemia derived from MDS (MDS-AML) before HLA-matched sibling donor peripheral blood stem cell transplantation (MSD-PBSCT), we retrospectively analyzed 80 cases of MDS-EB2 and MDS-AML patients who received MSD-PBSCT between February 2006 and December 2019 in our hospital. The 3-years overall survival (OS) rate and disease-free survival (DFS) rate were (59.1±5. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191098PMC
April 2020
3.968 Impact Factor

Verteporfin induced SUMOylation of YAP1 in endometrial cancer.

Am J Cancer Res 2020 1;10(4):1207-1217. Epub 2020 Apr 1.

Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital, Fudan University Shanghai, People's Republic of China.

Yes-associated protein (YAP or YAP1) has been proposed to function as an oncogene in most cancers, with nuclear localization of YAP1 correlating with poor prognosis. Photosensitizer Verteporfin has been proven as an inhibitor of YAP1 through preventing the combination of YAP1 with TEA domain transcription factor (TEAD). We showed previously that the total and phospho-levels of YAP1 were related to the clinical characteristics and outcomes in endometrial cancer (EC) patients, and that YAP1 promoted the proliferation and metastasis of EC cells in vitro cell line studies and in animal models. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191103PMC

Inhibition of CDK2 reduces EZH2 phosphorylation and reactivates ERα expression in high-grade serous ovarian carcinoma.

Am J Cancer Res 2020 1;10(4):1194-1206. Epub 2020 Apr 1.

Graduate Institute of Biomedical Sciences, Research Center for Cancer Biology, and Center for Molecular Medicine, China Medical University Taichung 404, Taiwan.

The cyclin-dependent kinase 2 (CDK2) inhibitor dinaciclib, a potential anti-cancer drug, has been tested in clinical trials and reported to suppress tumor initiating cells. Our recent study demonstrated that pharmacological inhibition of CDK2 or enhancer of zeste homolog 2 (EZH2) allows re-expression of ERα and converts triple-negative breast cancers (TNBC) to luminal ERα-positive, rendering TNBC cells targetable by tamoxifen. Like TNBC, EZH2 is also commonly overexpressed in ovarian cancers, and overexpression of cyclin E1 gene (CCNE1) and/or amplification of its associated kinase gene is present in ovarian tumor specimens, both of which are associated with primary treatment resistance and poor outcome in high-grade serous ovarian cancer (HGSC). Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191104PMC

Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells.

Am J Cancer Res 2020 1;10(4):1182-1193. Epub 2020 Apr 1.

Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center Shanghai, China.

ADP Ribosylation Factor 6 (ARF6) is a part of the RAS superfamily and regulates vesicular trafficking, remodeling of membrane lipids, and signaling pathways. Our previous study has found that ARF6, functioned as a downstream of Kras/ERK signaling pathway, could promote proliferation and Warburg effect in pancreatic cancer cells. Moreover, ARF6 is promising to be a biomarker for predicting prognosis of pancreatic cancer. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191101PMC

V3 ameliorates colitis-associated tumorigenesis by modulating the gut microbiome.

Am J Cancer Res 2020 1;10(4):1170-1181. Epub 2020 Apr 1.

Institute of Food Science and Technology, National Taiwan University Taipei 10617, Taiwan.

spp., a common probiotic used as a dietary supplement, is good for the digestive system. However, its anti-cancer activity still remains unclear. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191089PMC

USP18 deubiquitinates and stabilizes Twist1 to promote epithelial-mesenchymal transition in glioblastoma cells.

Am J Cancer Res 2020 1;10(4):1156-1169. Epub 2020 Apr 1.

Department of Neurosurgery, The 904th Hospital of People's Liberation Army (PLA), Clinical Medical College of Anhui Medical University Wuxi, Jiangsu, China.

Aberrant activation of epithelial-mesenchymal transition (EMT) pathway drives the invasion and migration of multiple cancers including glioblastoma (GBM). Clinical interventions focused on inhibiting EMT are of increasing interest in the treatment of GBM. In the present study, we discovered that glioma tissues and cells, especially GBMs show significantly up-modulated ubiquitin-specific protease 18 (USP18) expression. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191102PMC

CDK9 inhibitor CDKI-73 is synergetic lethal with PARP inhibitor olaparib in BRCA1 wide-type ovarian cancer.

Am J Cancer Res 2020 1;10(4):1140-1155. Epub 2020 Apr 1.

Department of Gynecology, Obstetrics & Gynecology Hospital, Fudan University Shanghai 200011, China.

Poly (adenosine diphosphate ribose) polymerase (PARP) inhibitors benefit a small percentage of ovarian cancer patients with homologous recombination (HR) deficiency (HRD), which greatly limits the applications of PARP inhibitors. Given the function of CDK9 in homologous recombination repair (HRR), here, we show how to extend the utility of PARP inhibitors in BRCA1-proficient ovarian cancer by targeting CDK9. We found that high CDK9 expression is associated with a higher tumor stage in epithelial ovarian cancer patients, and CDK9 is co-expressed with BRCA1 by analyzing a public database. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191097PMC
April 2020
3.968 Impact Factor

Circular RNA circEIF3I promotes papillary thyroid carcinoma progression through competitively binding to miR-149 and upregulating KIF2A expression.

Am J Cancer Res 2020 1;10(4):1130-1139. Epub 2020 Apr 1.

Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.

Circular RNAs (circRNAs) have been shown to regulate the development and progression of various cancers. However, the expression and function of circRNAs in papillary thyroid cancer (PTC) remain largely unknown. This study is aimed to investigate the potential roles of circEIF3I in PTC and elucidate the functional mechanism. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191093PMC

miR-216a-mediated upregulation of TSPAN1 contributes to pancreatic cancer progression via transcriptional regulation of ITGA2.

Am J Cancer Res 2020 1;10(4):1115-1129. Epub 2020 Apr 1.

College of Life Science and Bioengineering, Beijing University of Technology Beijing 100124, China.

Pancreatic cancer (PC) is recognized as the most aggressive and deadliest malignancy because it has the highest mortality of all cancers in humans. Mutations in multiple tumor suppressors and oncogenes have been documented to be involved in pancreatic cancer progression and metastasis. The upregulation of tetraspanin 1 (TSPAN1), a transmembrane protein, has been reportedly observed in many human cancers. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191091PMC

BRAF in malignant melanoma progression and metastasis: potentials and challenges.

Am J Cancer Res 2020 1;10(4):1103-1114. Epub 2020 Apr 1.

Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University Makkah, Saudi Arabia.

Recent advances in gene sequencing have shown that activated BRAF mutations are present in more than 50% of malignant melanomas and contribute to constitutive signals in the MAPK pathway. Besides the importance of its mutations in cell proliferation, BRAF is associated with lymph node, brain and liver metastasis, along with the loss of PTEN expression and ATG5. Knowledge of this genetic alteration has led to the development of personalized and targeted therapy strategies which block different pathways driving melanoma pathogenesis. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191094PMC
April 2020
3.968 Impact Factor

Heterogeneous responses in hepatocellular carcinoma: the achilles heel of immune checkpoint inhibitors.

Am J Cancer Res 2020 1;10(4):1085-1102. Epub 2020 Apr 1.

Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou 310003, China.

Treatment of patients with hepatocellular carcinoma (HCC) remains a serious challenge due to high heterogeneity and limited treatment options. In the past few decades, immune therapy, especially immune checkpoint therapy, has become an alternative option for the treatment of malignancies including HCC. Immune checkpoint inhibitors (ICIs) have raised attention because of their significant antitumor effect and low toxicity. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191099PMC

The roles and mechanisms of YTH domain-containing proteins in cancer development and progression.

Am J Cancer Res 2020 1;10(4):1068-1084. Epub 2020 Apr 1.

Holistic Integrative Pharmacy Institutes, School of Medicine, Hangzhou Normal University Hangzhou, Zhejiang, China.

Evolutionarily conserved YT521-B homology (YTH) domain-containing proteins, including YTHDF1-3 and YTHDC1-2, are known to confer mA-dependent RNA-binding activity. The YTH domain-containing proteins participate in numerous RNA processes, such as mRNA splicing, nuclear export, translation and decay in post-transcriptional regulation. Most recently, it has been found that YTH domain-containing proteins play important roles in post-transcriptional modification process hence modulate the expression of genes involved in cancer and other processes including cell cycle progression, cell proliferation, migration and invasion, inflammatory, immunity and autophagy. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191095PMC

The trastuzumab era: current and upcoming targeted HER2+ breast cancer therapies.

Am J Cancer Res 2020 1;10(4):1045-1067. Epub 2020 Apr 1.

Translation Oncology Laboratory, Avera Cancer Institute Sioux Falls, SD 57105, USA.

Human Epidermal Growth Factor Receptor 2-positive breast cancer (HER2+ BC) is defined by increased amplification of the oncogene and/or overexpression of its associated HER2 transmembrane receptor protein. HER2+ BC represents approximately 15-20% of breast cancer, and it is independently associated with a higher grade, more aggressive phenotype, and worse prognosis. With the advent of trastuzumab, the prognostic landscape for HER2+ BC patients has considerably improved. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191090PMC

LPPR4 promotes peritoneal metastasis via Sp1/integrin α/FAK signaling in gastric cancer.

Am J Cancer Res 2020 1;10(3):1026-1044. Epub 2020 Mar 1.

Department of Medical Oncology, The First Hospital of China Medical University Shenyang 110001, China.

Gastric cancer (GC) is one of the most common malignancies which has high incidence and mortality worldwide. Peritoneal dissemination is the main route of metastasis in advanced GC. However, few reliable diagnostic or prognostic biomarkers are available for peritoneal metastasis of GC. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136906PMC
March 2020
3.968 Impact Factor

METTL3 enhances cell adhesion through stabilizing integrin β1 mRNA via an m6A-HuR-dependent mechanism in prostatic carcinoma.

Am J Cancer Res 2020 1;10(3):1012-1025. Epub 2020 Mar 1.

Department of Urology, The First Affiliated Hospital of University of South China Hengyang, Hunan, China.

Bone metastasis is the major cause of morbidity and mortality in patients with prostate cancer (PCa). However, the underlying mechanism of bone-specific metastasis remain vague. Recently, with the deep research of N6-methyladenine (m6A) mRNA methylation, many studies directly focus on the role of m6A modification in human diseases, especially in cancers. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136910PMC

SMYD2 suppresses APC2 expression to activate the Wnt/β-catenin pathway and promotes epithelial-mesenchymal transition in colorectal cancer.

Am J Cancer Res 2020 1;10(3):997-1011. Epub 2020 Mar 1.

Department of General Surgery, Affiliated Hospital of Xuzhou Medical University Xuzhou 221000, China.

Cancer metastasis is a significant challenge in colorectal cancer (CRC) therapy. SET and MYND domain-containing protein 2 (SMYD2) is highly expressed in multiple cancers but is rarely studied in CRC. This study aims to identify whether abnormal expression of SMYD2 is associated with cancer metastasis in CRC. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136915PMC
March 2020
3.968 Impact Factor

Safety and effectiveness of apatinib in patients with previously treated metastatic gastric cancer: a sub-analysis from the real-world study of apatinib for gastric cancer treatment (AHEAD-G202).

Am J Cancer Res 2020 1;10(3):987-996. Epub 2020 Mar 1.

Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital Tianjin 300060, China.

Apatinib, a VEGFR2 receptor tyrosine kinase inhibitor, showed survival benefits in Asian patients with heavily pretreated advanced gastric cancer. However, the adverse event (AEs) profile of apatinib has limited its use. Dosing schedules are used to alleviate toxicities despite no supportive evidence. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136926PMC

The association and joint effect of serum cholesterol, glycemic status with the risk of incident cancer among middle-aged and elderly population in china cardiometabolic disease and cancer cohort (4C)-study.

Am J Cancer Res 2020 1;10(3):975-986. Epub 2020 Mar 1.

The State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine Shanghai, China.

The associations between different combinations of metabolic abnormalities and the risk of all and site-specific cancers remain unclear. We aimed to estimate the association and interplay between serum cholesterol, glycemic status and risk of cancer in the China Cardiometabolic Disease and Cancer Cohort (4C)-Study, a nationwide, multicenter, prospective, population-based study. The investigation was performed in 137,884 participants during 2014-2016. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136907PMC
March 2020
3.968 Impact Factor

MicroRNA-590-3p inhibits invasion and metastasis in triple-negative breast cancer by targeting Slug.

Am J Cancer Res 2020 1;10(3):965-974. Epub 2020 Mar 1.

Department of Breast Surgery, Harbin Medical University Cancer Hospital Harbin 150000, China.

miR-590-3p acts as a tumor suppressor in glioblastoma multiform, medulloblastoma, hepatocellular carcinoma, and nephroblastoma. Here, we studied the role of miR-590-3p in triple-negative breast cancer (TNBC). The miR-590-3p levels in TNBC specimens were significantly lower than those in non-TNBC specimens. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136920PMC

Neddylation inhibitor, MLN4924 suppresses angiogenesis in huvecs and solid cancers: and study.

Am J Cancer Res 2020 1;10(3):953-964. Epub 2020 Mar 1.

Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University Taipei 100, Taiwan.

Cullin-RING E3 ligases are involved in the ubiquitination of substrates that regulate important biological processes and are a potential therapeutic target in many types of cancer. MLN4924, a small molecule of NEDD8-activating enzyme inhibitor, inactivates CRL by blocking cullin neddylation and has been reported to elicit anti-tumor effect. In this study, In this study, we aimed to investigate the effects of MLN4924 on angiogenesis in human umbilical vascular endothelial cells (HUVECs) and four types of cancer cells. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136913PMC

Ligustrazine reverts anthracycline chemotherapy resistance of human breast cancer by inhibiting JAK2/STAT3 signaling and decreasing fibrinogen gamma chain (FGG) expression.

Am J Cancer Res 2020 1;10(3):939-952. Epub 2020 Mar 1.

Department of Oncology, 960 Hospital of PLA Jinan 250031, China.

Chemotherapy resistance is a major challenge for breast cancer treatment. It is necessary to elucidate the mechanisms of anthracycline resistance to develop new chemosensitizers for breast cancer. In this study, we explored the effects of ligustrazine (TMP) on reverting anthracycline resistance of breast cancer cells, as well as its related mechanisms. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136924PMC