120 results match your criteria American journal of blood research[Journal]


Partial pressure of oxygen in the human body: a general review.

Am J Blood Res 2019 15;9(1):1-14. Epub 2019 Feb 15.

Physiology Section, Department of Cell Biology, Physiology and Immunology, Universitat de Barcelona Barcelona, Spain.

The human body is a highly aerobic organism, in which it is necessary to match oxygen supply at tissue levels to the metabolic demands. Along metazoan evolution, an exquisite control developed because although oxygen is required as the final acceptor of electron respiratory chain, an excessive level could be potentially harmful. Understanding the role of the main factors affecting oxygen availability, such as the gradient of pressure of oxygen during normal conditions, and during hypoxia is an important point. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420699PMC
February 2019
4 Reads

Use of direct oral anticoagulants in daily practice.

Am J Blood Res 2018 10;8(4):57-72. Epub 2018 Dec 10.

College of Medicine, Al-Imam Mohammad Ibn Saud Islamic University Riyadh, Saudi Arabia.

In recent years, the options for anticoagulant therapy have examined new direct oral anticoagulants (DOACs) comprising direct thrombin inhibitors (dabigatran) and direct factor Xa inhibitors (rivaroxaban, apixaban, and edoxaban). These agents represent further progress towards the ideal anticoagulant drug and thus towards a safe and effective antithrombotic therapy. The ideal anticoagulant is oral and has a wide therapeutic range, predictable pharmacokinetics and pharmacodynamics, a rapid onset of action, an available antidote, minimal side effects, and minimal interactions with other drugs or food. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334188PMC
December 2018
7 Reads

Advances in biology of acute lymphoblastic leukemia (ALL) and therapeutic implications.

Am J Blood Res 2018 10;8(4):29-56. Epub 2018 Dec 10.

Department of Medicine, University of Alberta Edmonton, Alberta, Canada.

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer and also occurs in adults. Although the outcomes of multi-agent chemotherapy regimens have greatly improved, high toxicity and relapses in many patients necessitate the development of novel therapeutic approaches. Advances in molecular profiling and cytogenetics have identified a broad range of genetic abnormalities, including gene mutations, chromosome translocations and aneuploidy, which has provided a more comprehensive understanding of the biology and pathogenesis of ALL. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334189PMC
December 2018
5 Reads

Comparing serum levels of zinc, copper, certain antioxidant vitamins and dietary intakes in acute lymphoblastic leukemia (ALL) patients before and after chemotherapy.

Am J Blood Res 2018 5;8(3):21-28. Epub 2018 Oct 5.

Department of Nutrition, School of Public Health, Iran University of Medical Sciences Tehran, Iran.

Acute lymphoblastic leukemia (ALL) is a malignant hematologic disease. Cancer and its treatments can affect biological functions and change the nutritional status of patients. Zinc and copper are important cofactors for several enzymes and play an important role in maintaining the integrity of DNA. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261838PMC
October 2018
2 Reads

An isolated der(1;21)(q10;q10) translocation in a patient with myelodysplastic syndrome: a case report.

Am J Blood Res 2018 5;8(3):17-20. Epub 2018 Oct 5.

Osaka General Hospital of West Japan Railway Company 1-2-22 Matsuzaki-cho, Abeno-ku, Osaka 545-0053, Japan.

Whole-arm translocations are relatively rare among hematological malignancies. There are a few reports on myeloid malignancies harboring der(1;21)(q10;q10). A 65-year-old male was referred to our hospital due to squamous cell carcinoma of the lung. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261837PMC
October 2018
3 Reads

Comparison of DNA demethylating and histone deacetylase inhibitors hydralazine-valproate versus vorinostat-decitabine incutaneous t-cell lymphoma in HUT78 cells.

Am J Blood Res 2018 5;8(2):5-16. Epub 2018 Jun 5.

Unidad De Investigacion Biomédica En Cancer, Instituto De Investigaciones Biomédicas UNAM/Instituto Nacional De Cancerología México.

Purpose: Cutaneous T-cell lymphoma (CTCL) is an uncommon extranodal non-Hodgkin T-cell lymphoma that originates from mature T lymphocytes homed at the skin. Epigenetic alterations observed in CTCL are not limited to overexpression of Histone Deacetylases but also to DNA hypermethylation. The known synergy between Histone deacetylase inhibitors (HDACi) and DNA methyltransferases inhibitors (DNMTi) suggests that combining these agent classes could be effective for CTCL. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055069PMC
June 2018
11 Reads

Trisomy 6 as the sole stemline abnormality in a patient with acute monocytic leukemia: a case report.

Am J Blood Res 2018 5;8(1):1-4. Epub 2018 Apr 5.

Department of Hematology, Osaka General Hospital of West Japan Railway Company 1-2-22 Matsuzaki-cho, Abeno-ku, Osaka 545-0053, Japan.

It is rare for trisomy 6 to occur as the sole autosomal anomaly in hematological malignancies, but this finding has been reported to be associated with a hypoplastic bone marrow. We report the case of a 75-year-old male with acute monocytic leukemia, in which trisomy 6 was detected as the sole stemline abnormality. We also summarize the 26 published cases of acute myeloid leukemia involving isolated trisomy 6. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943614PMC

Evaluation of bone mineral density and related parameters in patients with haemophilia: a single center cross-sectional study.

Am J Blood Res 2017 1;7(5):59-66. Epub 2017 Nov 1.

Ege Adult Haemophilia Centre, Ege University HospitalIzmir, Turkey.

Haemophilia has been associated with low bone mineral density (BMD) probably due to some predisposing factors. The aim of this study was to evaluate the relationship between BMD and potential clinical predictors in adult haemophilic patients. Fortynine patients with moderate and severe haemophilia were enrolled. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698560PMC
November 2017
14 Reads

Cytogenetic study is not essential in patients with aplastic anemia.

Am J Blood Res 2017 1;7(5):49-58. Epub 2017 Nov 1.

Department of Genetics, Vivekananda Institute of Medical SciencesKolkata, India.

Depending on contemporary treatment approach of aggressive immunosuppression, Aplastic Anemia (AA) is caused by immunological destruction of otherwise normal hematopoietic stem cells. The aim was to summarize the cytogenetic abnormalities in AA patients and the frequency of Fanconi Anemia (FA) in morphologically normal AA patients in eastern India. Ethical clearances were obtained from both institutions involved in this study. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698559PMC
November 2017
3 Reads

Luminol-amplified chemiluminescence detects mainly superoxide anion produced by human neutrophils.

Am J Blood Res 2017 25;7(4):41-48. Epub 2017 Jul 25.

INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'InflammationParis, France.

Reactive oxygen species (ROS) are produced by numerous biological systems and by several phagocytes such as neutrophils and macrophages. ROS include mostly superoxide anion, hydrogen peroxide, singlet oxygen and hydroxyl radical, which are involved in a variety of biological processes such as immunity, inflammation, apoptosis and cell signaling. Thus, there is a need for a sensitive and reliable method to measure ROS. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545213PMC
July 2017
88 Reads

Treatment of older patients with acute myeloid leukemia (AML): revised Canadian consensus guidelines.

Am J Blood Res 2017 25;7(4):30-40. Epub 2017 Jul 25.

Princess Margaret Cancer Centre, University of TorontoToronto, ON, Canada.

The treatment of acute myeloid leukemia (AML) in older patients is undergoing rapid changes, with a number of important publications in the past five years. Because of this, a group of Canadian leukemia experts has produced an update to the Canadian Consensus Guidelines that were published in 2013, with several new agents recommended, subject to availability. Recent studies have supported the survival benefit of induction chemotherapy for patients under age 80, except those with major co-morbidities or those with adverse risk cytogenetics who are not candidates for allogeneic hematopoietic stem cell transplantation (HSCT). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545212PMC
July 2017
68 Reads

Erratum: Efficacy and safety of ClairYg®, a ready-to-use intravenous immunoglobulin, in adult patients with primary immune thrombocytopenia.

Am J Blood Res 2017 15;7(3):29. Epub 2017 Jun 15.

Department of Internal Medicine, University Hospital Henri MondorFrance.

[This corrects the article on p. 1 in vol. 7, PMID: 28203488. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498821PMC
June 2017
40 Reads

Factors affecting the body mass index, haemoglobin and serum ferritin level in students.

Am J Blood Res 2017 15;7(3):18-28. Epub 2017 Jun 15.

Department of Community Medicine, Peoples University of Medical and Health Sciences for WomenNawabshah (SBA), Pakistan.

Ferritin is a protein found in reticuloendothelial system and does not work only as a mid-size protein during Hemoglobin synthesis but also as storage protein for iron delivery. This cross sectional study was conducted in District Shaheed Benazirabad during the period of August 2015 to March 2016, for obtaining credible and consolidated data. In present study we investigated BMI, Hb and S. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498820PMC
June 2017
23 Reads

Concomitant lymphoplasmacytic lymphoma and plasma cell myeloma, a diagnostic challenge.

Am J Blood Res 2017 15;7(2):10-17. Epub 2017 Apr 15.

Department of Pathology and Laboratory Medicine, School of Medicine, Indiana UniversityIndianapolis, Indiana 46202, USA.

Background: Lymphoplasmacytic lymphoma and plasma cell myeloma are two B cell lymphoproliferative neoplasms derived from mature B-lymphocytes in different differentiation stages. The coexistence of these two tumors in the same patient is exceedingly rare and can be difficult to diagnose.

Case Presentation: A 76-year-old male presented with a pathologic fracture after a fall. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435600PMC
April 2017
29 Reads

Efficacy and safety of ClairYg, a ready-to-use intravenous immunoglobulin, in adult patients with primary immune thrombocytopenia.

Am J Blood Res 2017 15;7(1):1-9. Epub 2017 Jan 15.

Department of Internal Medicine, University Hospital Henri Mondor France.

Purpose: The present study was designed to assess the efficacy and safety of IGNG that is a new liquid, saccharose and maltose-free highly purified ready-to-use 5% intravenous immunoglobulin (IVIg), in primary immune thrombocytopenic patients with severe thrombocytopenia.

Methods: Nineteen adults with a platelet count ≤ 25 × 10/L received a single dose of IGNG (1 g/kg) on Day 1, with a second identical dose on Day 3 if needed. Patients were followed for 30 days. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306448PMC
January 2017
37 Reads

DDX6 transfers P-TEFb kinase to the AF4/AF4N (AFF1) super elongation complex.

Am J Blood Res 2016 15;6(3):28-45. Epub 2016 Sep 15.

Institute of Pharmaceutical Biology/DCAL, Goethe-University of Frankfurt, Biocenter Max-von-Laue-Str. 9, D-60438 Frankfurt/Main, Germany.

AF4/AFF1 and AF5/AFF4 are both backbones for the assembly of "super elongation complexes" (SECs) that exert 2 distinct functions after the recruitment of P-TEFb from the 7SK snRNP: (1) initiation and elongation of RNA polymerase II gene transcription, and (2) modification of transcribed gene regions by distinct histone methylation patterns. In this study we aimed to investigate one of the initial steps, namely how P-TEFb is transferred from 7SK snRNPs to the SECs. In particular, we were interested in the role of DDX6 that we have recently identified as part of the AF4 complex. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030405PMC
September 2016

Pesg PNH diagnosis, follow-up and treatment guidelines.

Am J Blood Res 2016 5;6(2):19-27. Epub 2016 Aug 5.

Department of Hematology, Ege UniversityIzmir, Turkey; On behalf of PNH Education and Study Group (PESG).

PNH Education and Study Group (PESG) have been established in December 2013 as a non-profit, independent, medical organization www.pesg.org. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981648PMC
August 2016
54 Reads
1 Citation

Maytansinoid immunoconjugate IMGN901 is cytotoxic in a three-dimensional culture model of multiple myeloma.

Am J Blood Res 2016 18;6(1):6-18. Epub 2016 May 18.

Department of Biological Sciences, Purdue UniversityWest Lafayette, IN, 47907, USA; Current address: Ixchel ScientificSan Jose, CA.

Environmental-mediated drug-resistance (EM-DR) presents a major challenge for therapeutic development. Tissue microenvironment in the form of extracellular matrix, soluble factors, and stroma contribute to EM-DR. In multiple myeloma (MM), drug-resistance has hindered treatment success with 5-year survival rates remaining <50%. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913235PMC
June 2016
2 Reads

Methotrexate-associated primary cutaneous CD30-positive cutaneous T-cell lymphoproliferative disorder: a case illustration and a brief review.

Am J Blood Res 2016 18;6(1):1-5. Epub 2016 May 18.

Division of Hematology and Medical Oncology, James Graham Brown Cancer Center, University of Louisville Health Sciences Center Louisville, Kentucky, USA.

Methotrexate (MTX) is a commonly used anti-metabolite agent. Increased risk of lymphoproliferative disorders (LPD) in patients with rheumatoid arthritis (RA) has been documented with the prolonged use of immunosuppressive medications such as MTX. This is thought to be the result of immune dysregulation and/or chronic immune stimulation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913234PMC
June 2016
11 Reads

PNH is a debilitating, fatal but treatable disease: same disease, different clinical presentations.

Am J Blood Res 2015 15;5(1):30-3. Epub 2015 Jun 15.

Department of Hematology, Ege University Bornova, Izmir, Turkey ; PNH Education and Study Group (PESG) Turkey.

Paroxysmal nocturnal hemoglobinuria (PNH) is a disease characterized by chronic persistent hemolysis, multi-organ damage and eventually multiple organ failure. PNH develops as a result of increased sensitivity to complement due to an acquired deficiency of certain glycosylphosphatidylinositol (GPI)-linked proteins. The clinical presentation of PNH varies greatly from one patient to another. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497495PMC
July 2015
9 Reads

Type B lactic acidosis: a rare but life threatening hematologic emergency. A case illustration and brief review.

Am J Blood Res 2015 15;5(1):25-9. Epub 2015 Jun 15.

Division of Hematology and Medical Oncology, James Graham Brown Cancer Center, University of Louisville Health Sciences Center Louisville, Kentucky, USA.

Major strides have been made in improving the treatment of medical emergencies associated with malignancies. Nonetheless, metabolic emergencies in cancer patients can often times be life-threatening. Type B lactic acidosis is a rare but potentially fatal paraneoplastic phenomenon that has been described in association with hematologic and solid malignancies and portends a poor prognosis if not rapidly recognized and treated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497494PMC
July 2015
2 Reads

AF4 and AF4N protein complexes: recruitment of P-TEFb kinase, their interactome and potential functions.

Am J Blood Res 2015 15;5(1):10-24. Epub 2015 Jun 15.

Institute of Pharmaceutical Biology, Goethe-University of Frankfurt Biocenter, Max-von-Laue-Str. 9, D-60438 Frankfurt/Main, Germany.

AF4/AFF1 and AF5/AFF4 are the molecular backbone to assemble "super-elongation complexes" (SECs) that have two main functions: (1) control of transcriptional elongation by recruiting the positive transcription elongation factor b (P-TEFb = CyclinT1/CDK9) that is usually stored in inhibitory 7SK RNPs; (2) binding of different histone methyltransferases, like DOT1L, NSD1 and CARM1. This way, transcribed genes obtain specific histone signatures (e.g. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497493PMC

Multidisciplinary clinical management of paroxysmal nocturnal hemoglobinuria.

Am J Blood Res 2015 15;5(1):1-9. Epub 2015 Jun 15.

Department of Hematology, Ege University Izmir.

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease caused by clonal expansion of one or more hematopoietic stem cell (HSC) lines due to a somatic mutation of the phosphatidylinositol glycan anchor (PIG-A) gene located on Xp22.1. PNH incidence is 1. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497492PMC
July 2015
60 Reads

Red cell parameters in infant and children from the Arabian Peninsula.

Am J Blood Res 2015 25;5(2):101-7. Epub 2015 Dec 25.

Department of Pediatrics, United Arab Emirates University Al-Ain, UAE.

α+-Thalassemia trait and iron deficiency anemia are frequent causes of microcytosis and a common diagnostic challenge in Arabian children. In this study, their prevalences and effects on the red cell parameters were evaluated in 28,457 children aged one day to 6 years. α+-Thalassemia trait was considered to be present when mean cell volume (MCV) was <94 fL at birth and iron deficiency anemia when red cell distribution width (RDW) was >14. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769353PMC
April 2016
11 Reads

Evaluation of immunomodulatory drugs in multiple myeloma: single center experience.

Am J Blood Res 2015 25;5(2):95-100. Epub 2015 Dec 25.

Department of Hematology, Ege University Medical School Izmir, Turkey.

Objective: Multiple myeloma (MM) comprises 1% of all cancers and 10% of hematologic malignancies and known as an incurable disease. The introduction of immunomodulatory drugs (IMiDs) has brought a major shift in therapeutic paradigm in the treatment of newly diagnosed and relapsed/refractory MM patients. The aim of this study was to evaluate the relationship between response status and hematological parameters in patients with MM treated with thalidomide or lenalidomide. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769352PMC
April 2016
11 Reads

Therapy-related myelodysplastic syndrome: a case study.

Am J Blood Res 2015 25;5(2):91-4. Epub 2015 Dec 25.

Department of Hematology, Osaka General Hospital of West Japan Railway Company 1-2-22 Matsuzaki-cho, Abeno-ku, Osaka 545-0053, Japan.

We present a case of therapy-related myelodyspastic syndrome in which the t(3;8)(q26;q24) translocation appeared, even though no chromosomal abnormalities were found at the initial diagnosis of acute myeloid leukemia. To the best of our knowledge, there have only been around 20 reported cases of myeloid malignancies involving t(3;8)(q26;q24). We discuss the characteristics of t(3;8)(q26;q24) along with a review of literature. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769351PMC
April 2016
2 Reads

A nationwide non-interventional epidemiological data registry on myelodysplastic syndromes in Lebanon.

Am J Blood Res 2015 25;5(2):86-90. Epub 2015 Dec 25.

Department of Laboratory Medicine, Rizk Hospital University Medical Center Beirut, Lebanon.

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by peripheral blood cytopenias, blood cells dysplasia, and increased risk for progression to acute leukemia.Physicians should be vigilant in diagnosing MDS and should be aware of the contemporary therapies that are always in progress. Most of the data on MDS epidemiology and management comes from developed countries. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769350PMC
April 2016
47 Reads

Clinical grade isolation of regulatory T cells from G-CSF mobilized peripheral blood improves with initial depletion of monocytes.

Am J Blood Res 2015 25;5(2):79-85. Epub 2015 Dec 25.

Division of Hematology/Oncology, University of Illinois at ChicagoChicago, IL, USA; Cancer Center, University of IllinoisChicago, IL, USA.

Clinical isolation of circulating CD4(+)CD25(+) regulatory T cells (Tregs) from peripheral blood mononuclear cells is usually performed by CD4(+) cell negative selection followed by CD25(+) cell positive selection. Although G-CSF mobilized peripheral blood (G-PBSC) contains a high number of Tregs, a high number of monocytes in G-PBSC limits Treg isolation. Using a small scale device (MidiMACS, Miltenyi) we initially demonstrated that an initial depletion of monocytes would be necessary to obtaina separation of CD4(+)CD25(+)FoxP3(+)CD127(-) cells from G-PBSC (G-Tregs) with a consistent purity >70% and inhibitory activity of T cell alloreactivity in-vitro. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769349PMC
April 2016
2 Reads

Fixed nuclei as alternative template of BIOMED-2 multiplex polymerase chain reaction for immunoglobulin gene clonality testing in B-cell malignancies.

Am J Blood Res 2015 25;5(2):62-78. Epub 2015 Dec 25.

Department of Pathology, West China Hospital, Sichuan University China.

Evaluation of immunoglobulin (Ig) gene rearrangements with BIOMED-2 multiplex PCR has become a standard detection of clonality in mature B cell malignancies. Conventionally, this method is relatively labor-intensive and time-consuming, as it requires DNA isolation from bone marrow aspirates (BM) or peripheral blood (PB) in patients with BM or PB involvement. On the other hand, fluorescence in situ hybridization (FISH) is routinely used as genetic screening in B cell malignancies, but the surplus fixed nuclei initially prepared for FISH usually turn useless afterwards. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769348PMC
April 2016
15 Reads

A novel interaction between megakaryocytes and activated fibrocytes increases TGF-β bioavailability in the Gata1(low) mouse model of myelofibrosis.

Am J Blood Res 2015 25;5(2):34-61. Epub 2015 Dec 25.

Biomedical and Neuromotory Sciences, Alma Mater UniversityBologna, Italy; Tisch Cancer Institute, Ichan School of Medicine at Mount SinaiNew York, NY, USA.

Despite numerous circumstantial evidences, the pathogenic role of TGF-β in primary myelofibrosis (PMF), the most severe of the Philadelphia-negative myeloproliferative neoplasms, is still unclear because of the modest (2-fold) increases in its plasma levels observed in PMF patients and in the Gata1(low) mouse model. Whether myelofibrosis is associated with increased bioavailability of TGF-β bound to fibrotic fibres is unknown. Transmission electron-microscopy (TEM) observations identified that spleen from PMF patients and Gata1(low) mice contained megakaryocytes with abnormally high levels of TGF-β and collagen fibres embedded in their cytoplasm. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769347PMC
April 2016
2 Reads

Concomitant a novel ALAS2 mutation and GATA1 mutation in a newborn: a case report and review of the literature.

Am J Blood Res 2014 5;4(1):41-5. Epub 2014 Sep 5.

Department of Pathology, Children's Healthcare of Atlanta, Emory University Atlanta, GA, 30322, USA.

GATA-1, an X-linked gene, encodes a transcription factor that plays a role in erythropoiesis and megakaryopoiesis. GATA-1 mutations have been associated with various diseases, such as X-linked thrombocytopenia. ALAS2 is an X-linked erythroid-specific isoenzyme expressed during erythropoiesis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165116PMC
September 2014

Multiplex amplification refractory mutation system (MARMS) for the detection of β-globin gene mutations among the transfusion-dependent β-thalassemia Malay patients in Kelantan, Northeast of Peninsular Malaysia.

Am J Blood Res 2014 5;4(1):33-40. Epub 2014 Sep 5.

Department of Pediatrics, School of Medical Sciences, Universiti Sains Malaysia Malaysia.

The aim of this study was to adapt MARMS with some modifications to detect beta mutation in our cohort of thalassemia patients. We focused only on transfusion-dependent thalassemia Malay patients, the predominant ethnic group (95%) in the Kelantanese population. Eight mutations were identified in 46 out of 48 (95. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165115PMC
September 2014
46 Reads
1 Citation

Transfusion-independent β(0)-thalassemia after bone marrow transplantation failure: proposed involvement of high parental HbF and an epigenetic mechanism.

Am J Blood Res 2014 5;4(1):27-32. Epub 2014 Sep 5.

Department of Cell Biology, Erasmus MC P.O. box 2040, 3000 CA Rotterdam, The Netherlands.

Currently, bone marrow transplantation is the only curative treatment for β-thalassemia and sickle cell disease. In rare cases, sustained and full fetal hemoglobin production was observed in patients after failure of bone marrow transplantation. This rendered the patients transfusion-free, despite genetic disease and transplant rejection. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165118PMC
September 2014
7 Reads

STAT5 N-domain deleted isoforms are naturally occurring hypomorphs partially rescued in hematopoiesis by transgenic Bcl-2 expression.

Am J Blood Res 2014 5;4(1):20-6. Epub 2014 Sep 5.

Department of Pediatrics, Division of Hematology-Oncology-BMT, Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta and Emory University School of Medicine Atlanta, GA, USA.

Signal transducer and activator of transcription 5 (STAT5) is a critical regulator of normal and leukemic lympho-myeloid development through activation downstream of early-acting cytokines, their receptors, and JAKs. Truncation of STAT5 can be mediated through alternative translation initiation from an internal start codon giving rise to N-terminally deleted isoforms. To determine whether these isoforms could be detected naturally in normal murine tissues, Western blot analyses were performed on heart, lung, brain, spleen, liver, and kidney. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165113PMC
September 2014
2 Reads
1 Citation

The transcription factor Miz-1 is required for embryonic and stress-induced erythropoiesis but dispensable for adult erythropoiesis.

Am J Blood Res 2014 5;4(1):7-19. Epub 2014 Sep 5.

Institut de Recherches Cliniques de Montréal, IRCM Montréal, Canada ; Division of Experimental Medicine, McGill University Montreal, Canada ; Département de Microbiologie, Infectiologie et Immunologie Montréal, Canada.

Myc-interacting zinc finger protein 1 (Miz-1) is a BTB/POZ domain transcription factor that regulates complex processes such as proliferation and apoptosis. Constitutively Miz-1-deficient animals arrest embryonic development at E14.5 due to severe anemia and fetal liver cells lacking Miz-1 show a high cell death rate and a significant reduction of mature Ter119(+)ckit(-) or Ter119(+)CD71(-/low) cells. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165114PMC
September 2014
2 Reads

Renal complications of beta-thalassemia major in children.

Am J Blood Res 2014 5;4(1):1-6. Epub 2014 Sep 5.

Pediatric Hematology Unit, Department of Pediatrics, Mansoura University Mansoura, Egypt.

The success that has been made in the care of patients with thalassemia has led to the emergence of unrecognized complications including several renal abnormalities. Chronic anemia and iron overload as well as the use of iron chelator are believed to lie behind these abnormalities. Many investigators document the presence of tubular dysfunction and abnormalities in glomerular filtration rate in these patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165117PMC
September 2014
12 Reads

Chronic myelogenous leukemia after postoperative adjuvant S-1 therapy for rectal cancer: a case report.

Am J Blood Res 2013 18;3(4):286-9. Epub 2013 Dec 18.

Department of Hematology, Seichokai Fuchu Hospital 1-10-17 Hiko-cho, Izumi, Osaka 594-0076, Japan.

We report a case in which chronic myelogenous leukemia (CML) developed after postoperative adjuvant S-1 therapy for rectal cancer. A 56-year-old man was diagnosed with rectal adenocarcinoma, which was treated with abdominoperineal resection followed by a year of adjuvant S-1 therapy. At 39 postoperative months, he was diagnosed with CML. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875274PMC
January 2014
10 Reads

N-cadherin impedes proliferation of the multiple myeloma cancer stem cells.

Am J Blood Res 2013 18;3(4):271-85. Epub 2013 Dec 18.

Department of Biological Sciences, Purdue University West Lafayette, IN, 47907, USA.

Multiple myeloma (MM) is an incurable malignancy of the plasma cells localized to the bone marrow. A rare population of MM cancer stem cells (MM-CSCs) has been shown to be responsible for maintaining the pull of residual disease and to contribute to myeloma relapse. The stem cells are found in a bone marrow niche in contact with the stromal cells that are responsible for maintaining the proliferative quiescence of the MM-CSC and regulate its self-renewal and differentiation decisions. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875273PMC
January 2014
20 Reads

Granulocytic sarcoma: a systematic review.

Am J Blood Res 2013 Dec 18;3(4):265-70. Epub 2013 Dec 18.

Department of Molecular Biology and Genetics, Science Faculty, Izmir Institute of Technology Urla, Izmir, Turkey.

Granulocytic sarcoma also called myeloid sarcoma is an extramedullary tumor of immature granulocytic cells. It is a rare entity, and mostly accompanied by acute myeloid leukemia. It is observed during the course of myeloproliferative disorders especially in chronic myeloid leukemia and myelodysplastic syndromes. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875275PMC
December 2013
10 Reads

Concomitant use of radiotherapy and two topoisomerase inhibitors to treat adult T-cell leukemia with a radiotherapy-resistant bulky disease: a case series.

Authors:
Kosuke Obama

Am J Blood Res 2014 15;4(2):106-9. Epub 2014 Dec 15.

Department of Hematology, Imakiire General Hospital 4-16 Shimotatsuocho, Kagoshima 892-8502, Japan.

Concomitant chemoradiotherapy is established as the standard treatment to improve the prognosis of several types of solid tumor, but has not been the general practice for hematological malignancies. Here, I report two cases of adult T-cell leukemia (ATL) with a radiotherapy-resistant bulky disease treated with concomitant radiotherapy and two topoisomerase inhibitors: etoposide (VP-16) and irinotecan (CPT-11). Patient 1 was a 78-year-old man with chemotherapy-resistant inguinal bulky mass. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351648PMC

Imported visceral leishmaniasis - unexpected bone marrow diagnosis in a patient with fever, pancytopenia, and splenomegaly.

Am J Blood Res 2014 15;4(2):101-5. Epub 2014 Dec 15.

Department of Internal Medicine, Central Hospital of Bolzano/Bozen Bolzano/Bozen (BZ), Italy.

Leishmaniasis is spreading from mediterranean countries to the north of Europe. The Alps are not an endemic region and there are only few reports of sporadic cases. We report the case of a 72 year old male who presented after a syncope with fever, cough and a sacral skin rash. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348797PMC
March 2015
8 Reads

Long-lasting complete response to imatinib in a patient with systemic mastocytosis exhibiting wild type KIT.

Am J Blood Res 2014 15;4(2):93-100. Epub 2014 Dec 15.

Ludwig Boltzmann Cluster Oncology, Medical University of Vienna Austria ; Department of Dermatology, Medical University of Vienna Austria.

Systemic mastocytosis (SM) is a hematopoietic disorder characterized by abnormal expansion of mast cells (MCs) in visceral organs. The skin is involved in most cases. In adult patients the transforming KIT mutation D816V is usually present and confers resistance against imatinib. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351647PMC
March 2015
6 Reads

Comparative of three methods (ELIZA, MAIPA and flow cytometry) to determine anti-platelet antibody in children with ITP.

Am J Blood Res 2014 15;4(2):86-92. Epub 2014 Dec 15.

Department of Herbal Medicine, Pars Biosciences Research Center KS, USA.

Immune (idiopathic) thrombocytopenic purpurea (ITP) is an autoimmune disease characterized by the increased anti-platelet antibodies in the patient's sera and decreased platelets in the blood circulation. This study has determined and characterized the antiplatelet glycoproteins in children with ITP. Thirty eight children, who were hospitalized with clinical signs of ITP in Mofid Children Hospital (Tehran, Iran) during 18 months, went under our clinical studies in a research project. Read More

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http://www.ajblood.us/files/ajbr0002009.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348796PMC
March 2015
15 Reads

Dkk-1 and IL-7 in plasma of patients with multiple myeloma prevent differentiation of mesenchymal stem cells into osteoblasts.

Am J Blood Res 2014 15;4(2):73-85. Epub 2014 Dec 15.

Department of Biological Sciences, Purdue University West Lafayette, IN, USA ; Current affiliation: Ixchel Scientific USA.

Bone disease is the leading cause of morbidity associated with multiple myeloma (MM). Lytic bone lesions have been detected in 90% of patients diagnosed with MM and present a great therapeutic challenge. After the removal of the tumor burden, the bone lesions persist and the bone remodeling homeostasis is not restored even in patients in clinical remission. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348795PMC
March 2015
5 Reads

The role of glucocorticoid receptor (GR) polymorphisms in human erythropoiesis.

Am J Blood Res 2014 15;4(2):53-72. Epub 2014 Dec 15.

Tisch Cancer Institute, Mount Sinai School of Medicine New York, NY 10029, USA ; Istituto Superiore di Sanita' Viale Regina Elena 299 Italy.

Glucocorticoids are endogenous steroid hormones that regulate several biological functions including proliferation, differentiation and apoptosis in numerous cell types in response to stress. Synthetic glucocorticoids, such as dexamethasone (Dex) are used to treat a variety of diseases ranging from allergy to depression. Glucocorticoids exert their effects by passively entering into cells and binding to a specific Glucocorticoid Receptor (GR) present in the cytoplasm. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348794PMC
March 2015
12 Reads

Towards an off-the-shelf vaccine therapy targeting shared B-cell tumor idiotypes.

Am J Blood Res 2014 15;4(2):46-52. Epub 2014 Dec 15.

Department of Lymphoma and Myeloma, M.D. Anderson Cancer Center Houston, TX, USA ; Center for Cancer Immunology Research, M.D. Anderson Cancer Center Houston, TX, USA.

The ideal tumor antigen is one expressed selectively by the tumor, present in all cancer patients, essential for tumor survival and nonetheless able to induce both humoral and cellular immune response. The personalized idiotype (Id) of the surface immunoglobulin is a tumor specific antigen in that it is expressed on clonal B-cell tumors, mediates B-cell survival, and induces tumor specific immunity in both human and animal models. With the availability of monoclonal antibodies against B cells, such as rituximab, the cellular immune response mediated by specific T cells has gained more importance as a combination therapy for the complete elimination of residual tumor cells in lymphoma and myeloma. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348793PMC
March 2015
3 Reads

Romiplostim for delayed platelet recovery and secondary thrombocytopenia following allogeneic stem cell transplantation.

Am J Blood Res 2013 19;3(3):260-4. Epub 2013 Aug 19.

Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center Houston, Texas, USA ; Department Of Hematology-Oncology, National University Cancer Institute Singapore.

Delayed recovery of platelet count post allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been associated with worse transplant outcomes. Thrombopoietic agents have been successfully used in immune mediated thrombocytopenia or thrombocytopenia from bone marrow failure syndromes; however, the experience regarding their use after allo-HSCT is limited. Here we report on the safety and efficacy of romiplostim used in 3 consecutive patients with thrombocytopenia post allogeneic transplantation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755526PMC
September 2013
8 Reads

Costs and quality of life in patients with myelodysplastic syndromes.

Am J Blood Res 2013 19;3(3):246-59. Epub 2013 Aug 19.

Springer Healthcare Italia S.r.l. Milano.

Myelodysplastic syndromes (MDS) encompass a range of myeloid neoplasms characterised by a defect in haematopoietic stem cell maturation, resulting in peripheral cytopenias. As a major consequence, most MDS patients become anaemic, so as to require red blood cell transfusions. To investigate the costs and the impact on quality of life (QOL) of MDS-separately in transfusion-independent (TI) and -dependent (TD) patients-a literature search was conducted. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755523PMC
September 2013
6 Reads

Detection of immune suppressive neutrophils in peripheral blood samples of cancer patients.

Am J Blood Res 2013 19;3(3):239-45. Epub 2013 Aug 19.

Department of Pathology, UMass Memorial Medical Center and University of Massachusetts Medical School Worcester, MA, USA.

Neutrophils provide first-line defense against infections and are potent effectors in innate and adaptive immunity. Recently neutrophils have been shown to play important roles in multiple antitumor reactions. A subset of mature neutrophils in human systemic inflammation has been identified as a unique circulating population of myeloid cells, which is capable of inhibiting T cell responses. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755524PMC
September 2013
4 Reads

Treatment of severe steroid resistant acute GVHD with mesenchymal stromal cells (MSC).

Am J Blood Res 2013 19;3(3):225-38. Epub 2013 Aug 19.

Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah-Hebrew University Medical Center Jerusalem.

Background: Several studies revealed that MSC from human bone marrow can downregulate graft-versus-host disease (GVHD) after allogeneic HSCT.

Methods: Herein we present 50 patients with acute GVHD who got 74 (1-4) MSC infusions for 54 separate episodes of aGVHD.

Results: aGVHD was defined as steroid resistant grade IV aGVHD in 42 cases. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755522PMC
September 2013
56 Reads