1,272 results match your criteria American journal of Alzheimer's disease and other dementias[Journal]


Risk Factors for Cardiovascular Events in Patients on Antidementia Medications.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520922380

Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.

Objective: To identify characteristics associated with an increased risk of cardiovascular events in patients diagnosed with Alzheimer disease (AD) and treated with antidementia medications.

Methods: Demographics, diagnoses, and medication usage of 30 433 Medicare patients were analyzed using 2006 to 2013 claims data and a combined model of screening, ranking and stepwise logistic regressions to evaluate factors associated with composite outcomes of 6 cardiovascular events.

Results: Incidence rate of at least 1 cardiovascular event was 25. Read More

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http://dx.doi.org/10.1177/1533317520922380DOI Listing

Association Between Subjective Cognitive Decline and Social and Emotional Support in US Adults.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520922392

Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA.

Subjective cognitive decline (SCD) has been linked to Alzheimer's Disease in the literature. However, little is known about whether SCD is associated with social/emotional support (SES). To investigate this association, this study utilized the 2015 and 2016 Behavioral Risk Factor Surveillance System data. Read More

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http://dx.doi.org/10.1177/1533317520922392DOI Listing
May 2020
1.426 Impact Factor

A Metabolic Imaging Study of Lexical and Phonological Naming Errors in Alzheimer Disease.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520922390

Milan Center for Neuroscience (NeuroMI), Milan, Italy.

Patients with Alzheimer disease (AD) produce a variety of errors on confrontation naming that indicate multiple loci of impairment along the naming process in this disease. We correlated brain hypometabolism, measured with 18fluoro-deoxy-glucose positron emission tomography, with semantic and formal errors, as well as nonwords deriving from phonological errors produced in a picture-naming test by 63 patients with AD. Findings suggest that neurodegeneration leads to: (1) phonemic errors, by interfering with phonological short-term memory, or with control over retrieval of phonological or prearticulatory representations, within the left supramarginal gyrus; (2) semantic errors, by disrupting general semantic or visual-semantic representations at the level of the left posterior middle and inferior occipitotemporal cortex, respectively; (3) formal errors, by damaging the lexical-phonological output interface in the left mid-anterior segment of middle and superior temporal gyri. Read More

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http://dx.doi.org/10.1177/1533317520922390DOI Listing

Evaluating Semantic Knowledge Through a Semantic Association Task in Individuals With Dementia.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520917294

Department of Neurology, MultiMedica Hospital, Castellanza, Italy.

Conceptual knowledge is supported by multiple semantic systems that are specialized for the analysis of different properties associated with object concepts. Various types of semantic association between concrete concepts-categorical (CA), encyclopedic (EA), functional (FA), and visual-encyclopedic (VEA) associations-were tested through a new picture-to-picture matching task (semantic association task, SAT). Forty individuals with Alzheimer's disease (AD), 13 with behavioral variant of frontotemporal dementia (bv-FTD), 6 with primary progressive aphasia (PPA), and 37 healthy participants were tested with the SAT. Read More

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http://dx.doi.org/10.1177/1533317520917294DOI Listing

Whole-Blood Levels of MicroRNA-9 Are Decreased in Patients With Late-Onset Alzheimer Disease.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520911573

Medical Faculty, University of Brasília, Brasília, Federal District, Brazil.

Recent evidence suggests changes in circulating microRNA levels may be promising biomarkers for the clinical diagnosis of Alzheimer disease (AD). We hypothesized that whole-blood microRNAs may be useful to identify individuals with established AD. For this purpose, a sample of community-dwelling women (≥55 years old) carrying the ∊4 allele were clinically evaluated using the American Psychiatric Association/, Fourth edition and the Alzheimer Disease Assessment Scale-Cognitive Subscale criteria to diagnose probable AD, and the Clinical Dementia Rating scale to stage the dementia. Read More

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http://dx.doi.org/10.1177/1533317520911573DOI Listing
April 2020
1.426 Impact Factor

Loneliness and Burden Perceived by Family Caregivers of Patients With Alzheimer Disease.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520917788

Department of Psychiatry and Psychotherapy A, General Hospital Hall, Hall in Tirol, Austria.

Background: The present study aimed at investigating loneliness and burden experienced by family members caring for relatives diagnosed with Alzheimer disease.

Methods: Participants were 40 caregivers of inpatients with Alzheimer disease. Correlation and multiple regression analyses were conducted to investigate whether caregivers' loneliness (uni- and multidimensional) and burden are associated with and predicted by (1) specific caregiver characteristics and/or (2) patients' dementia severity and neuropsychiatric symptoms. Read More

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http://dx.doi.org/10.1177/1533317520917788DOI Listing

Addressing Behavioral Symptoms of Dementia Through STAR-VA Implementation: Do Outcomes Vary by Behavior Type?

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520911577

Office of Mental Health and Suicide Prevention, Department of Veterans Affairs, Washington, DC, USA.

Objectives: The STAR-VA program in Veterans Health Administration Community Living Centers (CLCs, nursing home settings) trains teams to implement a psychosocial intervention with residents with behavioral symptoms of dementia (BSD).

Methods: Across 71 CLCs, 302 residents selected as training cases had target behaviors categorized into one of 5 types: physically aggressive (PA), physically nonaggressive, verbally aggressive, verbally nonaggressive, and behavior deficit (BD).

Results: Across all groups, there were significant declines in team-rated behavior frequency (36%) and severity (44%), agitation (10%), distress behaviors (42%), depression (17%), and anxiety (20%). Read More

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http://dx.doi.org/10.1177/1533317520911577DOI Listing

How Evidence-Based Practice (EBP) Informs Speech-Language Pathology for Primary Progressive Aphasia.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520915365

Department of Cognitive Science, Macquarie University, Sydney, New South Wales, Australia.

Amelioration of communication impairment in primary progressive aphasia (PPA) is an area of clinical importance and current research. Speech-language pathologists (SLPs) have a range of skills and interventions to support communication in PPA; however, underrecognition of their role and low referral rates is an ongoing concern. The EBP conceptualization of evidence-based practice comprises 3 components: research-based evidence, practice-based evidence, and informed patient preferences. Read More

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http://dx.doi.org/10.1177/1533317520915365DOI Listing

Insulin Resistance Is Independently Associated With Enlarged Perivascular Space in the Basal Ganglia in Nondiabetic Healthy Elderly Population.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520912126

Department of Neurology, Shanghai Tenth People's Hospital of Nanjing Medical University, Shanghai, People's Republic of China.

Objectives: To investigate the association between insulin resistance (IR) and enlarged perivascular space (EPVS) in the basal gangliain nondiabetic healthy elderly population.

Methods: A total of 235 nondiabetic healthy elderly population were recruited. A 3-level scale was used to evaluate the burden of EPVSs. Read More

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http://dx.doi.org/10.1177/1533317520912126DOI Listing

BESI: Behavioral and Environmental Sensing and Intervention for Dementia Caregiver Empowerment-Phases 1 and 2.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520906686

Department of Electrical and Computer Engineering, University of Virginia, Charlottesville, VA, USA.

Background And Objectives: Caregiver burden associated with dementia-related agitation is one of the commonest reasons a community-dwelling person with dementia (PWD) transitions to a care facility. Behavioral and Environmental Sensing and Intervention for Dementia Caregiver Empowerment (BESI) is a system of body-worn and in-home sensors developed to provide continuous, noninvasive agitation assessment and environmental context monitoring to detect early signs of agitation and its environmental triggers.

Research Design And Methods: This mixed methods, remote ethnographic study is explored in a 3-phase, multiyear plan. Read More

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http://dx.doi.org/10.1177/1533317520906686DOI Listing

Combined Influences of Dementia Exposure and Personality on Self-Reported Memory Problems.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519899792

Canyonville, OR, USA.

The current study investigated whether having a first-degree relative with dementia influenced older adults' self-reported memory, if personality traits moderated these associations, and whether these associations differed by the type of item asked (ie, frequency of memory problems vs perceived memory decline). Data drawn from the Einstein Aging study included 454 older adults ( = 76.64, standard deviation = 4. Read More

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http://dx.doi.org/10.1177/1533317519899792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135876PMC
January 2021

Antidiabetic Drugs for the Risk of Alzheimer Disease in Patients With Type 2 DM Using FAERS.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519899546

Faculty of Pharmacy and Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics, Josai University, Sakado, Saitama, Japan.

Alzheimer disease (AD) may develop after the onset of type 2 diabetes mellitus (T2DM), and the risk of AD may depend on the antidiabetic drug administered. We compared the risk of AD among 66 085 patients (≥ 65 years) with T2DM (1250 having concomitant AD) who had been administered antidiabetic drug monotherapy for T2DM who had voluntarily reported themselves in the Food and Drug Administration Adverse Event Reporting System. The risk of AD from the use of different antidiabetic drug monotherapies compared to that of metformin monotherapy was assessed by logistic regression. Read More

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http://dx.doi.org/10.1177/1533317519899546DOI Listing

Primary Progressive Aphasia Education and Support Groups: A Clinical Evaluation.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519895638

Department of Cognitive Science, Macquarie University, Sydney, New South Wales, Australia.

Objectives: To evaluate the benefits of a primary progressive aphasia (PPA) education and support session for people with PPA (pwPPA) and their caregivers.

Method: Thirty-eight individuals (20 pwPPA, 18 caregivers) were invited to participate in the study. Twenty-five individuals (12 pwPPA, 13 caregivers) completed questionnaires before and after an education and support group session provided by a speech pathologist and a clinical psychologist. Read More

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http://dx.doi.org/10.1177/1533317519895638DOI Listing
February 2020

Nutritional and Functional Indicators and Their Association With Mortality Among Older Adults With Alzheimer's Disease.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520907168

Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal.

This study investigated how different nutritional and functional status indicators are associated with mortality in patients with Alzheimer's disease (AD). A prospective cohort study was conducted among 79 community-dwelling older adults with AD. Follow-up was 60 months. Read More

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http://dx.doi.org/10.1177/1533317520907168DOI Listing
February 2020

Caregiver Psychological Distress: Longitudinal Relationships With Physical Activity and Diet.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520904554

Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.

Given limited longitudinal research with caregivers (CGs, n = 122) of spouses with Alzheimer disease, and demographically matched noncaregivers (NCGs, n = 117), we compared these groups on psychological distress (anxiety, depression), burden, and health behaviors over 2 years. Analyses examined group differences in relationships of micronutrient recommended daily allowances (RDAs) and physical activity considering hours of care, psychological distress, and burden. Participants were measured and assessed on whether they met micronutrient intake and physical activity totaled over an average week. Read More

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http://dx.doi.org/10.1177/1533317520904554DOI Listing
February 2020

Anxiety and Depression Are Not Related to Increasing Levels of Burden and Stress in Caregivers of Patients With Alzheimer's Disease.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519899544

Neurology Department, Multimedica Hospital, Castellanza, Italy.

Sixty-nine dyads of patients with Alzheimer's disease and primary caregivers have been followed up for 1 year to evaluate cognitive (Mini-Mental State Examination), functional (Instrumental Activities of Daily Living), and behavioral (Neuropsychiatric Inventory) decline of patient in relation to burden (Caregiver Burden Inventory), stress (Relative Stress Scale), anxiety (State-Trait Anxiety Inventory Y), and depression (Beck Depression Inventory) reported by the caregivers. After 1 year of observation, cognitive and functional scores worsened while behavioral problems remained unchanged and relatively mild in patients. After 1 year, caregivers' scores of scales of anxiety and depression decreased significantly, while stress scores remained unchanged and burden slightly increased. Read More

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http://dx.doi.org/10.1177/1533317519899544DOI Listing
February 2020

Disclosure of Amyloid Status for Risk of Alzheimer Disease to Cognitively Normal Research Participants With Subjective Cognitive Decline: A Longitudinal Study.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520904551

Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.

This study aimed to investigate the long-term impacts of disclosing amyloid status for a risk of Alzheimer disease (AD) to cognitively normal research participants with subjective cognitive decline (SCD), which represents an initial manifestation of AD. Forty-two participants were classified as the amyloid-positive ( = 10) or amyloid-negative ( = 32) groups. We assessed symptoms of anxiety, depression, and test-related distress at 6, 24, and 52 weeks after results disclosure. Read More

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http://dx.doi.org/10.1177/1533317520904551DOI Listing
February 2020

Determining Middle-Aged and Older Adults' Health Beliefs to Change Lifestyle and Health Behavior for Dementia Risk Reduction.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519898996

Department of Internal Medicine Nursing, Dokuz Eylul University Faculty of Nursing, Inciralti, Izmir, Turkey.

Background: Global population is getting older and the prevalence of dementia continuously increases. Understanding the related health beliefs is bound to enable lifestyle-based interventions that maximize public engagement in dementia risk reduction behaviors. The aim of this study was to determine health beliefs on dementia prevention behaviors and lifestyle changes and to determine the factors influencing these beliefs among middle-aged and older people in Turkey. Read More

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http://dx.doi.org/10.1177/1533317519898996DOI Listing
February 2020

Reduction of Amyloid in the Brain and Retina After Treatment With IVIG for Mild Cognitive Impairment.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519899800

Sutter Neuroscience Institute, Sacramento, CA, USA.

Objective: To assess whether intravenous immunoglobulin (IVIG) in subjects with mild cognitive impairment (MCI) results in a reduction in amyloid in the central nervous system (CNS).

Methods: Five subjects with MCI underwent baseline Florbetapir positron emission tomography and retinal autofluorescent imaging. All were administered IVIG (Octagam 10%) at 0. Read More

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http://dx.doi.org/10.1177/1533317519899800DOI Listing
February 2020

Effect of Self-Efficacy on Quality of Life in People With Mild Cognitive Impairment and Mild Dementia: The Mediating Roles of Depression and Anxiety.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519885264

Department of Geriatric Medicine, Oslo University Hospital, Ullevål, Norway.

Objectives: To examine the mediating effects of depression and anxiety in the relationship between self-efficacy and quality of life among people with mild cognitive impairment (MCI) or mild dementia.

Method: A total of 196 patients diagnosed with MCI or dementia due to Alzheimer disease completed structured measures of self-efficacy, quality of life, and depressive and anxiety symptoms. We examined direct and mediated effects by fitting structural equation models to data. Read More

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http://dx.doi.org/10.1177/1533317519885264DOI Listing
January 2020

Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519896725

Shanghai University of Sport, Shanghai, China.

Although intermittent hypoxia training (IHT) has proven effective against various clinical disorders, its impact on mild cognitive impairment (MCI) is unknown. This pilot study examined IHT's safety and therapeutic efficacy in elderly patients with amnestic MCI (aMCI). Seven patients with aMCI (age 69 ± 3 years) alternately breathed 10% O and room-air, each 5 minutes, for 8 cycles/session, 3 sessions/wk for 8 weeks. Read More

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http://dx.doi.org/10.1177/1533317519896725DOI Listing
January 2020

The Turkish Version of the Telephone Cognitive Screen for Detecting Cognitive Impairment in Older Adults.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519889810. Epub 2019 Nov 22.

Department of Internal Medicine, Gulhane Faculty of Medicine & Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

The ability to screen Turkish-speaking older adults for cognitive impairment by phone is lacking. The aim of this study was to translate the existing version of the telephone cognitive screen (T-CogS) into Turkish version (T-CogS-TR) and evaluate its reliability and validity in community-dwelling older adults. We prospectively recruited 104 community-dwelling participants with mild to moderate Alzheimer's disease (AD) and healthy controls. Read More

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http://dx.doi.org/10.1177/1533317519889810DOI Listing
November 2019

Comparison of Urinary Alzheimer-Associated Neural Thread Protein (AD7c-NTP) Levels Between Patients With Amnestic and Nonamnestic Mild Cognitive Impairment.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519880369. Epub 2019 Nov 18.

Department of Neurology, Chonbuk National University Hospital, Chonbuk National University School of Medicine, Jeonju, South Korea.

Urinary Alzheimer-associated neural thread protein (AD7c-NTP) is a potential biomarker of Alzheimer disease (AD) or mild cognitive impairment (MCI). It is still unclear whether the urinary levels of AD7c-NTP are different between patients with amnestic MCI (aMCI) and nonamnestic MCI (naMCI). The present study aimed to explore the differences in urinary levels of AD7c-NTP between patients with aMCI and naMCI. Read More

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http://dx.doi.org/10.1177/1533317519880369DOI Listing
November 2019
1.426 Impact Factor

Experiences of Living With Primary Progressive Aphasia: A Scoping Review of Qualitative Studies.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519886218. Epub 2019 Nov 6.

School of Audiology and Speech Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

Introduction: Understanding the experiences of people who live with primary progressive aphasia (PPA) can inform the development of appropriate speech-language pathology services for this population. This review aimed to summarize the qualitative research on the experience of living with PPA from the perspective of the individuals with the disorder and their families.

Methods: A scoping review was conducted. Read More

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http://dx.doi.org/10.1177/1533317519886218DOI Listing
November 2019

Horticultural Therapy in Patients With Dementia: A Systematic Review and Meta-Analysis.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519883498. Epub 2019 Nov 5.

Department of Post-Baccalaureate Veterinary Medicine, Asia University, Wufeng District, Taichung City.

Background: World Health Organization has communicated that dementia as a public health priority in 2012. Behavioral and psychological symptoms of dementia are the main reason results in hospitalization of dementia patients. Horticulture is one of the favorite activity for many peoples to relax their minds. Read More

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http://dx.doi.org/10.1177/1533317519883498DOI Listing
November 2019

Factors Affecting Caregivers' Acceptance of the Use of Wearable Devices by Patients With Dementia: An Extension of the Unified Theory of Acceptance and Use of Technology Model.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519883493. Epub 2019 Nov 3.

Statistics Department, Tamale Technical University, Tamale, Ghana.

Purpose: This study aims to examine the factors affecting caregivers' acceptance of the use of wearable devices by patients with dementia by extending the Unified Theory of Acceptance and Use of Technology (UTAUT) model with 2 additional constructs: resistance to change (RC) and technology anxiety (TA).

Methods: A structured online questionnaire was developed and distributed to caregivers who have either dealt previously with or were currently taking care of patients with dementia in sub-Saharan Africa. The selection of countries for the study was purely based on the availability of caregivers of patients with dementia and their readiness to take part in the survey. Read More

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http://dx.doi.org/10.1177/1533317519883493DOI Listing
November 2019

β-Hydroxybutyrate Ameliorates Aβ-Induced Downregulation of TrkA Expression by Inhibiting HDAC1/3 in SH-SY5Y Cells.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519883496. Epub 2019 Oct 24.

Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China.

Tyrosine kinase receptor A (TrkA) plays an important role in the protection of cholinergic neurons in Alzheimer's disease (AD). This study was designed to investigate whether β-hydroxybutyrate (BHB), an endogenous histone deacetylase (HDAC) inhibitor, upregulates the expression of TrkA by affecting histone acetylation in SH-SY5Y cells treated with amyloid β-protein (Aβ). The results showed that BHB ameliorated the reduction of cell vitality and downregulation of TrkA expression induced by Aβ. Read More

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http://dx.doi.org/10.1177/1533317519883496DOI Listing
October 2019

Physical Activity in Severe Dementia Is Associated With Agitation Rather Than Cognitive Function.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519871397. Epub 2019 Sep 18.

Course of Comprehensive Rehabilitation, Osaka Prefecture University Graduate School, Habikino-City, Osaka, Japan.

Background: The authors examined associations between physical activity, cognitive function, activities of daily living, and behavioral and psychological dementia symptoms (BPSD) in severe and moderate dementia.

Methods: A cross-sectional study was conducted to assess severe and moderate dementia groups according to the Clinical Dementia Rating. An actigraphy measured physical activity. Read More

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http://dx.doi.org/10.1177/1533317519871397DOI Listing
September 2019
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Feasibility of Conducting Nonpharmacological Interventions to Manage Dementia Symptoms in Community-Dwelling Older Adults: A Cluster Randomized Controlled Trial.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519872635. Epub 2019 Sep 18.

Comprehensive Center for Brain Health, Charles E. Schmidt College of Medicine, Boca Raton, FL, USA.

This study assessed the feasibility of conducting 3 nonpharmacological interventions with older adults in dementia, exploring the effects of chair yoga (CY), compared to music intervention (MI) and chair-based exercise (CBE) in this population. Using a cluster randomized controlled trial (RCT), 3 community sites were randomly assigned 1:1:1 to CY, MI, or CBE. Participants attended twice-weekly 45-minute sessions for 12 weeks. Read More

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http://dx.doi.org/10.1177/1533317519872635DOI Listing
September 2019

Gender Differences in the Association Between Hearing Loss and Cognitive Function.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519871167. Epub 2019 Sep 11.

Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: This study aimed to determine the association between hearing loss and cognitive function by gender in a nationally representative sample of older adults.

Methods: We used data from the National Health and Nutrition Examination Survey (2010-2011) for 655 participants aged 60 to 69 years. The cognitive functioning component consisted of the Consortium to Establish a Registry for Alzheimer's disease, the Animal Fluency Test, and the Digit Symbol Substitution Test. Read More

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http://dx.doi.org/10.1177/1533317519871167DOI Listing
September 2019

Validation of the RUDAS in Patients With a Middle-Level Education in Lima, Peru.

Am J Alzheimers Dis Other Demen 2019 Nov-Dec;34(7-8):513-522. Epub 2019 Aug 18.

Servicio de Neurología, Instituto Peruano de Neurociencias, Lima, Peru.

Objectives: To assess the psychometric properties of the Peruvian version of the Rowland Universal Dementia Assessment Scale (RUDAS-PE) to discriminate controls from patients with mild cognitive impairment (MCI) and early dementia (ED) in a population with a mid-level education.

Methods: A total of 133 patients from a memory clinic were administered the RUDAS-PE, INECO Frontal Screening, Addenbrooke's Cognitive Examination, and Mini-Mental State Examination. Results were compared against a neuropsychological evaluation (gold standard). Read More

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http://dx.doi.org/10.1177/1533317519869709DOI Listing
August 2019
2 Reads

Cerebrospinal Fluid, Imaging, and Physiological Biomarkers in Dementia With Lewy Bodies.

Am J Alzheimers Dis Other Demen 2019 Nov-Dec;34(7-8):421-432. Epub 2019 Aug 18.

Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Dementia with Lewy bodies is a progressive neurodegenerative disorder, clinically characterized by gradual cognitive impairment and fluctuating cognition, behavioral changes and recurrent visual hallucinations, and autonomic function and movement symptoms in the type of parkinsonism. It is the second most common type of dementia in the Western world after Alzheimer disease. Over the last 20 years, many neurophysiological, neuroimaging, and cerebrospinal fluid (CSF) biomarkers have been described toward a better discrimination between dementia with Lewy bodies, Alzheimer disease, and other neurodegenerative conditions. Read More

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http://dx.doi.org/10.1177/1533317519869700DOI Listing
August 2019
1 Read

Impact of Zumba on Cognition and Quality of Life is Independent of APOE4 Carrier Status in Cognitively Unimpaired Older Women: A 6-Month Randomized Controlled Pilot Study.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519868370. Epub 2019 Aug 11.

Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.

Objective: To investigate the association of a 6-month Zumba intervention with cognition and quality of life among older cognitively unimpaired apolipoprotein ∊4 (APOE4) carrier and noncarrier women.

Methods: Fifty-three women were randomly assigned to either twice-weekly Zumba group classes or maintenance of habitual exercise (control group) for 6 months. At baseline, 3, and 6 months, all participants underwent neuropsychological, physical activity, and quality-of-life assessments. Read More

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http://dx.doi.org/10.1177/1533317519868370DOI Listing
August 2019
1 Read

An Experimental Pilot Study of Global Postural Reeducation Concerning the Cognitive Approach of Patients With Alzheimer's Disease.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519867824. Epub 2019 Aug 8.

Hospital University Virgen de Arrixaca (HUVA), Murcia, Spain.

Background: Several recent studies have examined the positive effects of physical exercise and equilibrium on individuals with neurodegenerative diseases.

Objectives: In this sense, this study based on an experimental design, tested whether global postural reeducation (GPR) can affect equilibrium and cognition, life quality, and psychological symptoms of patients with Alzheimer's disease (AD).

Methods: One hundred thirty-five participants with mild and moderate AD diagnosis were assigned to 2 groups: experimental group (EG, n = 90) and control group (CG, n = 45). Read More

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http://dx.doi.org/10.1177/1533317519867824DOI Listing
August 2019
2 Reads

Adapting the Resilience Framework for Family Caregivers of Hospice Patients With Dementia.

Am J Alzheimers Dis Other Demen 2019 09;34(6):399-411

6 School of Nursing, University of Pennsylvania, Philadelphia, PA, USA.

Family caregivers face ongoing, formidable stress and burden. Caregivers need sustainable support to maintain resilience. We aim to identify challenges, possible solutions that are resources for resilience, and expected consequences from the perspective of 39 family caregivers of hospice patients with dementia. Read More

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http://dx.doi.org/10.1177/1533317519862095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179812PMC
September 2019

Association Between Individual Components of Metabolic Syndrome and Cognitive Function in Northeast Rural China.

Am J Alzheimers Dis Other Demen 2019 Nov-Dec;34(7-8):507-512. Epub 2019 Jul 28.

Program of Environmental Physical Factors and Health, School of Public Health, China Medical University, Shenyang, China.

Aim: The aim of this article was to examine associations between metabolic syndrome and its individual components with cognitive function among rural elderly population in northeast China.

Methods: Our study included 1047 residents aged older than 60 years in a northeast rural area. All were interviewed and data were obtained including sociodemographic and medical histories. Read More

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http://dx.doi.org/10.1177/1533317519865428DOI Listing
July 2019
2 Reads

The Quality of Interactions Between Staff and Residents With Cognitive Impairment in Nursing Homes.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519863259. Epub 2019 Jul 21.

University of Maryland School of Nursing, Baltimore, MD, USA.

Background: Positive and effective staff-resident interactions are imperative to adequately assess and meet the needs of cognitively impaired residents in nursing homes and optimize their quality of life.

Aim: The purpose of this study was to quantify, describe, and analyze the interaction between staff and cognitively impaired residents in nursing homes, using the Quality of Interaction Schedule (QuIS).

Method: This descriptive analysis utilized baseline data from the first 2 cohorts in a randomized clinical trial including 341 residents from 35 nursing homes. Read More

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http://dx.doi.org/10.1177/1533317519863259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980162PMC

Decreased Levels of Serum IGF-1 and Vitamin D Are Associated With Cognitive Impairment in Patients With Type 2 Diabetes.

Am J Alzheimers Dis Other Demen 2019 Nov-Dec;34(7-8):450-456. Epub 2019 Jul 18.

Department of Endocrinology, Shanghai Pudong New Area People's Hospital, Shanghai, China.

Purpose: To determine the association of serum insulin-like growth factor 1 (IGF-1) and vitamin D levels with cognition status in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 173 patients with T2DM were recruited and divided into mild cognitive impairment (MCI) group (n = 94) and normal cognition (NC) group (n = 79). Levels of IGF-1 and 25(OH)D were measured and compared, and the correlations among IGF-1, 25(OH)D, and cognitive function were analyzed. Read More

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http://dx.doi.org/10.1177/1533317519860334DOI Listing
July 2019
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Biosignals to Detect the Imbalance of Explicit and Implicit Affect in Dementia: A Pilot Study.

Am J Alzheimers Dis Other Demen 2019 Nov-Dec;34(7-8):457-463. Epub 2019 Jul 17.

Department of Psychiatry, Eun-Hye Hospital, Incheon, South Korea.

Background: We assessed implicit and explicit emotion in older patients with dementia using biosignals.

Methods: Fifty patients with dementia and 34 healthy individuals watched 3 videos that aimed to elicit various emotional responses. Electroencephalogram and heart rate variability were recorded. Read More

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http://dx.doi.org/10.1177/1533317519863579DOI Listing
July 2019
3 Reads

Age-Related Effect of Antihypertensive Treatment on Cognitive Performance: Is it Better Preventing Dementia in Older Age?

Am J Alzheimers Dis Other Demen 2019 Nov-Dec;34(7-8):486-491. Epub 2019 Jul 17.

Faculty of Medicine, Islamic Azad University Mashhad Branch, Mashhad, Iran.

The aim of this study is to investigate the impact of optimal antihypertensive medication on cognitive function. In this 6-month clinical trial, 248 adults were randomly selected by a registry of hypertensive-treated patients (based on a National Hypertension Treatment Program), followed health centers located in Rafsanjan County, Southeast, Iran. Blood pressure was measured 3 times in each appointment pre- and posttreatment. Read More

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http://dx.doi.org/10.1177/1533317519859197DOI Listing
July 2019
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Treatment Indications in Clinical Practice and Applied Research on Psychosocial Interventions for People With Dementia.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519859213. Epub 2019 Jul 17.

University of the French West Indies, Faculty of Medicine, Martinique, France.

A recent review of Cochrane meta-analyses on psychosocial interventions (PIs) concludes that clinical trials fail to confirm PIs effective for all types of dementia at every stage of the disease. This article describes how and to what extent it is necessary to identify treatment indications when researching PIs and employing them in clinical practice. Twelve Cochrane reviews on PIs for people with dementia, selected because of their systematic methodology, were searched to identify outcomes related to treatment indications (dosage, type of dementia, severity…). Read More

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http://dx.doi.org/10.1177/1533317519859213DOI Listing

Investigation of the Effects of Biochemical Parameters on Alzheimer's Disease.

Am J Alzheimers Dis Other Demen 2019 Nov-Dec;34(7-8):464-468. Epub 2019 Jul 16.

Department of Neurology, Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.

Background: The most common type of dementia is an Alzheimer's disease which is a major concern in growing chronic diseases in the geriatric society, and its connection with biochemistry has not been sufficiently understood.

Objective: This study aims to evaluate the effects of blood biochemistry on Alzheimer's disease.

Method: Eight participants aged 55+ with Alzheimer's disease were analyzed. Read More

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http://dx.doi.org/10.1177/1533317519862108DOI Listing

The Effects of Intuitive Movement Reembodiment on the Quality of Life of Older Adults With Dementia: A Pilot Study.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519860331. Epub 2019 Jul 14.

Department of Dance, School of Physical Education, Sport and Exercise Sciences, University of Otago, Dunedin, New Zealand.

Background: The creative use of reminiscent music and natural movements were reported to have positive effects on the well-being of older adults with cognitive impairment.

Objectives: To explore the effects of the intuitive movement reembodiment (IMR) program on the quality of life (QoL) of older adults with dementia.

Methods: Data collected from 22 participants were analyzed: group 1 (mild dementia), group 2 (moderate dementia), group 3 (advanced dementia). Read More

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http://dx.doi.org/10.1177/1533317519860331DOI Listing
July 2019
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Immediate Benefit of Art on Pain and Well-Being in Community-Dwelling Patients with Mild Alzheimer's.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317519859202. Epub 2019 Jul 9.

Neurology Unit, CM2R, University Hospital of Saint-Etienne, Saint-Etienne, France.

Objective: The present report aims to evaluate whether singing intervention can bring an immediate benefit that is greater than the one provided by painting intervention on pain and well-being.

Methods: Fifty-nine mild patients with Alzheimer disease were randomized to a 12-week singing (n = 31) or painting group (n = 28). In the present analysis, the immediate evolution of pain and well-being was compared across sessions between the 2 groups using mixed-effects models. Read More

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http://dx.doi.org/10.1177/1533317519859202DOI Listing
July 2019
2 Reads

The Efficacy of General Practitioner Assessment of Cognition in Chinese Elders Aged 80 and Older.

Am J Alzheimers Dis Other Demen 2019 Nov-Dec;34(7-8):523-529. Epub 2019 Jul 2.

Wuhan Union Hospital, Neurology Wuhan Union Hospital, Hankou District, Wuhan, Hubei, China.

Objectives: This study examined the efficacy of the General Practitioner Assessment of Cognition-Chinese version (GPCOG-C) in screening dementia and mild cognitive impairment (MCI) among older Chinese.

Methods: Survey questionnaires were administered to 293 participants aged 80 or above from a university hospital in mainland China. Alzheimer disease and MCI were diagnosed in light of the National Institute on Aging and the Alzheimer's Association (NIA/AA) criteria. Read More

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http://dx.doi.org/10.1177/1533317519860333DOI Listing
July 2019
3 Reads
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Purkinje Cells Pathology in Alzheimer's Disease.

Am J Alzheimers Dis Other Demen 2019 Nov-Dec;34(7-8):439-449. Epub 2019 Jun 30.

Laboratory of Neuropathology and Electron Microscopy Thessaloniki, School of Medicine, Aristotle University of Thessaloniki, Greece.

Alzheimer's disease (AD) is one of the main causes of dementia in senium and presenium. It is clinically characterized by memory impairment, deterioration of intellectual faculties, and loss of professional skills. The cerebellum is a critical part in the distributed neural circuits participating not only in motor function but also in autonomic, limbic, and cognitive behaviors. Read More

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http://dx.doi.org/10.1177/1533317519859200DOI Listing
June 2019
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Apathy and Disinhibition Related to Neuropathology in Amnestic Versus Behavioral Dementias.

Am J Alzheimers Dis Other Demen 2019 08 6;34(5):337-343. Epub 2019 Jun 6.

1 Cognitive Neurology and Alzheimer's Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Objectives: Investigating the frequency of apathy and disinhibition in patients clinically diagnosed with dementia of the Alzheimer type (DAT) or behavioral variant frontotemporal dementia (bvFTD) with neuropathology of either Alzheimer disease (AD) or frontotemporal lobar degeneration (FTLD).

Methods: Retrospective data from 887 cases were analyzed, and the frequencies of apathy and disinhibition were compared at baseline and longitudinally in 4 groups: DAT/AD, DAT/FTLD, bvFTD/FTLD, and bvFTD/AD.

Results: Apathy alone was more common in AD (33%) than FTLD (25%), and the combination of apathy and disinhibition was more common in FTLD (43%) than AD (14%; < . Read More

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http://journals.sagepub.com/doi/10.1177/1533317519853466
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http://dx.doi.org/10.1177/1533317519853466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256964PMC
August 2019
9 Reads

Cerebrovascular Disease Is a Risk for Getting Lost Behavior in Prodromal Dementia.

Am J Alzheimers Dis Other Demen 2019 08 29;34(5):344-352. Epub 2019 May 29.

1 Department of Neurology, National Neuroscience Institute, Singapore, Singapore.

Cerebrovascular disease (CVD) contributes to spatial navigation deficits; however, the everyday outcomes of this association remain unexplored. We investigated whether CVD was a risk for getting lost behavior (GLB) in elderly with mild cognitive impairment (MCI) and mild Alzheimer disease (AD). Getting lost behavior was assessed using a semistructured clinical interview and was associated with white matter lesions (WMLs) in patients with MCI. Read More

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http://dx.doi.org/10.1177/1533317519852864DOI Listing
August 2019
16 Reads

Effect of Different Sources Support on Adaptation in Families of Patient With Moderate-to-Severe Dementia in China.

Am J Alzheimers Dis Other Demen 2019 09 29;34(6):361-375. Epub 2019 May 29.

1 Department of Fundamental Nursing, School of Nursing, Peking Union Medical College, Beijing, China.

Purpose: To examine the support from different sources of Chinese families of patients with moderate-to-severe dementia that most heavily influences the family adaptation and the influence pathway.

Method: Two hundred and three families participated in this study. Chinese versions of instruments were used. Read More

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http://dx.doi.org/10.1177/1533317519855154DOI Listing
September 2019
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A Comparative Study on the Memory-Enhancing Actions of Oral Renin-Angiotensin System Altering Drugs in Scopolamine-Treated Mice.

Am J Alzheimers Dis Other Demen 2019 08 19;34(5):329-336. Epub 2019 May 19.

1 Pharmacodynamics and Clinical Pharmacy Department, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania.

This study was designed to evaluate the spatial working memory (as studied in Y-maze) or short-term and long-term spatial memory (assessed in radial 8 arms-maze task), in a scopolamine-induced memory deficits model in mice, by the oral administration of 2 angiotensin-converting enzyme inhibitors-captopril and ramipril and also the effects of the AT1 receptor antagonist, losartan. The present article was initiated as a reaction to the clinical setting of hypertensive disease, which involves lifelong administration of antihypertensive drugs, dietary or lifestyle constraints, and aging, which all take a toll on the higher functions of the nervous system. Most of the patients with cognitive decline suffer of various metabolic imbalances, hypertension, cardiac and kidney disease, many of them which are treated with oral administration of Renin-angiotensin aldosterone system-altering agents like those presented above. Read More

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http://dx.doi.org/10.1177/1533317519847042DOI Listing
August 2019
7 Reads