371,924 results match your criteria American journal of Alzheimer's disease Columbia Mo.[Journal]


Implementing the Behavioral and Mental Health Entrustable Professional Activity: Insights for a Path Forward.

Acad Pediatr 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center (CCHMC), 3333 Burnet Ave, ML 2008, Cincinnati, OH 45229; Division of Emergency Medicine, CCHMC, 3333 Burnet Ave, ML 2008, Cincinnati, OH 45229. Electronic address:

Introduction: Mental health problems in children and youth are growing exponentially. General pediatricians, while in a unique position to address these issues as they arise, report they lack adequate training in assessing and managing behavioral/mental health (B/MH) problems. Underscoring the importance of this area, the American Board of Pediatrics has defined B/MH as one of only 17 foundational entrustable professional activities (EPAs) for general pediatric practice. Read More

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http://dx.doi.org/10.1016/j.acap.2020.07.002DOI Listing

Cold agglutinin disease and autoimmune hemolytic anemia with pulmonary embolism as a presentation of COVID-19 infection.

Hematol Oncol Stem Cell Ther 2020 Jul 6. Epub 2020 Jul 6.

Division of Hematology and Oncology, Department of Internal Medicine, Henry Ford Health System, Wayne State University, Detroit, MI, USA.

Background: Lymphopenia, thrombocytopenia, and elevated D-dimer and ferritin levels are frequently reported in patients with severe coronavirus disease 2019 (COVID-19). Here we report a case of cold agglutinin disease (CAD), autoimmune hemolytic anemia (AIHA), and pulmonary embolism as a presentation of COVID-19 infection.

Case Report: A 51-year-old African-American woman presented to the emergency room with fever and shortness of breath. Read More

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http://dx.doi.org/10.1016/j.hemonc.2020.06.005DOI Listing

Response surface optimization of phenolic compounds extraction from camu-camu (Myrciaria dubia) seed coat based on chemical properties and bioactivity.

J Food Sci 2020 Jul 9. Epub 2020 Jul 9.

Department of Food Engineering, State University of Ponta Grossa, Ponta Grossa, Brazil.

Food companies should comply with the requirements of a zero-waste concept to adapt to the circular economy requirements. In fruit companies, usually seeds are discarded without proper utilization and extraction of the bioactive compounds. Fruit seeds are sources of chemical compounds that can be extracted, studied, and applied in high value-added products. Read More

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http://dx.doi.org/10.1111/1750-3841.15327DOI Listing

CAR T-Cell Therapy Shows Promise in Multiple Hematologic Malignancies.

Authors:
Kristie L Kahl

Oncology (Williston Park) 2020 Jan;34(1):20

Multiple studies designed to evaluate chimeric antigen receptor (CAR) T-cell therapies in various hematologic malignancies appeared to show promise at the 61st American Society of Hematology (ASH) Annual Meeting and Exposition in Orlando, Florida. Read More

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January 2020

An Evaluation of Baseline Kidney Function in the REPRIEVE Trial of Pitavastatin in Human Immunodeficiency Virus.

J Infect Dis 2020 Jul;222(Supplement_1):S41-S51

Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.

Background: Chronic kidney disease is a common comorbid condition among persons living with human immunodeficiency virus (PWH). We characterized baseline kidney function in the REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) trial cohort.

Methods: REPRIEVE enrolled PWH with low to moderate cardiovascular risk based on traditional risk factors to evaluate the effect of statin therapy on cardiovascular events. Read More

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http://dx.doi.org/10.1093/infdis/jiaa222DOI Listing

Patterns of Antiretroviral Therapy Use and Immunologic Profiles at Enrollment in the REPRIEVE Trial.

J Infect Dis 2020 Jul;222(Supplement_1):S8-S19

Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: Patterns of antiretroviral therapy (ART) use and immunologic correlates vary globally, and contemporary trends are not well described.

Methods: The REPRIEVE trial (Randomized Trial to Prevent Vascular Events in HIV) enrolled persons with human immunodeficiency virus (HIV) who were aged 40-75 years, receiving ART, and had low-to-moderate cardiovascular disease risk. ART use was summarized within Global Burden of Disease (GBD) super-regions, with adjusted linear and logistic regression analyses examining associations with immune parameters and key demographics. Read More

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http://dx.doi.org/10.1093/infdis/jiaa259DOI Listing

HIV antiretroviral therapy and prevention use in US blood donors: A new blood safety concern.

Blood 2020 Jul 9. Epub 2020 Jul 9.

Department of Laboratory Medicine, UCSF, United States.

Context: Antiretroviral therapy (ART) to treat and pre-exposure prophylaxis (PrEP) to prevent HIV infection are effective tools to help end the HIV epidemic. However, their use could affect HIV transfusion-transmission risk.

Objectives: Three different ART/PrEP prevalence analyses in blood donors were conducted. Read More

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http://dx.doi.org/10.1182/blood.2020006890DOI Listing

Private patient rooms and hospital-acquired methicillin-resistant Staphylococcus aureus: A hospital-level analysis of administrative data from the United States.

PLoS One 2020 9;15(7):e0235754. Epub 2020 Jul 9.

Department of Rehabilitation and Health Services, College of Health and Public Service, University of North Texas, Denton, Texas, United States of America.

Objective: To use hospital-level data from the US to determine whether private patient rooms (PPRs) are associated with fewer in hospital-acquired methicillin-resistant Staphylococcus aureus (HA-MRSA) infections.

Methods: We retrospectively analyzed Texas Inpatient Public Use Data with discharges between September 2015 and August 2016 merged with American Hospital Association annual survey data. We used negative binomial regression to estimate the association between the proportion of PPRs within a hospital and the count of discharges with HA-MRSA infections, adjusting for potentially confounding variables. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235754PLOS

Mapping the relationships between joint stiffness, modeled muscle stiffness, and shear wave velocity.

J Appl Physiol (1985) 2020 Jul 9. Epub 2020 Jul 9.

Department of Physical Therapy and Human Movement Sciences, Northwestern University, United States.

Joint stiffness is often measured to make inferences about the stiffness of muscle groups, but little can be gleaned about individual muscles. Decomposing the muscular origins of joint stiffness may inform treatment targets for conditions like spasticity. To complement joint stiffness, shear wave ultrasound elastography has been used to estimate the material properties of individual muscles. Read More

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http://dx.doi.org/10.1152/japplphysiol.00133.2020DOI Listing

The Association Between Early Age-Related Hearing Loss and Brain β-Amyloid.

Laryngoscope 2020 Jul 9. Epub 2020 Jul 9.

Department of Medicine, Columbia University, New York, New York, U.S.A.

Objectives/hypothesis: To analyze the association between early audiometric age-related hearing loss and brain β-amyloid, the pathologic hallmark of Alzheimer's disease (AD).

Study Design: Cross-sectional analysis of a prospective cohort study.

Methods: A cross-sectional analysis was performed on 98 participants in a cohort study of hearing and brain biomarkers of AD. Read More

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http://dx.doi.org/10.1002/lary.28859DOI Listing

Control of blood pressure levels in patients with premature coronary artery disease: Results from the Genetics of Atherosclerotic Disease study.

J Clin Hypertens (Greenwich) 2020 Jul 9. Epub 2020 Jul 9.

Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

High blood pressure (BP) is the major cardiovascular-risk factor for coronary artery disease (CAD), principally in young patients who have an important and increasing socioeconomic burden. Despite the Seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7), recommended BP target <140/90 mm Hg for patients with stable CAD, in 2017 the American College of Cardiology and the American Heart Association (ACC/AHA) updated BP target to <130/80 mm Hg. We aimed to analyze the prevalence of BP control in patients with premature CAD using both criteria. Read More

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http://dx.doi.org/10.1111/jch.13942DOI Listing

'Candidatus Mycoplasma haemoalbiventris', a novel hemoplasma species in white-eared opossums (Didelphis albiventris) from Brazil.

Transbound Emerg Dis 2020 Jul 9. Epub 2020 Jul 9.

Department of Veterinary Medicine, Universidade Federal do Paraná, Curitiba, PR, Brazil.

Opossums of the genus Didelphis are considered synanthropic animals due to their close contact with human beings. Previously, two species of hemotropic mycoplasmas (hemoplasmas) have been detected in opossums: 'Candidatus Mycoplasma haemodidelphidis' in the North American opossum (Didelphis virginiana) and a potentially novel hemotropic Mycoplasma sp. in the white-eared opossums (Didelphis albiventris) from Brazil. Read More

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http://dx.doi.org/10.1111/tbed.13716DOI Listing

Access and socioeconomic status play an important role in outcomes for African American patients with prostate cancer.

Cancer 2020 Jul 9. Epub 2020 Jul 9.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1002/cncr.33063DOI Listing

Managing Prostate Cancer Surgical Patients during the COVID-19 Pandemic: A Brief Report of the Duke Cancer Institute's Initial Experience.

Oncology (Williston Park) 2020 May;34(5):156-162

Division of Urology, Department of Surgery, Duke Cancer Institute, Duke University, Durham, NC.

The coronavirus disease 2019 pandemic has rapidly placed tremendous stress on health systems around the world. In response, multiple health systems have postponed elective surgeries in order to conserve hospital beds and personal protective equipment, minimize patient traffic, and prevent unnecessary utilization and exposure of healthcare workers. The American College of Surgeons released the following statement on March 13, 2020: "Each hospital, health system and surgeon should thoughtfully review all scheduled elective procedures with a plan to minimize, postpone, or cancel electively scheduled operations, endoscopes, or other invasive procedures until we have passed the predicted inflection point in the exposure graph and can be confident that our health care infrastructure can support a potentially rapid and overwhelming uptick in critical patient care needs. Read More

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Association of Independent Prognostic Factors and Treatment Modality With Survival and Recurrence Outcomes in Breast Cancer.

JAMA Netw Open 2020 Jul 1;3(7):e207213. Epub 2020 Jul 1.

National Clinical Target Validation Laboratory, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland.

Importance: It is not well understood whether prognostic factors in breast cancer are affected by specific treatment and vary by clinical outcome type compared with untreated patients.

Objective: To identify independent clinical and molecular measurements associated with overall survival (OS) and recurrence-free survival (RFS) by homogeneous treatment in women with breast cancer.

Design, Setting, And Participants: This prognostic study included 956 patients diagnosed with invasive breast cancer from hospital centers across 4 geographical regions of the United States who participated in the accreditation program of the Commission on Cancer of the American College of Surgeons from 1985 to 1997. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.7213DOI Listing

Associations between polycystic ovary syndrome and adverse obstetric and neonatal outcomes: a population study of 9.1 million births.

Hum Reprod 2020 Jul 9. Epub 2020 Jul 9.

Department of Obstetrics and Gynecology, McGill University Health Centre, McGill University, Montreal, QC, Canada.

Study Question: Does polycystic ovary syndrome (PCOS) confer an independent risk for adverse delivery and neonatal outcomes, based on analysis of the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) database?

Summary Answer: After controlling for all potential confounding effects, women with PCOS are at an increased risk of experiencing preterm pre-labour rupture of membranes (PPROM), pre-term delivery (PTD), placental abruption, caesarean section (C/S) delivery, chorioamnionitis and post-partum maternal infections.

What Is Known Already: PCOS may be associated with an increased risk of adverse perinatal outcomes. However, there remain significant gaps in understanding the correlation between PCOS and important delivery and neonatal complications. Read More

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http://dx.doi.org/10.1093/humrep/deaa144DOI Listing

Sociodemographic, ecological, and spatiotemporal factors associated with HIV drug resistance in Florida: a retrospective analysis.

J Infect Dis 2020 Jul 9. Epub 2020 Jul 9.

Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA.

Background: Persons living with HIV (PWH) with resistance to antiretroviral therapy (ART) are vulnerable to adverse HIV-related health outcomes and can contribute to transmission of HIV drug resistance (HIVDR) when non-virally suppressed. The degree to which HIVDR contributes to disease burden in Florida -the US state with the highest HIV incidence- is unknown.

Methods: We explored sociodemographic, ecological, and spatial-temporal associations of HIVDR. Read More

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http://dx.doi.org/10.1093/infdis/jiaa413DOI Listing

The ASPET Mentoring Network: Enhancing Diversity and Inclusion through Career Coaching Groups within a Scientific Society.

CBE Life Sci Educ 2020 Sep;19(3):ar29

Faculty Affairs, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.

Over the past decades, two persisting priorities in science, technology, engineering, and mathematics (STEM) training have been: 1) increasing the knowledge of and access to careers beyond academic scientist; and 2) increasing the diversity of the STEM workforce. Previous studies show that a uniquely constructed career coaching group provides strong support and progress for both priorities. This report extends this design into a more sustainable model that is positioned within the professional context of rising young scientists. Read More

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http://dx.doi.org/10.1187/cbe.19-10-0195DOI Listing
September 2020

Alveolar macrophage-derived extracellular vesicles inhibit endosomal fusion of influenza virus.

EMBO J 2020 Jul 9:e105057. Epub 2020 Jul 9.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

Alveolar macrophages (AMs) and epithelial cells (ECs) are the lone resident lung cells positioned to respond to pathogens at early stages of infection. Extracellular vesicles (EVs) are important vectors of paracrine signaling implicated in a range of (patho)physiologic contexts. Here we demonstrate that AMs, but not ECs, constitutively secrete paracrine activity localized to EVs which inhibits influenza infection of ECs in vitro and in vivo. Read More

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http://dx.doi.org/10.15252/embj.2020105057DOI Listing

Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR).

EMBO J 2020 Jul 9:e104730. Epub 2020 Jul 9.

Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.

The chimeric antigen receptor (CAR) directs T cells to target and kill specific cancer cells. Despite the success of CAR T therapy in clinics, the intracellular signaling pathways that lead to CAR T cell activation remain unclear. Using CD19 CAR as a model, we report that, similar to the endogenous T cell receptor (TCR), antigen engagement triggers the formation of CAR microclusters that transduce downstream signaling. Read More

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http://dx.doi.org/10.15252/embj.2020104730DOI Listing

Historical biogeography of Vochysiaceae reveals an unexpected perspective of plant evolution in the Neotropics.

Am J Bot 2020 Jul 9. Epub 2020 Jul 9.

Department of Integrative Biology, The University of Texas at Austin, 2415 Speedway no. C0930, Austin, Texas, 78712, USA.

Premise: Despite the fast pace of exploration of the patterns and processes influencing Neotropical plant hyperdiversity, the taxa explored are mostly from large groups that are widely distributed, morphologically diverse, or economically important. Vochysiaceae is an example of an undersampled taxon, providing an excellent system for investigating Neotropical biogeography. We present a phylogenomics-based hypothesis of species relationships in Vochysiaceae to investigate its evolutionary history through space and time. Read More

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http://dx.doi.org/10.1002/ajb2.1502DOI Listing

Atypical Cells on Reflectance Confocal Microscopy May Not Represent Melanoma: A Case of Axillary Pigmented Extramammary Paget Disease.

J Cutan Pathol 2020 Jul 9. Epub 2020 Jul 9.

Center for Dermatology, Rutgers Robert Wood Johnson Medical School, 1 Worlds Fair Drive, Somerset, New Jersey.

Pigmented extramammary Paget disease (PEMPD) is a rare intraepithelial carcinoma which can clinically resemble other pigmented neoplasms. Similarities to melanoma on dermoscopy, histopathology, and reflectance confocal microscopy (RCM) increase the risk of misdiagnosis, and consequently, mismanagement. Here, we describe a case of a 67-year-old African American woman with a large, pigmented axillary patch that contained features of melanoma on RCM, guiding the clinician to perform an excisional biopsy. Read More

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http://dx.doi.org/10.1111/cup.13804DOI Listing

Effect of Stellate Ganglion Block on Intraoperative Propofol and Fentanyl Consumption in Patients with Complex Regional Pain Syndrome Undergoing Surgical Repair of Brachial Plexus Injury: A Randomized, Double-blind, Placebo-controlled Trial.

Neurol India 2020 May-Jun;68(3):617-623

Department of Neuroanaesthesiology and Critical Care, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Stellate ganglion block (SGB) is commonly performed to treat chronic painful conditions, such as complex regional pain syndrome (CRPS) and postherpetic neuralgia. However, whether it is effective in reducing anesthesia and analgesia requirement during surgery (acute pain) is not known.

Materials And Methods: Sixty American Society of Anesthesiologists (ASA) physical status I and II patients with CRPS type II undergoing surgery for repair of brachial plexus injury were randomized (1:1) to receive SGB with either 10 mL of 0. Read More

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http://dx.doi.org/10.4103/0028-3886.288992DOI Listing

Patients with depression and anxiety symptoms from adjustment disorder related to their shoulder may be ideal patients for arthroscopic rotator cuff repair.

J Shoulder Elbow Surg 2020 Jul;29(7S):S80-S86

Department of Orthopaedic Surgery, Duke Sport Science Institute, Duke University Medical Center, Durham, NC, USA.

Background: Mood symptoms may be due to shoulder-related depression or anxiety or clinical anxiety/depression. The objective of this study was to evaluate the relationship of shoulder-related and pre-existing diagnosis of depression or anxiety with changes in American Shoulder and Elbow Surgeons (ASES) score after rotator cuff repair.

Methods: A retrospective review of prospectively collected data on subjects undergoing arthroscopic rotator cuff repair was reviewed. Read More

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http://dx.doi.org/10.1016/j.jse.2020.03.046DOI Listing

Arthroscopic supraglenoid origin-preserving biceps tenodesis: a reliable, simple, and cost-conscious technique.

J Shoulder Elbow Surg 2020 Jul;29(7S):S73-S79

Southern California Orthopedic Institute, Van Nuys, CA, USA.

Background: The purpose of this study was to assess the midterm clinical and ultrasonographic outcomes of a new all arthroscopic supraglenoid origin-preserving tenodesis technique of the long head of the biceps (LHB) brachii tendon in the setting of small to medium-sized rotator cuff repairs.

Materials And Methods: Thirty patients (33 shoulders) meeting inclusion criteria were identified who underwent LHB tenodesis with this technique in the setting of small to medium-sized rotator cuff repair at a mean age at surgery of 65.6 years between 2015 and 2017. Read More

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http://dx.doi.org/10.1016/j.jse.2020.03.013DOI Listing

Clinical characteristics and patient-reported outcomes of total shoulder arthroplasty after anterior stabilization: a retrospective matched control study.

J Shoulder Elbow Surg 2020 Jul;29(7S):S59-S66

The HSS Sports Medicine Institute, Hospital for Special Surgery, New York, NY, USA.

Background: Instability arthropathy is a known cause of glenohumeral osteoarthritis (OA) among patients with and without prior shoulder stabilization. This study aims to compare the clinical, radiographic, and patient-reported outcome measure (PROM) scores among total shoulder arthroplasty (TSA) patients with and without a history of shoulder stabilization.

Methods: A case-control study was performed comparing 20 patients with a history of anterior shoulder stabilization (11 open, 9 arthroscopic) who underwent TSA to a matched cohort of 20 TSA patients without a history of shoulder surgery (mean follow-up = 2. Read More

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http://dx.doi.org/10.1016/j.jse.2020.04.003DOI Listing

Minimal clinically important differences after subpectoral biceps tenodesis: definition and retrospective assessment of predictive factors.

J Shoulder Elbow Surg 2020 Jul;29(7S):S41-S47

Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD, USA. Electronic address:

Background: Minimal clinically important differences (MCIDs) at 1 year after subpectoral biceps tenodesis are unknown for the American Shoulder and Elbow Surgeons (ASES) scale, Subjective Shoulder Value (SSV), and visual analog scale (VAS) for pain. Our objectives were to determine MCIDs for these measures at 1 year after biceps tenodesis and to identify preoperative factors that predict attainment of MCIDs.

Methods: We included 52 patients who underwent arthroscopic débridement, decompression, and mini-open biceps tenodesis from 2016-2018. Read More

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http://dx.doi.org/10.1016/j.jse.2020.04.001DOI Listing

Early results of reverse total shoulder arthroplasty using a patient-matched glenoid implant for severe glenoid bone deficiency.

J Shoulder Elbow Surg 2020 Jul;29(7S):S139-S148

Department of Shoulder and Elbow Reconstruction, Cedars-Sinai Kerlan-Jobe Institute at Adventist Health White Memorial, Los Angeles, CA, USA.

Background: Reverse total shoulder arthroplasty (rTSA) in the presence of significant glenoid bone loss remains a challenge. This study presents preliminary clinical and radiographic outcomes of primary and revision rTSA using a patient-matched, 3-dimensionally printed custom metal glenoid implant to address severe glenoid bone deficiency.

Methods: Between September 2017 and November 2018, 19 patients with severe glenoid bone deficiency underwent primary (n = 9) or revision rTSA (n = 10) using the Comprehensive Vault Reconstruction System (VRS) (Zimmer Biomet, Warsaw, IN, USA) at a single institution. Read More

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http://dx.doi.org/10.1016/j.jse.2020.04.024DOI Listing

Salvage reverse total shoulder arthroplasty for failed anatomic total shoulder arthroplasty: a cohort analysis.

J Shoulder Elbow Surg 2020 Jul;29(7S):S134-S138

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA. Electronic address:

Background: Reverse total shoulder arthroplasty (RTSA) as a revision procedure for failed anatomic total shoulder arthroplasty (TSA) is increasing in incidence. The purpose of this study was to analyze the results of RTSA as a revision salvage procedure for failed TSA and identify factors that influenced those outcomes.

Methods: All anatomic TSAs that were revised to RTSAs in adult patients, under the care of 2 senior surgeons at a single academic center from 2006 to 2018, were queried and reviewed. Read More

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http://dx.doi.org/10.1016/j.jse.2020.04.013DOI Listing

A 10-year experience with reverse shoulder arthroplasty: are we operating earlier?

J Shoulder Elbow Surg 2020 Jul;29(7S):S126-S133

Department of Orthopedic Surgery, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Introduction: As surgeons' confidence in reverse shoulder arthroplasty (RSA) increases, they may tend to offer RSA earlier in the course of glenohumeral joint disease. This study evaluates the changes in the "tipping point" for primary RSA over a 10-year period to evaluate changes in practice.

Methods: A total of 3975 primary RSAs performed over a 10-year period were retrospectively reviewed from a multi-institutional database. Read More

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http://dx.doi.org/10.1016/j.jse.2020.04.040DOI Listing

Clinical and radiographic outcomes of a transosseous suture technique for displaced lateral clavicle fractures.

J Shoulder Elbow Surg 2020 Jul;29(7S):S101-S106

W.B. Carrell Memorial Clinic, Dallas, TX, USA.

Background: The purpose of this study was to evaluate the clinical and radiographic outcomes of a transosseous suture fixation technique for the treatment of unstable lateral clavicle fractures. The appropriate treatment for lateral clavicle fractures is controversial. Many authors have argued for nonsurgical treatment of these injuries; however, recent literature has shown a role for the surgical treatment of unstable fractures. Read More

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http://dx.doi.org/10.1016/j.jse.2020.04.041DOI Listing

Incidence of hypertension in obstructive sleep apnea using hypopneas defined by a 3 percent oxygen desaturation or arousal but not by only 4 percent oxygen desaturation.

J Clin Sleep Med 2020 Jul 9. Epub 2020 Jul 9.

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusettes.

Study Objectives: This analysis determined the ∼5 year incident hypertension rates using the 2018 American College of Cardiology/American Heart Association (ACC/AHA) blood pressure (BP) guidelines in obstructive sleep apnea (OSA) individuals with hypopneas defined by a ≥3% O₂ desaturation or arousal (3%A), but not by a hypopnea criterion of ≥4% (4% only).

Methods: Data were analyzed from Sleep Heart Health Study exam 2 participants (N=1219) who were normotensive (BP≤120/80 mm Hg) at exam 1. The apnea hypopnea index (AHI) at exam 1 was classified into 4 categories of OSA severity: <5, 5 ≤15, 15 ≤30 and ≥30/hour using both 3%A and 4% only definitions. Read More

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http://dx.doi.org/10.5664/jcsm.8684DOI Listing

Disease Salience Effects on Desire for Affiliation With In-Group and Out-Group Members: Cognitive and Affective Mediators.

Evol Psychol 2020 Jul-Sep;18(3):1474704920930700

University of Nevada, Las Vegas, NV, USA.

This study tested the hypothesis that threats related to infectious diseases would make persons less willing to affiliate with out-groups and that feelings of disgust and beliefs about the out-group members would mediate this effect. To test this hypothesis, American participants of European descent were presented with either a disease threat or control threat. Then they were shown a photograph of someone of the same race or different race. Read More

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http://dx.doi.org/10.1177/1474704920930700DOI Listing

Population genetics of wild Macaca fascicularis with low-coverage shotgun sequencing of museum specimens.

Am J Phys Anthropol 2020 Jul 8. Epub 2020 Jul 8.

University of Illinois Urbana-Champaign, Urbana, Illinois, USA.

Objectives: Long-tailed macaques (Macaca fascicularis) are widely distributed throughout the mainland and islands of Southeast Asia, making them a useful model for understanding the complex biogeographical history resulting from drastic changes in sea levels throughout the Pleistocene. Past studies based on mitochondrial genomes (mitogenomes) of long-tailed macaque museum specimens have traced their colonization patterns throughout the archipelago, but mitogenomes trace only the maternal history. Here, our objectives were to trace phylogeographic patterns of long-tailed macaques using low-coverage nuclear DNA (nDNA) data from museum specimens. Read More

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http://dx.doi.org/10.1002/ajpa.24099DOI Listing

Feasibility of Patient Navigation and Impact on Adherence to Screening Colonoscopy in a Large Diverse Urban Population.

J Racial Ethn Health Disparities 2020 Jul 8. Epub 2020 Jul 8.

Memorial Sloan Kettering Cancer Center, Department of Medicine, 1275 York Avenue, New York, NY, 10065, USA.

Introduction: Disparities observed in colorectal cancer (CRC) incidence and mortality among blacks and Hispanics compared with whites may be in part due to lower screening rates. The New York City (NYC) Department of Health and Mental Hygiene (DOHMH) has implemented a patient navigator (PN) program at NYC hospitals serving lower-income patients to promote high adherence by patients referred for screening colonoscopy. A prior study showed this PN program increased adherence at 3 public hospitals. Read More

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http://dx.doi.org/10.1007/s40615-020-00812-9DOI Listing

Comparison of thyroid hormone withdrawal and recombinant human thyroid-stimulating hormone administration for adjuvant therapy in patients with intermediate- to high-risk differentiated thyroid cancer.

Ann Nucl Med 2020 Jul 8. Epub 2020 Jul 8.

Department of Radiation Oncology and Image-applied Therapy, Kyoto University Graduate School of Medicine, 54, Shogoin Kawahara-cho, Sakyo-ku, Kyoto-shi, Kyoto, Japan.

Objective: To compare the clinical outcome in patients who received adjuvant therapy with radioactive iodine (RAI) using different preparation methods, namely, thyroid hormone withdrawal (THW) and recombinant human thyroid-stimulating hormone (rhTSH), after undergoing thyroidectomy for intermediate- to high-risk differentiated thyroid carcinoma (DTC) according to the American Thyroid Association criteria.

Methods: Between May 2012 and October 2018, 136 patients who underwent adjuvant therapy with high-dose (3700 MBq) RAI for DTC without any metastatic lesions or macroscopic residual lesions after surgical resection were retrospectively selected. Patients were excluded if distant metastasis was confirmed during adjuvant therapy or if the outcome could not be confirmed; thus, 112 patients were finally evaluated. Read More

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http://dx.doi.org/10.1007/s12149-020-01497-0DOI Listing

The effects of zinc on radiation-induced dysgeusia: a systematic review and meta-analysis.

Support Care Cancer 2020 Jul 8. Epub 2020 Jul 8.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Purpose: Many head and neck cancer patients who receive radiation therapy experience radiation-induced dysgeusia (RID), which has no standard treatment. The only supplement controlled clinical trials have evaluated for the treatment of RID is zinc. However, the results of these and other studies investigating the use of zinc for RID have been inconsistent. Read More

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http://dx.doi.org/10.1007/s00520-020-05578-8DOI Listing

Identifying Bright Spot Counties for Appropriate Diabetes Preventive Care: A Geospatial, Positive Deviance Approach.

J Prim Prev 2020 Jul 9. Epub 2020 Jul 9.

HealthLandscape, American Academy of Family Physicians, 3805 Edwards Road, Cincinnati, OH, 45209, USA.

Positive deviance approaches, which have been used to identify and study high performers (bright spots) and translate their successes to poorer performers, offer great potential for chronic disease management. However, there are few examples of applying positive deviance approaches across different geographic contexts. Building on prior research that developed a new measure for appropriate diabetes preventive care (DMPrevCare) and identified priority counties for this strategy, we introduce a geospatial approach for identifying bright spot counties and case matching them to priority counties that need improvement. Read More

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http://dx.doi.org/10.1007/s10935-020-00601-4DOI Listing

Acceptable outcomes with unicompartmental knee replacement and PCL deficiency are achievable: a case series of nine patients.

Knee Surg Sports Traumatol Arthrosc 2020 Jul 8. Epub 2020 Jul 8.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.

Purpose: Posterior cruciate ligament (PCL) deficiency is considered to be a contraindication for unicompartmental knee replacement (UKR); however, there is no evidence to support or contradict this. There are occasional circumstances where UKR in PCL deficient patients have been performed where the patient otherwise satisfies the indications for UKR. The aim of this paper is to describe the outcome of UKR in PCL deficient patients. Read More

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http://dx.doi.org/10.1007/s00167-020-06112-3DOI Listing

Ankle joint re-balancing in the management of ankle fracture malunion using fibular lengthening: prospective clinical-radiological results at mid-term follow-up.

Int Orthop 2020 Jul 8. Epub 2020 Jul 8.

II Clinic of Orthopaedics and Traumatology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Purpose: An unsatisfactory reduction and internal fixation of an ankle fracture can result in an alteration of the anatomical axes and distribution of the load on the ankle, with consequent development of chronic pain and articular degeneration. The aim of this study is to evaluate the results of the articular re-balancing with realignment and lengthening of the fibula in case of malunited distal fibular fractures.

Methods: A review of prospectively collected data was performed for all patients with a diagnosis of malunion of the fibula and underwent ankle joint re-balancing with fibular lengthening. Read More

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http://dx.doi.org/10.1007/s00264-020-04690-yDOI Listing

Symptoms of Internet Gaming Disorder, Inattention, and Impulsivity: a Cross-Sectional Study Conducted in the United Arab Emirates.

Authors:
Zahir Vally

Psychiatr Q 2020 Jul 8. Epub 2020 Jul 8.

Department of Cognitive Sciences, United Arab Emirates University, P. O. Box 1551, Al Ain, UAE.

The addictive use of internet video games is now recognized as a valid diagnostic construct by both the World Health Organization and the American Psychiatric Association. A burgeoning body of preliminary evidence points to a relationship between attention deficit and hyperactivity disorder (ADHD) symptoms as being a risk factor for behaviors indicative of internet gaming disorder (IGD), however, studies have rarely examined ADHD's two diagnostic constructs, inattention and impulsivity, separately. Moreover, IGD research is non-existent in Middle Eastern contexts. Read More

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http://dx.doi.org/10.1007/s11126-020-09799-2DOI Listing