137,491 results match your criteria American health & drug benefits[Journal]


Indications for Mechanical Thrombectomy Too Wide or Too Narrow?

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

The indications for mechanical thrombectomy (MT) have expanded since the American Heart Association/American Stroke Association (AHA/ASA) published its first guideline on MT in 2013. Multiple subsequent randomized clinical trials of MT have proven its efficacy, including the DAWN and DEFUSE 3 trials. The current guideline from AHA/ASA provides Class I support for the use of MT for the following indications: 1. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.116DOI Listing

Bioethical Issues in Biostatistical Consulting Study: Additional Findings and Concerns.

JDR Clin Trans Res 2019 Apr 22:2380084419837294. Epub 2019 Apr 22.

3 Department of Epidemiology and Health Promotion, College of Dentistry, New York University, New York City, NY, USA.

Objectives: To determine the frequency and severity of 17 requests for inappropriate analysis and reporting of data that biostatisticians received from researchers in statistical consultations, as indirectly experienced (i.e., either heard about or observed being asked of other biostatisticians). Read More

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http://dx.doi.org/10.1177/2380084419837294DOI Listing

Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos.

PLoS One 2019 22;14(4):e0215378. Epub 2019 Apr 22.

Institute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, United States of America.

Objective: Hispanics/Latinos have some of the highest prevalence rates for cardiovascular disease risk factors, but stark differences exist by self-reported background. Cardiovascular disease risk factors negatively impact cognition in Hispanics/Latinos; less is known about these relationships by Hispanic/Latino backgrounds. We investigated cognitive associations with cardiovascular disease risk factor burden in a diverse cohort, the Hispanic Community Health Study/Study of Latinos. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215378PLOS
April 2019
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Comment on "US FDA Breast Implant Postapproval Studies: Long-term Outcomes in 99,993 Patients".

Ann Surg 2019 Apr 18. Epub 2019 Apr 18.

Past President, American Society of Plastic Surgeons, Lenox Hill Hospital/Manhattan Eye, Ear, and Throat Hospital, Northwell Health System, Hofstra School of Medicine, New York, NY Past President, American Society for Aesthetic Plastic Surgery, Aesthetic Plastic Surgical Institute, Laguna Beach, CA; Loma Linda University, Loma Linda, CA Past President, American Society for Aesthetic Plastic Surgery, Private Practice, Eugene, OR Loma Linda University Medical Center, Loma Linda, CA.

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http://dx.doi.org/10.1097/SLA.0000000000003293DOI Listing
April 2019
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Clinical Factors Associated With Cost in Head and Neck Cancer: Implications for a Bundled Payment Model.

J Oncol Pract 2019 Apr 22:JOP1800665. Epub 2019 Apr 22.

3 Levine Cancer Institute, Atrium Health, Charlotte, NC.

Purpose: To determine which factors influence cost in head and neck cancer (HNC) to inform the development of a bundled payment model (BPM).

Methods: Patients with stages 0 to IVB (by American Joint Commission on Cancer, 7th edition) HNC of various sites and histology treated definitively at a single tertiary care center during 2013 were included. Clinical variables and direct cost data were obtained, and their associations were investigated using χ, , Wilcoxon rank sum, and analysis of variance testing. Read More

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http://dx.doi.org/10.1200/JOP.18.00665DOI Listing

Identifying Gaps in Frontline Healthcare Facility High-Consequence Infectious Disease Preparedness.

Health Secur 2019 Mar/Apr;17(2):117-123

Saskia Popescu, MPH, MA, is an Infection Preventionist and Research Assistant, George Mason University, Fairfax, Virginia. Rebecca Leach, MPH, RN, is an Infection Preventionist, Phoenix, Arizona.

Hospital infection disease preparedness gaps were brought to the forefront during the 2013-2016 Ebola virus disease (EVD) outbreak. The ability of US hospitals to rapidly identify, isolate, and manage patients with potentially high-consequence pathogens is a critical component to health security. Since the EVD cases in Dallas, Texas, the continuity of hospital preparedness has been questionable. Read More

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https://www.liebertpub.com/doi/10.1089/hs.2018.0098
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http://dx.doi.org/10.1089/hs.2018.0098DOI Listing
April 2019
1 Read

Dataset for reporting of carcinoma of the urethra (in urethrectomy specimens): recommendations from the International Collaboration on Cancer Reporting (ICCR).

Histopathology 2019 Apr 22. Epub 2019 Apr 22.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, IUH Pathology Laboratory, Indianapolis, IN, USA.

Aims: The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation sponsored by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Association of Pathologists in association with the Canadian Partnership Against Cancer, the European Society of Pathology, the American Society of Clinical Pathology and the Faculty of Pathology, Royal College of Physicians of Ireland. Its goal is to produce standardized, internationally agreed upon, evidence-based datasets for cancer pathology reporting throughout the world.

Methods And Results: This paper describes the development of a cancer dataset by the multidisciplinary ICCR expert panel for the reporting of carcinoma of the urethra in urethrectomy specimens. Read More

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http://dx.doi.org/10.1111/his.13877DOI Listing

Between the Error Bars: How Modern Theory, Design, and Methodology Enrich the Personality-Health Tradition.

Psychosom Med 2019 Apr 18. Epub 2019 Apr 18.

Department of Psychology University of Kentucky 125 Kastle Hall Lexington, KY 40506-0044

The study of relationships between personality traits and health has a long history in psychosomatic research. However, personality science has evolved from an understanding of personality as fixed traits to one that acknowledges that personality is dynamic. Dynamic approaches to conceptualizing and measuring personality and individual differences can enrich personality-health research. Read More

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http://dx.doi.org/10.1097/PSY.0000000000000701DOI Listing

Chemotherapy-induced peripheral neuropathy: where are we now?

Authors:
Lesley A Colvin

Pain 2019 May;160 Suppl 1:S1-S10

Chair of Pain Medicine, Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland.

Chemotherapy-induced peripheral neuropathy (CIPN) is a major challenge, with increasing impact as oncological treatments, using potentially neurotoxic chemotherapy, improve cancer cure and survival. Acute CIPN occurs during chemotherapy, sometimes requiring dose reduction or cessation, impacting on survival. Around 30% of patients will still have CIPN a year, or more, after finishing chemotherapy. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001540DOI Listing

Hospital risk-based payments and physician employment: Impact on financial performance.

Authors:
Gloria J Bazzoli

Health Care Manage Rev 2019 Apr 17. Epub 2019 Apr 17.

Gloria J. Bazzoli, PhD, is Bon Secours Professor, Department of Health Administration, College of Health Professions, Virginia Commonwealth University, Richmond. E-mail:

Background: Hospital involvement in risk-based payment and employment of physicians can have a large impact on their profitability. Risk-based reimbursement approaches with third-party payers and provider-sponsored insurance products hold hospital organizations financially accountable for a range of patient services. Direct employment of physicians can add new revenue sources for the hospital but comes at the high cost of physician compensation packages. Read More

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http://dx.doi.org/10.1097/HMR.0000000000000245DOI Listing

The Effect of Vitamin D Supplements on Clinical and Para-Clinical Outcomes in Patients With Multiple Sclerosis: Protocol for a Systematic Review.

JMIR Res Protoc 2019 Apr 22;8(4):e12045. Epub 2019 Apr 22.

Bristol-Myers Squibb, Uxbridge, United Kingdom.

Background: Multiple sclerosis (MS) is an inflammatory disease, which has a wide range of effects on patients. There are controversies regarding the role of vitamin D in clinical and laboratory improvements in MS patients.

Objective: The aim of this systematic review protocol is to evaluate the efficacy of vitamin D supplements on relapse rate, gadolinium-enhancing lesions of magnetic resonance imaging (MRI), and cytokine profiles. Read More

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http://dx.doi.org/10.2196/12045DOI Listing

PPAR-δ Activation Ameliorates Diabetes-Induced Cognitive Dysfunction by Modulating Integrin-linked Kinase and AMPA Receptor Function.

J Am Coll Nutr 2019 Apr 22:1-10. Epub 2019 Apr 22.

a Department of Drug Discovery and Development, Harrison School of Pharmacy , Auburn University , Auburn , Alabama , USA.

An estimated 9% of the American population experiences type II diabetes mellitus (T2DM) due to diet or genetic predisposition. Recent reports indicate that patients with T2DM are at increased risk for cognitive dysfunctions, as observed in conditions like Alzheimer's disease (AD). In addition, AD is the leading cause of dementia, highlighting the urgency of developing novel therapeutic targets for T2DM-induced cognitive deficits. Read More

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http://dx.doi.org/10.1080/07315724.2019.1598307DOI Listing

Examining race as a predictor and moderator of treatment outcomes for binge-eating disorder: Analysis of aggregated randomized controlled trials.

J Consult Clin Psychol 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychiatry, School of Medicine, Yale University.

Objective: To examine whether race predicted or moderated response to treatments for binge-eating disorder (BED).

Method: Participants were 592 adults (n = 113 Black; n = 479 White) with DSM-IV-defined BED who participated in randomized controlled trials (RCTs) at 1 medical center. Data were aggregated from RCTs for BED testing cognitive-behavioral therapy, behavioral weight loss, multimodal treatment, and/or control conditions. Read More

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http://dx.doi.org/10.1037/ccp0000404DOI Listing

Visualization of the intrarenal distribution of capillary blood flow.

Physiol Rep 2019 Apr;7(8):e14065

Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.

This study describes a modified technique to fill the renal vasculature with a silicon rubber (Microfil) compound and obtain morphologic information about the intrarenal distribution of capillary blood flow under a variety of conditions. Kidneys and cremaster muscles of rats were perfused in vivo with Microfil using a perfusion pressure equal to the animal's mean arterial pressure at body temperature. Microfil did not alter arteriolar diameter or the pattern of flow in the microcirculation of the cremaster muscle. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.14814/phy2.14065
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http://dx.doi.org/10.14814/phy2.14065DOI Listing
April 2019
1 Read

Clinical efficacy of collateral circulation in the evaluation of endovascular treatment for acute internal carotid artery occlusion.

Heliyon 2019 Apr 8;5(4):e01476. Epub 2019 Apr 8.

Department of Neurology, People's Hospital of Linyi, Linyi, Shandong, China.

Objectives: Despite successful recanalization, there remain many patients suffering bad outcome after endovascular treatment, especially for occlusion at the distal portion of internal carotid artery. The goal of the current study was to investigate the value of collateral circulation in predicting malignant events after endovascular treatment in acute ischemic stroke-terminal internal carotid artery (AIS-TICA) patients.

Methods: The records of forty-one patients with AIS-TICA as confirmed by digital subtraction angiography and subjected to mechanical thrombectomy were reviewed. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458472PMC

Atmospheric levels of BPA associated with particulate matter in an urban environment.

Heliyon 2019 Apr 8;5(4):e01419. Epub 2019 Apr 8.

Instituto Multidisciplinario de Biología Vegetal, CONICET and FCEFyN, Universidad Nacional de Córdoba, Av. Vélez Sarsfield 1611, X5016 GCA Córdoba, Argentina.

Bisphenol A (BPA) is an Endocrine disruptor compound (EDC), capable of interfering with hormone related pathways and cause adverse effects, for example, in the reproductive system in wildlife and humans. As it has multiple applications and uses, mainly in the manufacturing of plastic and resin products, increasing amounts are being released into the environment with resulting enhanced exposure pathways. Since negative effects have been demonstrated even at low doses, it has been increasingly studied. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454204PMC

Frequency of Workplace Burnout Among Postgraduate Trainees in a Teaching Hospital in Mirpur.

Cureus 2019 Feb 5;11(2):e4016. Epub 2019 Feb 5.

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.

Background: Work-related stress and burnout among medical practitioners has been a frequently studied phenomenon. It reduces work efficiency and productivity and also has negative impacts on patient care. This study assessed the extent of work-related stress and burnout and the reasons behind this burnout among the Internal Medicine and Pulmonology residents of Mirpur, Azad Kashmir. Read More

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http://dx.doi.org/10.7759/cureus.4016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453621PMC
February 2019

Correction to: Eosinophilic esophagitis.

Allergy Asthma Clin Immunol 2019 10;15:22. Epub 2019 Apr 10.

4Division of Allergy, Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, NS Canada.

[This corrects the article DOI: 10.1186/s13223-018-0287-0.]. Read More

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http://dx.doi.org/10.1186/s13223-019-0336-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456987PMC

Virulence factor RNA transcript expression in the subgenus: influence of species, isolate source, and RNA virus-1.

Trop Med Health 2019 11;47:25. Epub 2019 Apr 11.

1Institute of Medical Sciences, University of Toronto, Toronto, ON Canada.

Background: RNA virus-1 (LRV1) is a double-stranded RNA virus identified in 20-25% of -species endemic to Latin America, and is believed to accelerate cutaneous to mucosal leishmaniasis over time. Our objective was to quantify known virulence factor (VF) RNA transcript expression according to LRV1 status, causative species, and isolate source.

Methods: Eight cultured isolates of were used, four of which were LRV1-positive ( [ = 1], . Read More

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http://dx.doi.org/10.1186/s41182-019-0153-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458769PMC

Impact of the HealthMatters Train-the-Trainer Program on the Health and Health Behaviors of Staff Supporting Adults With Intellectual and Developmental Disabilities.

Workplace Health Saf 2019 Apr 21:2165079919828739. Epub 2019 Apr 21.

3 American College of Surgeons.

The health status and health behaviors among support staff providing daily support for people with intellectual and developmental disabilities (IDD-SS) in community-based organizations (CBOs) have not been systematically studied. This study examined the health impact of IDD-SS workers who participated in a HealthMatters Program: Train-the-Trainer Certified Instructor Workshop followed by implementing a 12-week HealthMatters Program for people with intellectual and developmental disabilities (IDD) that they care for as part of their employment. A total of 48 IDD-SS were enrolled into either an intervention ( n = 28) or control group ( n = 20). Read More

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http://dx.doi.org/10.1177/2165079919828739DOI Listing

Association of pneumonia, wound infection and sepsis with clinical outcomes after acute traumatic spinal cord injury.

J Neurotrauma 2019 Apr 22. Epub 2019 Apr 22.

St. Michael's Hospital, Division of Neurosurgery, Toronto, Canada ;

Pneumonia, wound infections and sepsis (PWS) are the leading causes of acute mortality after traumatic spinal cord injury (SCI). However, the impact of PWS on neurological and functional outcomes is largely unknown. The present study analysed participants from the prospective North American Clinical Trials Network (NACTN) registry and the Surgical Timing in Acute SCI Study (STASCIS) for the association between PWS and functional outcome (assessed as Spinal Cord Independence Measure subscores for respiration and indoor ambulation) at 6 months postinjury. Read More

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http://dx.doi.org/10.1089/neu.2018.6245DOI Listing

Results of the Workplace Health in America Survey.

Am J Health Promot 2019 Apr 22:890117119842047. Epub 2019 Apr 22.

1 Department of Health Behavior, UNC Gillings School of Global Public Health, Chapel Hill, NC, USA.

Purpose: To provide a nationally representative snapshot of workplace health promotion (WHP) and protection practices among United States worksites.

Design: Cross-sectional, self-report Workplace Health in America (WHA) Survey between November 2016 and September 2017.

Setting: National. Read More

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http://dx.doi.org/10.1177/0890117119842047DOI Listing
April 2019
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Prediction of adverse perinatal outcomes by fetal biometry: a comparison of customized and population-based standards.

Ultrasound Obstet Gynecol 2019 Apr 22. Epub 2019 Apr 22.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS).

Objective: To compare the predictive ability of estimated fetal weight (EFW) percentiles, according to seven growth standards, to detect fetuses at risk for adverse perinatal outcomes.

Methods: This retrospective cohort study included 3,437 African-American women. Population-based (Hadlock, INTERGROWTH-21st, WHO, FMF), ethnic specific (NICHD), customized (GROW) and African American customized (PRB/NICHD) growth standards were applied to the last available scan prior to delivery. Read More

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http://dx.doi.org/10.1002/uog.20299DOI Listing

Correlates, Trends, and Short-Term Outcomes of Venous Thromboembolism in Hospitalized Patients with Hepatocellular Carcinoma.

J Gastrointest Cancer 2019 Apr 22. Epub 2019 Apr 22.

Division of Gastroenterology and Hepatology, Saint Louis University, St Louis, MO, USA.

Background And Aim: The incidence and overall mortality of hepatocellular carcinoma (HCC) in the US have been increasing over the past decade. Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in cancer patients. This study aims at examining the epidemiology, risk factors, and short-term outcomes of VTE in hospitalized patients with HCC. Read More

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http://dx.doi.org/10.1007/s12029-019-00242-9DOI Listing

Clinico-pathologic and mammographic characteristics of inflammatory and non-inflammatory breast cancer at six centers in North Africa.

Breast Cancer Res Treat 2019 Apr 22. Epub 2019 Apr 22.

Medical School of the City University of New York, New York, NY, USA.

Purpose: We describe the clinico-pathologic and mammographic characteristics of inflammatory breast cancer (IBC) and non-IBC cases enrolled in a case-control study. Because IBC is a clinico-pathologic entity with rapid appearance of erythema and other signs, its diagnosis is based on clinical observation and thus, by necessity, subjective. Therefore, we evaluate our cases by photographic review by outside expert clinicians and by degree of adherence to the two most recent definitions of IBC: the international expert panel consensus statement and American Joint Committee on Cancer (AJCC) 8th edition (we used the slightly less restrictive 7th edition definition for our study). Read More

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http://dx.doi.org/10.1007/s10549-019-05237-5DOI Listing

Multi-center evaluation of oxidation-reduction potential by the MiOXSYS in males with abnormal semen.

Asian J Androl 2019 Apr 16. Epub 2019 Apr 16.

Tulane University, New Orleans, LA 70118, USA.

According to the World Health Organization (WHO), oxidative stress (OS) is a significant contributor to male infertility. Seminal OS can be measured by a number of assays, all of which are either costly or time sensitive and/or require large semen volume and complex instrumentation. One less expensive alternative is to quantify the oxidation-reduction potential (ORP) with the MiOXSYS. Read More

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http://dx.doi.org/10.4103/aja.aja_5_19DOI Listing

Reduced semen quality in patients with testicular cancer seminoma is associated with alterations in the expression of sperm proteins.

Asian J Androl 2019 Apr 16. Epub 2019 Apr 16.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.

Testicular cancer seminoma is one of the most common types of cancer among men of reproductive age. Patients with this condition usually present reduced semen quality, even before initiating cancer therapy. However, the underlying mechanisms by which testicular cancer seminoma affects male fertility are largely unknown. Read More

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http://dx.doi.org/10.4103/aja.aja_17_19DOI Listing

Normal polysomnography parameters in healthy adults: a systematic review and meta-analysis.

Lancet Respir Med 2019 Apr 18. Epub 2019 Apr 18.

Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada; Department of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada; Sleep Laboratory, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Background: Existing normal polysomnography values are not truly normative as they are based on small sample sizes due to the fact that polysomnography is expensive and burdensome to obtain. There is a clear need for a large sample of truly normative data for clinical management and research. This study is a comprehensive meta-analysis of adult polysomnography parameters scored using recent criteria and establishes normative values adjusted for age and sex. Read More

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http://dx.doi.org/10.1016/S2213-2600(19)30057-8DOI Listing

Four human diseases with significant public health impact caused by mosquito-borne flaviviruses: West Nile, Zika, dengue and yellow fever.

Semin Diagn Pathol 2019 Apr 17. Epub 2019 Apr 17.

Anatomic Pathology and Molecular Oncology, University of Utah, Salt Lake City, UT, United States.

In this review we will discuss the epidemiology, clinical characteristics, diagnostic tests, pathologic features, treatment and disease prevention strategies for four mosquito-borne flaviviruses. West Nile and Zika viruses, once thought to be restricted geographically, emerged on the American continent in the first part of the 21st century. They have been constantly in the lay press and have caused a heightened awareness of emerging infections by the public, particularly given the manifestation of microcephaly in congenital Zika syndrome. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.04.009DOI Listing

Understanding Underuse of Advance Care Planning Among a Cohort of African American Patients With Advanced Cancer: Formative Research That Examines Gaps in Intent to Discuss Options for Care.

Am J Hosp Palliat Care 2019 Apr 21:1049909119843276. Epub 2019 Apr 21.

2 Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.

Background: Advance care planning (ACP), palliative care (PC), and hospice are often underutilized by African Americans (AAs). This study assessed the impact of stage of intent to discuss ACP options as key potential barriers.

Methods: We examined intent to discuss completion of ACP, PC, and hospice among 22 AA patients with cancer admitted to a local safety net hospital. Read More

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http://dx.doi.org/10.1177/1049909119843276DOI Listing

Parental punitive discipline and children's depressive symptoms: Associations with striatal volume.

Dev Psychobiol 2019 Apr 21. Epub 2019 Apr 21.

Teachers College, Columbia University, New York, New York.

Although parental harshness has been consistently linked with increased depressive symptoms in youth, its associations with children's brain structure are not well understood. The striatum has been strongly implicated in depression in adolescents and adults. In this study, we investigated the associations among parental harsh discipline, striatal volume, and depressive symptoms in children. Read More

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http://dx.doi.org/10.1002/dev.21859DOI Listing

HPV vaccine, Twitter, and gay, bisexual and other men who have sex with men.

Health Promot Int 2019 Apr 21. Epub 2019 Apr 21.

Drexel University Dornsife School of Public Health, 3215 Market St., Philadelphia, PA 19104, USA.

This study aimed to quantify human papillomavirus (HPV) vaccine Twitter messaging addressing gay, bisexual and other men who have sex with men (GB+MSM) and describes messaging by vaccine sentiment (attitudes towards vaccine) and characteristics (topic of messaging). Between August 2014 and July 2015, we collected 193 379 HPV-related tweets and classified them by vaccine sentiment and characteristics. We analysed a subsample of tweets containing the terms 'gay', 'bisexual' and 'MSM' (N = 2306), and analysed distributions of sentiment and characteristics using chi-square. Read More

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http://dx.doi.org/10.1093/heapro/daz030DOI Listing

Impact of pretransplant mitral annular calcification on the incidence of cardiac events after renal transplantation.

Nephrol Dial Transplant 2019 Apr 21. Epub 2019 Apr 21.

Division of Cardiology, Cook County Health, Chicago, IL, USA.

Background: Mitral annular calcification (MAC) is associated with increased risk of major adverse cardiac events. We hypothesized that MAC, identified on a pretransplant transthoracic echocardiography (TTE), is predictive of cardiac events following renal transplantation (RT).

Methods: In a retrospective cohort of consecutive RT recipients, pretransplant MAC presence and severity were determined on TTE performed within 1 year prior to transplant. Read More

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https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt
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http://dx.doi.org/10.1093/ndt/gfz063DOI Listing
April 2019
1 Read

Social support from friends and depression among African Americans: The moderating influence of education.

J Affect Disord 2019 Apr 8;253:1-7. Epub 2019 Apr 8.

Center for the Study of Aging and Human Development, Duke University, Durham, NC 27710.

Background: This cross-sectional study examined the association between various characteristics of friendships and 12-month major depressive disorder (MDD) and whether these associations vary by education level among African Americans.

Methods: The analytic sample included 3434 African American respondents drawn from the National Survey of American Life: Coping with Stress in the 21st Century. Logistic regression analyses were performed to test the associations between friendship characteristics (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183301
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http://dx.doi.org/10.1016/j.jad.2019.04.013DOI Listing
April 2019
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Hospital Operative Volume Is an Essential Quality Indicator for General Surgery Operations Performed Emergently in Geriatric Patients.

J Am Coll Surg 2019 Mar 21. Epub 2019 Mar 21.

Section of General Surgery, Trauma, and Surgical Critical Care; Department of Surgery; Yale School of Medicine, New Haven, CT.

Background: Within the growing geriatric population, there is an increasing need for emergency operations. Optimizing outcomes may require a structured system of surgical care based on key quality indicators. To investigate this, the present study sought to answer two questions. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2019.02.053DOI Listing

Risk factors associated with revision for prosthetic joint infection following knee replacement: an observational cohort study from England and Wales.

Lancet Infect Dis 2019 Apr 17. Epub 2019 Apr 17.

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK. Electronic address:

Background: Prosthetic joint infection is a devastating complication of knee replacement. The risk of developing a prosthetic joint infection is affected by patient, surgical, and health-care system factors. Existing evidence is limited by heterogeneity in populations studied, short follow-up, inadequate power, and does not differentiate early prosthetic joint infection, most likely related to the intervention, from late infection, more likely to occur due to haematogenous bacterial spread. Read More

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http://dx.doi.org/10.1016/S1473-3099(18)30755-2DOI Listing

Untangling the ethical intersection of epidemiology, human subjects research, and public health.

Ann Epidemiol 2019 Mar 27. Epub 2019 Mar 27.

Division of Epidemiology and Population Sciences, Department of Public Health Sciences, University of Miami, Miami, FL.

Purpose: Members of the American College of Epidemiology (ACE) Ethics Committee identified current ethics and epidemiology topic areas to consider for further discussion, consultation, teaching opportunities, and conference presentation. This article reflects on the activities of the Committee at the ACE Annual Meeting in New Orleans, Louisiana, September 24-26, 2017.

Methods: The overall aim for the Ethics Committee was to engage members of the College and other audiences and highlight the evolution of ethics and epidemiology since the inception of the original Ethics Guidelines published by the ACE Ethics and Standards of Practice Committee in 2000. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10472797183095
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http://dx.doi.org/10.1016/j.annepidem.2019.03.009DOI Listing
March 2019
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Mind the gap: observation windows to define periods of event ascertainment as a quality control method for longitudinal electronic health record data.

Ann Epidemiol 2019 Mar 4. Epub 2019 Mar 4.

Johns Hopkins University, Baltimore, MD.

Purpose: Use of electronic health records (EHRs) in health research may lead to the false assumption of complete event ascertainment. We estimated "observation windows" (OWs), defined as periods within which the assumption of complete ascertainment of events is more likely to hold, as a quality control approach to reducing the likelihood of this false assumption. We demonstrated the impact of OWs on estimating the rates of type II diabetes mellitus (diabetes) from HIV clinical cohorts. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10472797183054
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http://dx.doi.org/10.1016/j.annepidem.2019.01.015DOI Listing
March 2019
1 Read

Cervical Cancer Death Rates Among U.S.- and Foreign-Born Women: U.S., 2005-2014.

Am J Prev Med 2019 Apr 12. Epub 2019 Apr 12.

Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia. Electronic address:

Introduction: Historically, foreign-born women in the U.S. are less likely to be screened and are more likely to die from cervical cancer when compared with their U. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07493797193004
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http://dx.doi.org/10.1016/j.amepre.2019.01.007DOI Listing
April 2019
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A propensity score matched analysis of the effects of African American race on the characteristics of regions of interests detected by magnetic resonance imaging of the prostate.

Urol Oncol 2019 Apr 17. Epub 2019 Apr 17.

Vattikuti Urology Institute and the Department of Urology, Henry Ford Health System, Detroit, MI. Electronic address:

Objectives: To evaluate the effects of African American (AA) race on the number, location, Prostate Imaging Reporting and Data System (PI-RADS) score, cancer detection rate, and cancer upgrade rate of the regions of interest (ROI) discovered on mltiparametric magnetic resonance imaging (mp-MRI) of the prostate.

Methods: We performed an institutional retrospective study of 592 patients who received a prostate mp-MRI. Number of ROI (1-4), their location, and PI-RADS score v2 were evaluated in a matched cohort of Caucasian and AA males. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10781439193013
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http://dx.doi.org/10.1016/j.urolonc.2019.03.017DOI Listing
April 2019
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HPV detection and genotyping of head and neck cancer biopsies by molecular testing with regard to the new oropharyngeal squamous cell carcinoma classification based on HPV status.

Pathology 2019 Apr 17. Epub 2019 Apr 17.

Laboratoire de virologie, Hôpital Européen Georges Pompidou, and Assistance Publique - Hôpitaux de Paris, Paris, France; Faculté de Médecine Paris Descartes, Université Paris Descartes (Paris V), Sorbonne Paris Cité, Paris, France. Electronic address:

Recently, both the World Health Organization/International Agency for Research on Cancer (WHO/IARC) and the American Joint Committee on Cancer (AJCC) have classified oropharyngeal squamous cell carcinoma (OPSCC) on the basis of HPV status. For this purpose, the WHO/IARC recommended direct molecular HPV testing. In practice, formalin-fixed, paraffin-embedded (FFPE) biopsy specimens are frequently the only available samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183059
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http://dx.doi.org/10.1016/j.pathol.2019.02.002DOI Listing
April 2019
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Integrating Bleeding Control Training Into Surgical Missions in Low- and Middle-Income Countries.

J Surg Res 2019 Apr 17;241:53-56. Epub 2019 Apr 17.

Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey.

Background: Basic bleeding control (BCon) techniques can save lives globally but the knowledge is not widespread in low-income countries where trauma is a common cause of death. Short-term surgical missions (STSMs) are an effective route to share this public health initiative around the world.

Materials And Methods: Over 2017-2018, the International Surgical Health Initiative organized STSMs to locations in Sierra Leone, Bangladesh, Peru, and Ghana. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.020DOI Listing
April 2019
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AAPT Diagnostic Criteria for Chronic Painful Temporomandibular Disorders.

J Pain 2019 Apr 17. Epub 2019 Apr 17.

Departments of Psychiatry and Behavioral Sciences, and Oral Medicine, Schools of Medicine and Dentistry, University of Washington (Emeritus).

The classification of temporomandibular disorders (TMD) has progressed substantially over the past 25 years due to the strategic implementation of an initial classification system based on core taxonomic principles. In this article we describe the development of the DC/TMD and its translation into the multidimensional ACTTION-American Pain Society Pain Taxonomy (AAPT) for chronic pain disorders. The initial scientific classification system (RDC/TMD) relied upon a boot-strapping process that did not attempt to solve all known clinical problems but, rather, focused on problems that could be solved at that time. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.04.003DOI Listing

Race-associated expression of MHC class I polypeptide-related sequence A (MICA) in prostate cancer.

Exp Mol Pathol 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA; Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USA; Center for Clinical and Translational Science (CCTS), University of Mississippi School of Pharmacy & University of Mississippi Medical Center, Jackson, MS, USA. Electronic address:

Despite the lack of a complete understanding of the disparities involved, prostate cancer (PCa) has both higher incidence and death rates in African American Men (AAM) relative to those of Caucasian American Men (CAM). MHC class I polypeptide related sequence A (MICA) is an innate immunity protein involved in tumor immunoevasion. Due to a lack of reports of race-specific expression of MICA in PCa, we evaluated MICA expression in patients' tumors and in cell lines from a racially diverse origin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144800193014
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http://dx.doi.org/10.1016/j.yexmp.2019.04.010DOI Listing
April 2019
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Molecular Characterization of sessile serrated adenoma/polyps from a large African American cohort.

Gastroenterology 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology, Howard University College of Medicine, Washington DC.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193670
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http://dx.doi.org/10.1053/j.gastro.2019.04.015DOI Listing
April 2019
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Economic Evaluation of Sarilumab in the Treatment of Adult Patients with Moderately-to-Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Conventional Synthetic Disease-Modifying Antirheumatic Drugs.

Adv Ther 2019 Apr 19. Epub 2019 Apr 19.

University of Nebraska Medical Center, Omaha, NE, USA.

Introduction: Assess the cost-effectiveness (US healthcare payer perspective) of sarilumab subcutaneous (SC) 200 mg + methotrexate versus conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) or targeted DMARD + methotrexate for moderate-to-severe rheumatoid arthritis (RA) in adults with inadequate response to methotrexate.

Methods: Microsimulation based on patient profiles from MOBILITY (NCT01061736) was conducted via a 6-month decision tree and lifetime Markov model with 6-monthly cycles. Treatment response at 6 months was informed by a network meta-analysis and based on American College of Rheumatology (ACR) response. Read More

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http://link.springer.com/10.1007/s12325-019-00946-1
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http://dx.doi.org/10.1007/s12325-019-00946-1DOI Listing
April 2019
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LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease.

Mol Neurobiol 2019 Apr 19. Epub 2019 Apr 19.

Laboratory for Experimental Mouse Genetics, Department of Human Genetics, KU Leuven, Herestraat 49, Box 604, 3000, Leuven, Belgium.

The low-density lipoprotein receptor-related protein-1 (LRP1) has a dual role in the metabolism of the amyloid precursor protein (APP). In cellular models, LRP1 enhances amyloid-β (Aβ) generation via APP internalization and thus its amyloidogenic processing. However, conditional knock-out studies in mice define LRP1 as an important mediator for the clearance of extracellular Aβ from brain via cellular degradation or transcytosis across the blood-brain barrier (BBB). Read More

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http://dx.doi.org/10.1007/s12035-019-1594-2DOI Listing

Cardiovascular Risk in Type 1 Diabetes Mellitus.

Diabetes Ther 2019 Apr 19. Epub 2019 Apr 19.

Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9WU, UK.

Type 1 diabetes mellitus (T1DM) is associated with premature cardiovascular disease (CVD), but the underlying mechanisms remain poorly understood. The American Diabetes Association and the European Association for the Study of Diabetes recently updated their position statement on the management of type 2 diabetes mellitus (T2DM) to include additional focus on cardiovascular risk; improved management of risk factors in T1DM is also needed. There are important differences in the pathophysiology of CVD in T1DM and T2DM. Read More

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http://dx.doi.org/10.1007/s13300-019-0612-8DOI Listing

Cardiovascular Risk Assessment Varies Widely by Calculator and Race/Ethnicity in a Majority Latinx Cohort Living with HIV.

J Immigr Minor Health 2019 Apr 19. Epub 2019 Apr 19.

Research to Advance Community Health (ReACH) Center, UT Health San Antonio, San Antonio, TX, USA.

Comparison of cardiovascular disease (CVD) risk calculators in Latinx majority populations living with HIV can assist clinicians in selecting a calculator and interpreting results. 10-year CVD risks were estimated for 652 patients seen ≥ 2 times over 12 months in a public clinic using three risk calculators: Atherosclerotic CVD risk Calculator (ASCVD), Framingham Risk Calculator (FRC), and Data Collection on Adverse Effects of Anti-HIV Drugs Study (D:A:D) Calculator. Median estimated 10-year CVD risk in this population was highest using FRC (11%), followed by D:A:D (10%), and lowest with ASCVD (5%; p < 0. Read More

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http://dx.doi.org/10.1007/s10903-019-00890-wDOI Listing

Association of body mass index with cardiac resynchronization therapy intention and left ventricular lead implantation failure: insights from the NCDR implantable cardioverter-defibrillator registry.

J Interv Card Electrophysiol 2019 Apr 19. Epub 2019 Apr 19.

Cardiac Electrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Diego, San Diego, CA, USA.

Background: Cardiac resynchronization therapy with defibrillator (CRT-D) implantation involves left ventricular (LV) lead placement for biventricular pacing and is more complex than implantable cardioverter-defibrillator (ICD)-only implantation. Differences in the prescription of CRT-D versus ICD may result from clinician biases based on patient body habitus, and body habitus may be associated with LV lead implantation failure.

Objective: We sought to evaluate whether patient body mass index (BMI) was associated with planned use and implantation failure of CRT-D therapy. Read More

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http://dx.doi.org/10.1007/s10840-019-00550-xDOI Listing