399,237 results match your criteria American Statistician[Journal]


Newborns at risk of Covid-19 - lessons from the last year.

J Perinat Med 2021 Jun 11. Epub 2021 Jun 11.

Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

After more than 1 year of the SARS-CoV-2 pandemic, a great deal of knowledge on how this virus affects pregnant women, the fetus and the newborn has accumulated. The gap between different guidelines how to handle newborn infants during this pandemic has been minimized, and the American Academy of Pediatrics (AAP)'s recommendations are now more in accordance with those of the World Health Organization (WHO). In this article we summarize present knowledge regarding transmission from mother to the fetus/newborn. Read More

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Trends in Operative Treatment of Pediatric and Adolescent Forearm Fractures Among American Board of Orthopaedic Surgery Part II Candidates.

J Pediatr Orthop 2021 Jun 10. Epub 2021 Jun 10.

Department of Orthopaedic Surgery, Brown University/Warren Alpert School of Medicine Warren Alpert School of Medicine at Brown University Brown University, Providence, RI Department of Orthopaedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA.

Background: Pediatric and adolescent forearm fractures are among the most common injuries treated by orthopaedic surgeons. Recent literature shows that there has been an increased interest in operative management for these injuries. The purpose of the current study was to examine the trends in case volume, patient age, surgeon fellowship training, and postoperative complications of surgically treated pediatric forearm fractures over >15-year period of American Board of Orthopaedic Surgery (ABOS) Part II Oral Examination candidates. Read More

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The effectiveness of natalizumab vs fingolimod-A comparison of international registry studies.

Mult Scler Relat Disord 2021 May 8;53:103012. Epub 2021 May 8.

KTU Medical Faculty Farabi Hospital, Trabzon, Turkey.

Background: Natalizumab and fingolimod were the first preparations recommended for disease breakthrough in priorly treated relapsing-remitting multiple sclerosis. Of three published head-to-head studies two showed that natalizumab is the more effective to prevent relapses and EDSS worsening.

Methods: By re-analyzing original published results from MSBase, France, and Denmark using uniform methodologies, we aimed at identifying the effects of differences in methodology, in the MS-populations, and at re-evaluating the differences in effectiveness between the two drugs. Read More

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The impact of cultural immersion service learning on BSN graduates: A quasi-experimental evaluation.

Nurse Educ Pract 2021 May 27;54:103099. Epub 2021 May 27.

Department of Education, Montana State University, USA. Electronic address:

Aim/objective: The cultural immersion service-learning model evaluated in this study sought to facilitate cultural consciousness of culturally congruent nursing care among predominantly White nursing students attending a university that was racially and culturally homogeneous.

Background: Evidence supports the use of cultural immersion service learning during undergraduate nursing programs in developing the skills necessary for effective transcultural healthcare; yet, little is known about its impact beyond the semester of the experience.

Design: This project used a quasi-experimental design to determine if transcultural self-efficacy of BSN graduates among five campuses differed. Read More

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Should we screen Eastern Mediterranean COVID-19 patients for inherited thrombophilia?

Med Hypotheses 2021 Jun 4;152:110621. Epub 2021 Jun 4.

Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

The inflammatory component of Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) creates a pro-thrombotic state that necessitates a thrombophylactic strategy for hospitalized patients. Such strategies are difficult to be standardized because certain individuals can have pro-thrombotic conditions, such as inherited thrombophilia, which pre-dispose them to an additional coagulative risk. Whether outside the hospital or when admitted, patients with inherited thrombophilia need special anticoagulant and antiplatelet attention. Read More

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Heterogeneity in prenatal substance use screening despite universal screening recommendations: findings from PRAMS, 2016-2018.

Am J Obstet Gynecol MFM 2021 Jun 8:100419. Epub 2021 Jun 8.

Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.

Background: The American College of Obstetricians and Gynecologists recommends universal screening for tobacco, alcohol, and drug use as a part of routine prenatal care. However, little is known about the prevalence of prenatal substance use screening or factors that may contribute to differential rates of screening during prenatal care.

Objectives: To describe the prevalence of prenatal substance use screening by substance, year, state, and state-level prenatal substance use policies, and to examine individual-level factors associated with receipt of screening. Read More

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Functional Somatic Syndromes are Associated with Suboptimal Outcomes and High Cost after Shoulder Arthroplasty.

J Shoulder Elbow Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of Orthopaedic Surgery, New England Baptist Hospital, Tufts University School of Medicine, Boston, MA, USA. Electronic address:

Introduction: The presence of functional somatic syndromes (chronic physical symptoms with no identifiable organic cause) in patients undergoing elective joint arthroplasty may affect the recovery experience. We explored the prevalence of functional somatic syndromes among shoulder arthroplasty patients, and their association with postoperative outcomes and costs.

Methods: We identified 480 patients undergoing elective total shoulder arthroplasty (anatomic or reverse) between 2015-2018 in our institutional registry with minimum 2-year follow-up. Read More

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Does statin-treated hyperlipidemia affect rotator cuff healing or muscle fatty infiltration after rotator cuff repair?

J Shoulder Elbow Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of Arthroscopy, Royal Orthopaedic Hospital NHS Foundation Trust, Birmingham, United Kingdom.

Purpose: Hyperlipidemia is linked to poor tendon to bone healing and progression of fatty infiltration after rotator cuff repair. Statins effectively treat hyperlipidemia, but it is unknown if they have any potential detrimental effects following rotator cuff repair. The aim of this study was to evaluate the effect of statins on rotator cuff healing and fatty infiltration following repair. Read More

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Consensus Statement on the Treatment of Massive Irreparable Rotator Cuff Tears - A Delphi Approach by the Neer Circle of the American Shoulder and Elbow Surgeons.

J Shoulder Elbow Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of Orthopedic Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA.

Background: Management of massive irreparable rotator cuff tears (MIRCTs) remains controversial due to variability in patient features and outcomes contributing to a lack of unanimity in treatment recommendations. The purpose of this study was to implement the Delphi process using experts from the Neer Circle of the American Shoulder and Elbow Surgeons (ASES) to determine areas of consensus regarding treatment options for a variety of MIRCTs.

Methods: A panel of 120 shoulder surgeons were sent a survey regarding MIRCT treatments including: arthroscopic débridement and partial cuff repair, graft augmentation, reverse shoulder arthroplasty (RSA), superior capsular reconstruction (SCR), and tendon transfers. Read More

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Review: Adult Outcome as Seen Through Controlled Prospective Follow-up Studies of Children With Attention-Deficit/Hyperactivity Disorder Followed Into Adulthood.

J Am Acad Child Adolesc Psychiatry 2021 Jun 5. Epub 2021 Jun 5.

McGill University Health Center, Montreal, Quebec, Canada; Division of Child Psychiatry, McGill University, Montreal Children's Hospital, McGill University Health Center, Montreal, Quebec, Canada. Electronic address:

Objective: To describe adult outcome of people with childhood diagnosed attention-deficit/hyperactivity disorder (ADHD) and its several key predictors via a review of seven North American controlled prospective follow-up studies: the Montreal, New York, Milwaukee, Pittsburgh, Massachusetts General Hospital (MGH), Berkeley and the seven-site Multimodal Treatment Study of Children with ADHD (MTA).

Method: All studies were prospective and followed children diagnosed with ADHD and an age and gender-matched control group at regular intervals from childhood (6-12 years) through adolescence into adulthood (20-40 years), evaluating symptom and syndrome persistence, functional outcomes and predictors of these outcomes.

Results: The rates of the ADHD syndrome persistence ranged from 5. Read More

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Biplane mode for more precise intrauterine procedures.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Department of Obstetrics and Fetal Medicine, Necker Enfants-Malades Hospital, Paris Descartes University, Paris, France; Université de Paris, Paris, France.

The evolution of ultrasound and the introduction of three and four-dimensional ultrasound techniques led to a shift in the perception and usage of ultrasound in fetal medicine. The biplane mode might help in multiple fetal procedures, including but not limited to, basic intrauterine thoracocentesis, thoraco-amniotic shunting, amnioreduction, amnioinfusion, cordocentesis, intraumbilical infusion and ِumbilical cord coagulation, with a possible reduction in the complication rate. Despite its theoretical usefulness, more studies are required to assess the clinical importance of this technique. Read More

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Radiation Dose Reduction in Kidney Stone CT: A Randomized, Facility-Based Intervention.

J Am Coll Radiol 2021 Jun 8. Epub 2021 Jun 8.

Massachusetts General Hospital, Boston, Massachusetts.

Objective: Kidney stones are common, tend to recur, and afflict a young population. Despite evidence and recommendations, adoption of reduced-radiation dose CT (RDCT) for kidney stone CT (KSCT) is slow. We sought to design and test an intervention to improve adoption of RDCT protocols for KSCT using a randomized facility-based intervention. Read More

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Influence of Telemedicine on the Number of Visits and HbA1c Determinations in Latin American Children with Type 1 Diabetes.

Diabetes Technol Ther 2021 Jun 11. Epub 2021 Jun 11.

University of Buenos Aires, Buenos Aires, Argentina;

Objective: To measure the changes in the number of medical visits and the number of HbA1c determinations according to telemedicine access in children with type 1 diabetes (T1DM) during the pandemic 2020 compared with 2019 and 2018.

Methods: This is a multinational study of children with T1DM from four Latin American countries. The number of medical visits, the number of HbA1c determinations, and access to telemedicine during 2020 were extracted from their records. Read More

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Pathophysiological Aspects of the Development of Abdominal Aortic Aneurysm with a Special Focus on Mitochondrial Dysfunction and Genetic Associations.

Biomol Concepts 2021 Jun 11;12(1):55-67. Epub 2021 Jun 11.

Department of Basic Research, Institute for Atherosclerosis Research, Moscow121609, Russia.

Abdominal aortic aneurysm (AAA) is a complex degenerative vascular disease, with considerable morbidity and mortality rates among the elderly population. The mortality of AAA is related to aneurysm expansion (the enlargement of the aortic diameter up to 30 mm and above) and the subsequent rupture. The pathogenesis of AAA involves several biological processes, including aortic mural inflammation, oxidative stress, vascular smooth muscle cell apoptosis, elastin depletion, and degradation of the extracellular matrix. Read More

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Effects of Acute Dance and Aerobic Exercise on Drug Craving and Food Reward in Women with Methamphetamine Dependence.

Med Sci Sports Exerc 2021 Jun 10. Epub 2021 Jun 10.

School of Psychology, Shanghai University of Sport, Shanghai, People's Republic of China School of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom People's Liberation Army Second Military Medical University Naval Medical University, Department of Orthopedics, Changhai Hospital, Shanghai, People's Republic of China.

Introduction: Drug dependence causes an overestimation of drug-related stimuli and an underestimation of non-drug-related stimuli, such as food. The purpose of this study was to investigate the effects of acute moderate-intensity dance and aerobic exercise on drug craving, appetite, prefrontal neural activation to food cues and food reward in women with MA dependence.

Methods: Thirty-nine women who met the DSM-V MA dependence criteria participated in the experiment and were randomly assigned to either a dance (n = 20) or exercise (n = 19) group. Read More

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Downhill Running Decreases the Acetylation of Tubulins and Impairs Autophagosome Degradation in Rat Skeletal Muscle.

Med Sci Sports Exerc 2021 Jun 11. Epub 2021 Jun 11.

School of Sports Science, Beijing Sport University, Beijing, CHINA College of Rehabilitation, Gannan Medical University, Ganzhou, CHINA.

Purpose: This study was designed to probe the effect of downhill running on microtubule acetylation and autophagic flux in rat skeletal muscle.

Methods: Sprague-Dawley rats were subjected to an exercise protocol of a 90-min downhill run with a slope of -16° and a speed of 16 m/min, and then the soleus was sampled at 0 h, 12 h, 24 h, 48 h, and 72 h after exercise. Protein expression levels of microtubule-associated protein 1 light chain 3 (LC3), p62/sequestosome 1 (p62), α-tubulin and acetylated α-tubulin (AcK40 α-tubulin) were detected by Western blotting. Read More

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U.S. Population-referenced Percentiles for Wrist-Worn Accelerometer-derived Activity.

Med Sci Sports Exerc 2021 Jun 11. Epub 2021 Jun 11.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD Department of Mathematics and Statistics, University of Massachusetts, Amherst, Amherst, MA US Public Health Service, retired, Silver Spring, MD.

Purpose: To present age- and sex- specific percentiles for daily wrist-worn movement metrics in U.S. youth and adults. Read More

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Attitudes Scale on Alcohol, Alcoholism, and Persons with Alcohol Use Disorders.

J Addict Nurs 2021 Jun 10. Epub 2021 Jun 10.

Divane de Vargas, PhD, BSN, MSN, FIAAN, School of Nursing, São Paulo University, Brazil. Madeline A. Naegle, PhD, CNS-PMH, BC, FAAN, Rory Meyers College of Nursing, New York University, New York.

Background: The Attitudes Scale on Alcohol, Alcoholism, and Persons with alcohol use disorders ("Escala de Atitudes Frente ao Álcool, ao Alcoolismo e ao Persons with alcohol use disorders" [EAFAA]) is an instrument designed to measure attitudes toward alcohol, alcoholism, and persons with alcohol use disorders. It has been validated in Portuguese and Spanish.

Objective: The purpose of this study was to examine the psychometric properties and factor structure of the American English version of the EAFAA (EAFAA-AEV). Read More

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Race/ethnicity and advanced stage of renal cell carcinoma in adults: results from surveillance, epidemiology, and end results program 2007-2015.

Eur J Cancer Prev 2021 Jun 10. Epub 2021 Jun 10.

Division of Medical and Population Health Sciences Research Department of Translational Medicine, Herbert Wertheim College of Medicine at Florida International University, Miami, Florida, USA.

Non-Hispanic Blacks were shown to have an earlier stage of renal cell carcinoma (RCC) at diagnosis compared to non-Hispanic Whites. It is less clear whether disparities in RCC staging occurs for other minority races/ethnicities. We aimed to assess the association between racial/ethnic minorities and stage at diagnosis of RCC, and test for potential effect modification by histological subtype. Read More

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Multiyear Group and Medical Center Patch Test Frequency Data: Confounding Variables.

Dermatitis 2021 Jun 9. Epub 2021 Jun 9.

From the Department of Dermatology, School of Medicine, University of California San Francisco Medical School.

Patch test frequency data have been extensively published by research groups, such as the International Contact Dermatitis Research Group, North American Contact Dermatitis Group, Dermato-Allergology Study and Research Group, and European Environmental Contact Dermatitis Research Group. As this knowledge accumulation is widely applied in clinical and public health settings, we describe confounding factors to consider when using such data for medical policy considerations. These concepts can also be used in individual reports of new allergens or series of cases. Read More

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Contact Allergens in Prescription Topical Ophthalmic Medications.

Dermatitis 2021 Jun 9. Epub 2021 Jun 9.

From the Department of Dermatology, Park Nicollet Health Services University of Minnesota Medical School, Minneapolis.

Background/objective: Both active and inactive ingredients in topical ophthalmic agents may cause allergic contact dermatitis. Here, we examined ingredients in prescription topical ophthalmic medications available in the United States.

Methods: A comprehensive list of topical ophthalmic medications was generated using AccessPharmacy. Read More

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Rates of new HIV diagnoses among Indigenous peoples in Canada, Australia, New Zealand, and the United States: 2009-2017.

AIDS 2021 Jun 9. Epub 2021 Jun 9.

BC Centre for Excellence in HIV/AIDS, Vancouver Faculty of Health Sciences, Simon Fraser University, Burnaby Faculty of Medicine, University of British Columbia BC Centre for Disease Control First Nations Health Authority, Vancouver, Canada School of Health, Victoria University of Wellington, New Zealand School of Public Health, University of Queensland Poche Centre for Indigenous Health, University of Queensland, Brisbane, Australia The INA (Māori, Indigenous & South Pacific) HIV & AIDS Foundation.

Objective: To compare rates and trends of HIV diagnoses among Indigenous peoples in Canada (First Nations, Métis, Inuit, and other non-specified), Australia (Aboriginal and Torres Strait Islanders), the USA (American Indian, Alaska Native, Native Hawaiian, and Other Pacific Islanders), and New Zealand (Māori).

Design: We employed publicly available surveillance data from 2009 to 2017 to estimate the rate per 100 000 of HIV diagnoses. Estimated annual percentage change (EAPC) in diagnosis rates was calculated using Poisson regression. Read More

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Trends in Endotracheal Intubation During In-Hospital Cardiac Arrests: 2001-2018.

Crit Care Med 2021 Jun 9. Epub 2021 Jun 9.

Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA. Center for the Study of Healthcare Innovation, Implementation, and Policy, Health Services Research and Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA. Center for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Division of Hospital Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA. Division of Pulmonary, Critical Care Medicine, and Sleep Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Objectives: Airway management during in-hospital cardiac arrest represents a fundamental component of resuscitative efforts, yet little is known about temporal trends in intubation during in-hospital cardiac arrest. Our objective was to investigate changes in in-hospital cardiac arrest airway management over time and in response to national guideline updates.

Design: Observational cohort study of a prospectively collected database. Read More

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Review of the hydraulic capacity of urban grate inlet: a global and Latin American perspective.

Water Sci Technol 2021 Jun;83(11):2575-2596

Facultad de Minas, Departamento de Geociencias y Medio Ambiente, National University of Colombia - Sede Medellín, Medellín, Cr. 80 # 65-223, Colombia.

The most recent numerical models of urban drainage allow the integration of runoff from roads with the network of sewer pipes, thus evolving towards a holistic version of the system. A fundamental part of this integration is the capture of stormwater in urban drain inlets. These studies have recently increased, resulting in different methodologies to represent the uptake process and making it difficult to apply unified or general formulations. Read More

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Survival motor neuron deficiency slows myoblast fusion through reduced myomaker and myomixer expression.

J Cachexia Sarcopenia Muscle 2021 Jun 11. Epub 2021 Jun 11.

Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, MD, USA.

Background: Spinal muscular atrophy is an inherited neurodegenerative disease caused by insufficient levels of the survival motor neuron (SMN) protein. Recently approved treatments aimed at increasing SMN protein levels have dramatically improved patient survival and have altered the disease landscape. While restoring SMN levels slows motor neuron loss, many patients continue to have smaller muscles and do not achieve normal motor milestones. Read More

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Treatment of High-Energy Intra-Articular Fractures of Tibia with Ilizarov External Fixator in Adults: A Tertiary Center Experience.

Int J Clin Pract 2021 Jun 11:e14488. Epub 2021 Jun 11.

Dow University of Health Sciences, Karachi, Pakistan.

Objective: To evaluate the clinical and radiological outcomes of the Ilizarov fixator in the proximal and distal fractures of the tibia.

Materials And Methodology: This retrospective study reviewed 59 patients having high-energy intra-articular proximal and distal tibia fractures associated with severe soft-tissue injury, who were managed surgically with an Ilizarov fixator. The functional outcome was evaluated by using the American Orthopaedic Foot and Ankle Society scoring system (AOFAS) and the Association for the Study and Application of the Method of Ilizarov (ASAMI) Italy scoring system for tibial plateau and plafond fractures respectively. Read More

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Coping with stress in a warming Gulf: the postlarval American lobster's cellular stress response under future warming scenarios.

Cell Stress Chaperones 2021 Jun 11. Epub 2021 Jun 11.

School of Marine Sciences, University of Maine, Orono, ME, 04469, USA.

The Gulf of the Maine (GoM) is one of the fastest warming bodies of water in the world, posing serious physiological challenges to its marine inhabitants. Marine organisms can cope with the cellular and molecular stresses created by climate change through changes in gene expression. We used transcriptomics to examine how exposure to current summer temperatures (16 °C) or temperature regimes reflective of projected moderate and severe warming conditions (18 °C and 22 °C, respectively) during larval development alters expression of transcripts affiliated with the cellular stress response (CSR) in postlarval American lobsters (Homarus americanus). Read More

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Congestive heart failure and comorbidity as determinants of colorectal cancer perioperative outcomes.

Updates Surg 2021 Jun 11. Epub 2021 Jun 11.

Epidemiological Department (SER), Azienda Zero, Via Jacopo Avanzo 35, Veneto Region, 35132, Padua, Italy.

There has been an increase in surgical interventions in frailer elderly with concomitant chronic diseases. The purpose of this paper was to evaluate the impact of aging and comorbidities on outcomes in patients who underwent surgery for the treatment of colorectal cancer (CRC) in Veneto Region (Northeastern Italy). This is a retrospective cohort study in patients ≥ 40 years who underwent elective or urgent CRC surgical resection between January 2013 and December 2015. Read More

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Splenic embolization in trauma: results of a survey from an international cohort.

Emerg Radiol 2021 Jun 11. Epub 2021 Jun 11.

University of Minnesota, 420 Delaware Street SE, Minneapolis, MN, 55455, USA.

Purpose: A questionnaire regarding splenic embolization in trauma was submitted to an international sample of IR faculty members, to compare their practice to the available recommendations.

Methods: A 21 multiple-choice questionnaire was sent to an international cohort of 96 IR faculty. Questions included the initial patient evaluation, embolization materials and techniques, post-procedure management, availability of an institutional protocol, and use of guidelines. Read More

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Analysis of socioeconomic and demographic factors and imaging exam characteristics associated with missed appointments in pediatric radiology.

Pediatr Radiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology, Massachusetts General Hospital, 55 Fruit St., BLK SB-0029A, Boston, MA, 02114, USA.

Background: Missed appointments can have an adverse impact on health outcomes by delaying appropriate imaging, which can be critical in influencing treatment decisions.

Objective: To assess for socioeconomic and imaging exam factors associated with missed appointments among children scheduled for diagnostic imaging.

Materials And Methods: We retrospectively analyzed children (<18 years) scheduled for outpatient diagnostic imaging during a 12-month period. Read More

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