337,857 results match your criteria American Optician[Journal]


Accuracy of Routine Prenatal Genetic Screening in Patients Referred for Genetic Counseling.

Am J Perinatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, Delaware.

Objective:  The American College of Obstetricians and Gynecologists (ACOG) guidelines recommend routine prenatal screening for genetic diseases that could affect the pregnancy. We sought to determine the rate of missed genetic information in the general obstetrician's routine prenatal genetic screening process.

Study Design:  This is a sequential case series of women referred for genetic counseling between March and August of 2015. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678533
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http://dx.doi.org/10.1055/s-0039-1678533DOI Listing
February 2019

Genotypic and Phenotypic Characterization of Candida albicans Lebanese Hospital Isolates Resistant and Sensitive to Caspofungin.

Fungal Genet Biol 2019 Feb 19. Epub 2019 Feb 19.

Department of Natural Sciences, Lebanese American University, PO Box 36, Byblos, Lebanon(1). Electronic address:

The fungus Candida albicans is both a commensal and an opportunistic human pathogen, present as part of the normal human microflora causing serious mucosal, and systemic life threatening infections. The antifungal drug caspofungin of the echinocandin family is the latest generation of antifungal drugs to be developed. It functions by inhibiting glucan synthase thus weakening the fungal cell wall leading to death. Read More

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http://dx.doi.org/10.1016/j.fgb.2019.02.008DOI Listing
February 2019

AUTOLOGOUS HEMATOPOIETIC CELL TRANSPLANTATION FOR TREATMENT-REFRACTORY RELAPSING MULTIPLE SCLEROSIS: POSITION STATEMENT FROM THE AMERICAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION.

Biol Blood Marrow Transplant 2019 Feb 19. Epub 2019 Feb 19.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Multiple sclerosis (MS) is a chronic, disabling, immune-mediated, central nervous system demyelinating and degenerative disease. Approved disease modifying therapies may be incompletely effective in some patients with highly active relapsing disease and high risk of disability. Immunoablative or myeloablative therapy followed by autologous hematopoietic cell transplantation (AHCT) has been investigated in retrospective studies, clinical trials, and meta-analyses/systematic reviews as an approach to address this unmet clinical need. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.014DOI Listing
February 2019

Oral Cancer Treatment Through the Ages: Part 2.

J Oral Maxillofac Surg 2019 Jan 28. Epub 2019 Jan 28.

Consultant Oral and Maxillofacial Head and Neck Surgeon, Northampton General Hospital, Cliftonville, United Kingdom.

In part 1, we learned the foundations of oral cancer and principles of treatment as described by prominent early surgeons and physicians from Hippocrates and Celsus to Henry T. Butlin, the prominent head and neck surgeon. Part 2 commences with the turn of the 20th century and focuses on the evolution of neck dissection, as well as adjunctive treatment options, leading to the reconstructive revolution with a growing focus on quality of life. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.024DOI Listing
January 2019

Ideating iDNA: Lessons and limitations from leeches in legacy collections.

PLoS One 2019 22;14(2):e0212226. Epub 2019 Feb 22.

Department of Biological Sciences, Fordham University, Bronx, New York, United States of America.

Indirect methods for conducting faunal inventories present great promise, and genomic inventories derived from environmental sources (eDNA) are improving. Invertebrate ingested DNA (iDNA) from terrestrial leeches in the family Haemadipsidae has shown potential for surveying vertebrates and biodiversity monitoring in protected areas. Here we present an initial, and critical, evaluation of the limitations and biases of current iDNA protocols for biodiversity monitoring using both standard and NGS barcoding approaches. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212226PLOS
February 2019

Sodium citrate contributes to the platelet storage lesion.

Transfusion 2019 Feb 22. Epub 2019 Feb 22.

Holland Laboratory, The American Red Cross Biomedical Services, Rockville, Maryland.

Background: Sodium citrate has become the preferred anticoagulant used for apheresis collection and has been included in commercial platelet additive solutions (PASs) since PAS-II. It was suggested that citrate be included in PASs to prevent spontaneous aggregation. Reports in cell lines and cord blood have demonstrated that concentrations of citrate present in PAS formulations (10 mM) cause apoptosis. Read More

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http://dx.doi.org/10.1111/trf.15213DOI Listing
February 2019

The Management of Diabetes in Everyday Life (MODEL) program: development of a tailored text message intervention to improve diabetes self-care activities among underserved African-American adults.

Transl Behav Med 2019 Feb 22. Epub 2019 Feb 22.

University of Tennessee Health Science Center, Memphis, TN, USA.

Tailoring health-related materials is an effective mechanism to encourage behavior change; however, little research has described processes and critical characteristics for effective tailoring in underserved populations. The purpose of this study is to describe a process using input from content experts and lay patient advisors to tailor text messages focused on improving self-care behaviors of African-American adults with diabetes and identify characteristics of messages perceived to be most effective. An initial library of tailorable messages was created using theory-based approaches, expert opinion, and publicly available materials. Read More

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http://dx.doi.org/10.1093/tbm/ibz024DOI Listing
February 2019

Association of Physician Organization-Affiliated Political Action Committee Contributions With US House of Representatives and Senate Candidates' Stances on Firearm Regulation.

JAMA Netw Open 2019 Feb 1;2(2):e187831. Epub 2019 Feb 1.

Department of Emergency Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Importance: Many physician professional organizations have endorsed public policies, such as expanded background checks, to reduce firearm-related injury. It is not known whether physician organizations' political giving aligns with these policy endorsements.

Objectives: To compare physician organization-affiliated political action committee (PAC) campaign contributions with US House of Representatives and Senate candidates' stances on firearm safety policies and analyze whether physician organization endorsement of firearm safety policies is associated with contribution patterns. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.7831DOI Listing
February 2019

Contemporary Rates of Preoperative Cardiac Testing Prior to Inpatient Hip Fracture Surgery.

J Hosp Med 2019 Feb 20;14:E1-E5. Epub 2019 Feb 20.

Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.

Hip fracture is a common reason for urgent inpatient surgery. In the past few years, several professional societies have identified preoperative echocardiography and stress testing for noncardiac surgeries as low-value diagnostics. We utilized data on hospitalizations with a primary diagnosis of hip fracture surgery between 2011 and 2015 from the State Inpatient Databases (SID) of Maryland, New Jersey, and Washington, combined with data on hospital characteristics from the American Hospital Association (AHA). Read More

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http://dx.doi.org/10.12788/jhm.3133DOI Listing
February 2019

Making Policy on Augmented Intelligence in Health Care.

AMA J Ethics 2019 Feb 1;21(2):E188-191. Epub 2019 Feb 1.

Vice president of the Environmental Intelligence and Strategic Analytics unit at the American Medical Association in Washington, DC.

In June 2018, the American Medical Association adopted new policy to provide a broad framework for the evolution of artificial intelligence (AI) in health care that is designed to help ensure that AI realizes the benefits it promises for patients, physicians, and the health care community. Read More

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http://dx.doi.org/10.1001/amajethics.2019.188DOI Listing
February 2019

Are Current Tort Liability Doctrines Adequate for Addressing Injury Caused by AI?

AMA J Ethics 2019 Feb 1;21(2):E160-166. Epub 2019 Feb 1.

A senior research associate for the American Medical Association Council on Ethical and Judicial Affairs in Chicago, Illinois, where he is also the legal editor for the AMA Journal of Ethics.

As capabilities of predictive algorithms improve, machine learning will become an important element of physician practice and patient care. Implementation of artificial intelligence (AI) raises complex legal questions regarding health care professionals' and technology manufacturers' liability, particularly if they cannot explain recommendations generated by AI technology. The limited literature on liability for innovation provides opportunities to consider possible implications of AI for medical malpractice and products liability and new legal solutions for addressing liability issues surrounding "black-box" medicine. Read More

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http://dx.doi.org/10.1001/amajethics.2019.160DOI Listing
February 2019

Reimagining Medical Education in the Age of AI.

AMA J Ethics 2019 Feb 1;21(2):E146-152. Epub 2019 Feb 1.

The vice president and founding dean of the School of Health Professions at Eastern Virginia Medical School (EVMS) in Norfolk, Virginia; and a fellow of the Society for Simulation in Healthcare and holds senior faculty appointments in the EVMS School of Health Professions; the Department of Modeling, Simulation and Visualization Engineering at Old Dominion University; Paris Descartes University; and Taipei Medical University.

Available medical knowledge exceeds the organizing capacity of the human mind, yet medical education remains based on information acquisition and application. Complicating this information overload crisis among learners is the fact that physicians' skill sets now must include collaborating with and managing artificial intelligence (AI) applications that aggregate big data, generate diagnostic and treatment recommendations, and assign confidence ratings to those recommendations. Thus, an overhaul of medical school curricula is due and should focus on knowledge management (rather than information acquisition), effective use of AI, improved communication, and empathy cultivation. Read More

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http://dx.doi.org/10.1001/amajethics.2019.146DOI Listing
February 2019

Performance Differences between National Football League and High School American Football Combine Participants.

Res Q Exerc Sport 2019 Feb 22:1-7. Epub 2019 Feb 22.

a University of Nebraska-Lincoln.

Purpose: The purpose of this study was to determine magnitudes of differences for anthropometric and athletic performance scores between high school and elite college-level American football players.

Method: Participants included high school-age (n = 3,666) athletes who participated in American football combines, as well as elite college-level (n = 5,537) athletes who participated in the National Football League (NFL) scouting combine. Combine data included position; height; weight; 10-, 20-, and 40-yard dash; pro-agility (PA); L-cone drill (LC); vertical jump (VJ); and broad jump (BJ). Read More

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http://dx.doi.org/10.1080/02701367.2019.1571679DOI Listing
February 2019

Exploring the Need of HPV Education Programs in Korean American Communities.

J Community Health Nurs 2019 Jan-Mar;36(1):19-30

d College of Nursing , University of Illinois at Chicago , Chicago , IL , USA.

Given the significantly higher cervical cancer risks faced by Korea Americans (KA), the aim of this study was to explore cultural influences and barriers affecting human papillomavirus (HPV) vaccination decisions and preferred educational methods to effectively deliver HPV information. Focus groups included 20 KA parents. This study found a lack of knowledge about HPV and the vaccine, along with negative perceptions about the vaccine, affects HPV vaccination decision-making. Read More

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http://dx.doi.org/10.1080/07370016.2018.1555312DOI Listing
February 2019

Acute kidney injury after hepatectomy can be reasonably predicted after surgery.

J Hepatobiliary Pancreat Sci 2019 Feb 22. Epub 2019 Feb 22.

Department of Anesthesiology, Columbia University Medical Center, New York, NY.

Background: Hepatectomy presents unique challenges potentially heightening acute kidney injury risk, but the full spectrum of risk factors have not been identified.

Methods: Data for hepatectomy patients in the 2016 American College of Surgeons National Surgical Quality Improvement Program (N=3814) was randomly split into derivation (70%) and validation (30%) cohorts. AKI was defined as an increase in serum creatinine ≥0. Read More

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http://dx.doi.org/10.1002/jhbp.615DOI Listing
February 2019

The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting.

Am J Med Genet A 2019 Feb 22. Epub 2019 Feb 22.

Stowers Institute for Medical Research, Kansas City, Missouri.

The mission of the Society for Craniofacial Genetics and Developmental Biology (SCGDB) is to promote education, research, and communication about normal and abnormal development of the tissues and organs of the head. The SCGDB welcomes as members undergraduate students, graduate students, postdoctoral researchers, medical and dental practitioners, scientists, and academicians who possess an interest in craniofacial biology. Each year our members come together to share their novel findings, build upon, and challenge current knowledge of craniofacial biology. Read More

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http://dx.doi.org/10.1002/ajmg.a.61090DOI Listing
February 2019

Applying Heteroatom Substitution in Organic Photovoltaics.

Chem Rec 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, CAN M5S 3H6.

Poly(3-alkylthiophene) (P3AT) has been a central focus of research on organic photovoltaics (OPVs) for well over a decade. Due to their controlled synthesis P3ATs have proven to be a vital model system for developing an understanding of the effects of polymer structure on optoelectronic properties and blend morphology in bulk heterojunction OPVs. Similar to their thiophene counterparts, selenophene and tellurophene can be polymerized in a controlled manner. Read More

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http://dx.doi.org/10.1002/tcr.201800182DOI Listing
February 2019

Readability of consent forms in veterinary clinical research.

J Vet Intern Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio.

Background: "Readability" of consent forms is vital to the informed consent process. The average human hospital consent form is written at a 10th grade reading level, whereas the average American adult reads at an 8th grade level. Limited information currently exists regarding the readability of veterinary general medical or clinical research consent forms. Read More

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http://dx.doi.org/10.1111/jvim.15462DOI Listing
February 2019

Outcomes of surgical treatment for hemangiomas.

Pediatr Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Biostatistics & Bioinformatics, Duke University, Durham, North Carolina.

Objective: To quantify complications and rates of adverse events associated with surgical excision of hemangiomas in children using a national surgical database.

Data Source: Pediatric American College of Surgeons (ACS) National Surgical Quality Improvement Program (ACS NSQIP -pediatric), years 2012-2016.

Methods: Subjects included children under 18 years with a postoperative diagnosis of International Classification of Diseases (ICD), 9th revision code: 228. Read More

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http://dx.doi.org/10.1111/pde.13751DOI Listing
February 2019

spp. Infection Rate and Feeding Patterns of Sand Flies (Diptera: Psychodidae) from a Hyperendemic Cutaneous Leishmaniasis Community in Panamá.

Am J Trop Med Hyg 2019 Feb 18. Epub 2019 Feb 18.

Programa Centroamericano de Maestría en Entomología, Universidad de Panamá, Ciudad de Panamá, Panamá.

American cutaneous leishmaniasis (ACL) is a common and important vector-borne parasitic zoonosis in Panamá. Here, we study spp. infection rates and blood-feeding patterns among common sand flies in Trinidad de Las Minas, a rural community with hyperendemic ACL transmission, and where a deltamethrin fogging trial was performed. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0628DOI Listing
February 2019

Preferences Regarding and Communication About End-of-Life Care Among Older Iranian-American Adults.

West J Nurs Res 2019 Feb 22:193945919832304. Epub 2019 Feb 22.

2 Florida Atlantic University, Boca Raton, FL, USA.

Using a cross-sectional study, this article addresses end-of-life (EOL) care for older Iranian-American adults. The purposes are twofold: (a) to explore participants' preferences for home or hospital care in the event they face EOL conditions and (b) to learn how participants prefer to communicate these preferences. Results showed that about half of the 130 participants had communicated their EOL care preferences through written documents and/or verbal discussions. Read More

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http://dx.doi.org/10.1177/0193945919832304DOI Listing
February 2019

One Component of Whole Health for Our Patients: Connection to Someone With Lived Experience.

Authors:
Gail R Stern

J Am Psychiatr Nurses Assoc 2019 Jan/Feb;25(1):76-77

1 Gail R. Stern, RN, MSN, PMHCNS-BC, American Psychiatric Nurses Association, Falls Church, VA, USA.

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http://dx.doi.org/10.1177/1078390318817721DOI Listing
February 2019

The Psychiatric Mental Health Advanced Practice Registered Nurse Workforce: Charting the Future.

J Am Psychiatr Nurses Assoc 2019 Jan/Feb;25(1):11-18

2 Dawn Vanderhoef, PhD, DNP, PMHNP-BC, FAANP, Vanderbilt University, Nashville, TN, USA.

Aims: To characterize the future Psychiatric Mental Health (PMH) Advanced Practice Registered Nurse (APRN) workforce in light of the high demand for psychiatric providers in all aspects of mental health service delivery. Over the past 20 years, there has been significant growth of the PMH APRN workforce, a provider group capable of addressing mental health provider shortages. However, continued growth may be limited by anticipated retirements and traditional volume of graduations from PMH nurse practitioner (NP) programs. Read More

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http://dx.doi.org/10.1177/1078390318806571DOI Listing
February 2019

[Pediatric Morbidity of a Native American Village in French Guiana (2009-2016)].

Bull Soc Pathol Exot 2018 ;111(3):167-175

Inserm 1424, centre d'investigation clinique Antilles-Guyane, centre hospitalier de Cayenne, av. des Flamboyants, F-97300 Cayenne, Guyane.

The situation of the Amerindian village of Camopi in French Guiana is particular because of its geographical isolation and its socio-cultural environment. Does this unique context affect the morbidity of the children? This study describes the morbidity of children aged 0-5 years in Camopi. The study population included all the children living in Camopi, born between 01/01/2009 and 31/12/2013. Read More

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http://dx.doi.org/10.3166/bspe-2018-0036DOI Listing
January 2018

Associations between an Educational Attainment Polygenic Score with Educational Attainment in an African American Sample.

Genes Brain Behav 2019 Feb 21:e12558. Epub 2019 Feb 21.

Johns Hopkins University Bloomberg School of Public Health, Mental Health, Baltimore, Maryland.

Polygenic propensity for educational attainment has been associated with higher education attendance, academic achievement, and criminal offending in predominantly European samples; however, less is known about whether this polygenic propensity is associated with these outcomes among African Americans. Using an educational attainment polygenic score (EA PGS), the present study examined whether this score was associated with post-secondary education, academic achievement, and criminal offending in an urban, African American sample. Three cohorts of participants (N=1,050; 43. Read More

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http://dx.doi.org/10.1111/gbb.12558DOI Listing
February 2019

Urinary Tract Infections in Solid Organ Transplant Recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

Clin Transplant 2019 Feb 21:e13507. Epub 2019 Feb 21.

Division of Infectious Diseases, Penn State Hershey Medical Center, Hershey, PA, 17033.

These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention and management of urinary tract infections (UTI) in solid organ transplantation, focusing on kidney transplant (KT) recipients. KT recipients have unique risk factors for UTI, including indwelling stents and surgical manipulation of the genitourinary tract. KT recipients experience multidrug antibiotic resistant infections - UTI prevention and management strategies must consider risks of antimicrobial resistance. Read More

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http://dx.doi.org/10.1111/ctr.13507DOI Listing
February 2019

Sensory and Consumer Evaluation of Smoked Pulled Pork Prepared Using Different Smokers and Different Types of Wood.

J Food Sci 2019 Feb 21. Epub 2019 Feb 21.

The Sensory and Consumer Research Center, Kansas State Univ., 22201 W. Innovation Drive, Olathe, KS, 66061, USA.

Smoked and barbecued meats have continued to gain popularity in recent years, however, no consensus exists on the best methods for preparation. Several smoker types and many varieties of wood are used for smoking meat in the restaurant industry and by amateur "pit-masters." In this research, pork was smoked with an outdoor offset smoker and an indoor electric smoker using four wood types: hickory, apple, oak, and mesquite. Read More

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http://dx.doi.org/10.1111/1750-3841.14469DOI Listing
February 2019

Intraocular Pressure in General and Diabetic Populations From Southern China: the Dongguan Eye Study.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):761-769

Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

Purpose: To investigate the distribution and risk factors for intraocular pressure (IOP) among general and diabetic populations in Southern China.

Methods: The study participants aged 40 years or older were enrolled from the Dongguan Eye Study, a population-based cross-sectional study from September 2011 to February 2012. Systemic and ophthalmic examinations were performed, and diabetes status was screened based on the American Diabetes Association diagnostic criteria (2010). Read More

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http://dx.doi.org/10.1167/iovs.18-25247DOI Listing
February 2019

Differences in Genomic Profiles and Outcomes between Thoracic and Adrenal Neuroblastoma.

J Natl Cancer Inst 2019 Feb 21. Epub 2019 Feb 21.

Department of Pediatrics, Childrens Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Background: Neuroblastoma is a biologically and clinically heterogeneous disease. Based on recent studies demonstrating an association between the primary tumor site, prognosis, and commonly measured tumor biological features, we hypothesized that neuroblastomas arising in different sites would show distinct genomic features reflective of the developmental biology of the sympathicoadrenal nervous system.

Methods: We first compared genomic and epigenomic data of primary diagnostic neuroblastomas originating in the adrenal gland (N = 646) compared to thoracic sympathetic ganglia (N = 118). Read More

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http://dx.doi.org/10.1093/jnci/djz027DOI Listing
February 2019

Association of personal vehicle access with lifestyle habits and food insecurity among public housing residents.

Prev Med Rep 2019 Mar 11;13:341-345. Epub 2019 Jan 11.

Division of General Internal Medicine, Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD, USA.

Transportation type may play a role in the ease with which a person can access healthy food and recreation facilities. Our objective was to determine the relationship between access to a personal vehicle and diet, food insecurity, and physical activity among public housing residents, which are typically low-income, urban populations. We conducted a cross-sectional survey of randomly selected households within two public housing communities in Baltimore, MD (2014-2015). Read More

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http://dx.doi.org/10.1016/j.pmedr.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369228PMC

Massive adult cystic lymphangioma of the breast.

J Surg Case Rep 2019 Feb 12;2019(2):rjz027. Epub 2019 Feb 12.

Department of Surgery, Mercy Hospital and Medical Center, Chicago, IL, USA.

Adult cystic lymphangiomas are exceedingly rare tumors resulting from malformation of the lymphatic vessels. Like their pediatric counterparts, these lesions almost exclusively involve the head and neck. However, adult cystic lymphangiomas have been reported in several organs. Read More

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http://dx.doi.org/10.1093/jscr/rjz027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371853PMC
February 2019

Access to high-cost drugs for advanced breast cancer in Latin America, particularly trastuzumab.

Ecancermedicalscience 2019 22;13:898. Epub 2019 Jan 22.

Latin American Cooperative Oncology Group, 99 A, Av Ipiranga 6681, Porto Alegre, RS 90619-900, Brazil.

Provision of high-level healthcare is a challenge for all low- to middle-income countries (LMICs) since healthcare systems are heterogeneous, face many challenges such as inadequate funding, inequitable distribution of resources and services and usually are not adequately equipped to deal with a huge problem such as breast cancer. The development of anti-HER2 therapies can be considered one of the most important examples of the translation of molecular biology knowledge into clinical benefits for cancer patients. While a variety of novel therapeutic strategies are emerging, current treatment regimens remain focussed on targeted therapy with monoclonal antibodies, mainly trastuzumab, the first agent developed in this field. Read More

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http://dx.doi.org/10.3332/ecancer.2019.898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372298PMC
January 2019

Barriers in Latin America for the management of locally advanced breast cancer.

Ecancermedicalscience 2019 22;13:897. Epub 2019 Jan 22.

Departamento de Medicina Oncológica, Oncosalud-AUNA, Lima 15036, Peru.

Breast cancer (BC) is a highly prevalent malignancy in Latin American women, most cases being diagnosed at locally advanced or metastatic stages when options for cancer care are limited. Despite its label as a public health problem in the region, Latin American BC patients face several barriers in accessing standard of care treatment when compared with patients from developed countries. In this review, we analyse the landscape of the four main identified barriers in the region: i) high burden of locally advanced/advanced BC; ii) inadequate access to medical resources; iii) deficient access to specialised cancer care and iv) insufficient BC research in Latin America. Read More

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http://dx.doi.org/10.3332/ecancer.2019.897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372299PMC
January 2019

Precision medicine for locally advanced breast cancer: frontiers and challenges in Latin America.

Ecancermedicalscience 2019 22;13:896. Epub 2019 Jan 22.

Departamento de Medicina Oncológica, Oncosalud-AUNA, Lima 15036, Perú.

Advances in high-throughput technologies and their involvement in the 'omics' of cancer have made possible the identification of hundreds of biomarkers and the development of predictive and prognostic platforms that model the management of cancer from evidence-based medicine to precision medicine. Latin America (LATAM) is a region characterised by fragmented healthcare, high rates of poverty and disparities to access to a basic standard of care not only for cancer but also for other complex diseases. Patients from the public setting cannot afford targeted therapy, the facilities offering genomic platforms are scarce and the use of high-precision radiotherapy is limited to few facilities. Read More

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http://dx.doi.org/10.3332/ecancer.2019.896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372295PMC
January 2019

Locally advanced breast cancer in Brazil: current status and future perspectives.

Ecancermedicalscience 2019 22;13:895. Epub 2019 Jan 22.

Latin American Cooperative Oncology Group, Porto Alegre 90619-900, Brazil.

Breast cancer (BC) is the most frequent cancer and the main cause of cancer deaths among women worldwide and in Brazil. A high proportion of patients are diagnosed with locally advanced breast cancer (LABC) in Brazil, mainly due to limited coverage of screening programmes. A disparity in the access to optimal treatment is evident between the public and private health systems which impact patient outcomes. Read More

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http://dx.doi.org/10.3332/ecancer.2019.895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372296PMC
January 2019

Triple-negative breast cancer: the reality in Chile and in Latin America.

Ecancermedicalscience 2019 22;13:893. Epub 2019 Jan 22.

Oncology Institute Arturo López Pérez Foundation, Santiago 878, Chile.

Breast cancer is the leading cause of cancer death among women worldwide. While triple-negative breast cancer is less common among various sub-types of breast cancer, it tends to affect younger women and is more aggressive, having a higher rate of early recurrence and mortality compared to other sub-types. We know about the association between triple-negative breast cancer and BRCA mutations, which are highly prevalent in founding populations of European origin, but the true prevalence of these mutations in Latin American populations is unknown. Read More

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http://dx.doi.org/10.3332/ecancer.2019.893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372297PMC
January 2019

Interdependent = Compassionate? Compassionate and Self-Image Goals and Their Relationships With Interdependence in the United States and Japan.

Front Psychol 2019 7;10:192. Epub 2019 Feb 7.

Department of Psychology, Ohio State University, Columbus, OH, United States.

The pursuit of compassionate goals, which involves focusing on and attending to other people's needs, has often been described as a defining characteristic of an interdependent self that prioritizes harmonious relationships over individual achievement. This research investigated whether compassionate goals can be empirically distinguished from various indices of interdependence and examined their correlations with interdependence in both American and Japanese adult samples. It further differentiated two types of self-image goals-the goals to appear warm and kind vs. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374305PMC
February 2019

Navigating Networks: How Nonprofit Network Membership Shapes Response to Resource Scarcity.

Authors:
Jennifer W Bouek

Soc Probl 2018 Feb 10;65(1):11-32. Epub 2017 Mar 10.

Brown University.

Central to the contemporary American welfare state, nonprofits are increasingly squeezed between declining resources and a simultaneous peak in demand for services. Scholars have outlined a number of ways that nonprofits strategically respond to resource scarcity. Why nonprofits select particular strategies, however, is less clear. Read More

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http://dx.doi.org/10.1093/socpro/spw048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380674PMC
February 2018

Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours.

Br J Cancer 2019 Feb 22. Epub 2019 Feb 22.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 20 Shattuck Street, Thorn 528, Boston, MA, USA.

Background: Most patients with KIT-mutant gastrointestinal stromal tumours (GISTs) benefit from imatinib, but treatment resistance results from outgrowth of heterogeneous subclones with KIT secondary mutations. Once resistance emerges, targeting KIT with tyrosine kinase inhibitors (TKIs) sunitinib and regorafenib provides clinical benefit, albeit of limited duration.

Methods: We systematically explored GIST resistance mechanisms to KIT-inhibitor TKIs that are either approved or under investigation in clinical trials: the studies draw upon GIST models and clinical trial correlative science. Read More

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http://dx.doi.org/10.1038/s41416-019-0389-6DOI Listing
February 2019

The glial sodium-potassium-2-chloride cotransporter is required for synaptic transmission in the Drosophila visual system.

Sci Rep 2019 Feb 21;9(1):2475. Epub 2019 Feb 21.

Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

The Drosophila Ncc69 gene encodes a Na-K-2Cl-cotransporter (NKCC) that is critical for regulating intra- and extracellular ionic conditions in different tissues. Here, we show that the Ncc69 transporter is necessary for fly vision and that its expression is required non-autonomously in glia to maintain visual synaptic transmission. Flies mutant for Ncc69 exhibit normal photoreceptor depolarization in response to a light pulse but lack the ON and OFF-transients characteristic of postsynaptic responses of lamina neurons, indicating a failure in synaptic transmission. Read More

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http://dx.doi.org/10.1038/s41598-019-38850-xDOI Listing
February 2019

Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME) cohort.

Alzheimers Dement 2019 Feb 12. Epub 2019 Feb 12.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Introduction: Our primary goal was to examine demographic and clinicopathologic differences across an ethnoracially diverse autopsy-confirmed cohort of Alzheimer's disease cases.

Methods: A retrospective study was conducted in the Florida Autopsied Multi-Ethnic cohort on 1625 Alzheimer's disease cases, including decedents who self-reported as Hispanic/Latino (n = 67), black/African American (n = 19), and white/European American (n = 1539).

Results: Hispanic decedents had a higher frequency of family history of cognitive impairment (58%), an earlier age at onset (median age of 70 years), longer disease duration (median of 12 years), and lower MMSE proximal to death (median of 4 points) compared with the other ethnoracial groups. Read More

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http://dx.doi.org/10.1016/j.jalz.2018.12.013DOI Listing
February 2019

Cocaine use is associated with worse outcomes in patients treated with thoracic endovascular repair for type B aortic dissection.

J Vasc Surg 2019 Feb 18. Epub 2019 Feb 18.

Sanger Heart & Vascular Institute, Atrium Health, Charlotte, NC. Electronic address:

Objective: To describe and compare the clinical and anatomical characteristics and outcomes of patients with and without known cocaine use who underwent thoracic endovascular repair for type B aortic dissections.

Methods: Between January 2012 and January 2017, 186 patients underwent thoracic endovascular repair for type B aortic dissection at our institution. Clinical data and anatomical characteristics were collected under an institutional review board-approved protocol. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.10.061DOI Listing
February 2019

Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study.

Am J Geriatr Psychiatry 2019 Jan 7. Epub 2019 Jan 7.

Department of Psychiatry (JLM, SMS, JHK, RHP), Yale University School of Medicine, New Haven, CT; Clinical Neurosciences Division (SMS, JHK, RHP), U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT; Yale School of Public Health (BRL, RHP), New Haven, CT.

Objective: The aim of this study was to identify how a broad range of sociodemographic, military, health, and psychosocial factors relate to accelerated DNA methylation aging (Δ) in a large, contemporary, nationally representative sample of male U.S. veterans. Read More

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http://dx.doi.org/10.1016/j.jagp.2019.01.001DOI Listing
January 2019

The impact of peripheral artery disease on left ventricular diastolic function.

J Cardiol 2019 Feb 18. Epub 2019 Feb 18.

Division of Cardiovascular Medicine and Coronary Heart Disease, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address:

Background: Peripheral artery disease (PAD) is often accompanied by heart failure with preserved ejection fraction (HFpEF). Left ventricular (LV) diastolic dysfunction is related to HFpEF. The aim of this study was to compare LV diastolic function between patients with or without PAD. Read More

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http://dx.doi.org/10.1016/j.jjcc.2019.01.011DOI Listing
February 2019

Prescription of Potentially Harmful Drugs in Young Adults With Heart Failure and Reduced Ejection Fraction.

Am J Cardiol 2019 Feb 10. Epub 2019 Feb 10.

Department of Management, Policy and Community, School of Public Health, University of Texas, Houston, Texas.

According to national guidelines and statements drugs that can cause or exacerbate heart failure (HF) are considered potentially harmful and should be avoided if possible in patients with a diagnosis of heart failure with reduced ejection fraction (HFREF). To evaluate the prevalence of potentially harmful drug (PHD) prescription among patients with a diagnosis of systolic heart failure we conducted a retrospective cohort study using Truven Health MarketScan Commercial database from 2011 to 2014. Prescription of PHD as defined by American Heart Association Statement was examined among patients with a HFREF diagnosis in: (1) Two outpatient encounters, (2) One inpatient encounter as primary diagnosis and/or (3) one inpatient encounter any position and one outpatient encounter. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.052DOI Listing
February 2019

Surgical procedures for treatment of adult acquired flatfoot deformity: a network meta-analysis.

J Orthop Surg Res 2019 Feb 21;14(1):62. Epub 2019 Feb 21.

Department of Orthopedic Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China.

Background: Adult acquired flatfoot deformity (AAFD) represents a spectrum of deformities affecting the foot and the ankle. The optimal management of AAFD remains controversial. We evaluated the efficacy of surgical treatments of AAFD using both direct and indirect evidences. Read More

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http://dx.doi.org/10.1186/s13018-019-1094-0DOI Listing
February 2019

Genomic analyses of an extensive collection of wild and cultivated accessions provide new insights into peach breeding history.

Genome Biol 2019 Feb 21;20(1):36. Epub 2019 Feb 21.

Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, Zhengzhou, China.

Background: Human selection has a long history of transforming crop genomes. Peach (Prunus persica) has undergone more than 5000 years of domestication that led to remarkable changes in a series of agronomically important traits, but genetic bases underlying these changes and the effects of artificial selection on genomic diversity are not well understood.

Results: Here, we report a comprehensive analysis of peach evolution based on genome sequences of 480 wild and cultivated accessions. Read More

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http://dx.doi.org/10.1186/s13059-019-1648-9DOI Listing
February 2019

Sleep oscillation-specific associations with Alzheimer's disease CSF biomarkers: novel roles for sleep spindles and tau.

Mol Neurodegener 2019 Feb 21;14(1):10. Epub 2019 Feb 21.

Department of Psychiatry, NYU School of Medicine, New York, NY, 10016, USA.

Background: Based on associations between sleep spindles, cognition, and sleep-dependent memory processing, here we evaluated potential relationships between levels of CSF Aβ, P-tau, and T-tau with sleep spindle density and other biophysical properties of sleep spindles in a sample of cognitively normal elderly individuals.

Methods: One-night in-lab nocturnal polysomnography (NPSG) and morning to early afternoon CSF collection were performed to measure CSF Aβ, P-tau and T-tau. Seven days of actigraphy were collected to assess habitual total sleep time. Read More

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http://dx.doi.org/10.1186/s13024-019-0309-5DOI Listing
February 2019

Intraarterial Thrombolysis as Rescue Therapy for Large Vessel Occlusions.

Stroke 2019 Feb 22:STROKEAHA118024442. Epub 2019 Feb 22.

St. Vincent Mercy Hospital, Toledo, OH (O.O.Z.).

Background and Purpose- Mechanical thrombectomy (MT) devices have led to improved reperfusion and clinical outcomes in acute ischemic stroke patients with emergent large vessel occlusions; however, less than one-third of patients achieve complete reperfusion. Use of intraarterial thrombolysis in the context of MT may provide an opportunity to enhance these results. Here, we evaluate the use of intraarterial rtPA (recombinant tissue-type plasminogen activator) as rescue therapy (RT) after failed MT in the North American Solitaire Stent-Retriever Acute Stroke registry. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.024442DOI Listing
February 2019