342,315 results match your criteria American Optician[Journal]


A study of the mechanical properties of as-received and intraorally exposed single-crystal and polycrystalline orthodontic ceramic brackets.

Eur J Orthod 2019 Apr 23. Epub 2019 Apr 23.

Clinic of Orthodontics and Pediatric Dentistry, Center of Dental Medicine, University of Zurich, Switzerland.

Background: Although ceramic brackets have been extensively used for decades in orthodontics there is not till today any study focusing on the possible deterioration of mechanical properties after in vivo ageing.

Objectives: To determine whether the mechanical properties of alumina orthodontic brackets change after intraoral ageing thereby assessing the validity of a theoretical model established for the performance of ceramics in wet environments.

Materials And Methods: Two alumina brackets, one single crystal (Radiance, American Orthodontics, Sheboygan, WI) and one polycrystalline (Clarity, 3M, St. Read More

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http://dx.doi.org/10.1093/ejo/cjz024DOI Listing

Indications for Mechanical Thrombectomy Too Wide or Too Narrow?

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

The indications for mechanical thrombectomy (MT) have expanded since the American Heart Association/American Stroke Association (AHA/ASA) published its first guideline on MT in 2013. Multiple subsequent randomized clinical trials of MT have proven its efficacy, including the DAWN and DEFUSE 3 trials. The current guideline from AHA/ASA provides Class I support for the use of MT for the following indications: 1. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.116DOI Listing

Bioethical Issues in Biostatistical Consulting Study: Additional Findings and Concerns.

JDR Clin Trans Res 2019 Apr 22:2380084419837294. Epub 2019 Apr 22.

3 Department of Epidemiology and Health Promotion, College of Dentistry, New York University, New York City, NY, USA.

Objectives: To determine the frequency and severity of 17 requests for inappropriate analysis and reporting of data that biostatisticians received from researchers in statistical consultations, as indirectly experienced (i.e., either heard about or observed being asked of other biostatisticians). Read More

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http://dx.doi.org/10.1177/2380084419837294DOI Listing

A 4-Yr Survey of the Range of Ticks and Tick-Borne Pathogens in the Lehigh Valley Region of Eastern Pennsylvania.

J Med Entomol 2019 Apr 23. Epub 2019 Apr 23.

Suppan LLC, 3870 Kreidersville Road, Northampton, PA.

Questing ticks were surveyed by dragging in forested habitats within the Lehigh Valley region of eastern Pennsylvania for four consecutive summers (2015-2018). A high level of inter-annual variation was found in the density of blacklegged tick nymphs, Ixodes scapularis Say, with a high density of host-seeking nymphs (DON) in summer 2015 and 2017 and a relatively low DON in summer 2016 and 2018. Very few American dog ticks (Dermacentor variabilis Say) and Ixodes cookei Packard were collected. Read More

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http://dx.doi.org/10.1093/jme/tjz043DOI Listing

Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos.

PLoS One 2019 22;14(4):e0215378. Epub 2019 Apr 22.

Institute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, United States of America.

Objective: Hispanics/Latinos have some of the highest prevalence rates for cardiovascular disease risk factors, but stark differences exist by self-reported background. Cardiovascular disease risk factors negatively impact cognition in Hispanics/Latinos; less is known about these relationships by Hispanic/Latino backgrounds. We investigated cognitive associations with cardiovascular disease risk factor burden in a diverse cohort, the Hispanic Community Health Study/Study of Latinos. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215378PLOS
April 2019
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Comment on "US FDA Breast Implant Postapproval Studies: Long-term Outcomes in 99,993 Patients".

Ann Surg 2019 Apr 18. Epub 2019 Apr 18.

Past President, American Society of Plastic Surgeons, Lenox Hill Hospital/Manhattan Eye, Ear, and Throat Hospital, Northwell Health System, Hofstra School of Medicine, New York, NY Past President, American Society for Aesthetic Plastic Surgery, Aesthetic Plastic Surgical Institute, Laguna Beach, CA; Loma Linda University, Loma Linda, CA Past President, American Society for Aesthetic Plastic Surgery, Private Practice, Eugene, OR Loma Linda University Medical Center, Loma Linda, CA.

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http://dx.doi.org/10.1097/SLA.0000000000003293DOI Listing
April 2019
1 Read

Risk Factors and Outcomes for Sepsis after Appendectomy in Adults.

Surg Infect (Larchmt) 2019 Apr 20. Epub 2019 Apr 20.

Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.

Sepsis is an uncommon occurrence after appendectomy, but the morbidity and mortality of patients who develop sepsis after appendectomy remains exceedingly high. The purpose of this study is to identify risk factors and adverse post-operative outcomes associated with sepsis after appendectomy in adults. The American College of Surgery National Surgical Quality Improvement Program participant user database was queried from 2012 to 2015. Read More

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https://www.liebertpub.com/doi/10.1089/sur.2019.003
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http://dx.doi.org/10.1089/sur.2019.003DOI Listing
April 2019
2 Reads

Clinical Factors Associated With Cost in Head and Neck Cancer: Implications for a Bundled Payment Model.

J Oncol Pract 2019 Apr 22:JOP1800665. Epub 2019 Apr 22.

3 Levine Cancer Institute, Atrium Health, Charlotte, NC.

Purpose: To determine which factors influence cost in head and neck cancer (HNC) to inform the development of a bundled payment model (BPM).

Methods: Patients with stages 0 to IVB (by American Joint Commission on Cancer, 7th edition) HNC of various sites and histology treated definitively at a single tertiary care center during 2013 were included. Clinical variables and direct cost data were obtained, and their associations were investigated using χ, , Wilcoxon rank sum, and analysis of variance testing. Read More

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http://dx.doi.org/10.1200/JOP.18.00665DOI Listing

Identifying Gaps in Frontline Healthcare Facility High-Consequence Infectious Disease Preparedness.

Health Secur 2019 Mar/Apr;17(2):117-123

Saskia Popescu, MPH, MA, is an Infection Preventionist and Research Assistant, George Mason University, Fairfax, Virginia. Rebecca Leach, MPH, RN, is an Infection Preventionist, Phoenix, Arizona.

Hospital infection disease preparedness gaps were brought to the forefront during the 2013-2016 Ebola virus disease (EVD) outbreak. The ability of US hospitals to rapidly identify, isolate, and manage patients with potentially high-consequence pathogens is a critical component to health security. Since the EVD cases in Dallas, Texas, the continuity of hospital preparedness has been questionable. Read More

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https://www.liebertpub.com/doi/10.1089/hs.2018.0098
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http://dx.doi.org/10.1089/hs.2018.0098DOI Listing
April 2019
1 Read

American Nephrology Nurses Association - Celebrating 50 Years!

Authors:
Beth Ulrich

Nephrol Nurs J 2019 Mar-Apr;46(2):93

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Next generation of dentists moving to amalgam-free dentistry: survey of posterior restorations teaching in North America.

Eur J Dent Educ 2019 Apr 22. Epub 2019 Apr 22.

Department of Prosthodontics, The Hebrew University-Hadassah, Faculty of Dental Medicine, Jerusalem, Israel.

Objectives: The dental field is gradually reducing the use of amalgam and moving toward adhesive restoration. This change is in accordance with the advancement and improvement of composite resin materials and adhesion systems. Consequently, posterior cavity preparations teaching should be re-examined to determine whether dental schools are adapting their curriculum to fit the current trends in dentistry and what rationale supports their decisions. Read More

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http://dx.doi.org/10.1111/eje.12437DOI Listing

Dataset for reporting of carcinoma of the urethra (in urethrectomy specimens): recommendations from the International Collaboration on Cancer Reporting (ICCR).

Histopathology 2019 Apr 22. Epub 2019 Apr 22.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, IUH Pathology Laboratory, Indianapolis, IN, USA.

Aims: The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation sponsored by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Association of Pathologists in association with the Canadian Partnership Against Cancer, the European Society of Pathology, the American Society of Clinical Pathology and the Faculty of Pathology, Royal College of Physicians of Ireland. Its goal is to produce standardized, internationally agreed upon, evidence-based datasets for cancer pathology reporting throughout the world.

Methods And Results: This paper describes the development of a cancer dataset by the multidisciplinary ICCR expert panel for the reporting of carcinoma of the urethra in urethrectomy specimens. Read More

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http://dx.doi.org/10.1111/his.13877DOI Listing

Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease.

JAMA Neurol 2019 Apr 22. Epub 2019 Apr 22.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

Importance: Plasma neurofilament light (NfL) has been suggested as a noninvasive biomarker to monitor neurodegeneration in Alzheimer disease (AD), but studies are lacking.

Objective: To examine whether longitudinal plasma NfL levels are associated with other hallmarks of AD.

Design, Setting, And Participants: This North American cohort study used data from 1583 individuals in the multicenter Alzheimer's Disease Neuroimaging Initiative study from September 7, 2005, through June 16, 2016. Read More

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http://dx.doi.org/10.1001/jamaneurol.2019.0765DOI Listing

Cardiac implantable electronic device infections: Observational data from a tertiary care center in Lebanon.

Medicine (Baltimore) 2019 Apr;98(16):e14906

Department of Internal Medicine, Division of Infectious Diseases, American University of Beirut Medical Center, Lebanon.

With increasing rates of device implantation, there is an increased recognition of device infection. We conducted a retrospective observational study in a tertiary care center in Lebanon, with data collected from medical records of patients presenting with cardiac implantable electronic device (CIED) infection from 2000 to 2017 with the purpose of identifying etiologies, risk factors and other parameters, and comparing them to available data from the rest of the world. We identified a total of 22 CIED infections. Read More

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http://dx.doi.org/10.1097/MD.0000000000014906DOI Listing

Framework for the Creation of Ethical and Professional Social Media Content.

Plast Reconstr Surg 2019 Apr 15. Epub 2019 Apr 15.

Oklahoma City, Oklahoma.

Background: Social Media is a powerful tool that allows users to communicate directly with an online community. Plastic surgeons were early adopters of social media, recognizing its educational and marketing potential. With the use of social media come ethical and legal concerns. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005782DOI Listing

Between the Error Bars: How Modern Theory, Design, and Methodology Enrich the Personality-Health Tradition.

Psychosom Med 2019 Apr 18. Epub 2019 Apr 18.

Department of Psychology University of Kentucky 125 Kastle Hall Lexington, KY 40506-0044

The study of relationships between personality traits and health has a long history in psychosomatic research. However, personality science has evolved from an understanding of personality as fixed traits to one that acknowledges that personality is dynamic. Dynamic approaches to conceptualizing and measuring personality and individual differences can enrich personality-health research. Read More

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http://dx.doi.org/10.1097/PSY.0000000000000701DOI Listing

Chemotherapy-induced peripheral neuropathy: where are we now?

Authors:
Lesley A Colvin

Pain 2019 May;160 Suppl 1:S1-S10

Chair of Pain Medicine, Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland.

Chemotherapy-induced peripheral neuropathy (CIPN) is a major challenge, with increasing impact as oncological treatments, using potentially neurotoxic chemotherapy, improve cancer cure and survival. Acute CIPN occurs during chemotherapy, sometimes requiring dose reduction or cessation, impacting on survival. Around 30% of patients will still have CIPN a year, or more, after finishing chemotherapy. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001540DOI Listing

The DNP Degree: Are We Producing the Graduates We Intended?

J Nurs Adm 2019 May;49(5):280-285

Author Affiliations: Associate Professor (Dr Bowie), Professor (Dr DeSocio), Dean (Dr Swanson), Seattle University, College of Nursing, Washington.

Objective: This study addressed how recently graduated doctor of nursing practice (DNP) nurses describe their current practice, how their supervisors describe the DNP's current practice, and whether nurse and supervisor descriptions of the practices reflect the American Association of Colleges of Nursing (AACN) DNP Essentials and, if so, how?

Background: Introduced in 2004, the goal of DNP programs was to educate advanced practice RNs for effective leadership in complex healthcare environments. The value of the DNP degree for nurses in healthcare systems is evolving.

Methods: We used conventional content analysis to inductively describe how DNP graduates from 7 different schools and their supervisors described the practice of the recently graduated DNPs. Read More

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http://dx.doi.org/10.1097/NNA.0000000000000751DOI Listing
May 2019
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Prevent Compassion Fatigue and Burnout With a Magnet Culture.

J Nurs Adm 2019 May;49(5):231-233

Author Affiliation: Vice President, Magnet Recognition Program® and Pathway to Excellence Program®, American Nurses Credentialing Center, Silver Spring, Maryland.

Compassion fatigue and burnout are 2 of the most serious issues facing the nursing profession today. Both can lead to emotional exhaustion and job disillusionment. Both contribute to lowered productivity and quality of care. Read More

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http://dx.doi.org/10.1097/NNA.0000000000000743DOI Listing
May 2019
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Hospital risk-based payments and physician employment: Impact on financial performance.

Authors:
Gloria J Bazzoli

Health Care Manage Rev 2019 Apr 17. Epub 2019 Apr 17.

Gloria J. Bazzoli, PhD, is Bon Secours Professor, Department of Health Administration, College of Health Professions, Virginia Commonwealth University, Richmond. E-mail:

Background: Hospital involvement in risk-based payment and employment of physicians can have a large impact on their profitability. Risk-based reimbursement approaches with third-party payers and provider-sponsored insurance products hold hospital organizations financially accountable for a range of patient services. Direct employment of physicians can add new revenue sources for the hospital but comes at the high cost of physician compensation packages. Read More

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http://dx.doi.org/10.1097/HMR.0000000000000245DOI Listing

The Preventive Role of ACE Inhibitors/Angiotensin-II Receptor Blockers and β-Adrenergic Blockers in Anthracycline and Trastuzumab-Induced Cardiotoxicity.

Cardiol Rev 2019 Apr 12. Epub 2019 Apr 12.

New York Medical College/Westchester Medical Center, Valhalla, NY.

Anthracycline (doxorubicin) and trastuzumab treatments for cancer patients have been known to cause cardiotoxicity. The current recommendations for prevention of cardiac events from cancer chemotherapies are largely based on opinion. The American Society of Clinical Oncology recommends active screening and prevention of modifiable cardiovascular risk factors. Read More

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http://dx.doi.org/10.1097/CRD.0000000000000252DOI Listing

Effects of Dexmedetomidine on Blood Glucose and Serum Potassium Levels in Children Undergoing General Anesthesia: A Secondary Analysis of Safety Endpoints During a Randomized Controlled Trial.

Anesth Analg 2019 Apr 16. Epub 2019 Apr 16.

From the Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.

Background: Dexmedetomidine is a highly selective α2-adrenergic agonist, which is increasingly used in pediatric anesthesia and intensive care. Potential adverse effects that have not been rigorously evaluated in children include its effects on blood glucose and serum potassium concentrations, which are relevant due to the associations of derangements of both parameters with undesired outcomes. We investigated the effects of 3 different doses of dexmedetomidine on these outcomes in a randomized controlled trial in children undergoing elective surgery. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004154DOI Listing
April 2019
1 Read

The Effect of Vitamin D Supplements on Clinical and Para-Clinical Outcomes in Patients With Multiple Sclerosis: Protocol for a Systematic Review.

JMIR Res Protoc 2019 Apr 22;8(4):e12045. Epub 2019 Apr 22.

Bristol-Myers Squibb, Uxbridge, United Kingdom.

Background: Multiple sclerosis (MS) is an inflammatory disease, which has a wide range of effects on patients. There are controversies regarding the role of vitamin D in clinical and laboratory improvements in MS patients.

Objective: The aim of this systematic review protocol is to evaluate the efficacy of vitamin D supplements on relapse rate, gadolinium-enhancing lesions of magnetic resonance imaging (MRI), and cytokine profiles. Read More

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http://dx.doi.org/10.2196/12045DOI Listing

PPAR-δ Activation Ameliorates Diabetes-Induced Cognitive Dysfunction by Modulating Integrin-linked Kinase and AMPA Receptor Function.

J Am Coll Nutr 2019 Apr 22:1-10. Epub 2019 Apr 22.

a Department of Drug Discovery and Development, Harrison School of Pharmacy , Auburn University , Auburn , Alabama , USA.

An estimated 9% of the American population experiences type II diabetes mellitus (T2DM) due to diet or genetic predisposition. Recent reports indicate that patients with T2DM are at increased risk for cognitive dysfunctions, as observed in conditions like Alzheimer's disease (AD). In addition, AD is the leading cause of dementia, highlighting the urgency of developing novel therapeutic targets for T2DM-induced cognitive deficits. Read More

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http://dx.doi.org/10.1080/07315724.2019.1598307DOI Listing

Distress tolerance trajectories following substance use treatment.

J Consult Clin Psychol 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill.

Objective: Distress tolerance (DT), the ability to withstand aversive internal states, represents an important risk factor for substance use relapse and a potential treatment target. Neurobiological research in substance using populations suggests that continued substance use could erode DT, whereas abstinence could bolster it. The current study characterized trajectories of behavioral and self-reported indices of DT and examined the prospective effect of substance use on DT trajectories among those seeking treatment for substance use. Read More

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http://dx.doi.org/10.1037/ccp0000403DOI Listing

Examining race as a predictor and moderator of treatment outcomes for binge-eating disorder: Analysis of aggregated randomized controlled trials.

J Consult Clin Psychol 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychiatry, School of Medicine, Yale University.

Objective: To examine whether race predicted or moderated response to treatments for binge-eating disorder (BED).

Method: Participants were 592 adults (n = 113 Black; n = 479 White) with DSM-IV-defined BED who participated in randomized controlled trials (RCTs) at 1 medical center. Data were aggregated from RCTs for BED testing cognitive-behavioral therapy, behavioral weight loss, multimodal treatment, and/or control conditions. Read More

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http://dx.doi.org/10.1037/ccp0000404DOI Listing

Relationships and responsiveness in the psychological treatment of trauma: The tragedy of the APA clinical practice guideline.

Psychotherapy (Chic) 2019 Apr 22. Epub 2019 Apr 22.

Department of Counseling Psychology, University of Wisconsin-Madison.

The therapeutic relationship and responsiveness/treatment adaptations rightfully occupy a prominent, evidence-based place in any guidelines for the psychological treatment of trauma. In this light, we critique the misguided efforts of the American Psychological Association's (APA, 2017) Clinical Practice Guideline on Posttraumatic Stress Disorder in Adults to advance a biomedical model for psychotherapy and thus focus almost exclusively on treatment methods for particular disorders. Instead, the research evidence, clinical expertise, and patient preferences and culture (the necessary triumvirate of evidence-based practice) should converge on distinctive psychological guidelines that emphasize the therapy relationship, treatment adaptations, and individual therapist effects, all of which independently account for patient improvement more than the particular treatment method. Read More

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http://dx.doi.org/10.1037/pst0000228DOI Listing

Visualization of the intrarenal distribution of capillary blood flow.

Physiol Rep 2019 Apr;7(8):e14065

Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.

This study describes a modified technique to fill the renal vasculature with a silicon rubber (Microfil) compound and obtain morphologic information about the intrarenal distribution of capillary blood flow under a variety of conditions. Kidneys and cremaster muscles of rats were perfused in vivo with Microfil using a perfusion pressure equal to the animal's mean arterial pressure at body temperature. Microfil did not alter arteriolar diameter or the pattern of flow in the microcirculation of the cremaster muscle. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.14814/phy2.14065
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http://dx.doi.org/10.14814/phy2.14065DOI Listing
April 2019
1 Read

Joint linkage and association mapping of complex traits in shrub willow (Salix purpurea L.).

Ann Bot 2019 Apr 22. Epub 2019 Apr 22.

Horticulture Section, School of Integrative Plant Science, Cornell University, Cornell AgriTech, Geneva, NY, USA.

Background And Aims: Increasing energy demands and the necessity to reduce greenhouse gas emissions are key motivating factors driving the development of lignocellulosic crops as an alternative to non-renewable energy sources. The effects of global climate change will require a better understanding of the genetic basis of complex adaptive traits to breed more resilient bioenergy feedstocks, like willow (Salix spp.). Read More

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http://dx.doi.org/10.1093/aob/mcz047DOI Listing

Clinical efficacy of collateral circulation in the evaluation of endovascular treatment for acute internal carotid artery occlusion.

Heliyon 2019 Apr 8;5(4):e01476. Epub 2019 Apr 8.

Department of Neurology, People's Hospital of Linyi, Linyi, Shandong, China.

Objectives: Despite successful recanalization, there remain many patients suffering bad outcome after endovascular treatment, especially for occlusion at the distal portion of internal carotid artery. The goal of the current study was to investigate the value of collateral circulation in predicting malignant events after endovascular treatment in acute ischemic stroke-terminal internal carotid artery (AIS-TICA) patients.

Methods: The records of forty-one patients with AIS-TICA as confirmed by digital subtraction angiography and subjected to mechanical thrombectomy were reviewed. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458472PMC

Atmospheric levels of BPA associated with particulate matter in an urban environment.

Heliyon 2019 Apr 8;5(4):e01419. Epub 2019 Apr 8.

Instituto Multidisciplinario de Biología Vegetal, CONICET and FCEFyN, Universidad Nacional de Córdoba, Av. Vélez Sarsfield 1611, X5016 GCA Córdoba, Argentina.

Bisphenol A (BPA) is an Endocrine disruptor compound (EDC), capable of interfering with hormone related pathways and cause adverse effects, for example, in the reproductive system in wildlife and humans. As it has multiple applications and uses, mainly in the manufacturing of plastic and resin products, increasing amounts are being released into the environment with resulting enhanced exposure pathways. Since negative effects have been demonstrated even at low doses, it has been increasingly studied. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454204PMC

Frequency of Workplace Burnout Among Postgraduate Trainees in a Teaching Hospital in Mirpur.

Cureus 2019 Feb 5;11(2):e4016. Epub 2019 Feb 5.

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.

Background: Work-related stress and burnout among medical practitioners has been a frequently studied phenomenon. It reduces work efficiency and productivity and also has negative impacts on patient care. This study assessed the extent of work-related stress and burnout and the reasons behind this burnout among the Internal Medicine and Pulmonology residents of Mirpur, Azad Kashmir. Read More

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http://dx.doi.org/10.7759/cureus.4016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453621PMC
February 2019

Treatment According to Molecular Profiling in Relapsed/Refractory Cancer Patients: A Review Focusing on Latest Profiling Studies.

Comput Struct Biotechnol J 2019 26;17:447-453. Epub 2019 Mar 26.

Department of Haematology and Oncology, Medical University of Innsbruck, Austria.

In this review we aim to summarize studies investigating the impact of a molecular profiling (MP)-guided treatment approach in heavily pretreated cancer patients. In summary, many independent single- and multicenter studies showed a significant benefit of MP-guided treatment regarding response rates and survival. However, in the only randomized trial conducted so far, no benefit of MP-guided targeted therapy was observed. Read More

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http://dx.doi.org/10.1016/j.csbj.2019.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453774PMC

Association of preoperative systemic corticosteroid therapy with surgical outcomes in chronic obstructive pulmonary disease patients.

Ann Thorac Med 2019 Apr-Jun;14(2):141-147

Department of Internal Medicine, American University of Beirut Medical Center, Lebanon, USA.

Background: Chronic obstructive pulmonary disease (COPD) patients are at an increased risk of postoperative pulmonary complications (PPCs). The purpose of this study is to evaluate the risks and benefits associated with preoperative steroids in COPD patients.

Methods: The National Surgical Quality Improved Program database was used to identify 92 COPD patients who underwent surgery at the American University of Beirut Medical Center between 2009 and 2013. Read More

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http://dx.doi.org/10.4103/atm.ATM_245_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467015PMC

Treatment outcomes of the posterolateral approach of plate fixation for posterior pilon fractures.

Exp Ther Med 2019 May 1;17(5):4267-4272. Epub 2019 Apr 1.

Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, P.R. China.

Posterior pilon fracture is a common type of intraarticular fracture encountered in clinical practice. The treatment of this fracture pattern has been increasingly reported. However, methods for minimizing the associated surgical trauma and achieve effective fixation still require to be established. Read More

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http://dx.doi.org/10.3892/etm.2019.7458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468327PMC

Correction to: Eosinophilic esophagitis.

Allergy Asthma Clin Immunol 2019 10;15:22. Epub 2019 Apr 10.

4Division of Allergy, Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, NS Canada.

[This corrects the article DOI: 10.1186/s13223-018-0287-0.]. Read More

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http://dx.doi.org/10.1186/s13223-019-0336-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456987PMC

Perioperative lidocaine in ambulatory surgery: A useful addition.

Authors:
Abhijit S Nair

Saudi J Anaesth 2019 Apr-Jun;13(2):150-151

Department of Anaesthesiology, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.

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http://dx.doi.org/10.4103/sja.SJA_629_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448432PMC

Dexmedetomidine versus fentanyl added to bupivacaine for epidural analgesia in combination with general anesthesia for elective lumbar disc operations: A prospective, randomized double-blinded study.

Saudi J Anaesth 2019 Apr-Jun;13(2):119-125

Department of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Background: The literature on drugs used for combined general anesthesia and epidural analgesia (CGE) in lumbar operations is scarce. The purpose of the study was to compare the addition of either dexmedetomidine or fentanyl to bupivacaine for epidural analgesia in combination with general anesthesia with regard to efficacy and adverse events in such operations.

Materials And Methods: This prospective, randomized, double-blinded study was conducted on 80 patients who were scheduled for an elective lumbar disc operation, age 20-65 years, of either sex and American Society of Anesthesiologists physical status I or II. Read More

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http://dx.doi.org/10.4103/sja.SJA_600_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448444PMC

Virulence factor RNA transcript expression in the subgenus: influence of species, isolate source, and RNA virus-1.

Trop Med Health 2019 11;47:25. Epub 2019 Apr 11.

1Institute of Medical Sciences, University of Toronto, Toronto, ON Canada.

Background: RNA virus-1 (LRV1) is a double-stranded RNA virus identified in 20-25% of -species endemic to Latin America, and is believed to accelerate cutaneous to mucosal leishmaniasis over time. Our objective was to quantify known virulence factor (VF) RNA transcript expression according to LRV1 status, causative species, and isolate source.

Methods: Eight cultured isolates of were used, four of which were LRV1-positive ( [ = 1], . Read More

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http://dx.doi.org/10.1186/s41182-019-0153-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458769PMC

Evaluation of Oxidative Stress and Severity of Endometriosis.

J Hum Reprod Sci 2019 Jan-Mar;12(1):40-46

Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Aims: The aim was to evaluate the association between oxidative stress with the severity of endometriosis in blood and peritoneal fluid.

Settings And Design: This study was a prospective observational study conducted in the department of obstetrics and gynecology in a tertiary center over 2 years in patients with endometriosis requiring laparoscopy.

Methodology: Patients diagnosed with endometriosis and undergoing laparoscopy for infertility and/or chronic pelvic pain were included in the study. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_27_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472204PMC

Trends in obesity prevalence among total hip arthroplasty patients and the effect on surgical outcomes, 2008-2016.

J Orthop 2019 Jul-Aug;16(4):347-352. Epub 2019 Apr 7.

Chief of Orthopaedic Surgery at Pennsylvania Hospital, Assistant Professor of Orthopaedic Surgery, Department of Orthopaedic Surgery University of Pennsylvania, 800 Spruce Street, 8th Floor Preston Building, Philadelphia, PA, 19107, USA.

Introduction: The prevalence of obesity continues to rise in parallel with demand for total hip arthroplasty (THA). This study aims to report obesity trends in primary THA and its effects on procedure outcomes in the United States, stratifying based on Body Mass Index (BMI).

Methods: Primary THA procedures were identified in the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database (2008-2016). Read More

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http://dx.doi.org/10.1016/j.jor.2019.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458338PMC

Evaluation of the effect and safety of dexmedetomidine as an additive to local anesthesia in peribulbar block for vitreoretinal surgery.

Indian J Ophthalmol 2019 May;67(5):636-640

Department of Vitreoretina, Dr. Shroff's Charity Eye Hospital, New Delhi, India.

Purpose: We conducted a prospective, randomized study to evaluate the efficacy of dexmedetomidine as an additive to peribulbar block for vitreoretinal surgery in terms of onset time of block, hemodynamic stability profile, patient comfort, and surgeon satisfaction.

Methods: One hundred patients of American Society of Anesthesiologists grade 1 and 2 scheduled for vitreoretinal surgery were randomly assigned into two groups: control group (n = 50) received lignocaine bupivacaine block, and Dex group (n = 50) received lignocaine bupivacaine plus 20 μg dexmedetomidine peribulbar block. Information regarding time for onset of block, hemodynamic data, visual analog scale for pain, sedation levels, total duration of surgery, and surgeon satisfaction levels were collected. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1386_18DOI Listing

Impact of the HealthMatters Train-the-Trainer Program on the Health and Health Behaviors of Staff Supporting Adults With Intellectual and Developmental Disabilities.

Workplace Health Saf 2019 Apr 21:2165079919828739. Epub 2019 Apr 21.

3 American College of Surgeons.

The health status and health behaviors among support staff providing daily support for people with intellectual and developmental disabilities (IDD-SS) in community-based organizations (CBOs) have not been systematically studied. This study examined the health impact of IDD-SS workers who participated in a HealthMatters Program: Train-the-Trainer Certified Instructor Workshop followed by implementing a 12-week HealthMatters Program for people with intellectual and developmental disabilities (IDD) that they care for as part of their employment. A total of 48 IDD-SS were enrolled into either an intervention ( n = 28) or control group ( n = 20). Read More

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http://dx.doi.org/10.1177/2165079919828739DOI Listing

Association of pneumonia, wound infection and sepsis with clinical outcomes after acute traumatic spinal cord injury.

J Neurotrauma 2019 Apr 22. Epub 2019 Apr 22.

St. Michael's Hospital, Division of Neurosurgery, Toronto, Canada ;

Pneumonia, wound infections and sepsis (PWS) are the leading causes of acute mortality after traumatic spinal cord injury (SCI). However, the impact of PWS on neurological and functional outcomes is largely unknown. The present study analysed participants from the prospective North American Clinical Trials Network (NACTN) registry and the Surgical Timing in Acute SCI Study (STASCIS) for the association between PWS and functional outcome (assessed as Spinal Cord Independence Measure subscores for respiration and indoor ambulation) at 6 months postinjury. Read More

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http://dx.doi.org/10.1089/neu.2018.6245DOI Listing

Results of the Workplace Health in America Survey.

Am J Health Promot 2019 Apr 22:890117119842047. Epub 2019 Apr 22.

1 Department of Health Behavior, UNC Gillings School of Global Public Health, Chapel Hill, NC, USA.

Purpose: To provide a nationally representative snapshot of workplace health promotion (WHP) and protection practices among United States worksites.

Design: Cross-sectional, self-report Workplace Health in America (WHA) Survey between November 2016 and September 2017.

Setting: National. Read More

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http://dx.doi.org/10.1177/0890117119842047DOI Listing
April 2019
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Progesterone pretreatment reduces the incidence of drug-induced torsades de pointes in atrioventricular node-ablated isolated perfused rabbit hearts.

J Cardiovasc Electrophysiol 2019 Apr 21. Epub 2019 Apr 21.

Department of Medicine, Krannert Institute of Cardiology, School of Medicine, Indiana University, Indianapolis, Indiana.

Introduction: Higher progesterone concentrations are protective against drug-induced prolongation of ventricular repolarization. We tested the hypothesis that pretreatment with progesterone reduces the incidence of drug-induced torsades de pointes (TdP).

Methods And Results: Female New Zealand white rabbits (2. Read More

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http://dx.doi.org/10.1111/jce.13942DOI Listing

Prediction of adverse perinatal outcomes by fetal biometry: a comparison of customized and population-based standards.

Ultrasound Obstet Gynecol 2019 Apr 22. Epub 2019 Apr 22.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS).

Objective: To compare the predictive ability of estimated fetal weight (EFW) percentiles, according to seven growth standards, to detect fetuses at risk for adverse perinatal outcomes.

Methods: This retrospective cohort study included 3,437 African-American women. Population-based (Hadlock, INTERGROWTH-21st, WHO, FMF), ethnic specific (NICHD), customized (GROW) and African American customized (PRB/NICHD) growth standards were applied to the last available scan prior to delivery. Read More

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http://dx.doi.org/10.1002/uog.20299DOI Listing

Correlates, Trends, and Short-Term Outcomes of Venous Thromboembolism in Hospitalized Patients with Hepatocellular Carcinoma.

J Gastrointest Cancer 2019 Apr 22. Epub 2019 Apr 22.

Division of Gastroenterology and Hepatology, Saint Louis University, St Louis, MO, USA.

Background And Aim: The incidence and overall mortality of hepatocellular carcinoma (HCC) in the US have been increasing over the past decade. Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in cancer patients. This study aims at examining the epidemiology, risk factors, and short-term outcomes of VTE in hospitalized patients with HCC. Read More

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http://dx.doi.org/10.1007/s12029-019-00242-9DOI Listing

Clinico-pathologic and mammographic characteristics of inflammatory and non-inflammatory breast cancer at six centers in North Africa.

Breast Cancer Res Treat 2019 Apr 22. Epub 2019 Apr 22.

Medical School of the City University of New York, New York, NY, USA.

Purpose: We describe the clinico-pathologic and mammographic characteristics of inflammatory breast cancer (IBC) and non-IBC cases enrolled in a case-control study. Because IBC is a clinico-pathologic entity with rapid appearance of erythema and other signs, its diagnosis is based on clinical observation and thus, by necessity, subjective. Therefore, we evaluate our cases by photographic review by outside expert clinicians and by degree of adherence to the two most recent definitions of IBC: the international expert panel consensus statement and American Joint Committee on Cancer (AJCC) 8th edition (we used the slightly less restrictive 7th edition definition for our study). Read More

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http://dx.doi.org/10.1007/s10549-019-05237-5DOI Listing

Multi-center evaluation of oxidation-reduction potential by the MiOXSYS in males with abnormal semen.

Asian J Androl 2019 Apr 16. Epub 2019 Apr 16.

Tulane University, New Orleans, LA 70118, USA.

According to the World Health Organization (WHO), oxidative stress (OS) is a significant contributor to male infertility. Seminal OS can be measured by a number of assays, all of which are either costly or time sensitive and/or require large semen volume and complex instrumentation. One less expensive alternative is to quantify the oxidation-reduction potential (ORP) with the MiOXSYS. Read More

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http://dx.doi.org/10.4103/aja.aja_5_19DOI Listing