396,436 results match your criteria American Mathematical Monthly[Journal]

Dairy foods, calcium, and risk of breast cancer overall and for subtypes defined by estrogen receptor status: a pooled analysis of 21 cohort studies.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Background: Epidemiologic studies examining the relations between dairy product and calcium intakes and breast cancer have been inconclusive, especially for tumor subtypes.

Objective: To evaluate the associations between intakes of specific dairy products and calcium and risk of breast cancer overall and for subtypes defined by estrogen receptor (ER) status.

Method: We pooled the individual-level data of over 1 million women who were followed for a maximum of 8-20 years across studies. Read More

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Discordance in Appendicitis Grading and the Association with Outcomes: A Post-Hoc Analysis of an EAST Multicenter Study.

J Surg Res 2021 May 5;265:259-264. Epub 2021 May 5.

Division of Trauma and Surgical Critical Care, DeWitt Daughtry Family Department of Surgery, Jackson Memorial Hospital, University of Miami Miller School of Medicine, Miami, Florida.

Background: The American Association for the Surgery of Trauma (AAST) appendicitis severity grading criteria use independent subscales for radiologists (Rad), surgeons (Surg), and pathologists (Path). We reviewed the EAST Multicenter Study of the Treatment of Appendicitis in America: Acute, Perforated, and Gangrenous (MUSTANG) database to determine rates of discordance and clinical consequences of inaccuracy.

Materials And Methods: A confusion matrix was constructed for pairs among Rad, Surg, and Path. Read More

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Differential DNA Methylation is associated with Hippocampal Abnormalities in Pediatric Posttraumatic Stress Disorder.

Biol Psychiatry Cogn Neurosci Neuroimaging 2021 May 5. Epub 2021 May 5.

Department of Child and Adolescent Psychiatry, The Netherlands; De Bascule, Academic Centre for Child and Adolescent Psychiatry, Amsterdam, The Netherlands.

Background: Recent findings in neuroimaging and epigenetics offer important insights into brain structures and biological pathways of altered gene expression associated with posttraumatic stress disorder (PTSD). However, it is unknown to what extent epigenetic mechanisms are associated with PTSD and its neurobiology in youth.

Methods: In this study we combined a methylome-wide association study and structural neuroimaging measures in a Dutch cohort of youth with PTSD (ages 8-18 years). Read More

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MUSIC INTERVENTIONS IN PEDIATRIC ONCOLOGY: systematic review and meta-analysis.

Complement Ther Med 2021 May 5:102725. Epub 2021 May 5.

Pediatrics Department of the University of São Paulo, Av. Dr Enéas Carvalho Aguiar No. 647, Cerqueira Cesar, São Paulo, CEP: 05403-901, Brazil. Electronic address:

Background: Pain is a disagreeable and distressing feeling that affects human beings in multi-dimensional ways. A number of non-pharmacological interventions have had varying degrees of success in treating cancer-related pain, such as breathing and relaxation techniques, and music therapy, which have been identified as beneficial therapies for alleviating pain and anxiety.

Objective: Identify the therapeutic effects of music interventions in psychological and physiological terms and on the quality of life of children undergoing cancer treatment. Read More

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The inverse relationship between labral size and acetabular coverage: Does it protect the cartilage in the dysplastic hip?

Arthroscopy 2021 May 5. Epub 2021 May 5.

American Hip Institute Research Foundation, Chicago, IL 60018; American Hip Institute, Chicago, IL 60018; AMITA Health St. Alexius Medical Center, Hoffman Estates, IL 60169. Electronic address:

Purpose: The aims of this study were to confirm the relationship between osseous coverage and labral size, and to investigate the severity of intra-articular damage in borderline dysplastic hips in correlation to labral size.

Methods: Patients treated with primary hip arthroscopy for symptomatic labral tears between 2010 and 2018 were considered for this study. Patients were included if they had preoperative radiographic measures and intraoperative assessments of the labra and cartilage. Read More

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Pediatric Asthma Incidence Rates in the United States from 1980-2017.

J Allergy Clin Immunol 2021 May 5. Epub 2021 May 5.

Background: Few studies have examined longitudinal asthma incidence rates from a public health surveillance perspective.

Objective: Calculate descriptive asthma incidence rates in children over time considering demographics and parental asthma history.

Methods: Data from nine US birth cohorts were pooled into one population covering 1980-2017. Read More

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Is Outpatient Management of Mandibular Fractures Associated With Inflammatory Complications? An ACS-NSQIP Study.

J Oral Maxillofac Surg 2021 Mar 26. Epub 2021 Mar 26.

Assistant Professor, Oral & Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA. Electronic address:

Purpose: Timing of mandibular fracture repair has long been debated. The purpose of the present study was to assess the incidence of postoperative inflammatory complications (POICs) following open repair of mandibular fractures managed non-urgently in the outpatient setting versus urgently in the inpatient setting.

Methods: The authors utilized the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database to enroll a sample of patients with mandibular fractures who underwent open repair. Read More

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Identifying urban hotspots of dengue, chikungunya, and Zika transmission in Mexico to support risk stratification efforts: a spatial analysis.

Lancet Planet Health 2021 May;5(5):e277-e285

Department of Environmental Sciences, Emory University, Atlanta, GA, USA. Electronic address:

Background: Effective Aedes aegypti control is limited, in part, by the difficulty in achieving sufficient intervention coverage. To maximise the effect of vector control, areas with persistently high numbers of Aedes-borne disease cases could be identified and prioritised for preventive interventions. We aimed to identify persistent Aedes-borne disease hotspots in cities across southern Mexico. Read More

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Pre-incision Adjunctive Prophylaxis for Cesarean Sections: A Systematic Review and Meta-analysis.

Am J Obstet Gynecol 2021 May 5. Epub 2021 May 5.

ObGyn & Women's Health Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195. Electronic address:

Objective: To systematically review the relative effectiveness of pre-incision cefazolin with or without adjunctive prophylaxis (macrolides or metronidazole), versus cefazolin alone, in decreasing the incidence of post-Cesarean surgical site infections.

Data Sources: We performed a systematic search of PubMed, Ovid EMBASE, Google Scholar, ClinicalTrials.gov and Cochrane Central Register of Controlled Trials from October 25 to November 25, 2020, to identify studies comparing cefazolin with adjunctive macrolides or metronidazole to cefazolin alone. Read More

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Insights into the skin microbiome of sickle cell disease leg ulcers.

Wound Repair Regen 2021 May 8. Epub 2021 May 8.

Department of Dermatology and Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Leg ulcers are estimated to occur in 1%-10% of North American patients with sickle cell disease (SCD). Their pathophysiology remains poorly defined, but as with other chronic wounds, it is hypothesised that the microbial milieu, or microbiome, contributes to their healing and clinical outcomes. This study utilises 16S ribosomal RNA (rRNA) gene sequencing to describe, for the first time, the microbiome of the SCD leg ulcer and its association with clinical factors. Read More

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Predictors of Colorectal Cancer Screening Among African American Men Living with HIV.

J Community Health 2021 May 8. Epub 2021 May 8.

University Pennsylvania Annenberg School of Communication, Philadelphia, USA.

African American men living with HIV are at high risk of colorectal cancer (CRC). Screening to detect CRC is associated with a reduced risk of CRC mortality. However, little is known about CRC screening predictors in this population. Read More

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Does preoperative neoadjuvant chemotherapy impact short-term surgical outcomes in patients with locally advanced colon cancer?

Int J Colorectal Dis 2021 May 8. Epub 2021 May 8.

Department of Surgery, University of Arizona Medical Center, Tucson, AZ, USA.

Background: Preoperative neoadjuvant chemotherapy (NAC) for colon cancer in advanced stages is associated with improved outcomes and tumor regression. The aim of our study was to identify outcomes in patients with colon cancer who received preoperative NAC.

Methods: A 4-year analysis of the American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) was performed. Read More

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The talar body prosthesis treated end-stage ankle arthritis with talar body deficient: a 6-13 years of follow-up outcomes and 6-year survivorship.

Arch Orthop Trauma Surg 2021 May 8. Epub 2021 May 8.

Department of Orthopaedics Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Street, Bangkok noi, Bangkok, Thailand.

Introduction: Talar body deficient provides a unique challenge for ankle arthritis treatment. We studied the clinical-radiographic outcomes at 6 to 13 years and 6 year prosthesis survivorship of patients treated for ankle arthritis with poor talar body bone stock using a talar body prosthesis (TBP).

Materials And Methods: Between 2008 and 2015, we treated 32 consecutive end-stage ankle arthritis patients with talar body deficiency by TBP implantation and fascia interposition. Read More

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The Impact of Intensifying Prostate Cancer Screening in Black Men: A Model-Based Analysis.

J Natl Cancer Inst 2021 May 8. Epub 2021 May 8.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Background: Black men in the United States have markedly higher rates of prostate cancer than the general population. National guidelines for prostate-specific antigen (PSA) screening do not provide clear guidance for this high-risk population. The purpose of this study is to estimate the benefit and harm of intensified PSA screening in Black men. Read More

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Safety and efficacy of autologous whole cell vaccines in hematologic malignancies: A systematic review and meta-analysis.

Hematol Oncol 2021 May 8. Epub 2021 May 8.

Cancer Therapeutics Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Autologous cell vaccines use a patient's tumor cells to stimulate a broad antitumor response in vivo. This approach shows promise for treating hematologic cancers in early phase clinical trials, but overall safety and efficacy remain poorly described. We conducted a systematic review assessing the use of autologous cell vaccination in treating hematologic cancers. Read More

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Persistence of abnormal global longitudinal strain in women with peripartum cardiomyopathy.

Echocardiography 2021 May 8. Epub 2021 May 8.

Department of Cardiovascular Medicine, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine, Lebanon, NH, USA.

Objectives: Data regarding the longitudinal relationship of global longitudinal strain (GLS) and echocardiographic parameters are lacking in peripartum cardiomyopathy (PPCM). We evaluated GLS and its correlation with change (∆) in left ventricular ejection fraction (LVEF).

Methods: We retrospectively identified women age ≥16 years hospitalized at Montefiore Medical Center in Bronx, NY from 1999-2015 with International Statistical Classification of Diseases and Related Health Problems, 9th revision codes for PPCM or an occurrence of unexplained heart failure during or up to 5 months postpartum. Read More

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International registry of dermatological manifestations secondary to COVID-19 infection in 347 Hispanic patients from 25 countries.

Int J Dermatol 2021 May 8. Epub 2021 May 8.

Departamento de Dermatología, Instituto de Biomedicina, Universidad Central de Venezuela, Hospital Vargas Clínica El Ávila, Caracas, Venezuela.

Background: The infection by coronavirus disease 2019 (COVID-19) has been associated with multiple cutaneous manifestations, although characterization of them in Hispanic patients with darker skin phototypes is lacking. The objective of this study is to characterize the clinical dermatological manifestations associated with COVID-19 infection in cases with few or without general symptoms in patients from Latin America.

Methods: Cross-sectional study using a questionnaire that was made for health professionals (physicians with a specialty in dermatology) to investigate dermatological lesions associated with COVID-19 infection in patients from 25 countries of Latin America. Read More

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Bilingualism, assessment language, and the Montreal Cognitive Assessment in Mexican Americans.

J Am Geriatr Soc 2021 May 7. Epub 2021 May 7.

Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA.

Background/objectives: Assessment of cognition in linguistically diverse aging populations is a growing need. Bilingualism may complicate cognitive measurement precision, and bilingualism may vary across Hispanic/Latinx sub-populations. We examined the association among bilingualism, assessment language, and cognitive screening performance in a primarily non-immigrant Mexican American community. Read More

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Neighborhood Poverty and Incident Heart Failure: an Analysis of Electronic Health Records from 2005 to 2018.

J Gen Intern Med 2021 May 7. Epub 2021 May 7.

Department of Preventive Medicine, Northwestern University, Chicago, IL, USA.

Background: Neighborhood-level characteristics, such as poverty, have been associated with risk factors for heart failure (HF), including hypertension and diabetes mellitus. However, the independent association between neighborhood poverty and incident HF remains understudied.

Objective: To evaluate the association between neighborhood poverty and incident HF using a "real-world" clinical cohort. Read More

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African Americans, Caribbean Blacks and Depression: Which Biopsychosocial Factors Should Social Workers Focus On? Results from the National Survey of American Life (NSAL).

Community Ment Health J 2021 May 7. Epub 2021 May 7.

The University at Albany, 1400 Washington Ave, Albany, NY, 12222, USA.

Research suggests that African Americans may be more likely to experience depression, especially severe depression, than other racial or ethnic groups in the United States. Overall there is scant research comparing the relationship between ethnicity and depression among the U.S. Read More

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Assessing Knowledge and Perceptions About Cancer Among American Indians of the Zuni Pueblo, NM.

J Cancer Educ 2021 May 7. Epub 2021 May 7.

Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.

American Indians (AIs) in New Mexico have lower cancer screening rates compared to other populations and are more likely to be diagnosed with cancer at an advanced stage of the disease as reported by Li et al. (Archives of Internal Medicine 163(1):49-56, 2003). AIs also have the lowest 5-year cancer survival rates compared to any ethnic/racial group in the USA as reported by Clegg et al. Read More

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The importance of community and culture for the recruitment, engagement, and retention of Chinese American immigrants in health interventions.

Transl Behav Med 2021 May 8. Epub 2021 May 8.

Department of Population Health, NYU Langone Health, New York, NY, USA.

Chinese Americans experience cancer health disparities throughout the entire cancer continuum. Yet, they remain underrepresented in health research in part due to barriers in recruitment, engagement, and retention. This paper describes the strategies that we devised, by drawing upon our experiences with conducting two culturally sensitive cancer intervention studies, to help researchers improve their recruitment and retention rates of Chinese Americans in health research and address the gap in knowledge on intervention research with this population. Read More

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TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines.

Nat Immunol 2021 May 7. Epub 2021 May 7.

Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.

The innate immune response is critical for recognizing and controlling infections through the release of cytokines and chemokines. However, severe pathology during some infections, including SARS-CoV-2, is driven by hyperactive cytokine release, or a cytokine storm. The innate sensors that activate production of proinflammatory cytokines and chemokines during COVID-19 remain poorly characterized. Read More

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Collagen fiber regulation in human pediatric aortic valve development and disease.

Sci Rep 2021 May 7;11(1):9751. Epub 2021 May 7.

Department of Cell and Molecular Pharmacology, MUSC Proteomics Center, Bruker-MUSC Clinical Glycomics Center of Excellence, Medical University of South Carolina, 173 Ashley Ave, BSB358, Charleston, SC, 29425, USA.

Congenital aortic valve stenosis (CAVS) affects up to 10% of the world population without medical therapies to treat the disease. New molecular targets are continually being sought that can halt CAVS progression. Collagen deregulation is a hallmark of CAVS yet remains mostly undefined. Read More

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Comparison of radiomic feature aggregation methods for patients with multiple tumors.

Sci Rep 2021 May 7;11(1):9758. Epub 2021 May 7.

Department of Therapeutic Radiology, Yale School of Medicine, New Haven, USA.

Radiomic feature analysis has been shown to be effective at analyzing diagnostic images to model cancer outcomes. It has not yet been established how to best combine radiomic features in cancer patients with multifocal tumors. As the number of patients with multifocal metastatic cancer continues to rise, there is a need for improving personalized patient-level prognosis to better inform treatment. Read More

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Maternal pre-pregnancy weight and early life lower respiratory tract infections in a low-income urban minority birth cohort.

Sci Rep 2021 May 7;11(1):9790. Epub 2021 May 7.

Center On the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

The prevalence of maternal obesity has increased dramatically with adverse consequences on infant health. Prior studies have reported associations between maternal obesity and childhood wheeze, asthma as well as lower respiratory tract infections (LRTI). However, studies examining the association of obesity with early-life LRTIs in low-income urban minority populations are still lacking. Read More

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Incremental prognostic value of visually estimated coronary artery calcium in patients undergoing positron emission tomography imaging.

Open Heart 2021 May;8(1)

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Objective: Visually estimated coronary artery calcium (VECAC) from chest CT or attenuation correction (AC)/CT obtained during positron emission tomography (PET)-myocardial perfusion imaging (MPI) is feasible. Our aim was to determine the prognostic value of VECAC beyond conventional risk factors and PET imaging parameters, including coronary flow reserve (CFR).

Methods: We analysed 608 patients without known coronary artery disease who underwent PET-MPI between 2012 and 2016 and had AC/CT and/or chest CT images. Read More

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