6,862 results match your criteria American Journal of Transplantation[Journal]


Consent and labeling in the use of infectious risk donor kidneys: a response to "Information Overload.

Am J Transplant 2018 Jun 19. Epub 2018 Jun 19.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

We thank Singh et al for their interest in our work on the survival benefit conferred by increased infectious risk kidneys (IRD) (1). We agree that our findings of substantial benefit and elevated discard rates of IRD kidneys, coupled with existing literature on their low infectious risk, support broader utilization of these so-labeled kidneys. Physicians and patients considering these offers can also turn to our risk calculator (www. Read More

View Article

Genetic immune and inflammatory markers associated with diabetes in solid organ transplant recipients.

Am J Transplant 2018 Jun 19. Epub 2018 Jun 19.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.

New-onset diabetes after transplantation (NODAT) is a complication following solid organ transplantation (SOT) and may be related to immune or inflammatory responses. We investigated whether single nucleotide polymorphisms (SNPs) within 158 immune- or inflammation-related genes contribute to NODAT in SOT recipients. The association between 263 SNPs and NODAT were investigated in a discovery sample of SOT recipients from the Swiss Transplant Cohort Study (STCS, n =696). Read More

View Article
June 2018
1 Read

Successful Pregnancies after Islet Transplantation for Type 1 Diabetes.

Am J Transplant 2018 Jun 19. Epub 2018 Jun 19.

Surgery, Division of Transplantation, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Pregnancy has rarely been attempted following successful islet transplantation due to concerns over a possible detrimental effect of the increased insulin demands of pregnancy on the islet graft with subsequent post-gestation hyperglycemia (1, 2), and for allogeneic islets, concern over a possible detrimental effect of the required immunosuppression on fetal outcomes (2). Recently published on-line, Assalino et al. report a 29-year-old women with type 1 diabetes who became insulin-independent after receiving two islet infusions, and two-years later successfully carried a pregnancy to term without requiring gestational insulin therapy that resulted in a healthy male child (3). Read More

View Article

Gut Microbiota Dysbiosis and Diarrhea in Kidney Transplant Recipients.

Am J Transplant 2018 Jun 19. Epub 2018 Jun 19.

Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, NY.

Post-transplant diarrhea is associated with kidney allograft failure and death but its etiology remains unknown in the majority of cases. Because altered gut microbial ecology is a potential basis for diarrhea, we investigated whether post-transplant diarrhea is associated with gut dysbiosis. We enrolled 71 kidney allograft recipients for serial fecal specimen collections in the first 3 months of transplantation and profiled the gut microbiota using 16S rRNA gene V4-V5 deep sequencing. Read More

View Article
June 2018
1 Read

Dynamics of virus-specific T cell immunity in pediatric liver transplant recipients.

Am J Transplant 2018 Jun 13. Epub 2018 Jun 13.

Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX.

Immunosuppression following solid organ transplantation (SOT) has a deleterious effect on cellular immunity leading to frequent and prolonged viral infections. To better understand the relationship between post-transplant immunosuppression and circulating virus-specific T cells, we prospectively monitored the frequency and function of T cells directed to a range of latent (CMV, EBV, HHV6, BK) and lytic (AdV) viruses in 16 children undergoing liver transplantation for up to 1 year post-transplant. Following transplant, there was an immediate decline in circulating virus-specific T cells, which recovered post-transplant, coincident with the introduction and subsequent routine tapering of immunosuppression. Read More

View Article

Improved keratinocyte carcinoma outcomes with annual dermatology assessment after solid organ transplantation: Population-based cohort study.

Am J Transplant 2018 Jun 13. Epub 2018 Jun 13.

Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.

Solid organ transplant recipients have a high risk of keratinocyte carcinoma (non-melanoma skin cancer). Consensus-based transplant guidelines recommend annual dermatological examination but the impact on skin cancer-related outcomes is unclear. We conducted a population-based, retrospective, inception cohort study using administrative health databases in Ontario, Canada to evaluate the association between adherence to annual dermatology assessments (time-varying exposure) and keratinocyte carcinoma-related morbidity and mortality after transplantation. Read More

View Article

Allograft and patient survival after sequential HSCT and kidney transplantation from the same donor- a multicenter analysis.

Am J Transplant 2018 Jun 13. Epub 2018 Jun 13.

Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria.

Tolerance induction through simultaneous hematopoietic stem cell- and renal transplantation has shown promising results, but it is hampered by the toxicity of preconditioning therapies and graft-versus-host disease. Moreover, renal function has never been compared to conventionally transplanted patients, thus, whether donor-specific tolerance results in improved outcomes remains unanswered. We collected follow-up data of published cases of renal transplantations after hematopoietic stem cell transplantation from the same donor and compared patient- and transplant kidney survival- as well as function with caliper-matched living-donor renal transplantations from the Austrian dialysis and transplant registry. Read More

View Article
June 2018
2 Reads

Vaccination against cytomegalovirus: Still at base camp?

Authors:
Vincent C Emery

Am J Transplant 2018 Jun 12. Epub 2018 Jun 12.

University of Surrey, Guildford, UK.

View Article

Response to "Shifting the conversation on outcomes reporting".

Am J Transplant 2018 Jun 12. Epub 2018 Jun 12.

Department of Medical Social Sciences, Feinberg School of Medicine, Chicago, IL.

We read with great interest the recent publication of Schold, et al., and the Greenwald's accompanying editorial comments. Schold and colleagues found that the Scientific Registry for Transplant Recipients (SRTR) 5-tier ratings based on graft survival has limited utility for transplant center performance evaluation. Read More

View Article

Very late relapse of hepatitis C virus infection immediately after liver transplantation.

Am J Transplant 2018 Jun 7. Epub 2018 Jun 7.

Université Claude-Bernard Lyon 1, Domaine Rockefeller, Lyon, France.

Late relapse of hepatitis C virus infection is very rare in the era of modern direct acting antiviral therapy. We report here the first case of a late relapse, after direct acting antiviral therapy, occurring immediately after liver transplantation (LT), with 93 weeks of sustained virological response before LT. HCV-RNA in serum and in liver biopsy was negative the day of LT and relapse was diagnosed eleven days after LT. Read More

View Article
June 2018
1 Read

Tolerance Induction in Kidney Transplantation.

Authors:
Lara C Pullen

Am J Transplant 2018 Jun;18(6):1297-1298

View Article

A Cause for Leaky Guts.

Am J Transplant 2018 Jun;18(6):1299

View Article

Overdose deaths involving opioids, cocaine, and psychostimulants - United States, 2015-2016.

Am J Transplant 2018 Jun;18(6):1556-1568

Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, CDC, Atlanta, GA, USA.

View Article

Corrigendum.

Authors:

Am J Transplant 2018 Jun 6;18(6):1579. Epub 2018 Apr 6.

View Article

Erratum.

Authors:

Am J Transplant 2018 Jun 30;18(6):1580. Epub 2018 Apr 30.

View Article

And equal access for all? The future of deceased donor kidney allocation.

Am J Transplant 2018 Jun 7. Epub 2018 Jun 7.

Director of Transplant Medicine, Yale University School of Medicine, Boardman 124, 330 Cedar Street, New Haven, Connecticut, 06520.

End stage renal disease (ESRD) and it co-morbidities do not affect patients differently based upon where they live. However access, referring to both referral for evaluation for kidney transplantation and equitable allocation of organs to those on the list, is very different depending on place of residence.(1) This is a complicated problem with many facets including regional differences in the prevalence of kidney disease, access to healthcare, availability of suitable deceased donor organs and the organ acceptance practices of transplant centers. Read More

View Article

Excluding patients from transplant due to social support: Results from a national survey of transplant providers.

Am J Transplant 2018 Jun 7. Epub 2018 Jun 7.

VA Saint Louis Health Care System, Surgery, St. Louis, MO.

Social support is used to determine transplant eligibility despite lack of an evidence-base and vague regulatory guidance. It is unknown how many patients are disqualified from transplantation due to inadequate support, and whether providers feel confident using these subjective criteria to determine eligibility. Transplant providers (n=551) from 202 centers estimated that, on average, 9. Read More

View Article

The future of marginal kidney repair in the context of normothermic machine perfusion.

Am J Transplant 2018 Jun 7. Epub 2018 Jun 7.

Department of Surgery, University of Cambridge, Cambridge, UK, CB2 0QQ.

Normothermic machine perfusion (NMP) is a technique that utilizes extra-corporeal membrane oxygenation to recondition and repair kidneys at near body temperature prior to transplantation. The application of this new technology has been fuelled by a significant increase in the use of the kidneys donated after circulatory death (DCD), which are more susceptible to ischaemic injury. Preliminary results indicate that normothermic machine perfusion itself may be able to repair marginal organs prior to transplantation. Read More

View Article

If hepatitis C therapy is so great, why isn't everyone doing it?

Authors:
Robert S Brown

Am J Transplant 2018 Jun 4. Epub 2018 Jun 4.

Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY, USA.

View Article

Improved Outcomes of Islet Autotransplantation after Total Pancreatectomy by Combined Blockade of IL-1β and TNFα.

Am J Transplant 2018 Jun 4. Epub 2018 Jun 4.

Islet Cell Laboratory, Baylor Research Institute, Dallas, TX.

The efficacy of islet transplantation is compromised by a significant loss of islet mass posttransplant due to an innate inflammatory reaction. Here we report the use of a combination of etanercept and anakinra to block inflammatory islet damage in 100 patients undergoing total pancreatectomy with islet autotransplantation. The patients were divided into three groups: no treatment (CTL), etanercept alone (ETA), or a combination of etanercept and anakinra (ANA+ETA). Read More

View Article

Another piece of the antibody puzzle: Observations from the HALT study.

Am J Transplant 2018 Jun 4. Epub 2018 Jun 4.

University Health Network, University of Toronto, Toronto, Canada.

View Article

Innervation of an engineered muscle graft for reconstruction of muscle defects.

Am J Transplant 2018 Jun 1. Epub 2018 Jun 1.

Department of Biomedical Engineering, Technion - Israel Institute of Technology, Haifa, Israel.

Autologous muscle flaps are commonly used to reconstruct defects that involve muscle impairment. In order to maintain viability and functionality of these flaps, they must be properly vascularized and innervated. Tissue engineered muscles could potentially replace autologous muscle tissue, but still require establishment of sufficient innervation to ensure functionality. Read More

View Article

It is time for board certification in transplant pharmacotherapy.

Am J Transplant 2018 Jun 1. Epub 2018 Jun 1.

Department of Surgery, Medical University of South Carolina, Charleston, SC, USA.

View Article

Identification of risk epitope mismatches associated with de novo donor-specific HLA antibody development in cardiothoracic transplantation.

Am J Transplant 2018 May 30. Epub 2018 May 30.

HLA Laboratory, Laboratory Medicine Program, University Health Network, Toronto, Canada.

The development of de novo donor-specific HLA antibodies (dnDSA) after transplantation is associated with graft failure, mortality, and cost. There is no effective therapeutic intervention to prevent dnDSA or ameliorate associated injury. The aims of this study were to identify specific HLA factors associated with dnDSA development and to propose primary prevention strategies that could reduce the incidence of dnDSA without prohibitively limiting access to transplant. Read More

View Article

Center effect on posttransplant survival among currently active United States pediatric heart transplant centers.

Am J Transplant 2018 May 28. Epub 2018 May 28.

Department of Cardiology, Boston Children's Hospital, Boston, MA, USA.

The official analysis of posttransplant survival considers only recently transplanted patients and suggests absence of outcome differences among pediatric heart transplant (HT) centers. We sought to compare posttransplant survival among currently active pediatric HT centers in the United States over 15 years of activity. We identified all children <18 years old who underwent their first HT during 2000-2014 at US centers active during 2013-14. Read More

View Article
May 2018
2 Reads

De novo or early conversion to everolimus and long-term cancer outcomes in kidney transplant recipients: A trial-based linkage study.

Am J Transplant 2018 May 26. Epub 2018 May 26.

Renal Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Choice of immunosuppression may modify the risk of cancer after kidney transplantation, however long-term data are lacking. Using the Australian and New Zealand Dialysis and Transplant Registry, we compared the nine-year risk of incident cancer, non-melanoma skin cancer (NMSC) and death attributed to cancer among participants, from Australia and New Zealand, in four randomised-controlled trials which compared de novo or early switch to an everolimus-containing regimen with calcineurin-inhibitor-based triple therapy. An adjusted Cox-model with random-effects was used to determine such risks. Read More

View Article

Financial burden associated with time to return to work after living kidney donation.

Am J Transplant 2018 May 25. Epub 2018 May 25.

Department of Surgery, University of Minnesota, Minneapolis, MN, USA.

Many living kidney donors undertake a significant financial burden in order to donate. We studied the association between time to return to work and reported financial burden. Kidney donors who donated from 2/2005 through 12/2015 (n = 1012) were surveyed 6 months after donation and asked about occupation, time to return to work, and financial burden (on a 10-point Likert scale). Read More

View Article

Transplantation of pediatric renal allografts from donors less than 10 kg.

Am J Transplant 2018 May 24. Epub 2018 May 24.

Schulich School of Medicine, Dentistry, Western University, London, ON, Canada.

Few transplant programs use kidneys from donors with body weight (BW) <10 kg. We hypothesized that pediatric en bloc transplants from donors with BW <10 kg, would provide similar transplant outcomes to larger grafts. All pediatric en bloc renal transplants performed at our center between 2001 and 2017 were reviewed (N=28). Read More

View Article
May 2018
2 Reads

Cost-effectiveness of using kidneys from hepatitis C nucleic acid test-positive donors for transplantation in hepatitis C-negative recipients.

Am J Transplant 2018 May 23. Epub 2018 May 23.

Division of Nephrology, University of British Columbia, Vancouver, Canada.

Kidneys from deceased donors who are hepatitis C virus (HCV) nucleic acid test positive are infrequently used for transplantation in HCV-negative patients due to concerns about disease transmission. With the development of direct-acting antivirals (DAAs) for HCV, there is now potential to use these kidneys in HCV-negative candidates. However, the high cost of DAAs poses a challenge to adoption of this strategy. Read More

View Article
May 2018
1 Read

Rethinking performance benchmarks in kidney transplantation.

Am J Transplant 2018 May 23. Epub 2018 May 23.

Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

View Article

Implementing an innovated preservation technology: The American Society of Transplant Surgeons' (ASTS) Standards Committee White Paper on Ex Situ Liver Machine Perfusion.

Am J Transplant 2018 May 23. Epub 2018 May 23.

Lahey Hospital and Medical Center, Burlington, MA, USA.

The pervasive shortage of deceased donor liver allografts contributes to significant waitlist mortality despite efforts to increase organ donation. Ex vivo liver perfusion appears to enhance preservation of donor organs, extending viability and potentially evaluating function in organs previously considered too high risk for transplant. These devices pose novel challenges for organ allocation, safety, training, and finances. Read More

View Article

Failure of voriconazole therapy due to acquired azole resistance in Aspergillus fumigatus in a kidney transplant recipient with chronic necrotizing aspergillosis.

Am J Transplant 2018 May 22. Epub 2018 May 22.

Infectious Diseases Department, Necker Hospital, Assistance Publique-Hôpitaux de Paris, University Paris Descartes, Paris, France.

Invasive aspergillosis (IA) affects lungs and disseminates mostly in patients with neutropenia and/or receiving immunosuppressive and steroid therapies. Despite progress in diagnosis and therapy of IA, it is still characterized by a high mortality rate. Currently, voriconazole is considered as the standard therapy for invasive aspergillosis. Read More

View Article

Tacrolimus prevents von Willebrand factor secretion by allostimulated human glomerular endothelium.

Am J Transplant 2018 May 22. Epub 2018 May 22.

Transplantation Unit, Renal Division, Department of Medicine, University Health Center of Quebec, Faculty of Medicine, Laval University, Québec, QC, Canada.

Little is known about the endothelial injury caused directly by circulating donor-specific antibodies (DSAs) during antibody-mediated rejection. von Willebrand factor (vWF) is a highly thrombotic glycoprotein stored in Weibel-Palade bodies in endothelial cells. It has been shown that its secretion is triggered by allostimulation. Read More

View Article

Vascular reconstruction technique of a perforated portal vein during a pediatric total pancreatectomy and islet autotransplant.

Am J Transplant 2018 May 22. Epub 2018 May 22.

Division of Transplantation, Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.

Hereditary pancreatitis (HP) is a progressive disease that can manifest in childhood with debilitating, relapsing pain. A total pancreatectomy and islet autotransplant (TPIAT) is a surgical option to relieve chronic pain while preserving the available β-cell mass. The clinical course of HP is fraught with pancreatitis-related sequelae that can both necessitate and complicate a TPIAT. Read More

View Article
May 2018
1 Read

Polymer scaffolds for pancreatic islet transplantation - Progress and challenges.

Am J Transplant 2018 May 22. Epub 2018 May 22.

Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Pancreatic-islet transplantation is a safe and noninvasive therapy for type 1 diabetes. However, the currently applied site for transplantation, ie, the liver, is not the optimal site for islet survival. Because the human body has shortcomings in providing an optimal site, artificial transplantation sites have been proposed. Read More

View Article

Urinary metabolites predict prolonged duration of delayed graft function in DCD kidney transplant recipients.

Am J Transplant 2018 May 22. Epub 2018 May 22.

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

Extending kidney donor criteria, including donation after circulatory death (DCD), has resulted in increased rates of delayed graft function (DGF) and primary nonfunction. Here, we used Nuclear Magnetic Resonance (NMR) spectroscopy to analyze the urinary metabolome of DCD transplant recipients at multiple time points (days 10, 42, 180, and 360 after transplantation). The aim was to identify markers that predict prolonged duration of functional DGF (fDGF). Read More

View Article

The effect of Share 35 on biliary complications: An interrupted time series analysis.

Am J Transplant 2018 May 16. Epub 2018 May 16.

Department of Surgery, Medical University of South Carolina, Charleston, SC, USA.

The purpose of the Share 35 allocation policy was to improve liver transplant waitlist mortality, targeting high MELD waitlisted patients. However, policy changes may also have unintended consequences that must be balanced with the primary desired outcome. We performed an interrupted time series assessing the impact of Share 35 on biliary complications in a select national liver transplant population using the Vizient CDB/RM database. Read More

View Article
May 2018
1 Read

Ureterocalicostomy with lower pole nephrectomy in a renal transplant: A case report.

Am J Transplant 2018 May 16. Epub 2018 May 16.

Department of Urology, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.

As the number of kidney transplants continues to rise, so does the number and complexities of surgical-related complications, which may be associated with increased morbidity and potentially graft loss. Ureteral stenosis, the most prevalent urological complication, may require diverse techniques for surgical correction depending on several recipient and graft abnormalities. Here we report the surgical and clinical outcomes of a 62-year-old man with a posttransplant pyeloureterostomy stricture successfully treated with ureterocalicostomy after a lower pole nephrectomy. Read More

View Article
May 2018
1 Read

Comparison of de novo IgM and IgG anti-HLA DSAs between belatacept- and calcineurin-treated patients: An analysis of the BENEFIT and BENEFIT-EXT trial cohorts.

Am J Transplant 2018 May 16. Epub 2018 May 16.

Emory University School of Medicine, Pathology& Laboratory Medicine, Atlanta, GA, USA.

Preventing conversion of donor-specific anti-HLA antibodies (DSAs) from an IgM-to-IgG could a way to prevent chronic rejection. We evaluated whether belatacept-treated patients (belatacept less-intensive [LI] or more-intensive [MI] regimens) have a lower rate of conversion than do cyclosporine A (CsA)-treated patients. We included 330 HLA-mismatched patients from 2 phase 3 trials with either (a) complete donor/recipient HLA-A, -B, -DR, and -DQ loci typing or (b) incomplete HLA typing with IgG DSAs detected pretransplant or posttransplant. Read More

View Article

Tailoring the homing capacity of human Tregs for directed migration to sites of Th1-inflammation or intestinal regions.

Am J Transplant 2018 May 15. Epub 2018 May 15.

Department of Surgery, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.

Cell-based therapy with CD4 FOXP3 regulatory T cells (Tregs) is a promising strategy to limit organ rejection and graft-vs-host disease. Ongoing clinical applications have yet to consider how human Tregs could be modified to direct their migration to specific inflammation sites and/or tissues for more targeted immunosuppression. We show here that stable, homing-receptor-tailored human Tregs can be generated from thymic Tregs isolated from pediatric thymus or adult blood. Read More

View Article
May 2018
4 Reads

Subclinical inflammation phenotypes and long-term outcomes after pediatric kidney transplantation.

Am J Transplant 2018 May 15. Epub 2018 May 15.

Department of Medicine, University of Alabama School of Medicine, Birmingham, AL, USA.

The implementation of surveillance biopsies in pediatric kidney transplantation remains controversial. Surveillance biopsies detect subclinical injury prior to clinical dysfunction, which could allow for early interventions that prolong allograft survival. We conducted a single-center retrospective cohort study of 120 consecutive pediatric kidney recipients, of whom 103 had surveillance biopsies ≤ 6 months post-transplant. Read More

View Article

Response to "It is time to revise the kidney allocation system to restore the pediatric advantage".

Am J Transplant 2018 May 15. Epub 2018 May 15.

University of Alabama at Birmingham Comprehensive Transplant Institute, Birmingham, AL, USA.

View Article

Pediatric heart transplantation at adult-specialty centers in the United States: A multicenter registry analysis.

Am J Transplant 2018 May 14. Epub 2018 May 14.

Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Recent Organ Procurement and Transplantation Network bylaw revisions mandate that US transplant programs have an "approved pediatric component" in order to perform heart transplantation (HT) in patients <18 years old. The impact of this change on adolescents, a group known to be at high risk for graft loss and nonadherence, is unknown. We studied all US primary pediatric (age <18 years) HT from 2000 to 2015 to compare graft survival between centers organized mainly for adult versus pediatric care. Read More

View Article

Twenty-four-hour normothermic perfusion of discarded human kidneys with urine recirculation.

Am J Transplant 2018 May 14. Epub 2018 May 14.

Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.

Transportable normothermic kidney perfusion for 24 hours or longer could enable viability assessment of marginal grafts, increased organ use, and improved transplant logistics. Eleven clinically declined kidneys were perfused normothermically, with 6 being from donors after brain death (median cold ischemia time 33 ± 36.9 hours) and 5 being from donors after circulatory death (36. Read More

View Article

Clinical outcomes of hepatitis C treatment before and after kidney transplantation and its impact on time to transplant: A multicenter study.

Am J Transplant 2018 May 14. Epub 2018 May 14.

Transplant Center, Mayo Clinic, Phoenix, AZ, USA.

Waitlist time for kidney transplantation is long but may be shortened with the utilization of hepatitis C positive allografts. We retrospectively reviewed the course of 36 hepatitis C positive patients awaiting kidney transplantation at 2 large centers within the same health system, with near-identical care delivery models with the exception of timing of hepatitis C treatment, to determine the impact of timing of hepatitis C treatment on access to transplant, waitlist time, and treatment efficacy and tolerability. The majority of patients had hepatitis C genotype 1a or 1b, and all received direct acting antiviral therapy with 100% treatment response. Read More

View Article
May 2018
2 Reads

Innovation in organ transplantation: A meeting report.

Am J Transplant 2018 May 9. Epub 2018 May 9.

Uniformed Services University School of Medicine, Silver Spring, MD, USA.

This workshop targeted opportunities to stimulate transformative innovation in organ transplantation. Participants reached consensus regarding the following: (1) Mechanisms are needed to improve the coordination of policy and oversight activities, given overlapping responsibilities for transplantation and clinical investigation among federal agencies. Innovative clinical trials span traditional administrative boundaries and include stakeholders with diverse interests. Read More

View Article

Intellectual and academic outcomes after pediatric liver transplantation: Relationship with transplant-related factors.

Am J Transplant 2018 May 9. Epub 2018 May 9.

Department of Gastroenterology, The Children's Hospital at Westmead, Sydney, Australia.

As survival rates for pediatric liver transplant continue to increase, research attention is turning toward long-term functional consequences, with particular interest in whether medical and transplant-related factors are implicated in neurocognitive outcomes. The relative importance of different factors is unclear, due to a lack of methodological uniformity, inclusion of differing primary diagnoses, varying transplant policies, and organ availability in different jurisdictions. This cross-sectional, single-site study sought to address various methodological limitations in the literature and the paucity of studies conducted outside of North America and Western Europe by examining the intellectual and academic outcomes of Australian pediatric liver transplant recipients (N = 40). Read More

View Article

Posttransplant muscle mass measured by urinary creatinine excretion rate predicts long-term outcomes after liver transplantation.

Am J Transplant 2018 May 9. Epub 2018 May 9.

Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Long-term survival in orthotopic liver transplant (OLT) recipients remains impaired because of many contributing factors, including a low pretransplant muscle mass (or sarcopenia). However, influence of posttransplant muscle mass on survival is currently unknown. We hypothesized that posttransplant urinary creatinine excretion rate (CER), an established noninvasive marker of total body muscle mass, is associated with long-term survival after OLT. Read More

View Article

A randomized, phase 2 study of ASP0113, a DNA-based vaccine, for the prevention of CMV in CMV-seronegative kidney transplant recipients receiving a kidney from a CMV-seropositive donor.

Am J Transplant 2018 May 9. Epub 2018 May 9.

Immunology, Transplant, Inflammation & CNS/Pain, Astellas Pharma Global Development, Inc., Northbrook, IL, USA.

Cytomegalovirus (CMV) is a latent infection in most infected individuals, but can be pathogenic in immunocompromised kidney transplant recipients. ASP0113 is a DNA-based vaccine for the prevention of CMV-related mortality and end-organ disease in transplant recipients. The efficacy, safety, and immunogenicity of ASP0113 was assessed in a phase 2, double-blind, placebo-controlled study in CMV-seronegative kidney transplant recipients receiving a kidney from a CMV-seropositive donor. Read More

View Article