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    6711 results match your criteria American Journal of Transplantation[Journal]

    1 OF 135

    BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model.
    Am J Transplant 2018 Feb 21. Epub 2018 Feb 21.
    Clinical Islet Transplant Program, Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
    Islet transplantation has become a well-established therapy for select patients suffering from type 1 diabetes. Viability and engraftment can be compromised by the generation of oxidative stress encountered during isolation and culture. We evaluate whether administration of BMX-001, and its earlier derivative, BMX-010 could improve islet function and engraftment outcomes. Read More

    Serelaxin Induces Notch1 Signaling and Alleviates Hepatocellular Damage in Orthotopic Liver Transplantation.
    Am J Transplant 2018 Feb 21. Epub 2018 Feb 21.
    The Dumont-UCLA Transplant Center, Department of Surgery, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at, University of California, Los Angeles, CA, 90095.
    Liver ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). We have reported on the crucial role of macrophage Notch1 signaling in mouse warm hepatic IRI model. However, its clinical relevance or therapeutic potential remain unknown. Read More

    Isolated vascular "v" lesions in liver allografts: How to approach this unusual finding.
    Am J Transplant 2018 Feb 21. Epub 2018 Feb 21.
    Department of Pathology, Division of Liver and Transplantation Pathology, University of Pittsburgh, Medical Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
    According to the Banff criteria for kidney allografts, isolated vascular or "v" lesions are defined as intimal inflammation, age-inappropriate fibro-intimal hyperplasia, or both, without the presence of associated interstitial T cell-mediated rejection (TCMR). In general, these lesions portend a worse outcome for kidney allografts, particularly in those where the "v" lesions are identified in patients with co-existent donor specific antibodies (DSA) or later after transplantation. Although affected arteries are rarely sampled in liver allograft biopsies, we identified 9 patients at a mean of 1,805 days post-transplantation and compared these to matched controls. Read More

    Differential effects of donor-specific HLA antibodies in living- versus deceased-donor transplantation.
    Am J Transplant 2018 Feb 21. Epub 2018 Feb 21.
    Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
    The presence of donor-specific anti-HLA antibodies (DSA) is associated with increased risk of graft failure after kidney transplantation. We hypothesized that DSA against HLA class-I, -II or both indicate a different risk for graft loss between deceased- and living-donor transplantation. In this study we investigated the impact of pretransplant DSA, assessed using single antigen bead assays, on long-term graft survival in 3237 deceased- and 1487 living-donor kidney transplantations with a negative complement-dependent crossmatch. Read More

    Dietary Approach to Stop Hypertension (DASH) diet and risk of renal function decline and all-cause mortality in renal transplant recipients.
    Am J Transplant 2018 Feb 21. Epub 2018 Feb 21.
    Departments of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
    Renal transplant recipients (RTR) are at risk of decline of graft function and premature mortality, with high blood pressure as important risk factor for both. To study the association of the Dietary Approach to Stop Hypertension (DASH) diet with these adverse events, we conducted a prospective cohort study of adult RTR. Dietary data was collected using a validated 177-item food frequency questionnaire and an overall DASH-score was obtained. Read More

    Are we underestimating the quality of aviremic Hepatitis C positive kidneys? Time to reconsider.
    Am J Transplant 2018 Feb 16. Epub 2018 Feb 16.
    Division of Transplant Surgery, Department of Surgery, University of Washington Medical Center, Seattle, Washington, United States.
    KDRI introduced in 2009 included Hepatitis C serologic but not viremic status of the donors. With NAT testing now being mandatory, further evaluation of these donors is possible. We conducted a retrospective matched case-control analysis of adult deceased donor kidney transplants performed between 12/5/2014 to 12/31/2016 with the KDRI score and HCV Ab and NAT testing status obtained from UNOS database. Read More

    An economic assessment of contemporary kidney transplant practice.
    Am J Transplant 2018 Feb 16. Epub 2018 Feb 16.
    Center for Abdominal Transplantation, Saint Louis University School of Medicine, St. Louis, MO.
    Kidney transplant is the optimal therapy for end stage renal disease, prolonging survival and reducing healthcare spending. Prior economic analyses of kidney transplant using Markov models, have generally assumed compatible, low risk, donors. The economic implications of using deceased donor kidneys with high kidney donor profile index (KPDI) scores, ABO incompatible or HLA incompatible living donors has not been assessed. Read More

    Transplant Recipients are Vulnerable Under the Medicare Part D Benefit.
    Am J Transplant 2018 Feb 15. Epub 2018 Feb 15.
    Transplant and Hepatobiliary Surgery, Lahey Clinic, Burlington, MA.
    Transplant immunosuppressants are often used off-label due to insufficient randomized prospective trial data to achieve organ-specific US Food and Drug Administration (FDA) approval. Transplant recipients who rely on Medicare Part D for immunosuppressant drug coverage are vulnerable to coverage denial for off-label prescriptions, unless use is supported by Centers for Medicare & Medicaid Services (CMS)-approved compendia. An integrated data set including national transplant registry data and 3 years of dispensed pharmacy records was used to identify the prevalence of immunosuppression use that is both off-label and not supported by CMS-approved compendia. Read More

    A Novel Technique for En Bloc Kidney Transplantation from Infant Donors with Extremely Low Body Weight by using the Distal Abdominal Aorta as an Outflow Tract.
    Am J Transplant 2018 Feb 15. Epub 2018 Feb 15.
    Department of Urological Organ Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, 410011, P. R. China.
    Pediatric kidney donors remain underutilized due to the high risk of postoperative thrombosis. To address this problem, we developed a novel en bloc kidney transplantation technique using donor thoracic aorta and the distal abdominal aorta as inflow and outflow tracts, respectively. Briefly, 8 kidneys from deceased infant donors under 5 months old and with low body weight (1. Read More

    Reproductive Health in Women Following Abdominal Organ Transplant.
    Am J Transplant 2018 Feb 15. Epub 2018 Feb 15.
    Transplant Pregnancy Registry (TPR) International, Gift of Life Institute, Philadelphia, PA.
    Fertility is commonly impaired in women with end-stage kidney and liver disease although most women will have restoration of fertility within one year of transplant. Family planning is therefore critical to discuss with reproductive-aged transplant recipients in the early post-transplant period, in order to ensure timely initiation of contraception, and optimal timing for conception. For women seeking pregnancy the risks to the mother, graft, and baby should be discussed, including evaluation of immunosuppression safety and potential for adjusting medications prior to conception. Read More

    Towards Donor Lung Recovery - Gene Expression Changes During Ex Vivo Lung Perfusion of Human Lungs.
    Am J Transplant 2018 Feb 15. Epub 2018 Feb 15.
    Toronto Lung Transplant Program, University of Toronto, Toronto, ON.
    We and others have demonstrated that acellular normothermic ex vivo lung perfusion of high-risk donor lungs can result in post-transplant outcomes equivalent to that of contemporaneous lung transplantation using standard donor lungs. However, the mechanism of this effect remains unclear. Given the restoration of cellular metabolic activity during normothermic perfusion, one possibility is that of lung healing via natural innate recovery mechanisms. Read More

    Impact of Ureteral Stricture and Treatment Choice on Long Term Graft Survival in Kidney Transplantation.
    Am J Transplant 2018 Feb 15. Epub 2018 Feb 15.
    Division of Transplantation, Department of Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI.
    We aimed to evaluate the influence of urological complications occurring within the first year after kidney transplantation on long-term patient and graft outcomes, and sought to examine the impact of the management approach of ureteral strictures on long-term graft function. We collected data on urological complications occurring within the first-year post-transplant. Graft survivals, patient survival, and rejection rates were compared between recipients with and without urological complications. Read More

    Effect of the iChoose Kidney Decision Aid in Improving Knowledge about Treatment Options among Transplant Candidates: a Randomized Controlled Trial.
    Am J Transplant 2018 Feb 15. Epub 2018 Feb 15.
    Department of Surgery, Division of Transplantation, Emory University School of Medicine, 101 Woodruff Circle, 5101 WMB, Atlanta, GA, 30322.
    We previously developed a mobile- and web-based decision aid (iChoose Kidney) that displays individualized risk estimates of survival and mortality, for the treatment modalities of dialysis versus kidney transplantation. We examined the effect of iChoose Kidney on change in transplant knowledge and access to transplant in a randomized controlled trial among patients presenting for evaluation in three transplant centers. A total of 470 patients were randomized to standard transplantation education (control) or standard education plus iChoose Kidney (intervention). Read More

    Study Rationale, Design and Pre-Transplant Alloantibody Status: A First Report of Clinical Trials in Organ Transplantation in Children-04 (CTOTC-04) in Pediatric Heart Transplantation.
    Am J Transplant 2018 Feb 15. Epub 2018 Feb 15.
    Division of Pediatric Cardiology, Monroe Carrell Jr. Children's Hospital at Vanderbilt, Nashville, TN.
    Anti-HLA donor-specific antibodies are associated with worse outcomes following organ transplantation. Among sensitized pediatric heart candidates, requirement for negative donor-specific cytotoxicity crossmatch increases wait times and mortality. However, transplantation with positive crossmatch may increase post-transplant morbidity and mortality. Read More

    VEGF mitigates histone induced pyroptosis in the remote liver injury associated with renal allograft ischemia-reperfusion injury in rats.
    Am J Transplant 2018 Feb 15. Epub 2018 Feb 15.
    Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK.
    Clinical evidence indicated a possible link between renal injury and remote liver injury. Herein, we investigated whether extracellular histone mediates remote hepatic damage following renal graft ischemia-reperfusion injury, whilst vascular endothelial growth factor (VEGF) is protective against remote hepatic injury. In vitro, hepatocyte HepG2 cultures were treated with histone. Read More

    Response to Tumin's letter on Community social deprivation and solid organ transplant outcomes.
    Am J Transplant 2018 Feb 14. Epub 2018 Feb 14.
    Cardiff Transplant Unit, Department of Nephrology, Transplant Surgery University Hospital of Wales Heath Park, Cardiff CF14 4XW United Kingdom of Great Britain, Northern Ireland.
    We read with interest the letter of Tumin et al.referring to our paper on the association between socioeconomic deprivation and survival after pancreas transplantation in England. Tumin et al. Read More

    Incidence, Characterization and Impact of Newly Detected Donor Specific Anti-HLA Antibody in the First Year after Pediatric Heart Transplantation: A Report From the CTOTC-04 Study.
    Am J Transplant 2018 Feb 14. Epub 2018 Feb 14.
    Department of Pathology, UPMC, Pittsburgh, PA.
    Data on the clinical importance of newly detected donor specific antibodies (ndDSA) following pediatric heart transplantation is lacking despite mounting evidence of the detrimental effect of de novo DSA in solid organ transplantation. We prospectively tested 237 pediatric heart transplant recipients for ndDSA in the first year post-transplant in order to determine their incidence, pattern and clinical impact. One third of patients developed ndDSA; when present, these were mostly detected within the first 6 weeks after transplant suggesting that memory responses may predominate over true de novo DSA production in this population. Read More

    A Liver for a kidney: Ethics of trans-organ paired exchange.
    Am J Transplant 2018 Feb 14. Epub 2018 Feb 14.
    Columbia University Medical Center, Department of Surgery, New York, NY.
    Living donation provides important access to organ transplantation, which is the optimal therapy for patients with end-stage liver or kidney failure. Paired exchanges have facilitated thousands of kidney transplants and enable transplantation when the donor and recipient are incompatible. However, frequently willing and otherwise healthy donors have contraindications to donation of the organ that their recipient needs. Read More

    Kidney Exchange Match Rates in a Large Multicenter Clearinghouse.
    Am J Transplant 2018 Feb 13. Epub 2018 Feb 13.
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Kidney paired donation (KPD) can facilitate living donor transplantation for candidates with an incompatible donor, but requires waiting for a match while suffering the morbidity of dialysis. The balance between waiting for KPD versus desensitization or deceased donor transplantation relies on the ability to estimate KPD wait times. We studied donor/candidate pairs in the National Kidney Registry (NKR), a large multi-center KPD clearinghouse, between 10/2011-9/2015 using a competing risk framework. Read More

    Response to: Regarding "HIV protease inhibitors and mortality following kidney transplantation".
    Am J Transplant 2018 Feb 8. Epub 2018 Feb 8.
    University of Alabama at Birmingham Comprehensive Transplant Institute.
    We thank Dr. Sullivan for his thoughtful commentary on our recent analysis of protease inhibitors (PI) and kidney transplant outcomes among HIV-infected kidney transplant recipients.(1, 2) He suggests that post-transplant PI use may be a marker of more advanced HIV infection, driven by genotypic evidence of HIV resistance to multiple classes of antiretroviral therapies. Read More

    Observations on the ex situ perfusion of livers for transplantation.
    Am J Transplant 2018 Feb 8. Epub 2018 Feb 8.
    University of Cambridge, Department of Surgery, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
    Normothermic ex situ liver perfusion might allow viability assessment of livers before transplantation. Perfusion characteristics were studied in 47 liver perfusions, of which 22 resulted in transplants. Hepatocellular damage was reflected in the perfusate transaminase concentrations, which correlated with post-transplant peak transaminase levels. Read More

    The Pursuit of Happiness. The thin line between rights and duties.
    Am J Transplant 2018 Feb 8. Epub 2018 Feb 8.
    Hepatobiliary Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
    We read with some concern the paper by Halazun et al. on the use of elderly liver grafts in US (1). Even if more and more evidence is being accumulated about the favorable outcomes of liver transplantation from very old donors, (2) barriers to a wider use still exist and include both OPOs rules and skepticism from physicians. Read More

    Program-Specific Transplant Rate Ratios: Association with Allocation Priority at Listing and Posttransplant Outcomes.
    Am J Transplant 2018 Feb 3. Epub 2018 Feb 3.
    Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, Minnesota.
    SRTR is considering more prominent reporting of program-specific adjusted transplant rate ratios (TRRs). To enable more useful reporting of TRRs, SRTR updated the transplant rate models to explicitly adjust for components of allocation priority. We evaluated potential associations between TRRs and components of allocation priority that could indicate programs' ability to manipulate TRRs by denying or delaying access to low-priority candidates. Read More

    Antibody-mediated rejection in pediatric small bowel transplantation: Capillaritis is a major determinant of C4d positivity in intestinal transplant biopsies.
    Am J Transplant 2018 Feb 3. Epub 2018 Feb 3.
    Pathology Department, Hôpital Necker, Assistance Publique-Hôpitaux de Paris, Paris, France.
    The diagnostic criteria for antibody-mediated rejection (ABMR) after small bowel transplantation (SBT) are not clearly defined, although the presence of Donor Specific Antibodies (DSA) has been reported to be deleterious for graft survival. We aimed to determine the incidence and prognostic value of DSA and C4d in pediatric SBT and to identify the histopathological features associated with C4d positivity. We studied all intestinal biopsies (IBx) obtained in the first year post-transplantation (n=345) in a prospective cohort of 23 children. Read More

    Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study.
    Am J Transplant 2018 Feb 1. Epub 2018 Feb 1.
    King's College London, MRC Centre for Transplantation, London, UK.
    Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. Read More

    Risk of ESRD in Prior Living Kidney Donors.
    Am J Transplant 2018 Feb 2. Epub 2018 Feb 2.
    Research Department, United Network for Organ Sharing, Richmond, VA.
    We studied End Stage Renal Disease (ESRD) in living kidney donors (LKDs) who donated in the US between 1994 and 2016 (n=123,526), using Organ Procurement and Transplantation Network and Centers for Medicare and Medicaid Services data. 218 LKDs developed ESRD, with a median of 11.1 years between donation and ESRD. Read More

    Recurrence of Eosinophilic Granulomatosis with Polyangitis after Orthotopic Heart Transplant.
    Am J Transplant 2018 Feb 2. Epub 2018 Feb 2.
    Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Eosinophilic granulomatosis with polyangitis (EGPA), previously referred to as Churg-Strauss syndrome, is a necrotizing small vessel vasculitis associated with eosinophilic infiltrates and extravascular granulomas. We report a case of a Caucasian woman successfully bridged to heart transplantation with a continuous flow left ventricular assist device (LVAD) who survived recurrence of EGPA in the allograft. This article is protected by copyright. Read More

    Physical Frailty after Liver Transplantation.
    Am J Transplant 2018 Jan 30. Epub 2018 Jan 30.
    Department of Surgery, University of California-San Francisco, San Francisco, CA.
    Frailty is prevalent in liver transplant candidates, but little is known of what happens to frailty after liver transplantation. We analyzed data for 214 adult liver transplant recipients who had ≥1 frailty assessment using the Liver Frailty Index (LFI) at 3-(n=178), 6-(n=139), or 12-(n=107) months post-transplant [higher values=more frail]. "Frail" and "robust" were defined as LFI ≥4. Read More

    DCD Donor Hemodynamics as Predictor of Outcome After Kidney Transplantation.
    Am J Transplant 2018 Jan 30. Epub 2018 Jan 30.
    Departments of Nephrology Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
    Insufficient hemodynamics during agonal phase-i.e. the period between withdrawal of life-sustaining treatment and circulatory arrest-in Maastricht category III circulatory-death donors (DCD) potentially exacerbate ischemia/reperfusion injury. Read More

    The Effects of Brain Death and Ischemia on Tolerance Induction are Organ-Specific.
    Am J Transplant 2018 Jan 29. Epub 2018 Jan 29.
    Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
    We have previously shown that 12 days of high-dose calcineurin inhibition induced tolerance in MHC inbred miniature swine receiving MHC-mismatched lung, kidney, or co-transplanted heart/kidney allografts. However, if lung grafts were procured from brain dead donors, and transplanted alone, they were rejected within 19-45 days. Here, we investigated whether donor brain death with or without allograft ischemia would also prevent tolerance induction in kidney or heart/kidney recipients. Read More

    CMV-infected kidney grafts drive the expansion of blood-borne CMV-specific T cells restricted by shared class I HLA molecules via presentation on donor cells.
    Am J Transplant 2018 Jan 27. Epub 2018 Jan 27.
    EA4245 Cellules dendritiques, Immunomodulation et Greffes, Université François-Rabelais, 10 Boulevard Tonnellé, 37032, Tours, France.
    We aimed to determine the role of cytomegalovirus (CMV)-infected donor cells in the development of a CMV-specific immune response in kidney transplant recipients. We assessed the CMV pp65-specific immune response by using interferon-ɣ ELISPOT and dextramers in peripheral blood mononuclear cells from 115 recipients (D+R- 31, D+R+ 44, D-R+ 40) late after transplantation (mean 59±42 months). Receiving a kidney from a D+ donor resulted in a higher number of IFN-ɣ-producing anti-CMV T-cells (p=0. Read More

    Biologic mechanisms and clinical consequences of pregnancy alloimmunization.
    Am J Transplant 2018 Jan 25. Epub 2018 Jan 25.
    University of Pennsylvania, Philadelphia PA, 3400 Spruce Street, One Founders Pavilion Philadelphia PA 19104.
    Alloimmunization occurs during pregnancy when tissue antigens derived from the fetus and/or placenta prime maternal immune cells to divide and differentiate. For many women, the result of pregnancy alloimmunization is the formation of anti-HLA antibody that can endure for decades and preclude transplantation by limiting donor compatibility. Pregnancy alloimmunization may also generate memory B cells that can rapidly produce anti-HLA antibody after transplantation as well as pathogenic memory T cells which pose a threat to graft survival. Read More

    Causes and Timing of End-Stage Renal Disease after Living Kidney Donation.
    Am J Transplant 2018 Jan 25. Epub 2018 Jan 25.
    Division of Renal Diseases and Hypertension, Houston Methodist Hospital, Houston, TX.
    End stage renal disease (ESRD) is a risk after kidney donation. We sought, in a large cohort of kidney donors to determine the causes of donor ESRD, the interval from donation to ESRD, the role of donor/recipient relationship, and the trajectory of the estimated GFR (eGFR) from donation to ESRD. Between 1/1/1963 thru 12/31/2015, 4030 patients underwent living donor nephrectomy at our center, and have had ascertainment of ESRD status. Read More

    Live nondirected uterus donors: Psychological characteristics and motivation for donation.
    Am J Transplant 2018 Jan 24. Epub 2018 Jan 24.
    Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, USA.
    Emerging research suggests that uterus transplantation is a viable option for women without a uterus who want to become pregnant and carry a child to term. Currently, no knowledge exists regarding nondirected uterus donors. This study (NCT 02656550) explored the baseline psychological characteristics of nondirected uterus donors at a single study site. Read More

    Ex vivo allotransplantation engineering: Delivery of mesenchymal stem cells prolongs rejection-free allograft survival.
    Am J Transplant 2018 Jan 23. Epub 2018 Jan 23.
    NYU Langone Health, Hansjörg Wyss Department of Plastic Surgery, New York, NY, USA.
    Current pharmacologic regimens in transplantation prevent allograft rejection through systemic recipient immunosuppression but are associated with severe morbidity and mortality. The ultimate goal of transplantation is the prevention of allograft rejection while maintaining recipient immunocompetence. We hypothesized that allografts could be engineered ex vivo (after allotransplant procurement but before transplantation) by using mesenchymal stem cell-based therapy to generate localized immunomodulation without affecting systemic recipient immunocompetence. Read More

    Heterogeneity of memory B cells.
    Am J Transplant 2018 Jan 23. Epub 2018 Jan 23.
    Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL, USA.
    Potential solid organ transplant recipients broadly sensitized to HLA have long wait times, low transplant rates and poor outcomes. The new kidney allocation system has improved access to the most highly sensitized recipients; however, their long-term outcomes are unknown. Emerging data suggest that memory B cell repertoire is broader than the plasma cell repertoire, therefore, despite refinements in anti-HLA antibody detection technology, donor-specific HLA- specific memory B cells may in fact be present in some, if not most, highly sensitized recipients with no detectable donor-specific antibodies. Read More

    Clostridium difficile infection is associated with graft loss in solid organ transplant recipients.
    Am J Transplant 2018 Jan 19. Epub 2018 Jan 19.
    Transplant Infectious Diseases Unit, University Hospitals Geneva, Geneva, Switzerland.
    Clostridium difficile infection (CDI) is a leading cause of infectious diarrhea in solid organ transplant recipients (SOT). We aimed to assess incidence, risk factors, and outcome of CDI within the Swiss Transplant Cohort Study (STCS). We performed a case-control study of SOT recipients in the STCS diagnosed with CDI between May 2008 and August 2013. Read More

    Establishment of practical recellularized liver graft for blood perfusion using primary rat hepatocytes and liver sinusoidal endothelial cells.
    Am J Transplant 2018 Jan 16. Epub 2018 Jan 16.
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
    Tissue decellularization produces a three-dimensional scaffold that can be used to fabricate functional liver grafts following recellularization. Inappropriate cell distribution and clotting during blood perfusion hinder the practical use of recellularized livers. Here we aimed to establish a seeding method for the optimal distribution of parenchymal and endothelial cells, and to evaluate the effect of liver sinusoidal endothelial cells (LSECs) in the decellularized liver. Read More

    Prospective randomized study of conversion from tacrolimus to cyclosporine A to improve glucose metabolism in patients with posttransplant diabetes mellitus after renal transplantation.
    Am J Transplant 2018 Jan 16. Epub 2018 Jan 16.
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium.
    Tacrolimus (TAC) increases the risk of posttransplant diabetes (PTDM) compared with cyclosporine A (CYC). The present 12-month, multicenter, investigator-driven, prospective, randomized study was designed to assess whether conversion from tacrolimus to CYC can reverse PTDM after renal transplantation. Predominantly white patients with PTDM according to the 2005 American Diabetes Association criteria were randomized to either replacement of TAC with CYC or continuation of their TAC-based regimen after stratification for type of glucose-lowering therapy, steroid therapy, and hepatitis C status. Read More

    Decreasing deceased donor transplant rates among children (≤6 years) under the new kidney allocation system.
    Am J Transplant 2018 Jan 15. Epub 2018 Jan 15.
    Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL, USA.
    The Kidney Allocation System (KAS) was implemented in December 2014 with unknown impact on the pediatric waitlist. To understand the effect of KAS on pediatric registrants, deceased donor kidney transplant (DDKT) rate was assessed using interrupted time series analysis and time-to-event analysis. Two allocation eras were defined with an intermediary washout period: Era 1 (01/01/2013-09/01/2014), Era 2 (09/01/2014-03/01/2015), and Era 3(03/01/2015-03/01/2017). Read More

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