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    6585 results match your criteria American Journal of Transplantation[Journal]

    1 OF 132

    Illicit Drug Use, Illicit Drug Use Disorders, and Drug Overdose Deaths in Metropolitan and Nonmetropolitan Areas-United States.
    Am J Transplant 2017 Dec;17(12):3241-3252
    National Center for Injury Prevention and Control, CDC, Atlanta, GA.
    Problem/condition: Drug overdoses are a leading cause of injury death in the United States, resulting in approximately 52,000 deaths in 2015. Understanding differences in illicit drug use, illicit drug use disorders, and overall drug overdose deaths in metropolitan and nonmetropolitan areas is important for informing public health programs, interventions, and policies.

    Reporting Period: Illicit drug use and drug use disorders during 2003-2014, and drug overdose deaths during 1999-2015. Read More

    Late graft failure after kidney transplantation as the consequence of late versus early events.
    Am J Transplant 2017 Nov 15. Epub 2017 Nov 15.
    University of Minnesota, Minneapolis, Minnesota.
    Beyond the first posttransplant year, 3% of kidney transplants fail annually. In a prospective, multicenter cohort study, we tested the relative impact of early versus late events on risk of long-term death-censored graft failure (DCGF). In grafts surviving at least 90 days, early events (acute rejection [AR] and delayed graft function [DGF] before day 90) were recorded; serum creatinine (Cr) at day 90 was defined as baseline. Read More

    Comments on "Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation".
    Am J Transplant 2017 Nov 15. Epub 2017 Nov 15.
    Oregon Health and Science University, Portland, OR.
    Using a retrospective cohort that was part of a donor intervention trial published in 2009 (1) , Schnuelle et al report in this issue that spontaneous hypothermia in deceased organ donors resulted in decreased recipient renal delayed graft function(2) . Allograft survival was not statistically significantly different during long-term follow up. While spontaneous hypothermia is likely a distinct physiologic process compared to targeted mild hypothermia, as in our previously reported randomized controlled trial(3) , the findings of the current retrospective study further confirm our impression that therapeutic mild hypothermia and deceased organ donor intervention research, in general, hold tremendous potential for addressing the ongoing shortage of organs available for transplantation. Read More

    Paneth and Intestinal Stem Cells Preserve their Functional Integrity during Worsening of Acute Cellular Rejection in Small Bowel Transplantation.
    Am J Transplant 2017 Nov 15. Epub 2017 Nov 15.
    Laboratorio de Investigación Traslacional e Inmunología Asociada al Trasplante, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Buenos Aires, Argentina.
    Graft survival after small bowel transplantation remains impaired due to acute cellular rejection (ACR), the leading cause of graft loss. Although it was shown that the number of enteroendocrine progenitor cells in intestinal crypts was reduced during mild ACR, no results of Paneth and intestinal stem cells localized at the crypt bottom have been shown so far. Therefore, we wanted to elucidate integrity and functionality of the Paneth and stem cells during different degrees of ACR, and to assess whether these cells are the primary targets of the rejection process. Read More

    Outcomes of Donation after Circulatory Death kidneys undergoing Hypothermic Machine Perfusion following Static Cold Storage: A UK population-based cohort study.
    Am J Transplant 2017 Nov 14. Epub 2017 Nov 14.
    Department of Renal Surgery, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.
    Evidence is currently lacking regarding the outcomes of kidneys undergoing Hypothermic Machine Perfusion (HMP) in the UK. Using the National Health Service Blood and Transplant database, the authors compared outcomes for recipients of single organ Donation after Circulatory Death (DCD) kidneys preserved with HMP to those using only static cold storage (SCS). Between 2007 and 2015, HMP was used in 19. Read More

    Primary Graft Dysfunction after Heart Transplantation: Incidence, Trends and Associated Risk Factors.
    Am J Transplant 2017 Nov 14. Epub 2017 Nov 14.
    Department of Anesthesiology, Duke University Medical Center, Durham, NC, 27710, USA.
    Changes in heart transplant (HT) donor and recipient demographics may influence the incidence of primary graft dysfunction (PGD). We conducted a retrospective study to evaluate PGD incidence, trends, and associated risk factors by analyzing consecutive adult patients who underwent HT between January 2009 and December 2014 at our institution. Patients were categorized as having PGD using the International Society of Heart and Lung Transplantation defined criteria. Read More

    Heme Oxygenase-1 Regulates Sirtuin-1 - Autophagy Pathway in Liver Transplantation: From Mouse-to-Human.
    Am J Transplant 2017 Nov 14. Epub 2017 Nov 14.
    The Dumont-UCLA Transplant Center, Department of Surgery, Division of Liver and Pancreas Transplantation.
    Liver ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and a key obstacle to expanding the donor pool in orthotopic liver transplantation (OLT). Although graft autophagy is essential for resistance against hepatic IRI, its significance in clinical OLT remains unknown. Despite recent data identifying heme oxygenase-1 (HO-1) as a putative autophagy inducer, its role in OLT and interactions with Sirtuin-1 (SIRT1), a key autophagy regulator, have not been studied. Read More

    IL-7 Receptor Heterogeneity as a Mechanism for Repertoire Change during Post-Depletional Homeostatic Proliferation and its Relation to Costimulation Blockade-Resistant Rejection.
    Am J Transplant 2017 Nov 14. Epub 2017 Nov 14.
    Department of Surgery, Duke University Medical Center, Durham, NC.
    Kidney transplant patients treated with belatacept without depletional induction experience higher rates of acute rejection compared to patients treated with conventional immunosuppression. Costimulation blockade-resistant rejection (CoBRR) is associated with terminally differentiated T cells. Alemtuzumab induction and belatacept/sirolimus immunotherapy effectively prevents CoBRR. Read More

    The First Case of Ischemia-free Organ Transplantation in Humans: A Proof of Concept.
    Am J Transplant 2017 Nov 10. Epub 2017 Nov 10.
    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
    Ischemia and reperfusion injury (IRI) is an inevitable event in conventional organ transplant procedure and is associated with significant mortality and morbidity post-transplantation. We hypothesize that IRI is avoidable if the blood supply for the organ is not stopped, thus resulting in optimal transplant outcomes. Here we described the first case of a novel procedure called ischemia-free organ transplantation (IFOT) for patients with end-stage liver disease. Read More

    Erythropoietic protoporphyria in an adult with sequential liver and hematopoietic stem cell transplantation: A case report.
    Am J Transplant 2017 Nov 8. Epub 2017 Nov 8.
    Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine.
    Erythropoieitic protoporphyria (EPP) is a rare inherited disorder of the heme biosynthesis pathway resulting in the accumulation of protoporphyrins in the blood, erythrocytes, and other tissues. Because of a gene mutation in the FECH gene, ferrochelatase, the enzyme involved in the final step of heme synthesis, is deficient in these patients. While the major symptom of this disorder is photosensitivity, rarely, it can cause progressive liver disease requiring liver transplantation (LT). Read More

    Emergency Department Utilization among Kidney Transplant Recipients in the United States.
    Am J Transplant 2017 Nov 8. Epub 2017 Nov 8.
    Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA.
    Patients with End Stage Renal Disease (ESRD) use the emergency department (ED) at a 6-fold higher rate than U.S. adults. Read More

    Functional status, healthcare utilization, and the costs of liver transplantation.
    Am J Transplant 2017 Nov 8. Epub 2017 Nov 8.
    Division of Transplant Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
    The Model for End-stage Liver Disease (MELD) score predicts higher transplant healthcare utilization and costs; however, the independent contribution of functional status towards costs is understudied. The study objective was to evaluate the association between functional status, as measured by Karnofsky Performance Status (KPS), and liver transplant (LT) costs in the first post-transplant year. In a cohort of 598 LT recipients from 7/1/2009-11/30/2014, multivariable models assessed associations between KPS and outcomes. Read More

    Salvage therapy with topical posaconazole in lung transplant recipients with invasive scedosporium infection.
    Am J Transplant 2017 Nov 8. Epub 2017 Nov 8.
    Microbiology Unit, La Fe University and Polytechnic Hospital, Valencia, Spain.
    Scedosporium is an important pathogen in cystic fibrosis (CF) and post-transplant, but it rarely causes invasive infection. Treatment remains challenging, particularly due to the inherent resistance to multiple antifungal agents. We present three complicated invasive tracheobronchial and lung Scedosporium apiospermum infections following lung transplant. Read More

    Turn Down for What? Patient Outcomes Associated with Declining Increased Infectious Risk Kidneys.
    Am J Transplant 2017 Nov 8. Epub 2017 Nov 8.
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
    Transplant candidates who accept a kidney labeled increased risk for disease transmission (IRD) accept a low risk of window period infection, yet those who decline must wait for another offer that might harbor other risks or never even come. To characterize survival benefit of accepting IRD kidneys, we used 2010-2014 SRTR data to identify 104,998 adult transplant candidates who were offered IRD kidneys that were eventually accepted by someone; the median (IQR) KDPI of these kidneys was 30 (16-49). We followed patients from the offer decision until death or end-of-study. Read More

    The Utilisation of Boari Flap Vesicocalycostomy (BFV) for Salvage Repair of Kidney Transplant Ureteric Injury after Robotic Radical Prostatectomy (RRP).
    Am J Transplant 2017 Nov 8. Epub 2017 Nov 8.
    Department of Urology, National University Hospital, 5 Lower Kent Ridge Road, Singapore, 119074.
    The prevalence of prostate carcinoma in kidney transplant male recipients approach 1.1% (1). Despite increasing reports of RRP performed for ageing kidney transplant recipients, there are no publications addressing post-operative complications including transplant ureteric injuries(2-3). Read More

    Screening for Zika Virus in Deceased Organ Donors in Florida.
    Am J Transplant 2017 Nov 8. Epub 2017 Nov 8.
    Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine.
    Zika virus (ZIKV) cases have been detected across the United States (US) and locally acquired cases have been reported in Florida. Currently, there are no ZIKV screening guidelines and no data on the incidence among organ donors in the US. This retrospective study was conducted at Jackson Memorial-Miami Transplant Institute. Read More

    Anti-CD47 Monoclonal Antibody Therapy Reduces Ischemia-Reperfusion Injury of Renal Allografts in a Porcine Model of Donation after Cardiac Death.
    Am J Transplant 2017 Oct 31. Epub 2017 Oct 31.
    Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO.
    We investigated whether blockade of the CD47 signaling pathway could reduce ischemia-reperfusion injury (IRI) of renal allografts donated after cardiac death (DCD) in a porcine animal model of transplantation. Renal allografts were subjected to 30 min of warm ischemia, 3.5 hours of cold ischemia and then perfused with a humanized anti-CD47 monoclonal antibody (CD47mAb) in the treatment group or HTK solution in the control group (n=4/group). Read More

    NAT Testing in Recipients of Hepatitis C Aviremic Donor Organs.
    Am J Transplant 2017 Oct 31. Epub 2017 Oct 31.
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington Medical Center, Seattle, Washington, United States.
    As outcomes of transplantation have improved, the number of transplant candidates listed for deceased donor transplantation has increased significantly over the years. Organ shortage is one of the greatest challenges facing the field of organ transplantation. Until recently, organs from donors who tested for hepatitis C virus (HCV) have been used exclusively in recipients with chronic HCV infection or were discarded at a high rate. Read More

    Postoperative Cognitive Dysfunction and Mortality following Lung Transplantation.
    Am J Transplant 2017 Oct 31. Epub 2017 Oct 31.
    Duke University Medical Center, Department of Medicine.
    Preliminary evidence suggests that postoperative cognitive dysfunction (POCD) is common following lung transplantation. The impact of POCD on clinical outcomes has yet to be studied. The association between POCD and longer term survival was therefore examined in a pilot study of post-transplant survivors. Read More

    The effect of match-run frequencies on the number of transplants and waiting times in kidney exchange.
    Am J Transplant 2017 Oct 31. Epub 2017 Oct 31.
    University of Toledo, OH.
    Numerous kidney exchange (kidney paired donor (KPD)) registries in the U.S have gradually shifted to high frequency match-runs, raising the question of whether this harms the number of transplants. We conduct simulations using clinical data from two KPD registries-the Alliance for Paired Donation, which runs multi-hospital exchanges, and Methodist San Antonio, which runs single center exchanges-to study how the frequency of match-runs impacts the number of transplants and the average waiting times. Read More

    T cell-mediated rejection is a major determinant of inflammation in scarred areas in kidney allografts.
    Am J Transplant 2017 Oct 31. Epub 2017 Oct 31.
    Paris Translational Research Center for Organ Transplantation, INSERM, UMR-S970, Paris, France.
    Inflammation in fibrosis areas (i-IF/TA) of kidney allografts is associated with allograft loss; however, its diagnostic significance remains to be determined. We investigated the clinicohistologic phenotype and determinants of i-IF/TA in a prospective cohort of 1539 kidney recipients undergoing evaluation of i-IF/TA and tubulitis in atrophic tubules (t-IF/TA) on protocol allograft biopsies performed at 1 year posttransplantation. We considered donor, recipient, and transplant characteristics, immunosuppression, and histological diagnoses in 2260 indication biopsies performed within the first year posttransplantation. Read More

    Factors associated with perceived donation-related financial burden among living kidney donors.
    Am J Transplant 2017 Oct 25. Epub 2017 Oct 25.
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    The perception of living kidney donation-related financial burden affects willingness to donate and the experience of donation, yet no existing tools identify donors who are at higher risk of perceived financial burden. We sought to identify characteristics that predicted higher risk of perceived financial burden. We surveyed 51 living kidney donors (LKDs) who donated from 01/2015 to 3/2016 about socioeconomic characteristics, predonation cost concerns, and perceived financial burden. Read More

    Longitudinal assessment of T cell inhibitory receptors in liver transplant recipients and their association with posttransplant infections.
    Am J Transplant 2017 Oct 25. Epub 2017 Oct 25.
    Immunobiology & Transplant Science Center, Houston Methodist Hospital, Houston, TX, USA.
    Current immunosuppression regimens in organ transplantation primarily inhibit T cells. However, T cells are also critical in protective immunity, especially in immune-compromised patients. In this study, we examined the association of T cell dysfunction, as marked by expression of T cell exhaustion molecules, and posttransplant infections in a cohort of liver transplant patients. Read More

    Validation of the Prognostic Power of the RETREAT Score for Hepatocellular Carcinoma Recurrence Using the UNOS Database.
    Am J Transplant 2017 Oct 25. Epub 2017 Oct 25.
    Division of Gastroenterology, Department of Medicine, University of California, San Francisco.
    A recent multi-center study developed and validated a novel prognostic index "Risk Estimation of Tumor Recurrence After Transplant (RETREAT)", which incorporates alpha-fetoprotein (AFP) at liver transplant (LT), microvascular invasion, and the sum of the largest viable tumor and number of tumors on explant. We now aim to evaluate RETREAT in the United Network for Organ Sharing (UNOS) database in hepatocellular carcinoma (HCC) patients meeting Milan criteria by imaging who underwent LT from 2012-2014. On explant (n=3276), 13% had microvascular invasion, 30% had no viable tumor, and 15% exceeded Milan criteria. Read More

    Immunoisolation of Murine Islet Allografts in Vascularized Sites Through Conformal Coating with Polyethylene Glycol.
    Am J Transplant 2017 Oct 25. Epub 2017 Oct 25.
    Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
    Islet encapsulation may allow transplantation without immunosuppression but thus far islets in large microcapsules transplanted in the peritoneal cavity failed to reverse diabetes in humans. We showed that islet transplantation in confined well-vascularized sites like the epididymal fat pad (EFP) improved graft outcomes, but only conformal coated (CC) islets can be implanted in these sites in curative doses. Here, we showed that CC using polyethylene glycol (PEG) and alginate (ALG) was not immunoisolating because of its high permselectivity and strong allogeneic T cell responses. Read More

    Outside-in HLA class I signaling regulates ICAM-1 clustering and endothelial-monocyte interactions via mTOR in transplant antibody-mediated rejection.
    Am J Transplant 2017 Oct 17. Epub 2017 Oct 17.
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles., Los Angeles, CA, USA.
    Antibody-mediated rejection (AMR) resulting in transplant allograft vasculopathy (TAV) is the major obstacle for long-term survival of solid organ transplants. AMR is caused by donor-specific antibodies to HLA which contribute to TAV by initiating outside-in signaling transduction pathways that elicit monocyte recruitment to activated endothelium. Mechanistic target of rapamycin (mTOR) inhibitors can attenuate TAV; therefore, we sought to understand the mechanistic underpinnings of mTOR signaling in HLA class I Ab-mediated endothelial cell activation and monocyte recruitment. Read More

    Macrophage subpopulations and their impact on chronic allograft rejection versus graft acceptance in a mouse heart transplant model.
    Am J Transplant 2017 Oct 17. Epub 2017 Oct 17.
    Immunobiology& Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, Texas.
    Macrophages infiltrating the allografts are heterogeneous, consisting of pro-inflammatory (M1 cells) as well as anti-inflammatory and fibrogenic phenotypes (M2 cells); they affect transplant outcomes via diverse mechanisms. Herein, we found that macrophage polarization into M1 and M2 subsets was critically dependent on TRAF6 and mTOR, respectively. In a heart transplant model we showed that macrophage-specific deletion of TRAF6 (LysM(C)(re) Traf6(fl/fl) ) or mTOR (LysM(C)(re) Mtor(fl/fl) ) did not affect acute allograft rejection. Read More

    Beneficial effect of recombinant rC1rC2 collagenases on human islet function: Efficacy of low dose enzymes on pancreas digestion and yield.
    Am J Transplant 2017 Oct 16. Epub 2017 Oct 16.
    Center for Cellular Transplantation, Cardiovascular Innovation Institute, Department of Surgery and Endocrinology, University of Louisville, Louisville, KY, 40202.
    High number of human islets can be isolated using modern purified tissue dissociation enzymes, however it requires using >20 Wunsch Unit (WU)/gram of pancreas for digestion. Attempts to reduce this dose have resulted in pancreas under-digestion and poor islet recovery but improved islet function. In this study, we achieved high number of functional islets using low dose of recombinant collagenase enzyme mixture (RCEM). Read More

    Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation.
    Am J Transplant 2017 Oct 12. Epub 2017 Oct 12.
    Vth Department of Medicine, University Medical Center Mannheim, Mannheim, Germany.
    A previous donor intervention trial found that therapeutic hypothermia reduced delayed graft function (DGF) after kidney transplantation. This retrospective cohort study nested in the randomized dopamine trial (ClinicalTrials. gov identifier: NCT000115115) investigates the effects of spontaneous donor hypothermia (core body temperature <36°C) on initial kidney graft function, and evaluates five-year graft survival. Read More

    Prevalence and outcomes of cystic lesions of the transplant pancreas: The University of Wisconsin Experience.
    Am J Transplant 2017 Oct 11. Epub 2017 Oct 11.
    Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
    Literature on the behavior of cystic lesions in pancreas transplants is scarce, and hence a better understanding is warranted. Data on recipients and their respective donors that underwent simultaneous kidney and pancreas, pancreas transplant alone, and pancreas after kidney between 1994 and 2015 were reviewed (n = 1185). Cystic lesions of the transplant pancreas developed in 22 patients (1. Read More

    Human papillomavirus and post-transplant cutaneous squamous-cell carcinoma: a multicenter, prospective cohort study.
    Am J Transplant 2017 Oct 11. Epub 2017 Oct 11.
    Institute of Virology, University of Cologne, Cologne, Germany.
    Organ-transplant recipients (OTR) have a 100-fold increased risk of cutaneous squamous-cell carcinoma (cSCC). We prospectively evaluated the association between beta-genus human-papillomaviruses (betaPV) and keratinocyte carcinoma in OTR. Two OTR cohorts without cSCC were assembled: cohort 1 transplanted in 2003-2006 (n=274) and cohort 2 in 1986-2002 (n=352). Read More

    Healthcare utilization after liver transplantation is highly variable among both centers and recipients.
    Am J Transplant 2017 Oct 11. Epub 2017 Oct 11.
    Division of Gastroenterology & Hepatology, University of Pennsylvania, Philadelphia, PA, USA.
    The relationship between healthcare utilization before and after liver transplantation (LT), and its association with center characteristics, is incompletely understood. This was a retrospective cohort study of 34 402 adult LTs between 2002 and 2013 using Vizient inpatient claims data linked to the United Network for Organ Sharing (UNOS) database. Multivariable mixed-effects linear regression models evaluated the association between hospitalization 90 days pre-LT and the number of days alive and out of the hospital (DAOH) 1 year post-LT. Read More

    Outcomes of organ transplants when the donor is a prior recipient.
    Am J Transplant 2017 Oct 9. Epub 2017 Oct 9.
    Division of Transplant, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
    Organ shortage continues to challenge the field of transplantation. One potential group of donors are those who have been transplant recipients themselves, or Organ Donation After Transplant (ODAT) donors. We conducted a retrospective cohort study to describe ODAT donors and to compare outcomes of ODAT grafts versus conventional grafts. Read More

    The role of C4d deposition in the diagnosis of antibody-mediated rejection after lung transplantation.
    Am J Transplant 2017 Oct 9. Epub 2017 Oct 9.
    Division of Pulmonary & Critical Care, Washington University School of Medicine, St Louis, MO, USA.
    Antibody-mediated rejection (AMR) is an increasingly recognized form of lung rejection. C4d deposition has been an inconsistent finding in previous reports and its role in the diagnosis has been controversial. We conducted a retrospective single-center study to characterize cases of C4d-negative probable AMR and to compare these to cases of definite (C4d-positive) AMR. Read More

    Urologic Malignancies in Kidney Transplantation.
    Am J Transplant 2017 Oct 6. Epub 2017 Oct 6.
    Department of Surgery Division of Transplantation, University of Alabama at Birmingham School of Medicine.
    With advances in immunosuppression, graft and patient outcomes after kidney transplantation have improved considerably. As a result, long-term complications of transplant, such as urologic malignancies, have become increasingly important. Kidney transplant recipients, for example, have a seven-fold risk of renal cell carcinoma (RCC) and three-fold risk of urothelial carcinoma (UC) compared to the general population. Read More

    Multidisciplinary approach to cardiac and pulmonary vascular disease risk assessment in liver transplantation: An evaluation of the evidence and consensus recommendations.
    Am J Transplant 2017 Oct 6. Epub 2017 Oct 6.
    Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
    Liver transplant (LT) candidates today are older, have greater medical severity of illness, and have more cardiovascular comorbidities than ever before. In addition, there are specific cardiovascular responses in cirrhosis that can be detrimental to the LT candidate. Cirrhotic cardiomyopathy, a condition characterized by increased cardiac output and a reduced ventricular response to stress, is present in up to 30% of patients with cirrhosis, thus challenging perioperative management. Read More

    A molecular biopsy test based on arteriolar under-hyalinosis reflects increased probability of rejection related to under-immunosuppression.
    Am J Transplant 2017 Oct 6. Epub 2017 Oct 6.
    Alberta Transplant Applied Genomics Centre Edmonton, Edmonton, AB, Canada.
    Calcineurin inhibitor immunosuppressive drugs induce changes such as arteriolar hyalinosis (ah) in kidney transplants, raising the possibility that molecular changes in biopsies related to histologic ah can provide information about drug exposure. We hypothesized that molecular changes associated with less-than-expected hyalinosis might highlight a subpopulation of patients with under-immunosuppression/nonadherence at intermediate times of biopsy posttransplant (TxBx). Using gene expression data from 562 indication biopsies, we developed a molecular classifier for predicting the expected ah lesions (Mah ) at a particular TxBx. Read More

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