4,979 results match your criteria American Journal of Translational Research[Journal]


Erratum: Influence of GLP-1 receptor agonist on insulin dosage and blood glucose control of patients with type 2 diabetes mellitus.

Am J Transl Res 2022 15;14(4):2767. Epub 2022 Apr 15.

Department of Endocrinology, Affiliated Hospital of Nantong University Nantong 226601, Jiangsu Province, China.

[This corrects the article on p. 11814 in vol. 13, PMID: 34786110. Read More

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Effects of silver foam combined with Dermlin wound healing dressing on inflammation and quality of life in patients with diabetic lower limb ulcers.

Am J Transl Res 2022 15;14(4):2452-2460. Epub 2022 Apr 15.

Wound Stoma Care Outpatient Center, The First Affiliated Hospital of Anhui Medical University Hefei 230022, Anhui, China.

Objective: To investigate the effects of silver foam combined with Dermlin wound healing dressing on concentrations of inflammatory factors of wound surface and quality of life of the patients with diabetic lower limb ulcers.

Methods: A total of 60 patients with diabetic lower limb ulcers admitted to the First Affiliated Hospital of Anhui Medical University during January 2020 and December 2020 were retrospectively enrolled in this study. According to the different treatments, they were divided into a control group (30 cases treated with Dermlin wound healing dressing only), and a research group (30 cases treated with silver foam combined with Dermlin dressing). Read More

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Anxiety and depression in graduating university students during the COVID-19 pandemic: a longitudinal study.

Am J Transl Res 2022 15;14(4):2668-2676. Epub 2022 Apr 15.

Department of Preventive Medicine, School of Public Health, Qiqihar Medical University Qiqihar 161006, China.

Objective: To investigate the prevalence of anxiety and depression in graduating university students during the COVID-19 pandemic and determine the associated factors.

Methods: A total of 681 graduating university students and 620 juniors enrolled in the first stage. The Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were used to measure anxiety and depression. Read More

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YY1 as a promoter regulating the circ_0001946/miR-671-5p/EGFR axis to promote chemotherapy resistance in breast cancer cells.

Am J Transl Res 2022 15;14(4):2550-2566. Epub 2022 Apr 15.

Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Jilin University Changchun 130021, Jilin Province, China.

Objective: To investigate the mechanism of circ_0001946 activated by transcription factor Yin Yang 1 (YY1), targeting miR-671-5p to regulate epidermal growth factor receptor (EGFR) and thereby participating in the chemotherapy resistance of breast cancer (BC) cells.

Methods: Circ_0001946, which is differentially expressed in BC, was screened using gene expression omnibus. Dual luciferase assay and RNA immunoprecipitation were conducted to verify the relationship among circ_0001946/miR-671-5p/EGFR. Read More

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Comparative analysis and influencing factors of hospitalization expenses of three single diseases in a tertiary Class A general hospital.

Am J Transl Res 2022 15;14(4):2480-2489. Epub 2022 Apr 15.

Medical Administration Division, The First Affiliated Hospital of Hebei North University Zhangjiakou 075000, Hebei, China.

Objective: To compare the hospitalization expenses among three single diseases in The First Affiliated Hospital of Hebei North University (a tertiary Class A general hospital), and analyze the factors affecting hospitalization costs, so as to provide some basis for controlling the unreasonable increase of hospitalization expenses as well as to render references for medical management.

Methods: By retrospective investigation, we selected the basic information of inpatient medical records and detailed billing of patients hospitalized in our hospital from Jan. 1, 2016 to Dec. Read More

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Effect of early olfactory training on olfactory recovery after nasal endoscopy in patients with chronic rhinosinusitis and olfactory impairment.

Am J Transl Res 2022 15;14(4):2600-2608. Epub 2022 Apr 15.

Department of Otorhinolaryngology Head and Neck, Tianjin Fourth Central Hospital Tianjin 300140, China.

Objective: To analyze the effect of early comprehensive olfactory rehabilitation training on olfactory recovery after nasal endoscopy in patients with chronic rhinosinusitis and olfactory impairment.

Methods: A retrospective study was conducted on 67 patients with chronic rhinosinusitis combined with olfactory impairment in our hospital from July 2018 to August 2020. Patients were divided into control group and observation group according to the time of implementing comprehensive olfactory rehabilitation training. Read More

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PNMA5 accelerated cellular proliferation, invasion and migration in colorectal cancer.

Am J Transl Res 2022 15;14(4):2231-2243. Epub 2022 Apr 15.

The First Affiliated Hospital of Gannan Medical University Ganzhou 341000, Jiangxi, PR China.

Objectives: Paraneoplastic antigen Ma family (PNMA) is dysregulated in the pathological development of various cancers. However, the actions of PNMA member 5 (PNMA5) in cancers are still unknown. The aim of this study was to explore the biological actions of PNMA5 and its implication in epithelial-mesenchymal transition (EMT) during the progression of colorectal cancer (CRC). Read More

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The correlation between lncRNA NEAT1 and serum hepcidin in the peripheral blood of non-alcoholic fatty liver disease patients.

Am J Transl Res 2022 15;14(4):2593-2599. Epub 2022 Apr 15.

Operating Room, Cangzhou People's Hospital Cangzhou 061000, Hebei, China.

Objectives: To explore and analyze the correlation between lncRNA NEAT1 and serum hepcidin (HEPC) in the peripheral blood of non-alcoholic fatty liver disease patients.

Methods: 119 patients, confirmed to have non-alcoholic fatty liver disease (NAFLD) and admitted to our hospital from January 2017 to June 2019, were enrolled in the NAFLD group, and 100 healthy subjects during the same period were enrolled in the control group. We recorded the two groups' general information and routine laboratory examination results and performed correlation analyses on the lncRNA NEAT1 expressions in their peripheral blood mononuclear cells (PBMCs) and HEPC. Read More

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High expression of RASAL1, a hub gene in the progression of liver cancer, suggests a poor prognostis.

Am J Transl Res 2022 15;14(4):2540-2549. Epub 2022 Apr 15.

Department of Anesthesiology, Ningbo First Hospital 59 Liuting Street, Ningbo 315000, Zhejiang, China.

Objective: Liver cancer (LC) is a frequently occurring lethal malignancy worldwide, yet the molecular mechanisms of carcinogenesis and their development remain uncharacterized. In this study, bioinformatics methods were used to find candidate hub genes for prognosis assessment and clinical treatment of LC.

Methods: Differential analysis was carried out based on the evidence of gene expression profiling in LC on The Cancer Genome Atlas (TCGA). Read More

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Screening of key genes associated with m6A methylation in diabetic nephropathy patients by CIBERSORT and weighted gene coexpression network analysis.

Am J Transl Res 2022 15;14(4):2280-2290. Epub 2022 Apr 15.

Department of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou, China.

Diabetic nephropathy (DN) is a common complication of diabetes. Due to its complex pathogenesis, there is no effective treatment. M6A is a newly discovered epigenetic mechanism that may be involved in the development of diabetic nephropathy. Read More

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Changes in transepithelial electrical resistance and intracellular ion concentration in TGF-β-induced epithelial-mesenchymal transition of retinal pigment epithelial cells.

Am J Transl Res 2022 15;14(4):2728-2738. Epub 2022 Apr 15.

Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.

Objective: This study aimed to investigate the changes in transepithelial electrical resistance (TEER) and ion concentrations, and their relationship in TGF-β-induced epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells.

Methods: RPE cell line ARPE-19 was employed and treated with 10 ng/ml TGF-β1 and TGF-β2 to establish the EMT model . The EMT markers fibronectin, N-cadherin, occludin, zona occludens 1(ZO-1) and claudin-19 were investigated by western blot and immunofluorescence. Read More

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Factors influencing quality of life and work of male nurses in Hainan Province: logistic regression analysis.

Am J Transl Res 2022 15;14(4):2367-2375. Epub 2022 Apr 15.

Operating Room, The First Affiliated Hospital of Hainan Medical University Haikou 570102, Hainan, China.

Objective: The purpose of this study was to explore the factors affecting the quality of life and work of male nurses in Hainan Province, so as to provide a theoretical basis to improve the motivation of male nurses, reduce job-hopping intentions, and maintain the stability of labor force.

Methods: A total of 393 male and 393 female nurses with registered nurse qualifications from 53 hospitals in Hainan Province were selected as the research subjects. The distribution in various hospital departments, quality of life, stress coping ability, social support and job satisfaction were compared. Read More

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LINC01272 activates epithelial-mesenchymal transition through miR-153-5p in Crohn's disease.

Am J Transl Res 2022 15;14(4):2331-2342. Epub 2022 Apr 15.

Department of Gastroenterology, The Affiliated Jiangning Hospital of Nanjing Medical University Nanjing 211100, Jangsu, China.

Objectives: Long noncoding RNAs (lncRNAs) have different functions in different diseases. There is little research on the functions of lncRNAs in Crohn's disease (CD). By using RNA-seq technology, we identified a lncRNA associated with Crohn's disease. Read More

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Research on antibody changes and nucleic acid clearance in COVID-19 patients treated with convalescent plasma.

Am J Transl Res 2022 15;14(4):2655-2667. Epub 2022 Apr 15.

The Eighth Affiliated Hospital of Xinjiang Medical University Urumqi 830013, Xinjiang, China.

Purpose: To investigate changes in the production of IgM and IgG antibodies and the negative transformation of viral nucleic acids in COVID-19 patients after convalescent plasma therapy, and also to discuss the clinical therapeutic effect, so as to provide a basis for the treatment of COVID-19 using specific antibodies.

Methods: The convalescent plasma of recovered patients from COVID-19 was used to treat other patients, and the levels of antibodies IgM and IgG and the nucleic acid genes ORF1ab and N in the patients were tested regularly for statistical comparison and analysis.

Results: In general, the Ct value and concentration of IgM and IgG antibodies in the plasma infusion group were significantly higher (1-3 times higher) than those in the non-plasma infusion group, respectively, but these differences were not significant (P>0. Read More

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Emerging role of epigenetic regulations in periodontitis: a literature review.

Authors:
Jing Huang Yi Zhou

Am J Transl Res 2022 15;14(4):2162-2183. Epub 2022 Apr 15.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University Wuhan 430079, China.

Periodontitis is mainly initiated by periodontal pathogens including , and bad living habits such as smoking aggravate its incidence and severity. The development of periodontitis is closely related to the host's immune responses and the secretion of various cytokine networks. Moreover, periodontitis has an important connection with the development of systemic diseases. Read More

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Effects of total laparoscopic hysterectomy on the clinical outcomes of patients with uterine fibroids.

Am J Transl Res 2022 15;14(4):2402-2409. Epub 2022 Apr 15.

Department of Gynecology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University) Haikou 571003, Hainan Province, China.

Objective: To clarify the effects of total laparoscopic hysterectomy (TLH) on sex hormone levels, quality of life (QOL) and complications such as lower-extremity deep vein thrombosis (DVT) in patients with uterine fibroids (UFs).

Methods: In this retrospective study, 136 patients with UFs treated in Hainan General Hospital from March 2018 to December 2020 were collected as research participants, of which 65 patients received total abdominal hysterectomy (TAH) were included in the control group and 71 patients who received TLH were assigned to the research group. The two groups were compared regarding the following items: response rate, surgical indexes, rehabilitation indicators, changes in sex hormone levels and QOL, and the occurrence of lower-extremity DVT. Read More

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Comparison of clinical efficacy and safety of transvaginal natural endoscopic surgery and transumbilical single port laparoscopy surgery for endometrial cancer.

Am J Transl Res 2022 15;14(4):2647-2654. Epub 2022 Apr 15.

Department of Gynecology, Fuzhou Second Hospital, Fuzhou Second Hospital of Xiamen University, School of Medicine, Xiamen University China.

Objective: To explore the difference in clinical efficacy and safety of transvaginal and transumbilical single port laparoscopy for endometrial cancer.

Methods: We retrospectively included 100 endometrial cancer patients who were admitted to the Fuzhou Second Hospital for surgical treatment from September 2020 to September 2021 and divided them into two groups according to different surgical treatment options. Patients in Group A (48 cases) were treated with transvaginal natural endoscopic surgery (TNES), and those in Group B (52 cases) were with transumbilical single port laparoscopic surgery (TSPLS). Read More

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Overexpression of galectin2 (LGALS2) predicts a better prognosis in human breast cancer.

Am J Transl Res 2022 15;14(4):2301-2316. Epub 2022 Apr 15.

Department of Oncology, The First Affiliated Hospital of Shantou University Medical College Shantou 515041, Guangdong, China.

Background: Galectins (LGALS) are a family of carbohydrate-binding proteins, and LGALS family members have shown prognostic roles in various types of cancers. However, the prognostic significance of some LGALS family members has not been studied in breast malignancy.

Methods: The prognostic value of LGALS family mRNA expression in breast cancer patients was investigated according to distinct clinicopathological features (including lymph node, intrinsic subtype, pathological grade, HER2, and TP53 status) using the Kaplan-Meier plotter database. Read More

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The curative effect of Shenfu-injection in the treatment of burn sepsis and its effect on the patient's immune function, HMGB, and vWF.

Am J Transl Res 2022 15;14(4):2428-2435. Epub 2022 Apr 15.

Department of Emergency Medicine, Binzhou Medical University Hospital Binzhou 256603, Shandong, China.

Objective: To investigate and analyze the immune regulatory effect of Shenfu-Injection (SFI) on patients with burn-injured sepsis by monitoring the serum level of high mobility group box 1 (HMGB1) and von Willebrand factor (vWF).

Methods: In this retrospective study, the Acute Physiology and Chronic Health Evaluation (APACHE II) score, Marshall score, peripheral blood T lymphocyte count, and NK cell concentration, levels of cytokines such as HMGB-1, and vWF in peripheral blood before and after treatment in patients from the control group (convention treatments, n=51) and the observation group (convention treatments plus SFI treatment, n=57) were analyzed. The prognosis of the two groups of patients at 28 days was analyzed and compared. Read More

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The Haoqin-Huaban formula alleviates UVB-induced skin damage through HOXA11-AS-mediated stabilization of EZH2.

Am J Transl Res 2022 15;14(4):2212-2230. Epub 2022 Apr 15.

Department of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University Beijing 100010, China.

Exposure of skin to ultraviolet B (UVB) irradiation induces oxidative damage, immune suppression, inflammation, and skin cancer. Recently, an increase in the use of traditional Chinese medicine decoction with antioxidant properties has emerged as protection for skin tissues against UVB-induced damage. The aim of this study was to investigate mechanisms of the protective effect of the Haoqin-Huaban formula (HQHB) on UVB-induced skin damage. Read More

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Comparison of Intra- and postoperative effectiveness of erector spinae plane block and patient controlled analgesia in patients undergoing coronary artery bypass grafting surgery.

Am J Transl Res 2022 15;14(4):2469-2479. Epub 2022 Apr 15.

Department of Anesthesiology and Reanimation, Bursa Uludağ University Faculty of Medicine Bursa 16059, Turkey.

The aim of our study was to compare bilateral erector spinae plane block (ESPB) efficacy on pain management with patient controlled analgesia (PCA) during the perioperative period in patients scheduled for coronary artery bypass grafting (CABG). After ethics committee approval (2019-7/31 dated 09.04. Read More

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Trend analysis of drug overdose deaths before and during the COVID-19 pandemic.

Am J Transl Res 2022 15;14(4):2685-2688. Epub 2022 Apr 15.

Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital/Harvard Medical School Boston, MA, USA.

Data from a single state indicated there was an increase in opioid overdose related emergency services during the COVID-19 pandemic. The current study examined the provisional rolling 12-month drug overdose deaths between January 2019 and October 2021 at the national, state, and specific-drug levels, to identify trends in drug-overdose deaths before and during the COVID-19 pandemic. The trend in provisional U. Read More

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Endoscopic- versus x-ray-guidance for placement of nasojejunal tubes in critically ill patients: a systematic review and meta-analysis of randomized controlled trials.

Am J Transl Res 2022 15;14(4):2134-2146. Epub 2022 Apr 15.

Surgery Department, Huzhou Central Hospital, Affiliated Central Hospital, Huzhou University Huzhou 313000, Zhejiang, China.

Nasojejunal tubes (NJTs) are increasingly used in critically ill patients. NJT insertion with endoscopic- or x-ray-guidance can be achieved with success rates above 90%. This systematic review and meta-analysis of randomized controlled trials (RCTs) compares the efficiency and safety of these two methods in critically ill patients. Read More

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Association between chronic kidney disease and cancer including the mortality of cancer patients: national health and nutrition examination survey 1999-2014.

Am J Transl Res 2022 15;14(4):2356-2366. Epub 2022 Apr 15.

Department of Nephrology, Division of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, China.

Purpose: This study aimed to investigate the association between chronic kidney disease (CKD) and different types of cancer and the effect of CKD on mortality among types of cancer.

Methods: 30559 participants from NHANES 1999-2014 were included in our analysis, which had 2824 participants with cancer. Subgroups were grouped by cancer location. Read More

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The effects of vasopressin injection technique on ovarian reserve in laparoscopic cystectomy of bilateral ovarian endometrioma: a retrospective cohort study.

Am J Transl Res 2022 15;14(4):2343-2349. Epub 2022 Apr 15.

Department of Obstetrics and Gynecology, PLA Rocket Force Characteristic Medical Center Xinjiekou Outer Street 16#, Xicheng District, Beijing 100088, China.

Objective: To evaluate the effects of vasopressin injection technique (VIT) on ovarian reserve in laparoscopic cystectomy of bilateral ovarian endometrioma.

Material And Methods: A total of 122 patients with bilateral ovarian endometrioma undergoing laparoscopic cystectomy were assigned to control or the VIT group. Coagulation-event count and blood loss were recorded. Read More

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Clinical characteristics and prognostic factors of lymphoma patients initially presenting with fever of unknown origin.

Am J Transl Res 2022 15;14(4):2625-2636. Epub 2022 Apr 15.

Department of Hematology, Huadong Hospital, Fudan University Shanghai, China.

Background: Lymphoma has been identified as the most common cause of non-infectious fever of unknown origin (FUO). However, clinical characteristics and prognostic factors in lymphoma patients with FUO are lacking.

Methods: From January 1, 2013 to December 31, 2019, our center enrolled 185 patients who initially presented with FUO but were later diagnosed with lymphoma in Huadong Hospital of Fudan University. Read More

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Laminoplasty and simultaneous C2 semi-laminectomy with internal fixation in treating ossification of the posterior longitudinal ligament in cervical discs at C2 segment.

Am J Transl Res 2022 15;14(4):2419-2427. Epub 2022 Apr 15.

Department of Orthopedic Surgery, The Third Hospital of Hebei Medical University Shijiazhuang 050035, Hebei Province, China.

Objective: To explore the effect of open-door laminoplasty and simultaneous C2 semi-laminectomy with lateral mass screw fixation (LSLF) in treating ossification of the posterior longitudinal ligament (OPLL) in cervical discs at C2 segment.

Methods: In this retrospective study, 76 patients diagnosed with OPLL in cervical discs at C2 segment from November 2016 to May 2019 were included. These patients were assigned into a LSLF group (n=41, LSLF surgery) and LF group (n=35, laminectomy and lateral mass screw fixation) according to the treatment they received. Read More

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The promising role and prognostic value of miR-198 in human diseases.

Am J Transl Res 2022 15;14(4):2749-2766. Epub 2022 Apr 15.

Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, Henan, P. R. China.

The importance of microRNAs (miRNAs or miRs) has attracted more and more attention. MiRNA is an approximately 22-nucleotide, single-stranded, non-coding RNA molecule that affects the expression of downstream target genes. MiRNAs regulate the occurrence and development of human diseases. Read More

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Morphometric analysis of the nasal septum in normal Chinese individuals using a three-dimensional model of the nasal septum with facial CT scanning.

Am J Transl Res 2022 15;14(4):2609-2616. Epub 2022 Apr 15.

Department of Otorhinolaryngology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine Shanghai, China.

Objectives: Three-dimensional (3D) models were reconstructed based on computed tomography (CT) scan data and to analyze the morphometric characteristics of the nasal septum in Chinese individuals.

Methods: Ninety-six healthy adults aged 20-83 years old without confirmed nasal disorders were enrolled in this study from 2014 to 2015. 3D models of the nasal septum were reconstructed based on their CT scan data, and 7 indices were used for the evaluation of the spacial structure of the nasal septum. Read More

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LncRNA TTN-AS1 confers tamoxifen resistance in breast cancer via sponging miR-107 to modulate PI3K/AKT signaling pathway.

Am J Transl Res 2022 15;14(4):2267-2279. Epub 2022 Apr 15.

Department of General Surgery, Affiliated Hospital of Nantong University Nantong 226001, Jiangsu, PR China.

Objective: Tamoxifen resistance of breast cancer (BC) is a significant hindrance in clinical therapy. The long-noncoding RNA (lncRNA) TTN-AS1 has been reported as a crucial tumor promoting factor in various cancers. In this study, we set out to discover the specific pathologic regulatory mechanisms of tamoxifen-resistance in breast cancer. Read More

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