Glomerular hyperpermeability after acute unilateral ureteral obstruction: Effects of Tempol, NOS-, RhoA- and Rac-1-inhibition.
Am J Physiol Renal Physiol 2018 Feb 21. Epub 2018 Feb 21.
Department of Nephrology, Lund University, Sweden.
It is well known that proteinuria following urinary tract obstruction is mainly of a tubular nature. Whether there are also changes in glomerular permeability is however unknown. In this study we compared glomerular sieving coefficients (θ) of polydisperse fluorescein isothiocyanate (FITC)-Ficoll 70/400 following 120 or 180 min unilateral ureteral obstruction (UUO) in anesthetized Sprague-Dawley rats. Read More