Distinct niches within the extracellular matrix dictate fibroblast function in (cell-free) 3D lung tissue cultures.
- Gerald Burgstaller,
- Arunima Sengupta,
- Sarah Vierkotten,
- Gerhard Preissler,
- Michael Lindner,
- Jürgen Behr,
- Melanie Königshoff,
- Oliver Eickelberg
Am J Physiol Lung Cell Mol Physiol 2018 Jan 18. Epub 2018 Jan 18.
Division of Respiratory Sciences and Critical Care Medicine, University of Colorado, United States.
Instructive cues from the extracellular matrix (ECM) and their functional interplay with cells play pivotal roles for development, tissue repair, and disease. However, the precise nature of this interplay remains elusive. We used an innovative 3D cell culture ECM model by decellularizing ex vivo lung tissue scaffolds (d3D-LTCs) derived from diseased and healthy mouse lungs, which widely mimics the native (patho)physiological in vivo microenvironment. Read More