10,182 results match your criteria American Journal of Physiology - Heart and Circulatory Physiology[Journal]


HIV and Cardiovascular Diseases Risk: Exploring the Interplay between T cell Activation, Coagulation, Monocyte Subsets and Lipid Subclass Alterations.

Am J Physiol Heart Circ Physiol 2019 Feb 15. Epub 2019 Feb 15.

Cardio-Metabolic Research Group (CMRG), Department of Physiological Sciences, Stellenbosch University, South Africa.

Although rollout of combined anti-retroviral treatment (cART) has blunted human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) onset, there is increased development of cardiovascular diseases (CVD) in HIV-infected individuals. While most HIV-infected individuals on cART achieve viral suppression, this may not necessarily result in complete immunological recovery. This study therefore evaluated T cell-mediated changes and coagulation markers in HIV-positive individuals to ascertain their potential to increase CVD risk. Read More

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http://dx.doi.org/10.1152/ajpheart.00797.2018DOI Listing
February 2019

B. anthracis Lethal Toxin but not Edema Toxin, Increases Pulmonary Artery Pressure and Permeability in Isolated Perfused Rat Lungs.

Am J Physiol Heart Circ Physiol 2019 Feb 15. Epub 2019 Feb 15.

Critical Care Medicine Department, National Institutes of Health, United States.

Introduction: Although lethal (LT) and edema toxin (ET) contribute to lethality during Bacillus anthracis infection, whether they increase vascular permeability and the extravascular fluid accumulation characterizing this infection is unclear. We employed an isolated perfused Sprague-Dawley rat lung model to investigate LT and ETs effects on pulmonary vascular permeability.

Methods And Results: Lungs (n≥6 per experimental group) were isolated, ventilated, suspended from a force transducer and perfused. Read More

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http://dx.doi.org/10.1152/ajpheart.00685.2018DOI Listing
February 2019

Pulmonary Vascular Mechanical Consequences of Ischemic Heart Failure and Implications for Right Ventricular Function.

Am J Physiol Heart Circ Physiol 2019 Feb 15. Epub 2019 Feb 15.

University of Wisconsin-Madison.

Motivation: Left heart failure (LHF) is the most common cause of pulmonary hypertension, which confers an increase in morbidity and mortality in this context. Pulmonary vascular resistance has prognostic value in LHF but otherwise the mechanical consequences of LHF for the pulmonary vasculature and right ventricle remain unknown. We sought to investigate mechanical mechanisms of pulmonary vascular and right ventricular dysfunction in a rodent model of LHF to address the knowledge gaps in understanding disease pathophysiology. Read More

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http://dx.doi.org/10.1152/ajpheart.00319.2018DOI Listing
February 2019
1 Read
3.838 Impact Factor

NRP1 regulates HMGB1 in vascular endothelial cells under high homocysteine condition.

Am J Physiol Heart Circ Physiol 2019 Feb 15. Epub 2019 Feb 15.

Center for Vascular Disease and Translational Medicine, The Third Xiangya Hospital of Central South University, China.

Endothelial inflammation plays an important role in hyperhomocysteinemia (HHcy)-associated vascular diseases. High mobility group box 1 (HMGB1) is a pro-inflammatory danger molecule produced by endothelial cells. However, whether HMGB1 was involved in vascular endothelial inflammation of HHcy is poorly understood. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00746.2018
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http://dx.doi.org/10.1152/ajpheart.00746.2018DOI Listing
February 2019
2 Reads

Proximal pressure reducing effect of wave reflection in the pulmonary circulation disappear in obstructive disease: insight from a rabbit model.

Am J Physiol Heart Circ Physiol 2019 Feb 15. Epub 2019 Feb 15.

IBiTech-bioMMeda, Ghent University, Belgium.

Locating the site of increased resistance within the vascular tree in pulmonary arterial hypertension (PAH), could assist in both patient diagnosis and tailoring treatment. Wave intensity analysis (WIA) is a wave analysis method that may be capable of localizing the major site of reflection within a vascular system. We investigated the contribution of WIA to the analysis of the pulmonary circulation in a rabbit model with animals subjected to variable occlusive pulmonary disease. Read More

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http://dx.doi.org/10.1152/ajpheart.00635.2018DOI Listing
February 2019
1 Read

Transient Receptor Potential Ankyrin-1 (TRPA1) Channel Contributes to Myocardial Ischemia-Reperfusion Injury.

Am J Physiol Heart Circ Physiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Medicine/Cardiology, University of Louisville, United States.

Myocardial ischemia-reperfusion (I/R) results in generation of free radicals, accumulation of lipid peroxidation-derived unsaturated aldehydes, variable angina (pain) and infarction. Transient receptor potential ankyrin-1 (TRPA1) mediates pain signaling and is activated by unsaturated aldehydes, including acrolein and 4-hydroxynonenal. The contribution of TRPA1 (a calcium permeable channel) to I/R-induced myocardial injury is unknown. Read More

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http://dx.doi.org/10.1152/ajpheart.00106.2018DOI Listing
February 2019

Left ventricular vortex and intraventricular pressure difference in dogs under various loading conditions.

Am J Physiol Heart Circ Physiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Veterinary Surgery, Tokyo University of Agriculture and Technology.

Restrictions on the conventional evaluation of diastolic function has been recognized especially under various loading conditions. Recently, new noninvasive ventricular vortex indexes have been introduced and are expected to reflect the cardiac function. Physiologically, there is a hypothesis that intraventricular pressure difference (IVPD) is related to the formation of vortexes. Read More

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http://dx.doi.org/10.1152/ajpheart.00686.2018DOI Listing
February 2019

Docosahexaenoic acid reduces resting blood pressure but increases muscle sympathetic outflow compared to eicosapentaenoic acid in healthy men and women.

Am J Physiol Heart Circ Physiol 2019 Feb 8. Epub 2019 Feb 8.

Human Health and Nutritional Sciences, University of Guelph, Canada.

Supplementation with monounsaturated or omega-3 polyunsaturated fatty acids (n-3 PUFA) can lower resting blood pressure (BP) and reduce the risk of cardiovascular events. The independent contributions of n-3 PUFA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on BP, and mechanisms responsible, are unclear. We tested whether EPA, DHA, and olive oil (OO), a source of monounsaturated fat, differentially affect resting hemodynamics and muscle sympathetic nerve activity (MSNA). Read More

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http://dx.doi.org/10.1152/ajpheart.00677.2018DOI Listing
February 2019

Overexpression of fatty acid binding protein 3 promotes remodeling after myocardial infarction by inducing apoptosis.

Am J Physiol Heart Circ Physiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China.

Objective: Fatty acid binding protein 3 (FABP3), a low-molecular-weight protein, participates in lipid transportation, storage, signaling transduction, oxidation, and transcription regulation. Here, we investigated the expression and function of FABP3 in ischemic heart diseases and explored the mechanisms by which FABP3 affected the remodeling after myocardial infarction (MI). Approach and Results:We showed that ischemic or hypoxic conditions upregulated FABP3 expression in vivo and in vitro. Read More

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http://dx.doi.org/10.1152/ajpheart.00360.2018DOI Listing
February 2019
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Differential control of muscle sympathetic outflow in single units of humans: a role for pulmonary artery baroreceptors?

Am J Physiol Heart Circ Physiol 2019 Feb;316(2):H430-H431

Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , United Kingdom.

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http://dx.doi.org/10.1152/ajpheart.00817.2018DOI Listing
February 2019

Corrigendum.

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Am J Physiol Heart Circ Physiol 2019 Feb;316(2):H432

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http://dx.doi.org/10.1152/ajpheart.zh4-2504-corr.2019DOI Listing
February 2019

CORRIGENDUM.

Authors:

Am J Physiol Heart Circ Physiol 2019 Feb;316(2):H433

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http://dx.doi.org/10.1152/ajpheart.zh4-2619-corr.2019DOI Listing
February 2019

Cardiovascular injury induced by tobacco products: Assessment of risk factors and biomarkers of harm A Tobacco Center of Regulatory Science (TCORS) Compilation.

Am J Physiol Heart Circ Physiol 2019 Feb 1. Epub 2019 Feb 1.

American Heart Association Tobacco Regulation and Addiction Center, University of Louisville, Louisville, KY.

Although substantial evidence shows that smoking is positively and robustly associated with cardiovascular disease (CVD), the CVD risk associated with the use of new and emerging tobacco products such as electronic cigarettes, hookah and heat-not-burn products remains unclear. This uncertainty stems from lack of knowledge on how the use of these products affects cardiovascular health. Cardiovascular injury associated with the use of new tobacco products could be evaluated by measuring changes in biomarkers of cardiovascular harm that are sensitive to the use of combustible cigarettes. Read More

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http://dx.doi.org/10.1152/ajpheart.00591.2018DOI Listing
February 2019
1 Read

Right Ventricular Remodeling in Response to Volume Overload in Fetal Sheep.

Am J Physiol Heart Circ Physiol 2019 Feb 1. Epub 2019 Feb 1.

Knight Cardiovascular Institute, Oregon Health & Sciences University, United States.

The fetal myocardium is known to be sensitive to hemodynamic load, responding to systolic overload with cellular hypertrophy, proliferation and accelerated maturation. However, the fetal cardiac growth response to primary volume overload is unknown. We hypothesized that increased venous return would stimulate fetal cardiomyocyte proliferation and terminal differentiation, particularly in the right ventricle (RV). Read More

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http://dx.doi.org/10.1152/ajpheart.00439.2018DOI Listing
February 2019

The Renin-Angiotensin System: Going Beyond the Classical Paradigms.

Am J Physiol Heart Circ Physiol 2019 Feb 1. Epub 2019 Feb 1.

Max-Delbrück-Center for Molecular Medicine (MDC), Berlin-Buch, Germany, Germany.

Thirty years ago a novel axis of the renin-angiotensin system (RAS) was unveiled by the discovery of angiotensin (Ang)-(1-7) generation in-vivo. Later angiotensin-converting enzyme 2 (ACE2) was shown to be the main mediator of this reaction and Mas was found to be the receptor for the heptapeptide. The functional analysis of this novel axis of the RAS which followed its discovery revealed numerous protective actions in particular for cardiovascular diseases. Read More

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http://dx.doi.org/10.1152/ajpheart.00723.2018DOI Listing
February 2019

Important roles of endothelial caveolin-1 in endothelium-dependent hyperpolarization and ischemic angiogenesis in mice.

Am J Physiol Heart Circ Physiol 2019 Feb 1. Epub 2019 Feb 1.

Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan.

Although increased levels of reactive oxygen species (ROS) are involved in the pathogenesis of cardiovascular diseases, the importance of physiological ROS has also been emerging. We have previously demonstrated that endothelium-derived hydrogen peroxide (HO) is one of endothelium-dependent hyperpolarization (EDH) factors and that loss of endothelial caveolin-1 reduces EDH/HO in microcirculation. Caveolin-1 (Cav-1) is a scaffolding/ regulatory protein that interacts with diverse signaling pathways including angiogenesis. Read More

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http://dx.doi.org/10.1152/ajpheart.00589.2018DOI Listing
February 2019

Sympatho-excitation in Response to Cardiac and Pulmonary Afferent Stimulation of TRPA1 Channels is Attenuated in Chronic Heart Failure Rats.

Am J Physiol Heart Circ Physiol 2019 Feb 1. Epub 2019 Feb 1.

Departmentof Anesthesiology, University of Nebraska Medical Center, United States.

Excessive sympatho-excitation characterizes the chronic heart failure (CHF) state. An exaggerated cardiac sympathetic afferent reflex (CSAR) contributes to this sympatho-excitation. Prior studies demonstrate that the CSAR to capsaicin (TRPV1 agonist) is exaggerated in CHF animal models. Read More

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http://dx.doi.org/10.1152/ajpheart.00696.2018DOI Listing
February 2019

Solving a century‑old conundrum underlying cardiac force‑length relations.

Am J Physiol Heart Circ Physiol 2019 Feb 1. Epub 2019 Feb 1.

Auckland Bioengineering Institute, The University of Auckland, New Zealand.

In the late 19 Century, Otto Frank presented a diagram showing that cardiac end‑systolic pressure‑volume relations are dependent on the mode of contraction: one for isovolumic contractions that locates above that for afterloaded ejecting contractions. Conflicting results to Frank's have been subsequently demonstrated in various species both within and among preparations ranging from the whole‑hearts to single myocytes, showing a single pressure‑volume or force‑length relation that is independent of the mode of contraction. Numerous explanations for these conflicting results have been proposed but are mutually contradictory and, hence, unsatisfying. Read More

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http://dx.doi.org/10.1152/ajpheart.00763.2018DOI Listing
February 2019

Sex Differences in Cerebral Autoregulation is Unaffected by Menstrual Cycle Phase in Young, Healthy Women.

Am J Physiol Heart Circ Physiol 2019 Feb 1. Epub 2019 Feb 1.

Pharmacology, Physiology & Neuroscience, Rutgers New Jersey Medical School, United States.

Sex is known to affect the prevalence of conditions such as stroke. However, effects of sex on cerebral blood flow regulation are still not well understood. Critical to this understanding is how fluctuations in hormones across the menstrual cycle affect cerebral autoregulation. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00474.2018
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http://dx.doi.org/10.1152/ajpheart.00474.2018DOI Listing
February 2019
1 Read

Modulating Cardiac Conduction during Metabolic Ischemia with Perfusate Sodium and Calcium in Guinea Pig Hearts.

Am J Physiol Heart Circ Physiol 2019 Feb 1. Epub 2019 Feb 1.

Virginia Tech Carilion Fralin Biomedical Research Institute, Center for Heart and Regenerative Medicine Research, School of Biomedical Engineering and Science, Virginia Tech, United States.

Introduction: We previously demonstrated that altering extracellular sodium (Na) and calcium (Ca) can modulate a form of electrical communication between cardiomyocytes, termed ephaptic coupling, especially during loss of gap junction coupling. We hypothesized that altering Na and Ca modulates conduction velocity (CV) and arrhythmic burden during ischemia.

Methods: Electrophysiology was quantified by optically mapping Langendorff-perfused guinea pig ventricles with modified Na (147 or 155mM) and Ca (1. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00083.2018
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http://dx.doi.org/10.1152/ajpheart.00083.2018DOI Listing
February 2019
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Exogenous Ubiquitin Reduces Inflammatory Response and Preserves Myocardial Function 3 days Post Ischemia/Reperfusion Injury.

Am J Physiol Heart Circ Physiol 2019 Jan 25. Epub 2019 Jan 25.

Biomedical Sciences, East Tennessee State University, United States.

β-adrenergic receptor (β-AR) stimulation increases extracellular levels of ubiquitin (UB) in myocytes, and exogenous UB decreases β-AR-stimulated myocyte apoptosis and myocardial fibrosis. Here, we hypothesized that exogenous UB modulates inflammatory response, thereby playing a protective role in cardiac remodeling following ischemia/reperfusion (I/R) injury. C57Bl/6 mice, infused with vehicle or UB (1mg/g/h), were subjected to myocardial I/R injury. Read More

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http://dx.doi.org/10.1152/ajpheart.00654.2018DOI Listing
January 2019
1 Read

Testosterone and Cardiac Remodeling: Why are Older Men Susceptible to Heart Disease?

Am J Physiol Heart Circ Physiol 2019 Jan 25. Epub 2019 Jan 25.

Medicine, University of Alberta, Canada.

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http://dx.doi.org/10.1152/ajpheart.00046.2019DOI Listing
January 2019

A ADENOSINE RECEPTOR AND MITOCHONDRIA: TARGETS OF REMOTE ISCHEMIC PRECONDITIONING.

Am J Physiol Heart Circ Physiol 2019 Jan 25. Epub 2019 Jan 25.

Pathology, Faculty of Medicine, Institute of Cardiovascular Physiopathology, Argentina.

Adenosine is involved in classic preconditioning in most species and acts especially through adenosine A and A receptors. The aim of our study was to evaluate whether remote ischemic preconditioning (rIPC) activates A adenosine receptors and improves mitochondrial function, thereby reducing myocardial infarct size. Isolated rat hearts were subjected to 30 min of global ischemia and 60 min of reperfusion (I/R). Read More

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http://dx.doi.org/10.1152/ajpheart.00071.2018DOI Listing
January 2019
1 Read

Insights into the mechanism of paradoxical low-flow low-pressure-gradient severe aortic stenosis: association with reduced oxygen consumption by the whole body.

Am J Physiol Heart Circ Physiol 2019 Jan 25. Epub 2019 Jan 25.

Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan.

The mechanism of reduced stroke volume index (SVi) in paradoxical low-flow low-pressure-gradient (PLFLPG) aortic stenosis (AS) remains unclarified. Guyton et al. demonstrated that the SVi is determined by whole-body oxygen consumption (VO) in many subjects, including patients with heart disease. Read More

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http://dx.doi.org/10.1152/ajpheart.00715.2018DOI Listing
January 2019
2 Reads

Activation of Notch signalling by soluble Dll4 decreases vascular permeability via a cAMP/PKA-dependent pathway.

Am J Physiol Heart Circ Physiol 2019 Jan 25. Epub 2019 Jan 25.

Division of Cancer and Stem Cells, School of Medicine, Unviersity of Nottingham.

The Notch ligand Delta-like ligand 4 (Dll4), upregulated by Vascular Endothelial Growth Factor (VEGF), is a key regulator of vessel morphogenesis and function, controlling tip and stalk cell selection during sprouting angiogenesis. Inhibition of Dll4 results in hyper-sprouting, non-functional, poorly perfused vessels, suggesting a role for Dll4 in formation of mature, reactive, functional vessels, with low permeability and able to restrict fluid and solute exchange. We tested the hypothesis that Dll4 controls transvascular fluid exchange. Read More

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http://dx.doi.org/10.1152/ajpheart.00610.2018DOI Listing
January 2019

An Assessment of K Channel Function in Human Cerebral Arteries.

Am J Physiol Heart Circ Physiol 2019 Jan 25. Epub 2019 Jan 25.

University of Western Ontario, Canada.

In rodent cerebral circulation, inward-rectifying K (K) channels set resting tone and the distance over which electrical phenomena spread along the arterial wall. This study sought to translate these observations into human cerebral arteries obtained from resected brain tissue. Computational modeling and the conduction assay first defined the impact of K channels on electrical communication; patch-clamp electrophysiology, qPCR and immunohistochemistry then characterized K2. Read More

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http://dx.doi.org/10.1152/ajpheart.00022.2019DOI Listing
January 2019

Phosphodiesterase-4 Inhibition Reduces ECLS-Induced Vascular Permeability and Improves Microcirculation in a Rodent Model of Extracorporeal Resuscitation.

Am J Physiol Heart Circ Physiol 2019 Jan 25. Epub 2019 Jan 25.

Department of Anesthesiology and Critical Care, Medical Center - University of Freiburg, Faculty of Medicine, Germany.

Background: Extracorporeal circulation can be accompanied by increased vascular permeability leading to pathological fluid balance and organ dysfunction. The second messenger cAMP is involved in capillary permeability and maintaining endothelial integrity. The aim of this study is to evaluate the effect of phosphodiesterase-4 (PDE-4) inhibition on ECLS induced capillary leakage, microcirculatory dysfunction and organ injury. Read More

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http://dx.doi.org/10.1152/ajpheart.00673.2018DOI Listing
January 2019
2 Reads

miR-21-5p Regulates Mitochondrial Respiration and Lipid Content in H9C2 Cells.

Am J Physiol Heart Circ Physiol 2019 Jan 18. Epub 2019 Jan 18.

Physiology, Medical College of Wisconsin, United States.

Cardiovascular related pathologies are the single leading cause of death in chronic kidney disease (CKD) patients. Previously, we found that 5/6 nephrectomy model of CKD leads to an upregulation of miR-21-5p in the left ventricle, targeting peroxisome proliferator-activated receptor alpha (PPARα) and altering the expression of transcripts involved with fatty acid oxidation and glycolysis. In this study we evaluated the potential for knockdown or overexpression of miR-21-5p to regulate lipid content, peroxidation and mitochondrial respiration in H9C2 cells. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00538.2017
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http://dx.doi.org/10.1152/ajpheart.00538.2017DOI Listing
January 2019
4 Reads

Evidence for heterogeneous subsarcolemmal Na levels in rat ventricular myocytes.

Am J Physiol Heart Circ Physiol 2019 Jan 18. Epub 2019 Jan 18.

Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Norway.

Intracellular Na concentration ([Na]) regulates cardiac contractility. Previous studies suggest that subsarcolemmal [Na] is higher than cytosolic [Na] in cardiac myocytes, but this concept remains controversial. Here, we employed electrophysiological experiments and mathematical modeling to test whether there are subsarcolemmal pools with different Na concentrations and dynamics compared to the bulk cytosol in rat ventricular myocytes. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00637.2018
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http://dx.doi.org/10.1152/ajpheart.00637.2018DOI Listing
January 2019
4 Reads

The role of ubiquitin in cardiac ischemia-reperfusion injury.

Am J Physiol Heart Circ Physiol 2019 Jan 18. Epub 2019 Jan 18.

Anatomy, Biochemistry & Physiology, University of Hawai'i, United States.

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http://dx.doi.org/10.1152/ajpheart.00018.2019DOI Listing
January 2019
1 Read

Long term testosterone deficiency modifies myofilament and calcium handling proteins and promotes diastolic dysfunction in the aging mouse heart.

Am J Physiol Heart Circ Physiol 2019 Jan 18. Epub 2019 Jan 18.

Department of Pharmacology, Sir Charles Tupper Medical Building, Canada.

The impact of long-term gonadectomy (GDX) on cardiac contractile function was explored in the setting of aging. Male mice had a bilateral GDX or sham-operation (4 weeks) and were investigated at 16-18 months. Ventricular myocytes were field stimulated (2 Hz; 37°C). Read More

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http://dx.doi.org/10.1152/ajpheart.00471.2018DOI Listing
January 2019
1 Read

Modulatory influence of sex hormones on vascular aging.

Authors:
Kerrie L Moreau

Am J Physiol Heart Circ Physiol 2019 Mar 11;316(3):H522-H526. Epub 2019 Jan 11.

University of Colorado Anschutz Medical Campus, Aurora, Colorado.

This review summarizes a presentation given during the "Countermeasures to Cardiovascular Aging Symposium" that was part of the American Physiological Society Conference on Cardiovascular Aging: New Frontiers and Old Friends held in Westminster, CO, in August 2017. Endothelial dysfunction, a characteristic of vascular aging, is a major risk factor for age-associated cardiovascular diseases. In women, the decline in endothelial function is attenuated until menopause, whereafter the rate of decline accelerates to match that seen in men. Read More

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http://dx.doi.org/10.1152/ajpheart.00745.2017DOI Listing
March 2019
1 Read

Role of Matrix Metalloproteinases and Histone Deacetylase in Oxidative Stress-induced Degradation of the Endothelial Glycocalyx.

Am J Physiol Heart Circ Physiol 2019 Jan 11. Epub 2019 Jan 11.

Physical Therapy and Medicine, University of Illinois-Chicago, United States.

Background: Endothelial glycocalyx is crucial for normal endothelial function. It also tethers the extracellular superoxide dismutase (SOD3) which protects the endothelium against oxidative damage. The proteolytic enzymes Matrix Metalloproteinases (MMPs) are capable of disrupting endothelial cell surface proteins such as syndecans resulting in derangements of endothelial glycocalyx. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00090.2018
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http://dx.doi.org/10.1152/ajpheart.00090.2018DOI Listing
January 2019
8 Reads
3.838 Impact Factor

Placental vascular abnormalities in the mouse alters umbilical artery wave reflections.

Am J Physiol Heart Circ Physiol 2019 Jan 11. Epub 2019 Jan 11.

Hospital for Sick Children, Canada.

Current methods to detect placental vascular pathologies that monitor Doppler ultrasound changes in umbilical artery (UA) pulsatility have only moderate diagnostic utility, particularly in late gestation. In fetal mice, we recently demonstrated that reflected pressure waves propagate counter to the direction of flow in the UA, and proposed the measurement of these reflections as a means to detect abnormalities in the placental circulation. In the present study, we used this approach in combination with micro-computed tomography to investigate the relationship between altered placental vascular architecture and changes in UA wave reflection metrics. Read More

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http://dx.doi.org/10.1152/ajpheart.00733.2018DOI Listing
January 2019
1 Read

Corrigendum.

Authors:

Am J Physiol Heart Circ Physiol 2019 Jan;316(1):H255

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http://dx.doi.org/10.1152/ajpheart.zh4-2550-corr.2018DOI Listing
January 2019
1 Read

Tobacco Smoking Induces Cardiovascular Mitochondrial Oxidative Stress, Promotes Endothelial Dysfunction and Enhances Hypertension.

Am J Physiol Heart Circ Physiol 2019 Jan 4. Epub 2019 Jan 4.

Division of Clinical Pharmacology, Vanderbilt University Medical Center, United States.

Tobacco smoking is a major risk factor for cardiovascular disease and hypertension. It is associated with the oxidative stress and induces metabolic reprograming altering mitochondrial function. We hypothesized that cigarette smoke induces cardiovascular mitochondrial oxidative stress which contributes to endothelial dysfunction and hypertension. Read More

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http://dx.doi.org/10.1152/ajpheart.00595.2018DOI Listing
January 2019
2 Reads

Estimation of the baroreflex total loop gain by the power spectral analysis of continuous arterial pressure recordings.

Am J Physiol Heart Circ Physiol 2019 Jan 4. Epub 2019 Jan 4.

Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University.

Baroreflex dysfunction contributes to the pathogenesis of cardiovascular diseases. The baroreflex comprises a negative feedback loop to stabilize arterial pressure (AP); its pressure-stabilizing capacity is defined as the gain (G) of the transfer function (H) of the baroreflex total loop. However, no method exists to evaluate G in a clinical setting. Read More

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http://dx.doi.org/10.1152/ajpheart.00681.2018DOI Listing
January 2019
1 Read

Muscle Sympathetic Nerve Activity and Hemodynamic Responses to Venous Distension: Does Sex Play a Role?

Am J Physiol Heart Circ Physiol 2018 Dec 28. Epub 2018 Dec 28.

Department of Physiology and Pharmacology, Fluminense Federal University, Brazil.

Peripheral venous distension mechanically stimulates type III/IV sensory fibers in veins and evokes pressor and sympathoexcitatory reflex responses in humans. As young females have reduced venous compliance and impaired sympathetic transduction, we tested the hypothesis that pressor and sympathoexcitatory responses to venous distension may be attenuated in women compared to men. Mean arterial pressure (MAP, photoplethysmography), heart rate (HR), stroke volume (SV, Modelflow), cardiac output (CO = HR x SV), muscle sympathetic nerve activity (MSNA), femoral artery blood flow and conductance (FABF and FACT, Doppler ultrasound) were quantified in 8 males (27±4 yrs. Read More

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http://dx.doi.org/10.1152/ajpheart.00702.2018DOI Listing
December 2018
1 Read

Differentiating Compensatory Mechanisms Associated to Low Tolerance to Central Hypovolemia in Females.

Am J Physiol Heart Circ Physiol 2018 Dec 28. Epub 2018 Dec 28.

Office of the Senior Scientist, US Army Institute of Surgical Research, Fort Sam Houston, TX 78234-6315, USA, United States.

Women generally display lower tolerance to acute central hypovolemia than men. The measurement of compensatory reserve (CRM) is a novel metric that provides information about the sum total of all mechanisms that together work to compensate for relative blood volume deficit. Hemodynamic decompensation occurs with depletion of the CRM (i. Read More

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http://dx.doi.org/10.1152/ajpheart.00420.2018DOI Listing
December 2018
1 Read

Transient outward K current can strongly modulate action potential duration and initiate alternans in the human atrium.

Am J Physiol Heart Circ Physiol 2019 Mar 21;316(3):H527-H542. Epub 2018 Dec 21.

Faculties of Kinesiology and Medicine, University of Calgary , Calgary, Alberta , Canada.

Efforts to identify the mechanisms for the initiation and maintenance of human atrial fibrillation (AF) often focus on changes in specific elements of the atrial "substrate," i.e., its electrophysiological properties and/or structural components. Read More

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http://dx.doi.org/10.1152/ajpheart.00251.2018DOI Listing
March 2019
1 Read

F-FDG Cardiac PET inflammation imaging in a canine model of radiation induced cardiac disease associated with breast cancer radiotherapy.

Am J Physiol Heart Circ Physiol 2018 Dec 21. Epub 2018 Dec 21.

Medical Biophysics, Western University.

Background And Purpose: Radiotherapy for the treatment of left-sided breast cancer increases the long term risk of cardiovascular disease. The purpose of this study was to non-invasively image the progression of radiation-induced cardiac inflammation in a large animal model using a hybrid positron emission tomography and magnetic resonance imaging system.

Materials And Methods: 5 canines were imaged using F-fluorodeoxyglucose (FDG) PET to assess changes in myocardial inflammation. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00273.2018
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http://dx.doi.org/10.1152/ajpheart.00273.2018DOI Listing
December 2018
14 Reads

Effect of Melatonin on EGF- and VEGF-induced monolayer permeability of HUVECs.

Am J Physiol Heart Circ Physiol 2018 Dec 21. Epub 2018 Dec 21.

Nanjing Medical University, China.

Melatonin is a natural hormone involved in the regulation of circadian rhythm, immunity, and cardiovascular function. In this study, we focused on the mechanism of melatonin in the regulation of vascular permeability. We found that melatonin could inhibit both vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) induced monolayer permeability of human umbilical vein endothelial cells (HUVECs) and change the tyrosine phosphorylation of vascular endothelial cadherin (VE-cadherin), which was related to endothelial barrier function. Read More

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http://dx.doi.org/10.1152/ajpheart.00542.2018DOI Listing
December 2018
1 Read

HIF-1 regulation of miR-29c impairs SERCA2 expression and cardiac contractility.

Am J Physiol Heart Circ Physiol 2019 Mar 21;316(3):H554-H565. Epub 2018 Dec 21.

Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii , Honolulu, Hawaii.

The principal regulator of cellular response to low oxygen is hypoxia-inducible factor (HIF)-1, which is stabilized in several forms of heart failure. Our laboratory developed a mouse strain in which a stable form of HIF-1 can be inducibly expressed in cardiomyocytes. Strikingly, these mice show a rapid decrease in cardiac contractility and a rapid loss of SERCA2 protein, which is also seen in heart failure. Read More

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http://dx.doi.org/10.1152/ajpheart.00617.2018DOI Listing
March 2019
1 Read

Acute heat stress reduces biomarkers of endothelial activation but not macro- or microvascular dysfunction in cervical spinal cord injury.

Am J Physiol Heart Circ Physiol 2018 12 21. Epub 2018 Dec 21.

School of Health and Exercise Sciences, University of British Columbia - Okanagan.

Cardiovascular diseases (CVD) are highly prevalent in spinal cord injury (SCI) and peripheral vascular dysfunction might be a contributing factor. Recent evidence demonstrates that exposure to heat stress can improve vascular function and reduce the risk of CVD in uninjured populations. We therefore aimed to examine the extent of vascular dysfunction in spinal cord injury (SCI) and the acute effects of passive heating. Read More

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http://dx.doi.org/10.1152/ajpheart.00693.2018DOI Listing
December 2018
2 Reads

Novel role of the ER/SR Ca sensor, STIM1, in regulation of cardiac metabolism.

Am J Physiol Heart Circ Physiol 2018 Dec 21. Epub 2018 Dec 21.

Pathology, University of Alabama at Birmingham, United States.

The ER/SR Ca sensor, stromal interaction molecule 1 (STIM1), a key mediator of store-operated calcium entry, is expressed in cardiomyocytes and has been implicated in regulating multiple cardiac processes, including hypertrophic signaling. Interestingly, cardiomyocyte-restricted deletion of STIM1 (STIM1-KO) results in age-dependent ER stress, altered mitochondrial morphology, and dilated cardiomyopathy in mice. Here, we tested the hypothesis that STIM1 deficiency may also impact cardiac metabolism. Read More

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http://dx.doi.org/10.1152/ajpheart.00544.2018DOI Listing
December 2018
3 Reads

Cardioprotection via the skin: nociceptor-induced conditioning against cardiac MI in the NIC of time.

Am J Physiol Heart Circ Physiol 2019 Mar 21;316(3):H543-H553. Epub 2018 Dec 21.

Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Mawood, Illinois.

Timely reperfusion is still the most effective approach to limit infarct size in humans. Yet, despite advances in care and reduction in door-to-balloon times, nearly 25% of patients develop heart failure postmyocardial infarction, with its attendant morbidity and mortality. We previously showed that cardioprotection results from a skin incision through the umbilicus in a murine model of myocardial infarction. Read More

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http://dx.doi.org/10.1152/ajpheart.00094.2018DOI Listing
March 2019
7 Reads
3.838 Impact Factor

Moving Galectin-3 Closer to the Goal Line.

Am J Physiol Heart Circ Physiol 2018 Dec 21. Epub 2018 Dec 21.

Cardiology, University Medical Center Groningen, Netherlands.

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http://dx.doi.org/10.1152/ajpheart.00761.2018DOI Listing
December 2018
1 Read

Possible mechanism of late systolic mitral valve prolapse: systolic superior shift of leaflets secondary to annular dilatation that tracts papillary muscle.

Am J Physiol Heart Circ Physiol 2018 Dec 21. Epub 2018 Dec 21.

Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan.

Progressive superior shift of mitral valve (MV) during systole is associated with abnormal papillary muscles (PMs) superior shift in late systolic MV prolapse (MVP). Causal relation on these superior shifts remains unclarified. We hypothesized that MV superior shift is related to augmented MV superiorly pushing force by systolic left ventricular pressure due to MV annular dilatation, which can be corrected by surgical MV plasty, leading to postoperative disappearance of these superior shifts. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00618.2018
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http://dx.doi.org/10.1152/ajpheart.00618.2018DOI Listing
December 2018
4 Reads

Right coronary artery ligation in mice: A novel method to investigate right ventricular dysfunction and biventricular interaction.

Am J Physiol Heart Circ Physiol 2018 Dec 21. Epub 2018 Dec 21.

Montpellier University, Inserm U1046 Physiologie et Médecine Expérimentale, France.

Right ventricular (RV) dysfunction can lead to complications following acute inferior myocardial infarction (MI). However, it is unclear how RV failure after MI contributes to left-sided dysfunction is unclear. The aim of this study was to investigate the consequences of right coronary artery (RCA) ligation in mice. Read More

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http://dx.doi.org/10.1152/ajpheart.00573.2018DOI Listing
December 2018
4 Reads

Role of the Cytoskeleton in the Development of a Hypofibrotic Cardiac Fibroblast Phenotype in Volume Overload Heart Failure.

Am J Physiol Heart Circ Physiol 2018 Dec 21. Epub 2018 Dec 21.

Biomedical Engineering, The Ohio State University, United States.

Hemodynamic load regulates cardiac remodeling. In contrast to pressure overload (increased afterload), hearts subjected to volume overload (VO, preload) undergo a distinct pattern of eccentric remodeling, chamber dilation and decreased extracellular matrix content. Critical pro-fibrotic roles of cardiac fibroblasts (CF) in post-infarct remodeling and in response to pressure overload is well-established. Read More

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http://dx.doi.org/10.1152/ajpheart.00095.2018DOI Listing
December 2018
1 Read