Inhibition of Ubiquitin-activating Enzyme Protects against Organ Injury after Intestinal Ischemia-Reperfusion.
Am J Physiol Gastrointest Liver Physiol 2018 May 17. Epub 2018 May 17.
Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, United States.
Intestinal ischemia-reperfusion (I/R) occurs in various clinical settings, such as transplantation, acute mesenteric arterial occlusion, trauma and shock. I/R injury causes severe systemic inflammation, leading to multiple organ dysfunction associated with high mortality. The ubiquitin proteasome pathway has been indicated in the regulation of inflammation, particularly through NF-κB signaling pathway. Read More