Low protein diet-induced hyperphagia and adiposity are modulated through interactions involving thermoregulation, motor activity, and protein quality in mice.
- Anne Blais,
- Catherine Chaumontet,
- Dalila Azzout-Marniche,
- Julien Piedcoq,
- Gilles Fromentin,
- Claire Gaudichon,
- Daniel Tomé,
- Patrick C Even
Am J Physiol Endocrinol Metab 2017 Nov 14:ajpendo.00318.2017. Epub 2017 Nov 14.
UMR PNCA, AgroParisTech, INRA, Université Paris-Saclay
Low-protein (LP) containing diets can induce overeating in rodents and possibly in humans in an effort to meet protein requirement but the consequences on energy expenditure (EE) are unclear. The present study evaluated the changes induced by reducing dietary protein from 20% to 6%, using either soy protein or casein, on energy intake, body composition and EE in mice housed at 22°C or at 30°C (thermal-neutrality). LP feeding increased energy intake and adiposity, more in soy fed than in casein fed mice, but also increased EE thus limiting fat accumulation. Read More