4,625 results match your criteria American Journal of Perinatology[Journal]


Resident Operative Vaginal Delivery Volume after Educational Curriculum Implementation.

Am J Perinatol 2020 May 26. Epub 2020 May 26.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, The University of Alabama at Birmingham, Birmingham, Alabama.

Objective:  The percentage of operative vaginal deliveries (OVDs) in the United States has sharply declined. In May 2016, our institution's obstetrics and gynecology (OB/GYN) residency program implemented a twice-yearly OVD curriculum consisting of didactics and simulation. We sought to evaluate the impact of this curriculum. Read More

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http://dx.doi.org/10.1055/s-0040-1710543DOI Listing

Validation of Postpartum Hemorrhage Admission Risk Factor Stratification in a Large Obstetrics Population.

Am J Perinatol 2020 May 26. Epub 2020 May 26.

Division of Research, Kaiser Permanente Northern California, Oakland, California.

Objective:  This study aimed to evaluate the performance of the California Maternal Quality Care Collaborative (CMQCC) admission risk criteria for stratifying postpartum hemorrhage risk in a large obstetrics population.

Study Design:  Using detailed electronic health record data, we classified 261,964 delivery hospitalizations from Kaiser Permanente Northern California hospitals between 2010 and 2017 into high-, medium-, and low-risk groups based on CMQCC criteria. We used logistic regression to assess associations between CMQCC risk groups and postpartum hemorrhage using two different postpartum hemorrhage definitions, standard postpartum hemorrhage (blood loss ≥1,000 mL) and severe postpartum hemorrhage (based on transfusion, laboratory, and blood loss data). Read More

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http://dx.doi.org/10.1055/s-0040-1712166DOI Listing

The Postpartum Hemorrhage Patient Safety Bundle Implementation at a Single Institution: Successes, Failures, and Lessons Learned.

Am J Perinatol 2020 May 26. Epub 2020 May 26.

Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

Objective:  In 2015, a multidisciplinary consensus bundle of recommendations for the anticipation and management of postpartum hemorrhage was published. Our goal was to evaluate the successes and failures of our institutional bundle implementation process.

Study Design:  An interdisciplinary committee was created to facilitate bundle implementation. Read More

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http://dx.doi.org/10.1055/s-0040-1712452DOI Listing

Bevacizumab for Retinopathy of Prematurity: 2-Year Neurodevelopmental Follow-up.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Division of Neonatology, Department of Pediatrics, University of South Alabama, Mobile, Alabama.

Objective:  This study aimed to determine whether infants who were treated with intravitreal bevacizumab (IVB) for retinopathy of prematurity (ROP) were at higher risk of death or neurodevelopmental impairment (NDI) when compared with infants who were not treated with IVB (Laser only).

Study Design:  This retrospective study included 146 infants born from 2009 through 2016 with a birth weight (BW) <1,000 g, gestational age <27 weeks, and required ROP therapy. Death and NDI rates were assessed at 18 to 24 months' corrected age. Read More

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http://dx.doi.org/10.1055/s-0040-1710556DOI Listing

Ongoing Supplementation of Probiotics to Cesarean-Born Neonates during the First Month of Life may Impact the Gut Microbial.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Department of Neonatal Diagnosis and Treatment Center, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Objective:  The delivery mode is considered to be a significant influencing factor in the early gut microbiota composition, which is associated with the long-term health of the host. In this study, we tried to explore the effects of probiotics on the intestinal microbiota of C-section neonates.

Study Design:  Twenty-six Chinese neonates were enrolled in this study. Read More

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http://dx.doi.org/10.1055/s-0040-1710559DOI Listing

Is Group B Streptococcus Colonization Associated with Maternal Peripartum Infection in an Era of Routine Prophylaxis?

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina.

Objective:  This study aimed to assess whether colonization with group B streptococcus (GBS) is associated with maternal peripartum infection in an era of routine prophylaxis.

Study Design:  This study presented a secondary analysis of women delivering ≥37 weeks who underwent a trial of labor from the U.S. Read More

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http://dx.doi.org/10.1055/s-0040-1709666DOI Listing

Evaluation of the Prognostic Value of the sFlt-1/PlGF Ratio in Early-Onset Preeclampsia.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Department of Obstetrics and Gynecology, Paule de Viguier Maternity, CHU Toulouse, Toulouse, France.

Objective:  Increased expression of soluble fms-like tyrosine kinase 1 (sFlt-1), associated with a decrease in placental growth factor (PlGF), plays a key role in the pathogenesis of preeclampsia (PE). We evaluated the prognostic value of the sFlt-1/PlGF ratio for the onset of adverse maternofetal outcomes (AMFO) in case of early-onset PE with attempted expectant management.

Study Design:  From October 2016 through November 2018, all singleton pregnancies complicated by early-onset PE (before 34 weeks of gestation) were included in a cohort study. Read More

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http://dx.doi.org/10.1055/s-0040-1709696DOI Listing

The Association between Shirodkar Cerclage and Preterm Premature Rupture of Membranes in Singleton Pregnancies.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Medical Education, Icahn School of Medicine at Mount Sinai, New York, New York.

Objective:  The aim of this study was to estimate if preterm premature rupture of membranes in women with cerclage is due to the cerclage itself or rather the underlying risk factors for preterm birth in this population.

Study Design:  This was a retrospective cohort study of singleton pregnancies who underwent Shirodkar cerclage by a single maternal-fetal medicine practice between 2005 and 2019. The control group was an equal number of randomly selected women with a singleton gestation who had a prior preterm birth and were treated with 17-OH-progesterone but no cerclage. Read More

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http://dx.doi.org/10.1055/s-0040-1710009DOI Listing

Mucins and Tight Junctions are Severely Altered in Necrotizing Enterocolitis Neonates.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Department of Neonatology, People's Hospital of Shenzhen, 2nd Clinical Medical College of Jinan University, Shenzhen, People's Republic of China.

Objective:  This study investigates the expression levels of mucin 1 (MUC1), MUC2, occludin, and zonula occludens-1 (ZO-1) in necrotizing enterocolitis (NEC).

Study Design:  Intestinal specimens of surgical patients suffering from NEC (the NEC group) and intestinal specimens of patients with congenital intestinal atresia (the control group) were collected. Immunohistochemical changes in MUC1, MUC2, occludin, and ZO-1 were compared between the two groups. Read More

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http://dx.doi.org/10.1055/s-0040-1710558DOI Listing

Antepartum Hemorrhage and Outcome of Very Low Birth Weight, Very Preterm Infants: A Population-Based Study.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Women and Children's Health Research Unit, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.

Objective:  We aimed to determine the independent effect of maternal antepartum hemorrhage (APH) on mortality and major neonatal morbidities among very low birth weight (VLBW), very preterm infants.

Study Design:  A population-based cohort study of VLBW singleton infants born at 24 to 31 weeks of gestation between 1995 and 2016 was performed. Infants born with the following pregnancy associated complications were excluded: maternal hypertensive disorders, prolonged rupture of membranes, amnionitis, maternal diabetes, and small for gestational age. Read More

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http://dx.doi.org/10.1055/s-0040-1710353DOI Listing

ACC-AHA Diagnostic Criteria for Hypertension in Pregnancy Identifies Patients at Intermediate Risk of Adverse Outcomes.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Objective:  The aim of the study is to compare maternal and neonatal outcomes among patients who are normotensive, hypertensive by Stage I American College of Cardiology-American Heart Association (ACC-AHA) criteria, and hypertensive by American College of Obstetricians and Gynecologists (ACOG) criteria.

Study Design:  Secondary analysis of a prospective first trimester cohort study between 2007 and 2010 at three institutions in Baltimore, MD, was conducted. Blood pressure at 11 to 14 weeks' gestation was classified as (1) normotensive (systolic blood pressure [SBP] <130 mm Hg and diastolic blood pressure [DBP] <80 mm Hg); (2) hypertensive by Stage I ACC-AHA criteria (SBP 130-139 mm Hg or DBP 80-89 mm Hg); or (3) hypertensive by ACOG criteria (SBP ≥140 mm Hg or DBP ≥90 mm Hg). Read More

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http://dx.doi.org/10.1055/s-0040-1709465DOI Listing

Interleukin-6 as a Biomarker of Early-Onset Neonatal Sepsis.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Programa de Medicina, Facultad de Salud, Universidad Surcolombiana, Neiva, Huila, Colombia.

Objective:  The aim of this study is to determine the utility of C reactive protein (CRP) and interleukin (IL)-6 in the diagnosis of neonatal sepsis (NS) in a neonatal intensive care unit (NICU) in the south of Colombia.

Study Design:  A nonmatched case-control study was conducted. Convenience sampling was performed. Read More

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http://dx.doi.org/10.1055/s-0040-1710010DOI Listing

Use of the RAM Cannula with Early Bubble Continuous Positive Airway Pressure Requires Higher Pressures: Clinical and In vitro Evaluations.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Saint Louis University School of Medicine, St. Louis, Missouri.

Objective:  Early bubble continuous positive airway pressure (bCPAP) in the delivery room (DR) reduces early intubation, mechanical ventilation, and bronchopulmonary dysplasia. The RAM cannula, adopted for ease of patient care, is a high resistance nasal interface that, when used with bCPAP, only transmits a portion of set pressures and attenuates the bubble effects. This study aimed to review early bCPAP pressures and bCPAP failure with the RAM cannula interface over a 6-year period. Read More

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http://dx.doi.org/10.1055/s-0040-1710557DOI Listing

Early Gut Microbiota Changes in Preterm Infants with Bronchopulmonary Dysplasia: A Pilot Case-Control Study.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.

Objective:  Bronchopulmonary dysplasia (BPD) is a complex chronic lung disease that primarily affects premature or critically ill infants. This pilot study investigated early changes in gut microbiota composition in BPD patients and explored the potential risk factors associated with these changes.

Study Design:  Preterm infants admitted to our neonatal intensive care unit with a gestational age of 26 to 32 weeks were prospectively surveyed and eligible for stool collection on days 7 and 28 of postnatal age between February 2016 and June 2017. Read More

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http://dx.doi.org/10.1055/s-0040-1710554DOI Listing

Platelets and Immature Neutrophils in Preterm Infants with Feeding Intolerance.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida.

Objective:  Feeding intolerance (FI) is a common presentation of necrotizing enterocolitis (NEC) and sepsis. NEC and sepsis are associated with hematological changes, but these changes alone are not reliable biomarkers for early diagnosis. This study examined whether the combination of hematological indices and FI can be used as an early diagnostic tool for NEC or sepsis. Read More

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http://dx.doi.org/10.1055/s-0040-1710555DOI Listing
May 2020
1.597 Impact Factor

Hemorrhage Risk Assessment on Admission: Utility for Prediction of Maternal Morbidity.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Department of Pediatrics and Pathology, The George Washington University School of Medicine & Health Sciences, Washington, District of Columbia.

Objective:  Hemorrhage is a major cause of maternal morbidity and mortality prompting creation of innovative risk assessment tools to identify patients at highest risk. We aimed to investigate the association of hemorrhage risk assessment with maternal morbidity and to evaluate maternal outcomes after implementation of the risk assessment across hospital sites.

Study Design:  We conducted a retrospective cohort analysis of a multicenter database including women admitted to labor and delivery from January 2015 to June 2018. Read More

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http://dx.doi.org/10.1055/s-0040-1710501DOI Listing

N95 Filtering Facepiece Respirator Use during Pregnancy: A Systematic Review.

Am J Perinatol 2020 May 21. Epub 2020 May 21.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of South Florida, Morsani College of Medicine, Tampa, Florida.

Objective:  This study was aimed to systematically review the use of filtering facepiece respirators, such asN95 masks, during pregnancy.

Study Design:  A comprehensive search for primary literature using Medline, Embase, Scopus, Web of Science, and ClinicalTrials.gov was conducted from inception until April 2020 to find articles reporting outcomes of pregnant women using filtering facepiece respirator (FFR). Read More

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http://dx.doi.org/10.1055/s-0040-1712475DOI Listing

A Framework for Coordination between Obstetric and Pediatric Providers in Public Health Emergencies: Lessons Learned from the Zika Outbreak in the United States, 2015 to 2017.

Am J Perinatol 2020 May 21. Epub 2020 May 21.

Department of Pediatrics, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida.

Emergency response to emerging threats with the potential for vertical transmission, such as the 2015 to 2017 response to Zika virus, presents unique clinical challenges that underscore the need for better communication and care coordination between obstetric and pediatric providers to promote optimal health for women and infants. Published guidelines for routine maternal-infant care during the perinatal period, and models for transitions of care in various health care settings are available, but no broad framework has addressed coordinated multidisciplinary care of the maternal-infant dyad during emergency response. We present a novel framework and strategies to improve care coordination and communication during an emergency response. Read More

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http://dx.doi.org/10.1055/s-0040-1712104DOI Listing

COVID-19 in Pregnant Women: Case Series from One Large New York City Obstetrical Practice.

Am J Perinatol 2020 May 21. Epub 2020 May 21.

Maternal Fetal Medicine Associates, PLLC, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York.

Objective:  This study aimed to report a case series of pregnant women in New York City with confirmed or presumed coronavirus disease (COVID-19) infection.

Study Design:  Beginning March 22, 2020, all pregnant women from one large obstetrical practice in New York City were contacted regularly to inquire about symptoms of COVID-19 (fever, cough, shortness of breath, malaise, anosmia), or sick contacts. A running log was kept of these patients, as well as all patients who underwent COVID-19 testing. Read More

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http://dx.doi.org/10.1055/s-0040-1712529DOI Listing

Exclusion of Pregnant Women from Clinical Trials during the Coronavirus Disease 2019 Pandemic: A Review of International Registries.

Am J Perinatol 2020 May 19. Epub 2020 May 19.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, Ohio.

Objective:  Pregnant women have been historically excluded from clinical trials for nonobstetric conditions, even during prior epidemics. The objective of this review is to describe the current state of research for pregnant women during the coronavirus disease 2019 (COVID-19) pandemic.

Study Design:  We conducted a search of international trial registries for trials relating to the novel coronavirus. Read More

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http://dx.doi.org/10.1055/s-0040-1712103DOI Listing

The Relationship between Status at Presentation and Outcomes among Pregnant Women with COVID-19.

Am J Perinatol 2020 May 19. Epub 2020 May 19.

Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New York.

Objective:  This study was aimed to compare maternal and pregnancy outcomes of symptomatic and asymptomatic pregnant women with novel coronavirus disease 2019 (COVID-19).

Study Design:  This is a retrospective cohort study of pregnant women with COVID-19. Pregnant women were divided into two groups based on status at admission, symptomatic or asymptomatic. Read More

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http://dx.doi.org/10.1055/s-0040-1712164DOI Listing

Community Obstetrical Units Less Likely than Academic Units to Have Universal COVID-19 Testing.

Am J Perinatol 2020 May 19. Epub 2020 May 19.

Department of Obstetrics and Gynecology, Maternal and Child Health Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1055/s-0040-1712454DOI Listing

Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review.

Authors:
Ziyi Yang Yi Liu

Am J Perinatol 2020 May 13. Epub 2020 May 13.

Department of Obstetrics, Chengdu Jinjiang Maternity and Child Health Hospital, Chengdu, China.

Objective:  The aim of this study is to summarize currently available evidence on vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Study Design:  A systematic review was conducted following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis Statement.

Results:  A total of 22 studies comprising 83 neonates born to mothers diagnosed with coronavirus disease 2019 were included in the present systematic review. Read More

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http://dx.doi.org/10.1055/s-0040-1712161DOI Listing

Laboratory Abnormalities in Pregnant Women with Novel Coronavirus Disease 2019.

Am J Perinatol 2020 May 12. Epub 2020 May 12.

Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou, China.

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http://dx.doi.org/10.1055/s-0040-1712181DOI Listing

Telehealth for High-Risk Pregnancies in the Setting of the COVID-19 Pandemic.

Am J Perinatol 2020 May 12. Epub 2020 May 12.

Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.

As New York City became an international epicenter of the novel coronavirus disease 2020 (COVID-19) pandemic, telehealth was rapidly integrated into prenatal care at Columbia University Irving Medical Center, an academic hospital system in Manhattan. Goals of implementation were to consolidate in-person prenatal screening, surveillance, and examinations into fewer in-person visits while maintaining patient access to ongoing antenatal care and subspecialty consultations via telehealth virtual visits. The rationale for this change was to minimize patient travel and thus risk for COVID-19 exposure. Read More

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http://dx.doi.org/10.1055/s-0040-1712121DOI Listing

A Proposed Plan for Prenatal Care to Minimize Risks of COVID-19 to Patients and Providers: Focus on Hypertensive Disorders of Pregnancy.

Am J Perinatol 2020 May 12. Epub 2020 May 12.

Department of Obstetrics, Gynecology, Reproductive Sciences, University of Texas-Houston, Houston, Texas.

Hypertensive disorders are the most common medical complications of pregnancy and a major cause of maternal and perinatal morbidity and death. The detection of elevated blood pressure during pregnancy is one of the cardinal aspects of optimal antenatal care. With the outbreak of novel coronavirus disease 2019 (COVID-19) and the risk for person-to-person spread of the virus, there is a desire to minimize unnecessary visits to health care facilities. Read More

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http://dx.doi.org/10.1055/s-0040-1710538DOI Listing

Randomized Trials of Retosiban Versus Placebo or Atosiban in Spontaneous Preterm Labor.

Am J Perinatol 2020 May 7. Epub 2020 May 7.

Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Objective:  The aim of this study is to assess the efficacy and safety of retosiban in spontaneous preterm labor (sPTL).

Study Design:  Two multicenter, randomized, and double-blind trials compared retosiban with placebo and retosiban with atosiban in women with a singleton pregnancy and intact membranes in sPTL at 24 to 33 weeks' gestation. Coprimary endpoints in the placebo-controlled trial were time to delivery (TTD) or treatment failure (whichever occurred first) and neonatal composite morbidity and mortality. Read More

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http://dx.doi.org/10.1055/s-0040-1710034DOI Listing

COVID-19 in Newborns and Infants-Low Risk of Severe Disease: Silver Lining or Dark Cloud?

Am J Perinatol 2020 May 7. Epub 2020 May 7.

Department of Pediatrics, University of California, Davis, California.

One hundred years after the 1918 influenza pandemic, we now face another pandemic with the severe acute respiratory syndrome-novel coronavirus-2 (SARS-CoV-2). There is considerable variability in the incidence of infection and severe disease following exposure to SARS-CoV-2. Data from China and the United States suggest a low prevalence of neonates, infants, and children, with those affected not suffering from severe disease. Read More

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http://dx.doi.org/10.1055/s-0040-1710512DOI Listing

Caring for Pregnant Patients with COVID-19: Practical Tips Getting from Policy to Practice.

Am J Perinatol 2020 May 7. Epub 2020 May 7.

Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New York.

Novel coronavirus disease 2019 (COVID-19) is a pandemic with most American cases in New York. As an institution residing in a high-prevalence zip code, with over 8,000 births annually, we have cared for over 80 COVID-19-infected pregnant women, and have encountered many challenges in applying new national standards for care. In this article, we review how to change outpatient and inpatient practices, develop, and disseminate new hospital protocols, and we highlight the psychosocial challenges for pregnant patients and their providers. Read More

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http://dx.doi.org/10.1055/s-0040-1710539DOI Listing

Does Duration Off Respiratory Support Prior to Discharge from NICU Predict Hospital Readmission among Extremely Low Gestational Age Neonates?

Am J Perinatol 2020 May 5. Epub 2020 May 5.

Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.

Objective:  Our objective was to determine if the duration off respiratory support prior to discharge home from the neonatal intensive care unit (NICU) would impact hospital readmission rates among extremely low gestational age neonates (ELGAN).

Study Design:  In this retrospective chart review, we examined readmission rates for ELGAN admitted to the Montefiore-Weiler NICU between 2013 and 2015.

Results:  Of 140 infants born at <29 weeks' gestational age, 30 (21%) of these infants were subsequently readmitted within 90 days, primarily for respiratory complaints. Read More

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http://dx.doi.org/10.1055/s-0040-1710011DOI Listing

Hospital Safety-Net Burden and Risk for Readmissions and Severe Maternal Morbidity.

Am J Perinatol 2020 May 5. Epub 2020 May 5.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York.

Objective:  This study aimed to analyze whether hospital safety-net burden status is associated with increased risk for severe maternal morbidity (SMM) and postpartum readmissions.

Study Design:  The 2010 to 2014 Nationwide Readmissions Database was utilized for this retrospective cohort study. Hospitals were categorized as high-burden hospitals (25% of hospitals with the highest safety-net burden), medium-burden hospitals (50% of hospitals with intermediate safety-net burden), and low-burden hospitals (25% of hospitals with the lowest safety-net burden) based on the proportions of Medicaid or uninsured patients. Read More

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http://dx.doi.org/10.1055/s-0040-1710544DOI Listing

Maternal Health after Stillbirth: Postpartum Hospital Readmission in California.

Am J Perinatol 2020 May 4. Epub 2020 May 4.

Department of Pediatrics and Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California.

Objective:  The aim of this study is to assess whether the risk of postpartum readmission within 6 weeks of giving birth differs for women who had stillbirths compared with live births.

Study Design:  Using data from the Office of Statewide Health Planning and Development in California, we performed a population-based cohort study of 7,398,640 births between 1999 and 2011. We identified diagnoses and procedures associated with the first postpartum hospital readmission that occurred within 6 weeks after giving birth. Read More

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http://dx.doi.org/10.1055/s-0040-1708803DOI Listing

Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2.

Am J Perinatol 2020 May 2. Epub 2020 May 2.

Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Objective:  To date, no information on late-onset infection in newborns to mother with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contracted in pregnancy are available. This study aimed to evaluate postdischarge SARS-CoV-2 status of newborns to mothers with COVID-19 in pregnancy that, at birth, were negative to SARS-CoV-2.

Study Design:  This is an observational study of neonates born to mothers with coronavirus disease 2019 (COVID-19). Read More

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http://dx.doi.org/10.1055/s-0040-1710541DOI Listing

COVID-19 and Neonatal Respiratory Care: Current Evidence and Practical Approach.

Am J Perinatol 2020 May 2. Epub 2020 May 2.

Neonatal Division, Department of Pediatrics, McGill University Health Center, Montreal, Quebec, Canada.

The novel coronavirus disease 2019 (COVID-19) pandemic has urged the development and implementation of guidelines and protocols on diagnosis, management, infection control strategies, and discharge planning. However, very little is currently known about neonatal COVID-19 and severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infections. Thus, many questions arise with regard to respiratory care after birth, necessary protection to health care workers (HCW) in the delivery room and neonatal intensive care unit (NICU), and safety of bag and mask ventilation, noninvasive respiratory support, deep suctioning, endotracheal intubation, and mechanical ventilation. Read More

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http://dx.doi.org/10.1055/s-0040-1710522DOI Listing

Resveratrol Relieves Hyperoxia-Induced Brain Injury in Neonatal Rats by Activating Sirt1.

Am J Perinatol 2020 May 1. Epub 2020 May 1.

Department of Newborn Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Objective:  Neonatal rats with hyperoxia-induced brain injury were treated with resveratrol to investigate its protective effects through analyzing changes in reactive oxygen species (ROS), Sirt1, p53, and acetylated p53 levels.

Study Design:  Neonatal rats were randomly divided into hyperoxia and resveratrol intervened groups. Rats in both groups were placed in a hyperoxia chamber for 7 days to induce hyperoxia-induced brain injury. Read More

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http://dx.doi.org/10.1055/s-0040-1710352DOI Listing

Predictors of Early Preterm Birth Despite Vaginal Progesterone Therapy in Singletons with Short Cervix.

Am J Perinatol 2020 Apr 28. Epub 2020 Apr 28.

Division of Maternal Fetal Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.

Objective:  Identify the incidence of and risk factors for early preterm birth (PTB) (delivery <34 weeks) in women without prior PTB and current short cervix (≤20 mm) prescribed vaginal progesterone.

Study Design:  Retrospective cohort study of singletons without prior PTB diagnosed with short cervix (≤20 mm) between 18 and 23 weeks. Women who accepted vaginal progesterone and had delivery outcomes available were included. Read More

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http://dx.doi.org/10.1055/s-0040-1710008DOI Listing

Structured Neonatal Point-of-Care Ultrasound Training Program.

Am J Perinatol 2020 Apr 28. Epub 2020 Apr 28.

Division of Radiology, Department of Pediatrics, Cohen Children's Medical Center, New Hyde Park, New York.

Objective:  Point-of-care ultrasound (POC US) has been increasingly used by intensive care physicians. Growing use of POC US necessitates defining distinct clinical indications for its application, as well as structured POC US training programs. Homogeneous approach to POC US education combined with rigorous quality assurance should further enable POC US to become standard-of-care clinical tool. Read More

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http://dx.doi.org/10.1055/s-0040-1709667DOI Listing

General Guidelines in the Management of an Obstetrical Patient on the Labor and Delivery Unit during the COVID-19 Pandemic.

Am J Perinatol 2020 Apr 28. Epub 2020 Apr 28.

Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.

Novel coronavirus disease 2019 (COVID-19) is a respiratory tract infection that was first identified in China. Since its emergence in December 2019, the virus has rapidly spread, transcending geographic barriers. The World Health Organization and the Centers for Disease Control and Prevention have declared COVID-19 as a public health crisis. Read More

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http://dx.doi.org/10.1055/s-0040-1710308DOI Listing

Adverse Outcomes among Low-Risk Pregnancies at 39 to 41 Weeks: Stratified by Birth Weight Percentile.

Am J Perinatol 2020 Apr 27. Epub 2020 Apr 27.

Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.

Objective:  This study aimed to assess the risk of adverse outcomes among low-risk pregnancies at 39 to 41 weeks, stratified by birth weight percentile.

Study Design:  This retrospective cohort study utilized the U.S. Read More

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http://dx.doi.org/10.1055/s-0040-1709673DOI Listing
April 2020
1.597 Impact Factor

Consistency between Impedance Technique and Echocardiogram Hemodynamic Measurements in Neonates.

Am J Perinatol 2020 Apr 25. Epub 2020 Apr 25.

School of Public Health, Guangdong Medical University, China.

Objective:  The aim of this study was to validate impedance technique (IT) by investigating the agreement in cardiac output measurements performed by IT and echocardiography (ECHO).

Study Design:  This is a prospective observational study, including a total of 30 neonates who underwent hemodynamic measurements by IT and ECHO. To determine the agreement between both methods, we performed IT to measure stroke volume (SV-IT) and cardiac output (CO-IT) immediately before or after ECHO to measure SV (SV-ECHO) and CO (CO-ECHO). Read More

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http://dx.doi.org/10.1055/s-0040-1710030DOI Listing

Successful Treatment of Preterm Labor in Association with Acute COVID-19 Infection.

Am J Perinatol 2020 Apr 24. Epub 2020 Apr 24.

Division of Infectious Diseases, Department of Internal Medicine, Lexington Medical Center, West Columbia, South Carolina.

Novel coronavirus disease 2019 (COVID-19) infection occurring during pregnancy is associated with an increased risk of preterm delivery. This case report describes successful treatment of preterm labor during acute COVID-19 infection. Standard treatment for preterm labor may allow patients with acute COVID-19 infection to recover without the need for preterm delivery. Read More

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http://dx.doi.org/10.1055/s-0040-1709993DOI Listing

Specialized Pediatric Palliative Care in Neonates with Life-Limiting Illness: A Systematic Review.

Am J Perinatol 2020 Apr 24. Epub 2020 Apr 24.

Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada.

Objective:  The aim of this study is to assess the impact of specialized pediatric palliative care (PPC) on neonates with life-limiting conditions compared to standard care.

Study Design:  MEDLINE, PsycINFO, Cochrane Central Register of Controlled Trials, Web of Science, CINAHL, Scopus, and Embase databases were searched from January 2000 to September 2018. Randomized clinical trials, experimental or observational studies, and secondary administrative database analyses published in English, Spanish, French, and German were included. Read More

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http://dx.doi.org/10.1055/s-0040-1710031DOI Listing

The Maternal Impact, Health Burden, and Postpartum Sequela in Triplet Pregnancies: A Retrospective Cohort.

Am J Perinatol 2020 Apr 24. Epub 2020 Apr 24.

Department of Obstetrics and Gynecology, TriHealth, Cincinnati, Ohio.

Objective:  The aim of the study is to describe the maternal health burden and perinatal outcomes in triplet pregnancies, and identify the maternal and pregnancy indicators associated with increased perinatal morbidity and mortality.

Study Design:  This is a retrospective cohort study of triplet pregnancies from 2007 to 2014. Maternal data were manually collected and assessed until 6 weeks postpartum, and neonatal data were assessed until hospital discharge or death. Read More

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http://dx.doi.org/10.1055/s-0040-1709489DOI Listing

Vitamin D Status May Help Explain Maternal Race and Ethnic Factors in Primary Cesarean Section Delivery.

Authors:
William B Grant

Am J Perinatol 2020 Apr 24. Epub 2020 Apr 24.

Sunlight, Nutrition, and Health Research Center, San Francisco, California.

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http://dx.doi.org/10.1055/s-0040-1709494DOI Listing
April 2020
1.597 Impact Factor

Near-Infrared Spectroscopy: A Tool for Diagnosing Necrotizing Enterocolitis at Onset of Symptoms in Preterm Neonates with Acute Gastrointestinal Symptoms?

Am J Perinatol 2020 Apr 23. Epub 2020 Apr 23.

Neonatal Intensive Care Unit, Arnaud de Villeneuve Hospital, Montpellier University Hospital Center, Montpellier, France.

Objective:  In premature neonates, bloody stools and/or abdominal distension with feeding intolerance may be inaugural signs of necrotizing enterocolitis (NEC). We assessed the ability of near-infrared spectroscopy (NIRS) to distinguish those neonates with NEC soon after the occurrence of these symptoms.

Study Design:  We prospectively collected NIRS measurements of abdominal and cerebral regional tissue oxygen saturation (r-SO), with values masked by an opaque cover. Read More

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http://dx.doi.org/10.1055/s-0040-1710033DOI Listing

Hepatitis C Virus in Pregnancy: A Systematic Review of the Literature.

Am J Perinatol 2020 Apr 22. Epub 2020 Apr 22.

Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, Florida.

Objective:  The aim of this study was to systematically review the literature to summarize recent demographic characteristics of hepatitis C virus (HCV) infection during pregnancy and the efficacy of risk-based versus universal screening.

Study Design:  PubMed, EMBASE, and Cochrane Library were searched to identify relevant studies. Studies that recognized hepatitis C as a primary or secondary outcome, with pregnant women as the population and written in English, were included. Read More

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http://dx.doi.org/10.1055/s-0040-1709672DOI Listing

Mild Neonatal Acidemia is Associated with Neonatal Morbidity at Term.

Am J Perinatol 2020 Apr 22. Epub 2020 Apr 22.

Department of Women's Health, The University of Texas at Austin, Dell Medical School, Austin, Texas.

Objective:  The aim of this study is to determine the association between mild acidemia (umbilical artery [UA] pH: 7.11-7.19) and neonatal morbidity in neonates at term. Read More

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http://dx.doi.org/10.1055/s-0040-1708800DOI Listing

Severe COVID-19 during Pregnancy and Possible Vertical Transmission.

Am J Perinatol 2020 Apr 18. Epub 2020 Apr 18.

Division of Maternal Fetal Medicine, British American Hospital, Lima, Peru.

There are few cases of pregnant women with novel corona virus 2019 (COVID-19) in the literature, most of them with a mild illness course. There is limited evidence about in utero infection and early positive neonatal testing. A 41-year-old G3P2 with a history of previous cesarean deliveries and diabetes mellitus presented with a 4-day history of malaise, low-grade fever, and progressive shortness of breath. Read More

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http://dx.doi.org/10.1055/s-0040-1710050DOI Listing

Considerations for Obstetric Care during the COVID-19 Pandemic.

Am J Perinatol 2020 Apr 17. Epub 2020 Apr 17.

Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.

The novel coronavirus disease 2019 (COVID-19) is a growing pandemic that is impacting daily life across the globe. Though disease is often mild, in high-risk populations, severe disease often leads to intubation, intensive care admission (ICU) admission, and in many cases death. The implications for pregnancy remain largely unknown. Read More

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http://dx.doi.org/10.1055/s-0040-1710051DOI Listing