Search our Database of Scientific Publications and Authors

I’m looking for a

    3969 results match your criteria American Journal of Perinatology[Journal]

    1 OF 80

    Approach to Infants Born Through Meconium Stained Amniotic Fluid: Evolution Based on Evidence?
    Am J Perinatol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Pediatrics, University of California, Davis, California.
    Meconium-stained amniotic fluid (MSAF) during delivery is a marker of fetal stress. Neonates born through MSAF often need resuscitation and are at risk of meconium aspiration syndrome (MAS), air leaks, hypoxic-ischemic encephalopathy, extracorporeal membrane oxygenation (ECMO), and death. The neonatal resuscitation approach to MSAF has evolved over the last three decades. Read More

    Antenatal Medical Therapies to Improve Lung Development in Congenital Diaphragmatic Hernia.
    Am J Perinatol 2018 Jan 16. Epub 2018 Jan 16.
    The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.
    Congenital diaphragmatic hernia (CDH) is a birth defect characterized by failed closure of the diaphragm, allowing abdominal viscera to herniate into the thoracic cavity and subsequently impair pulmonary and vascular development. Despite improving standardized postnatal management, there remains a population of severe CDH for whom postnatal care falls short. In these severe cases, antenatal surgical intervention (fetoscopic endoluminal tracheal occlusion [FETO]) may improve survival; however, FETO increases the risk of preterm delivery, is not widely offered, and still fails in half of cases. Read More

    Can Neonatal Brain MRI be Performed during Active Cooling?
    Am J Perinatol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Pediatrics, University of Florida, Gainesville, Florida.
    Objective:  Due to logistical constraints, physicians traditionally delay diagnostic imaging for neonatal hypoxic-ischemic encephalopathy (HIE) until the neonate has completed all 72 hours of therapeutic hypothermia and rewarming. In some cases, neonates may require neuroimaging before 72 hours has passed.

    Study Design:  We present a case in which an MRI was acquired during active hypothermia. Read More

    Effect of Maternal Body Mass Index and Amniotic Fluid Index on the Accuracy of Sonographic Estimation of Fetal Weight in Late Gestation.
    Am J Perinatol 2018 Jan 10. Epub 2018 Jan 10.
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Hofstra Northwell School of Medicine, North Shore University Hospital, Manhasset, New York.
    Objective:  The objective of this study was to determine the effect, if any, of maternal body mass index (BMI) and amniotic fluid index (AFI) on the accuracy of sonographic estimated fetal weight (EFW) at 40 to 42 weeks' gestation.

    Methods:  This was a retrospective cohort study of singleton gestations with ultrasound performed at 40 to 42 weeks from 2010 to 2013. In this study, patients with documented BMI and sonographic EFW and AFI, concurrently, within 7 days of delivery were included. Read More

    Fatigue during Chest Compression Using a Neonatal Patient Simulator.
    Am J Perinatol 2018 Jan 10. Epub 2018 Jan 10.
    Department of Pediatrics, OUHSC-University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
    Objective:  The objective of this study was to evaluate chest compression (CC) quality and operator fatigue during CC, with coordinated ventilation, on a neonatal simulator and to explore its association with provider aerobic activity and body mass index.

    Methods:  This was a prospective observational experimental study on pediatricians, neonatologists, and neonatal nurses who frequently deliver newborns and who have signed the informed consent. Subjects performed CC coordinated with ventilations at a ratio of 3:1 for 10 minutes on a neonatal mannequin. Read More

    Risks of Preterm Premature Rupture of Membranes and Preterm Birth Post Fetoscopy Based on Location of Trocar Insertion Site.
    Am J Perinatol 2018 Jan 10. Epub 2018 Jan 10.
    Florida International University, Herbert Wertheim School of Medicine, Miami, Florida.
    Objective:  The objective of this study was to assess whether the location of the trocar insertion site for laser treatment of twin-twin transfusion syndrome was associated with preterm-premature rupture of membranes (PPROM) and preterm birth (PTB).

    Study Design:  In this study trocar location was documented in the operating room. Lower uterine segment (LUS) location was defined as any insertion <10 cm vertically from the pubic symphysis. Read More

    Neonatal Outcomes Associated with Noncephalic Presentation at Delivery in Preterm Birth.
    Am J Perinatol 2018 Jan 8. Epub 2018 Jan 8.
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina.
    Objective:  The objective of this study is to evaluate the effect of noncephalic presentation on neonatal outcomes in preterm delivery.

    Study Design:  In this study a secondary analysis of the BEAM trial was performed. It included women with singleton, liveborn, and nonanomalous fetuses. Read More

    Prenatal Diagnosis of Congenital Diaphragmatic Hernia: Does Laterality Predict Perinatal Outcomes?
    Am J Perinatol 2018 Jan 5. Epub 2018 Jan 5.
    Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California.
    Objective:  The objective of this study was to examine laterality as a predictor of outcomes among fetuses with prenatally diagnosed congenital diaphragmatic hernia (CDH).

    Methods:  This is a retrospective cohort study of pregnancies with CDH evaluated at our center from 2008 to 2016 compared cases with right-sided CDH (RCDH) versus left-sided CDH (LCDH). The primary outcome was survival to discharge. Read More

    Obstetric History and Likelihood of Preterm Birth of Twins.
    Am J Perinatol 2018 Jan 5. Epub 2018 Jan 5.
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.
    Objective:  The objective of this study was to investigate the relationship between preterm birth in a prior pregnancy and preterm birth in a twin pregnancy.

    Study Design:  We performed a secondary analysis of a randomized controlled trial evaluating 17-α-hydroxyprogesterone caproate in twins. Women were classified as nulliparous, multiparous with a prior term birth, or multiparous with a prior preterm birth. Read More

    Standardizing Second-Trimester Medical Termination: Effects on Clinical Outcomes.
    Am J Perinatol 2018 Jan 5. Epub 2018 Jan 5.
    Division of Maternal-Fetal Medicine, Baylor College of Medicine, Houston, Texas.
    Objective:  The objective of this study was to evaluate length of induction and postdelivery complications before and after implementation of a standardized approach to second-trimester medical termination of pregnancy.

    Study Design:  This was a retrospective cohort study of all women undergoing medical termination of pregnancy between 130/7 and 266/7 weeks of gestation at a single, academic institution from July 1, 2012, through June 30, 2015. The primary outcome was the time from the start of induction of labor to delivery of the fetus. Read More

    Predictive Value of a Persistent Tachycardia to Indicate Impending Perforation in Necrotizing Enterocolitis.
    Am J Perinatol 2018 Jan 3. Epub 2018 Jan 3.
    Department of Surgery, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
    Introduction:  Necrotizing enterocolitis (NEC) is a devastating disease of infancy. Full-thickness bowel wall necrosis may lead to perforation, peritonitis, and death. Timeous clinical diagnosis of impending perforation is imperative. Read More

    A Double-Blind, Randomized, Placebo-Controlled Trial of 17 Alpha-hydroxyprogesterone Caproate in the Management of Preterm Premature Rupture of Membranes.
    Am J Perinatol 2018 Jan 3. Epub 2018 Jan 3.
    Department of Obstetrics and Gynecology, Stanford University, Stanford, California.
    Objective:  The objective of this study was to evaluate whether weekly administration of 17 α-hydroxyprogesterone caproate (17-OHPC) increases the number of women who achieve 34 weeks of gestation after preterm premature rupture of membranes (PPROM).

    Study Design:  We conducted a multicenter double-blind, randomized controlled trial of 17-OHPC versus placebo among women with PPROM. Women with singleton pregnancy, clinically confirmed PPROM, and without evidence of active infection or major fetal malformation between 240/7 and 320/7 weeks of pregnancy were offered enrollment. Read More

    Preterm Preeclampsia with Severe Features: Composite Maternal and Neonatal Morbidities Associated with Fetal Growth Restriction.
    Am J Perinatol 2018 Jan 3. Epub 2018 Jan 3.
    Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.
    Objective:  The objective of this study was to compare adverse pregnancy outcomes between fetuses with estimated fetal weight (EFW) < 10 to > 10% in women with preterm preeclampsia (PE) with severe features.

    Materials And Methods:  All women with preterm PE with severe features and nonanomalous singletons with EFW were identified at a tertiary center. Women with oligohydramnios or absent/reversed umbilical Doppler velocimetry were excluded. Read More

    Impact of Obesity on the Rate of Recurrent Spontaneous Preterm Birth in Women Treated with 17-alpha Hydroxyprogesterone Caproate.
    Am J Perinatol 2018 Jan 2. Epub 2018 Jan 2.
    Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania.
    Objective:  We sought to determine if the rate of recurrent spontaneous preterm birth (PTB) in women treated with 17-α hydroxyprogesterone caproate (17-OHPC) is modified by maternal body mass index (BMI).

    Study Design:  We performed a secondary analysis of the Maternal-Fetal Medicine Units Network omega-3 fatty acid supplementation to prevent recurrent PTB randomized controlled trial. All women received 17-OHPC. Read More

    Polyhydramnios Affecting a Recipient-like Twin: Risk of Progression to Twin-Twin Transfusion Syndrome and Outcomes.
    Am J Perinatol 2017 Dec 29. Epub 2017 Dec 29.
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California.
    Objective:  The significance of polyhydramnios of one twin in the absence of oligohydramnios of the cotwin in monochorionic diamniotic (MCDA) twin pregnancies (polyhydramnios affecting a recipient-like twin [PART]) is unknown. Our aim is to assess the risk of progression to twin-twin transfusion syndrome (TTTS) with PART, progression to ≥ stage II TTTS, and neonatal survival.

    Study Design:  This study was a retrospective cohort study of MCDA twin pregnancies with PART evaluated at a referral center from 2008 to 2015. Read More

    Epidurals and the Modern Labor Curve: How Epidural Timing Impacts Fetal Station during Active Labor.
    Am J Perinatol 2017 Dec 29. Epub 2017 Dec 29.
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri.
    Objective:  The objective of this study was to estimate epidural timing's impact on fetal station during active labor.

    Study Design:  This secondary analysis of a single-institution prospective cohort study included all term singleton pregnancies, stratified by parity. Those with early epidurals (placed at <6 cm) were compared with those with late epidurals (placed at ≥6 cm). Read More

    Risk of Neonatal Neurologic Morbidity in Advancing Term Gestations.
    Am J Perinatol 2017 Dec 29. Epub 2017 Dec 29.
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri.
    Objective:  Placental insufficiency is associated with neonatal neurologic morbidity and late-term gestations (410/7-416/7 weeks). Whether late-term infants are at increased risk of neurologic morbidity compared with term infants (390/7-406/7 weeks) remains unclear. We aim to compare risk of neurologic morbidity among late-term and term infants. Read More

    Accuracy of Ultrasound Estimated Fetal Weight in Small for Gestational Age and Appropriate for Gestational Age Grown Periviable Neonates.
    Am J Perinatol 2017 Dec 29. Epub 2017 Dec 29.
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Magee-Womens Hospital, Pittsburgh, Pennsylvania.
    Objective:  Clinicians use estimated fetal weight (EFW) as a proxy for birth weight (BW) in the antenatal period. Our objective was to compare the accuracy of EFW obtained by ultrasound to BW among infants born during the periviable period and determine if accuracy of EFW varied among small for gestational age (SGA) versus appropriate for gestational age (AGA) grown neonates.

    Study Design:  We included women who delivered between 230/7 and 256/7 weeks' gestation and had an EFW within 7 days of delivery. Read More

    Outcomes of Medically Indicated Preterm Births Differ by Indication.
    Am J Perinatol 2017 Dec 29. Epub 2017 Dec 29.
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, The University of Alabama at Birmingham, Birmingham, Alabama.
    Objective:  We aim to examine whether outcomes of preterm birth (PTB) are further modified by the indication for delivery.

    Study Design:  We performed a retrospective cohort study of all singletons delivered at 23 to 34 weeks from 2011 to 2014. Women were classified by their primary indication for delivery: maternal (preeclampsia) or fetal/obstetric (growth restriction, nonreassuring fetal status, and vaginal bleeding). Read More

    Traumatic Neonatal Lumbar Punctures: Experience at a Large Pediatric Tertiary Care Center in Canada.
    Am J Perinatol 2017 Dec 29. Epub 2017 Dec 29.
    Division of Infectious and Immunological Diseases, Department of Pediatrics, BC Children's Hospital, Vancouver, British Columbia, Canada.
    Objective:  Contamination of cerebrospinal fluid (CSF) by blood during neonatal lumbar puncture (LP) is common and poses diagnostic difficulties. Our objectives were to determine the number of traumatic LPs performed at the BC Children's Hospital over 9 years and whether there was an association between traumatic LPs and demographic variables, hospital location, or time of the procedure.

    Study Design:  This study was a retrospective review of neonatal CSF samples from May 2006 to March 2015. Read More

    Procalcitonin as Predictor of Bacterial Infection in Meconium Aspiration Syndrome.
    Am J Perinatol 2017 Dec 29. Epub 2017 Dec 29.
    Department of Microbiology, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi, India.
    Background:  There is a lack of definite consensus on indications for initiating antibiotics in neonates with meconium aspiration syndrome (MAS), instigating researchers to search for a biomarker that can help differentiate MAS from MAS with bacterial infection.

    Objective:  Our primary objective was to compare serum procalcitonin (PCT) levels in full-term vigorous neonates having MAS with or without bacterial infection.

    Materials And Methods:  Seventy term vigorous neonates with diagnosis of MAS were enrolled. Read More

    Liver Injury in Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome Measured by Diffusion-Weighted Magnetic Resonance Imaging.
    Am J Perinatol 2017 Dec 27. Epub 2017 Dec 27.
    Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, Texas.
    Objective:  The objective of this study was to evaluate acute liver injury (ALI) detected by diffusion-weighted magnetic resonance imaging (MRI) and the associated laboratory findings in women with hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome.

    Study Design:  This was a retrospective, observational study of women with HELLP syndrome defined by serum aspartate aminotransferase (AST) levels ≥100 U/L and thrombocytopenia with platelets ≤100,000/µL. All women underwent MRI postpartum including diffusion-weighted imaging to estimate the volume of ALI with reconstructed apparent diffusion coefficient (ADC) maps. Read More

    Estimated Placental Volume and Gestational Age.
    Am J Perinatol 2017 Dec 27. Epub 2017 Dec 27.
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut.
    Objective:  The objective of this study was to validate estimated placental volume (EPV) across a range of gestational ages (GAs).

    Study Design:  Three hundred sixty-six patients from 2009 to 2011 received ultrasound scans between 11 + 0 and 38 + 6 weeks GA to assess EPV. An EPV versus GA best fit curve was generated and compared with published normative curves of EPV versus GA in a different population. Read More

    Stroke Volume Recruitability during the Third Trimester of Pregnancy.
    Am J Perinatol 2017 Dec 26. Epub 2017 Dec 26.
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas.
    Objective:  It is unknown whether the heart operates in the ascending or flat portion of the Starling curve during normal pregnancy. Pregnant women do not respond to the passive leg-raising maneuver secondary to mechanical obstruction of the inferior vena cava by the gravid uterus. Our objective was to evaluate if administration of a fluid bolus increases baseline stroke volume (SV) among healthy pregnant patients during the third trimester. Read More

    Nonsurgical Management of Persistent and Hemodynamically Significant Patent Ductus Arteriosus among Extremely Low Birth Weight Infants: A Propensity Score Matched Analysis.
    Am J Perinatol 2017 Dec 19. Epub 2017 Dec 19.
    Division of Neonatology, Department of Pediatrics, University of South Alabama, Mobile, Alabama.
    Objective:  The objective of this study was to evaluate the impact of a nonsurgical approach (with the incorporation of late postnatal hydrocortisone treatment to facilitate extubation) in comparison to the surgical approach for the management of persistent hemodynamically significant patent ductus arteriosus (hsPDA) among chronically ventilator-dependent extremely low birth weight (ELBW) infants.

    Methods:  In this retrospective study, ELBW infants with a diagnosis of hsPDA (diagnosed based on the echocardiographic criteria and chronic ventilator dependence) that were persistent beyond 14 days of postnatal age despite adequate medical treatment were included.

    Results:  Out of 127 infants (surgical approach group, n = 67 and nonsurgical approach group, n = 60), 72 infants were matched based on the propensity scores. Read More

    Epigenetic Regulation of the Nitric Oxide Pathway, 17-α Hydroxyprogesterone Caproate, and Recurrent Preterm Birth.
    Am J Perinatol 2017 Dec 14. Epub 2017 Dec 14.
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.


    Characterization of Thermal and Mechanical Indices from Serial Ultrasound Exams and Associations with Neonatal Anthropometry: The NICHD Fetal Growth Studies.
    Am J Perinatol 2017 Nov 30. Epub 2017 Nov 30.
    Division of Intramural Population Health Research, Department of Epidemiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.

    Neonatal Outcomes Differ after Spontaneous and Indicated Preterm Birth.
    Am J Perinatol 2017 Nov 28. Epub 2017 Nov 28.
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis Children's Hospital, St. Louis, Missouri.


    Morbidity Associated with Fetal Macrosomia among Women with Diabetes Mellitus.
    Am J Perinatol 2017 Nov 28. Epub 2017 Nov 28.
    Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.

    Impact of Intended Mode of Delivery on Outcomes in Preterm Growth-Restricted Fetuses.
    Am J Perinatol 2017 Nov 28. Epub 2017 Nov 28.
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, School of Medicine at the University of Alabama at Birmingham, Birmingham, Alabama.

    Perianal Dermatitis, Its Incidence, and Patterns of Topical Therapies in a Level IV Neonatal Intensive Care Unit.
    Am J Perinatol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Pediatrics, West Virginia University School of Medicine, Morgantown, West Virginia.
    Objective To define the incidence of perianal dermatitis (PD) and determine the usage pattern and cost efficacy of diaper products among neonates admitted to a level IV neonatal intensive care unit (NICU) including those with a diagnosis of neonatal abstinence syndrome (NAS). Methods A retrospective cohort study to evaluate neonates with PD based on number of orders for Aquaphor, Bagbalm, Desitin, Flanders, or Nystatin. Various demographic and clinical parameters were recorded. Read More

    1 OF 80