1,069 results match your criteria American Journal of Pediatric Hematology/Oncology[Journal]


Transient abnormal myelopoiesis in Down's syndrome neonates.

Authors:
Y L Kwong

Am J Pediatr Hematol Oncol 1994 Nov;16(4):387-8

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November 1994
2 Reads

Maternal malignancy involving the products of conception: a report of malignant melanoma and medulloblastoma.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):380-3

Department of Pediatrics, Centre Hospitalier Universitaire-Sherbrooke, University of Sherbrooke, Quebec, Canada.

Purpose: Cancer in pregnancy is not uncommon, but cases of maternal malignancy involving the placenta or the fetus are much more rare. We report two additional cases.

Patients And Methods: We report one case of malignant melanoma discovered during pregnancy and found to have metastasized to the placenta. Read More

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November 1994
20 Reads

Sphenoid sinus involvement in neuroblastoma.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):377-9

Hematology/Oncology Division, Children's Hospital Medical Center, Cincinnati, OH 45229.

Purpose: Malignancy of the sphenoid sinus, especially metastatic involvement, is an extremely rare event at any age and is usually associated with a poor prognosis. We present a case of a 5-year-old boy who underwent allogenic bone marrow transplantation for stage IV neuroblastoma.

Patients And Methods: Three years later, he presented with an isolated lesion, histologically proven to be neuroblastoma, in the sphenoid sinus. Read More

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November 1994
8 Reads

Transient lupus anticoagulant associated with prothrombin deficiency: unusual cause of bleeding in a 5-year-old girl.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):372-6

Department of pathology, University of Virginia Health Sciences Center,Charlottesville 22908.

Purpose: We present the association of a lupus anticoagulant with hypoprothrombinemia in a 5-year-old girl, who presented with ecchymoses and a hematoma. This coagulopathy should be included in the differential of bleeding in the previously healthy children.

Patients And Methods: Coagulation and immunology laboratory evaluation was performed at the time of presentation with bleeding and 2 months later, after complete clinical recovery. Read More

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November 1994
8 Reads

Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):368-71

Department of Pediatrics, West Virginia University School of Medicine, Morgantown 26506.

Purpose: We report a case of infection-associated hemophagocytic syndrome in the setting of disseminated histoplasmosis.

Patients And Methods: A 6-year-old boy with chronic mucocutaneous candidiasis developed a fulminant hemophagocytic syndrome. Evaluation for an infectious cause included bacterial, mycobacterial, viral, and fungal cultures, serological assessment, and histological examination of bone marrow and bronchoalveolar lavage fluid. Read More

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November 1994
4 Reads

Postpheochromocytoma erythropoietin-dependent erythrocytosis. A postischemic mechanism?

Authors:
M Bosio G Barosi

Am J Pediatr Hematol Oncol 1994 Nov;16(4):365-7

Department of Pediatrics, Magenta Hospital, Italy.

Purpose: Erythropoietin-dependent pure erythrocytosis (EDPE) is a rare disorder caused by idiopathic hypererythropoietinemia. We describe a 13-year-old girl who developed an EDPE-like erythrocytosis after removal of an adrenal pheochromocytoma.

Patients And Methods: As occurs in EDPE, this post-pheochromocytoma erythrocytosis was associated with a high serum erythropoietin (s-Epo) level that maintained physiological regulation. Read More

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November 1994
2 Reads

Congenital mesoblastic nephroma with metastasis to the brain: a case report.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):361-4

Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York.

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November 1994
2 Reads

Prenatal detection of neuroblastoma by fetal ultrasonography.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):356-60

Department of Pediatrics, Arkansas Children's Hospital, Little Rock 72202.

Purpose: We report three cases of neuroblastoma diagnosed by prenatal ultrasound examination and examine the biologic features of tumors diagnosed prenatally.

Patients And Methods: Neuroblastoma is the most common tumor detected in the newborn period. Thus, some of these tumors develop prenatally and should be detectable by maternal ultrasound. Read More

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November 1994
3 Reads

Transient erythroblastopenia of the newborn caused by human parvovirus.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):352-5

Department of Pediatrics, New York Medical College, Valhalla 10595.

Purpose: We describe a newborn baby boy with anemia in whom human parvovirus (HPV) antibodies were detected in his serum.

Patients And Methods: Severe reticulocytopenia and anemia lasted until day 11 after his birth. Thereafter reticulocytosis was observed. Read More

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November 1994
3 Reads

Typhlitis in a patient with acute lymphoblastic leukemia prior to the administration of chemotherapy.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):348-51

Department of Pathology, Rhode Island Hospital 02903.

Patients And Methods: A 3-year-old girl with acute lymphoblastic leukemia developed typhlitis immediately after diagnosis and before the institution of chemotherapy.

Purpose: Typhlitis is a necrotizing colitis that develops in immunodeficient patients with severe neutropenia. Most patients are leukemic children who are receiving or have received chemotherapy. Read More

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November 1994
4 Reads

Novel germline mutation of the p53 tumor suppressor gene in a child with incidentally discovered adrenal cortical carcinoma.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):341-7

Department of Pediatrics, University of Texas Health Science Center, San Antonio 78284-7810.

Purpose: We report a case of adrenal cortical carcinoma in an infant, which was incidentally discovered by renal sonography after a urinary tract infection. The previous death of a sibling after rhabdomyosarcoma in infancy prompted a search for a heritable p53 tumor suppressor gene mutation in this family.

Patients And Methods: Starting with frozen adrenal carcinoma tissue, polymerase chain reaction (PCR) amplification followed by direct sequencing of exons 4-8 of p53 was used to search for a mutation. Read More

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November 1994
5 Reads

Human immunodeficiency virus infection presenting as pancytopenia in an infant.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):334-7

Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903-0019.

Case Report: A 14-month-old infant presented with pancytopenia and Mycobacterium avium intracellularae (MAI) as the initial manifestation of acquired immunodeficiency syndrome (AIDS).

Conclusion: Human immunodeficiency virus (HIV-1) infections should be considered in the differential diagnosis of infants and children with cytopenias. Read More

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November 1994
3 Reads

Chronic parvovirus infection mimicking myelodysplastic syndrome in a child with subclinical immunodeficiency.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):329-33

Department of Pediatrics, Odense University Hospital, Denmark.

Purpose: We present a report of a child with subclinical immunodeficiency who became chronically infected with parvovirus resulting in pancytopenia and morphologic abnormalities in the bone marrow mimicking myelodysplastic syndrome (MDS).

Patients: An 8-year-old boy presented with severe anemia, moderate thrombocytopenia and granulocytopenia. The patient showed hyper-immunoglobulin M (IgM) immunodeficiency but no increased susceptibility to infections. Read More

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November 1994
4 Reads

Treatment of recurrent suprahyoid cervicofacial lymphangioma with intravenous cyclophosphamide.

Authors:
C Turner S Gross

Am J Pediatr Hematol Oncol 1994 Nov;16(4):325-8

Department of Pediatrics, College of Medicine, University of Florida, Gainesville 32610-0296.

Purpose: Surgical resection of cervicofacial cystic hygromas and lymphangiomas rarely effects complete reduction because of severe anatomic restrictions.

Patients And Methods: With prior knowledge of cyclophosphamide activity against lesions of this type, a formal trial of cyclophosphamide was initiated.

Results: Overall dose escalation therapy resulted in 50% reduction in mass without recurrence after cessation of therapy and with minimal and readily reversible toxicity. Read More

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November 1994
9 Reads

Transient erythroblastopenia of childhood. Prospective study of fifty patients.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):320-4

Schneider Children's Hospital of Long Island Jewish Medical Center, New Hyde Park, NY 11042.

Purpose: To prospectively evaluate 50 patients with transient erythroblastopenia of childhood (TEC) at a single institution in order to compare those patients presenting with reticulocytopenia (group I) with those presenting in the recovery phase with reticulocytosis (group II); to further describe the clinical course of this common pediatric hematological disorder in a large number of patients, particularly the effect on the neutrophils; and to review the available literature regarding this disorder.

Patients And Methods: Fifty patients presenting to the Children's Hospital from September 1983 to September 1991 were prospectively evaluated. Those patients with a reticulocytosis and in recovery at the time of diagnosis were included and compared with those with reticulocytopenia. Read More

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November 1994
3 Reads

Childhood idiopathic thrombocytopenic purpura: association with human parvovirus B19 infection.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):314-9

Texas Children's Cancer Center, Texas Children's Hospital, Houston 77030.

Purpose: Infection with human parvovirus B19 is the most common cause of transient aplastic crisis in patients with chronic hemolytic anemia. Multiple reports of children with simultaneous B19 infection and thrombocytopenia as well as the known association between experimental B19 infection and thrombocytopenia prompted us to hypothesize that B19 may be associated with childhood idiopathic, or immune, thrombocytopenic purpura (ITP). Because there is a paucity of evidence regarding a viral etiology for ITP, we performed a comprehensive study to explore its possible relationship to B19 infection. Read More

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November 1994
4 Reads

Prevalence of antibodies to hepatitis C virus in transfused children with cancer.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):309-13

Department of Pediatrics, Baystate Medical Center, Springfield, Massachusetts 01199.

Purpose: Hepatitis C virus (HCV) transmission is a well-documented complication of blood transfusions, although data on transfused children with cancer is sparse. Using a newer assay for anti-HCV antibodies, the prevalence of HCV infection was determined in a population of children with cancer in the United States.

Patients And Methods: Forty-five transfused children with cancer were studied for evidence of HCV infection. Read More

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November 1994
3 Reads

Use of caudal block for pain control following bone marrow harvest in children.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):305-8

Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine.

Purpose: After the harvesting of bone marrow for use in transplantation, pain control needs are greatest in the first 12 to 24 hours. This is also the time during which systemic side effects of parenterally administered narcotics are greatest as a result of the recent general anesthetic. We examined the role of regional anesthesia as an adjunct to pain management in pediatric patients undergoing bone marrow harvest. Read More

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November 1994
2 Reads

Pancreatitis associated with brain tumor therapy.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):301-4

Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226.

Purpose: Four children with prolonged emesis during brain tumor therapy were diagnosed with pancreatitis.

Patients And Methods: All were exposed to medications or radiotherapy that potentially contributed to pancreatitis.

Conclusions: Because recognition of pancreatitis may necessitate changes in supportive care, pancreatitis should be included in the differential diagnosis of vomiting in this population. Read More

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November 1994
4 Reads

Refining therapeutic strategies for patients with resistant Wilm's tumor.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):296-300

Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Purpose: Despite the excellent prognosis for 90% of patients with Wilms' tumor, survival remains poor among those with recurrent or advanced disease or tumors of unfavorable histology. We sought to identify a chemotherapy regimen for this subset of patients that offers potential efficacy with minimal nephrotoxicity.

Patients And Methods: Through a review of patients' medical records, we compared the efficacy and nephrotoxicity of ifosfamide, cisplatin, cisplatin/etoposide, and ifosfamide/carboplatin/etoposide (ICE) regimens in 32 patients with recurrent (n = 23), refractory (n = 1), or metastatic (n = 8) Wilms' tumor, including six with tumors having unfavorable histologic features. Read More

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November 1994
7 Reads

Renal toxicity of ifosfamide in pilot regimens of the intergroup rhabdomyosarcoma study for patients with gross residual tumor.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):286-95

Rhabdomyosarcoma Study Committee of the Childrens Cancer Group, Duke University Medical Center.

Purpose: The purpose of this review is to characterize the nephrotoxicity noted in newly diagnosed patients under 21 years of age after treatment with ifosfamide-containing chemotherapy regimens and local irradiation for localized gross residual rhabdomyosarcoma or undifferentiated sarcoma.

Patients And Methods: From 1987 to 1991, 194 previously untreated patients received vincristine and ifosfamide plus dactinomycin or etoposide for 1-2 years. Ifosfamide was given at 1. Read More

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November 1994
3 Reads

Recombinant human granulocyte colony stimulating factor in cyclic neutropenia: use of a new 3-day-a-week regimen.

Am J Pediatr Hematol Oncol 1994 Nov;16(4):338-40

Section of Pediatric Hematology/Oncology, New York Medical College, Valhalla.

Background: G-CSF has been shown to be beneficial in cyclic neutropenia when given as a daily subcutaneous injection. We investigated the usefulness of a new three-day-a-week regimen.

Methods: A ten year old boy with cyclic neutropenia was initially treated with G-CSF 7 micrograms/kg given on alternate days for seven months. Read More

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November 1994
3 Reads

Sarcoidosis in a child with sickle cell anemia.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):278-82

Department of Pediatrics (Hematology-Oncology), University of Cincinnati School of Medicine, Ohio.

Purpose: The purpose of this case report is to (a) present a detailed description of a child with sickle cell anemia who developed sarcoidosis, (b) compare the clinical aspects of sickle cell anemia and sarcoidosis, and (c) review the literature with respect to the coincidence of these two diseases. Detailed clinical case history and laboratory findings are presented. A literature review of other case reports with children and adults who have both sickle cell anemia and sarcoidosis is given. Read More

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August 1994
3 Reads

Successful treatment of multisystem Langerhans cell histiocytosis (histiocytosis X) with etoposide.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):275-7

Department of Pediatrics, LSU Medical Center, New Orleans 70112-2822.

Purpose: Langerhans cell histiocytosis (LCH) in its disseminated form usually occurs in the very young, and has a fulminant, rapidly progressive, and fatal course despite different forms of therapy.

Patients And Methods: We treated two patients, who had failed on vinblastine treatment, with i.v. Read More

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August 1994
2 Reads

Transient erythroblastopenia in a child with Kawasaki syndrome: a case report.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):271-4

Schneider Children's Hospital of the Long Island Jewish Medical Center, New Hyde Park, NY 11042.

Purpose: We describe for the first time the case of a child with Kawasaki syndrome and associated transient erythroblastopenia.

Patients And Methods: A 5 1/2-month-old infant with Kawasaki syndrome as evidenced by lymphadenopathy, fever, rash conjunctival injection, and extremity changes had associated anemia and reticulocytopenia requiring transfusion and thrombocytopenia. Bone marrow aspiration was consistent with a transient erythroblastopenia. Read More

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August 1994
3 Reads

Recurrent benign intracranial hypertension due to iron deficiency anemia. Case report and review of the literature.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):266-70

Department of Pediatric Hematology/Oncology, New York Medical College, Valhalla 10505.

Purpose: Iron deficiency anemia (IDA) causes benign intracranial hypertension (BIH).

Patients And Methods: A case of an 11-year-old girl with severe IDA and benign intracranial hypertension is presented.

Results: Treatment of iron deficiency resulted in the resolution of BIH. Read More

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August 1994
2 Reads

Red cell aplasia resembling Diamond-Blackfan anemia in seven children in a family.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):260-5

Department of Pediatrics, Faculty of medicine, University of Jordan, Amman.

Patients And Methods: Seven children of the same family with a possible variant of Diamond-Blackfan anemia (DBA) are reported. Five were male siblings, and the other two were their cousins, one male and one female. All were products of consanguineous marriages of healthy parents. Read More

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August 1994
2 Reads

Splenic rupture in hemophilia.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):255-9

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas.

Purpose: Little information is available regarding splenic injury in patients with hemophilia. We describe here the management of splenic rupture in five of our patients with hemophilia and summarize the literature describing this complication.

Patients And Methods: Two human immunodeficiency virus-seropositive patients were managed medically and did not require splenectomy. Read More

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August 1994
3 Reads

Development of antibodies to bovine and human factor V in two children after exposure to topical bovine thrombin.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):249-54

Department of Pediatrics, University of Manitoba, Winnipeg, Canada.

Purpose: Acquired inhibitors to coagulation factors are rare in pediatric patients. Exposure to topical bovine thrombin is a risk factor for the development of inhibitors in adult cardiac surgery patients. We report two pediatric patients who developed inhibitors to bovine and human factor V after exposure to fibrin glue containing bovine thrombin. Read More

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August 1994
2 Reads

Transient erythroblastopenia of childhood in infants < 6 months of age.

Authors:
R Miller B Berman

Am J Pediatr Hematol Oncol 1994 Aug;16(3):246-8

Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106.

Purpose: During a 6-year period, we identified six infants < 6 months of age with transient erythroblastopenia of childhood (TEC).

Patients And Methods: All patients presented with moderate to severe anemia, reticulocytopenia, and age-appropriate mean corpuscular volume and fetal hemoglobin level.

Results: Severe aregenerative anemia in an infant < 6 months of age often raises the diagnostic possibility of Diamond Blackfan anemia (DBA). Read More

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August 1994
4 Reads

Tropisetron (ICS 205-930) in pediatric oncology: first results in patients refractory to antiemetic metoclopramide-based treatments.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):242-5

Division of Pediatric Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

Purpose: We evaluated the antiemetic efficacy of tropisetron, a 5-HT3 receptor antagonist, during its compassionate use in children with malignant disease who during previous chemotherapy cycles experienced emesis refractory to metoclopramide-based treatments.

Patients And Methods: Tropisetron was given to 15 children (eight boys and seven girls 18 months to 18 years of age) with miscellaneous neoplasms. Generally 5 mg/day of tropisetron was administered i. Read More

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August 1994
3 Reads

Prevention of chemotherapy-induced emesis with granisetron in children with malignant diseases.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):236-41

Department of Pediatrics, Nagoya University School of Medicine, Japan.

Purpose: In a prospective crossover study, we evaluated the safety and antiemetic activity of granisetron, a 5-hydroxytryptamine3 (5-HT3) receptor antagonist, compared with conventional antiemetics regimen, including metoclopramide, in pediatric cancer patients.

Patients And Methods: Twenty-two children with malignant diseases were enrolled. The chemotherapy included cytarabine 3 g/m2 (regimen A), cisplatin 90 mg/m2 (regimen B), and actinomycin D 900 micrograms/m2 plus ifosfamide 3 g/m2 (regimen C). Read More

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August 1994
3 Reads

The efficacy and safety of granisetron in pediatric cancer patients who had failed standard antiemetic therapy during anticancer chemotherapy.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):231-5

Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.

Purpose: This study was undertaken to evaluate the safety and efficacy of granisetron (a 5-hydroxytryptamine. antagonist) in children with malignant disease who had previously experienced unacceptable nausea and vomiting and/or adverse effects associated with standard antiemetic therapy.

Patients And Methods: Thirty children 3-18 years of age who were receiving anticancer chemotherapy were enrolled in the study. Read More

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August 1994
3 Reads

Does weight for height have prognostic significance in children with acute lymphoblastic leukemia?

Am J Pediatr Hematol Oncol 1994 Aug;16(3):225-30

Department of Human Nutrition, University of Glasgow, Yorkhill Hospitals, Scotland.

Purpose: We tested the hypothesis that weight for height, a simple index of nutritional status, is related to prognosis in childhood acute lymphoblastic leukemia (ALL).

Patients And Methods: The study population was composed of 78 children with ALL tested at one U.K. Read More

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August 1994
2 Reads

Pain in children and adolescents with sickle cell anemia: a prospective study utilizing self-reporting.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):219-24

Department of Pharmacy, Medical University of South Carolina, Charleston 29425.

Purpose: The purpose of this study was to characterize pain reporting among children with sickle cell anemia (SCA) experiencing painful vaso-occlusive crises. These patients were managed according to a protocol based on self-reports of pain.

Patients And Methods: Seventeen children (3-18 years) with SCA (Hb SS) who were admitted for painful crisis were asked to report their pain according to a rating scale of 0-5. Read More

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August 1994
2 Reads

Serum erythropoietin levels in term and preterm infants during the first year of life.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):213-8

Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Purpose: To evaluate the kinetics of erythropoietin (EPO) production and address the pathogenesis of anemia of prematurity, we measured EPO levels in infants during the first year of life.

Patients And Methods: Using a radioimmunoassay, serum EPO levels were measured in 97 infants classified into three groups according to weight: group A, n = 40, < 1,500 g; group B, n = 19, 1,500-2,499 g; and group C, n = 38, > or = 2,500 g.

Results: The serum EPO level ranged widely during the early neonatal period from days 0 to 6 (group A, < 5 to 307 mU/ml; group B, 10-340 mU/ml; and group C, 9-108 mU/ml). Read More

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August 1994
3 Reads

The effect of chemotherapy dose intensity on the hematological toxicity of the treatment for Wilms' tumor. A report from the National Wilms' Tumor Study.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):207-12

Department of Pediatrics, Roswell Park Cancer Institute, Buffalo, NY 14263.

Purpose: To determine the relationship between hematological toxicity and actual dose intensity of treatment of patients randomized to therapy during the first 28 months of the National Wilms' Tumor Study-4.

Methods: The mean minimum white blood cell count (WBC), platelet count (PLT), hemoglobin, and absolute neutrophil count (ANC) during the first two courses of chemotherapy and the mean number of days of hospitalization for toxicity were compared between standard and "pulse-intensive" regimens for all randomized patients entered on National Wilms' Tumor Study-4 between August 6, 1986 and December 31, 1988. The mean dose intensity of dactinomycin, vincristine, and doxorubicin received during the first two courses and the entire course of treatment was compared between standard and "pulse-intensive" regimens. Read More

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August 1994
4 Reads

Megakaryocyte growth in vitro predicts outcome in idiopathic thrombocytopenic purpura.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):194-9

Department of Pediatrics (Inselspital), University of Bern, Switzerland.

Purpose: The impact of megakaryocyte growth in vitro on clinical data, especially outcome, was studied in 25 consecutive children with idiopathic thrombocytopenic purpura (ITP).

Patients And Methods: Twenty children with untreated de novo ITP and five children with pretreated ITP were evaluated. The number of megakaryocyte colonies (cloning efficiency), the mean cell number per colony (mitotic amplification) and the percentages of polyploid megakaryocytes after 7 and 12 days in culture (relative size of the endomitotic compartment) were determined in two separate clonal assays. Read More

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August 1994
3 Reads

Current controversy: is computed tomography scan of the chest needed in patients with Wilms' tumor?

Authors:
M D Cohen

Am J Pediatr Hematol Oncol 1994 Aug;16(3):191-3

Department of Radiology, Riley Hospital for Children, Indiana University Medical Center, Indianapolis 46202-5200.

Purpose: Reports from the National Wilms' Tumor Study (NWTS) Group on the subject of chest computed tomography (CT) versus chest radiograph for the detection of lung metastases from Wilms tumor are reviewed.

Patients And Methods: Thirty-two patients with lung nodules detected by CT, with negative chest radiographs, were identified. Five patients were excluded from further analysis. Read More

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August 1994
3 Reads

Autologous peripheral blood cell transplantation in the treatment of advanced neuroblastoma.

Am J Pediatr Hematol Oncol 1994 Aug;16(3):200-6

Minneapolis Children's Medical Center, Minnesota.

Purpose: We review the experience with autologous peripheral blood cell transplantation (APBCT) in children with neuroblastoma at the University of Minnesota.

Patients And Methods: Aspects of peripheral blood cell collection and use in nine patients who had advanced neuroblastoma (eight Evans stage IV, 1 stage III), who were median age 4 years (range 10 months-22 years) and who were treated with high-dose chemotherapy without total body irradiation and APBCT between September 1987 and December 1989 are reviewed.

Results: A median of 4. Read More

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August 1994
3 Reads

Idiopathic thrombocytopenia and neutropenia in childhood.

Am J Pediatr Hematol Oncol 1994 May;16(2):95-101

Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.

Purpose: Between 1975 and 1990, 13 patients seen at The Hospital for Sick Children, Toronto, Ontario, were noted to have concurrent idiopathic thrombocytopenia and neutropenia (ITN; platelet count < 150 x 10(9)/L; absolute neutrophil count < 1.5 x 10(9)/L). These patients all had normal marrow function and no evidence of systemic disease. Read More

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May 1994
2 Reads

Magnetic resonance imaging visualization of hemorrhage into a suprapatellar pouch in a child with hemophilia.

Am J Pediatr Hematol Oncol 1994 May;16(2):183-5

Mountain States Regional Hemophilia Center, University of Colorado School of Medicine, Denver 80262.

Purpose: Magnetic resonance imaging (MRI) was used for evaluation of refractory joint swelling in a 7-year-old boy with hemophilia.

Patient And Methods: This patient with no evidence of an inhibitory had refractory left knee swelling despite receiving appropriate factor VIII concentrate infusions.

Results: A plain radiograph showed soft tissue swelling and a calcification in the left suprapatellar region. Read More

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May 1994
2 Reads

Acute splenic sequestration in the absence of palpable splenomegaly.

Am J Pediatr Hematol Oncol 1994 May;16(2):181-2

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710.

Purpose: Acute splenic sequestration in children with sickle hemoglobinopathies is a medical emergency characterized by splenomegaly, anemia, and thrombocytopenia.

Patients And Methods: We describe a young girl with hemoglobin SC disease who experienced an acute splenic sequestration without palpable splenomegaly.

Conclusions: We emphasize the need for a high index of suspicion for splenic sequestration and the utility of ultrasonography in documenting splenomegaly. Read More

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May 1994
3 Reads

Failure to thrive is an early symptom of the imerslund Gräsbeck syndrome.

Am J Pediatr Hematol Oncol 1994 May;16(2):177-80

Department of Hematology, University Hospital for Children and Youth het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands.

Purpose: The Imerslund-Gräsbeck syndrome (IGS) is a rare inherited disorder characterized by a megaloblastic anemia due to a selective vitamin B12 malabsorption in association with a mild proteinuria. Usually recurrent infections, gastrointestinal complaints, and pallor are presenting symptoms. We report two cases of IGS with an unusual presentation. Read More

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May 1994
4 Reads

Type II congenital dyserythropoietic anemia in a patient with ectodermal dysplasia. Distinction from dyskeratosis congenita.

Am J Pediatr Hematol Oncol 1994 May;16(2):173-6

Division of Hematology/Oncology, New York Hospital, Cornell University Medical Center, New York.

Purpose: We describe a patient who presented with severe anemia and ectodermal dysplasia.

Patients And Methods: This is a case report of a patient whose anemia was evaluated at New York Hospital and then returned to Australia where further testing was performed.

Results: The history indicated that this was a chronic anemia. Read More

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May 1994
3 Reads

Persistence and possible progression of a pelvic neuroblastoma detected by mass screening during 19 months.

Am J Pediatr Hematol Oncol 1994 May;16(2):164-6

Department of Pediatrics, McGill University, Montreal, Quebec, Canada.

Purpose: The preclinical detection of neuroblastoma by screening for elevated levels of urinary catecholamines often leads to the discovery of children with early-stage, biologically favorable disease. It is uncertain how vigorously therapy must be pursued in such cases. We report an infant whose pelvic mass was initially thought to be a fecaloma, and consequently was not treated for 19 months. Read More

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May 1994
3 Reads

Treatment of refractory Evans syndrome with alternate-day cyclosporine and prednisone.

Am J Pediatr Hematol Oncol 1994 May;16(2):156-9

Section of Pediatric Hematology-Oncology, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis 46202-5225.

Purpose: We report that the use of alternate-day cyclosporine and prednisone improved the clinical course of a 6-year-old child with severe Evans syndrome. Before the use of cyclosporine the child had experienced life-threatening episodes of hemolytic anemia despite the use of multiple therapeutic modalities.

Methods: Cyclosporine was given at a dose of 10 mg/kg/day divided into two doses on alternate days. Read More

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May 1994
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Yersinia enterocolitica infection in a patient with sickle cell disease after exposure to chitterlings.

Am J Pediatr Hematol Oncol 1994 May;16(2):153-5

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Purpose: We describe certain clinical, epidemiologic, and host-susceptibility features of Yersinia enterocolitica infection in the context of a patient with underlying risk factors.

Patients And Methods: A 10-year-old black girl with sickle cell disease receiving chelation therapy for iron overload resulting from chronic transfusion therapy was admitted with acute abdominal pain and fever.

Results: Upon hospital admission, differential diagnoses included enterocolitis, appendicitis, and vasoocclusive crisis. Read More

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May 1994
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Health status of long-term survivors after cancer in childhood. Results of an uniinstitutional study in Italy.

Am J Pediatr Hematol Oncol 1994 May;16(2):143-52

Department of Hematology and Oncology, Istituto Giannina Gaslini (IGG), Genova, Italy.

Purpose: This study aims at defining the frequency and severity of late effects in a series of 288 long-term survivors of childhood cancer treated from 1962 to 1982 at the Giannina Gaslini Children's Research Hospital of Genoa, Italy.

Patients And Methods: All cases with a diagnosis of malignancy in childhood and a minimum of 2.5 years from discontinuation of treatment were considered eligible. Read More

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May 1994
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