339,798 results match your criteria American Journal of Health Studies AJHS [Journal]


Anaesthetic Factors Affecting Outcome After Bariatric Surgery, a Retrospective Levelled Regression Analysis.

Obes Surg 2019 Mar 16. Epub 2019 Mar 16.

Department of General Surgery, AZ Sint Jan Brugge-Oostende, B-8000, Brugge, Belgium.

Background: Deep neuromuscular block (NMB) and opioid-free anaesthesia (OFA) improve surgical workspace and reduce post-operative opioid consumption, but its impact on perioperative outcomes is unknown. This observational study compared complications and healthcare resource utilization after bariatric surgery, with or without continuous deep NMB or OFA.

Methods: We included all 9246 patients who underwent laparoscopic bariatric surgery at our institution from January 2009 to February 2017. Read More

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http://dx.doi.org/10.1007/s11695-019-03763-1DOI Listing

Transgenic crops: trends and dynamics in the world and in Latin America.

Transgenic Res 2019 Mar 16. Epub 2019 Mar 16.

Centro de Investigaciones Económicas, Administrativas y Sociales (CIECAS), Instituto Politécnico Nacional (IPN), Lauro Aguirre 120. Col. Agricultura, Del. Miguel Hidalgo, C. P. 11360, Mexico City, Mexico.

Transgenic crops have been the recipient of strong support as well as vigorously opposed opinions since their appearance. In any case, their growth throughout the world has been remarkable, and the production and commercialization of transgenics in Latin America has been especially significant. The purpose of the present study was to analyze transgenic crop production trends around the world and the relationship between the area allocated to the cultivation of transgenic crops and the profits generated by this activity. Read More

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http://link.springer.com/10.1007/s11248-019-00123-8
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http://dx.doi.org/10.1007/s11248-019-00123-8DOI Listing
March 2019
1 Read

Caffeine inhibits PI3K and mTORC2 in Dictyostelium and differentially affects multiple other cAMP chemoattractant signaling effectors.

Mol Cell Biochem 2019 Mar 16. Epub 2019 Mar 16.

Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, USA.

Caffeine is commonly used in Dictyostelium to inhibit the synthesis of the chemoattractant cAMP and, therefore, its secretion and the autocrine stimulation of cells, in order to prevent its interference with the study of chemoattractant-induced responses. However, the mechanism through which caffeine inhibits cAMP synthesis in Dictyostelium has not been characterized. Here, we report the effects of caffeine on the cAMP chemoattractant signaling network. Read More

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http://dx.doi.org/10.1007/s11010-019-03520-zDOI Listing

Improved in vivo targeting of BCL-2 phenotypic conversion through hollow gold nanoshell delivery.

Apoptosis 2019 Mar 16. Epub 2019 Mar 16.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA.

Although new cancer therapeutics are discovered at a rapid pace, lack of effective means of delivery and cancer chemoresistance thwart many of the promising therapeutics. We demonstrate a method that confronts both of these issues with the light-activated delivery of a Bcl-2 functional converting peptide, NuBCP-9, using hollow gold nanoshells. This approach has shown not only to increase the efficacy of the peptide 30-fold in vitro but also has shown to reduce paclitaxel resistant H460 lung xenograft tumor growth by 56. Read More

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http://dx.doi.org/10.1007/s10495-019-01531-1DOI Listing

Comprehensive investigation of pesticides in Brazilian surface water by high resolution mass spectrometry screening and gas chromatography-mass spectrometry quantitative analysis.

Sci Total Environ 2019 Feb 28;669:248-257. Epub 2019 Feb 28.

Instituto de Química, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500, CEP 91501-970 Porto Alegre, RS, Brazil. Electronic address:

In this work, a comprehensive investigation on the occurrence of pesticides in the Paraná 3 hydrographic basin of Paraná State, Brazil, was made by application of wide-scope screening based on ultra-high performance liquid chromatography (LC) and gas chromatography (GC) both coupled to quadrupole time-of-flight mass spectrometry (QTOF MS). The use of two complementary techniques, such as GC-QTOF MS and LC-QTOF MS, allowed screening a large number of compounds with different polarity and volatility. This screening approach was applied to 17 samples, enabling the detection of fifty-two pesticides and six metabolites. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.354DOI Listing
February 2019

Ideal cardiovascular health associated with fatty liver: Results from a multi-ethnic survey.

Atherosclerosis 2018 Nov 8;284:129-135. Epub 2018 Nov 8.

Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland.

Background And Aims: Little is known about the role of liver enzymes as predictors of non-liver-related morbidity and mortality. The ideal cardiovascular health (CVH) score proposed by the American Heart Association (AHA) can be used to predict mortality and morbidity. We investigated the association of the CVH score with liver enzymes and the risk of non-alcoholic fatty liver disease (NAFLD) among US adults. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.11.012DOI Listing
November 2018

Associations of serum CRP levels with demographics, health behaviors, and risk of cancer among the Mexican American Mano A Mano Cohort.

Cancer Epidemiol 2019 Mar 14;60:1-7. Epub 2019 Mar 14.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

C-Reactive protein (CRP) is a well-known inflammatory marker, and elevated CRP levels has been reported to be associated with the risk of various cancers. To date, no study has investigated the association between elevated CRP and incidents of cancer among Mexican Americans. In the current prospective cohort study, we measured pre-diagnostic CRP levels in serum samples and evaluated their relationships with demographic characteristics and health behaviors associated with cancer risk among 2753 Mexican Americans selected from the Mano-A-Mano Mexican American Cohort Study. Read More

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http://dx.doi.org/10.1016/j.canep.2019.03.001DOI Listing

Predictors of timely opioid agonist treatment initiation among veterans with and without HIV.

Drug Alcohol Depend 2019 Mar 9;198:70-75. Epub 2019 Mar 9.

Center for Research on Health Care, Division of General Internal Medicine, University of Pittsburgh School of Medicine, UPMC Montefiore Hospital, Suite 933W, Pittsburgh, PA, 15213, USA; VA Pittsburgh Healthcare System, 4100 Allequippa St, Pittsburgh, PA, 15213, USA.

Background: Opioid use disorder (OUD) is prevalent among people with HIV (PWH). Opioid agonist therapy (OAT) is the most effective treatment for OUD and is associated with improved health outcomes, but is often not initiated. To inform clinical practice, we identified factors predictive of OAT initiation among patients with and without HIV. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2019.01.038DOI Listing

Metabolic Syndrome Associated with Increased Rates of Medical Complications Following Intracranial Tumor Resection.

World Neurosurg 2019 Mar 13. Epub 2019 Mar 13.

Division of Neurosurgery, University of Texas Medical Branch, Galveston, TX, USA.

Background: When diagnosed simultaneously, obesity, diabetes, and hypertension form a medical constellation called metabolic syndrome (MetS). The prevalence of MetS in Western cultures has been on a steady ascent and MetS has been associated with increased postoperative complications in multiple surgical settings.

Objective: In this study, we evaluate the relationship between MetS and the outcomes of craniotomy for supratentorial brain tumor. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.046DOI Listing

Full endoscopic discectomy, debridement, and drainage for high-risk patients with spondylodiscitis.

World Neurosurg 2019 Mar 13. Epub 2019 Mar 13.

Division of Neurosurgery, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan; School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; College of Nursing and Health Sciences, Dayeh University, Taiwan. Electronic address:

Objective: To evaluate the efficacy and clinical results of full endoscopic debridement and drainage (FEDD) for high-risk patients with spondylodiscitis.

Methods: A total of 14 patients who underwent FEDD at our institution between November 2015 and September 2017 were retrospectively reviewed. All patients had single-level infectious spondylodiscitis and were high-risk candidates for surgery. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.206DOI Listing

Workplace Harassment and Discrimination in Gynecology: Results of the AAGL Member Survey.

J Minim Invasive Gynecol 2019 Mar 13. Epub 2019 Mar 13.

Levine Cancer Institute at Atrium Health, Charlotte, NC.

Study Objective: To characterize workplace and sexual harassment and discrimination among physicians in gynecology.

Design: A beta-tested internet survey was distributed by email using the REDCap platform. All responses were anonymous. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.03.004DOI Listing

Superior Capsular Reconstruction for Massive Rotator Cuff Tear Leads to Significant Improvement in Range of Motion and Clinical Outcomes: A Systematic Review.

Arthroscopy 2019 Mar 13. Epub 2019 Mar 13.

Houston Methodist Orthopedic and Sports Medicine, Houston, Texas, U.S.A.. Electronic address:

Purpose: To determine if arthroscopic superior capsular reconstruction for massive irreparable rotator cuff tears results in statistically significant and clinically significant improvement in patient-reported outcomes and shoulder range of motion with low graft failure, complication, and reoperation rates.

Methods: A systematic review was registered with PROSPERO and performed using PRISMA guidelines. PubMed, SCOPUS, and Cochrane databases were searched. Read More

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http://dx.doi.org/10.1016/j.arthro.2018.10.129DOI Listing

Arthroscopic Superior Capsular Reconstruction for Massive, Irreparable Rotator Cuff Tears: A Systematic Review of Modern Literature.

Arthroscopy 2019 Mar 13. Epub 2019 Mar 13.

University of Pittsburgh Medical Center Center for Sports Medicine, Pittsburgh, Pennsylvania, U.S.A.. Electronic address:

Purpose: To systematically review and evaluate the efficacy and complication profile of superior capsular reconstruction (SCR) as a technique to address massive, irreparable rotator cuff tears (MIRCTs).

Methods: Searches of the Cochrane Database of Systematic Reviews, Embase, MEDLINE, PubMed, and conference abstracts of 4 major conferences identified clinical studies addressing SCR for MIRCTs. Two reviewers independently screened the titles, abstracts, and full texts, extracting data from eligible studies. Read More

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http://dx.doi.org/10.1016/j.arthro.2018.09.033DOI Listing

An oral health baseline of need at a predominantly African American Program of All-Inclusive Care for the Elderly (PACE): Opportunities for dental-nursing collaboration.

Geriatr Nurs 2019 Mar 14. Epub 2019 Mar 14.

University of Pennsylvania School of Nursing, 418 Curie Blvd, Philadelphia, PA 19104, United States.

This descriptive study sought to establish an oral health baseline of need for enrollees at a Program of All-Inclusive Care for the Elderly (PACE) and identify opportunities for nursing interventions. The Oral Health Assessment Tool (OHAT) was applied to a random sample of 120 enrollees, 64 of whom met inclusion criteria, agreed to participate to assess their oral health status, and were included in the analysis. The mean OHAT score was 4. Read More

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http://dx.doi.org/10.1016/j.gerinurse.2018.12.014DOI Listing

Modified frailty index is an effective risk-stratification tool for patients undergoing total shoulder arthroplasty.

J Shoulder Elbow Surg 2019 Mar 13. Epub 2019 Mar 13.

Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, GA, USA.

Background: Frailty, as quantified by the modified frailty index (mFI), has emerged as a promising method to identify patients at high risk of complications after surgery. Several studies have shown that frailty, as opposed to age, is more predictive of adverse surgical outcomes. We hypothesized that a 5-item mFI could be used to identify patients at elevated risk of complications after total shoulder arthroplasty (TSA). Read More

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http://dx.doi.org/10.1016/j.jse.2018.12.004DOI Listing

Routine monitoring for heparin-induced thrombocytopenia following lower limb arthroplasty: Is it necessary? A prospective study in a UK district general hospital.

Orthop Traumatol Surg Res 2019 Mar 13. Epub 2019 Mar 13.

York Hospital NHS Foundation Trust, Wiggington Road, York, YO31 8HE, United Kingdom.

Introduction: Heparin-induced thrombocytopenia (HIT) is a potentially life-threatening condition associated with heparin administration. Many orthopaedic units routinely prescribe low-molecular-weight heparins as thromboprophylaxis after hip and knee arthroplasty.

Hypothesis: We postulated that routine platelet monitoring following heparin administration is of no clinical benefit. Read More

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http://dx.doi.org/10.1016/j.otsr.2018.12.012DOI Listing

Toward patient-centered care and inclusive health-care governance: a review of patient empowerment in the UAE.

Public Health 2019 Mar 13;169:114-124. Epub 2019 Mar 13.

Mohammed Bin Rashid School of Government (MBRSG), Convention Tower, Level 7, P.O. Box 72229, Dubai, United Arab Emirates. Electronic address:

Objectives: The purpose of this article was twofold. We aimed to both clarify the multidimensional notion of patient empowerment (PE) and conduct a comprehensive survey of PE-related literature in the specific context of the United Arab Emirates (UAE).

Study Design: The study objectives were achieved by means of a two-phased systematic review of the literature on PE and associated dimensions. Read More

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http://dx.doi.org/10.1016/j.puhe.2019.01.017DOI Listing
March 2019
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Mitochondria in precision medicine; linking bioenergetics and metabolomics in platelets.

Redox Biol 2019 Mar 10;22:101165. Epub 2019 Mar 10.

Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, UK. Electronic address:

Mitochondria possess reserve bioenergetic capacity, supporting protection and resilience in the face of disease. Approaches are limited to understand factors that impact mitochondrial functional reserve in humans. We applied the mitochondrial stress test (MST) to platelets from healthy subjects and found correlations between energetic parameters and mitochondrial function. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101165DOI Listing

Validation of the Neogen ELISA Benzodiazepine Kit using Clonazepam as the Target Molecule for Blood and Urine.

J Anal Toxicol 2019 Mar 16. Epub 2019 Mar 16.

Marshall University Forensic Science, 1401 Forensic Science Drive, Huntington WV, USA.

This study demonstrates the validation of a semi-quantitative method for the rapid screening of whole blood and urine specimens using clonazepam as the target molecule for the Neogen® Benzodiazepine kit. Decision points were validated at 10.0 ng/mL for whole blood and 25. Read More

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http://dx.doi.org/10.1093/jat/bkz010DOI Listing

Epidemiology, control, and prevention of Newcastle disease in endemic regions: Latin America.

Trop Anim Health Prod 2019 Mar 15. Epub 2019 Mar 15.

Exotic and Emerging Avian Viral Disease Research Unit, Southeast Poultry Research Laboratory, United States National Poultry Research Center, USDA/ARS, Athens, GA, 30605, USA.

Newcastle disease (ND) infects wild birds and poultry species worldwide, severely impacting the economics of the poultry industry. ND is especially problematic in Latin America (Mexico, Colombia, Venezuela, and Peru) where it is either endemic or re-emerging. The disease is caused by infections with one of the different strains of virulent avian Newcastle disease virus (NDV), recently renamed Avian avulavirus 1. Read More

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http://dx.doi.org/10.1007/s11250-019-01843-zDOI Listing

Factors associated with willingness to provide biospecimens for genetics research among African American cancer survivors.

J Community Genet 2019 Mar 14. Epub 2019 Mar 14.

College of Medicine Alcohol Research Center, Howard University, Washington, DC, USA.

This study evaluated factors associated with willingness to provide biospecimens for cancer genetic research among African American cancer survivors. A total of 200 African American adults diagnosed with breast, colon, and/or prostate cancers completed a self-administered survey. Family history information, beliefs about cancer research, cancer genetics and disparities knowledge, willingness to provide a biospecimen, and demographics were obtained. Read More

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http://dx.doi.org/10.1007/s12687-019-00411-0DOI Listing

Comparing duloxetine and pregabalin for treatment of pain and depression in women with fibromyalgia: an open-label randomized clinical trial.

Daru 2019 Mar 14. Epub 2019 Mar 14.

Department of General Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Background: Duloxetine and pregabalin are among the most widely used medications in the treatment of patients with fibromyalgia syndrome (FM).

Objectives: To add to the very few lines of evidence that exist on the comparative safety and efficacy of these two medications.

Methods: In this open-label randomized clinical trial, outpatient women, who were diagnosed with FM based on American College of Rheumatology 2010 criteria, and had an age range of 18-65 years old were assigned to either duloxetine 30-60 mg or pregabalin 75-150 mg per day for 4 weeks. Read More

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http://dx.doi.org/10.1007/s40199-019-00257-4DOI Listing
March 2019
2 Reads

C677T and A1298C methylenetetrahydrofolate reductase polymorphisms and breast cancer susceptibility among Latinos: a meta-analysis.

Breast Cancer 2019 Mar 15. Epub 2019 Mar 15.

Departamento de Genética, Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, 13 Sur 2901 Col. Volcanes, C.P. 72420, Puebla, Pue, Mexico.

Background: Previous meta-analyses have shown an ethnic dependency of the C677T and the A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms, with no focus on the Latino population. For Latinos, many studies have examined these polymorphisms and breast cancer susceptibility, yielding no concise result. Therefore, we undertook this meta-analysis to determine the effect these polymorphisms have on breast cancer risk for Latinos. Read More

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http://dx.doi.org/10.1007/s12282-019-00961-8DOI Listing

Impact of fatty acid binding protein 5-deficiency on COPD exacerbations and cigarette smoke-induced inflammatory response to bacterial infection.

Clin Transl Med 2019 Mar 15;8(1). Epub 2019 Mar 15.

Department of Biomedical Research, National Jewish Health, 1400 Jackson St., Room K827, Denver, CO, 80206, USA.

Background: Although cigarette smoking (CS) is by far the most important risk factor of chronic obstructive pulmonary disease (COPD), repeated and sustained infections are clearly linked to disease pathogenesis and are responsible for acute inflammatory flares (i.e. COPD exacerbations). Read More

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http://dx.doi.org/10.1186/s40169-019-0227-8DOI Listing

2018 Cholesterol Guidelines: Key Topics in Primary Prevention.

Curr Atheroscler Rep 2019 Mar 16;21(5):17. Epub 2019 Mar 16.

Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.

Purpose Of Review: The 2018 American College of Cardiology (ACC) and American Heart Association (AHA) cholesterol guidelines are a comprehensive update providing recommendations for management of patients with high blood cholesterol based on the best available evidence. This review highlights key topics clinicians need to know for the primary prevention of atherosclerotic cardiovascular disease (ASCVD) based on the 2018 ACC/AHA cholesterol guidelines.

Recent Findings: The guidelines include a broad framework for risk estimation and management for primary prevention of ASCVD. Read More

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http://dx.doi.org/10.1007/s11883-019-0776-8DOI Listing

Development of disorder-specific normative data for growth in children with cerebral palsy.

Eur J Pediatr 2019 Mar 14. Epub 2019 Mar 14.

Faculty of Medicine and University Hospital Cologne, Department of Pediatrics, University of Cologne, Cologne, Germany.

The purpose of this study was to create growth-percentiles for Caucasian children with cerebral palsy (CP). The studied parameters were height and age. In a retrospective analysis, we converted measurements collected in our center to create disorder-specific percentiles of normative data. Read More

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http://dx.doi.org/10.1007/s00431-019-03360-5DOI Listing

Canine models of human amelogenesis imperfecta: identification of novel recessive ENAM and ACP4 variants.

Hum Genet 2019 Mar 15. Epub 2019 Mar 15.

Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.

Amelogenesis imperfecta (AI) refers to a genetically and clinically heterogeneous group of inherited disorders affecting the structure, composition, and quantity of tooth enamel. Both non-syndromic and syndromic forms of AI have been described and several genes affecting various aspects of the enamel physiology have been reported. Genetically modified murine models of various genes have provided insights into the complex regulation of proper amelogenesis. Read More

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http://dx.doi.org/10.1007/s00439-019-01997-8DOI Listing

Prevention and Management of Severe Obstetric Anal Sphincter Injuries (OASIs): a National Survey of Nurse- Midwives.

Int Urogynecol J 2019 Mar 15. Epub 2019 Mar 15.

Division of Reproductive Sciences, Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Introduction And Hypothesis: There are no data on midwives' knowledge and management of obstetric anal sphincter injuries (OASIs) in the USA. We performed a cross-sectional national survey characterizing OASI practice by certified nurse midwives (CNMs), hypothesizing that few midwives personally repair OASIs and that there are gaps in CNM OASI training/education.

Methods: We emailed a REDCap internet-based survey to 6909 American College of Nurse Midwives members (ACNM). Read More

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http://dx.doi.org/10.1007/s00192-019-03897-xDOI Listing

Reconstruction of the urethra with an anterior vaginal mucosal flap in female urethral stricture.

Int Urogynecol J 2019 Mar 15. Epub 2019 Mar 15.

Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction And Hypothesis: We present our single institution experience with urethral reconstruction by using anterior U-shaped vaginal flap in female patients with urethral stricture.

Methods: Retrospective analysis was performed from March 2014 to April 2018. Fourteen patients with retention or severe voiding dysfunction and failed conservative management were enrolled. Read More

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http://dx.doi.org/10.1007/s00192-019-03910-3DOI Listing

Epidemiology: Back to the Future.

Am J Epidemiol 2019 Mar 16. Epub 2019 Mar 16.

Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH.

In 2018 the Society for Epidemiologic Research (SER) and the its partner journal, the American Journal of Epidemiology (AJE), assembled a working group to develop a set of papers devoted to the "future of epidemiology". These 14 papers covered a wide range of topic areas and perspectives - from thoughts on our profession, teaching, methods, to critical areas of substantive research. The papers considered current challenges and future opportunities for research and education. Read More

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http://dx.doi.org/10.1093/aje/kwz045DOI Listing

Discussion of forest definitions and tree cover estimates for Haiti.

Proc Natl Acad Sci U S A 2019 Mar 15. Epub 2019 Mar 15.

Department of Geography and Sustainable Planning, Grand Valley State University, Allendale, MI 49401.

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http://dx.doi.org/10.1073/pnas.1901163116DOI Listing

Community Engagement and Equitable Policy: Promoting Resilience and Stability for Children in Immigrant Families in North Carolina.

N C Med J 2019 Mar-Apr;80(2):94-100

associate professor of pediatrics, University of South Carolina School of Medicine Greenville, Greenville, South Carolina; pediatrician, Prisma Health Children's Hospital-Upstate, Columbia, South Carolina; adjunct assistant professor of pediatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina

Immigrant families in North Carolina, despite multidimensional challenges in the context of national, state, and local policies, enrich our communities. Over the last 18 months, a small group of North Carolina Pediatric Society (NCPS) physicians with concerns about the health and emotional well-being of children in immigrant families have come together to address the challenges facing this vulnerable population. Our goal, as the newly formed NCPS Committee on Immigration, is to advance policy to support immigrant families in obtaining equitable health, educational, and economic opportunities in our state. Read More

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http://dx.doi.org/10.18043/ncm.80.2.94DOI Listing

Extensive circumferential partial-thickness sclerectomy in eyes with extreme nanophthalmos and spontaneous uveal effusion.

Br J Ophthalmol 2019 Mar 15. Epub 2019 Mar 15.

Ophthalmology, American University of Beirut, Beirut, Lebanon.

Aim: To describe an extensive scleral excision technique to treat uveal effusion in nanophthalmic eyes.

Methods: This prospective, interventional series of eight eyes of five consecutive patients with nanophthalmos underwent scleral window surgeries. Ninety per cent of the scleral thickness, extending from immediately behind the extraocular muscle insertions to the vortex veins for 3 and 1/4 quadrants, was removed. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313702DOI Listing

Outcomes and treatment strategies for autoimmunity and hyperinflammation in patients with RAG deficiency.

J Allergy Clin Immunol Pract 2019 Mar 12. Epub 2019 Mar 12.

Division of Allergy and Immunology, Massachusetts General Hospital for Children, Boston, MA, USA. Electronic address:

Background: While autoimmunity and hyperinflammation secondary to recombinase activating gene (RAG) deficiency have been associated with delayed diagnosis and even death, our current understanding is limited primarily to small case series.

Objective: Understand the frequency, severity, and treatment responsiveness of autoimmunity and hyperinflammation in RAG deficiency.

Methods: In reviewing the literature and our own database, we identified 85 patients with RAG deficiency, reported between 2001 and 2016, and compiled the largest case series to date of 63 patients with prominent autoimmune and/or hyperinflammatory pathology. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.038DOI Listing

Nutrition, Obesity and Cachexia in Patients with Heart Failure: A Consensus Statement from the HFSA Scientific Statements Committee.

J Card Fail 2019 Mar 12. Epub 2019 Mar 12.

Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Dietary guidance for patients with heart failure (HF) has traditionally focused on sodium and fluid intake restriction, but dietary quality is frequently poor in patients with HF and may contribute to morbidity and mortality. Restrictive dietary counselling can lead to inadequate intake of macronutrients and micronutrients by patients with HF, with the potential for deficiencies of calcium, magnesium, zinc, iron, thiamine, vitamins D, E, K, and folate. Although inadequate intake and low plasma levels of micronutrients have been associated with adverse clinical outcomes, evidence supporting therapeutic repletion is limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10719164183091
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http://dx.doi.org/10.1016/j.cardfail.2019.03.007DOI Listing
March 2019
1 Read

Prophylactic Versus Therapeutic Mastectomy: A Contemporary Analysis of the ACS-NSQIP Database.

Clin Breast Cancer 2019 Jan 31. Epub 2019 Jan 31.

Division of Surgical Oncology, Department of Surgery, University of Massachusetts, Worcester, MA. Electronic address:

Introduction: The objective of the study was to evaluate the morbidity, mortality, and postoperative outcomes associated with simple or subcutaneous mastectomy in the management of prophylactic versus therapeutic resection. In this study we aimed to assess if simple or subcutaneous mastectomy for prophylaxis affects perioperative outcomes compared with resection performed for biopsy proven malignancy.

Materials And Methods: The American College of Surgeons National Surgical Quality Improvement Program database was queried for subjects who underwent simple or subcutaneous mastectomy between 2007 and 2012. Read More

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http://dx.doi.org/10.1016/j.clbc.2019.01.008DOI Listing
January 2019

Teaching practicing surgeons what not to do: An analysis of instruction fluidity during a simulation-based continuing medical education course.

Surgery 2019 Mar 12. Epub 2019 Mar 12.

University of Wisconsin-Madison, School of Medicine and Public Health, Department of Surgery.

Background: Interest is growing in simulation-based continuing medical education courses for practicing surgeons. However, little research has explored the instruction employed during these courses. This study examines instruction practices used during an annual simulation-based continuing medical education course. Read More

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http://dx.doi.org/10.1016/j.surg.2019.01.016DOI Listing

Merkel cell carcinoma incidence, trends, and survival rates among adults aged ≥50 years from United States Cancer Statistics.

J Am Acad Dermatol 2019 Apr;80(4):1154-1156

Centers for Disease Control and Prevention, Division of Cancer Prevention and Control, Atlanta, Georgia.

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http://dx.doi.org/10.1016/j.jaad.2018.10.045DOI Listing

Impact of a preventive bundle to reduce surgical site infections in gynecologic oncology.

Gynecol Oncol 2019 Mar;152(3):480-485

Division of Gynecologic Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada. Electronic address:

Objective: To assess the impact of a surgical site infection (SSI) prevention bundle for Gynecologic Oncology patients at a large academic tertiary centre in Toronto, Canada.

Methods: A SSI prevention bundle was implemented in February 2017 including: preoperative chlorhexidine shower, prophylactic antibiotics, glycemic control, normothermia, and separate closing tray. Data were collected prospectively using the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) institutional data, and chart review of surgeries between January 2016 and September 2017 was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183121
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http://dx.doi.org/10.1016/j.ygyno.2018.09.008DOI Listing
March 2019
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Targeted composite value-based endpoints in platinum-sensitive recurrent ovarian cancer.

Gynecol Oncol 2019 Mar;152(3):445-451

Duke University Medical Center, Durham, NC, USA.

Objectives: FDA-approved treatments for platinum-sensitive recurrent ovarian cancer (PSROC) include bevacizumab and PARP inhibitors (PARPi); clinical decisions regarding therapy must be made prior to initiating chemotherapy. Using the American Society of Clinical Oncology (ASCO) and European Society of Medical Oncology (ESMO) value frameworks, we assessed relative values of concurrent/maintenance biologic therapies in PSROC.

Methods: Value scores were calculated for key maintenance therapies based on randomized controlled trials: bevacizumab (OCEANS, GOG 213); olaparib (Study 19, SOLO2); niraparib (NOVA); rucaparib (ARIEL3). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183144
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http://dx.doi.org/10.1016/j.ygyno.2018.11.028DOI Listing
March 2019
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Driving the precision medicine highway: community health workers and patient navigators.

J Transl Med 2019 Mar 15;17(1):85. Epub 2019 Mar 15.

Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona College of Medicine-Tucson, Tucson, AZ, 85721, USA.

The general public is currently bombarded with direct-to-consumer advertising, real time "medical" guidance through the internet, access to digital devices that capture health information, and science-based adds that promote foods, cosmetics, and dietary supplements. Unfortunately, much of this information relies on terminology and concepts not well-understood by consumers, particularly those with lower levels of health and genomic literacy. Such constraints align with the limitations of the American public to obtain and process the basic medical information needed to make appropriate healthcare decisions. Read More

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http://dx.doi.org/10.1186/s12967-019-1826-2DOI Listing

Association between tea and coffee consumption and brain cancer risk: an updated meta-analysis.

World J Surg Oncol 2019 Mar 15;17(1):51. Epub 2019 Mar 15.

Department of Neurology, Tianjin First Center Hospital, No. 24, Fukang Road, Nankai District, Tianjin, 300192, China.

Background: Previous studies had demonstrated some associations between coffee and tea consumption and brain cancer risk resulted in an inconsistent relationship. We therefore performed this study to further explore the association between them.

Method: By searching PubMed, Embase, and Web of Science, we retrieved up to 1 November 2018, 11 relevant literature of publications were collected by 2 people eventually. Read More

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http://dx.doi.org/10.1186/s12957-019-1591-yDOI Listing

Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis.

Acta Neuropathol Commun 2019 Mar 15;7(1):42. Epub 2019 Mar 15.

Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

Astroblastoma (AB) is a rare CNS tumor demonstrating abundant astroblastomatous pseudorosettes. Its molecular features have not been comprehensively studied and its status as a tumor entity is controversial. We analyzed a cohort of 27 histologically-defined ABs using DNA methylation profiling, copy number analysis, FISH and site-directed sequencing. Read More

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http://dx.doi.org/10.1186/s40478-019-0689-3DOI Listing

Increases in statin eligibility to reduce cardiovascular risk according to the 2013 ACC/AHA cholesterol guidelines in the Africa Middle East region: a sub-analysis of the Africa Middle East Cardiovascular Epidemiological (ACE) study.

BMC Cardiovasc Disord 2019 Mar 15;19(1):61. Epub 2019 Mar 15.

College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.

Background: With development of cholesterol management guidelines by the American College of Cardiology/American Heart Association (ACC/AHA), more individuals at risk of cardiovascular disease may be eligible for statin therapy. It is not known how this affects statin eligibility in the Africa and Middle East Region.

Methods: Data were used from the Africa Middle East Cardiovascular Epidemiological (ACE) study. Read More

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http://dx.doi.org/10.1186/s12872-019-1034-2DOI Listing

Constructing the Microbial Association Network from Large-Scale Time Series Data Using Granger Causality.

Genes (Basel) 2019 Mar 14;10(3). Epub 2019 Mar 14.

Department of Medicine, Stanford University School of Medicine, 269 Campus Dr., Stanford, CA 94305, USA.

The increasing availability of large-scale time series data allows the inference of microbial community dynamics by association network analysis. However, correlation-based association network analyses are noninformative of causal, mediating and time-dependent relationships between microbial community functional factors. To address this insufficiency, we introduced the Granger causality model to the analysis of a recent marine microbial time series dataset. Read More

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http://dx.doi.org/10.3390/genes10030216DOI Listing

Leveraging the Cardio-Protective and Anticancer Properties of Resveratrol in Cardio-Oncology.

Nutrients 2019 Mar 14;11(3). Epub 2019 Mar 14.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.

Cardio-oncology is a clinical/scientific discipline which aims to prevent and/or treat cardiovascular diseases in cancer patients. Although a large number of cancer treatments are known to cause cardiovascular toxicity, they are still widely used because they are highly effective. Unfortunately, therapeutic interventions to prevent and/or treat cancer treatment-induced cardiovascular toxicity have not been established yet. Read More

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http://dx.doi.org/10.3390/nu11030627DOI Listing

Obatoclax, a BH3 Mimetic, Enhances Cisplatin-Induced Apoptosis and Decreases the Clonogenicity of Muscle Invasive Bladder Cancer Cells via Mechanisms That Involve the Inhibition of Pro-Survival Molecules as Well as Cell Cycle Regulators.

Int J Mol Sci 2019 Mar 14;20(6). Epub 2019 Mar 14.

Department of Pharmaceutical & Biomedical Sciences, California Northstate University College of Pharmacy (CNUCOP), Elk Grove, CA 95757, USA.

Several studies by our group and others have determined that expression levels of Bcl-2 and/or Bcl-xL, pro-survival molecules which are associated with chemoresistance, are elevated in patients with muscle invasive bladder cancer (MI-BC). The goal of this study was to determine whether combining Obatoclax, a BH3 mimetic which inhibits pro-survival Bcl-2 family members, can improve responses to cisplatin chemotherapy, the standard of care treatment for MI-BC. Three MI-BC cell lines (T24, TCCSuP, 5637) were treated with Obatoclax alone or in combination with cisplatin and/or pre-miR-34a, a molecule which we have previously shown to inhibit MI-BC cell proliferation via decreasing Cdk6 expression. Read More

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http://dx.doi.org/10.3390/ijms20061285DOI Listing
March 2019
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Prevalence and genetic diversity of viral gastroenteritis viruses in children younger than 5 years of age in Guatemala, 2014-2015.

J Clin Virol 2019 Mar 9;114:6-11. Epub 2019 Mar 9.

Division of Viral Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address:

Background: Acute diarrhea is an important cause of morbidity and mortality in children and is associated with approximately 500,000 deaths/year globally. Rotavirus and norovirus are leading causes of acute diarrhea accounting for more than half of this burden.

Objective/study Design: To determine the prevalence and genotype distribution of acute diarrhea caused by rotavirus, norovirus, sapovirus and astrovirus among children <5 years of age at two departments in Guatemala from January 2014 to December 2015, we tested 471 stool specimens (202 samples from hospitalized children and 269 samples from children in ambulatory clinics) by real-time reverse transcription-PCR and genotyped positive samples. Read More

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http://dx.doi.org/10.1016/j.jcv.2019.03.006DOI Listing

Association of ideal cardiovascular health metrics with serum uric acid, inflammation and atherogenic index of plasma: A population-based survey.

Atherosclerosis 2018 Sep 15;284:44-49. Epub 2018 Sep 15.

Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland.

Background And Aims: We aimed to evaluate the link between inflammatory score [consisting of C-reactive protein (CRP) and white blood cells], serum uric acid (SUA) and atherogenic index of plasma (AIP) and the cardiovascular health (CVH) score.

Methods: We used the cross-sectional National Health and Nutrition Examination Survey database. Statistical analyses accounted for the survey design and sample weights. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219150183137
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http://dx.doi.org/10.1016/j.atherosclerosis.2018.09.016DOI Listing
September 2018
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