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    1025 results match your criteria American Journal of Clinical Dermatology[Journal]

    1 OF 21

    Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis.
    Am J Clin Dermatol 2017 Nov 2. Epub 2017 Nov 2.
    Department of Dermatology, Beilinson Hospital, Rabin Medical Center, 4941492, Petah Tikva, Israel.
    Background: Current systemic treatments for atopic dermatitis (AD) offer limited efficacy and are often restricted by safety concerns. Biologics may address the unmet need for improved AD therapeutics.

    Objective: The aim of this study was to evaluate the efficacy and safety of biologic agents in AD. Read More

    Choosing First-Line Biologic Treatment for Moderate-to-Severe Psoriasis: What Does the Evidence Say?
    Am J Clin Dermatol 2017 Oct 27. Epub 2017 Oct 27.
    Department of Dermatology, Kaiser Permanente Los Angeles Medical Center, 1515 North Vermont Ave, 5th Floor, Los Angeles, CA, 90027, USA.
    An advanced understanding of the pathogenesis of psoriasis has led to the development of multiple therapeutic options for moderate-to-severe psoriasis. Tumor necrosis factor inhibitors, ustekinumab, interleukin-17 inhibitors, and guselkumab (an interleukin-23 inhibitor recently approved for psoriasis) are commercially available biologic agents for psoriasis. Evidence from clinical trials provides pertinent information regarding the safety and efficacy of biologic agents for psoriasis, which should be integrated into clinical decision making. Read More

    Crisaborole Ointment 2%: A Review in Mild to Moderate Atopic Dermatitis.
    Am J Clin Dermatol 2017 Dec;18(6):837-843
    Springer, Private Bag 65901, Mairangi Bay, 0754, Auckland, New Zealand.
    Crisaborole ointment 2% (Eucrisa™) is a novel, anti-inflammatory inhibitor of phosphodiesterase 4 (PDE4) that is available in the USA for the topical treatment of mild to moderate atopic dermatitis in patients aged ≥ 2 years. In two short-term (28 days), identically designed, multicentre, phase III studies in this patient population, topical therapy with crisaborole ointment 2% reduced disease severity and pruritus severity compared with vehicle, with the effect established early and sustained over the course of treatment. Improvements in the other signs of atopic dermatitis (erythema, exudation, excoriation, induration/papulation, and lichenification) were also seen. Read More

    Vitamin D and the Skin: An Update for Dermatologists.
    Am J Clin Dermatol 2017 Oct 9. Epub 2017 Oct 9.
    Department of Dermatology, Hôpital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
    Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Read More

    A Practical Guide About Tattooing in Patients with Chronic Skin Disorders and Other Medical Conditions.
    Am J Clin Dermatol 2017 Oct 9. Epub 2017 Oct 9.
    Department of Dermatology, AZ Sint-Jan Brugge-Oostende AV, 8000, Brugge, Belgium.
    With tattoos becoming increasingly mainstream, dermatologists are more and more often consulted by patients who are considering getting an ornamental, cosmetic, or even a medical tattoo, and who subsequently ask for advice. This includes not only patients with chronic skin diseases such as psoriasis or atopic dermatitis but also patients with other medical conditions. This review first explores the reasons why patients may want to get a tattoo and aims to offer some key information to dermatologists on what they should know about tattooing and the main risks associated with this procedure. Read More

    Pharmacogenetics and Pharmacogenomics in Moderate-to-Severe Psoriasis.
    Am J Clin Dermatol 2017 Sep 18. Epub 2017 Sep 18.
    Dermatology Department, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria la Princesa (IIS-IP), Madrid, Spain.
    Pharmacogenetics is the study of variations in DNA sequence related to drug response. Moreover, the evolution of biotechnology and the sequencing of human DNA have allowed the creation of pharmacogenomics, a branch of genetics that analyzes human genes, the RNAs and proteins encoded by them, and the inter-and intra-individual variations in expression and function in relation to drug response. Pharmacogenetics and pharmacogenomics are being used to search for biomarkers that can predict response to systemic treatments, including those for moderate-to-severe psoriasis. Read More

    Acne Scars: How Do We Grade Them?
    Am J Clin Dermatol 2017 Sep 11. Epub 2017 Sep 11.
    Department of Dermatology, University of California, Davis, 3301 C Street, Suite 1400, Sacramento, CA, 95816, USA.
    Acne vulgaris is a chronic inflammatory skin disease that can lead to permanent scarring. Although grading scales exist for acne scarring, there are many limitations, and there is still a need for a well validated gold standard scale for use in clinical practice or research trials. An objective measure of scar severity should be a component of global acne severity evaluations. Read More

    Small Molecule Inhibitors of the Hedgehog Pathway in the Treatment of Basal Cell Carcinoma of the Skin.
    Am J Clin Dermatol 2017 Sep 8. Epub 2017 Sep 8.
    Department of Dermatology, University of Colorado School of Medicine, Mail Stop F703, 1665, North Aurora Court, Aurora, CO, 80045, USA.
    Basal cell carcinoma (BCC) is the most common type of skin cancer, with rising incidence rates primarily attributed to an aging population and ultraviolet radiation exposure. While the majority of BCCs are localized and respond to standard therapies, a very small minority of these tumors become locally destructive or metastasize. These advanced BCCs may not be amenable to localized treatment with surgery and/or radiation therapy. Read More

    Teledermatology: A Review and Update.
    Am J Clin Dermatol 2017 Sep 4. Epub 2017 Sep 4.
    Department of Dermatology, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA.
    Telemedicine is slowly transforming the way in which healthcare is delivered and has the potential to improve access to subspecialty expertise, reduce healthcare costs, and improve the overall quality of care. While many subspecialty fields within medicine today have either experimented with or begun to implement telemedicine platforms to enable remote consultation and care, dermatology is particularly suited for this care system as skin disorders are uniquely visible to the human eye. Through teledermatology, diagnostic images of skin disorders with accompanying clinical histories can be remotely reviewed by teledermatologists by any number of modalities, such as photographic clinical images or live video teleconferencing. Read More

    Combinatorial Therapies in Melanoma: MAPK Inhibitors and Beyond.
    Am J Clin Dermatol 2017 Aug 31. Epub 2017 Aug 31.
    Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA.
    Melanoma is the most aggressive of the skin cancers, with historically high rates of morbidity and mortality due to its resistance to traditional cytotoxic therapies. Recently, however, breakthroughs in new therapies have dramatically changed clinical outcomes of this disease. These advances emerged from an improved understanding of tumor oncogenesis and the interacting tumor microenvironment. Read More

    Topical Corticosteroid Concerns Among Parents of Children with Psoriasis versus Atopic Dermatitis: A French Multicenter Cross-Sectional Study.
    Am J Clin Dermatol 2017 Aug 28. Epub 2017 Aug 28.
    Dermatology Department, University Hospital of Nancy, Batiment P Canton, 6 allée du Morvan, 54500, Vandoeuvre les Nancy, France.
    Background: Atopic dermatitis (AD) and psoriasis are chronic inflammatory cutaneous disorders for which the gold standard treatment is topical corticosteroids. Although fears about topical corticosteroids are known to be a primary cause of poor therapeutic adherence in AD, this has not been evaluated in psoriasis. TOPICOP is a helpful and easy-to-use tool for the evaluation of topical corticosteroid concerns (TCC). Read More

    Inherited Nonsyndromic Ichthyoses: An Update on Pathophysiology, Diagnosis and Treatment.
    Am J Clin Dermatol 2017 Aug 16. Epub 2017 Aug 16.
    Department of Medical Sciences, Dermatology, Uppsala University, Uppsala, Sweden.
    Hereditary ichthyoses are due to mutations on one or both alleles of more than 30 different genes, mainly expressed in the upper epidermis. Syndromic as well as nonsyndromic forms of ichthyosis exist. Irrespective of etiology, virtually all types of ichthyosis exhibit a defective epidermal barrier that constitutes the driving force for hyperkeratosis, skin scaling, and inflammation. Read More

    Evaluation of the Relationship between Alopecia Areata and Viral Antigen Exposure.
    Am J Clin Dermatol 2017 Aug 11. Epub 2017 Aug 11.
    Rochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY, 14621, USA.
    Background: Alopecia areata (AA) is an autoimmune disease characterized by non-scarring alopecia with T-cell infiltration at the affected hair follicle.

    Objective: Our aim was to study the potential link between hepatitis B virus (HBV) antigen exposure and AA.

    Methods: Two pediatric patients with AA following hepatitis B vaccination were identified in a general dermatology clinic. Read More

    Laser and Light Treatments for Hair Reduction in Fitzpatrick Skin Types IV-VI: A Comprehensive Review of the Literature.
    Am J Clin Dermatol 2017 Aug 8. Epub 2017 Aug 8.
    Department of Dermatology and Cutaneous Surgery, University of Miami Hospital, 1475 NW 12th Ave. Suite 2175, Miami, FL, 33136, USA.
    Unwanted facial and body hair presents as a common finding in many patients, such as females with hirsutism. With advances in laser and light technology, a clinically significant reduction in hair can be achieved in patients with light skin. However, in patients with darker skin, Fitzpatrick skin types (FST) IV-VI, the higher melanin content of the skin interferes with the proposed mechanism of laser-induced selective photothermolysis, which is to target the melanin in the hair follicle to cause permanent destruction of hair bulge stem cells. Read More

    Natural Oils for Skin-Barrier Repair: Ancient Compounds Now Backed by Modern Science.
    Am J Clin Dermatol 2017 Jul 13. Epub 2017 Jul 13.
    Department of Medicine, Dermatology Division, Arizona Cancer Center, University of Arizona, PO BOX 245024, 1515 N. Campbell Ave., Building #222, Levy Bldg., 1906E, Tucson, AZ, 85724-5024, USA.
    Natural plant oils are commonly used as topical therapy worldwide. They are usually easily accessible and are relatively inexpensive options for skin care. Many natural oils possess specific compounds with antimicrobial, antioxidant, anti-inflammatory, and anti-itch properties, making them attractive alternative and complementary treatments for xerotic and inflammatory dermatoses associated with skin-barrier disruption. Read More

    Birt-Hogg-Dubé Syndrome: A Review of Dermatological Manifestations and Other Symptoms.
    Am J Clin Dermatol 2017 Jul 10. Epub 2017 Jul 10.
    Department of Dermatology, University of California San Diego, 8899 University Center Lane, Suite 350, San Diego, CA, 92122, USA.
    Birt-Hogg-Dubé syndrome (BHD) is an autosomal dominant genodermatosis with malignant potential characterized by cutaneous and extracutaneous stigmata. Aberrations in the folliculin (FLCN) gene, which is located on chromosome 17, have been discovered in individuals with this condition. Over 150 unique mutations have been identified in BHD. Read More

    Cryotherapy for Intra- and Perianal High-Grade Squamous Intraepithelial Lesions in HIV-Positive Men who have Sex with Men.
    Am J Clin Dermatol 2017 Jul 10. Epub 2017 Jul 10.
    Center for Infection and Immunology Amsterdam (CINIMA), Academic Medical Center, 1105 AZ, Amsterdam, The Netherlands.
    Background: Available treatment options for anal high-grade squamous intraepithelial lesions (HSIL) in HIV-positive men who have sex with men (MSM) are limited by low response rates and frequent recurrences. Cryotherapy is an established therapeutic option for several pre-malignant skin disorders.

    Methods: This retrospective, non-randomized study included HIV-positive MSM who received intra- and/or perianal HSIL cryotherapy treatment between 30 December 2008 and 23 April 2015. Read More

    Probiotics, Prebiotics, and Synbiotics for the Treatment and Prevention of Adult Dermatological Diseases.
    Am J Clin Dermatol 2017 Dec;18(6):721-732
    Department of Dermatology, UC Davis, 3301 C Street, Suite 1400, Sacramento, CA, 95816, USA.
    Background: Probiotic, prebiotic, and synbiotic supplementation is becoming more prevalent nowadays. Clinical studies have demonstrated some of the medical benefits of probiotics, prebiotics, and synbiotics within dermatology but an evidence-based review of their effects in adults is needed.

    Objective: The aim of this study was to identify evidence for the use of supplementation with probiotics, prebiotics, or synbiotics for the prevention and treatment of dermatological diseases in adults. Read More

    Cutaneous Graft-Versus-Host Disease: Diagnosis and Treatment.
    Am J Clin Dermatol 2017 Jun 27. Epub 2017 Jun 27.
    Department of Dermatology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
    Graft-versus-host disease (GVHD) is an immunological reaction and a frequent complication following allogeneic hematopoietic stem cell transplantation. It is associated with high mortality rates and may have a significant negative impact on the patient's quality of life, particularly in the chronic-stage setting. Many different organs can be involved, which leads to a wide range of clinical manifestations. Read More

    Diagnosis and Treatment of Rosacea Fulminans: A Comprehensive Review.
    Am J Clin Dermatol 2017 Jun 27. Epub 2017 Jun 27.
    Department of Dermatology, University of California San Francisco, 1701 Divisadero Street, 3rd Floor, San Francisco, CA, 94115, USA.
    Rosacea fulminans is a rare inflammatory condition of the central face marked by the abrupt onset of erythematous coalescing papules, pustules, nodules, and draining sinuses. Due to infrequent reporting in the literature, the pathophysiology, classification, and nomenclature of this condition remain controversial. This comprehensive review evaluated a total of 135 cases of rosacea fulminans for clinical and histopathologic features and reported treatment strategies. Read More

    Drug-Induced Pyoderma Gangrenosum: A Review.
    Am J Clin Dermatol 2017 Jun 17. Epub 2017 Jun 17.
    York Dermatology Centre, Toronto, ON, Canada.
    Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that may be caused by an adverse drug reaction. We discuss the clinical presentation and outcomes of 52 cases of drug-induced PG reported to date in the literature. We conducted our literature search for case reports of drug-induced PG using keywords on PubMed and Medical Subject Heading (MeSH) terms on MEDLINE and EMBASE. Read More

    Systematic Review of Diagnostic Criteria Used in Atopic Dermatitis Randomized Controlled Trials.
    Am J Clin Dermatol 2017 Jun 17. Epub 2017 Jun 17.
    Department of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, 676 N. Saint Clair St, Suite 1600, Chicago, IL, 60611, USA.
    Background: Numerous diagnostic criteria for atopic dermatitis are used in clinical trials, which may limit comparison of results.

    Objective: We sought to determine the most commonly used atopic dermatitis diagnostic criteria in randomized controlled trials internationally.

    Methods: We performed a systematic review of randomized controlled trials with a pharmacological intervention from 2007 to 2016. Read More

    Apremilast: A Novel Oral Treatment for Psoriasis and Psoriatic Arthritis.
    Am J Clin Dermatol 2017 Jun 8. Epub 2017 Jun 8.
    Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
    Psoriasis is a chronic immune-mediated disease associated with several co-morbidities and negative impacts on a patient's quality of life. Despite the advances in biologic therapy, there are still unmet needs in the treatment of psoriasis, as current treatments are limited in terms of long-term efficacy, tolerability, safety, route of administration, and cost. Apremilast is an oral, small-molecule phosphodiesterase 4 inhibitor that works intracellularly by blocking the degradation of cyclic adenosine 3',5'-monophosphate, resulting in increased intracellular cyclic adenosine 3',5'-monophosphate levels in phosphodiesterase 4-expressing cells. Read More

    Clinical Signs, Pathophysiology and Management of Cutaneous Side Effects of Anti-Tumor Necrosis Factor Agents.
    Am J Clin Dermatol 2017 Dec;18(6):771-787
    Department of Dermatology, Division of Dermato-Immunology, KU Leuven, University Hospital Sint-Rafaël, Kapucijnenvoer 33, 3000, Leuven, Belgium.
    Approximately one in four patients treated with anti-TNF agents (infliximab, etanercept, adalimumab, certolizumab, and golimumab) develops cutaneous adverse events, typically months to years after the initiation of treatment, with xerosis cutis, eczema (often psoriasiform), psoriasis, palmoplantar pustulosis, cutaneous infections, alopecia, and skin cancer being the most frequently encountered. The typical skin lesion of anti-tumor necrosis factor (TNF)-treated patients is orange-red psoriasiform eczema affecting the flexures, genitalia, scalp, or face, with high susceptibility to bacterial superinfection with Staphylococcus aureus. When adequate dermatological treatment is administered to patients with skin lesions receiving anti-TNF treatment, the discontinuation of anti-TNF agents is only rarely required. Read More

    Comment on: "Assessing Pruritus in Hidradenitis Suppurativa: A Cross-Sectional Study".
    Am J Clin Dermatol 2017 Jun 8. Epub 2017 Jun 8.
    Department of Dermatology, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), C/ Maestro Alonso s/n, 03010, Alicante, Spain.

    Vitiligo: An Update on Pathophysiology and Treatment Options.
    Am J Clin Dermatol 2017 Dec;18(6):733-744
    Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.
    The pathophysiology of vitiligo is becoming increasingly clarified. In non-segmental vitiligo, early factors include activation of innate immunity, inflammasome activation, oxidative stress, and loss of melanocyte adhesion. Nonetheless, the main mechanism leading to non-segmental vitiligo involves an immune-mediated destruction of melanocytes. Read More

    Alopecia Areata of the Beard: A Review of the Literature.
    Am J Clin Dermatol 2017 Dec;18(6):789-796
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave., Miami, FL, 33136, USA.
    Alopecia areata (AA) is a T-cell mediated autoimmune disorder in which inflammatory cells attack the hair follicle, resulting in round, well-circumscribed patches of noncicatricial hair loss in normal appearing skin. AA affecting the beard area is well known and is referred to as AA of the beard (BAA) or AA barbae when involvement is limited exclusively to the beard. BAA has been documented in a select number of studies. Read More

    Pediatric Psoriasis.
    Am J Clin Dermatol 2017 Dec;18(6):797-811
    Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal.
    Psoriasis is a chronic inflammatory systemic disease associated with an important physical and physiological burden. It primarily affects the skin, but it is associated with several serious medical co-morbidities. One third of total psoriatic cases have their onset during the pediatric age, although some of them may not be diagnosed until the patient reaches adulthood. Read More

    MEK Inhibitors in the Treatment of Metastatic Melanoma and Solid Tumors.
    Am J Clin Dermatol 2017 Dec;18(6):745-754
    Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, Istituto Nazionale Tumori Fondazione "G. Pascale", Via Mariano Semmola, 80131, Naples, Italy.
    The mitogen-activated protein kinase (MAPK) cascade is an intracellular signaling pathway involved in the regulation of cellular proliferation and the survival of tumor cells. Several different mutations, involving BRAF or NRAS, exert an oncogenic effect by activating the MAPK pathway, resulting in an increase in cellular proliferation. These mutations have become targets for new therapeutic strategies in melanoma and other cancers. Read More

    Association Between Inflammatory Skin Disease and Cardiovascular and Cerebrovascular Co-Morbidities in US Adults: Analysis of Nationwide Inpatient Sample Data.
    Am J Clin Dermatol 2017 Dec;18(6):813-823
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N. St. Clair St., Chicago, IL, 60611, USA.
    Background: Psoriasis, atopic dermatitis or eczema (AD-E), pemphigus, bullous pemphigoid (BP), and hidradenitis are chronic inflammatory skin disorders associated with systemic immune activation, considerable symptom burden, stigma, functional disturbances, and mental health symptoms. All of these might increase cardiovascular risk.

    Objective: The objective of this study was to determine whether these inflammatory skin diseases are associated with increased cardiovascular/cerebrovascular risk and/or disease. Read More

    Sunscreens: An Update.
    Am J Clin Dermatol 2017 May 16. Epub 2017 May 16.
    Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.
    Sunscreens have been widely used by the general public for their photoprotective properties, including prevention of photocarcinogenesis and photoaging and management of photodermatoses. It is important to emphasize to consumers the necessity of broad-spectrum protection, with coverage of both ultraviolet A (320-400 nm) and ultraviolet B (290-320 nm) radiation. This review discusses the benefits of sunscreen, different ultraviolet filters, sunscreen regulations and controversies, the importance of broad-spectrum protection, issues of photostability and formulation, and patient education and compliance. Read More

    Diagnosing Allergic Contact Dermatitis Through Elimination, Perception, Detection and Deduction.
    Am J Clin Dermatol 2017 May 15. Epub 2017 May 15.
    Department of Cutaneous Allergy, St. John's Institute of Dermatology, Guy's Hospital, King's College, London, UK.
    Several authors have commented upon the skills of detection required in making a diagnosis of allergic contact dermatitis. Here, we emphasise the search for clues in a systematic manner. We describe four stages as part of a systematic method for diagnosing allergic contact dermatitis. Read More

    The Role of Micronutrients in Alopecia Areata: A Review.
    Am J Clin Dermatol 2017 May 15. Epub 2017 May 15.
    Department of Dermatology, Warren Alpert Medical School, Brown University, 339 Eddy Street, Providence, RI, 02903, USA.
    Alopecia areata (AA) is a common, non-scarring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Read More

    Onychotillomania: Diagnosis and Management.
    Am J Clin Dermatol 2017 Dec;18(6):763-770
    Department of Dermatology, Weill Cornell Medicine, 1305 York Avenue, New York, NY, 10021, USA.
    Onychotillomania, defined as self-induced trauma to the nail unit, either by picking or pulling at the nails, affects 0.9% of the population. It may lead to severe irreversible nail dystrophy, melanonychia, or infections. Read More

    Oral Ulcers in Juvenile-Onset Systemic Lupus Erythematosus: A Review of the Literature.
    Am J Clin Dermatol 2017 Dec;18(6):755-762
    Center of Excellence in Immunology and Immune-mediated Disease, Faculty of Medicine, Chulalongkorn University, Rama 4 Road, Pathumwan, Bangkok, 10330, Thailand.
    Oral ulcers are the most common mucosal sign in juvenile-onset systemic lupus erythematosus (JSLE). The ulcers are one of the key clinical features; however, the terminology of oral ulcers, especially in JSLE patients, is often vague and ill-defined. In fact, there are several clinical manifestations of oral ulcers in JSLE, and some lesions occur when the disease is active, indicating that early management of the disease should be started. Read More

    Discordance Between Physician- and Patient-Reported Disease Severity in Adults with Atopic Dermatitis: A US Cross-Sectional Survey.
    Am J Clin Dermatol 2017 Dec;18(6):825-835
    Sanofi, Bridgewater, NJ, USA.
    Background: There is limited understanding of severity rating of atopic dermatitis in clinical practice.

    Objectives: To evaluate the agreement between physician- and patient-rated severity of atopic dermatitis.

    Methods: Data were collected from the 2014 Adelphi US Atopic Dermatitis Disease Specific Programme, a cross-sectional survey of physicians and their patients with a history of moderate-to-severe atopic dermatitis; patients voluntarily completed a questionnaire. Read More

    Psoriasis, Depression, and Inflammatory Overlap: A Review.
    Am J Clin Dermatol 2017 Apr 21. Epub 2017 Apr 21.
    Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1071, USA.
    Psoriasis has an enormous impact on patients' lives and is frequently associated with depression. Depression in psoriasis may be attributed, at least in part, to elevated proinflammatory cytokines rather than the psychosocial impact of psoriasis itself. Biologics that target inflammatory cytokines treat the clinical manifestations of psoriasis, but may also play a role in reducing associated depression. Read More

    Rationale for New Checkpoint Inhibitor Combinations in Melanoma Therapy.
    Am J Clin Dermatol 2017 Apr 21. Epub 2017 Apr 21.
    Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
    The use of monoclonal antibodies that block immunologic checkpoints, which mediate adaptive immune resistance, has revolutionized the treatment of metastatic melanoma patients. Specifically, targeting single immune suppressive molecules such as cytotoxic T lymphocyte-associated protein 4 (CTLA-4), or programmed cell death protein 1 (PD-1) expressed on T cells or its primary ligand, programmed cell death ligand 1 (PD-L1), resulted in pronounced clinical benefit for a subset of melanoma patients. Although single-agent immune checkpoint inhibitor therapy has demonstrated promising clinical activity in metastatic melanoma patients, there is still a significant proportion of patients who show primary resistance to these therapies. Read More

    Assessing Pruritus in Hidradenitis Suppurativa: A Cross-Sectional Study.
    Am J Clin Dermatol 2017 Apr 20. Epub 2017 Apr 20.
    Department of Dermatology, Erasmus University Medical Center, Burgemeester s' Jacobplein 51, 3015 CA, Rotterdam, The Netherlands.
    Background: Pruritus is still a forgotten aspect of hidradenitis suppurativa (HS) and, to date, has never been adequately studied.

    Objective: The aim of this study was to determine the prevalence, and explore the characteristics, of pruritus in a well-defined cohort of HS patients.

    Setting: An academic hospital-based cross-sectional study in The Netherlands. Read More

    Increasing Frequency of Seborrheic Keratosis Diagnoses as a Favorable Consequence of Teledermatology-Based Skin Cancer Screening: A Cross-sectional Study of 34,553 Patients.
    Am J Clin Dermatol 2017 Apr 10. Epub 2017 Apr 10.
    Chief of the Medical and Surgical Dermatology Unit, HUVM Teledermatology Network, Hospital Universitario Virgen Macarena, Avda. Dr. Fedriani s/n, 41009, Seville, Spain.
    Background: Screening of skin cancer by teledermatology (TD) has improved the early detection of skin cancer by enhancing access to skin cancer clinics.

    Objective: We sought to analyze how TD-based skin cancer screening has changed the frequency of consultations for benign lesions.

    Patients And Methods: A cross-sectional study including teleconsultations received during a 7-year period was conducted to analyze and compare the trendlines of each lesion type over the study period. Read More

    A Unique Clinicopathological Manifestation of Fungal Infection: A Case Series of Deep Dermatophytosis in Immunosuppressed Patients.
    Am J Clin Dermatol 2017 Apr 8. Epub 2017 Apr 8.
    Department of Dermatology, Rabin Medical Center - Beilinson Hospital, 39 Jabotinski St., Petach Tikva, 4941492, Israel.
    Background: Dermatophytes are the most common cause of superficial fungal infections in humans. Deep dermatophytosis, however, is rare, described to date only in isolated case reports, usually in the setting of systemic immunosuppression.

    Objective: To present the 15-year experience of a tertiary dermato-mycology clinic with the diagnosis and treatment of deep dermatophytosis. Read More

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