1,213 results match your criteria American Journal of Clinical Dermatology[Journal]


Vitiligo and Melanoma-Associated Vitiligo: Understanding Their Similarities and Differences.

Am J Clin Dermatol 2020 May 28. Epub 2020 May 28.

Department of Dermatology, Keck School of Medicine, University of Southern California, 830 South Flower Street, Suite 100, Los Angeles, CA, 90017, USA.

Background: There has been a significant increase in the number and efficacy of therapies for advanced melanoma. Immunotherapies, such as anti-cytotoxic T-lymphocyte antigen-4 and programmed cell death-1 inhibitors, have improved the prognosis for patients with advanced melanoma. While spontaneous melanoma-associated vitiligo is a known phenomenon, the occurrence of melanoma-associated vitiligo following melanoma therapy is now recognized to associate with favorable outcomes. Read More

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http://dx.doi.org/10.1007/s40257-020-00524-0DOI Listing

Topical Minocycline Foam 4%: A Review in Acne Vulgaris.

Authors:
Julia Paik

Am J Clin Dermatol 2020 May 28. Epub 2020 May 28.

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Topical minocycline foam 4% (Amzeeq™) is approved in the USA for the treatment of inflammatory lesions of non-nodular, moderate to severe acne vulgaris (acne) in patients aged ≥ 9 years. It was developed to minimize systemic minocycline absorption and toxicity, and its high lipid content allows efficient drug movement through sebum and into affected sites. The favorable in vitro resistance profile of oral minocycline seen in Cutibacterium acnes (C. Read More

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http://dx.doi.org/10.1007/s40257-020-00523-1DOI Listing

Fabric Selection in Atopic Dermatitis: An Evidence-Based Review.

Am J Clin Dermatol 2020 May 21. Epub 2020 May 21.

Eczema and Skin Barrier Research Program, Dermatology Division, Department of Medicine, University of Arizona, 7165 N Pima Canyon Drive, Tucson, AZ, 85718, USA.

Background: Clothing fabrics interact closely with the skin to shape our cutaneous microenvironment. Cotton and silk have been traditionally recommended for patients with atopic dermatitis because of reported patient comfort. New synthetic fabrics combine anti-microbial, anti-inflammatory, moisture-wicking, and soothing properties that may augment conventional management strategies in atopic patients. Read More

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http://dx.doi.org/10.1007/s40257-020-00516-0DOI Listing

Treatment Goals in Psoriasis: Which Outcomes Matter Most?

Am J Clin Dermatol 2020 May 18. Epub 2020 May 18.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1071, USA.

Psoriasis is a chronic immune-mediated inflammatory disease that predominantly affects the skin and joints. Its detrimental effects on the physical, psychosocial, and emotional well-being of patients leads to a significant reduction in quality of life (QoL). The goals of treatment focus on decreasing disease severity and improving QoL for patients; accomplishing these goals requires physicians to understand both the full impact of the disease on a patient's life and the outcomes that matter most to patients. Read More

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http://dx.doi.org/10.1007/s40257-020-00521-3DOI Listing

Dermatologic Sequelae Associated with Radiation Therapy.

Am J Clin Dermatol 2020 May 14. Epub 2020 May 14.

Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Radiation therapy is a mainstay for the treatment of primary malignancies and metastatic disease and is associated with several dermatological adverse events that are underreported in the literature. The objective of this paper was to review the literature regarding cutaneous manifestations associated with radiation therapy in order to promote awareness of the cutaneous radiation therapy-associated adverse effects. This extensive literature review was performed using the Pubmed and Embase databases. Read More

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http://dx.doi.org/10.1007/s40257-020-00519-xDOI Listing

Eosinophilic Dermatoses: Recognition and Management.

Am J Clin Dermatol 2020 May 11. Epub 2020 May 11.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Eosinophilic dermatoses encompass a broad spectrum of diseases of different etiologies hallmarked by eosinophilic infiltration of the skin and/or mucous membranes, with or without associated blood eosinophilia. The wide range of dermatological manifestations of this spectrum, including nodules and plaques, pustules, blisters, ulcers, and urticarial lesions, is reflected in a non-univocal classification system. We identified six groups of eosinophilic dermatoses based on the predominant anatomic level of involvement: (1) epidermal; (2) of the dermal-epidermal junction; (3) dermal; (4) of the hypodermis and muscle fascia; (5) of the pilosebaceous unit; and (6) vascular/perivascular. Read More

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http://dx.doi.org/10.1007/s40257-020-00520-4DOI Listing

A Review of Noninvasive Techniques for Skin Cancer Detection in Dermatology.

Am J Clin Dermatol 2020 May 7. Epub 2020 May 7.

Cockerell Dermatopathology, 2110 Research Row, Suite 100, Dallas, TX, 72535, USA.

As a result of increasing melanoma incidence and challenges with clinical and histopathologic evaluation of pigmented lesions, noninvasive techniques to assist in the assessment of skin lesions are highly sought after. This review discusses the methods, benefits, and limitations of adhesive patch biopsy, electrical impedance spectroscopy (EIS), multispectral imaging, high-frequency ultrasonography (HFUS), optical coherence tomography (OCT), and reflectance confocal microscopy (RCM) in the detection of skin cancer. Adhesive patch biopsy provides improved sensitivity and specificity for the detection of melanoma without a trade-off of higher sensitivity for lower specificity seen in other diagnostic tools to aid in skin cancer detection, including EIS and multispectral imaging. Read More

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http://dx.doi.org/10.1007/s40257-020-00517-zDOI Listing

New and Emerging Biologics for Atopic Dermatitis.

Am J Clin Dermatol 2020 Apr 22. Epub 2020 Apr 22.

Department of Dermatology, Oregon Health and Science University, 3303 SW Bond Ave, Portland, OR, 97225, USA.

Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by complex pathophysiology involving both skin barrier dysfunction and aberrant type 2 inflammation/immune responses. AD can be a debilitating condition that drastically impairs quality of life, especially in patients with moderate-to-severe disease. Currently, topical therapies such as corticosteroids and non-steroidal immunomodulatory therapy provide limited efficacy for patients with moderate-to-severe AD; limitations include inadequate response, cutaneous toxicity from overuse, and poor tolerance due to stinging and burning. Read More

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http://dx.doi.org/10.1007/s40257-020-00515-1DOI Listing

Managing Cutaneous Immune-Mediated Diseases During the COVID-19 Pandemic.

Am J Clin Dermatol 2020 Apr 10. Epub 2020 Apr 10.

Department of Dermatology, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.

Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has spread rapidly worldwide and has been shown to have a wide spectrum of severity. COVID-19 has become a public health emergency of relevant international concern, and it was declared a pandemic by the World Health Organization on 11 March, 2020. Read More

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http://dx.doi.org/10.1007/s40257-020-00514-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147535PMC

Safety, Effectiveness, and Pharmacokinetics of Crisaborole in Infants Aged 3 to < 24 Months with Mild-to-Moderate Atopic Dermatitis: A Phase IV Open-Label Study (CrisADe CARE 1).

Am J Clin Dermatol 2020 Apr;21(2):275-284

Global Clinical Development, Pfizer Inc, Collegeville, PA, USA.

Background: Crisaborole ointment, 2%, is a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis (AD).

Objectives: The aim of this study was to evaluate the safety, effectiveness, and pharmacokinetics (PK) of crisaborole in infants aged 3 to < 24 months with mild-to-moderate AD in an open-label study.

Methods: Infants (3 to < 24 months) with Investigator's Static Global Assessment (ISGA) of mild (2) or moderate (3) and percentage of treatable body surface area (%BSA) ≥ 5 received crisaborole twice daily for 28 days; a cohort with moderate AD per ISGA and %BSA ≥ 35 were included in a PK analysis. Read More

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http://dx.doi.org/10.1007/s40257-020-00510-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125059PMC

Malignancy Rates in Brodalumab Clinical Studies for Psoriasis.

Am J Clin Dermatol 2020 Mar 23. Epub 2020 Mar 23.

Ortho Dermatologics, Bridgewater, NJ, USA.

Background: Brodalumab is a fully human anti-interleukin-17 receptor A monoclonal antibody efficacious for the treatment of adults with moderate-to-severe plaque psoriasis.

Objective: This study summarizes malignancy rates in psoriasis clinical studies of brodalumab.

Methods: Data were pooled from one phase II study and three large, multicenter, phase III randomized studies of brodalumab for the treatment of psoriasis, including two studies with randomization to brodalumab, ustekinumab, or placebo. Read More

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http://dx.doi.org/10.1007/s40257-020-00512-4DOI Listing

A Review Comparing International Guidelines for the Management of Bullous Pemphigoid, Pemphigoid Gestationis, Mucous Membrane Pemphigoid, and Epidermolysis Bullosa Acquisita.

Am J Clin Dermatol 2020 Mar 16. Epub 2020 Mar 16.

Department of Dermatology, University of Illinois at Chicago, 808 S. Wood St, RM377, Chicago, IL, 60612, USA.

Autoimmune blistering disease management can be challenging as treatment modalities vary greatly and no single standard of care exists. We consolidated the recommendations of international management guidelines in order to provide optimal management suggestions to physicians. A comprehensive literature search in PubMed/MEDLINE for published blistering disease management guidelines and consensus statements was conducted in November 2019. Read More

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http://dx.doi.org/10.1007/s40257-020-00513-3DOI Listing

Oral Spironolactone for Acne Vulgaris in Adult Females: An Update of the Literature.

Am J Clin Dermatol 2020 Apr;21(2):303-305

Hull York Medical School, Allam Medical Building, University of Hull, Hull, HU6 7RX, UK.

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http://dx.doi.org/10.1007/s40257-020-00511-5DOI Listing

Long-Term Outcomes in BRAF-Mutated Melanoma Treated with Combined Targeted Therapy or Immune Checkpoint Blockade: Are We Approaching a True Cure?

Am J Clin Dermatol 2020 Mar 2. Epub 2020 Mar 2.

Department of Dermatology, University Hospital Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany.

Approximately 50% of all melanomas harbor an activating BRAF mutation. In patients suffering from an advanced melanoma with such a somatic alteration, combined targeted therapy with a BRAF and MEK inhibitor can be applied to significantly increase the survival probability. Nevertheless, resistance mechanisms, as well as negative predictive biomarkers (elevated lactate dehydrogenase levels, high number of metastatic organ disease sites, brain metastasis), remain a major problem in treating melanoma patients. Read More

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http://dx.doi.org/10.1007/s40257-020-00509-zDOI Listing

Optimizing Isotretinoin Treatment of Acne: Update on Current Recommendations for Monitoring, Dosing, Safety, Adverse Effects, Compliance, and Outcomes.

Authors:
Megan N Landis

Am J Clin Dermatol 2020 Feb 27. Epub 2020 Feb 27.

Department of Medicine (Dermatology), University of Louisville School of Medicine, Louisville, KY, USA.

Acne vulgaris is the most common skin disease treated by dermatologists. It can be severe and result in permanent scars. Isotretinoin is the most effective treatment for acne and has the potential for long-term clearance. Read More

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http://dx.doi.org/10.1007/s40257-020-00508-0DOI Listing
February 2020

Dermatomyositis: An Update on Diagnosis and Treatment.

Am J Clin Dermatol 2020 Feb 24. Epub 2020 Feb 24.

Autoimmune Skin Disease Program, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA.

Dermatomyositis is a rare inflammatory disease with characteristic cutaneous findings and varying amounts of systemic involvement. Patients may present with skin disease alone, have concomitant muscle disease, or have extracutaneous manifestations such as pulmonary disease or an associated malignancy. Given such diverse presentations, dermatomyositis is both a diagnostic and therapeutic challenge. Read More

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http://dx.doi.org/10.1007/s40257-020-00502-6DOI Listing
February 2020

Baseline Characteristics from UNITE: An Observational, International, Multicentre Registry to Evaluate Hidradenitis Suppurativa (Acne Inversa) in Clinical Practice.

Am J Clin Dermatol 2020 Feb 19. Epub 2020 Feb 19.

Harvard Medical School and Beth Israel Deaconess Hospital, Boston, MA, USA.

Background: Hidradenitis suppurativa (HS), also known as acne inversa, is a recurring, painful, chronic, and sometimes disfiguring inflammatory skin disease.

Objectives: Our objective was to report the baseline clinical characteristics, natural history, and associated outcomes of patients with HS from the ongoing, prospective, non-interventional UNITE registry that is collecting data regarding the natural history and associated outcomes of HS.

Methods: Patients with inflammatory HS lesions were enrolled, including adolescents (aged 12 to < 18 years) and adults (aged ≥ 18 years). Read More

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http://dx.doi.org/10.1007/s40257-020-00504-4DOI Listing
February 2020

Safety and Effectiveness of Anti-Tumor Necrosis Factor-Alpha Biosimilar Agents in the Treatment of Psoriasis.

Am J Clin Dermatol 2020 Feb 11. Epub 2020 Feb 11.

Dermatology Research and Education Foundation, 4950 Barranca Pkwy, Suite 307, Irvine, CA, 92604, USA.

Biologic drugs have revolutionized the treatment of psoriasis and other chronic inflammatory diseases. In recent years, many tumor necrosis factor-alpha 'biosimilar' agents have been developed. These biosimilars are similar in structure and function to their originator molecules, although they are not identical. Read More

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http://dx.doi.org/10.1007/s40257-020-00507-1DOI Listing
February 2020

When is it OK to Stop Anti-Programmed Death 1 Receptor (PD-1) Therapy in Metastatic Melanoma?

Am J Clin Dermatol 2020 Feb 5. Epub 2020 Feb 5.

Center for Melanoma, Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston, MA, 02114, USA.

Systemic therapy for metastatic melanoma has been revolutionized over the past decade with the development of highly effective immune checkpoint inhibition, specifically anti-Programmed Death 1 receptor (PD-1) therapy. However, even though one-third of patients will have durable response to single-agent or combination therapy, the optimal duration of therapy is unknown. Identifying the optimal duration of therapy is important, as exposure to anti-PD-1 therapy increases the risk of developing immune-mediated toxicities that can have significant morbidity and are, at times, fatal. Read More

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http://dx.doi.org/10.1007/s40257-020-00506-2DOI Listing
February 2020

Palmoplantar Pustulosis: Recent Advances in Etiopathogenesis and Emerging Treatments.

Am J Clin Dermatol 2020 Feb 1. Epub 2020 Feb 1.

Department of Dermatology, Medical University of Warsaw, Koszykowa 82A, 02-008, Warsaw, Poland.

Palmoplantar pustulosis (PPP) is a chronic, recurrent skin disease belonging to the spectrum of psoriasis. It is characterized by an eruption of sterile pustules on the palms and soles. Recent studies in PPP have focused on genetic differences between pustular phenotypes and the role of the innate immunological system and the microbiome in the etiopathogenesis of the disease. Read More

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http://dx.doi.org/10.1007/s40257-020-00503-5DOI Listing
February 2020

Fixed Drug Eruptions: An Update, Emphasizing the Potentially Lethal Generalized Bullous Fixed Drug Eruption.

Am J Clin Dermatol 2020 Jan 30. Epub 2020 Jan 30.

Dermatology, Rutgers New Jersey Medical School, 185 South Orange Avenue, Medical Science Building H-576, Newark, NJ, 07103-2757, USA.

A fixed drug eruption (FDE) is a relatively common reaction associated with more than 100 medications. It is defined as a same-site recurrence with exposure to a particular medication. The primary approach and treatment for all types of FDEs are to identify and remove the causative agent, often accomplished by a thorough history of medication and other chemical exposures, and possibly prior episodes. Read More

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http://dx.doi.org/10.1007/s40257-020-00505-3DOI Listing
January 2020

Conjunctival Melanoma: Current Treatments and Future Options.

Am J Clin Dermatol 2020 Jan 21. Epub 2020 Jan 21.

Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA.

Conjunctival melanoma is a rare tumor of the conjunctival epithelium with a heterogenous clinical presentation and a propensity for regional and distant metastatic spread. Guidelines for the treatment of local conjunctival melanoma are well-established, but there are no standard efficacious therapies for metastatic disease. Given that conjunctival melanoma is genetically similar to cutaneous melanoma and mucosal melanomas, targeted therapies effective in the treatment of these diseases, such as BRAF inhibitors and KIT inhibitors, may be effective in the treatment of patients with metastatic conjunctival melanoma. Read More

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http://dx.doi.org/10.1007/s40257-019-00500-3DOI Listing
January 2020

Non-Classic Signs of Sézary Syndrome: A Review.

Am J Clin Dermatol 2020 Jan 17. Epub 2020 Jan 17.

Department of Dermatology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd. Unit 1452, Houston, TX, 77030, USA.

The majority of patients with Sézary syndrome (SS) present with classic symptoms of erythroderma, lymphadenopathy, and pruritus. However, there have been numerous reports of patients with SS who have non-classic signs. In this review, we report the less common clinical presentations of SS and discuss their relevant treatments. Read More

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http://dx.doi.org/10.1007/s40257-020-00501-7DOI Listing
January 2020

Investigator and Patient Global Assessment Measures for Psoriasis Clinical Trials: A Systematic Review on Measurement Properties from the International Dermatology Outcome Measures (IDEOM) Initiative.

Am J Clin Dermatol 2020 Jan 16. Epub 2020 Jan 16.

Department of Dermatology, Keck School of Medicine of the University of Southern California, 1975 Zonal Avenue, KAM 510, MC 9034, Los Angeles, CA, USA.

Background And Objective: The International Dermatology Outcome Measures (IDEOM) has defined a core set of domains to be measured in all psoriasis clinical trials. This set comprises the following domains: skin manifestations, psoriasis and psoriatic arthritis symptoms, health-related quality of life, investigator global, patient global, and treatment satisfaction. The next step is to define how to measure these domains. Read More

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http://dx.doi.org/10.1007/s40257-019-00496-wDOI Listing
January 2020
2.519 Impact Factor

Diabetic Foot Ulcers: Appraising Standard of Care and Reviewing New Trends in Management.

Am J Clin Dermatol 2020 Apr;21(2):255-264

Veterans Affairs Medical Center, Brooklyn, NY, USA.

Diabetic foot ulcers (DFU) are one of the most common diabetes complications and are associated with significant morbidity and mortality. Current DFU standard of care (SOC) involves four principles: (1) pressure relief, (2) debridement, (3) infection management, and (4) revascularization when indicated. Despite the current SOC, many DFU persist, warranting a new approach for the management of these complex wounds. Read More

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http://dx.doi.org/10.1007/s40257-019-00495-xDOI Listing

Psoriatic Disease in the US Latino Population: A Comprehensive Review.

Am J Clin Dermatol 2020 Apr;21(2):265-274

Department of Dermatology, Dermatology Clinical Research Center, University of California, Irvine, 843 Health Sciences Road, Hewitt Hall 1001, Irvine, CA, 92697, USA.

Current evidence suggests that there are notable differences in the severity of psoriasis between racial and ethnic groups. While the US Latino population is growing rapidly, there is little research on the various factors impacting disease severity in this minority population. This review evaluates the current evidence on psoriasis in Latinos within the US. Read More

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http://dx.doi.org/10.1007/s40257-019-00498-8DOI Listing

Laser and Light-Based Treatment Modalities for the Management of Hidradenitis Suppurativa.

Am J Clin Dermatol 2020 Apr;21(2):237-243

Department of Dermatology, Henry Ford Hospital, 3031 West Grand Blvd, Detroit, MI, 48202, USA.

Hidradenitis suppurativa is a chronic inflammatory skin disease characterized by inflammatory nodules, abscesses, and sinus tracts in intertriginous areas that has a significant impact on patient quality of life. Treatments range from topical, intralesional, systemic, and surgical. Furthermore, laser and light-based treatment options have become increasingly popular because of the limitations of adverse effects associated with systemic therapy and decreased down-time associated with laser and light therapy. Read More

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http://dx.doi.org/10.1007/s40257-019-00491-1DOI Listing

Rituximab: A Review in Pemphigus Vulgaris.

Authors:
James E Frampton

Am J Clin Dermatol 2020 Feb;21(1):149-156

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Rituximab (MabThera, Rituxan), a chimeric murine/human anti-CD20 monoclonal antibody administered by intravenous infusion, is indicated for the treatment of moderate to severe pemphigus vulgaris (PV), in combination with a tapering course of corticosteroids. Approval in the EU and USA was based on data for the subset of patients with newly-diagnosed, previously untreated PV participating in the randomized, controlled RITUX 3 study; rituximab plus short-course prednisone resulted in a > 3-fold higher rate of complete remission off prednisone therapy and a > 2-fold decrease in the rate of moderate/severe relapse compared with standard-dose prednisone in this patient subpopulation. In addition, rituximab plus short-term prednisone was steroid-sparing and resulted in fewer patients experiencing grade 3 or 4 corticosteroid-related adverse events compared with standard-dose prednisone. Read More

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http://dx.doi.org/10.1007/s40257-019-00497-9DOI Listing
February 2020

Sensitive Skin Syndrome: An Update.

Am J Clin Dermatol 2019 Dec 13. Epub 2019 Dec 13.

Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA.

Sensitive skin syndrome is a widely reported complaint but a diagnostic challenge because of its subjective symptoms and lack of clearly visible manifestations. Epidemiological studies have shown the prevalence of sensitive skin to be as high as 60-70% among women and 50-60% among men. Patients with this syndrome usually have unpleasant sensations when exposed to physical, thermal, or chemical stimuli that normally cause no provocation on healthy skin. Read More

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http://dx.doi.org/10.1007/s40257-019-00499-7DOI Listing
December 2019

Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris.

Am J Clin Dermatol 2020 Apr;21(2):245-254

Department of Dermatology, Massachusetts General Hospital, 50 Staniford Street, Suite 200, Boston, MA, 02114, USA.

Androgenetic alopecia (AGA) and acne vulgaris are two conditions commonly seen by dermatologists. Androgens and the androgen receptors play an essential role in the manifestation of both conditions, and some systemic therapies function by interfering in this pathway. The use of topical antiandrogen therapies has gained traction in recent years due to their potential efficacy in treating AGA and acne vulgaris, as well as their reduced adverse effects compared with systemic drugs. Read More

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http://dx.doi.org/10.1007/s40257-019-00493-zDOI Listing
April 2020
5 Reads

Clinically Meaningful Responses to Dupilumab in Adolescents with Uncontrolled Moderate-to-Severe Atopic Dermatitis: Post-hoc Analyses from a Randomized Clinical Trial.

Am J Clin Dermatol 2020 Feb;21(1):119-131

Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.

Background: Atopic dermatitis is a chronic inflammatory condition with substantial burden and limited treatment options for adolescents with moderate-to-severe disease. Significantly more patients treated with dupilumab vs. placebo achieved Investigator's Global Assessment 0/1 at week 16. Read More

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http://dx.doi.org/10.1007/s40257-019-00478-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989562PMC
February 2020

Neurological Cancer is a Risk Factor for Bullous Pemphigoid: 11-Year Population-Based Cohort Study.

Am J Clin Dermatol 2019 Dec 9. Epub 2019 Dec 9.

Department of Dermatology, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei, 11217, Taiwan.

Background: There is evidence suggesting an association between bullous pemphigoid (BP) and a range of neurological diseases. Whether neurological cancer is a risk factor for BP remains unknown.

Objective: The aim of the study was to investigate the risk of subsequent BP among patients with neurological cancer. Read More

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http://dx.doi.org/10.1007/s40257-019-00494-yDOI Listing
December 2019

Generalized Pustular Psoriasis: Clinical Management and Update on Autoinflammatory Aspects.

Am J Clin Dermatol 2020 Apr;21(2):227-236

Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Generalized pustular psoriasis (GPP) is a chronic, systemic inflammatory disease accompanied by high fever and general malaise. Diffuse erythema and swelling of the extremities occur, with multiple sterile pustules all over the body in GPP patients. GPP often relapses over the lifetime and can be life-threatening. Read More

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http://dx.doi.org/10.1007/s40257-019-00492-0DOI Listing

Melasma Treatment: An Evidence-Based Review.

Am J Clin Dermatol 2020 Apr;21(2):173-225

Department of Dermatology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9190, USA.

Background: Melasma is an acquired, chronic pigmentary disorder predominantly affecting women. It may significantly affect quality of life and self-esteem due to its disfiguring appearance. Multiple treatments for melasma are available, with mixed results. Read More

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http://dx.doi.org/10.1007/s40257-019-00488-wDOI Listing

Ixekizumab Effectiveness and Safety in the Treatment of Moderate-to-Severe Plaque Psoriasis: A Multicenter, Retrospective Observational Study.

Am J Clin Dermatol 2019 Nov 30. Epub 2019 Nov 30.

Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, 80131, Naples, Italy.

Background: Ixekizumab (anti-IL-17A) is a biological agent used for the treatment of moderate-to-severe psoriasis. Real-life data on the effectiveness and safety of ixekizumab are currently scarce.

Objective: The objective of this study was to evaluate the effectiveness and safety of ixekizumab in a cohort of psoriatic and psoriatic arthritis patients. Read More

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http://dx.doi.org/10.1007/s40257-019-00490-2DOI Listing
November 2019

Malignant Melanoma of the Vulva and Vagina: A US Population-Based Study of 1863 Patients.

Am J Clin Dermatol 2020 Apr;21(2):285-295

Division of Gynecologic Oncology, Department of Surgical Oncology, University Health Network, Toronto, ON, Canada.

Background: Vulvar melanoma (VuM) and vaginal melanoma (VaM) represent a unique subgroup of malignant melanomas with important differences in biology and treatment.

Objective: The objective of this study was to describe the epidemiology and prognosis of VuM and VaM in a large representative cohort.

Methods: Women with invasive VuM or VaM were identified from the Surveillance, Epidemiology and End Results-18 population representing 27. Read More

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http://dx.doi.org/10.1007/s40257-019-00487-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125071PMC

Updates on Botulinum Neurotoxins in Dermatology.

Am J Clin Dermatol 2020 Apr;21(2):157-162

University of Toronto, 2075 Bayview Ave M1 700, Toronto, ON, M4N 3M5, Canada.

Being the most popular non-surgical cosmetic procedure, botulinum neurotoxin (BoNT) injections are increasingly of interest to all cosmetic practitioners across the globe. This article serves to update readers on the new botulinum toxins that are currently in development or close to market in the USA and Canada, including daxibotulinumtoxin A, prabotulinumtoxin A, letibotulinumtoxin A, and botulinum toxin E. Despite having relatively similar characteristics and equivalent clinical efficacies, these neurotoxins manifest a multitude of unique potential advantages that will be explored in this review, including but not limited to a longer duration of action, the absence of animal-derived components or human albumin, and a rapid onset with short duration of action. Read More

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http://dx.doi.org/10.1007/s40257-019-00482-2DOI Listing

Effects of Zinc Supplementation on Inflammatory Skin Diseases: A Systematic Review of the Clinical Evidence.

Am J Clin Dermatol 2020 Feb;21(1):21-39

Department of Dermatology, University of California-Davis, 3301 C Street, Suite 1400, Sacramento, CA, 95816, USA.

Background: Zinc has been used in patients with acne vulgaris for its anti-inflammatory effects; however, it is unclear if zinc supplementation is also beneficial in other inflammatory skin conditions.

Objective: The objective of this article was to determine the effect of zinc supplementation on inflammatory dermatologic conditions.

Data Sources: We searched the Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, and Ovid with no time limit up to 29 May, 2019. Read More

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http://dx.doi.org/10.1007/s40257-019-00484-0DOI Listing
February 2020
4 Reads
2.519 Impact Factor

Herpes Zoster Presentation, Management, and Prevention: A Modern Case-Based Review.

Am J Clin Dermatol 2020 Feb;21(1):97-107

Department of Dermatology, Geisinger Health System-Scenery Park, 200 Scenery Dr, 56-02, State College, PA, 16801, USA.

Herpes zoster (HZ) is a common cutaneous entity with protean clinical presentations, management options, complication rates, and prevention strategies, all of which are rife with dogma. During an inpatient consultation for HZ, have you ever been approached by a frantic staff or family member, worried that a pregnant, elderly, or infant contact will be 'infected' if they get too close? Have your patients ever asked you about their risk of having HZ twice, or claimed that they have frequent 'recurrences'? In what timeline should antiviral therapy be employed? Is there evidence for prednisone or gabapentin in acute HZ treatment? Who should be vaccinated against HZ and what are the benefits and risks? In case-based form, these and other complex but common scenarios will be examined using clinical and viral mechanistic clues, along with updated treatment and prevention guidelines, to provide a modern HZ case management compendium, comprehensive of the diverse age and health populations now presenting with this condition. Read More

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http://dx.doi.org/10.1007/s40257-019-00483-1DOI Listing
February 2020

Drug-Induced Intracranial Hypertension: A Systematic Review and Critical Assessment of Drug-Induced Causes.

Am J Clin Dermatol 2020 Apr;21(2):163-172

Division of Dermatology, University of Ottawa, Ottawa, ON, Canada.

Background: Idiopathic intracranial hypertension (IIH) is a condition with increased intracranial pressure of unknown etiology. Its presenting symptoms include persistent headache, pulsatile tinnitus, and visual obscuration. It tends to occur in obese women of childbearing age, and its greatest risk is irreversible loss of vision. Read More

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http://dx.doi.org/10.1007/s40257-019-00485-zDOI Listing

Atopic Dermatitis and Celiac Disease: A Cross-Sectional Study of 116,816 Patients.

Am J Clin Dermatol 2020 Feb;21(1):133-138

Clalit Health Services, Tel Aviv, Israel.

Background: Both atopic dermatitis and celiac disease are often accompanied by other immune-mediated disorders.

Objective: The objective of this study was to evaluate the potential association between atopic dermatitis and celiac disease in a broad community-based population.

Methods: A cross-sectional observational design was used. Read More

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http://dx.doi.org/10.1007/s40257-019-00474-2DOI Listing
February 2020

Female Androgenetic Alopecia: An Update on Diagnosis and Management.

Am J Clin Dermatol 2020 Feb;21(1):69-84

Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, V. Massarenti 1, 40138, Bologna, Italy.

Female androgenetic alopecia (FAGA) is a common cause of non-scarring alopecia in women. The onset may be at any age following puberty and the frequency increases with age. Clinically, it shows a diffuse hair thinning over the central scalp, while the frontal hairline is usually retained. Read More

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http://dx.doi.org/10.1007/s40257-019-00479-xDOI Listing
February 2020
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Twenty Clinically Pertinent Factors/Observations for Percutaneous Absorption in Humans.

Am J Clin Dermatol 2020 Feb;21(1):85-95

Department of Dermatology, UCSF School of Medicine, N461 2340 Sutter Street, San Francisco, CA, 94115, USA.

At least 20 clinically relevant factors affect percutaneous absorption of drugs and chemicals: relevant physico-chemical properties, vehicle/formulation, drug exposure conditions (dose, duration, surface area, exposure frequency), skin appendages (hair follicles, glands) as sub-anatomical pathways, skin application sites (regional variation in penetration), population variability (premature, infants, and aged), skin surface conditions (hydration, temperature, pH), skin health and integrity (trauma, skin diseases), substantivity and binding to different skin components, systemic distribution and systemic toxicity, stratum corneum exfoliation, washing-off and washing-in, rubbing/massaging, transfer to others (human to human and hard surface to human), volatility, metabolic biotransformation/cutaneous metabolism, photochemical transformation and photosensitivity, excretion pharmacokinetics, lateral spread, and chemical method of determining percutaneous absorption. Read More

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http://dx.doi.org/10.1007/s40257-019-00480-4DOI Listing
February 2020
1 Read
2.519 Impact Factor

Impact of Clinical Specialty Setting and Geographic Regions on Disease Management in Patients with Psoriatic Arthritis in the United States: A Multicenter Observational Study.

Am J Clin Dermatol 2019 Dec;20(6):873-880

US Dermatology Partners, Rockville, MD, USA.

Background: Information on the factors that influence treatment management decisions for psoriatic arthritis (PsA) is limited.

Objective: Our objective was to evaluate the impact of clinical specialty setting and geographic region on the management of patients with PsA in the USA.

Methods: LOOP was a multicenter, cross-sectional, observational study conducted across 44 sites in the USA. Read More

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http://dx.doi.org/10.1007/s40257-019-00470-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872709PMC
December 2019
1 Read

Biomarkers Predictive of Survival and Response to Immune Checkpoint Inhibitors in Melanoma.

Am J Clin Dermatol 2020 Feb;21(1):1-11

Department of Medicine, Columbia University Irving Medical Center, 630 West 168th Street, P&S 9-428, New York, NY, 10032, USA.

Immunotherapy has revolutionized the treatment of melanoma. Targeting of the immune checkpoints cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 has led to improved survival in a subset of patients. Unfortunately, the use of immune checkpoint inhibitors is associated with significant side effects and many patients do not respond to treatment. Read More

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http://dx.doi.org/10.1007/s40257-019-00475-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994371PMC
February 2020
1 Read
2.519 Impact Factor

Hailey-Hailey Disease: An Update Review with a Focus on Treatment Data.

Am J Clin Dermatol 2020 Feb;21(1):49-68

Veterans Affairs Medical Center Brooklyn, 800 Poly Place, Brooklyn, NY, 11209, USA.

Hailey-Hailey disease is a rare blistering dermatosis first described in 1939 by the brothers Howard and Hugh Hailey. Its incidence is estimated at 1/50,000. The inheritance is autosomal dominant with complete penetrance, but a variable expressivity in affected family members. Read More

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http://dx.doi.org/10.1007/s40257-019-00477-zDOI Listing
February 2020

Retrospective Case Series on Risk Factors, Diagnosis and Treatment of Pseudomonas aeruginosa Nail Infections.

Am J Clin Dermatol 2020 Apr;21(2):297-302

Department of Dermatology, Weill Cornell Medicine, 1305 York Avenue, New York, NY, 10021, USA.

Background: Pseudomonas aeruginosa is the most common pathogen causing bacterial nail infections, producing a classic blue-green pigment, known as chloronychia. Clinical examination and dermoscopic findings, as well as diagnosis and treatment, have not been well characterized.

Objective: The aim was to characterize the clinical and dermoscopic findings of P. Read More

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http://dx.doi.org/10.1007/s40257-019-00476-0DOI Listing
April 2020
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Comment on: "Association of Early Systemic Corticosteroid Therapy with Mortality in Patients with Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis: A Retrospective Cohort Study Using a Nationwide Claims Database".

Authors:
André Cerejeira

Am J Clin Dermatol 2019 10;20(5):739

Department of Dermatology and Venereology, Centro Hospitalar Universitário São João EPE, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.

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http://dx.doi.org/10.1007/s40257-019-00472-4DOI Listing
October 2019
3 Reads

Authors' Reply to Cerejeira: "Association of Early Systemic Corticosteroid Therapy with Mortality in Patients with Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis: A Retrospective Cohort Study Using a Nationwide Claims Database".

Am J Clin Dermatol 2019 10;20(5):741

Department of Clinical Epidemiology and Health Economics, School of Public Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1007/s40257-019-00473-3DOI Listing
October 2019
4 Reads