1,119 results match your criteria American Journal of Clinical Dermatology[Journal]


Immune Checkpoint Inhibitors for Treating Advanced Cutaneous Squamous Cell Carcinoma.

Am J Clin Dermatol 2019 Feb 8. Epub 2019 Feb 8.

Department of Dermatology, Stanford University School of Medicine, 450 Broadway Street, Mail Code 5334, Redwood City, CA, 94063, USA.

Cutaneous squamous cell carcinoma (CSCC) is one of the most common human malignancies, and the incidence is increasing with time. High mutational loads, known infiltration with lymphocytes, and programmed death (PD)-ligand 1 (PD-L1) expression suggest that immune checkpoint inhibitors, such as PD-1 inhibitors, may show utility in treating CSCC, similar to response see in other solid tumor types. Recently, the robust responsiveness of CSCCs to the PD-1 inhibitor cemiplimab was revealed in the results of a combined phase I/II clinical trial, with an overall response rate of 50% and a durable response exceeding 6 months in 57% of responders. Read More

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http://link.springer.com/10.1007/s40257-019-00426-w
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http://dx.doi.org/10.1007/s40257-019-00426-wDOI Listing
February 2019
2 Reads

KIT as an Oncogenic Driver in Melanoma: An Update on Clinical Development.

Am J Clin Dermatol 2019 Feb 1. Epub 2019 Feb 1.

Division of Hematology/Oncology, Department of Medicine, Columbia University Irving Medical Center and the Herbert Irving Comprehensive Cancer Center, New York, NY, USA.

Metastatic melanoma is a heterogenous disease that has served as a model for the development of both targeted therapy and immunotherapy. KIT-mutated melanoma represents a rare subset, most commonly arising from acral, mucosal, and chronically sun-damaged skin. Additionally, KIT alterations are enriched in the triple wild-type subtype of cutaneous melanoma. Read More

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http://link.springer.com/10.1007/s40257-018-0414-1
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http://dx.doi.org/10.1007/s40257-018-0414-1DOI Listing
February 2019
3 Reads

Trends in Utilization and Expenditure for Onychomycosis Treatments in the United States in 2013-2016.

Am J Clin Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Department of Dermatology, Preventive Medicine and Medical Social Sciences, Feinberg School of Medicine, Northwestern University, 676 N. St. Clair St., Suite 1600/Dermatology, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1007/s40257-019-00425-xDOI Listing
January 2019

Topical Retinoids in Acne Vulgaris: A Systematic Review.

Am J Clin Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157-1071, USA.

Background: Topical retinoids are a first-line treatment for acne vulgaris.

Objective: This systematic review aims to evaluate the efficacy, safety, and tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris.

Methods: A PubMed and Embase search was conducted using the search terms 'adapalene,' 'tretinoin,' 'tazarotene,' and 'acne vulgaris. Read More

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http://link.springer.com/10.1007/s40257-019-00423-z
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http://dx.doi.org/10.1007/s40257-019-00423-zDOI Listing
January 2019
2 Reads

Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment.

Am J Clin Dermatol 2019 Jan 19. Epub 2019 Jan 19.

Fredric Brandt Endowed Professor of Dermatology, Miller School of Medicine, University of Miami, Miami, FL, USA.

Frontal fibrosing alopecia (FFA), first described by Kossard in the early 1990s, is a form of primary lymphocytic cicatricial alopecia characterized by selective involvement of the frontotemporal hairline and eyebrows. Since the original description, an increasing number of cases have been reported worldwide and the clinical aspects of the disease have been better characterized. However, the pathogenesis is still unknown and several hypotheses have been made about possible triggering factors, including hormones, neurogenic inflammation, smoking, UV filters, and ingredients in leave-on facial products. Read More

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http://dx.doi.org/10.1007/s40257-019-00424-yDOI Listing
January 2019
7 Reads

Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS): How Far Have We Come?

Am J Clin Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, University of Toronto, Toronto, Canada.

Drug reaction with eosinophilia and systemic symptoms (DReSS), also known as drug-induced hypersensitivity syndrome (DiHS), is an uncommon severe adverse reaction to medications. It is important to recognize it as it is potentially fatal and can cause significant morbidity. From the first reports of drug reactions related to certain anticonvulsants characterized by fever, liver enzyme elevation, and skin changes, our continuously growing understanding of this entity has allowed us to describe its physiopathology and clinical features even further. Read More

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http://dx.doi.org/10.1007/s40257-018-00416-4DOI Listing
January 2019
2 Reads

Association Between Psoriasis and Dementia: A Population-Based Case-Control Study.

Am J Clin Dermatol 2019 Jan 16. Epub 2019 Jan 16.

Graduate Institute of Biomedical Informatics, College of Medicine Science and Technology, Taipei Medical University, 250 Wu-Hsing St., Taipei, 110, Taiwan.

Background: Dementia is a syndrome that involves the deterioration of several higher mental functions in advanced age, and psoriasis is an autoimmune disease characterized by skin plaque. Epidemiological studies have indicated an association between dementia and psoriasis; however, to date, no studies in Asia have reported this association.

Objective: This study used a population-based medical dataset to explore the association between previously diagnosed psoriasis and dementia in Taiwan. Read More

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http://link.springer.com/10.1007/s40257-018-00420-8
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January 2019
11 Reads

Acne, the Skin Microbiome, and Antibiotic Treatment.

Am J Clin Dermatol 2019 Jan 10. Epub 2019 Jan 10.

Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, 4339 CNSI, 570 Westwood Plaza, Building 114, Los Angeles, CA, 90095, USA.

Acne vulgaris is a chronic skin disorder involving hair follicles and sebaceous glands. Multiple factors contribute to the disease, including skin microbes. The skin microbiome in the follicle is composed of a diverse group of microorganisms. Read More

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http://link.springer.com/10.1007/s40257-018-00417-3
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January 2019
8 Reads

Neutrophilic Dermatoses Associated with Myeloid Malignancies.

Am J Clin Dermatol 2019 Jan 10. Epub 2019 Jan 10.

Assistance Publique-Hôpitaux de Paris, Département de Pathologie, Hôpital Saint-Louis, Paris, France.

Neutrophilic dermatoses (ND) are a group of conditions characterized by an aseptic accumulation of polymorphonuclear leukocytes in the skin. Occurrence of ND in association with myeloid malignancies, mainly myelodysplastic syndrome and myelogenous acute leukemia, is not rare and is often associated with a poor prognosis. Recent findings have improved understanding of the pathophysiology of myeloid malignancy-associated ND. Read More

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http://dx.doi.org/10.1007/s40257-018-00418-2DOI Listing
January 2019
5 Reads

Correction to: JAK Inhibitors for Atopic Dermatitis: An Update.

Am J Clin Dermatol 2019 Jan 10. Epub 2019 Jan 10.

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, 5 E. 98th Street, New York, NY, 10029, USA.

Page 7, Table 1, ASN002 row. The cell entry in column 4, "Manufacturer", which previously read. Read More

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http://dx.doi.org/10.1007/s40257-019-00421-1DOI Listing
January 2019
1 Read

No Increased Risks Associated with Propranolol Treatment for Infantile Hemangioma in Preterm Infants were Identified at 3 Years of Age.

Am J Clin Dermatol 2019 Jan 7. Epub 2019 Jan 7.

Department of Dermatology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, No. 56 Nanlishi Road, Beijing, 100045, China.

Background: Concerns have been raised that propranolol treatment of infantile hemangioma (IH) may be associated with increased risks of adverse effects and growth impairment in preterm infants due to their immature development.

Objective: This study aimed to find out whether treatment of IH with propranolol in preterm infants is associated with higher incidences of long-term adverse effects and growth impairment in comparison with term infants.

Methods: The clinical data of 55 preterm infants and 180 term infants with IH treated with oral propranolol for 6 months were retrospectively collected and analyzed. Read More

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http://dx.doi.org/10.1007/s40257-018-00419-1DOI Listing
January 2019
2 Reads
2.519 Impact Factor

Efficacy of Microneedling Versus Fractional Non-ablative Laser to Treat Striae Alba: A Randomized Study.

Am J Clin Dermatol 2019 Jan 7. Epub 2019 Jan 7.

Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

Background: Striae distensae (SD), an unsightly cutaneous condition characterized by epidermal atrophy, can affect the quality of life of women.

Objectives: The aim of our study was to compare the efficacy of a neodymium:yttrium-aluminum-perovskite 1340 nm non-ablative fractional laser (NAFL) and the microneedling (MN) technique to treat striae alba (SA).

Materials And Methods: NAFL and MN were used to treat striae on the longitudinally divided abdominal surface of 20 women classified as Fitzpatrick skin type III or IV (five sessions at monthly intervals). Read More

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http://link.springer.com/10.1007/s40257-018-0415-0
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January 2019
5 Reads

Off-Label Use of Topical Minoxidil in Alopecia: A Review.

Am J Clin Dermatol 2019 Jan 2. Epub 2019 Jan 2.

Department of Dermatology, Northwestern University, 676 N St Clair St, Suite 1600, Chicago, IL, 60611, USA.

Topical minoxidil is a well-known and often-utilized drug in dermatological practice for the treatment of alopecia. It was approved by the United States Food and Drug Administration for the treatment of androgenetic alopecia in 1988. Since its approval, minoxidil has been used off-label for the treatment of many other types of alopecia, with minimal formal evidence of efficacy. Read More

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http://link.springer.com/10.1007/s40257-018-0409-y
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http://dx.doi.org/10.1007/s40257-018-0409-yDOI Listing
January 2019
6 Reads

Cannabinoids: Potential Role in Inflammatory and Neoplastic Skin Diseases.

Am J Clin Dermatol 2018 Dec 12. Epub 2018 Dec 12.

George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

The endocannabinoid system is a complex and nearly ubiquitous network of endogenous ligands, enzymes, and receptors that can also be stimulated by exogenous compounds such as those derived from the marijuana plant, Cannabis sativa. Recent data have shown that the endocannabinoid system is fully functional in the skin and is responsible for maintaining many aspects of skin homeostasis, such as proliferation, differentiation, and release of inflammatory mediators. Because of its role in regulating these key processes, the endocannabinoid system has been studied for its modulating effects on both inflammatory disorders of the skin and skin cancer. Read More

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http://dx.doi.org/10.1007/s40257-018-0410-5DOI Listing
December 2018
1 Read

JAK Inhibitors for Atopic Dermatitis: An Update.

Am J Clin Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, 5 E. 98th Street, New York, NY, 10029, USA.

Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. AD is driven by barrier dysfunction and abnormal immune activation of T helper (Th) 2, Th22, and varying degrees of Th1 and Th17 among various subtypes. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) and spleen tyrosine kinase (SYK) pathways are involved in signaling of several AD-related cytokines, such as IFN-γ, IL-4, IL-13, IL-31, IL-33, IL-23, IL-22, and IL-17, mediating downstream inflammation and barrier alterations. Read More

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http://dx.doi.org/10.1007/s40257-018-0413-2DOI Listing
December 2018
3 Reads

Alternative Treatments for Atopic Dermatitis: An Update.

Am J Clin Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease in which management with topical anti-inflammatory agents during exacerbations remains the mainstay of treatment. With no cure in sight, a significant proportion of patients elect to incorporate complementary and alternative medicine (CAM) as an adjunct to conventional treatment. Many clinicians find it difficult to provide recommendations as the field covers an extensive number of very disparate therapies, with limited quality evidence to indicate efficacy. Read More

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http://dx.doi.org/10.1007/s40257-018-0412-3DOI Listing
December 2018
4 Reads

Efficacy and Safety of Brodalumab in Patients with Moderate-to-Severe Plaque Psoriasis and Skin of Color: Results from the Pooled AMAGINE-2/-3 Randomized Trials.

Am J Clin Dermatol 2018 Nov 23. Epub 2018 Nov 23.

Mount Sinai St. Luke's and Mount Sinai West, New York, NY, USA.

Background: Data on treatment outcomes in patients with psoriasis who have skin of color are limited. Brodalumab has shown efficacy in patients with moderate-to-severe plaque psoriasis.

Objective: Our objective was to evaluate the efficacy, safety, and health-related quality of life associated with brodalumab in patients with skin of color participating in two phase III, multicenter, randomized, double-blind, placebo- and active comparator-controlled studies (AMAGINE-2/-3). Read More

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http://dx.doi.org/10.1007/s40257-018-0408-zDOI Listing
November 2018
9 Reads

Guselkumab: A Review in Moderate to Severe Plaque Psoriasis.

Am J Clin Dermatol 2018 Dec;19(6):907-918

Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Guselkumab (Tremfya) is a human immunoglobulin G1 λ (IgG1λ) monoclonal antibody (mAb) that blocks the interleukin-23 (IL-23)-mediated signalling pathway and is the first in its class to be approved in adults with moderate to severe plaque psoriasis in several countries, including the USA and EU. In the VOYAGE trials, guselkumab was superior to placebo and to adalimumab at week 16 in terms of the proportion of patients achieving an Investigator Global Assessment (IGA) score of 0/1 and ≥ 90% improvement from baseline in Psoriasis Area and Severity index score (PASI 90 response), with benefits of guselkumab over adalimumab maintained at week 24. To date, the beneficial effects of guselkumab treatment in these trials were maintained for up to 2 years. Read More

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http://dx.doi.org/10.1007/s40257-018-0406-1DOI Listing
December 2018
14 Reads

Probiotic Supplementation for Prevention of Atopic Dermatitis in Infants and Children: A Systematic Review and Meta-analysis.

Am J Clin Dermatol 2018 Nov 21. Epub 2018 Nov 21.

Department of Gastroenterology, Yijishan Hospital of Wannan Medical College, Wuhu, 241001, Anhui, People's Republic of China.

Background: Probiotic supplementation in early life may be effective in preventing atopic dermatitis (AD); however, results regarding efficacy have been controversial.

Objective: The aim of our study was to investigate the effect of probiotic supplementation on the risk of AD.

Methods: We systematically searched PubMed, EBSCO, Embase and Web of Science databases up to 8 March 2018 for potentially relevant studies regarding probiotic supplementation and AD. Read More

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http://dx.doi.org/10.1007/s40257-018-0404-3DOI Listing
November 2018
13 Reads

A Practical Guide to Curing Onychomycosis: How to Maximize Cure at the Patient, Organism, Treatment, and Environmental Level.

Am J Clin Dermatol 2019 Feb;20(1):123-133

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Onychomycosis is a fungal nail infection caused by dermatophytes, non-dermatophyte molds, and yeasts. Treatment of this infection can be difficult, with relapse likely to occur within 2.5 years of cure. Read More

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http://dx.doi.org/10.1007/s40257-018-0403-4DOI Listing
February 2019
8 Reads

Antibody-Based Therapies for Cutaneous T-Cell Lymphoma.

Am J Clin Dermatol 2019 Feb;20(1):115-122

University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1452, Houston, TX, 77030-4009, USA.

Cutaneous T-cell lymphomas (CTCLs) are a group of non-Hodgkin's lymphomas that present in the skin. In early-stage disease, the course is generally chronic and indolent; however, in advanced stages of disease, therapies rarely provide long-lasting responses, and the only potential curative therapy is allogeneic hematopoietic stem-cell transplantation. This has led to the search for novel targeted therapies to better treat more advanced stages of CTCLs that cannot be controlled by typical treatment regimens. Read More

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http://link.springer.com/10.1007/s40257-018-0402-5
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http://dx.doi.org/10.1007/s40257-018-0402-5DOI Listing
February 2019
12 Reads

Rituximab and Omalizumab for the Treatment of Bullous Pemphigoid: A Systematic Review of the Literature.

Am J Clin Dermatol 2018 Nov 13. Epub 2018 Nov 13.

Department of Dermatology, Beilinson Hospital, Rabin Medical Center, Petah-Tikva, 49100, Israel.

Background: Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease worldwide. Systemic corticosteroids are considered the mainstay of therapy; however, they may cause significant adverse effects and treatment failures, so additional therapeutic modalities with better safety profiles are required. Rituximab and omalizumab are novel biologic agents administered in recent years for the treatment of BP, yet data regarding their use in the disease are limited. Read More

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http://dx.doi.org/10.1007/s40257-018-0401-6DOI Listing
November 2018
12 Reads

Improvement in Patient-Reported Outcomes (Dermatology Life Quality Index and the Psoriasis Symptoms and Signs Diary) with Guselkumab in Moderate-to-Severe Plaque Psoriasis: Results from the Phase III VOYAGE 1 and VOYAGE 2 Studies.

Am J Clin Dermatol 2019 Feb;20(1):155-164

K Papp Clinical Research and Probity Medical Research Inc., Waterloo, ON, Canada.

Background: Health-related quality of life (HRQoL) may be markedly impaired in patients with moderate-to-severe psoriasis.

Objectives: Our objectives were to compare improvements in Dermatology Life Quality Index (DLQI) and Psoriasis Symptoms and Signs Diary (PSSD) scores between patients receiving guselkumab compared with placebo or adalimumab and to correlate these improvements with skin clearance.

Methods: Pooled phase III VOYAGE 1 and VOYAGE 2 data were evaluated through week 24. Read More

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http://link.springer.com/10.1007/s40257-018-0396-z
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February 2019
11 Reads
2.520 Impact Factor

Topical Glycopyrronium Tosylate for the Treatment of Primary Axillary Hyperhidrosis: Patient-Reported Outcomes from the ATMOS-1 and ATMOS-2 Phase III Randomized Controlled Trials.

Am J Clin Dermatol 2019 Feb;20(1):135-145

Saint Louis University, St. Louis, MO, USA.

Background: Glycopyrronium tosylate (GT) is a topical anticholinergic approved in the USA for primary axillary hyperhidrosis in patients aged ≥ 9 years. GT was evaluated for primary axillary hyperhidrosis in replicate, randomized, double-blind, vehicle-controlled, phase III trials. GT reduced sweating severity and production versus vehicle and was generally well tolerated. Read More

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http://link.springer.com/10.1007/s40257-018-0395-0
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http://dx.doi.org/10.1007/s40257-018-0395-0DOI Listing
February 2019
14 Reads

Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.

Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39

Institut Universitaire du Cancer Toulouse - Oncopole, 1 avenue Irène Joliot-Curie, 31059, TOULOUSE Cedex 9, France.

Targeted therapies and immunotherapies are associated with a wide range of dermatologic adverse events (dAEs) resulting from common signaling pathways involved in malignant behavior and normal homeostatic functions of the epidermis and dermis. Dermatologic toxicities include damage to the skin, oral mucosa, hair, and nails. Acneiform rash is the most common dAE, observed in 25-85% of patients treated by epidermal growth factor receptor and mitogen-activated protein kinase kinase inhibitors. Read More

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http://link.springer.com/10.1007/s40257-018-0384-3
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http://dx.doi.org/10.1007/s40257-018-0384-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244569PMC
November 2018
14 Reads

Homeostasis in Topical Photoprotection: Getting the Spectral Balance Right.

Authors:
Fernando Stengel

Am J Clin Dermatol 2018 Nov;19(Suppl 1):40-44

Buenos Aires Skin, Avenida Cordoba 1184, 10 Piso. (1055), Ciudad Autónoma de Buenos Aires, Argentina.

The solar radiation range has harmful and beneficial effects. Sunscreens, which selectively block specific spectral regions, may potentially interfere with skin homeostasis. For instance, the ultraviolet (UV) B waveband produces erythema and DNA damage; simultaneously, it induces pre-vitamin D synthesis. Read More

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http://link.springer.com/10.1007/s40257-018-0369-2
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http://dx.doi.org/10.1007/s40257-018-0369-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244613PMC
November 2018
20 Reads

Noninvasive Imaging Tools in the Diagnosis and Treatment of Skin Cancers.

Am J Clin Dermatol 2018 Nov;19(Suppl 1):3-14

Hospital Provincial del Centenario de Rosario, Argentina, Diagnóstico Médico Oroño, Bv. Oroño 1515, 2000, Rosario, Argentina.

In the 1980s, the increasing incidence of skin cancers prompted the development of noninvasive medical devices to improve skin cancer diagnosis in daily dermatology practice. As a result of the development of these noninvasive techniques, diagnosis is now established earlier and with better accuracy. These advances are of great benefit to high-risk patients, who previously would have had to undergo several excisions. Read More

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http://link.springer.com/10.1007/s40257-018-0367-4
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http://dx.doi.org/10.1007/s40257-018-0367-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244601PMC
November 2018
18 Reads

Unusual Clinical Presentations of Malignant Melanoma: A Review of Clinical and Histologic Features with Special Emphasis on Dermatoscopic Findings.

Am J Clin Dermatol 2018 Nov;19(Suppl 1):15-23

Department of Dermatology, Universidad del Desarrollo, Clínica Alemana, Manquehue Norte 1410, Vitacura, Santiago, Chile.

This review presents the main challenges encountered when diagnosing unusual variants of malignant melanoma with the aim of raising awareness to allow application of the most appropriate treatment strategies. Although these melanomas are often rare, their misdiagnosis potentially jeopardizes patients' health and survival, and has medicolegal implications. The clinical and histologic presentations of melanoma vary greatly, and assessment of uncommon melanomas can be difficult for practitioners because of their scarcity and resemblance to other dermatologic entities. Read More

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http://link.springer.com/10.1007/s40257-018-0373-6
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http://dx.doi.org/10.1007/s40257-018-0373-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244635PMC
November 2018
14 Reads

Sentinel Lymph Node Biopsy: Past and Present Implications for the Management of Cutaneous Melanoma with Nodal Metastasis.

Authors:
Abel Gonzalez

Am J Clin Dermatol 2018 Nov;19(Suppl 1):24-30

Mohs Surgery Unit, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Av San Martin 5481, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.

Although significant progress has been made in the understanding of melanoma pathophysiology and therapy, patients with metastatic melanoma still have a poor prognosis. The management of regional nodes remains a matter of debate. By replacing elective lymph node dissection, sentinel lymph node biopsy has revolutionized the treatment of malignant melanoma. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244615PMC
November 2018
6 Reads

Foreword.

Authors:
Fernando Stengel

Am J Clin Dermatol 2018 Nov;19(Suppl 1)

Buenos Aires Skin, Avenida Cordoba 1184, 10 Piso (1055), Buenos Aires, Argentina.

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http://dx.doi.org/10.1007/s40257-018-0392-3DOI Listing
November 2018
2 Reads

An Update on Drug-Induced Pigmentation.

Am J Clin Dermatol 2019 Feb;20(1):75-96

Department of Dermatology, Henry Ford Hospital, 3031 W. Grand Blvd., Suite 800, Detroit, MI, 48202, USA.

Drug-induced pigmentation accounts for up to 20% of all cases of acquired pigmentation. A thorough review of medical history and previous and ongoing medications as well as a complete skin examination can guide diagnosis. Implicated agents include alkylating/cytotoxic agents, analgesics, antiarrhythmics, anticoagulants, antiepileptics, antimalarials, antimicrobials, antiretrovirals, metals, prostaglandin analogs, and psychotropic agents, among others. Read More

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http://dx.doi.org/10.1007/s40257-018-0393-2DOI Listing
February 2019
12 Reads

Monitoring Melanoma Using Circulating Free DNA.

Am J Clin Dermatol 2019 Feb;20(1):1-12

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia.

Genetic material derived from tumours is constantly shed into the circulation of cancer patients both in the form of circulating free nucleic acids and within circulating cells or extracellular vesicles. Monitoring cancer-specific genomic alterations, particularly mutant allele frequencies, in circulating nucleic acids allows for a non-invasive liquid biopsy for detecting residual disease and response to therapy. The advent of molecular targeted treatments and immunotherapies with increasing effectiveness requires corresponding effective molecular biology methods for the detection of biomarkers such as circulating nucleic acid to monitor and ultimately personalise therapy. Read More

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http://link.springer.com/10.1007/s40257-018-0398-x
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February 2019
8 Reads

Association of Multiple Sclerosis with Psoriasis: A Systematic Review and Meta-Analysis of Observational Studies.

Am J Clin Dermatol 2018 Oct 25. Epub 2018 Oct 25.

College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: Previous studies have reported the occurrence of psoriasis together with multiple sclerosis (MS). Although similar predisposing genes and pathomechanisms have been hypothesized, the relationship between the two remains obscure.

Objective: The aim of this systematic review and meta-analysis was to investigate the association between psoriasis and MS. Read More

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http://link.springer.com/10.1007/s40257-018-0399-9
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http://dx.doi.org/10.1007/s40257-018-0399-9DOI Listing
October 2018
12 Reads

Cutaneous Adverse Effects of Diabetes Mellitus Medications and Medical Devices: A Review.

Am J Clin Dermatol 2019 Feb;20(1):97-114

Department of Pharmacy Practice and Science and Medicine, University of Arizona Colleges of Pharmacy and Medicine, Tucson, 1295 N. Martin, Tucson, AZ, 85721, USA.

Diabetes mellitus is one of the most prevalent chronic diseases in the USA. If uncontrolled, diabetes can lead to devastating complications. Diabetes medications and medical devices largely contribute to the significant financial expense that the disease inflicts on affected individuals and society. Read More

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http://link.springer.com/10.1007/s40257-018-0400-7
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http://dx.doi.org/10.1007/s40257-018-0400-7DOI Listing
February 2019
11 Reads

Shared Decision Making in Psoriasis: A Systematic Review of Quantitative and Qualitative Studies.

Am J Clin Dermatol 2019 Feb;20(1):13-29

Department of Health Sciences, Institute of Health and Society, Medical Faculty, University of Oslo, Postboks 1130, Blindern, 0318, Oslo, Norway.

Background: Patients with psoriasis face numerous treatment and self-management decisions. Shared decision making is a novel approach where patients' preferences and values are considered in cooperation with healthcare professionals before making treatment decisions.

Objective: The objective of this systematic review was to explore what is illuminated in psoriasis research regarding shared decision making, and to estimate the effects of shared decision-making interventions in this context. Read More

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http://link.springer.com/10.1007/s40257-018-0390-5
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http://dx.doi.org/10.1007/s40257-018-0390-5DOI Listing
February 2019
8 Reads

Association Between Psoriasis and Vitiligo: A Systematic Review and Meta-Analysis.

Am J Clin Dermatol 2019 Feb;20(1):31-40

Department of Dermatology, Chang Gung Memorial Hospital, Linkou, 5, Fuxing St, Guishan District, Taoyuan, 33305, Taiwan.

Background: The relationship between psoriasis and vitiligo has not been previously confirmed, and we therefore aimed to investigate this association.

Methods: We conducted a search of the MEDLINE and EMBASE electronic databases on 22 January 2018 for case-control, cross-sectional, and cohort studies examining the association between psoriasis and vitiligo. A customized Newcastle-Ottawa Scale was used to assess the risk of bias of the included studies. Read More

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http://link.springer.com/10.1007/s40257-018-0394-1
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http://dx.doi.org/10.1007/s40257-018-0394-1DOI Listing
February 2019
9 Reads

Dermatologic Conditions of the Early Post-Transplant Period in Hematopoietic Stem Cell Transplant Recipients.

Am J Clin Dermatol 2019 Feb;20(1):55-73

Washington University School of Medicine, St. Louis, MO, USA.

Hematopoietic stem cell transplants (HSCTs) are used to treat a variety of conditions, including hematologic malignancies, bone marrow failure syndromes, and immunodeficiencies. Over 60,000 HSCTs are performed annually worldwide, and the numbers continue to increase. Indeed, as new conditioning regimens develop, more and more individuals, including those of older age, will be eligible for transplants. Read More

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http://link.springer.com/10.1007/s40257-018-0391-4
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http://dx.doi.org/10.1007/s40257-018-0391-4DOI Listing
February 2019
2 Reads

Effect of Age of Onset of Psoriasis on Clinical Outcomes with Systemic Treatment in the Psoriasis Longitudinal Assessment and Registry (PSOLAR).

Am J Clin Dermatol 2018 Dec;19(6):879-886

Keck School of Medicine, University of Southern California, 1975 Zonal Avenue, Keith Administration Building, Room 510, Los Angeles, CA, 90089, USA.

Objective: Our objective was to compare therapeutic response among patients with early-onset psoriasis (EOP) and late-onset psoriasis (LOP) receiving adalimumab, etanercept, infliximab, ustekinumab, or methotrexate in the Psoriasis Longitudinal Assessment and Registry (PSOLAR).

Methods: Patients were grouped by age of onset: EOP (age ≤ 40 years) or LOP (age > 40 years). Repeated-measures analysis with logistic regression was used to calculate the adjusted odds ratio (AOR; adjusted for baseline characteristics) for achieving a Physician's Global Assessment score of cleared/minimal (PGA 0/1) or a percentage of body surface area involved with psoriasis < 3% (%BSA < 3) or %BSA < 1 for all patients; similar sensitivity analyses were performed for each treatment group. Read More

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http://dx.doi.org/10.1007/s40257-018-0388-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267545PMC
December 2018
4 Reads
2.520 Impact Factor

Mechanisms of Resistance to Immune Checkpoint Blockade.

Am J Clin Dermatol 2019 Feb;20(1):41-54

Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Yawkey 7E, Boston, MA, 02114, USA.

The recent development of effective immune checkpoint inhibition (ICI), first demonstrated in melanoma, has revolutionized cancer treatment. Monoclonal antibodies blocking the immune checkpoints cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 receptor (PD-1) have shown substantial clinical benefit in a subset of patients across tumor types and in both the metastatic and adjuvant settings. In this article, we review the interaction between the immune system and solid tumors, and describe modes of immune response failure and the physiologic role of immune checkpoints. Read More

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http://dx.doi.org/10.1007/s40257-018-0389-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358473PMC
February 2019
2 Reads
2.520 Impact Factor

Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study.

Am J Clin Dermatol 2019 Feb;20(1):147-153

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.

Background: The relationship between female pattern hair loss (FPHL) and androgenic hormones is not well established, but some evidence indicates oral finasteride may be efficacious in FPHL. Use of a topical formulation has been proposed to minimize unwanted effects.

Objectives: Our objective was to compare the efficacy and safety of topical 0. Read More

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http://dx.doi.org/10.1007/s40257-018-0387-0DOI Listing
February 2019
1 Read

Current Status of HDAC Inhibitors in Cutaneous T-cell Lymphoma.

Am J Clin Dermatol 2018 Dec;19(6):805-819

Department of Dermatology, Columbia University, 12th Floor, Herbert Irving Pavilion, 161 Fort Washington Ave, New York, NY, 10031, USA.

Cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group of lymphomas that are characterized by primary skin involvement. Mycosis fungoides (MF) and Sézary syndrome (SS), the two most common subtypes of CTCL, can be difficult to manage clinically as there are few effective treatment options available. Recently, histone deacetylase inhibitors (HDACi) have emerged as promising therapies with favorable adverse effect profiles, compared with traditional chemotherapies. Read More

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http://link.springer.com/10.1007/s40257-018-0380-7
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http://dx.doi.org/10.1007/s40257-018-0380-7DOI Listing
December 2018
12 Reads

Pediatric Onychophagia: A Survey-Based Study of Prevalence, Etiologies, and Co-Morbidities.

Am J Clin Dermatol 2018 Dec;19(6):887-891

Department of Dermatology, Weill Cornell Medicine, 1305 York Avenue, 9th Floor, New York, NY, 10021, USA.

Background: Onychophagia, defined as habitual nail biting, is a common disorder affecting 6-45% of the population and is more prevalent in children.

Objectives: Our primary objective was to determine the prevalence of nail biting in the pediatric population. Secondary objectives were to assess the presence of psychiatric co-morbidities associated with nail biting, and the effect of treatment on nail biting. Read More

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http://dx.doi.org/10.1007/s40257-018-0386-1DOI Listing
December 2018
1 Read
2.520 Impact Factor

Major Comorbidities of Atopic Dermatitis: Beyond Allergic Disorders.

Am J Clin Dermatol 2018 Dec;19(6):821-838

University of California, San Diego School of Medicine, San Diego, CA, USA.

The consequences of atopic dermatitis reach beyond the skin and past childhood. Patients with atopic dermatitis are at risk of developing allergic comorbidities, but less is known about the associations between atopic dermatitis and non-allergic conditions. Understanding these non-allergic comorbidities has the potential to improve patient outcomes and to help mitigate the cost and burdens associated with these conditions. Read More

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http://link.springer.com/10.1007/s40257-018-0383-4
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http://dx.doi.org/10.1007/s40257-018-0383-4DOI Listing
December 2018
17 Reads

Cutaneous Infections Due to Nontuberculosis Mycobacterium: Recognition and Management.

Am J Clin Dermatol 2018 Dec;19(6):867-878

Department of Dermatology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Nontuberculous mycobacteria (NTM) are a diverse group of organisms that are ubiquitous in the environment, and the incidence of cutaneous infections due to NTM has been steadily increasing. Cutaneous infections due to NTM can be difficult to diagnose, due to their wide spectrum of clinical presentations and histopathological findings that are often nonspecific. A variety of modalities including tissue culture and polymerase chain reaction (PCR) assays may be necessary to identify the organism. Read More

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http://dx.doi.org/10.1007/s40257-018-0382-5DOI Listing
December 2018
10 Reads

A Comprehensive Conceptual Model of the Experience of Chronic Itch in Adults.

Am J Clin Dermatol 2018 Oct;19(5):759-769

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Itch is common and often debilitating. Itch is best assessed by self-report, often using patient-reported outcome measures (PROMs). Current PROMs for itch are limited and may not capture its full impact on quality of life (QOL). Read More

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http://dx.doi.org/10.1007/s40257-018-0381-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161822PMC
October 2018
14 Reads

Incidence of and Risk Factors for Cutaneous Scarring after Herpes Zoster.

Am J Clin Dermatol 2018 Dec;19(6):893-897

Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgium.

Background: About 20% of children have cutaneous scars following chickenpox. In contrast, skin scars are not often reported after herpes zoster (HZ). Risk factors for post-HZ scarring remain undetermined. Read More

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http://dx.doi.org/10.1007/s40257-018-0385-2DOI Listing
December 2018
7 Reads

Enthesitis and Dactylitis in Psoriatic Disease: A Guide for Dermatologists.

Am J Clin Dermatol 2018 Dec;19(6):839-852

Hospital for Special Surgery, New York, NY, USA.

Psoriatic arthritis (PsA) is an inflammatory arthritis that is estimated to affect approximately 30% of patients with psoriasis. Enthesitis and dactylitis, two hallmarks of PsA, are associated with radiographic peripheral/axial joint damage and severe disease. Clinical symptoms of enthesitis include tenderness, soreness, and pain at entheses on palpation, whereas dactylitis is recognized by swelling of an entire digit that is different from adjacent digits. Read More

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http://link.springer.com/10.1007/s40257-018-0377-2
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http://dx.doi.org/10.1007/s40257-018-0377-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267546PMC
December 2018
18 Reads

Efficacy and Safety of Topical Cantharidin Treatment for Molluscum Contagiosum and Warts: A Systematic Review.

Am J Clin Dermatol 2018 Dec;19(6):791-803

Department of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, 676N. Saint Clair St, Suite 1600, Chicago, IL, 60611, USA.

Background And Objective: Topical cantharidin is routinely used for the treatment of molluscum contagiosum and warts. The objective of this systematic review is to assess the efficacy and safety of topical cantharidin treatment for molluscum contagiosum and warts.

Methods: We performed a systematic review of studies assessing topical cantharidin treatment of molluscum contagiosum or warts. Read More

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http://link.springer.com/10.1007/s40257-018-0375-4
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http://dx.doi.org/10.1007/s40257-018-0375-4DOI Listing
December 2018
11 Reads