Search Our Scientific Publications & Authors

Appl Clin Inform 2022 Mar 18;13(2):516-520. Epub 2022 May 18.

Clinical Informatics Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States.

In 2009, Schattauer Verlag in Stuttgart, Germany first published the () Journal. has served since its inception as an official journal of the International Medical Informatics Association. Later, the American Medical Informatics Association and the European Federation for Medical Informatics named as an official journal. Read More

Metabolism 2022 May 15:155217. Epub 2022 May 15.

Department of Medicine, Boston VA Healthcare system and Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Slosberg-Landay SL-419, Boston, MA 02215, USA. Electronic address:

The WHO just released in May 2022 a report on the state of the obesity pandemic in Europe, stating that 60% of citizens in the area of Europe are either overweight or obese, and highlighting the implications of the obesity pandemic, especially as it interacts with the COVID pandemic to create a twin pandemic, to increase morbidity and mortality. Obesity is a complex disease which has reached pandemic dimensions. The worldwide prevalence of obesity has nearly tripled since 1975, mainly due to the adoption of a progressively more sedentary lifestyle and the consumption of less healthy diets. Read More

Med (N Y) 2022 May 13;3(5):298-301. Epub 2022 May 13.

Office of Research on Women's Health, National Institutes of Health, Bethesda, MD, USA.

Systemic sources of the gender health innovation gap include inattention to the effects of sex and gender on health, underinvestment in health conditions relevant to or limited to women, workforce diversity inequities, and societal attitudes. The US federal government instituted policies and programs to address these challenges and demonstrate commitment to closing this gap with the development of the first National Strategy on Gender Equity and Equality. Read More

Addict Behav 2022 Apr 26;132:107342. Epub 2022 Apr 26.

Department of Organizational Psychology, Birkbeck, University of London, Malet Street, Bloomsbury, WC1E 7HX London, United Kingdom. Electronic address:

Introduction: The American Psychiatric Association (APA) proposed 'Internet Gaming Disorder' (IGD) as a tentative disorder (APA framework) in 2013 and in 2019 the World Health Organization (WHO) has fully recognized 'Gaming Disorder' (GD) as a mental health disorder (WHO framework). These two frameworks have not yet been jointly investigated in the context of esports. The present study aims to investigate the feasibility of the APA and WHO frameworks for disordered gaming among professional and non-professional gamers and to ascertain the suitability of existing psychometric tools for use in esports. Read More

J Appl Oral Sci 2022 16;30:e20210702. Epub 2022 May 16.

Universidade Federal de Santa Catarina - UFSC, Departamento de Patologia, Florianópolis, SC, Brasil.

Background: Dendritic cells (DCs) are specialized antigen-presenting cells that play a critical role in the immune response against human papillomavirus (HPV) infection, and represent a therapeutic target in cancer.

Objective: To identify and quantify DCs in tonsillar squamous cell carcinoma (TSCC) under the influence of HPV infection.

Methodology: CD1a and CD83 antibodies were used to identify immature dendritic cells and mature dendritic cells by immunohistochemistry in 33 primary TSCC and 10 normal tonsils (NTs), respectively. Read More

Rev Assoc Med Bras (1992) 2022 May;68(5):664-669

University of Health Sciences Turkey, Haydarpasa Numune Training and Research Hospital, Department of General Surgery - Istanbul, Turkey.

Objective: This study aimed to examine the prognostic effect of the tumor-stroma ratio, which has been shown to have prognostic value in various cancers, in patients with gallbladder cancer who have undergone curative resection.

Methods: The records of gallbladder cancer patients who underwent surgical treatment in our clinic between December 2005 and March 2021 were analyzed retrospectively. The hematoxylin and eosin-stained sections representing the tumors were evaluated under light microscopy to determine tumor-stroma ratio, and based on the results, <50% was defined as the stroma-rich and ≥50% as the stroma-poor groups. Read More

Rev Assoc Med Bras (1992) 2022 May;68(5):591-598

Massachusetts General Hospital, Colorectal Surgery Center, Department of Surgery - Boston (MA), United States.

Objective: We investigated surgical complications of elective surgery for diverticulitis in international multi-institution to identify a prediction model for potential opportunities of quality improvement.

Methods: We identified 1225 patients who underwent elective surgery for diverticulitis between January 2010 and January 2018. The data were obtained from the National Surgical Quality Improvement Program and the Turkish Diverticulitis Study Group Collaborative, retrospectively. Read More

Einstein (Sao Paulo) 2022 16;20:eAO6747. Epub 2022 May 16.

Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

Objective: To determine whether the size of thyroid nodules in ACR-TIRADS ultrasound categories 3 and 4 is correlated with the Bethesda cytopathology classification.

Methods: Thyroid nodules (566) subclassified as ACR-TIRADS 3 or 4 were divided into three size categories according to American Thyroid Association guidelines. The frequency of different Bethesda categories in each size range within ACR-TIRADS 3 and 4 classifications was analyzed. Read More

CA Cancer J Clin 2022 May 18. Epub 2022 May 18.

Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia.

Approximately one-half of individuals with cancer face personal economic burdens associated with the disease and its treatment, a problem known as financial toxicity (FT). FT more frequently affects socioeconomically vulnerable individuals and leads to subsequent adverse economic and health outcomes. Whereas multilevel systemic factors at the policy, payer, and provider levels drive FT, there are also accompanying intervenable patient-level factors that exacerbate FT in the setting of clinical care delivery. Read More

Pancreas 2022 Mar;51(3):e31-e59

Pancreas 2022 Mar;51(3):256-260

Division of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, FL.

Objectives: The aim of this article is to provide guidance to centers and organizations on the personnel (both physician and nonphysician) needed to create and sustain an optimal team, along with potential alternatives, to provide care to children with acute recurrent pancreatitis and chronic pancreatitis.

Methods: This document was developed in collaboration with the North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) Pancreas Committee and the National Pancreas Foundation (NPF) after several meetings.

Results: This document highlights both physician and nonphysician personnel needed to provide multidisciplinary care to children with pancreatitis per the recommendation of the NASPGHAN Pancreas Committee members in year 2021 and added to the currently published NPF criteria. Read More

JCO Precis Oncol 2022 May;6:e2100522

Department of Medicine, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, MA.

Purpose: The CNS is a recurrent site of progression in anaplastic lymphoma kinase (ALK)-rearranged (ALK+) lung cancer. Lorlatinib is a third-generation ALK inhibitor developed to penetrate the CNS and overcome resistance mutations. We conducted a phase II study to evaluate the intracranial activity of lorlatinib in patients with CNS-only progression on second-generation ALK inhibitors. Read More

Am J Physiol Cell Physiol 2022 May 18. Epub 2022 May 18.

Department of Pharmacology and Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Ovarian cancer is a highly aggressive disease with poor survival rates in part due to diagnosis after dissemination throughout the peritoneal cavity. It is well-known that inflammatory signals affect ovarian cancer dissemination. Inflammation is a hallmark of cellular senescence, a stable cell cycle arrest induced by a variety of stimuli including many of the therapies used to treat ovarian cancer patients. Read More

Am J Physiol Cell Physiol 2022 May 18. Epub 2022 May 18.

Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota, United States.

Chaperone-mediated autophagy (CMA) is a chaperone-dependent process of selective cytosolic protein turnover that targets specific proteins to lysosomes for degradation. Enhancing protein degradation mechanisms have been shown beneficial in multiple models of cardiac disease, including myocardial infarction (MI) and ischemia-reperfusion (I/R) injury. However, the causal role of CMA in cardiomyocyte injury and death is largely unknown. Read More

Am J Physiol Cell Physiol 2022 May 18. Epub 2022 May 18.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Syndecan-1 (SDC1, CD138) is one of the heparan sulfate proteoglycans and is essential for maintaining normal cell morphology, interacting with extracellular and intracellular protein repertoire as well as mediating signaling transduction upon environmental stimuli. The critical role of SDC1 in promoting tumorigenesis and metastasis has been increasingly recognized in various cancer types, implying a promising potential of utilizing SDC1 as a novel target for cancer therapy. This review summarizes the current knowledge on SDC1 structure and functions, including its role in tumor biology. Read More

Int J Prison Health 2022 May;ahead-of-print(ahead-of-print)

College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Purpose: Aging and mental illness both represent significant public health challenges for incarcerated people in the USA. The COVID-19 pandemic has further highlighted the vulnerabilities of incarcerated people because of the risks of infectious disease transmission in correctional facilities. Focusing on older adults with mental illness, this paper aims to examine efforts to decarcerate US correctional facilities during the COVID-19 pandemic and whether these approaches may lead to sustainable reforms beyond the pandemic. Read More

JMIR Med Educ 2022 May 17. Epub 2022 May 17.

The University of Tennessee Health Science Center, Memphis, US.

Background: The field of health information management (HIM) focuses on the protection and management of health information from a variety of sources. The American Health Information Management Association (AHIMA) Council for Excellence in Education (CEE) determines the needed skills and competencies for this field. AHIMA's HIM Curricula Competencies are divided into several domains among the associate, baccalaureate, and graduate levels. Read More

PLoS One 2022 18;17(5):e0268617. Epub 2022 May 18.

Sylvester Comprehensive Cancer Center, Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

Background: Postmenopausal breast cancer (PMBC) is the most commonly diagnosed and the second leading cause of cancer death among women in the US. Research examining the association between PMBC and education level has been inconsistent; no study in the US has examined how educational level impacts PMBC mortality in Asian American women, a largely immigrant population with above-average educational attainment.

Methods: California Vital Statistics data from 2012-2017 were analyzed to derive age-adjusted mortality rate ratios (MRRs) by education level (associates degree or above referred to as "higher education", high school, less than high school) and race [Non-Hispanic White (NHW), Asian/Pacific Islander (Asian), and its two largest subpopulations: Chinese and Filipino] from negative binomial regression models. Read More

N Engl J Med 2022 May 18. Epub 2022 May 18.

From the American Board of Internal Medicine, Philadelphia (R.J.B., Y.D.E.); and Brown University, Providence, RI (Y.D.E.).

PLoS One 2022 18;17(5):e0266785. Epub 2022 May 18.

U.S. Geological Survey, Kansas Cooperative Fish and Wildlife Research Unit, Kansas State University, Manhattan, Kansas, United States of America.

Globally, migration phenologies of numerous avian species have shifted over the past half-century. Despite North American waterfowl being well researched, published data on shifts in waterfowl migration phenologies remain scarce. Understanding shifts in waterfowl migration phenologies along with potential drivers is critical for guiding future conservation efforts. Read More

Proc Natl Acad Sci U S A 2022 May 18;119(21):e2203928119. Epub 2022 May 18.

Department of Genetics, Harvard Medical School, Boston, MA 02115.

SignificanceThe genetic basis of isolated microtia, a congenital abnormality of the external ear, is poorly understood. Indigenous American (Amerindigenous) populations have the highest reported incidence of microtia. Here, we use whole genome sequencing to study microtia in Latin American families and identify a common microtia risk allele that is enriched among individuals with Amerindigenous ancestry. Read More

Mycologia 2022 May 18:1-9. Epub 2022 May 18.

Department of Native American Studies, University of California, Davis, California 95616.

We studied the effect of rutin on mycelial growth and fruiting of , and on sunflower husks and on agar nutrient media. On sunflower husks, rutin (300 mg/30 g husk) inhibits the mycelial growth of , but the formation of fruiting bodies of the fungus occurs 3 weeks earlier than on the substrate, where rutin was not used. In half of the cases with rutin, we observed two waves of fungus fruiting. Read More

Int Rev Psychiatry 2022 Feb 28;34(1):34-50. Epub 2022 Apr 28.

School of Public Health, University of Alberta, Edmonton, Canada.

As climate change progresses, it is crucial that researchers and policymakers understand the ways in which climate-mental health risks arise through interactions between climate hazards, human exposure and social vulnerabilities across time and location. This scoping review systematically examined the nature, range and extent of published research in North America that investigates climate-mental health interactions. Five electronic databases were searched and two independent reviewers applied pre-determined criteria to assess the eligibility of articles identified in the search. Read More

J Trauma Acute Care Surg 2022 May 18. Epub 2022 May 18.

Professor Emeritus, University of California San Francisco, San Francisco, CA; Adjunct Professor, Uniformed Services University for the Health Sciences, Bethesda, MD; Medical Director, Military Health System Strategic Partnership, American College of Surgeons, Chicago, IL.

Background: The Blue Book, published in conjunction with the Military Health System Strategic Partnership with the American College of Surgeons, serves as a reference manual for institutions wishing to establish a military-civilian partnership. In order to evaluate the applicability of the criteria contained in the Blue Book, we created a survey to be distributed to MCP military surgeons and their civilian host champions.

Methods: E-mail surveys were sent to MCP military surgeons and civilian host champions. Read More

Plast Reconstr Surg 2022 May 19. Epub 2022 May 19.

From the Division of Plastic and Reconstructive Surgery, the Department of Anesthesiology and Critical Care Medicine, and the Department of Surgery, University of New Mexico.

Background: Readmission is an important metric for surgical quality of care. This study aimed to develop a validated risk model that reliably predicts readmission after panniculectomy using the American College of Surgeons National Surgical Quality Improvement Program database.

Methods: The American College of Surgeons National Surgical Quality Improvement Program database was queried to identify all patients who had undergone panniculectomy from 2005 to 2018. Read More

Acad Med 2022 May 17. Epub 2022 May 17.

D. Boatright is assistant professor, Department of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut.

Purpose: To examine demographic characteristics of matriculants to U.S. MD-PhD programs by sex and race/ethnicity from academic years (AYs) 2009-2018 and explore the relationships between trends in the percentage of female and underrepresented minority (URM) matriculants to programs with and without Medical Scientist Training Program (MSTP) funding. Read More

JAMA Cardiol 2022 May 18. Epub 2022 May 18.

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

Importance: Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death in young people. Although rare genetic variants are well-established contributors to HCM risk, common genetic variants have recently been implicated in disease pathogenesis.

Objective: To assess the contributions of rare and common genetic variation to risk of HCM in the general population. Read More

JAMA Surg 2022 May 18. Epub 2022 May 18.

Surgical Outcomes Quality Improvement Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Importance: Differences in time to diagnostic and therapeutic measures can contribute to disparities in outcomes. However, whether there is an association of timeliness by sex for trauma patients is unknown.

Objective: To investigate whether sex-based differences in time to definitive interventions exist for trauma patients in the US and whether these differences are associated with outcomes. Read More

Am J Reprod Immunol 2022 May;87 Suppl 1:1-107

Langenbecks Arch Surg 2022 May 18. Epub 2022 May 18.

Department of Surgery, Maine Medical Center, Portland, ME, USA.

Purpose: The International Abstract(s) of Surgery (IAS) was a monthly supplement to Surgery, Gynecology & Obstetrics (SG&O, later Journal of the American College of Surgeons) from 1913-1994, approximately equal in size to the journal itself. It followed the example of the Zentralblatt für Chirurgie (ZblCh), which had been compiling abstracts of the current world surgical literature since 1874 (but in the German language). This article seeks to review the relationships of these surgical abstract journals in historical context. Read More