1,632 results match your criteria American Journal On Addictions[Journal]


Evaluation of a Novel Protocol for Assessment and Treatment of Alcohol Withdrawal Syndrome in Psychiatric Inpatients.

Am J Addict 2020 Jun 3. Epub 2020 Jun 3.

Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.

Background And Objectives: Despite the high incidence of alcohol withdrawal syndrome (AWS) in psychiatric inpatients, standardized methods for assessing and treating AWS have been studied only once before in this population. We evaluated a novel AWS assessment and treatment protocol designed for psychiatric inpatients.

Methods: This retrospective cohort study evaluated outcomes before and after implementation of the protocol. Read More

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http://dx.doi.org/10.1111/ajad.13058DOI Listing

Brief Report: Relationship Between Cotinine Levels and Peripheral Endogenous Concentrations of Oxytocin, β-Endorphin, and Orexin in Individuals With Both Alcohol and Nicotine Use Disorders.

Am J Addict 2020 Jun 2. Epub 2020 Jun 2.

Department of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island.

Background And Objectives: In this secondary analysis of a pilot clinical trial with individuals with alcohol and nicotine use disorders, we investigate the relationship between serum concentrations of oxytocin, β-endorphin, melatonin, α-melanocyte-stimulating hormone, substance P, and orexin, with objective biomarkers (salivary cotinine and serum γ-glutamyl transferase [GGT]) as well as with self-reported smoking and alcohol drinking.

Methods: Biomarkers for a total of N = 19 participants were analyzed using multiplexed, competitive format immune-assay (peptides) and enzyme competitive immunoassay (saliva). A regression analysis using Pearson's correlation coefficient was utilized to determine correlations. Read More

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http://dx.doi.org/10.1111/ajad.13064DOI Listing

Zonisamide as an Adjunctive Treatment to Cognitive Processing Therapy for Veterans With Posttraumatic Stress Disorder and Comorbid Alcohol Use Disorder: A Pilot Study.

Am J Addict 2020 May 27. Epub 2020 May 27.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

Background And Objectives: There are high rates of comorbid alcohol use disorder (AUD) among those who have posttraumatic stress disorder (PTSD). Ideally, treatment for comorbidity should address both disorders simultaneously. Zonisamide, an anticonvulsant, may be effective in decreasing alcohol use and may attenuate symptoms of PTSD. Read More

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http://dx.doi.org/10.1111/ajad.13061DOI Listing

Substance Use and Mental Health in Emerging Adult Vs Older Adult Men and Women With Opioid Use Disorder.

Am J Addict 2020 May 21. Epub 2020 May 21.

Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts.

Background And Objectives: We examined age differences across genders in clinical characteristics in emerging adult (≤25 years) vs older adult patients (26+ years) with opioid use disorder (OUD).

Methods: Participants (N = 570; 30% female) entering a comparative effectiveness medication trial of buprenorphine vs extended-release naltrexone.

Results: Differences in clinical characteristics in emerging adult vs older participants were similar across genders. Read More

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http://dx.doi.org/10.1111/ajad.13059DOI Listing

Alexithymia, Emotion-Regulation Strategies, and Traumatic Experiences in Prenatally Cocaine-Exposed Young Adults.

Am J Addict 2020 May 20. Epub 2020 May 20.

Child Study Center, Yale University School of Medicine, New Haven, Connecticut.

Background And Objectives: Exposure to early-life trauma may lead to maladaptive characteristics such as alexithymia, and thus to poorer emotional regulation. This relationship may also be influenced by exposure to substances prenatally. We hypothesized that increased alexithymia would be seen in those with prenatal cocaine exposure (PCE). Read More

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http://dx.doi.org/10.1111/ajad.13056DOI Listing

Disentangling the Social Context of Nonmedical Use of Prescription Stimulants in College Students.

Am J Addict 2020 May 20. Epub 2020 May 20.

School of Nursing and Institute for Research on Women and Gender, Center for the Study of Drugs, Alcohol, Smoking and Health, University of Michigan, Ann Arbor, Michigan.

Background And Objectives: The aim of this study was to investigate the social context of nonmedical use of prescription stimulants (NMUPS) among college students who endorsed NMUPS with co-occurring substance use disorders (SUD) compared with those without co-occurring SUDs.

Methods: Presented here are new analyses based on data previously collected from college students aged 18 to 28 years derived from the Boston metropolitan area who endorsed NMUPS (N = 100) at least once in their lifetime. Differences between those with lifetime history of SUD (N = 46) and without a history of SUD (N = 54) on the Massachusetts General Hospital ADHD Medication Misuse and Diversion Assessment were analyzed using the Student t test, the Pearson χ test, and the Wilcoxon rank-sum test. Read More

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http://dx.doi.org/10.1111/ajad.13053DOI Listing

Methadone-Assisted Opiate Withdrawal and Subsequent Heroin Abstinence: The Importance of Psychological Preparedness.

Am J Addict 2020 May 19. Epub 2020 May 19.

Department of Psychology, Edge Hill University, Ormskirk, UK.

Background And Objectives: Treatment guidelines emphasize patients' readiness for transitioning from opiate substitution treatment (OST) to opiate withdrawal and abstinence. Psychological preparedness indicators for this transition were examined.

Methods: Patients (all male) were recruited from three treatment settings: prison, an inpatient detoxification unit, and an outpatient clinic. Read More

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http://dx.doi.org/10.1111/ajad.13062DOI Listing

Systematic Review: Treatment for Addictive Disorder in Transplant Patients.

Am J Addict 2020 May 14. Epub 2020 May 14.

Yale University School of Medicine, New Haven, Connecticut.

Background And Objectives: The number of patients with substance use disorders in need for organ transplantation is expected to increase. Patients with addictive disorders are considered a higher risk of negative outcomes after organ transplantation due to the impact of substance use upon medical status and adherence with treatment. The goal of this systematic review was to assess the current literature on treatment for addiction transplant candidates and recipients. Read More

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http://dx.doi.org/10.1111/ajad.13054DOI Listing

Ten Years of Experience With Buprenorphine in a Private Psychiatric Outpatient Practice.

Authors:
Robert Feder

Am J Addict 2020 May 14. Epub 2020 May 14.

Private Practice, Manchester, New Hampshire.

Background And Objectives: There have been few reports of buprenorphine treatment of opioid use disorder in private psychiatric practice. This report describes such a patient population and the outcomes obtained.

Methods: Chart reviews were performed on 285 patients seen over a 10-year period in the author's solo private psychiatric practice. Read More

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http://dx.doi.org/10.1111/ajad.13060DOI Listing

Mobile, Community-Based Buprenorphine Treatment for Veterans Experiencing Homelessness With Opioid Use Disorder: A Pilot, Feasibility Study.

Am J Addict 2020 May 4. Epub 2020 May 4.

Yale University School of Medicine, New Haven, Connecticut.

Background And Objectives: Adults experiencing homelessness with opioid use disorder (OUD) utilize buprenorphine (BUP), a first-line medication for OUD, at very low rates. Innovative and tailored approaches are needed to reduce barriers to treatment and increase utilization of BUP in this population. This study describes a pilot Mobile Community-based Access Team (M-CAT) that used mobile technology and FaceTime in addition to existing community-based case management programs to provide BUP treatment for veterans with OUD experiencing homelessness who had difficulties engaging in the regular BUP clinic. Read More

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http://dx.doi.org/10.1111/ajad.13055DOI Listing

Associations Between Self-Reported and Biological Measures of Nicotine Consumption Among Young Adult Nondaily Cigarette Smokers.

Am J Addict 2020 May 2. Epub 2020 May 2.

Department of Psychiatry, University of California, San Diego, San Diego, California.

Background And Objectives: Intermittent, dual use of cigarettes and e-cigarettes is a common pattern among youth and young adults. However, little is known about the validity of self-report measures of nicotine consumption in these populations. The goal of the present study was to examine associations between self-reported frequency of cigarette and e-cigarette use and nicotine levels in hair samples at two assessments 1 year apart. Read More

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http://dx.doi.org/10.1111/ajad.13052DOI Listing

Excessive Spending in a "Free-to-Play" Smartphone Game.

Am J Addict 2020 Apr 30. Epub 2020 Apr 30.

Stanford University School of Medicine, Palo Alto, California.

Background And Objectives: Although gaming disorder is increasingly recognized, there has been limited consideration of the impact of free-to-play games with in-game purchases, also called microtransactions.

Methods: Case report (n = 1).

Results: A patient with posttraumatic stress disorder, major depressive disorder in remission, polysubstance use disorders in remission, and opioid use disorder on buprenorphine/naloxone developed gaming disorder (based on International Classification of Diseases, 11th revision) and spent up to 40% of his monthly income on microtransactions within a smartphone game. Read More

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http://dx.doi.org/10.1111/ajad.13049DOI Listing

A Case Report: Rapid Micro-Induction of Buprenorphine/Naloxone to Administer Buprenorphine Extended-Release in an Adolescent With Severe Opioid Use Disorder.

Am J Addict 2020 Apr 29. Epub 2020 Apr 29.

British Columbia Centre on Substance Use, British Columbia Centre for Excellence, St. Paul's Hospital, Vancouver, British Columbia, Canada.

Background And Objectives: Buprenorphine extended-release (BUP-XR) is a monthly injectable form of opioid agonist therapy. Before its administration, a minimum 7-day induction period with a transmucosal buprenorphine-containing product is recommended.

Methods: Case report (n = 1). Read More

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http://dx.doi.org/10.1111/ajad.13050DOI Listing

A Literature Review Examining Primary Outcomes of Medication Treatment Studies for Opioid Use Disorder: What Outcome Should Be Used to Measure Opioid Treatment Success?

Am J Addict 2020 Apr 29. Epub 2020 Apr 29.

Department of Internal Medicine, Section of Infectious Diseases, AIDS Program, New Haven, Connecticut.

Background And Objectives: Medications for opioid use disorder (MOUD) reduce opioid use and overdose; however, MOUD clinical trials have used varying primary outcomes to document treatment success. We conducted a literature review to assess and critically examine the methodologies used in MOUD treatment studies.

Methods: Published studies in English that examined MOUD (buprenorphine, methadone, or extended-release naltrexone) were included (N = 20). Read More

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http://dx.doi.org/10.1111/ajad.13051DOI Listing

2019 Annual Meeting Recap.

Authors:

Am J Addict 2020 May;29(3):179-185

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http://dx.doi.org/10.1111/ajad.13030DOI Listing

Editorial: The Year in Review Amidst the COVID-19 Crisis.

Am J Addict 2020 05;29(3):172-173

Deputy Editor, The American Journal on Addictions.

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http://dx.doi.org/10.1111/ajad.13046DOI Listing

Symposia, Case Conference, and Medical Update.

Authors:

Am J Addict 2020 May;29(3):186-193

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http://dx.doi.org/10.1111/ajad.13029DOI Listing

2019 Reviewers - The AJA.

Authors:

Am J Addict 2020 May;29(3):176-178

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http://dx.doi.org/10.1111/ajad.13047DOI Listing

Poster Presentation Abstracts (CME and Non-CME).

Authors:

Am J Addict 2020 May;29(3):194-233

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http://dx.doi.org/10.1111/ajad.13032DOI Listing

Nitrous Oxide Inhalant Use Disorder Preceding Symptoms Concerning for Primary Psychotic Illness.

Am J Addict 2020 Apr 25. Epub 2020 Apr 25.

Department of Psychiatry, New York University, New York, New York.

Background And Objective: Nitrous oxide has long been used recreationally for its ability to induce euphoria and other deliriant effects. In modern times, it remains a popular, legal, and widely available option for those seeking altered states. Though substance-induced psychotic symptoms have been mentioned in the literature, the potential long-term negative neuropsychiatric effects related to its use have not been well established. Read More

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http://dx.doi.org/10.1111/ajad.13048DOI Listing

Editorial: Challenges to Opioid Use Disorders During COVID-19.

Am J Addict 2020 05 13;29(3):174-175. Epub 2020 Apr 13.

Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, China.

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http://dx.doi.org/10.1111/ajad.13031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262307PMC

Association of Mood and Anxiety Disorders and Opioid Prescription Patterns Among Postpartum Women.

Am J Addict 2020 Apr 6. Epub 2020 Apr 6.

Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa.

Background And Objectives: Postpartum women represent a large population with opioid exposure who also have an increased risk of experiencing mood and anxiety disorders. However, the effect that mood and anxiety disorders have on opioid use postpartum has received little attention in the literature. Therefore, the objective of this study was to examine the association of mood and anxiety disorders with filling opioid prescriptions within the first 3 months postpartum. Read More

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http://dx.doi.org/10.1111/ajad.13028DOI Listing

Transition of Patients with Opioid Use Disorder from Buprenorphine to Extended-Release Naltrexone: A Randomized Clinical Trial Assessing Two Transition Regimens.

Am J Addict 2020 Apr 4. Epub 2020 Apr 4.

Department of Psychiatry, Columbia University Irving Medical Center, New York, New York.

Background And Objective: When patients seek to discontinue buprenorphine (BUP) treatment, monthly injectable extended-release naltrexone (XR-NTX) may help them avoid relapse. The efficacy of low ascending doses of oral NTX vs placebo for patients transitioning from BUP to XR-NTX is evaluated in this study.

Methods: In a phase 3, hybrid residential/outpatient study, clinically stable participants with opioid use disorder (N = 101), receiving BUP for more than or equal to 3 months and seeking antagonist treatment, were randomized (1:1) to 7 residential days of descending doses of BUP and low ascending doses of oral NTX (NTX/BUP, n = 50) or placebo (PBO-N/BUP, n = 51). Read More

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http://dx.doi.org/10.1111/ajad.13024DOI Listing

Brief Report: Opioid-Involved Overdose Mortality in United States Veterans.

Am J Addict 2020 Mar 29. Epub 2020 Mar 29.

Office of Mental Health and Suicide Prevention, Veterans Health Administration (VA), Washington, District of Columbia.

Background And Objectives: The purpose of this study is to assess trends in opioid-involved overdose mortality among US Veterans.

Methods: Age-adjusted drug overdose mortality rates, overall and by opioid subtype, were assessed from National Death Index data for US Veterans; statistical significance of trends was assessed for 2010 to 2015 and 2015 to 2016.

Results: Veteran age-adjusted overdose mortality rates increased 23. Read More

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http://dx.doi.org/10.1111/ajad.13027DOI Listing

Alcohol Use Disorder Among Adults Recovered From Substance Use Disorders.

Am J Addict 2020 Mar 26. Epub 2020 Mar 26.

Department of Psychiatry, School of Medicine, Yale University, New Haven, Connecticut.

Background And Objectives: Alcohol use is often overlooked and underestimated among patients recovered from substance dependence. The prevalence and correlates of alcohol use disorder (AUD) among adults recovered from substance use disorders (SUDs) are estimated in this study.

Methods: A nationally representative cross-sectional analysis of the National Epidemiological Survey on Alcohol and Related Conditions Wave-III was used in this study. Read More

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http://dx.doi.org/10.1111/ajad.13026DOI Listing

Association of Cannabis Use With Intimate Partner Violence Among Couples With Substance Misuse.

Am J Addict 2020 Mar 26. Epub 2020 Mar 26.

Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina.

Background And Objectives: There is a well-established causal link between substance use and intimate partner violence (IPV) perpetration and victimization. However, little is known about the complex emerging relationship between cannabis use and IPV. Because cannabis is the most commonly used drug in the United States and is associated with numerous IPV risk factors such as alcohol use, it is important to examine this relationship in greater detail. Read More

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http://dx.doi.org/10.1111/ajad.13025DOI Listing

Incidence of Postoperative Opioid Overdose and New Diagnosis of Opioid Use Disorder Among US Veterans.

Am J Addict 2020 Mar 22. Epub 2020 Mar 22.

VA Maryland Health Care System, Baltimore, Maryland.

Background And Objectives: Perioperative exposure to opioids is associated with adverse outcomes. We aim to determine the associations between surgery and subsequent opioid overdose, an acute event, and a new diagnosis of opioid use disorder (OUD), a chronic relapsing disease, in parallel.

Methods: This retrospective cohort study of US veterans used surgery as exposure and the two outcomes were (1) occurrence of overdose and (2) new diagnosis of OUD in the first postoperative year. Read More

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http://dx.doi.org/10.1111/ajad.13022DOI Listing

Physicians' and Attorneys' Beliefs and Attitudes Related to the Brain Disease Model of Addiction.

Am J Addict 2020 Mar 18. Epub 2020 Mar 18.

Department of Psychology, Princeton University, Princeton, New Jersey.

Background And Objectives: Addiction is increasingly considered a chronic, relapsing brain disease; however, many scholars still disagree with the brain disease model of addiction. We set out to provide evidence of attorneys' and physicians' beliefs regarding the model. First, we asked the following question: do attorneys and physicians affirm the full brain disease model, or its modified form, or do they believe that addiction is driven by deficits in self-control or moral weakness? Second, we evaluated the extent to which such beliefs correspond to attitudes toward individuals with substance use disorders (SUDs). Read More

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http://dx.doi.org/10.1111/ajad.13023DOI Listing

Initial Information on a Novel Nicotine Product.

Am J Addict 2020 Mar 16. Epub 2020 Mar 16.

James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky.

Background And Objectives: This is the first study to assess the appeal and interest among adults in a new consumer tobacco product, ZYN. We also describe ZYN users, patterns of use, and reasons for use.

Methods: Two data sets, consisting of a ZYN-naive consumer panel (n = 5179) and ZYN users (n = 1266), were provided by Swedish Match North America. Read More

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http://dx.doi.org/10.1111/ajad.13020DOI Listing

Case Series: Rapid Induction Onto Long Acting Buprenorphine Injection for High Potency Synthetic Opioid Users.

Am J Addict 2020 Mar 13. Epub 2020 Mar 13.

Division on Substance Use Disorders, New York State Psychiatric Institute, New York, New York.

Background And Objectives: Highly potent synthetic opioids (HPSO) are increasingly responsible for opioid overdose deaths in the United States.

Methods: In an open-label, uncontrolled trial to test the feasibility of extended-release buprenorphine (BXR) injection treatment of heroin-using individuals with opioid use disorder testing positive for HPSO, participants were enrolled and began an induction with sublingual BXR (n = 5). During the induction, ancillary medications (clonidine, clonazepam, zolpidem, and prochlorperazine) were provided for breakthrough opioid withdrawal symptoms. Read More

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http://dx.doi.org/10.1111/ajad.13018DOI Listing

Buprenorphine Treatment for Opioid Use Disorder in Community-Based Settings: Outcome Related to Intensity of Services and Urine Drug Test Results.

Am J Addict 2020 Mar 11. Epub 2020 Mar 11.

Dominion Diagnostics, North Kingstown, Rhode Island.

Background And Objectives: Variables contributing to the outcome of buprenorphine treatment for opiate use disorder have been studied, including patient characteristics and the treatment approach applied. It is also valuable to study the types of clinical facilities that can affect outcome.

Methods: We evaluated patients (N = 20 993) in 573 facilities where buprenorphine was prescribed. Read More

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http://dx.doi.org/10.1111/ajad.13001DOI Listing

The Effects of Cannabis Use: A Test Among Dual Electronic and Combustible Cigarette Users.

Am J Addict 2020 Mar 11. Epub 2020 Mar 11.

Department of Psychology, University of Houston, Houston, Texas.

Background And Objectives: Despite greater rates of cannabis use among those that smoke combustible cigarettes, it is currently unknown whether cannabis use is related to e-cigarette dependence or maladaptive beliefs about combustible cigarettes. Therefore, the current study sought to identify whether adult dual users of combustible and e-cigarettes (ie, dual users) who also used cannabis differed from dual users who did not use cannabis on e-cigarette dependence severity, perceived barriers to quitting, and perception of risks and of benefits of e-cigarettes.

Methods: Participants were 414 current dual users (48. Read More

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http://dx.doi.org/10.1111/ajad.13021DOI Listing

Heart Rate Variability Reactivity Moderates the Indirect Link Between Child Maltreatment and Young Adult Alcohol Use Problems Via Depressive Symptoms.

Am J Addict 2020 03 12;29(2):141-150. Epub 2020 Feb 12.

Department of Psychiatry, University of Rochester Medical Center, Rochester, New York.

Background And Objectives: Young adults with childhood maltreatment (CM) histories are particularly vulnerable to depressive symptoms and alcohol use problems. Research suggests that maltreated youth may misuse alcohol in part to alleviate depressive symptoms. However, many youths with depressive symptoms exercise self-control and abstain from heavy alcohol use. Read More

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http://dx.doi.org/10.1111/ajad.13004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236811PMC

Pain Severity and Alcohol Use Among Daily Tobacco Cigarette Smokers.

Am J Addict 2020 03 3;29(2):134-140. Epub 2020 Feb 3.

Department of Psychology, Syracuse University, Syracuse, New York.

Background And Objectives: Pain is associated with hazardous alcohol use. Drinkers have reported using alcohol for pain-coping, and negative affect may be a key mechanism in pain-induced motivation to drink. However, no previous study has examined pain severity in relation to alcohol consumption, dependence, and alcohol-related consequences. Read More

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http://dx.doi.org/10.1111/ajad.13003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035147PMC

GRIN2B Gene Polymorphism in Chronic Ketamine Users.

Am J Addict 2020 03 19;29(2):105-110. Epub 2020 Jan 19.

Guangzhou Huiai Hospital, The Affiliated Brain Hospital of Guangzhou Medical University, 36 Mingxin Road, Liwan District, Guangzhou, Guangdong, 510370, China.

Background And Objectives: We examined the allelic variants of N-methyl- d-aspartate receptor 2B (GRIN2B) and analyzed the associations between GRIN2B gene polymorphism with ketamine use conditions and psychopathological symptoms in chronic ketamine users.

Methods: A total of 231 subjects were recruited. Four single nucleotide polymorphisms of GRIN2B, rs1805502, rs7301328, rs890, and rs1806201 were examined in 151 male chronic ketamine users and 80 controls. Read More

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http://dx.doi.org/10.1111/ajad.12984DOI Listing

Predictors of Medication Utilization for Opioid Use Disorder Among Medicaid-Insured HIV Patients in New York.

Am J Addict 2020 03 17;29(2):151-154. Epub 2020 Jan 17.

Department of Health Services Research, Center on Addiction, New York, New York.

Background And Objectives: This paper investigates the prevalence and predictors for opioid use disorder (OUD) pharmacotherapy utilization for Medicaid-insured patients with human immunodeficiency virus (HIV) in New York.

Methods: We identified patients with HIV and OUD in 2014 in the New York State Medicaid claims data (n = 5621). The claims were used to identify individual client medication for addiction treatment (MAT) utilization, demographic information, and other medical and psychiatric health conditions. Read More

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http://dx.doi.org/10.1111/ajad.12998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035191PMC

Does Cannabis Dependence Add on to the Neurocognitive Impairment Among Patients With Opioid Dependence? A Cross-Sectional Comparative Study.

Am J Addict 2020 03 17;29(2):120-128. Epub 2020 Jan 17.

Department of Psychiatry, Drug De-addiction and Treatment Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background And Objectives: Chronic opioid exposure has been linked with neurocognitive impairments. Evidence of residual impairment with cannabis use is less consistent. We investigated whether patients with opioid and cannabis dependence perform poorly compared with those with opioid dependence alone. Read More

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http://dx.doi.org/10.1111/ajad.12986DOI Listing

Sex Differences in Korsakoff's Syndrome for Inhibition but Not for Episodic Memory or Flexibility.

Am J Addict 2020 03 15;29(2):129-133. Epub 2020 Jan 15.

CNRS, CHU Lille, UMR 9193 SCALab-Sciences Cognitives et Sciences Affectives, University of Lille, F-59000, Lille, France.

Background And Objectives: While sex differences in cognitive abilities have been extensively studied in healthy populations, little is known about these differences in patients with Korsakoff syndrome (KS).

Methods: We investigated sex differences in verbal episodic memory, inhibition, and flexibility in 25 patients with KS and 25 control participants.

Results: The analysis demonstrated no significant differences between women with KS and men with KS on episodic memory and flexibility, but higher inhibition was observed in women with KS compared with men with KS. Read More

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http://dx.doi.org/10.1111/ajad.12999DOI Listing

Impact of Medications for Opioid Use Disorder on Discharge Against Medical Advice Among People Who Inject Drugs Hospitalized for Infective Endocarditis.

Am J Addict 2020 03 12;29(2):155-159. Epub 2020 Jan 12.

Harvard Medical School, Boston, Massachusetts.

Background And Objectives: The impact of medications for opioid use disorder (MOUD) on against medical advice (AMA) discharges among people who inject drugs (PWID) hospitalized for endocarditis is unknown.

Methods: A retrospective review of all PWID hospitalized for endocarditis at our institution between 2016 and 2018 (n = 84).

Results: PWID engaged with MOUD at admission, compared with those who were not, were less likely to be discharged AMA but this did not reach statistical significance in adjusted analysis (odds ratio [OR], 0. Read More

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http://dx.doi.org/10.1111/ajad.13000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035155PMC

Methamphetamine Use and Sexual Risk Behaviors among Men Who Have Sex With Men in a Mexico-US Border City.

Am J Addict 2020 03 7;29(2):111-119. Epub 2020 Jan 7.

Alliance of Border Collaboratives, El Paso, Texas.

Background And Objectives: Methamphetamine (meth) use and its related risk behaviors for HIV among men who have sex with men (MSM) are a public health concern across the Mexico-US border. This study aims to contribute to the limited literature of meth use and sexual risk behaviors among Latino MSM on the Mexico-US border.

Methods: Data were drawn from the Meth Pilot Study (2014-2015) among men who use meth (n = 100). Read More

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http://dx.doi.org/10.1111/ajad.12985DOI Listing

Cumulative Risk of Substance Use in Community College Students.

Am J Addict 2020 03 3;29(2):97-104. Epub 2020 Jan 3.

Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.

Background And Objectives: Substance use in community college students has been explored in only a handful of studies. Differences in population characteristics and substance use between 2- and 4-year students suggest that different factors may promote and thwart this behavior. Cumulative risk is a parsimonious methodology that provides better model stability and more statistical power, yet it has only been recently used in substance use research. Read More

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http://dx.doi.org/10.1111/ajad.12983DOI Listing

Physician and Pharmacist: Attitudes, Facilitators, and Barriers to Prescribing Naloxone for Home Rescue.

Am J Addict 2020 01 5;29(1):65-72. Epub 2019 Dec 5.

Department of Psychiatry, University of California San Diego Health, San Diego, California.

Background And Objectives: We implemented a naloxone education and distribution program in our academic health system. Despite the program, naloxone prescribing was not fully realized. This study aimed to identify the barriers to prescribing. Read More

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http://dx.doi.org/10.1111/ajad.12982DOI Listing
January 2020

Brief Report: Problem Gambling in International and Domestic University Students.

Am J Addict 2020 01 3;29(1):77-81. Epub 2019 Dec 3.

School of Psychology, Deakin University, Geelong, Victoria, Australia.

Background And Objectives: International students comprise an ethnic minority subpopulation who may be at increased risk for the development of gambling problems. This study aimed to explore the psychosocial factors associated with gambling problems in international and domestic university students in Australia.

Methods: One hundred seventy-three (n = 173) university students (127 domestic, 45 international) completed measures of gambling participation, problem gambling, psychosocial factors (depression, anxiety, perceived social support, loneliness, gambling-related cognitive distortions) and English language difficulties. Read More

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http://dx.doi.org/10.1111/ajad.12981DOI Listing
January 2020

Distress-Related Internalizing Symptoms Interact With Externalizing Symptoms to Predict Alcohol Problems in an Inpatient Adolescent Sample.

Am J Addict 2020 01 29;29(1):57-64. Epub 2019 Nov 29.

Department of Psychology, University at Buffalo, The State University of New York, Buffalo, New York.

Background And Objectives: Previous research has yielded equivocal findings regarding whether internalizing symptoms are risk factors for adolescent hazardous alcohol use (AU), specifically in the presence of externalizing symptoms. This may be due to the type of internalizing symptoms examined (ie, distress vs fear), and the use of primarily normative rather than clinical samples. Thus, we tested internalizing and externalizing symptom interactions as they relate to adolescent hazardous AU in a high-risk, clinical sample of adolescents. Read More

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http://dx.doi.org/10.1111/ajad.12980DOI Listing
January 2020
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Naloxone-Induced Withdrawal in Individuals With and Without Fentanyl-Positive Urine Samples.

Am J Addict 2020 01 29;29(1):51-56. Epub 2019 Nov 29.

Division on Substance Use Disorders, New York State Psychiatric Institute and Columbia University Vagelos College of Physicians and Surgeons, New York, New York.

Background And Objective: This retrospective analysis of data from heroin users screening for clinical research, sought to determine if more naloxone is needed to precipitate opioid withdrawal among those who regularly use heroin with fentanyl, as opposed to those who use heroin without fentanyl.

Methods: Over the course of three to five screening visits, participants completed assessments of drug use, along with urine toxicology tests at each visit. To test for opioid dependence, 29 participants completed a modified Wang test (score: 0-150) during which an intramuscular dose of naloxone (0. Read More

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http://dx.doi.org/10.1111/ajad.12979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927546PMC
January 2020

Association of Craving and Depressive Symptoms in Ketamine-Dependent Patients Undergoing Withdrawal Treatment.

Am J Addict 2020 01 6;29(1):43-50. Epub 2019 Nov 6.

Department of Psychiatry, Yale University School of Medicine, New Heaven, Connecticut.

Background And Objectives: Ketamine has emerged as one of the major illicit substances worldwide. Craving, a primary symptom for addiction, is a key challenge for ketamine abusers attempting abstinence. A link between craving and negative affect has been suggested previously for other substances. Read More

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http://dx.doi.org/10.1111/ajad.12978DOI Listing
January 2020

Case Series: Limited Opioid Withdrawal With Use of Transdermal Buprenorphine to Bridge to Sublingual Buprenorphine in Hospitalized Patients.

Am J Addict 2020 01 18;29(1):73-76. Epub 2019 Oct 18.

Mental Health and Addictions Service, St. Michael's Hospital, Toronto, Ontario, Canada.

Background: Prerequisite opioid withdrawal symptoms prior to buprenorphine induction are unacceptable to many patients. We assessed whether transdermal buprenorphine minimized withdrawal while bridging to sublingual therapy among hospital inpatients.

Methods: Retrospective chart review of (n = 23) inpatients with opioid use disorder or opioid dependence due to chronic pain. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ajad.12964
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http://dx.doi.org/10.1111/ajad.12964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134509PMC
January 2020
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Comparing Changes in Controlled Substance Prescribing Trends by Provider Type.

Am J Addict 2020 01 10;29(1):35-42. Epub 2019 Oct 10.

Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, Kentucky.

Background And Objectives: Forty-nine out of 50 states have implemented Prescription Drug Monitoring Programs (PDMPs) to monitor controlled substance (CS) prescribing. PDMPs change health care provider behavior, but few studies have examined changes in CS prescription by health care provider type.

Methods: Aggregated yearly data, including number of CS prescriptions, doses, and doses per prescription by health care provider type (physician, advanced practice registered nurse [APRN], and dentist) for each year from 2011 to 2017 was provided by the state PDMP, Kentucky All Schedule Prescription Electronic Reporting System (KASPER). Read More

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http://dx.doi.org/10.1111/ajad.12962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941737PMC
January 2020
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Cannabis and Cannabinoids in Mood and Anxiety Disorders: Impact on Illness Onset and Course, and Assessment of Therapeutic Potential.

Am J Addict 2020 01 2;29(1):9-26. Epub 2019 Oct 2.

Department of Psychiatry, Addictions Division, Centre for Addiction and Mental Health (CAMH), University of Toronto, Toronto, Ontario, Canada.

Background And Objectives: Cannabis use is common in people with and mood and anxiety disorders (ADs), and rates of problematic use are higher than in the general population. Given recent policy changes in favor of cannabis legalization, it is important to understand how cannabis and cannabinoids may impact people with these disorders. We aimed to assess the effects of cannabis on the onset and course of depression, bipolar disorder, ADs, and post-traumatic stress disorder (PTSD), and also to explore the therapeutic potential of cannabis and cannabinoids for these disorders. Read More

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http://dx.doi.org/10.1111/ajad.12963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925309PMC
January 2020
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Differential Posttreatment Outcomes of Methylphenidate for Smoking Cessation for Individuals With ADHD.

Am J Addict 2019 11 19;28(6):497-502. Epub 2019 Sep 19.

Department of Psychiatry, Division on Substance Use Disorders, Columbia University, New York, New York.

Background And Objectives: In a multisite, randomized study (CTN-0029), a 3-month course of Osmotic-Release Oral System Methylphenidate (OROS-MPH) improved smoking cessation in a group of patients with higher baseline severity in Attention-Deficit/Hyperactivity Disorder (ADHD). This treatment, however, worsened smoking cessation outcome in the group with lower baseline ADHD severity. We want to examine whether this differential treatment effect persisted after OROS-MPH was discontinued. Read More

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http://dx.doi.org/10.1111/ajad.12961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803035PMC
November 2019
4 Reads