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Am J Med Sci 2022 May 18. Epub 2022 May 18.

Department of Radiology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. Electronic address:

Am J Med Sci 2022 May 17. Epub 2022 May 17.

Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.. Electronic address:

Am J Med Sci 2022 May 17. Epub 2022 May 17.

Department of General Medicine, National Defense Medical College, Saitama, Japan. Electronic address:

Am J Med Sci 2022 May 17. Epub 2022 May 17.

Department of Radiology, Affiliated Hospital of Southwest Medical University, LuZhou, Sichuan, China. Electronic address:

Am J Med Sci 2022 May 17. Epub 2022 May 17.

Division of Cardiology Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Smoking is linked with increased risk of cardiovascular events among diabetic patients. Prediabetes is associated with increased risk for microvascular and macrovascular complications. We compared the 2-year clinical outcomes of current smoking between prediabetic and type 2 diabetes mellitus (T2DM) patients with acute myocardial infarction (AMI) after newer-generation drug-eluting stent (DES) implantation. Read More

Am J Med Sci 2022 May 16. Epub 2022 May 16.

Department of Gastroenterology, The Affiliated Hospital of Northwest University, Xi'an No.3 Hospital, Xi'an, Shaanxi, China.

Hepatic cortical blindness is an unusual clinical complication of hepatic encephalopathy, and its epidemiology has not been studied in detail. Herein, we present a case report of a 37-year-old male with liver cirrhosis and immunoglobulin A nephropathy who noted visual impairment after eating high-protein food. In addition to the case report, all previously documented cases of hepatic cortical blindness occurring across the globe published from inception until August 2019 were reviewed. Read More

Am J Med Sci 2022 May 17. Epub 2022 May 17.

Department of Ophthalmology, Centro Hospitalar e Universitário de São João; Anatomy Unit, Biomedicine Department, Faculty of Medicine of University of Porto.

Am J Med Sci 2022 May 16. Epub 2022 May 16.

Department of Pathology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033, China. Electronic address:

Background: Deep venous thrombosis (DVT) is a thrombus formed in the deep venous cavity and can cause a fatal pulmonary embolism. Since circulating miRNAs are used as molecular markers for the early warning and diagnosis of various diseases, such as tumors and cardiovascular diseases, the purpose of the present study was initially to identify differential expression circulating miRNAs in plasma, and then explore potential biomarkers for DVT.

Methods: The plasma of 30 patients with DVT before and after DVT related endovascular interventions constituted 6 sample pools for miRNA sequencing, and the levels of 22 plasma miRNAs were significantly changed. Read More

Am J Med Sci 2022 May 16. Epub 2022 May 16.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China, 266003. Electronic address:

Pulmonary artery intimal sarcomas are very rare and arise from primitive pluripotent mesenchymal cells. They are often misdiagnosed as pulmonary thromboembolism, leading to futile anticoagulation treatment and delayed diagnosis. We present a case of a patient who showed nonspecific pulmonary symptoms and characteristic imaging manifestation. Read More

Am J Med Sci 2022 May 16. Epub 2022 May 16.

Pulmonology Divison of Internal Medicine Department of Botucatu Medical School, UNESP, Botucatu, São Paulo, Brazil.

Am J Med Sci 2022 May 16. Epub 2022 May 16.

Federal University of Mato Grosso do Sul (UFMS)/Maria Aparecida Pedrossian Hospital (HUMAP). Laboratory of Respiratory Pathophysiology (LAFIR), Campo Grande, Mato Grosso do Sul, MS, Brazil. Electronic address:

Am J Med Sci 2022 May 16. Epub 2022 May 16.

Department of Hematology, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.

Am J Med Sci 2022 May 14. Epub 2022 May 14.

Immunology Division, Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt.

Background: To assess the correlation of the serum B-cell activating factor (BAFF), a proliferation-inducing ligand (APRIL) and interleukin (IL)-21 with carotid intima-media thickness (cIMT) to evaluate their efficacy as non-invasive biomarkers for the risk of premature development of atherosclerosis.

Methods: ELISA test was used to quantify serum BAFF, APRIL and IL-21 in 40 patients with SLE and 20 healthy controls (HCs). The obtained results were correlated with disease duration, anti-double stranded DNA, complement proteins levels, lipid profile, cIMT and the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Read More

Am J Med Sci 2022 May 11. Epub 2022 May 11.

Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan; Poison Center, Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan; Department of Nursing, Yuanpei University of Medical Technology, Hsinchu, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan. Electronic address:

A 69-year-old male presented to the urban medical center emergency department (ED) with the chief complaint of pain in right groin and right flank area for 2 days.  No fever, nausea, vomiting, diarrhea, constipation, gross hematuria, or dysuria were noted. Physical examination showed tenderness over the right inguinal area and right costovertebral angle. Read More

Am J Med Sci 2022 May 10. Epub 2022 May 10.

Dept of Medicine, University of Ottawa and The Ottawa Hospital. Electronic address:

Am J Med Sci 2022 May 10. Epub 2022 May 10.

Division of Chest Medicine, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, (ROC).

Am J Med Sci 2022 May 8. Epub 2022 May 8.

Pulmonology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal.

A 60-year-old man diagnosed with small cell lung cancer, stage IV, presented an excellent response after first line therapy with chemotherapy (6 cycles of Carboplatin + Etoposid), with thoracic computed tomography showing a significant shrinking of the left hilar mass, pulmonary nodules, and mediastinal adenopathies (fig.1A - before; fig.1B - after chemotherapy). Read More

Am J Med Sci 2022 May 8. Epub 2022 May 8.

Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA, 73104. Electronic address:

Synthetic cannabinoids cannot be detected on a standard urine drug screen (UDS), making them a convenient drug of abuse. We report the first case of ST elevation myocardial infarction (STEMI) in a young patient due to coronary artery thrombosis secondary to synthetic cannabinoid use and concurrent COVID-19 infection. A 38-year-old previously healthy male developed severe chest pain and was found to have anterior STEMI and COVID-19 infection. Read More

Am J Med Sci 2022 May 8. Epub 2022 May 8.

Department of Cardiology, Istanbul Medeniyet University Faculty of Medicine, Istanbul, 34722, Turkey.

Background: The tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is one of the inflammatory mediators contributing to the atherosclerotic process. TWEAK has been studied in patients with chronic kidney disease (CKD), and it has demonstrated that its level declines as estimated glomerular filtration rate (eGFR) decreases. Most studies have found that the decreased TWEAK levels were seen in atherosclerosis and associated with plaque calcification. Read More

Am J Med Sci 2022 May 8. Epub 2022 May 8.

Department of Internal Medicine, Tokyo Bay Urayasu Ichikawa Medical Center, 3-4-32, Todaijima, Urayasu, Chiba, 279-0001, Japan. Electronic address:

Am J Med Sci 2022 May 7. Epub 2022 May 7.

Department of Translational and Precision Medicine, Sapienza University of Rome. Electronic address:

The spectrum of kidney involvement in systemic sclerosis (SSc) includes scleroderma renal crisis, widely recognized as the most severe renal-vascular complication, but also several forms of chronic renal vasculopathy and reduced renal function are complications of scleroderma. Scleroderma renal crisis, myeloperoxidase-antineutrophil cytoplasmic antibody associated glomerulonephritis, penicillamine-associated renal disease, abnormal urinalysis, alteration of vascular endothelial markers, scleroderma associated-vasculopathy with abnormal renal resistance indices and cardiorenal syndromes type 5 were also reported in SSc patients. A frequent form of renal involvement in SSc patients is a subclinical renal vasculopathy, characterized by vascular damage and normal renal function. Read More

Am J Med Sci 2022 May 4. Epub 2022 May 4.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA. Electronic address:

Glucocorticoids have powerful anti-inflammatory and immunomodulatory effects, but chronic use of these drugs can cause hyperglycemia, type 2 diabetes mellitus, hepatic steatosis, obesity, and other complications due to their metabolic actions. Metformin is a widely used drug for the treatment of type 2 diabetes mellitus with a known ability to lower blood glucose levels. This review focuses on metformin's actions on glucose metabolism and its potential use as a drug to limit the metabolic side effects of glucocorticoid treatment. Read More

Am J Med Sci 2022 May 1. Epub 2022 May 1.

Sección de Estudios de posgrado, Escuela Superior de Medicina, Instituto Politécnico Nacional. Ciudad de México. Electronic address:

Background: In regards to Breast Cancer (BC), survival or disease-free periods are still compromised mainly in Triple Negative (TN) and HER2 tumors. The participation of estrogen receptor (ER) has been reported as crucial in the signaling pathways, including the NOTCH pathway. The study was aimed to evaluate the expression of NOTCH1 and NOTCH3 in BC and its relationship with the presence of ER, as well as with relapses. Read More

Am J Med Sci 2022 Apr 29. Epub 2022 Apr 29.

Division of Hospital Medicine, Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USA; Division of Hospital Internal Medicine, Department of Internal Medicine, Rochester, MN, USA. Electronic address:

Background: Identifying patients at risk for mortality from COVID-19 is crucial to triage, clinical decision-making, and the allocation of scarce hospital resources. The 4C Mortality Score effectively predicts COVID-19 mortality, but it has not been validated in a United States (U.S. Read More

Am J Med Sci 2022 Apr 29. Epub 2022 Apr 29.

Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical Universtiy, Yantai, Shandong, China. Electronic address:

Am J Med Sci 2022 Apr 28. Epub 2022 Apr 28.

University of Connecticut School of Medicine, Department of Internal Medicine, Farmington, CT, USA.

Am J Med Sci 2022 Apr 28. Epub 2022 Apr 28.

Division of Pulmonary and Critical Care Medicine, UC San Diego, La Jolla, CA, 92037, USA.

Am J Med Sci 2022 Apr 28. Epub 2022 Apr 28.

University of Alabama at Birmingham Medical Center, Birmingham, AL, USA. Electronic address:

Necrotizing sarcoid granulomatosis (NSG) is a rare disease that shares similarities with pulmonary vasculitides and sarcoidosis. This is a report of two cases of NSG with a review of literature. The first case is a 33-year-old black female with a one-year history of malaise and cough. Read More

Am J Med Sci 2022 Apr 28. Epub 2022 Apr 28.

Assistant Professor of Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, 618 Zeigler Research Building, 703 South 19th Street Birmingham, AL 35294, Phone: (205) 934-9285, Fax: (205) 996-6686. Electronic address:

Background: Emerging evidence supports the superiority of balanced crystalloids such as Lactated Ringer's (LR) compared to normal saline but concerns for the development of hyperkalemia have limited its use. Although LR inherently contains potassium, there exists a paucity of evidence to suggest that LR could potentiate hyperkalemia. To address this, we evaluated the effect of LR on serum potassium in patients with reduced kidney function who are at risk of developing hyperkalemia. Read More