7,606 results match your criteria American Journal Of Surgical Pathology[Journal]


EWSR1-NFATC2 Translocation-associated Sarcoma Clinicopathologic Findings in a Rare Aggressive Primary Bone or Soft Tissue Tumor.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Departments of Pathology.

In recent years, a novel small round cell sarcoma harboring EWSR1-NFATC2 translocation with immunomorphologic overlap with Ewing sarcoma (ES), myoepithelial tumors, and extraskeletal myxoid chondrosarcoma has emerged. There has not been a case series devoted to describing its detailed clinicopathologic and immunohistochemical characteristics. Six sarcomas harboring EWSR1-NFATC2 fusion transcripts by reverse transcription polymerase chain reaction and amplification of the fusion gene by fluorescence in situ hybridization were identified. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001260DOI Listing

Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001258DOI Listing

On Histologic Variability of HPV-associated Endocervical Adenocarcinomas.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Department of Pathology, University of British Columbia, Royal Columbian Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1097/PAS.0000000000001259DOI Listing

Validation Study of Tumor Invasive Thickness for Postoperative Prognosis in 110 Patients Who Underwent Pancreatoduodenectomy for Distal Cholangiocarcinoma at a Single Institution.

Am J Surg Pathol 2019 May;43(5):717-723

Department of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine.

The pT classification of the 8th American Joint Committee on Cancer (AJCC) for distal cholangiocarcinoma (DCC) is classified according to depth of invasion (DOI), which is the distance from the basal lamina to the most deeply advanced tumor cells. The Nagoya group proposed a new T classification for DCC based on invasive tumor thickness (ITT), which is the maximal vertical distance of the invasive cancer component (the ITT grade). In this study, we aimed to validate the ITT grade for the next pT classification of DCC in 110 patients. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001244DOI Listing

UV Signature Mutations Reclassify Salivary High-grade Neuroendocrine Carcinomas as Occult Metastatic Cutaneous Merkel Cell Carcinomas.

Am J Surg Pathol 2019 May;43(5):682-687

Departments of Pathology and Immunology.

Salivary high-grade neuroendocrine carcinomas (NECs) are rare, occur predominantly in the parotid gland, and are difficult to differentiate from metastatic cutaneous Merkel cell carcinomas (MCCs), which have overlapping morphologic, immunophenotypic, and molecular profiles. Oncogenic Merkel cell polyomavirus (MCPyV), found in 70% to 80% of MCCs, has also been reported in a few salivary NECs, but this is controversial. A promising biomarker to distinguish the 2 tumor types are UV signature mutations. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001231DOI Listing

Intraductal Oncocytic Papillary Neoplasms: Clinical-Pathologic Characterization of 24 Cases, With An Emphasis on Associated Invasive Carcinomas.

Am J Surg Pathol 2019 May;43(5):656-661

Departments of Pathology.

Background: Intraductal oncocytic papillary neoplasm (IOPN) of the pancreas is a rare tumor. Recent molecular data indicate that it is distinct from other intraductal neoplasms; however, its clinicopathologic characteristics, especially the frequency/significance of an invasive carcinoma component, and biologic behavior remain to be fully defined.

Design: Clinicopathologic characteristics and survival of 24 IOPNs were analyzed. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467507PMC
May 2019
1 Read

DICER1 and FOXL2 Mutation Status Correlates With Clinicopathologic Features in Ovarian Sertoli-Leydig Cell Tumors.

Am J Surg Pathol 2019 May;43(5):628-638

Institute of Pathology, im Medizin Campus Bodensee, Friedrichshafen, Germany.

Sertoli-Leydig cell tumors (SLCTs) are rare ovarian sex cord-stromal neoplasms. The only known recurrent genetic abnormality is DICER1 mutation, with rare mutations reported in FOXL2. We set out to establish a molecular classifier using DICER1 and FOXL2 somatic mutation status and clinicopathologic features in 42 SLCTs. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001232DOI Listing

Angiosarcoma of the Liver: Clinicopathologic Features and Morphologic Patterns.

Am J Surg Pathol 2019 May;43(5):581-590

Division of Anatomic Pathology, Mayo Clinic, Rochester, MN.

Angiosarcoma is a rare malignant neoplasm of the liver. The various morphologic patterns seen with angiosarcomas of the liver have not been systematically studied and their recognition remains a major diagnostic challenge. In order to provide more comprehensive data on the morphologic patterns, angiosarcomas that had been diagnosed between 1996 and 2016 at a large medical referral center were reviewed. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001228DOI Listing
May 2019
3 Reads

Genetic Underpinnings of Renal Cell Carcinoma With Leiomyomatous Stroma.

Am J Surg Pathol 2019 Apr 10. Epub 2019 Apr 10.

Department of Pathology, The University of Chicago, Chicago, IL.

Renal cell carcinoma (RCC) with leiomyomatous stroma is a provisional category of RCC in the 2016 World Health Organization Classification of Tumors of the Urinary System. Microscopic examination of hematoxylin and eosin-stained sections reveals this entity to be well-circumscribed with tubulopapillary growth of cells with clear cytoplasm in a background of leiomyomatous stroma. Herein we describe the genetic features of 15 University of Chicago Medical Center archived cases with hematoxylin and eosin histology matching the provisional diagnosis. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001255DOI Listing
April 2019
1 Read

Intratumoral Immune Response to Gastric Cancer Varies by Molecular and Histologic Subtype.

Am J Surg Pathol 2019 Apr 8. Epub 2019 Apr 8.

Departments of Pathology.

Immune checkpoint inhibition is effective in a subset of patients with advanced gastric cancer. Genomic profiling has revealed the heterogeneity of gastric adenocarcinomas, but the immune microenvironment and predictors of immunotherapy response remain poorly understood. We aimed to better characterize the underlying immune response to gastric cancer. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001253DOI Listing
April 2019
1 Read

Papular Mycosis Fungoides is a Distinctive Variant of Early-stage Mycosis Fungoides: Extended Retrospective Study With Long-term Follow-up.

Am J Surg Pathol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology, Research Unit Dermatopathology, Medical University of Graz, Graz, Austria.

Papular mycosis fungoides (PMF) is a rare variant of mycosis fungoides (MF). The exact nosology and prognosis of PMF are still unclear. We retrospectively identified cases of PMF from the files of the Department of Dermatology of the Medical University of Graz, Austria, and checked the follow-up data. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001256DOI Listing
April 2019
1 Read

Validation of a Congestive Hepatic Fibrosis Scoring System.

Am J Surg Pathol 2019 Apr 3. Epub 2019 Apr 3.

Departments of Pathology.

Congestive hepatopathy is a complication of right heart failure and chronically elevated right heart pressure. Histologic findings include sinusoidal dilatation, centrilobular hepatocellular plate atrophy, and fibrosis. We performed a validation study of a recently proposed scoring system (0 to 4 scale) for congestive hepatic fibrosis on 38 liver biopsies. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001250DOI Listing

Surgical Resection Margin Classifications for High-grade Pleomorphic Soft Tissue Sarcomas of the Extremity or Trunk After Neoadjuvant Cytotoxic Therapy.

Am J Surg Pathol 2019 Mar 29. Epub 2019 Mar 29.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.

Soft tissue sarcomas of the extremities or trunk are often resected after treatment with neoadjuvant radiotherapy. Adequate surgical resection margins for sarcomas after neoadjuvant cytotoxic therapy are not well characterized. Minimum surgical resection margins required for local control of primary, high-grade, pleomorphic soft tissue sarcomas treated with neoadjuvant therapy was assessed by competing risk regression in a series of 166 cases. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001246DOI Listing

Neuroendocrine Tumors (NETs) of the Minor Papilla/Ampulla: Analysis of 16 Cases Underlines Homology With Major Ampulla NETs and Differences From Extra-Ampullary Duodenal NETs.

Am J Surg Pathol 2019 Mar 25. Epub 2019 Mar 25.

Department of Molecular Medicine, Unit of Anatomic Pathology, University of Pavia.

Neuroendocrine tumors (NETs) of the minor papilla/ampulla (MIPA) are rare and poorly studied. Only individual case reports and no comprehensive analysis are available from the literature. We collected 16 MIPA NETs and investigated their clinicopathologic and immunohistochemical features, including markers such as somatostatin, pancreatic polypeptide, gastrin, serotonin, MUC1, cytokeratin 7, and somatostatin receptors type 2A and 5. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001234DOI Listing

Interobserver Agreement for Mismatch Repair Protein Immunohistochemistry in Endometrial and Nonserous, Nonmucinous Ovarian Carcinomas.

Am J Surg Pathol 2019 May;43(5):591-600

Division of Gynecologic Oncology, University Health Network/Princess Margaret Cancer Centre, Toronto.

Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is an established test to identify Lynch syndrome (LS) in patients with colorectal cancer and is being increasingly used to identify LS in women with endometrial and/or nonserous ovarian cancer (OC). We assessed interobserver agreement in the interpretation of MMR-IHC on endometrial and ovarian carcinomas. The study consisted of 73 consecutive endometrial cancers (n=48) and nonserous, nonmucinous epithelial OCs (n=25). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001220DOI Listing
May 2019
5 Reads

Micropapillary Cervical Adenocarcinoma: A Clinicopathologic Study of 44 Cases.

Am J Surg Pathol 2019 Mar 8. Epub 2019 Mar 8.

Hospital de Oncología, CMN, SXXI, Instituto Mexicano del Seguro Social.

Micropapillary adenocarcinoma has been reported as an aggressive variant of adenocarcinoma in several organs, where it is associated with poor clinical outcome. This study reports the clinicopathologic features and outcomes of cervical adenocarcinomas with a micropapillary component (micropapillary cervical adenocarcinomas); this represents the largest reported study of these neoplasms. The study comprised 44 cervical adenocarcinomas of usual (human papillomavirus-related)-type (84%), mucinous, not otherwise specified (4. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001245DOI Listing
March 2019
1 Read

Recurrent SMARCB1 Inactivation in Epithelioid Malignant Peripheral Nerve Sheath Tumors.

Am J Surg Pathol 2019 Mar 8. Epub 2019 Mar 8.

Department of Pathology.

Epithelioid malignant peripheral nerve sheath tumors (EMPNST) are characterized by diffuse S-100 and SOX10 positivity, frequent immunohistochemical loss of SMARCB1 expression (70%), and rare association with neurofibromatosis type 1. Some cases arise in a preexisting epithelioid schwannoma (ESCW), which also show SMARCB1 loss in 40% of cases. To date, little is known about the genomic landscape of this distinctive variant of malignant peripheral nerve sheath tumor. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001242DOI Listing
March 2019
4 Reads

BCOR Overexpression in Renal Malignant Solitary Fibrous Tumors: A Close Mimic of Clear Cell Sarcoma of Kidney.

Am J Surg Pathol 2019 Mar 8. Epub 2019 Mar 8.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

BCOR immunoreactivity is a sensitive and highly specific marker for clear cell sarcoma of the kidney (CCSK). However, a subset of adult renal sarcomas which overexpress BCOR are negative for BCOR genetic alterations, including BCOR gene fusions or BCOR-internal tandem duplication, and thus remain unclassified. We report 5 such undifferentiated renal/perirenal sarcomas which raised the differential diagnosis of CCSK due to their morphologic appearance and strong BCOR immunoreactivity, but which on RNA sequencing proved to be malignant solitary fibrous tumors (SFTs). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001243DOI Listing
March 2019
6 Reads
5.145 Impact Factor

Filigree-like Rete Ridges, Lobulated Nests, Rosette-like Structures, and Exaggerated Maturation Characterize Spitz Tumors With NTRK1 Fusion.

Am J Surg Pathol 2019 Mar 5. Epub 2019 Mar 5.

Departments of Dermatology and Pathology, UCSF, San Francisco, CA.

Activating NTRK1 fusions have been described as oncogenic events across the spectrum of Spitz tumors. Herein we report a series of 38 Spitz tumors with NTRK1 fusion. These Spitz tumors have distinctive histopathologic features characterized by filigree-like rete ridges which are elongated, thin and branched, dermal melanocytes arranged in a rosette-like configuration, and marked diminishment of melanocyte size with descent into the dermis. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001235DOI Listing
March 2019
1 Read

Clinicopathologic and Molecular Features of a Series of 41 Biphenotypic Sinonasal Sarcomas Expanding Their Molecular Spectrum.

Am J Surg Pathol 2019 Mar 1. Epub 2019 Mar 1.

Department of Pathology, Institut Bergonie.

Biphenotypic sinonasal sarcoma (BSNS) is a locally aggressive tumor occurring in the sinonasal region. It harbors both myogenic and neural differentiation and is characterized by PAX3 rearrangement with MAML3 as the most frequent fusion partner, but the partner of PAX3 remains unidentified in a subset of cases. About 70 cases have been reported so far. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001238DOI Listing
March 2019
4 Reads

A Proposal to Revise the Histopathologic Grading System of Early Oral Tongue Cancer Incorporating Tumor Budding.

Am J Surg Pathol 2019 May;43(5):703-709

Pathology.

The World Health Organization (WHO) grading system has a low prognostic value for early-stage oral tongue squamous cell carcinoma; greater prognostic power has been shown with tumor budding analysis. In this study, we combined tumor budding analysis with histopathologic grading according to WHO 2017. In our proposal, a revised grade I tumor is defined as a "well differentiated cohesive tumor"; revised grade II as a "moderately differentiated and/or slightly dissociated tumor"; and revised grade III as a "poorly differentiated and/or dissociated tumor. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001241DOI Listing
May 2019
5 Reads

PGR Gene Fusions Identify a Molecular Subset of Uterine Epithelioid Leiomyosarcoma With Rhabdoid Features.

Am J Surg Pathol 2019 Mar 1. Epub 2019 Mar 1.

Departments of Pathology.

Genetic aberrations among uterine epithelioid leiomyosarcomas are unknown. Following identification of an index case with NR4A3-PGR fusion demonstrating monomorphic morphologic features, we interrogated additional uterine tumors demonstrating similar histology and sought to describe the morphologic and immunohistochemical characteristics of PGR-rearranged sarcomas. Targeted next-generation RNA sequencing was performed on RNA extracted from formalin-fixed paraffin-embedded tissue of the index case. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001239DOI Listing
March 2019
7 Reads
5.145 Impact Factor

Atypical "Sclerosing" Osteoblastic Neoplasm: A Tumor of Intermediate Biological Potential Between Usual Osteoblastoma and Conventional Osteosarcoma.

Am J Surg Pathol 2019 May;43(5):610-617

Departments of Anatomic Pathology.

The existence of "aggressive" osteoblastoma (OB) or malignant transformation of OB is controversial. Over a few decades, we have encountered a group of "borderline" sclerosing osteoblastic lesions that are difficult to classify, tending toward local recurrence, especially following curettage. A search of the consultative and institutional files from 3 co-authors for atypical OB, malignant transformation of OB, well-differentiated osteosarcoma (OS), and OB-like OS diagnoses revealed 8 similar cases. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001236DOI Listing
May 2019
3 Reads

Intracholecystic Papillary Neoplasms are Distinct From Papillary Gallbladder Cancers: A Clinicopathologic and Exome-sequencing Study.

Am J Surg Pathol 2019 Feb 21. Epub 2019 Feb 21.

Departments of Diagnostic Pathology.

Although intracholecystic papillary neoplasms (ICPNs) have been increasingly recognized, their features remain unclear because of the lack of standardized definition. This study aimed to elucidate clinicopathologic and genetic features of ICPNs using stringent diagnostic criteria. On the basis of the recently proposed criteria, gallbladder neoplasms showing delicate papillary growth were diagnosed as ICPNs, while polypoid papillary adenocarcinomas arranged in a complex architecture were categorized as papillary gallbladder cancers (GBCs). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001237DOI Listing
February 2019
1 Read

Cellular Dissociation Grading Based on the Parameters Tumor Budding and Cell Nest Size in Pretherapeutic Biopsy Specimens Allows for Prognostic Patient Stratification in Esophageal Squamous Cell Carcinoma Independent From Clinical Staging.

Am J Surg Pathol 2019 May;43(5):618-627

Institute of Pathology.

Initial treatment planning in esophageal squamous cell carcinoma mainly relies on clinical staging. Recently, a highly prognostic grading system based on the cellular dissociation parameters Tumor Budding and Cell Nest Size has been proposed for resected esophageal squamous cell carcinoma. To probe for the transferability and relevance of this established novel grading system in the pretreatment setting, we evaluated Tumor Budding/Cell Nest Size in pretherapeutic biopsies of either primarily resected (cohort 1, n=80) or neoadjuvantly treated (cohort 2, n=75) esophageal squamous cell carcinoma. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001230DOI Listing
May 2019
3 Reads

Undifferentiated Uterine Sarcomas Represent Under-Recognized High-grade Endometrial Stromal Sarcomas.

Am J Surg Pathol 2019 May;43(5):662-669

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Undifferentiated uterine sarcoma is a diagnosis of exclusion with limited molecular genetic data available. Recent recognition of high-grade endometrial stromal sarcomas with diverse genotypes suggests that some tumors classified as undifferentiated uterine sarcomas may represent misdiagnosed high-grade endometrial stromal sarcomas. Archival material from 10 tumors diagnosed as undifferentiated uterine sarcomas in 2009 to 2017 were collected. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001215DOI Listing
May 2019
4 Reads

Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall.

Am J Surg Pathol 2019 May;43(5):601-609

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Myoepithelial carcinoma (MECA) is an underrecognized challenging entity with a broad morphologic spectrum. Misinterpreting MECA is not uncommon as distinguishing it from its mimics, especially cellular myoepithelial-rich pleomorphic adenoma (PA), can be difficult. We described 21 histologically challenging cases of MECAs (16 MECA ex-PA and 5 MECA de novo). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001218DOI Listing
May 2019
1 Read

SOX11-negative Mantle Cell Lymphoma: Clinicopathologic and Prognostic Features of 75 Patients.

Am J Surg Pathol 2019 May;43(5):710-716

Departments of Hematopathology.

Studies have suggested that SOX11 expression has prognostic implications in patients with mantle cell lymphoma (MCL), but the data are controversial. In this study, we describe the clinicopathologic and prognostic features of 75 patients with SOX11-negative MCL. Compared with patients with SOX11-positive MCL, SOX11-negative MCL patients more frequently had leukemic non-nodal disease (21% vs. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001233DOI Listing
May 2019
1 Read

George M. Farrow, MD: A Tribute.

Am J Surg Pathol 2019 Mar;43(3):432-433

Division of Anatomic Pathology, Rochester, MN.

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http://dx.doi.org/10.1097/PAS.0000000000000942DOI Listing

Prospective Detection of Germline Mutation of Fumarate Hydratase in Women With Uterine Smooth Muscle Tumors Using Pathology-based Screening to Trigger Genetic Counseling for Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome: A 5-Year Single Institutional Experience.

Am J Surg Pathol 2019 May;43(5):639-655

Pathology Department, University of California San Francisco.

Pathology-based screening of uterine smooth muscle tumors (uSMT) for morphology suggestive of fumarate hydratase deficiency (FH-d morphology) has been proposed as a method to identify women at increased risk for hereditary leiomyomatosis renal cell carcinoma (HLRCC) syndrome. For 5 years our clinical diagnostic practice has evaluated all women with any type of uSMT for FH-d morphology (defined, at low magnification, as staghorn shaped blood vessels and alveolar pattern edema and, at high magnification, as tumor macronucleoli surrounded by a halo and cytoplasmic eosinophilic globules) and, when present, used the pathology report to advise genetic counseling to further evaluate for HLRCC syndrome. We now report the results of this prospective screening strategy, with emphasis on the incidence and clinicopathologic features of FH-d morphology in uSMT, the rate of patient uptake of referral to genetic counseling, and the results of genetic testing for FH germline mutation. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001222DOI Listing
May 2019
1 Read

90Y-TheraSpheres: The New Look of Yttrium-90.

Am J Surg Pathol 2019 May;43(5):688-694

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD.

Selective internal radiation therapy with Y-TheraSphere or Y-SIRSphere is used in the treatment of unresectable hepatic malignancies. To the best of our knowledge, this is the first Y-TheraSpheres series. BTG International Canada Inc. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001223DOI Listing

Expanding the Spectrum of Intraosseous Rhabdomyosarcoma: Correlation Between 2 Distinct Gene Fusions and Phenotype.

Am J Surg Pathol 2019 May;43(5):695-702

Departments of Pathology.

Primary intraosseous rhabdomyosarcomas (RMSs) are extremely rare. Recently 2 studies reported 4 cases of primary intraosseous RMS with EWSR1/FUS-TFCP2 gene fusions, associated with somewhat conflicting histologic features, ranging from spindle to epithelioid. In this study we sought to further investigate the pathologic and molecular abnormalities of a larger group of intraosseous RMSs by a combined approach using targeted RNA sequencing analysis and fluorescence in situ hybridization (FISH). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001227DOI Listing
May 2019
2 Reads
5.145 Impact Factor

Clinical Outcomes of HPV-associated and Unassociated Endocervical Adenocarcinomas Categorized by the International Endocervical Adenocarcinoma Criteria and Classification (IECC).

Am J Surg Pathol 2019 Apr;43(4):466-474

Departments of Pathology.

The International Endocervical Adenocarcinoma Criteria and Classification (IECC) categorizes endocervical adenocarcinomas (ECAs) on the basis of morphologic features linked to etiology (ie, human papilloma virus [HPV] infection), resulting in separation of ECAs into HPV-associated (HPVA) and unassociated or non-HPVA (NHPVA) types. NHPVAs are reported to be large and present at high stage in older individuals. Our aim was to examine the clinical outcomes in these tumor types. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417947PMC
April 2019
6 Reads

Impact of Peritoneal Metastasis on Survival of Patients With Small Intestinal Neuroendocrine Tumor.

Am J Surg Pathol 2019 Apr;43(4):559-563

Departments of Pathology, Microbiology, and Immunology.

The liver and peritoneum are the 2 most common distant metastatic sites for small intestinal neuroendocrine tumors (SI-NET). In this study, we evaluated the differential impact of hepatic and/or peritoneal metastasis on prognosis of SI-NET patients. Surgical Pathology archives were searched for SI-NET resections performed between January 1, 1994 and August 31, 2017. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417938PMC
April 2019
1 Read

Adenocarcinoma of the Rete Testis: Clinicopathologic and Immunohistochemical Characterization of 6 Cases and Review of the Literature.

Am J Surg Pathol 2019 May;43(5):670-681

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

Adenocarcinoma of the rete testis is rare and its etiological and pathologic characteristics are not well studied. We therefore investigated the clinical, morphologic, and immunohistochemical features of 6 cases diagnosed at our institution and conducted a detailed review of the literature. The mean age was 64 years. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001219DOI Listing
May 2019
12 Reads

Intrasinusoidal Spread of Hepatic Epithelioid Hemangioendothelioma: Implications for the Diagnosis in Minimal Samples.

Am J Surg Pathol 2019 Apr;43(4):573-579

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY.

Epithelioid hemangioendothelioma (EHE) is an angiocentric tumor that, when arising in liver, is centered around hepatic/portal veins. However, EHE cells can also track along sinusoids, which is not well recognized or studied. We identified 18 cases of hepatic EHE and 6 nonhepatic EHEs. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001221DOI Listing
April 2019
1 Read

Activating Structural Alterations in MAPK Genes Are Distinct Genetic Drivers in a Unique Subgroup Of Spitzoid Neoplasms.

Am J Surg Pathol 2019 Apr;43(4):538-548

Departments of Dermatology.

Recent studies have described kinase fusions as the most common initiating genomic events in Spitzoid neoplasms. Each rearrangement generates a chimeric protein with constitutive activation of the tyrosine kinase domain, resulting in the development of a Spitzoid neoplasm. Identifying key initiating genomic events and drivers may assist in diagnosis, prognostication, and management. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001213DOI Listing
April 2019
10 Reads

SOX10, GATA3, GCDFP15, Androgen Receptor, and Mammaglobin for the Differential Diagnosis Between Triple-negative Breast Cancer and TTF1-negative Lung Adenocarcinoma.

Am J Surg Pathol 2019 Mar;43(3):293-302

Departments of Biopathology.

Triple-negative breast cancer (TNBC) patients have an increased risk of developing visceral metastases and other primary nonbreast cancers, particularly lung cancer. The differential diagnosis of TNBC metastases and primary cancers from other organs can be difficult due to lack of a TNBC standard immunoprofile. We analyzed the diagnostic value of estrogen receptor, progesterone receptor, human epidermal growth factor receptor, thyroid transcription factor-1 (TTF1), Napsin A, mammaglobin, gross cystic disease fluid protein 15 (GCDFP15), Sry-related HMg-Box gene 10 (SOX10), GATA-binding protein 3 (GATA3), and androgen receptor in a series of 207 TNBC and 152 primary lung adenocarcinomas (LA). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001216DOI Listing
March 2019
1 Read

Histologic Response to Neoadjuvant Therapy Is Not Predictive of Favorable Outcomes in High-grade Pleomorphic Soft Tissue Sarcoma.

Authors:
Justin M M Cates

Am J Surg Pathol 2019 Apr;43(4):564-572

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN.

The College of American Pathologists recommends reporting the histologic response of soft tissue sarcomas (STS) to neoadjuvant therapy, presumably as an assessment of chemosensitivity and a prognostic indicator, despite lack of evidence of clinical utility as such. This study examines whether extent of neoadjuvant therapy effect in STS is a favorable prognostic factor for disease-free survival. Extent of tumor necrosis and stromal hyalinization/fibrosis were determined in 143 high-grade, nonmetastatic, pleomorphic STS of the extremity or trunk. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001214DOI Listing
April 2019
2 Reads

Napsin A, Hepatocyte Nuclear Factor-1-Beta (HNF-1β), Estrogen and Progesterone Receptors Expression in Arias-Stella Reaction.

Am J Surg Pathol 2019 Mar;43(3):325-333

Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.

Background: The Arias-Stella reaction (ASR) can mimic endometrial clear cell carcinoma (ECCC) in small biopsies, especially when drug or pregnancy history is unknown. A panel of immunohistochemical markers comprising napsin A, hepatocyte nuclear factor-1-beta (HNF-1β), estrogen and progesterone receptors (ER, PR) has been found useful in confirming a diagnosis of ECCC. However, the detailed characterization of how expression of this combination of markers in the ECCC mimics ASR has yet to be thoroughly evaluated. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001212DOI Listing
March 2019
5 Reads

De Novo Testicular Extranodal NK/T-Cell Lymphoma: A Clinicopathologic Study of 21 Cases With Review of Additional 18 Cases in the Literature.

Am J Surg Pathol 2019 Apr;43(4):549-558

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine.

Although the testis is not uncommonly involved during the course of disease in both nasal and non-nasal extranodal NK/T-cell lymphoma (ENKTCL), only a few cases presenting initially with a testicular mass have been previously reported. These have been documented as case reports, rather than as study series. Because of its rarity, the clinicopathologic features and the prognosis of de novo testicular ENKTCL have not been well characterized. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001210DOI Listing
April 2019
2 Reads

Targeted Molecular and Immunohistochemical Analyses of Endometrial Clear Cell Carcinoma Show that POLE Mutations and DNA Mismatch Repair Protein Deficiencies Are Uncommon.

Am J Surg Pathol 2019 Apr;43(4):531-537

Department of Laboratory Medicine and Pathology, University of Saskatchewan, Saskatoon, SK.

Endometrial clear cell carcinoma (ECCC) is an uncommon histotype without unique identified molecular alterations. Recently, The Cancer Genome Atlas molecular subtypes have been reported in ECCC. ECCC cases were collected from 11 institutions with diagnoses confirmed by morphologic review and immunohistochemistry. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001209DOI Listing
April 2019
7 Reads

SSTR2a Is a Useful Diagnostic Marker for Follicular Dendritic Cells and Their Related Tumors.

Am J Surg Pathol 2019 Mar;43(3):374-381

Department of Pathology, Peking University Shenzhen Hospital, Shenzhen.

SSTR2a, a member of the somatostatin receptor family, has been used as a diagnostic marker of meningioma. However, the expression of SSTR2a in follicular dendritic cells (FDCs) and their related tumors has been poorly characterized. This study aimed to assess the potential diagnostic utility of measuring SSTR2a immunohistochemically in FDCs and their related tumors. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001205DOI Listing
March 2019
4 Reads

Expanding the Spectrum of Pediatric NTRK-rearranged Mesenchymal Tumors.

Am J Surg Pathol 2019 Apr;43(4):435-445

Department of Laboratories, Seattle Children's Hospital, Seattle, WA.

Pediatric mesenchymal tumors harboring variant NTRK fusions (ETV6-negative) are being increasingly described; however, the histologic and clinical features of these variant NTRK tumors and their relationship to classic infantile fibrosarcoma are not well characterized. A better understanding of the clinicopathologic features of these tumors is necessary, and would aid in both early diagnosis and treatment. Therefore, the aim of this study was to characterize a series of pediatric NTRK-rearranged mesenchymal tumors, including classic ETV6-NTRK3 fused tumors and tumors with variant (non-ETV6) NTRK fusions. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001203DOI Listing
April 2019
3 Reads

PRDM10-rearranged Soft Tissue Tumor: A Clinicopathologic Study of 9 Cases.

Am J Surg Pathol 2019 Apr;43(4):504-513

Department of Clinical Genetics and Pathology, University and Regional Laboratories, Skåne University Hospital, Lund University.

Gene fusion transcripts containing PRDM10 were recently identified in low-grade undifferentiated pleomorphic sarcomas (UPS). Here, we describe the morphologic and clinical features of 9 such tumors from 5 men and 4 women (age: 20 to 61 y). Three cases had previously been diagnosed as UPS, 3 as superficial CD34-positive fibroblastic tumor (SCD34FT), 2 as pleomorphic liposarcoma, and 1 as pleomorphic hyalinizing angiectatic tumor. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001207DOI Listing
April 2019
29 Reads

A Comprehensive Analysis of the Association Between Gleason Score at a Positive Surgical Margin and the Risk of Biochemical Recurrence After Radical Prostatectomy.

Am J Surg Pathol 2019 Mar;43(3):369-373

Departments of Urology.

Our objective was to identify the best of the existing definitions of Gleason score (GS) at a positive surgical margin (PSM) by validating them in our radical prostatectomy cohort. We analyzed 251 patients who had mixed (3+4, 3+5, 4+3 or 5+3) pathologic GS and PSM. We used 5 definitions to record GS at a PSM. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001204DOI Listing
March 2019
10 Reads

Clinicopathologic and Molecular Features of Metastatic Follicular Thyroid Carcinoma in Patients Presenting With a Thyroid Nodule Versus a Distant Metastasis.

Am J Surg Pathol 2019 Apr;43(4):514-522

Department of Pathology, University of Chicago Medical Center.

Metastatic follicular thyroid carcinoma (FTC) is rare. The aim of this study was to determine the clinical, histologic, and molecular differences between patients with metastatic FTC who present with distant metastatic (DM) disease versus those who present with a primary thyroid nodule (PT). Clinical and pathologic information was extracted from the medical record and surgical pathology report. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001208DOI Listing
April 2019
4 Reads