Am J Reprod Immunol 2021 Apr 9:e13428. Epub 2021 Apr 9.
Los Angeles County + University of Southern California Medical Center and Keck School of Medicine of the University of Southern California, Division of Rheumatology, Department of Medicine, Los Angeles, CA, USA.
Problem: Immunologic, angiogenic, and anti-angiogenic factors are associated with spontaneous abortion (SAB). B-cell activating factor (BAFF), a proliferation-inducing ligand (APRIL), placental growth factor (PlGF), and soluble fms-like tyrosine kinase-1 (sFlt-1) may play a role in SAB and may serve singly or in combination as an early biomarker of SAB.
Method Of Study: In this prospective observational study, serum sFlt-1, PIGF, BAFF, and APRIL levels were measured in the first trimester of pregnancy in a medically-diverse group of women and in non-pregnant controls. Read More