10,232 results match your criteria American Journal Of Physiology-heart And Circulatory Physiology[Journal]


Lysyl oxidase-like 2 (LOXL2) depletion is protective in age-associated vascular stiffening.

Am J Physiol Heart Circ Physiol 2019 Apr 19. Epub 2019 Apr 19.

ACCM, Johns Hopkins University, United States.

Vascular stiffening and its sequelae are major causes of morbidity and mortality in the elderly. The increasingly accepted concept of "smooth muscle cell (SMC) stiffness syndrome" along with matrix deposition has emerged in vascular biology to account for the mechanical phenotype of arterial aging, but the molecular targets remain elusive. In this study, using an unbiased proteomic analysis, we identified lysyl oxidase-like 2 (LOXL2) as a critical SMC mediator for age-associated vascular stiffening. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00670.2018
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http://dx.doi.org/10.1152/ajpheart.00670.2018DOI Listing
April 2019
1 Read

Chemotherapy acutely impairs neurovascular and hemodynamic responses in women with breast cancer.

Am J Physiol Heart Circ Physiol 2019 Apr 19. Epub 2019 Apr 19.

Unid Reabilit Cardiovasc e Fisiol do Exerc, Heart Institute (InCor), University of Sao Paulo Medical School and School of Physical Education and Sport, University of Sao Paulo, Brazil.

Aims: To test if doxorubicin (DX) and cyclophosphamide (CY) adjuvant chemotherapy (CHT) acutely impairs neurovascular and hemodynamic responses in women with breast cancer.

Methods: Sixteen women (age:47.0±2. Read More

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http://dx.doi.org/10.1152/ajpheart.00756.2018DOI Listing

Heat therapy vs. supervised exercise therapy for peripheral arterial disease: a 12-week randomized, controlled trial.

Am J Physiol Heart Circ Physiol 2019 Apr 19. Epub 2019 Apr 19.

School of Physical Education, Sport and Exercise Sciences, University of Otago, New Zealand.

Peripheral arterial disease (PAD) is characterized by lower limb atherosclerosis impairing blood supply and causing walking-induced leg pain, or claudication. Adherence to traditional exercise training programs is poor due to these symptoms, despite exercise being a mainstay of conservative treatment. Heat therapy improves many cardiovascular health outcomes, so this study tested if this was a viable alternative cardiovascular therapy for PAD patients. Read More

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http://dx.doi.org/10.1152/ajpheart.00151.2019DOI Listing

Myocardial ischemia - lack of coronary blood flow, myocardial oxygen supply-demand imbalance or what ?

Authors:
Gerd Heusch

Am J Physiol Heart Circ Physiol 2019 Apr 19. Epub 2019 Apr 19.

Institut fur Pathophysiologie, Universitatsklinikum Essen, Germany.

This opinionated article reviews current concepts of myocardial ischemia. Specifically, the historical background is briefly presented. Then the prevailing paradigm of myocardial oxygen-supply-demand imbalance is criticized since demand is a virtual parameter which cannot be measured and data on measurements of myocardial blood flow and contractile function rather support matching between flow and function. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00139.2019
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http://dx.doi.org/10.1152/ajpheart.00139.2019DOI Listing
April 2019
1 Read

Treatment with apolipoprotein A1 protects mice against doxorubicin-induced cardiotoxicity in a scavenger receptor class B type I dependent manner.

Am J Physiol Heart Circ Physiol 2019 Apr 19. Epub 2019 Apr 19.

Biochemistry and Biomedical Sciences; and Thrombosis and Atherosclerosis Research Institute, McMaster University, Canada.

Doxorubicin, an agent used to treat a variety of cancers, is cardiotoxic by triggering cardiomyocyte apoptosis. We previously showed that treating cultured cardiomyocytes with human high density lipoprotein in vitro or transgenic overexpression of human apolipoprotein A1, its main structural protein protects against doxorubicin induced cardiomyocyte apoptosis in a manner dependent on the scavenger receptor class B type I [Durham (2018) 314: H31-H44]. This was due to high density lipoprotein induced activation of Akt signaling in cardiomyocytes. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00432.2018
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http://dx.doi.org/10.1152/ajpheart.00432.2018DOI Listing
April 2019
1 Read

Coagulopathy implications using a multiscale model of traumatic bleeding matching macro and microcirculation.

Am J Physiol Heart Circ Physiol 2019 Apr 12. Epub 2019 Apr 12.

University of Pennsylvania, 394 Town Building, United States.

Quantifying the relationship between vascular injury and the dynamic bleeding rate requires a multiscale model that accounts for changing and coupled hemodynamics between the global and microvascular levels. A lumped, global hemodynamic model of the human cardiovascular system with baroreflex control was coupled to a local 24-level bifurcating vascular network that spanned diameters from the muscular artery scale (0.1 - 1. Read More

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http://dx.doi.org/10.1152/ajpheart.00774.2018DOI Listing
April 2019
1 Read

Effects of High-Intensity Interval Training on Microvascular Glycocalyx and Associated microRNAs.

Am J Physiol Heart Circ Physiol 2019 Apr 12. Epub 2019 Apr 12.

Molecular Genetics of Cardiovascular Research, Leibniz-Institute for Arteriosclerosis Research.

High-intensity interval training (HIIT) has been proposed to exert vasculoprotective effects. This study aimed to evaluate if HIIT affects the microvasculature including the endothelial glycocalyx barrier and to identify associated microRNAs (miRNAs). Fifty healthy participants (23. Read More

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http://dx.doi.org/10.1152/ajpheart.00751.2018DOI Listing
April 2019
1 Read

Direct CD137 costimulation of CD8 T cells promotes retention and innate-like function within nascent atherogenic foci.

Am J Physiol Heart Circ Physiol 2019 Apr 12. Epub 2019 Apr 12.

Immunology, University of Connecticut Health, United States.

Effector CD8 T cells infiltrate atherosclerotic lesions and are correlated with cardiovascular events, but the mechanisms regulating their recruitment and retention are not well-understood. CD137 (4-1BB) is a costimulatory receptor induced on immune cells and expressed at sites of human atherosclerotic plaque. Genetic variants associated with decreased CD137 expression correlate with carotid-intimal thickness and its deficiency in animal models attenuates atherosclerosis. Read More

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http://dx.doi.org/10.1152/ajpheart.00088.2019DOI Listing

Mitochondrial Angiotensin Receptors and Cardioprotective Pathways.

Am J Physiol Heart Circ Physiol 2019 Apr 12. Epub 2019 Apr 12.

Physiology, University of Puerto Rico School of Medicine, United States.

A growing body of data provides strong evidence that intracellular angiotensin II (Ang II) plays an important role in mammalian cell function and is involved in the pathogenesis of human diseases such hypertension, diabetes, inflammation, fibrosis, arrhythmias, and kidney disease, among others. Recent studies also suggest that intracellular Ang II exert protective effects in cells during high extracellular levels of the hormone or during chronic stimulation of local tissue renin-angiotensin system (RAS). Notably, the intracellular RAS (iRAS) described in neurons, fibroblasts, renal cells, and cardiomyocytes, have provided new insights into regulatory mechanisms mediated by intracellular Ang II type 1 (AT1-Rs) and 2 receptors (AT2-Rs), particularly, in mitochondria and nucleus. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00772.2018
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http://dx.doi.org/10.1152/ajpheart.00772.2018DOI Listing
April 2019
3 Reads
3.838 Impact Factor

A novel method optimizing the normalization of cardiac parameters in small animal models: the importance of dimensional indexing.

Am J Physiol Heart Circ Physiol 2019 Apr 12. Epub 2019 Apr 12.

Pediatric Cardiology-Center for Congenital Heart Diseases, University Medical Center Groningen-GUIDE.

Aims: For indexing cardiac measures in small animal models, tibia length (TL) is a recommended surrogate for body weight (BW) that aims to avoid biases due to disease-induced BW changes. However, we question if indexing by TL is mathematically correct. This study aimed to investigate the relation between TL and BW, heart weight, ventricular weights and left ventricular diameter to optimize the current common practice of indexing cardiac parameters in small animal models. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00182.2019
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http://dx.doi.org/10.1152/ajpheart.00182.2019DOI Listing
April 2019
3 Reads

Left Ventricular and Proximal Aorta Coupling in Magnetic Resonance Imaging: Aging Together?

Am J Physiol Heart Circ Physiol 2019 Apr 12. Epub 2019 Apr 12.

Division of cardiology, Johns Hopkins University, School of Medicine.

Background: The importance of aorta-ventricular coupling in cardiovascular disease is recognized but underestimated. The contribution of the age-related decline in ascending aortic function in comparison to characteristic impedance and total peripheral resistance on left ventricular function and remodeling is poorly studied. Our aim was to evaluate the relation of proximal aortic distensibility and impedance with left ventricular geometry and function in asymptomatic individuals. Read More

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http://dx.doi.org/10.1152/ajpheart.00694.2018DOI Listing

Corrigendum.

Authors:

Am J Physiol Heart Circ Physiol 2019 Apr;316(4):H939

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http://dx.doi.org/10.1152/ajpheart.zh4-2748-corr.2019DOI Listing

Central ANG-(1-7) Infusion Improves Blood Pressure Regulation in Antenatal Betamethasone-Exposed Sheep and Reveals Sex Dependent Effects on Oxidative Stress.

Am J Physiol Heart Circ Physiol 2019 Apr 5. Epub 2019 Apr 5.

Hypertension and Vascular Research Center, Wake Forest University School of Medicine, United States.

Fetal exposure to betamethasone (BMX) as a consequence of glucocorticoid administration to women threatening premature delivery may lead to long-term deleterious effects on the cardiovascular system and dysregulation of blood pressure in exposed adults. In an experimental model, adult offspring of BMX sheep exhibit increased mean arterial pressure (MAP) and attenuated baroreflex sensitivity (BRS) that is associated with lower medullary and cerebrospinal fluid (CSF) angiotensin-(1-7) [(Ang-(1-7)] content. Thus, we determined the effects of Ang-(1-7) supplementation on MAP, BRS, blood pressure (BPV) and heart rate variability (HRV) in conscious animals by continuous infusion of the peptide into the lateral ventricle of 4 month-old male and female BMX sheep for 2 weeks. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00497.2018
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http://dx.doi.org/10.1152/ajpheart.00497.2018DOI Listing
April 2019
3 Reads

A Novel Traditional Chinese Medicine ameliorates fatigue-induced cardiac hypertrophy and dysfunction via regulation of energy metabolism.

Am J Physiol Heart Circ Physiol 2019 Apr 5. Epub 2019 Apr 5.

Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, China.

Aims:Prolonged exercise and exercise training can adversely affect cardiac function in some individuals. QiShenYiQi Pills® (QSYQ), a compound Chinese medicine,has been previously shown to improve pressure overload-induced cardiac hypertrophy. We hypothesized that QSYQ can ameliorate as well the fatigue-induced cardiac hypertrophy. Read More

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http://dx.doi.org/10.1152/ajpheart.00731.2018DOI Listing
April 2019
1 Read

CYP4A/20-HETE Regulates Ischemia-induced Neovascularization via Its Actions on Endothelial Progenitor and Preexisting Endothelial Cells.

Am J Physiol Heart Circ Physiol 2019 Apr 5. Epub 2019 Apr 5.

Pharmacology, New York Medical College, United States.

20-hydroxyeicosatetraenoic acid (20-HETE) was recently identified as a novel contributor of ischemia-induced neovascularization based on the key observation that pharmacological interferences of CYP4A/20-HETE decrease ischemic neovascularization. The objective of the present study is to examine whether the underlying cellular mechanisms involve endothelial progenitor cells (EPC) and pre-existing endothelial cells (EC). We found that ischemia leads to a time-dependent increase of cyp4a12 expression and 20-HETE production that are endothelial in origin using immunofluorescent (IF) microscopy, western blot analysis, and LC/MS/MS. Read More

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http://dx.doi.org/10.1152/ajpheart.00690.2018DOI Listing
April 2019
2 Reads

Epigenetic Regulation of Intercellular Communication in the Heart.

Am J Physiol Heart Circ Physiol 2019 Apr 5. Epub 2019 Apr 5.

University Antwerpen.

The myocardium is a highly structured tissue consisting of different cell types including cardiomyocytes, endothelial cells, fibroblasts, smooth muscle cells, inflammatory cells, and stem cells. Microvascular endothelial cells are the most abundant cell type in the myocardium and play crucial roles during cardiac development, in normal adult myocardium, and during myocardial diseases such as heart failure. In the last decade, epigenetic changes have been described regulating cellular function in almost every cell type in the organism. Read More

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http://dx.doi.org/10.1152/ajpheart.00038.2019DOI Listing
April 2019
2 Reads

Knockdown of CD44 Expression Decreases Valve Interstitial Cell Calcification in Vitro.

Am J Physiol Heart Circ Physiol 2019 Apr 5. Epub 2019 Apr 5.

Department of Biomedical Engineering, Tufts University, United States.

Objective: The lack of pharmaceutical targets available to treat patients with calcific aortic valve disease (CAVD) necessitates further research into the specific mechanisms of the disease. The significant changes that occur to the aortic valves extracellular matrix (ECM) during the progression of CAVD suggests that these proteins may play an important role in calcification. Exploring the relationship between valve interstitial cells and the ECM may lead to a better understand of CAVD mechanisms and potential pharmaceutical targets. Read More

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http://dx.doi.org/10.1152/ajpheart.00123.2018DOI Listing

Heart Rate Fragmentation: Using Cardiac Pacemaker Dynamics to Probe the Pace of Biologic Aging.

Am J Physiol Heart Circ Physiol 2019 Apr 5. Epub 2019 Apr 5.

Medicine, HARVARD MEDICAL SCHOOL/BETH ISRAEL DEACONESS MEDICAL CENTER, United States.

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http://dx.doi.org/10.1152/ajpheart.00110.2019DOI Listing

Corrigendum.

Authors:

Am J Physiol Heart Circ Physiol 2019 Apr;316(4):H938

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http://dx.doi.org/10.1152/ajpheart.zh4-2716-corr.2019DOI Listing

Reply to Angé et al.

Am J Physiol Heart Circ Physiol 2019 Apr;316(4):H936-H937

Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio.

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http://dx.doi.org/10.1152/ajpheart.00095.2019DOI Listing

Role of AMP-activated protein kinase in sepsis-induced cardiovascular dysfunction.

Am J Physiol Heart Circ Physiol 2019 Apr;316(4):H934-H935

Pole de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, UCLouvain, Brussels , Belgium.

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http://dx.doi.org/10.1152/ajpheart.00015.2019DOI Listing
April 2019
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The (Pro)renin Receptor Knockdown in the Paraventricular Nucleus of Hypothalamus Attenuates Hypertension Development and AT Receptor-Mediated Calcium Events.

Am J Physiol Heart Circ Physiol 2019 Mar 29. Epub 2019 Mar 29.

Pharmacology and Physiology & Cell Biology, University of Nevada, Reno, United States.

Activation of the brain renin-angiotensin system (RAS) is a pivotal step in the pathogenesis of hypertension. The paraventricular nucleus (PVN) of the hypothalamus is a critical part of the angiotensinergic sympatho-excitatory neuronal network involved in neural control of blood pressure and hypertension. However, the importance of the PVN (pro)renin receptor (PVN-PRR)-a key component of the brain RAS-in hypertension development has not been examined. Read More

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http://dx.doi.org/10.1152/ajpheart.00780.2018DOI Listing
March 2019
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Apoptosis signal-regulating kinase 1 activation by Nox1-derived oxidants is required for TNFα receptor endocytosis.

Am J Physiol Heart Circ Physiol 2019 Mar 29. Epub 2019 Mar 29.

Pediatrics, Vanderbilt Childrens Hospital, United States.

Tumor necrosis factor-α (TNFα) is pro-inflammatory cytokine that is closely linked to the development of cardiovascular disease. TNFα activates NADPH oxidase 1 (Nox1), and reactive oxygen species (ROS) including superoxide (O) production extracellularly are required for subsequent signaling in vascular smooth muscle cells (VSMC). Apoptosis signal-regulating kinase 1 (ASK1) is a MAPKKK that is activated by oxidation of associated thioredoxin. Read More

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http://dx.doi.org/10.1152/ajpheart.00741.2018DOI Listing
March 2019
1 Read

Activated T effector seeds: Cultivating atherosclerotic plaque through alternative activation.

Am J Physiol Heart Circ Physiol 2019 Mar 29. Epub 2019 Mar 29.

Immunology, University of Connecticut Health, United States.

Atherosclerosis is a chronic inflammatory pathology that precipitates substantial morbidity and mortality. Though initiated by physiologic patterns of low and disturbed flow that differentially prime endothelial cells at sites of vessel branch points and curvature, the chronic, smoldering inflammation of atherosclerosis is accelerated by comorbidities involving inappropriate activation of the adaptive immune system, such as autoimmunity. The innate contributions to atherosclerosis, especially in the transition of monocyte to lipid laden macrophage is well-established, but the mechanisms underpinning the infiltration, persistence, and effector dynamics of CD8 T cells in particular, are not well understood. Read More

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http://dx.doi.org/10.1152/ajpheart.00148.2019DOI Listing
March 2019
1 Read

Strength-Duration Relationship as a Tool to Prioritize Cardiac Tissue Properties that Govern Electrical Excitability.

Am J Physiol Heart Circ Physiol 2019 Mar 29. Epub 2019 Mar 29.

Depts. of Biomedical Engineering and Pediatrics, Emory University, United States.

Engineered cardiac tissue and cardiomyocyte cell cultures offer wide opportunities for improved therapeutic intervention and laboratory heart models. Electric field excitation is a common intervention in the production of engineered tissue and the investigation of the electrical properties of in vitro cell cultures. In this work, we use strength-duration relationships to systematically investigate factors influencing electrical excitability of 2D and 3D neonatal rat ventricular myocyte cultures. Read More

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http://dx.doi.org/10.1152/ajpheart.00161.2019DOI Listing
March 2019
3.838 Impact Factor

Hydrogen sulfide-mediated regulation of cell death signaling ameliorates adverse cardiac remodeling and diabetic cardiomyopathy.

Am J Physiol Heart Circ Physiol 2019 Mar 29. Epub 2019 Mar 29.

Cellular and Integrative Physiology, University of Nebraska Medical Center, United States.

The death of cardiomyocytes is a precursor for the cascade of hypertrophic and fibrotic remodeling that leads to cardiomyopathy. In diabetes mellitus (DM), the metabolic environment of hyperglycemia, hyperlipidemia, and oxidative stress causes cardiomyocyte cell death leading to diabetic cardiomyopathy (DMCM), an independent cause of heart failure. Understanding the roles of the cell death signaling pathways involved in the development of cardiomyopathies is crucial to the discovery of novel targeted therapeutics and biomarkers for DMCM. Read More

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http://dx.doi.org/10.1152/ajpheart.00004.2019DOI Listing
March 2019
2 Reads

Transient inhibition of neddylation at neonatal stage evokes reversible cardiomyopathy and predisposes the heart to isoproterenol-induced heart failure.

Am J Physiol Heart Circ Physiol 2019 Mar 29. Epub 2019 Mar 29.

Vascular Biology Center, Augusta University, United States.

Alterations in perinatal conditions (such as preterm birth) is linked to adult health and disease, in particular, the cardiovascular system. Neddylation, a novel post-translational modification through which the ubiquitin-like protein NEDD8 is conjugated to protein substrates, has emerged as an important mechanism regulating embryonic cardiac chamber maturation. However, the importance of neddylation in postpartum cardiac development has not been investigated. Read More

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http://dx.doi.org/10.1152/ajpheart.00806.2018DOI Listing
March 2019
1 Read
3.838 Impact Factor

Maternal High-Fat, High-Sucrose Diet Induces Transgenerational Cardiac Mitochondrial Dysfunction Independent of Maternal Mitochondrial Inheritance.

Am J Physiol Heart Circ Physiol 2019 Mar 22. Epub 2019 Mar 22.

Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University in St. Louis, United States.

Maternal obesity is correlated with cardiovascular disease in offspring, with 1.3-fold increase in events observed in offspring of obese women. We have observed that obesity-exposed oocytes demonstrate impaired mitophagy and transmit damaged mitochondria to the offspring. Read More

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http://dx.doi.org/10.1152/ajpheart.00013.2019DOI Listing
March 2019
2 Reads

MK5 haplodeficiency decreases collagen deposition and scar size during post-myocardial infarction wound repair.

Am J Physiol Heart Circ Physiol 2019 Mar 22. Epub 2019 Mar 22.

Research Center, Montreal Heart Institute, Canada.

MK5 is a protein serine/threonine kinase activated by p38, ERK3, and ERK4 MAPKs. MK5 mRNA and immunoreactivity are detected in mouse cardiac fibroblasts and MK5-haplodeficiency attenuates the increase in collagen 1-a1 mRNA evoked by pressure overload. The present study examined the effect of MK5 haplodeficiency on reparative fibrosis following myocardial infarction (MI). Read More

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http://dx.doi.org/10.1152/ajpheart.00532.2017DOI Listing
March 2019
2 Reads
3.838 Impact Factor

Vascular phenotype of amyloid precursor protein-deficient mice.

Am J Physiol Heart Circ Physiol 2019 Mar 22. Epub 2019 Mar 22.

Department of Anesthesiology, Mayo Clinic, United States.

The amyloid precursor protein (APP) is expressed in blood vessel wall but the physiological function of APP is not completely understood. Moreover, previous studies established that APP has amine oxidase activity responsible for degradation of catecholamines. In the present study, we characterized vascular phenotype of APP-knockout (APP) mice. Read More

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http://dx.doi.org/10.1152/ajpheart.00539.2018DOI Listing
March 2019
1 Read

Role of T-cell Activation in Salt-sensitive Hypertension.

Am J Physiol Heart Circ Physiol 2019 Mar 22. Epub 2019 Mar 22.

Medicine, Duke University, United States.

The contributions of T lymphocytes to the pathogenesis of salt-sensitive hypertension has been well established. Under hypertensive stimuli, naïve T cells develop into different subsets, including Th1, Th2, Th17, Treg and cytotoxic CD8 T cells, depending on the surrounding microenviroment in organs. Distinct subsets of T cells may play totally different roles in tissue damage and hypertension. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00096.2019
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http://dx.doi.org/10.1152/ajpheart.00096.2019DOI Listing
March 2019
7 Reads

Novel approach for quantification of endoplasmic reticulum Ca transport.

Am J Physiol Heart Circ Physiol 2019 Mar 22. Epub 2019 Mar 22.

Cell and Molecular Physiology, Loyola University Chicago, United States.

The type 2a sarco/endoplasmic reticulum Ca-ATPase (SERCA2a) plays a key role in Ca regulation in the heart. However, available techniques to study SERCA function are either cell destructive or lack sensitivity. The goal of this study was to develop an approach to selectively measure SERCA2a function in the cellular environment. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00031.2019
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http://dx.doi.org/10.1152/ajpheart.00031.2019DOI Listing
March 2019
8 Reads

Ablation of Cardiac TIGAR Preserves Myocardial Energetics and Cardiac Function in the Pressure Overload Heart Failure Model.

Am J Physiol Heart Circ Physiol 2019 Mar 22. Epub 2019 Mar 22.

Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan.

Despite the advances in medical therapy, the morbidity and mortality of heart failure (HF) remain unacceptably high. HF results from reduced metabolism-contraction coupling efficiency, so the modulation of cardiac metabolism may be an effective strategy for therapeutic interventions. Tumor suppressor p53 and its downstream target TP53-induced glycolysis and apoptosis regulator (TIGAR) are known to modulate cardiac metabolism and cell fate. Read More

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http://dx.doi.org/10.1152/ajpheart.00395.2018DOI Listing

Understanding Sex Differences in Long-term Blood Pressure Regulation: Insights from Experimental Studies and Computational Modeling.

Am J Physiol Heart Circ Physiol 2019 Mar 15. Epub 2019 Mar 15.

Department of Applied Mathematics, University of Waterloo, United States.

Sex differences in blood pressure and the prevalence of hypertension are found in humans and animal models. Moreover, there has been a recent an explosion of data concerning sex differences in nitric oxide, the renin-angiotensin-aldosterone system, inflammation, and kidney function. These data have the potential to reveal the mechanisms underlying male-female differences in blood pressure control. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00035.2019
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http://dx.doi.org/10.1152/ajpheart.00035.2019DOI Listing
March 2019
1 Read

Shaping the future heart: transgenerational outcomes of maternal metabolic syndrome.

Am J Physiol Heart Circ Physiol 2019 Mar 15. Epub 2019 Mar 15.

Pediatrics, Nationwide Childrens Hospital and Ohio State University, United States.

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http://dx.doi.org/10.1152/ajpheart.00156.2019DOI Listing
March 2019
1 Read
3.838 Impact Factor

Conduction in the Right and Left Ventricle is Differentially Regulated by Protein Kinases and Phosphatases: Implications for Arrhythmogenesis.

Am J Physiol Heart Circ Physiol 2019 Mar 15. Epub 2019 Mar 15.

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, United States.

The "stress kinases" cAMP-dependent protein kinase (PKA) and calcium/calmodulin-dependent protein kinase II (CaMKII), phosphorylate the Nachannel Nav1.5 subunit to regulate its function. However, how the channel regulation translates to ventricular conduction is poorly understood. Read More

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http://dx.doi.org/10.1152/ajpheart.00660.2018DOI Listing
March 2019
1 Read

Zebrafish model of amyloid light chain cardiotoxicity: regeneration vs degeneration.

Am J Physiol Heart Circ Physiol 2019 Mar 15. Epub 2019 Mar 15.

Medicine, Stanford Cardiovascular Institute, United States.

Cardiac dysfunction is the most frequent cause of morbidity and mortality in immunoglobulin light chain (AL) amyloidosis. Previously published transgenic animal models of AL amyloidosis have not recapitulated the key phenotype of cardiac dysfunction seen in AL amyloidosis which has limited our understanding of the disease mechanisms in vivo, as well as the development of targeted AL therapeutics. We have developed a transgenic zebrafish model in which a AL patient-derived lambda light chain (LC) is conditionally expressed in the liver under the control of UAS-Gal4 enhancer system. Read More

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http://dx.doi.org/10.1152/ajpheart.00788.2018DOI Listing

Right Ventricular and Pulmonary Vascular Changes in Pulmonary Hypertension Associated with Left Heart Disease.

Am J Physiol Heart Circ Physiol 2019 Mar 15. Epub 2019 Mar 15.

Johns Hopkins Medical Institutions, United States.

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http://dx.doi.org/10.1152/ajpheart.00159.2019DOI Listing
March 2019
1 Read

Development of a decerebrate model for investigating mechanisms mediating viscero-sympathetic reflexes in the spinalized rat.

Am J Physiol Heart Circ Physiol 2019 Mar 15. Epub 2019 Mar 15.

Emergency Medicine, Wayne State University School of Medicine, United States.

Autonomic dysreflexia (AD) often occurs in individuals living with spinal cord injury (SCI) and is characterized by uncontrolled hypertension in response to otherwise innocuous stimuli originating below the level of the spinal lesion. Visceral stimulation is a predominate cause of AD in humans, and effectively replicates the phenotype in rodent models of SCI. Direct assessment of sympathetic responses to viscerosensory stimulation in spinalized animals is challenging and requires invasive surgical procedures necessitating the use of anesthesia. Read More

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http://dx.doi.org/10.1152/ajpheart.00724.2018DOI Listing
March 2019
1 Read

Role of endothelial NAD+ deficiency in age-related vascular dysfunction.

Am J Physiol Heart Circ Physiol 2019 Mar 15. Epub 2019 Mar 15.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, United States.

Age-related alterations in endothelium and the resulting vascular dysfunction critically contribute to a range of pathological conditions associated with old age. To rationally develop therapies that improve vascular health and thereby increase health span and lifespan in older adults, it will be essential to understand the cellular and molecular mechanisms contributing to vascular aging. Pre-clinical studies in model organisms demonstrate that NAD availability decreases with age in multiple tissues and that supplemental NAD precursors can ameliorate many age-related cellular impairments. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00039.2019
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http://dx.doi.org/10.1152/ajpheart.00039.2019DOI Listing
March 2019
4 Reads

Hemodynamic characterization of a transgenic rat strain stably expressing the calcium sensor protein GCaMP2.

Am J Physiol Heart Circ Physiol 2019 Mar 15. Epub 2019 Mar 15.

University of Heidelberg, Germany.

A novel transgenic rat strain has recently been generated that stably expresses the genetically engineered calcium sensor protein GCaMP2 in different cell types including cardiomyocytes to investigate calcium homeostasis. In order to investigate whether the expression of the GCaMP2 protein itself affects cardiac function, in the present work we aimed at characterizing in vivo hemodynamics in the GCaMP2 transgenic rat strain. GCaMP2 transgenic rats and age-matched Sprague-Dawley control animals were investigated. Read More

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http://dx.doi.org/10.1152/ajpheart.00074.2019DOI Listing
March 2019
2 Reads

Mapping Genetic Modifiers of Radiation-Induced Cardiotoxicity to Rat Chromosome 3.

Am J Physiol Heart Circ Physiol 2019 Mar 8. Epub 2019 Mar 8.

Radiation Oncology, Medical College of Wisconsin, United States.

Radiation therapy is used in ~50% of cancer patients to reduce the risk of recurrence and in some cases improve survival. Despite these benefits, doses can be limited by toxicity in multiple organs, including the heart. The underlying causes and biomarkers of radiation-induced cardiotoxicity are currently unknown, prompting the need for experimental models with inherent differences in sensitivity and resistance to the development of radiation-induced cardiotoxicity. Read More

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http://dx.doi.org/10.1152/ajpheart.00482.2018DOI Listing
March 2019
2 Reads

Hypoxia-Inducible Factor 1 (HIF-1) regulates SERCA2 in the heart by modulating miR-29c levels.

Am J Physiol Heart Circ Physiol 2019 Mar 8. Epub 2019 Mar 8.

Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Canada.

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http://dx.doi.org/10.1152/ajpheart.00019.2019DOI Listing
March 2019
2 Reads

ENDOPLASMIC RETICULUM STRESS INHIBITION BLUNTS THE DEVELOPMENT OF ESSENTIAL HYPERTENSION IN THE SPONTANEOUSLY HYPERTENSIVE RAT.

Am J Physiol Heart Circ Physiol 2019 Mar 8. Epub 2019 Mar 8.

Medicine, McMaster University and St Joseph's Healthcare Hamilton, Canada.

Essential hypertension is the leading cause of premature death worldwide. However, hypertension's cause remains uncertain. Endoplasmic reticulum (ER) stress has recently been associated with hypertension, but it is unclear whether ER stress causes hypertension. Read More

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http://dx.doi.org/10.1152/ajpheart.00523.2018DOI Listing

Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment.

Am J Physiol Heart Circ Physiol 2019 Mar 8. Epub 2019 Mar 8.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, United States.

There has been an increasing appreciation of role of vascular contributions to cognitive impairment and dementia (VCID) associated with old age. Strong preclinical and translational evidence links age-related dysfunction and structural alterations of the cerebral arteries, arterioles and capillaries to the pathogenesis of many types of dementia in the elderly, including Alzheimer's disease. The low pressure, low velocity and large volume venous circulation of the brain also plays critical roles in the maintenance of homeostasis in the central nervous system. Read More

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http://dx.doi.org/10.1152/ajpheart.00776.2018DOI Listing
March 2019
1 Read

Extracellular histones induce calcium signals in the endothelium of resistance-sized mesenteric arteries and cause loss of endothelium-dependent dilation.

Am J Physiol Heart Circ Physiol 2019 Mar 8. Epub 2019 Mar 8.

Surgery, University of Vermont, United States.

Histone proteins are elevated in the circulation after traumatic injury owing to cellular lysis and release from neutrophils. Elevated circulating histones in trauma contribute to coagulopathy and mortality through a mechanism suspected to involve endothelial cell (EC) dysfunction. However, the functional consequences of histone exposure on intact blood vessels are unknown. Read More

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http://dx.doi.org/10.1152/ajpheart.00655.2018DOI Listing
March 2019
2 Reads

Corrigendum.

Authors:

Am J Physiol Heart Circ Physiol 2019 Mar;316(3):H762-H763

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http://dx.doi.org/10.1152/ajpheart.zh4-2706-corr-2019DOI Listing

Angiotensin Type 2 Receptor Stimulation With Compound 21 Improves Neurological Function after Stroke In Female Rats: A Pilot Study.

Am J Physiol Heart Circ Physiol 2019 Mar 1. Epub 2019 Mar 1.

UGA, United States.

The angiotensin II type 2 receptor (AT2R) agonist, compound 21 (C21), has been shown to be neurovascular protective after ischemic stroke in male rats. In the current study, we aim to study the impact of C21 treatment on female rats. Young female Wistar rats were subjected to different durations of middle cerebral artery occlusion (MCAO) (3 h, 2 h and 1 h) using a silicone-coated monofilament, treated at reperfusion with Intraperitoneal C21 0. Read More

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http://dx.doi.org/10.1152/ajpheart.00446.2018DOI Listing
March 2019
3.838 Impact Factor

Muscle Metaboreflex - Induced Central Blood Volume Mobilization in Heart Failure.

Am J Physiol Heart Circ Physiol 2019 Mar 1. Epub 2019 Mar 1.

Dept of Biomedical Sciences, Edward Via College of Osteopathic Medicine-Carolinas Campus, United States.

Underperfusion of active skeletal muscle causes metabolites to accumulate and stimulate group III and IV skeletal muscle afferents which triggers a powerful pressor response termed the muscle metaboreflex. Muscle metaboreflex activation (MMA) during submaximal dynamic exercise in healthy individuals increases arterial pressure mainly via substantial increases in cardiac output (CO). The increases in CO occur via the combination of tachycardia and increased ventricular contractility. Read More

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http://dx.doi.org/10.1152/ajpheart.00805.2018DOI Listing
March 2019
6 Reads

Beneficial effects of mesenchymal stem cell delivery via a novel cardiac bioscaffold on right ventricles of pulmonary arterial hypertensive rats.

Am J Physiol Heart Circ Physiol 2019 May 1;316(5):H1005-H1013. Epub 2019 Mar 1.

Department of Biomedical Engineering, University of Wisconsin , Madison, Wisconsin.

Right ventricular failure (RVF) is a common cause of death in patients suffering from pulmonary arterial hypertension (PAH). The current treatment for PAH only moderately improves symptoms, and RVF ultimately occurs. Therefore, it is necessary to develop new treatment strategies to protect against right ventricle (RV) maladaptation despite PAH progression. Read More

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http://dx.doi.org/10.1152/ajpheart.00091.2018DOI Listing
May 2019
4 Reads