Am J Physiol Lung Cell Mol Physiol 2022 May 3. Epub 2022 May 3.
ndiana University School of Medicine, Department of Medicine, Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Indianapolis, IN, United States.
In patients with sickle cell disease (SCD), acute chest syndrome (ACS) is a major cause of morbidity and mortality. The pathophysiology of ACS is complex and hemin, the prosthetic moiety of hemoglobin, has been implicated in endothelial cell (EC) activation and subsequent ALI and ACS in vitro and in animal studies. Here, we examined the role of cortactin (CTTN), a cytoskeletal protein that regulates EC function, in response to hemin-induced ALI and ACS. Read More