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Am J Otolaryngol 2022 May 19;43(4):103508. Epub 2022 May 19.

Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, PA, USA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Introduction: Radiofrequency ablation (RFA) has gained significant recent global interest in the treatment of benign thyroid nodules and thyroid cancer. It is a relatively new, minimally invasive, thermal ablation technique that is an alternative to surgery. Several clinical practice guidelines (CPGs), consensus statements, and recommendations currently exist for the use of RFA in the treatment of benign thyroid nodules and thyroid cancers. Read More

Am J Otolaryngol 2022 May 20;43(4):103511. Epub 2022 May 20.

Case Western Reserve University School of Medicine, Cleveland, OH, USA; Department of Otolaryngology-Head & Neck Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Objective: To analyze the prognostic significance of microscopic vs macroscopic extranodal extension and to assess the impact of chemoradiation on overall survival among patients with oral cavity squamous cell carcinoma and varying degrees of extranodal extension.

Methods: Utilizing the National Cancer Database, we performed a retrospective cohort study of 7975 patients with oral cavity squamous cell carcinoma and varying degrees of extranodal extension who underwent primary surgical intervention. Propensity-score matched models following Cox regression analyses allowed us to assess the impact of adjuvant radiation alone vs adjuvant chemoradiation on overall survival in patients with microscopic extranodal extension and macroscopic extranodal extension. Read More

Am J Otolaryngol 2022 May 17:103506. Epub 2022 May 17.

Intensive Care Unit, Hospital Morales Meseguer, Murcia, Spain.

Am J Otolaryngol 2022 May 16;43(4):103504. Epub 2022 May 16.

Department of Neuroscience, Audiology Unit, University of Padova, Treviso, Italy.

Purpose: Otitis media with effusion (OME) is the most common ear disease in childhood. The hearing loss associated with OME impacts on children's language development and behavior. Eustachian tube insufflation are among possible treatments for OME, but data regarding their effectiveness are scarce. Read More

Am J Otolaryngol 2022 May 7;43(4):103475. Epub 2022 May 7.

Department of Otorhinolaryngology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Objective: Septorhinoplasty is the most frequently performed aesthetic operation. Many techniques are used in septorhinoplasty, and these techniques can affect patient satisfaction, which is one of the most important parameters showing success in surgery. In this study, we aimed to compare the postoperative satisfaction of patients with and without crushed cartilage onlay grafts. Read More

Am J Otolaryngol 2022 May 13:103495. Epub 2022 May 13.

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN, United States of America; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States of America. Electronic address:

Medical education is rapidly evolving. The historical reliance on textbook reading is being increasingly replaced by trainees in favor of using non-traditional platforms such as podcasts, videos, and app-based learning. Neuroscience research on human learning has demonstrated superior long-term retention when the synergistic principles of spaced repetition and active recall are employed. Read More

Am J Otolaryngol 2022 Apr 5;43(4):103443. Epub 2022 Apr 5.

Department of Otolaryngology - Head and Neck Surgery, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.

Purpose: Head and neck cancer patients require close clinical follow up to monitor and address sequelae of treatment and for adequate cancer surveillance. The goal of this study is to determine barriers and risk factors for head and neck cancer patients who are lost-to-follow-up.

Materials And Methods: A chart review of the Head and Neck Cancer Registry was performed to identify patients who were lost-to-follow-up (LTF). Read More

Am J Otolaryngol 2022 May 4;43(4):103483. Epub 2022 May 4.

Thomas Jefferson University Hospital, Department of Otolaryngology-Head and Neck Surgery, 925 Chestnut St, Philadelphia, PA 19107, United States of America.

Objective: To compare the experiences of patients who received sialendoscopy under general anesthesia (GA) with those who received monitored anesthesia care (MAC).

Methods: Patients who underwent sialendoscopy for sialadenitis or sialolithiasis from July 1, 2020, to July 31, 2021, were offered inclusion to this prospective observational study. A survey was sent to consenting patients on post-operative day 1 to record aspects of their pre-, intra-, and post-operative experience. Read More

Am J Otolaryngol 2022 Apr 9;43(4):103469. Epub 2022 Apr 9.

Head and Neck Institute, Cleveland Clinic, Cleveland, OH, United States of America. Electronic address:

Objective: The rationale of the study was to examine the association between chronic rhinosinusitis (CRS) and COVID-19 hospitalization.

Study Design: Retrospective cohort study.

Setting: Cleveland Clinic hospital inpatient and outpatient. Read More

Am J Otolaryngol 2022 May 5:103490. Epub 2022 May 5.

Department of Otolaryngology-Head and Neck Surgery at the University of Pennsylvania, United States of America.

Objective: To present a case of a ballistic foreign body in the pharynx after a gunshot wound to the maxillofacial area, an accompanying review of relevant literature, and our approach to management.

Method: A 68-year-old male with no prior medical history presented to our trauma center with gunshot wounds to the left chin, left wrist, right chest, and sternum. A CT Angiogram of the neck revealed a bullet fragment left neck and additional fragment adjacent to the L hypopharynx at the level of the hyoid. Read More

Am J Otolaryngol 2022 May 6;43(4):103487. Epub 2022 May 6.

The University of Mississippi Medical Center, Department of Otolaryngology, Head and Neck Surgery, 2500 North State St., Jackson, MS 39216, United States of America. Electronic address:

Objective: The purpose of this report is to describe a case of bilateral cochlear implantation (CI) in a pediatric patient with Chudley-McCullough Syndrome (CMS). By reviewing the literature, we hope to describe common clinical presentations to aid in early diagnosis and management of pediatric patients with CMS.

Methods: Case report with literature review. Read More

Am J Otolaryngol 2022 May 5;43(4):103489. Epub 2022 May 5.

Department of Otolaryngology, School of Medicine, University of Florida, Gainesville, FL, United States of America.

Am J Otolaryngol 2022 May 4;43(4):103482. Epub 2022 May 4.

Department of Otolaryngology Head and Neck Surgery, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing 100048, China.

Background: Although there are many treatments for laryngeal contact granuloma (LCG), some patients still fail treatment. Botulinum toxin A injection vocal cords may be a salvage therapy.

Objectives: To study the efficacy of thyroarytenoid botulinum toxin A injection for the treatment of refractory LCG. Read More

Am J Otolaryngol 2022 May 4;43(4):103491. Epub 2022 May 4.

Department of Otolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, IL, United States of America.

Objectives: This study used the National Cancer Database to determine the effect of human papillomavirus (HPV) on survival outcomes for recurrent oropharyngeal cancer treated with salvage surgery after initial treatment with radiation therapy or chemoradiation therapy.

Methods: Patients with recurrent oropharyngeal cancer receiving salvage surgery after initial treatment with adjuvant therapy were identified through the National Cancer Database. Demographics, tumor characteristics, and survival data were collected. Read More

Am J Otolaryngol 2022 May 5;43(4):103485. Epub 2022 May 5.

ENT Department, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.

Purpose: ANCA-associated vasculitides (AAV) represent a group of diagnoses, including granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA) and microscopic polyangiitis (MPA). Most commonly, they present initially with ENT-associated symptomatology, and therefore they often pose a diagnostic challenge. We aim to present our one-year experience in the joint management of AAV in a multi-disciplinary setting. Read More

Am J Otolaryngol 2022 May 4;43(4):103476. Epub 2022 May 4.

Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Preoperative corticosteroids have been shown to improve surgical visibility and intraoperative blood loss for chronic rhinosinusitis with nasal polyposis (CRSwNP) patients undergoing endoscopic sinus surgery (ESS). However, there is no consensus on the optimal dosing regimen.

Methods: A randomized, controlled trial was conducted to compare low, medium, and high dose corticosteroids prior to ESS. Read More

Am J Otolaryngol 2022 May 6;43(4):103474. Epub 2022 May 6.

Vestibology & ENT Unit, Giovanni Paolo II Hospital, Policoro, Matera, Italy.

Purpose: The diagnosis of benign paroxysmal positional vertigo (BPPV) involving the posterior semicircular canal (PSC) is traditionally entrusted to positioning tests where patients are rapidly brought in the supine position. This prospective study aims to define the role of a diagnostic protocol for PSC-BPPV including only upright tests.

Materials And Methods: 109 patients with PSC-BPPV were enrolled. Read More

Am J Otolaryngol 2022 May 5;43(4):103478. Epub 2022 May 5.

Otorhinolaryngology Research Center, Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Guilan University of Medical Sciences, Amiralmomenin Hospital, Rasht, Iran. Electronic address:

Purpose: Chronic Rhinosinusitis (CRS) can be accompanied by asthma and, rarely by chronic obstructive pulmonary disease (COPD). Functional endoscopic sinus surgery (FESS) is the most common surgical approach for CRS which also improves asthma symptoms, but little is known about its effects on COPD. This study investigates the effects of FESS on COPD and asthma symptoms in CRS patients referred to a university hospital in northern Iran. Read More

Am J Otolaryngol 2022 May 6:103481. Epub 2022 May 6.

Bezmialem Vakif University, Faculty of Medicine, Department of Otorhinolaryngology, Fatih, Istanbul, Turkey.

Objective: The aim of this study is to demonstrate a new surgical technique to achieve ideal nasal tip rotation and projection with nasal supratip angle in patients with thick skin.

Method: Supratip suture and skin scoring technique was used in 24 patients who underwent open technique septorhinoplasty operation between the years 2019 and 2022. In this technique the nose skin was thinned with scissors. Read More

Am J Otolaryngol 2022 May 6:103486. Epub 2022 May 6.

Division of Otorhinolaryngology, Department of Surgery, Dentistry, Gynecology, and Pediatrics, University of Verona, University Hospital of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy.

Am J Otolaryngol 2022 May 4;43(4):103477. Epub 2022 May 4.

Department of Basic Oncology, Dokuz Eylul University Institute of Oncology, Izmir, Turkey.

Objectives: This study aimed to examine the relationship between checkpoint receptors (PD-1, PD-L1, PD-L2, CTLA-4) and lymphoid infiltration level (TILs) with prognostic features of patients with laryngeal squamous cell carcinoma (LSCC).

Methods: A retrospective study was designed at a tertiary referential university hospital between April 2008 and December 2020. The surgical specimen of the patients who met the eligibility criteria were re-examined histopathological, sociodemographic, clinical, pathological, and follow-up findings of patients were determined. Read More

Am J Otolaryngol 2022 May 4;43(4):103488. Epub 2022 May 4.

Dept of Otolaryngology Head and Neck Surgery, Flinders Medical Centre, South Australia, Australia; College of Medicine and Public Health, Flinders University, South Australia, Australia.

Aims: The incidence of epistaxis-related admissions amongst elderly patients is rising due to the increasing use of anticoagulants and antiplatelet agents. This retrospective study evaluates the differences in outcomes for patients on warfarin, novel anticoagulants (NOACs) and antiplatelets over two different time periods.

Methodology: Retrospective case-control study with data from patients admitted with epistaxis through the Flinders Medical Centre Emergency Department in the first six months of 2013 and compared to the same period in 2018. Read More

Am J Otolaryngol 2022 May 5;43(4):103480. Epub 2022 May 5.

Unit of Otorhinolaringology, Department of Biomedicine, Neuroscience and Advanced Diagnostics, AOUP Paolo Giaccone, University of Palermo, Via del Vespro, 133, 90127 Palermo, Italy.

Background: The relationship between nasal functions and middle ear surgery is still under debate. Nasal obstruction is considered as a negative prognostic factor in middle ear surgery. This is based on the theory that it may cause Eustachian tube dysfunction (ETD) by leading to reduced ventilation of the middle ear, as found in several patients with nasal septal deviation, chronic rhinitis and nasal polyps. Read More

Am J Otolaryngol 2022 May 4;43(4):103484. Epub 2022 May 4.

College of Nursing and Health Professions, School of Speech and Hearing Sciences, J.B. George Building, University of Southern Mississippi, Hattiesburg, MS, USA. Electronic address:

Background: This study compared distortion product otoacoustic emissions (DPOAEs) and click-evoked auditory brainstem responses (ABRs) recorded from infants whose mother had Covid-19 during pregnancy (Covid-19 group) to infants whose mother did not have Covid-19 (Control group) during pregnancy.

Methods: This study retrospectively examined records of infants in the Covid-19 group (n = 15) and control group (n = 46) who had distortion product otoacoustic emissions (DPOAEs) and click-evoked auditory brainstem responses (ABRs) recorded as part of their clinical assessment. DPOAE amplitudes, absolute latencies (I, III, and V), and I-V interpeak intervals were examined. Read More

Am J Otolaryngol 2022 May 4;43(4):103479. Epub 2022 May 4.

Department of Anesthesiology, Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Purpose: Difficult laryngeal exposure during laryngeal microsurgery and laser surgery is a major concern for otolaryngologists. This study evaluated the efficacy and safety of magnesium sulfate administration in difficult laryngeal exposure patients.

Study Design: Quasi-experimental design. Read More

Am J Otolaryngol 2022 May 2;43(4):103472. Epub 2022 May 2.

Otorhinolaryngology Research Center, Department of Otolaryngology-Head and Neck Surgery, Amir Alam Hospital, Tehran University of Medical Sciences, North Saadi Ave., Tehran 11457-65111, Iran. Electronic address:

Objective: To evaluate iatrogenic facial nerve injury in mastoidectomy and its paralysis improvement result after nerve injury management.

Methods: A retrospective review of medical records of 21 patients with iatrogenic facial nerve injury following mastoidectomy who underwent nerve injury management in a tertiary referral center.

Results: There were nine males and 12 females, with a mean age of 40. Read More

Am J Otolaryngol 2022 May 2;43(4):103473. Epub 2022 May 2.

HUS Joint Resources, Helsinki University Hospital and University of Helsinki, Finland.

Purpose: Lateral nasal wall insufficiency has previously been a surgical challenge. In 2018, the Alar Nasal Valve Stent (Medtronic) was taken into use at Helsinki University Hospital. The alar cartilages are repositioned and locked into position with the Alar Nasal Valve Stent on the mucosa. Read More

Am J Otolaryngol 2022 May-Jun;43(3):103201. Epub 2021 Sep 10.

Department of Otolaryngology, Renqiu People's Hospital, Renqiu, Hebei, China.

Objective: The current study was conducted aimed at investigating the effect of stellate ganglion injection guided with different approaches on hearing threshold in patients harboring sudden deafness.

Methods: There involved a total of 68 patients with sudden deafness in our study. The patients were randomly allocated into control group and study group, with 34 cases in each group. Read More

Am J Otolaryngol 2022 May-Jun;43(3):103438. Epub 2022 Apr 6.

Boston Medical Center, Boston University School of Medicine, Department of Radiation Oncology, Boston, MA, United States. Electronic address:

Purpose: To evaluate the impact of hospital safety-net burden and social demographics on the overall survival of patients with oral cavity squamous cell carcinoma.

Materials And Methods: We identified 48,176 oral cancer patients diagnosed between the years 2004 to 2015 from the National Cancer Database and categorized treatment facilities as no, low, or high safety-net burden hospitals based on the percentage of uninsured or Medicaid patients treated. Using the Kaplan Meier method and multivariate analysis, we examined the effect of hospital safety-net burden, sociodemographic variables, and clinical factors on overall survival. Read More

Am J Otolaryngol 2022 May-Jun;43(3):103445. Epub 2022 Apr 8.

Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy; Biomedical Science PhD School, Biomedical Science Department, University of Sassari, Italy.