27,156 results match your criteria American Journal Of Ophthalmology[Journal]


Masquerading Superior Oblique Palsy.

Am J Ophthalmol 2022 May 23. Epub 2022 May 23.

Department of Ophthalmology.

Purpose: We evaluated patients with hypertropia compatible with diagnosis of superior oblique (SO) palsy to ascertain if the 3-step test (3ST) can distinguish SO atrophy characteristic of trochlear nerve pathology from masquerading conditions.

Design: Prospective cross-sectional study.

Methods: In an academic practice, we performed quasi-coronal plane, surface coil magnetic resonance imaging in 83 patients clinically diagnosed with SO palsy. Read More

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Osteo-odonto-keratoprosthesis according to Strampelli original technique: A retrospective study with up to 30 years of follow-up.

Am J Ophthalmol 2022 May 23. Epub 2022 May 23.

Department of Odontostomatologic and Maxillofacial Sciences, Head and Neck Department, Sapienza University of Rome, Italy.

Purpose: To describe clinical, anatomical, and visual outcomes obtained from a long-term follow-up of 59 patients who underwent osteo-odonto-keratoprosthesis (OOKP) using the original Strampelli technique.

Design: retrospective clinical cohort study.

Methods: 82 eyes of 59 patients who underwent OOKP surgery between 1969 and 2011 were included. Read More

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Gender Representation Among Presenters in Ophthalmology Subspecialties in 2019: A Retrospective Review.

Am J Ophthalmol 2022 May 23. Epub 2022 May 23.

University of Utah Health John A Moran Eye Center, Salt Lake City, Utah, United States.

Purpose: To describe gender representation at eight national ophthalmology conferences, stratified by role, session category, and sub-specialty.

Design: Retrospective cross-sectional study.

Study Population: 3,817 presenters at the 2019 American Academy of Ophthalmology subspecialty days, American Society of Cataract and Refractive Surgery, American Glaucoma Society, American Society of Retina Specialists, American Society of Ophthalmic Plastic and Reconstructive Surgery, American Association for Pediatric Ophthalmology and Strabismus, North American Neuro-Ophthalmology Society, and American Uveitis Society meetings. Read More

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Clinical and Demographic Profile of Uveal Coloboma: A hospital-based Study of 14,371 eyes of 9557 Indian Patients.

Am J Ophthalmol 2022 May 22. Epub 2022 May 22.

Retina and Vitreous Services, L V Prasad Eye Institute, Patia, Bhubaneswar, India.

Objective: To describe the demographics and clinical profile of uveal coloboma in patients presenting to a multi-tier ophthalmology hospital network in India.

Design: Cross- sectional hospital -based study.

Methods: This cross-sectional hospital-based study included 2,817,766 new patients presenting between August 2010 and May 2021. Read More

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Retinal Detachments Associated with Topical Pilocarpine Use for Presbyopia: Pilocarpine-Associated Retinal Detachments.

Am J Ophthalmol 2022 May 21. Epub 2022 May 21.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL 33136. Electronic address:

Purpose: To present a case series of retinal detachments associated with the use of pilocarpine for presbyopia.

Design: Multicenter case series of 3 eyes from 2 patients.

Results: Patient 1, a 47-year-old male, presented with flashes and floaters in both eyes. Read More

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COVID-19 vaccination hesitancy and its association with altered presentation of primary rhegmatogenous retinal detachment.

Am J Ophthalmol 2022 May 21. Epub 2022 May 21.

Department of Ophthalmology & Visual Neurosciences, University of Minnesota Medical School, Minneapolis, MN, USA; VitreoRetinal Surgery, P.L.L.C., Minneapolis, MN, USA. Electronic address:

Purpose: Evaluate factors associated with coronavirus 2019 (COVID-19) vaccine hesitancy and clinical trends in primary rhegmatogenous retinal detachments (RRD) during first year of vaccine availability.

Design: Single-center, clinical cohort study METHODS: : Consecutive patients from December 14, 2020 to December 12, 2021 presenting vaccinated (Prior-), subsequently vaccinated (Later-), or remaining unvaccinated (Never-Vax). Primary outcome was proportion with macula-off (mac-off) RRD. Read More

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Quantification of Anterior Chamber Cells in Children with Uveitis Using Anterior Segment Optical Coherence Tomography.

Am J Ophthalmol 2022 May 21. Epub 2022 May 21.

Ocular Inflammatory Disease Center, UCLA Stein Eye Institute.

Purpose: To evaluate the feasibility of anterior segment optical coherence tomography (AS-OCT) for measuring anterior chamber (AC) cells in children with uveitis and to compare different AS-OCT acquisition modes.

Design: Validity and reliability analysis.

Methods: We enrolled children younger than 18 years of age who had uveitis involving the anterior segment and children without eye disease as controls. Read More

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Evaluation of Subretinal fluid Drainage Techniques during Pars Plana Vitrectomy for Primary Rhegmatogenous Retinal Detachment - ELLIPSOID study.

Am J Ophthalmol 2022 May 18. Epub 2022 May 18.

Department of Ophthalmology and Vision Sciences, University of Toronto, CANADA; Department of Ophthalmology, St. Michael's Hospital, Unity Health Toronto, CANADA; Kensington Vision and Research Centre, University of Toronto, CANADA. Electronic address:

Purpose: To compare visual acuity and photoreceptor integrity following vitrectomy (PPV) with drainage from the peripheral retinal break(s) (PRB) vs. posterior retinotomy (PR) vs. perfluorocarbon liquid (PFCL) for macula-off rhegmatogenous retinal detachment (RRD). Read More

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Corneal Sensitivity and Patient-Reported Dry Eye Symptoms in a Prospective Randomized Contralateral-Eye Trial Comparing LASIK and SMILE.

Am J Ophthalmol 2022 May 17. Epub 2022 May 17.

Byers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California. Electronic address:

Purpose: To prospectively compare corneal sensation and patient-reported symptoms of dry eye in individuals undergoing laser-assisted in situ keratomileusis (LASIK) and small incision lenticule extraction (SMILE).

Design: Prospective randomized contralateral-eye clinical trial.

Methods: 80 eyes of 40 patients with myopia at Byers Eye Institute at Stanford University were randomized to receive wavefront-guided femtosecond LASIK in one eye and SMILE in the fellow eye. Read More

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Cyclin D1 expression and molecular genetic findings in periocular histiocytoses and neoplasms of macrophage-dendritic cell lineage.

Am J Ophthalmol 2022 May 17. Epub 2022 May 17.

Department of Pathology, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA; Department of Ophthalmology, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: Frequent activating mutations in the mitogen-activated protein kinase (MAPK) pathway genes have been identified in histiocytoses. MAPK signaling consistently upregulates Cyclin D1. The goal of this study was to determine whether Cyclin D1 expression by immunohistochemistry is a useful diagnostic marker for periocular histiocytoses and to further characterize their genetic basis. Read More

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Adverse effects and Safety in Glaucoma Patients - Agreement on Clinical Trial Outcomes for Reports on Eye Drops (ASGARD) - A Delphi Consensus Statement.

Am J Ophthalmol 2022 May 17. Epub 2022 May 17.

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark; Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark. Electronic address:

Purpose: The purpose of this study is to establish consensus among experts on outcomes and methods to be used in clinical trials to assess adverse effects of anti-glaucomatous eye drops.

Design: Modified Delphi method.

Methods: Clinical experts from Europe, North America, South America, the Middle East, and Asia were invited to participate in two sequential web-based surveys administered from June 27 to August 29, 2021. Read More

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Ocular injuries from drive-by paintball shootings.

Am J Ophthalmol 2022 May 17. Epub 2022 May 17.

Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois 60637. Electronic address:

Purpose: To characterize ocular injuries from drive-by paintball shootings with a focus on the severity of injuries sustained, clinical management, and visual outcomes.

Design: Retrospective, interventional case series.

Methods: Setting: University practice and emergency department. Read More

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Increasing LGBTQ+ Visibility and Representation in Ophthalmology: A Professional Imperative.

Am J Ophthalmol 2022 May 17. Epub 2022 May 17.

Bascom Palmer Eye Institute, University of Miami Health System, 900 NW 17th Street, Miami, FL 33136, USA.

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Risk factors associated with intraocular lens decentration after cataract surgery.

Am J Ophthalmol 2022 May 17. Epub 2022 May 17.

Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China (J.X., P.M.L., S.H.Z., Y.L., T.Y.Z.); Eye Institute, Eye and ENT Hospital, Fudan University, Shanghai, China (J.X., P.M.L., S.H.Z., Y.L., T.Y.Z.); Key Laboratory of Myopia, Ministry of Health, Shanghai, China (J.X., P.M.L., S.H.Z., Y.L., T.Y.Z.); Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China (J.X., P.M.L., S.H.Z., Y.L., T.Y.Z.). Electronic address:

Purpose: To identify risk factors associated with intraocular lens (IOL) decentration after uneventful phacoemulsification with IOL implantation.

Design: A prospective cohort study METHODS: All patients underwent a general ophthalmologic examination. One month postoperatively, the magnitude and orientation of IOL decentration relative to the visual axis center were assessed using an OPD-Scan III aberrometer, and the vertical and horizontal decentration values were determined. Read More

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The role of counseling in Ophthalmology: Counseling in Ophthalmology.

Am J Ophthalmol 2022 May 11. Epub 2022 May 11.

Department of Ophthalmology, University of Warmia and Mazury, Olsztyn, Poland; Institute for Research in Ophthalmology, Foundation for Ophthalmology Development, Poznan, Poland. Electronic address:

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Vitrectomy Improves Contrast Sensitivity in Multifocal Pseudophakia with Vision Degrading Myodesopsia: Vitrectomy Improves Contrast Sensitivity in Multifocal Pseudophakia.

Am J Ophthalmol 2022 May 10. Epub 2022 May 10.

VMR Institute for Vitreous Macula Retina, Huntington Beach CA; Doheny Eye Institute/UCLA; Department of Ophthalmology, Stein Eye Institute, Geffen School of Medicine, UCLA. Electronic address:

Purpose: Multifocal intraocular lenses (MFIOL) are associated with degradation in contrast sensitivity function (CSF), yet the contribution of vitreous is not known, nor is the benefit of vitrectomy.

Design: Prospective, non-randomized clinical study METHODS: 180 eyes of 180 patients (55 MFIOL, 60 monofocal intraocular lenses (MIOL), 65 phakic) with symptomatic vitreous opacities were enrolled. Vitreous structure was assessed with quantitative ultrasonography (QUS). Read More

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Factors Associated with Gonioscopy-Assisted Transluminal Trabeculotomy (GATT) Complications and Failure in Children.

Am J Ophthalmol 2022 May 9. Epub 2022 May 9.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address:

Purpose: To identify the factors associated with the complications and failure of gonioscopy-assisted transluminal trabeculotomy (GATT) in children.

Design: retrospective case series METHODS: Setting - institutional Patient - children (age < 18 years) who had undergone GATT Observation procedures - records reviewed, pre- and postoperative intraocular pressures (IOP), extent of angle treated, medications, complications and failure were recorded. Failure was defined as IOP > 21 mmHg or < 5 mmHg, absence of at least 20% IOP reduction, performance of additional IOP-lowering surgery, or loss of light perception vision. Read More

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Longitudinal microstructure changes of the retina and choroid in retinitis pigmentosa.

Am J Ophthalmol 2022 May 9. Epub 2022 May 9.

Department of Ophthalmology, Seoul National University College of Medicine; Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea (CKY, KHB and HGY) Chair, Retina Center, the Sky Eye Institute (HGY). Electronic address:

Purpose: To investigate longitudinal changes in the retinal and choroidal microstructure of the macula in patients with retinitis pigmentosa (RP).

Design: Retrospective, observational cohort study METHODS: : Sixty-nine patients with RP and same number of age- and sex- matched controls who underwent optical coherence tomography (OCT) over a 4-year follow-up period were included. The severity of RP was classified into three stages according to the integrity of the inner segment ellipsoid zone. Read More

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Rates of Choroidal Microvasculature Dropout and Retinal Nerve Fiber Layer Changes in Glaucoma: Choroidal Dropout and Retinal Nerve Fiber Layer changes.

Am J Ophthalmol 2022 May 9. Epub 2022 May 9.

Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California. Electronic address:

Purpose: To evaluate the association between rates of choroidal microvasculature dropout (MvD) change and rates of circumpapillary retinal nerve fiber layer (cpRNFL) loss in primary open-angle glaucoma (POAG) eyes.

Design: Cohort study from clinical trial data METHODS: A total of 91 eyes of 68 POAG patients with and without localized MvD at baseline with at least 4 visits and 2 years follow-up with optical coherence tomography angiography (OCT-A) and OCT scans were included. Area and angular circumference of MvD were evaluated on OCT-A en-face and B-scan choroidal vessel density images during the follow-up period. Read More

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Metagenomic Profiling of the Ocular Surface Microbiome in Patients after Allogeneic Hematopoietic Stem Cell Transplantation: Ocular surface microbial dysbiosis and oGVHD.

Am J Ophthalmol 2022 May 9. Epub 2022 May 9.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China. Electronic address:

Purpose: To investigate the characteristics of the ocular surface microbiome in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and the associations between the microbial dysbiosis and chronic ocular graft-versus-host disease (oGVHD).

Design: Prospective cohort study.

Methods: Ocular surface samples from 48 healthy subjects and 76 patients after allo-HSCT, including 50 patients with chronic oGVHD and 26 patients without oGVHD were collected. Read More

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Severe Congenital Corneal Opacities.

Am J Ophthalmol 2022 May 8. Epub 2022 May 8.

Ophthalmology Department, American University of Beirut, Beirut, Lebanon. Electronic address:

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Comparison of the Effects of Latanoprostene Bunod and Timolol on Retinal Blood Vessel Density: A Randomized Clinical Trial.

Am J Ophthalmol 2022 May 5. Epub 2022 May 5.

Hamilton Glaucoma Center, Shiley Eye Institute, and the Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States. Electronic address:

Purpose: To compare the differences in retinal vessel density (VD) between topical administration of latanoprostene bunod (LBN) ophthalmic solution 0.024% and timolol maleate 0.5% in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT) and normal subjects. Read More

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How can we quantify and compare harm in surgical trials?

Am J Ophthalmol 2022 May 5. Epub 2022 May 5.

Centre for Public Health, Queen's University Belfast, United Kingdom. Electronic address:

Purpose: To describe methods that can be used to quantify and compare harm caused by surgical interventions in ophthalmology trials.

Design: Perspective study METHODS: A published landmark glaucoma trial was used as an exemplar. A consensus-derived classification system of severity of complications was applied to published data of the Tube versus Trabeculectomy (TVT) glaucoma trial. Read More

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Clinical outcomes in patients after duet procedure for reversible trifocality using a supplementary trifocal IOL.

Am J Ophthalmol 2022 May 5. Epub 2022 May 5.

Department of Ophthalmology, University Clinic Heidelberg, Heidelberg, Germany. Electronic address:

Purpose: We report the clinical outcomes of patients who had primary lens implantation in the capsular bag and subsequently a supplementary trifocal lens implanted in the ciliary sulcus (duet procedure) to create reversible trifocality.

Design: Retrospective interventional case series.

Methods: Twenty-five patients were included in this single center clinical study, who had undergone either refractive lens exchange for presbyopia correction or cataract surgery. Read More

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Scleritis in Lyme Disease.

Am J Ophthalmol 2022 May 2. Epub 2022 May 2.

From the Wilmer Eye Institute, the Department of Ophthalmology, the Johns Hopkins University School of Medicine, Baltimore, MD, USA; the Center for Clinical Trials and Evidence Synthesis, the Department of Epidemiology, the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Purpose: To estimate the incidence of scleritis in Lyme disease and report clinical features.

Design: Incidence rate estimate and case series METHODS: Data were collected from an electronic medical record on patients with scleritis resenting to the Wilmer Eye Institute between January 1, 2012 and December 31, 2020. A diagnosis of Lyme disease was made using the Infectious Diseases Society of America, American Academy of Neurology, and the American College of Rheumatology 2020 joint criteria plus a response to antibiotic therapy. Read More

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Pigmented posterior lenticonus in unilateral development cataract.

Am J Ophthalmol 2022 May 2. Epub 2022 May 2.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, Guangdong, China; Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China.

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Clinical course and outcome in pediatric idiopathic chronic anterior uveitis.

Am J Ophthalmol 2022 May 2. Epub 2022 May 2.

Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands.

Purpose: To examine the clinical course and outcome in children with idiopathic chronic anterior uveitis (iCAU) and compare the results with age-matched children with juvenile idiopathic arthritis-associated uveitis (JIA-U).

Design: Retrospective cohort study.

Methods: Data regarding ocular complications, visual acuity, and systemic treatment were retrospectively collected for two patient groups that were matched regarding age and year of uveitis diagnosis. Read More

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Minimally invasive corneal neurotization provides sensory function, protects against recurrent ulceration, and improves visual acuity.

Am J Ophthalmol 2022 May 2. Epub 2022 May 2.

Department of Ophthalmology & Vision Sciences, The Hospital for Sick Children, Toronto, Canada; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Purpose: To measure sensory recovery after minimally invasive corneal neurotization and to identify and quantify the extent to which patient and technical factors influence sensory recovery, ulceration rate, and visual outcomes.

Design: Retrospective case series METHODS: : This study included 23 patients with neurotrophic keratopathy who underwent indirect corneal neurotization. The primary outcome measure was corneal sensitivity with Cochet-Bonnet Aesthesiometry (CBA) and the secondary outcome measure was epithelial breakdown. Read More

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Diagnostic accuracy of macular thickness map and texture en-face images for detecting glaucoma in eyes with axial high myopia.

Am J Ophthalmol 2022 May 2. Epub 2022 May 2.

Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, UC San Diego, La Jolla, CA, United States. Electronic address:

Purpose: To evaluate the diagnostic accuracy of a novel optical coherence tomography (OCT) texture-based en-face image analysis, called SALSA-Texture, that requires segmentation of only one retinal layer for glaucoma detection in eyes with axial high myopia, and to compare to standard macular ganglion cell-inner plexiform layer (GCIPL) thickness, macular retinal nerve fiber layer (mRNFL) thickness, and ganglion cell complex (GCC) thickness maps.

Design: Comparison of diagnostic approaches.

Methods: Cross-sectional data were collected from 92 primary open-angle glaucoma (POAG) eyes and 44 healthy eyes with axial high myopia (axial length > 26 mm). Read More

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