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Am J Obstet Gynecol 2022 May 14. Epub 2022 May 14.

Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, China; Department of Obstetrics and Gynaecology, Seventh Medical Center, Chinese PLA General Hospital, Beijing, China.

Background: There are limited data to guide the duration and dose of oxygen supplementation to pregnant women undergoing labor.

Objective: To assess the effect of maternal long-duration high-concentration oxygen administration during labor on umbilical cord venous partial pressure of oxygen.

Study Design: This randomized clinical trial was conducted between January 2021 and October 2021 in the obstetrics wards of three tertiary teaching hospitals in Beijing, China. Read More

Am J Obstet Gynecol 2022 May 14. Epub 2022 May 14.

Providence, RI; Division of Urogynecology and Reconstructive Pelvic Surgery, Warren Alpert Medical School of Brown University/Women & Infants Hospital of Rhode Island; 101 Plain Street, 5th Floor, Providence, RI 02903.

Background: The efficacy of intradetrusor onabotulinumtoxinA injections for management of idiopathic overactive bladder has been well established. The injections are typically performed in the office setting utilizing local analgesia, most commonly a 20-30 minute intravesical instillation of lidocaine. There is limited data evaluating alternative bladder analgesics. Read More

Am J Obstet Gynecol 2022 May 14. Epub 2022 May 14.

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI.

Background: Same-day discharge (SDD) following minimally invasive hysterectomy (MIH) has been shown to be safe and feasible in select populations, but many non-clinical factors influencing SDD remain unexplored.

Objective: To develop prediction models for SDD following MIH using both clinical and non-clinical attributes and to compare model concordance of individual attribute groups.

Study Design: We performed a retrospective study of patients who underwent elective MIH for benign gynecologic indications at 69 hospitals in a statewide quality improvement collaborative between 2012 and 2019. Read More

Am J Obstet Gynecol 2022 May 14. Epub 2022 May 14.

Department of Gynecology and Obstetrics, Diakovere Hospital, Hannover, Germany.

Background: Gestational diabetes mellitus is one of the most frequent pregnancy complications with a global prevalence of 13.4% in 2021. Pregnant women with COVID-19 and gestational diabetes mellitus are 3. Read More

Am J Obstet Gynecol 2022 May 13. Epub 2022 May 13.

Department of Obstetrics and Gynecology, University Hospital Brugmann, Université Libre de Bruxelles, Brussels, Belgium. Electronic address:

Am J Obstet Gynecol 2022 May 13. Epub 2022 May 13.

Department of Obstetrics and Gynecology, Division of Minimally Invasive Gynecology, The Ottawa Hospital, Ottawa, Ontario, Canada.

Am J Obstet Gynecol 2022 May 12. Epub 2022 May 12.

Medicines360, San Francisco, CA, USA.

Background: Extending hormonal intrauterine system (IUS) duration will allow users to have less need for procedures to provide long-term contraception.

Objective: Evaluate efficacy and safety of levonorgestrel 52 mg IUS during years 7 and 8 of use.

Study Design: A total of 1751 nulliparous and multiparous 16-45 year old participants enrolled in a phase 3 multicenter trial to evaluate efficacy and safety of the Liletta levonorgestrel 52 mg IUS for up to 10 years. Read More

Am J Obstet Gynecol 2022 May 12. Epub 2022 May 12.

Columbia University Irving Medical Center, Department of Obstetrics and Gynecology, New York, NY.

Background: Inpatient insertion of long-acting reversible contraception (LARC) and immediate postpartum tubal ligation allow women to initiate highly effective contraception prior to hospital discharge.

Objective: We measured rates of intrauterine device (IUD) and contraceptive implant initiation and tubal ligations performed during delivery hospitalizations from 2016-2018 from a representative sample of United States hospital discharges.

Methods: We used the 2016-2018 National Inpatient Sample (NIS) database, a 20% sample of all community hospital discharges in the United States, to identify delivery hospitalizations with concomitant IUD insertion, contraceptive implant insertion, or tubal ligation. Read More

Am J Obstet Gynecol 2022 May 11. Epub 2022 May 11.

Division of Female Pelvic Medicine and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL.

Background: Symptomatic pelvic organ prolapse is common and affects 25% - 35% of women worldwide. As this growing patient need is being met by surgeons from diverse training backgrounds, it is important to both characterize differences in surgeon practice patterns and examine postoperative outcomes to ensure optimal patient care.

Objective: To determine the association between surgeon specialty and postoperative outcomes following surgery for pelvic organ prolapse. Read More

Am J Obstet Gynecol 2022 May 11. Epub 2022 May 11.

Harvard T.H. Chan School of Public Health, Building 1, 665 Huntington Avenue, Boston, MA 02115, USA.

Background: Previous studies have suggested emergent events may affect pregnancy planning decisions. However, few have investigated the impact of factors related to the COVID-19 pandemic on pregnancy planning, measured by attempting conception, and how attempting conception status may differ by individual level factors such as social status or education level.

Objective: To examine the effects of factors related to the COVID-19 pandemic, through March 2021, on attempting conception status. Read More

Am J Obstet Gynecol 2022 May 11. Epub 2022 May 11.

Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Birth Defect Control and Prevention Research Center of Zhejiang Province, Hangzhou, Zhejiang, China; International Science and Technology Cooperation Base of Reproductive Health of Zhejiang Province, Hangzhou, Zhejiang, China.

Background: Embryos with higher morphological quality may have a greater potential to achieve clinical pregnancy leading to live birth regardless of the type of cleavage-stage embryos or blastocysts. Few studies have investigated the impacts of embryo grading on the long-term health of offspring.

Objective: This pilot study aimed to examine the associations between embryo morphological quality and the physical, metabolic and cognitive development of singletons conceived by in vitro fertilization/intracytoplasmic sperm injection at their pre-school age. Read More

Am J Obstet Gynecol 2022 May 11. Epub 2022 May 11.

Fetal Medicine Unit, St George's Hospital, St George's University of London, UK; Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, UK; Liverpool Women's Hospital, Liverpool, UK. Electronic address:

Despite recent endorsement from official and professional bodies, unequivocally recommending COVID-19 vaccination, hesitancy among pregnant persons remains high. The accumulated evidence clearly demonstrates that pregnant persons are a special risk group for COVID-19, with increased risk of intensive care unit admission, extracorporeal membranous oxygenation requirement, preterm birth and perinatal death. These risks are further increased with some variants of concern, and vaccination of pregnant persons reduces the COVID related increase in maternal or fetal morbidity. Read More

Am J Obstet Gynecol 2022 May 10. Epub 2022 May 10.

Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital, Niigata, Japan.

Am J Obstet Gynecol 2022 May 10. Epub 2022 May 10.

Division of Gynecologic Oncology, California Pacific Medical Center, Palo Alto Medical Foundation, Sutter Research Institute, San Francisco, CA, USA. Electronic address:

Am J Obstet Gynecol 2022 May 10. Epub 2022 May 10.

Department of Obstetrics and Gynecology, Walter, Reed National Military Medical Center, Bethesda, Maryland; Urogynecology Department, Sibley Memorial Hospital (Johns Hopkins Medicine), Washington, District of Columbia.

Am J Obstet Gynecol 2022 May 10. Epub 2022 May 10.

Division of Pediatrics and Neonatal Critical Care, "Antoine Béclère" Medical Centre, Paris Saclay University Hospitals, APHP, Clamart, France; Physiopathology and Therapeutic Innovation Unit-INSERM U999, Paris Saclay University, Le Plessis Robinson, France. Electronic address:

Am J Obstet Gynecol 2022 May 9. Epub 2022 May 9.

Consultant Obstetrician and Urogynaecologist, Croydon University Hospital, Honorary Reader, St George's University of London. Electronic address:

Objectives: To systematically determine the incidence of wound infection and wound dehiscence following primary obstetric anal sphincter injury (OASI) repair.

Data Sources: Medline, EMBASE, CINAHL, EMCARE, Cochrane and Trip Pro databases were searched from database inception to February 2021.

Study Eligibility Criteria: We included observational clinical studies reporting the incidence of wound infection and dehiscence following primary OASI repair. Read More

Am J Obstet Gynecol 2022 May 9. Epub 2022 May 9.

Department of Urogynecology, TriHealth, Cincinnati, OH.

Background: Patients undergoing vaginal hysterectomy with native tissue pelvic reconstruction typically have low pain levels overall in the postoperative period. Notwithstanding, pain control immediately following surgery may be more challenging and a barrier to same-day discharge. Intrarectal diazepam has been utilized for acute and chronic pelvic pain and has a pharmacokinetic profile ideal for intermittent use. Read More

Am J Obstet Gynecol 2022 May 9. Epub 2022 May 9.

Department of Gynecologic Surgery & Obstetrics, Uniformed Services University of the Health Sciences, San Antonio, Texas.

Am J Obstet Gynecol 2022 May 9. Epub 2022 May 9.

Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA.

Am J Obstet Gynecol 2022 May 9. Epub 2022 May 9.

Department of Anesthesiology, University of Utah Hospital, 50 N. Medical Drive, Salt Lake City, UT 84132.

Background: Postoperative opioid prescribing has historically lacked information critical to balancing the pain control needs of the individual patient with our professional responsibility to judiciously prescribe these high-risk medications.

Objective: To evaluate pain control, satisfaction with pain control, and opioid utilization among patients undergoing isolated mid-urethral sling (MUS) randomized to one of two different opioid prescribing regimens.

Study Design: Patients who underwent isolated MUS placement from June 1, 2020 until November 22, 2021 were offered enrollment into this prospective, randomized, open-label, non-inferiority clinical trial. Read More

Am J Obstet Gynecol 2022 May 7. Epub 2022 May 7.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario Canada; Department of Obstetrics, Gynecology & Newborn Care, The Ottawa Hospital, Ottawa, Canada.

Am J Obstet Gynecol 2022 May 7. Epub 2022 May 7.

Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Jewish General Hospital, Montreal, Quebec, Canada. Electronic address:

Am J Obstet Gynecol 2022 May 7. Epub 2022 May 7.

Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.

Am J Obstet Gynecol 2022 May 6. Epub 2022 May 6.

- Department of Cardiovascular Diseases, Saint Luke's Mid America Heart Institute, Kansas City, MO, USA; - Department of Internal Medicine, University of Missouri-Kansas City, Kansas City, MO, USA.

Am J Obstet Gynecol 2022 May 2. Epub 2022 May 2.

Obstetric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna.

Am J Obstet Gynecol 2022 Apr 30. Epub 2022 Apr 30.

Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center.

Objective: Migraine affects 28% of women in their pregnancy-capable years, and is associated with systemic inflammation, endothelial dysfunction, and increased risk of pregnancy-associated thromboembolic events. Migraine history has been associated with adverse pregnancy outcomes (APO) of placental origin, including hypertensive disorders of pregnancy (HDP) and preterm birth (PTB). We tested the hypothesis that self-reported migraine in nulliparous individuals is associated with higher odds of APO. Read More

Am J Obstet Gynecol 2022 May;226(5):605-606

Division of Women's Community and Population Health, Department of Obstetrics & Gynecology, Duke University School of Medicine, Durham, NC. Electronic address:

Am J Obstet Gynecol 2022 May;226(5):603-604

Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, and Detroit, MI.

Am J Obstet Gynecol 2022 Apr 29. Epub 2022 Apr 29.

Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel; Department of Obstetrics & Gynecology, Galilee Medical Center, Nahariya, Israel.

Background: Preeclampsia is a multisystem disorder and the leading cause of severe morbidity and death in pregnancy. Liver involvement in preeclampsia ranges from elevated liver enzyme levels to hepatic infarction or rupture. Endothelial dysfunction leads to changes in blood flow and congestion and may be involved in the pathophysiology of preeclampsia. Read More