371,544 results match your criteria American Journal Of Medical Genetics Part C-seminars In Medical Genetics[Journal]


Incidence and risk factors for acute delirium in older patients with a hip fracture: A retrospective cohort study.

Nurs Health Sci 2020 Jul 5. Epub 2020 Jul 5.

School of Nursing and Midwifery, Centre for Quality and Patients Safety Research Faculty of Health, Deakin University, Geelong, Victoria, Australia.

This retrospective cohort study aimed to determine the incidence, and preoperative, intraoperative and postoperative risk factors for postoperative delirium in older patients undergoing surgical fixation of a hip fracture. Electronic medical records were examined of 260 patients who underwent a surgical fixation of a hip fracture between June 2017 and October 2018 at a university-affiliated tertiary care hospital in Victoria, Australia. Demographic, clinical and perioperative data were examined for potential risk factors for postoperative delirium. Read More

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http://dx.doi.org/10.1111/nhs.12753DOI Listing

Developing a standard set of patient-centred outcomes for adult oral health - an international, cross-disciplinary consensus.

Int Dent J 2020 Jul 5. Epub 2020 Jul 5.

ICHOM Adult Oral Health Working Group, Boston, MA, USA.

Objective: To develop a minimum Adult Oral Health Standard Set (AOHSS) for use in clinical practice, research, advocacy and population health.

Materials And Methods: An international oral health working group (OHWG) was established, of patient advocates, researchers, clinicians and public health experts to develop an AOHSS. PubMed was searched for oral health clinical and patient-reported measures and case-mix variables related to caries and periodontal disease. Read More

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http://dx.doi.org/10.1111/idj.12604DOI Listing

Outcomes of Bariatric Surgery in African Americans: an Analysis of the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) Data Registry.

Obes Surg 2020 Jul 4. Epub 2020 Jul 4.

Atrium Health Weight Management, Section of Bariatric & Metabolic Surgery, Department of Surgery, Carolinas Medical Center, Atrium Health, Charlotte, NC, 28204, USA.

Background: The incidence of obesity is disproportionally high in African Americans (AA) in the United States. This study compared outcomes for AA patients undergoing Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) with non-AA patients.

Methods: The MBSAQIP database was reviewed for RYGB and SG patients (2015-2017). Read More

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http://dx.doi.org/10.1007/s11695-020-04820-wDOI Listing

Scientometric analysis: identification of research trends for ozone as an air pollutant for 2011-2019.

Environ Sci Pollut Res Int 2020 Jul 4. Epub 2020 Jul 4.

School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India.

Ground level ozone is a major air pollutant with known toxic effects on humans. The research field is well established with many scientists from developed and developing countries contributing original research articles. Strict regulations for ozone air pollution are being implemented worldwide based on supporting scientific literature. Read More

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http://dx.doi.org/10.1007/s11356-020-09941-4DOI Listing

Socioeconomic Correlates of Obesity in African-American and Caribbean-Black Men and Women.

J Racial Ethn Health Disparities 2020 Jul 4. Epub 2020 Jul 4.

Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Harvard University, 677 Huntington Ave, Room 709, Boston, MA, 02115, USA.

The high prevalence of obesity among Black Americans warrants additional investigation into its relationship with socioeconomic position (SEP), sex, and ethnicity. This cross-sectional study utilizes 2001-2003 data from the National Survey of American Life, a nationally representative sample of 3570 African-Americans and 1621 Caribbean-Blacks aged 18 years and older. Multivariate logistic regression models stratified by ethnicity and sex describe the independent associations between obesity and multilevel socioeconomic factors after adjustment for age, other SEP measures at the individual, family and neighborhood levels, and health behaviors such as physical activity, alcohol intake, and smoking. Read More

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http://dx.doi.org/10.1007/s40615-020-00798-4DOI Listing

Effect of delayed cord clamping on stem cell transfusion and hematological parameters in preterm infants with placental insufficiency: a pilot randomized trial.

Eur J Pediatr 2020 Jul 4. Epub 2020 Jul 4.

Neonatal Intensive Care Unit, Department of Pediatrics, Mansoura University Children's Hospital, Gomhoria Street, Mansoura, 35516, Egypt.

The feasibility of delayed cord clamping (DCC) in preterm infants with placental insufficiency (PI) is questionable. We aimed to study the effect of DCC on stem cell transfusion, hematological parameters, and clinical outcomes in preterm infants born to mothers with PI. Preterm infants, < 34 weeks' gestation, born to mothers with PI were randomized based on the timing of umbilical cord clamping into delayed clamping for 60 s (DCC group) or immediate cord clamping (ICC group) groups at time of birth. Read More

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http://dx.doi.org/10.1007/s00431-020-03730-4DOI Listing

Whole exome sequencing identifies novel compound heterozygous pathogenic variants in the MYO15A gene leading to autosomal recessive non-syndromic hearing loss.

Mol Biol Rep 2020 Jul 4. Epub 2020 Jul 4.

Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Autosomal recessive non-syndromic hearing loss (ARNSHL) is a highly heterogeneous disease, for which more than 70 genes have been identified. MYO15A mutations have been reported to cause congenital severe-to-profound HL. In this study, we applied the whole exome sequencing (WES) to find the cause of HL in an Iranian family. Read More

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http://dx.doi.org/10.1007/s11033-020-05618-wDOI Listing

The MelFo Study UK: Effects of a Reduced-Frequency, Stage-Adjusted Follow-Up Schedule for Cutaneous Melanoma 1B to 2C Patients After 3-Years.

Ann Surg Oncol 2020 Jul 4. Epub 2020 Jul 4.

Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Evidence-based guidelines for follow-up treatment of American Joint Committee on Cancer (AJCC) stages 1B to 2C melanoma patients are lacking. The MELanoma FOllow-up study is an international phase 3 randomized trial, and the 3-year interim data were recently reported from the Netherlands. The study was undertaken concurrently with a British cohort for comparison and validation of the Dutch study. Read More

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http://dx.doi.org/10.1245/s10434-020-08758-2DOI Listing

Healthcare Utilization of Menthol and Non-menthol Cigarette Smokers.

Nicotine Tob Res 2020 Jul 5. Epub 2020 Jul 5.

Institute for Health & Aging, School of Nursing, University of California, San Francisco, San Francisco, CA, USA.

Objective: To study the association between healthcare utilization and menthol cigarette use and whether the association differed between African American (AA) and non-African American (non-AA) smokers.

Methods: We analyzed the three most recent 2005, 2010, and 2015 National Health Interview Survey Cancer Control Supplements. After incorporating propensity score weights adjusting for observed differences between menthol and non-menthol users, we estimated Zero-Inflated Poisson models on hospital nights, emergency department (ED) visits, doctor visits, and home visits as a function of menthol use status and other covariates separately for current cigarette smokers and recent quitters (former smokers quitting cigarette smoking≤4 years). Read More

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http://dx.doi.org/10.1093/ntr/ntaa122DOI Listing

Use of ultrasound at a pilot scale to accelerate the ageing of sherry vinegar.

Ultrason Sonochem 2020 Jul 1;69:105244. Epub 2020 Jul 1.

Analytical Chemistry Department, Faculty of Sciences-IVAGRO, University of Cadiz, Agrifood Campus of International Excellence, Post Office Box 40, Pol. Río San Pedro, Puerto Real 11510, Cadiz, Spain.

In the present work, the accelerated ageing process of sherry vinegar has been studied at pilot scale by means of the joint application of ultrasound, micro-oxygenation and wood chips (American oak, French oak and Spanish oak). The CIELab parameters have been studied as well as the polyphenolic and volatile content of the aged vinegar samples. Vinegars aged with American oak presented different chromatic characteristics to those aged with French and Spanish oak and a lower polyphenolic and volatile content than the latter ones. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2020.105244DOI Listing

'That is why we raise children': African American fathers' race-related concerns for their adolescents and parenting strategies.

J Adolesc 2020 Jul 2;82:67-81. Epub 2020 Jul 2.

University of North Carolina at Chapel Hill, United States.

Introduction: The current study highlights the voices and perspectives of African American fathers, with specific emphasis on their race-related concerns for their adolescents as well as how these concerns guide their parenting strategies.

Method: Twenty-four African American fathers participated in 1.5-3 h long focus group interviews. Read More

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http://dx.doi.org/10.1016/j.adolescence.2020.06.001DOI Listing

COVID-19 and frequent use of hand sanitizers; human health and environmental hazards by exposure pathways.

Sci Total Environ 2020 Jun 27;742:140561. Epub 2020 Jun 27.

Innovative Green Product Synthesis and Renewable Environment Development Research Group, Faculty of Environment and Labour Safety, Ton Duc Thang University, Ho Chi Minh City, Viet Nam. Electronic address:

Till date no medication or vaccine is available to cope with the COVID-19 infection and infection rate is increasing drastically across the globe. Only preventive measures and healthy life style with efficient immune system have been suggested by WHO to fight and stay safe from COVID-19. WHO recommended alcohol based hand sanitizers for frequent hand hygiene, which are mainly made up from ethanol, isopropyl alcohols, hydrogen peroxides in different combinations. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140561DOI Listing

Neuroimaging findings in headache with normal neurologic examination: Systematic review and meta-analysis.

J Neurol Sci 2020 Jun 26;416:116997. Epub 2020 Jun 26.

Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.

Objective: To determine if pooled estimates of the prevalence of unexpected findings in patients with headache and normal neurologic examination support current expert opinion-based neuroimaging guidelines.

Methods: We searched PubMed and EMBASE for studies reporting neuroimaging findings in patients with headache and normal neurologic examination up to September 30, 2017. The overall and disease-specific prevalence of unexpected findings were pooled through random-effects meta-analysis. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116997DOI Listing

Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with COVID-19.

Int J Infect Dis 2020 Jul 2. Epub 2020 Jul 2.

Infectious Diseases, Henry Ford Hospital, Detroit, MI, United States; Wayne State University School of Medicine, Detroit, MI, United States. Electronic address:

Significance: The United States is in an acceleration phase of the COVID-19 pandemic. Currently there is no known effective therapy or vaccine for treatment of SARS-CoV-2, highlighting urgency around identifying effective therapies.

Objective: The purpose of this study was to evaluate the role of hydroxychloroquine therapy alone and in combination with azithromycin in hospitalized patients positive for COVID-19. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.099DOI Listing

Undetectable circulating tumor DNA levels correlate with low risk of recurrence/metastasis in postoperative pathologic stage I lung adenocarcinoma patients.

Lung Cancer 2020 Jun 20;146:327-334. Epub 2020 Jun 20.

Department of Thoracic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:

Objectives: The application of circulating tumor DNA (ctDNA) monitoring after resection in pathologic(p) stage I lung adenocarcinoma (LUAD) patients remains controversial and it is of great clinical interest to decipher the difference of genetic features between ground-glass opacity (GGO) and solid nodules (non-GGO) subgroups. We aim to assess the utility of ctDNA in tracking early recurrence or metastasis following surgery and reveal the genetic differences between GGO and non-GGO.

Materials And Methods: Tumor tissues and matched postoperative plasma samples were collected from a total of 82 (p)stage I LUAD patients. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.06.009DOI Listing

Natural Course of Nicotine Dependence Among Adolescent Waterpipe and Cigarette Smokers.

J Adolesc Health 2020 Jul 1. Epub 2020 Jul 1.

Department of Epidemiology, Robert Stempel College of Public Health, Florida International University, Miami, Florida; Syrian Center for Tobacco Studies, Aleppo, Syria. Electronic address:

Purpose: Waterpipe (WP) smoking patterns and setting can result in a unique trajectory of nicotine dependence (ND) compared with cigarette smoking. This longitudinal study compared the development of ND symptoms among adolescent WP and cigarette smokers.

Methods: A cohort of 647 eighth and ninth graders in Lebanon were followed over 5 years. Read More

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http://dx.doi.org/10.1016/j.jadohealth.2020.04.030DOI Listing

Young Women's Perceptions of Heart Disease Risk.

J Adolesc Health 2020 Jul 1. Epub 2020 Jul 1.

Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.

Purpose: Heart disease is the number one cause of death in women. Little is known about how adolescent and young adult women perceive their risk of heart disease.

Methods: We conducted eight online, semistructured focus groups with 35 young women aged 15-24 years recruited from two primary care practices in Boston, MA. Read More

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http://dx.doi.org/10.1016/j.jadohealth.2020.05.010DOI Listing

Assessing concordance of financial conflicts of interest disclosures with payments' databases: a systematic survey of the health literature.

J Clin Epidemiol 2020 Jul 2. Epub 2020 Jul 2.

Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon; Clinical Research Institute, American University of Beirut Medical Center, Beirut, Lebanon; Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. Electronic address:

Objective: To review the literature for studies that assessed the concordance of financial conflicts of interest disclosures with payments' databases and evaluate their methods.

Study Design: & setting: We conducted a systematic survey of the health literature to identify eligible studies. We searched both Medline and EMBASE up to February 2017. Read More

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http://dx.doi.org/10.1016/j.jclinepi.2020.06.040DOI Listing

The spectrum of COVID-19-associated dermatologic manifestations: an international registry of 716 patients from 31 countries.

J Am Acad Dermatol 2020 Jul 2. Epub 2020 Jul 2.

Department of Dermatology, University of California San Francisco, San Francisco, CA.

Background: Coronavirus disease 2019 (COVID-19) has associated cutaneous manifestations.

Objective: To characterize the diversity of cutaneous manifestations of COVID-19, and facilitate understanding of underlying pathophysiology.

Methods: Case series from an international registry from the American Academy of Dermatology and International League of Dermatological Societies. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.06.1016DOI Listing

Should abbreviated breast MRI be compliant with American College of Radiology requirements for MRI accreditation?

Magn Reson Imaging 2020 Jul 2. Epub 2020 Jul 2.

Department of Diagnostic Radiology, UT Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75390-8585, United States of America. Electronic address:

Objective: To evaluate non-inferiority and diagnostic performance of an American College of Radiology compliant abbreviated MRI protocol (AB-MRI) compared with standard-of-care breast MRI (SOC-BMRI) in patients with increased breast cancer risk.

Material And Methods: Women with increased lifetime breast cancer risk by American Cancer Society guidelines underwent breast MRI at a single institution between October 2015 and February 2018. AB-MRI was acquired at 3. Read More

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http://dx.doi.org/10.1016/j.mri.2020.06.017DOI Listing

Development of Learning Curves for Bronchoscopy Results of a Multicentre Study of Pulmonary Trainees.

Chest 2020 Jul 2. Epub 2020 Jul 2.

Department of Innovation in Medical Education, University of Ottawa, Ottawa, Canada; Department of Anesthesiology and Pain Medicine, University of Ottawa, Ottawa, Canada.

Background: There are currently no reference standards for the development of competency in bronchoscopy.

Research Question: The aims of this study were to 1) develop learning curves for bronchoscopy skill development and 2) estimate the number of bronchoscopies required to achieve competence.

Study Design And Methods: Trainees from seven North American academic centers were enrolled at the beginning of their Pulmonology training. Read More

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http://dx.doi.org/10.1016/j.chest.2020.06.046DOI Listing

Restructuring Radiology Education to Improve Imaging Specificity.

Acad Radiol 2020 Jul 1. Epub 2020 Jul 1.

Thomas Jefferson University Hospital, Radiology, 132 South 10th Street, Suite 1087, Main Building, Philadelphia, PA 19107.

Quotes such as "an ounce of prevention is worth a pound of cure" (Benjamin Franklin) and "a good doctor cures the disease, but a great doctor cures the cause" (Amit Kalantri), are poignant reminders of the overwhelming power of preventive medicine on population health. Why, then, would it not be that the health of our medical system would not benefit from the same sort of ideas? Medical imaging is considered over utilized and numerous strategies have attempted to address this including "Choosing Wisely," American College of Radiology appropriateness criteria, clinical decision support instruments and others. Most of these have been partially successful, but none have yet to turn the tide of over imaging. Read More

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http://dx.doi.org/10.1016/j.acra.2020.06.011DOI Listing

Time Trends and Risk Factors for 30-Day Adverse Events in Black Patients Undergoing Primary Total Knee Arthroplasty.

J Arthroplasty 2020 Jun 12. Epub 2020 Jun 12.

Department of Orthopaedic Surgery, Baylor College of Medicine, Houston, TX.

Background: Increased adverse events (AEs) have been reported among black patients undergoing joint arthroplasty, but little is known about their persistence and risk factors. The purpose of this study is (1) to examine recent annual trends in 30-day outcomes after total knee arthroplasty (TKA) and (2) to develop a preoperative risk stratification model in this racial minority.

Methods: The American College of Surgeons National Surgical Quality Improvement Program was queried for all black/African American patients who underwent primary TKA between 2011 and 2017. Read More

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http://dx.doi.org/10.1016/j.arth.2020.06.013DOI Listing

Prediction of Pleural Adhesions by Lung Ultrasonography: An Observational Study.

J Cardiothorac Vasc Anesth 2020 Jun 13. Epub 2020 Jun 13.

Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Objective: Pleural adhesion makes video-assisted thoracoscopic surgery (VATS) an arduous procedure and can increase postoperative pain from accompanying adhesiolysis. For the present study, the feasibility of lung ultrasonography for the prediction of pleural adhesions and postoperative pain in VATS was investigated.

Design: Blinded, prospective, observational study. Read More

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http://dx.doi.org/10.1053/j.jvca.2020.06.030DOI Listing

Hispanic/Latino heritage group disparities in sleep and the sleep-cardiovascular health relationship by housing tenure status in the United States.

Sleep Health 2020 Jul 1. Epub 2020 Jul 1.

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA; Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Electronic address:

Objectives: The objective of this study was to investigate whether the sleep-cardiovascular health (CVH) association varies by Hispanic/Latino heritage group and housing tenure status (i.e., homeownership, unassisted housing, government-assisted housing), which is an important social determinant of health. Read More

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http://dx.doi.org/10.1016/j.sleh.2020.01.005DOI Listing

Youth and adult public views of dairy calf housing options.

J Dairy Sci 2020 Jul 1. Epub 2020 Jul 1.

Department of Animal Science, University of Minnesota, St. Paul 55108. Electronic address:

The objective of this study was to explore views on dairy calf housing options among American youth and adults. Youth views were of interest because they are future consumers, yet their influence on livestock production practices is often overlooked. Participants 5 to 17 yr of age (n = 463) and 18 yr or older (n = 1,310) completed an in-person survey at the Minnesota State Fair (St. Read More

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http://dx.doi.org/10.3168/jds.2019-17727DOI Listing

Endocrine surgery is at the forefront of gender diversity.

Am J Surg 2020 Jun 23. Epub 2020 Jun 23.

University of Alabama at Birmingham, Department of Surgery, Birmingham, AL, USA. Electronic address:

Background: The purpose of this study is to assess gender diversity across surgical subspecialties, with a focus on endocrine surgery.

Methods: We collected publicly-reported data from Association of American Medical Colleges (AAMC) and American Association of Endocrine Surgeons (AAES) during the 2017 data period. Student's t-test and Analysis of Variance (ANOVA) were used to compare percentages of female surgeons. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.06.008DOI Listing

Principles of ethics and critical communication during the COVID-19 pandemic.

Gynecol Oncol 2020 Jun 25. Epub 2020 Jun 25.

Division of Gynecologic Oncology, Texas Oncology, Baylor University Medical Center, Dallas, TX, United States of America.

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http://dx.doi.org/10.1016/j.ygyno.2020.06.494DOI Listing

Do rural patients with operable breast cancer fare worse than urban patients in Louisiana? Results of the Louisiana cancer consortium.

Surgery 2020 Jul 1. Epub 2020 Jul 1.

Louisiana Tumor Registry & Epidemiology and School of Public Health at LSU Health Sciences Center-New Orleans, LA.

Background: It is unknown whether rural patients with operable breast cancer do worse than urban patients in Louisiana. We performed an analysis of breast cancer based on rural versus urban residencies and evaluate factors associated with worse survival.

Methods: Data on women diagnosed with stages I to III breast cancer from 2004 to 2016 were obtained from the Louisiana Tumor Registry. Read More

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http://dx.doi.org/10.1016/j.surg.2020.04.053DOI Listing

Prevalence, Awareness, Treatment, and Poor Control of Hypertension Among Young American Adults: Race-Stratified Analysis of the National Health and Nutrition Examination Survey.

Mayo Clin Proc 2020 Jul;95(7):1390-1403

Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL; Section of Cardiology, Birmingham Veterans Affairs Medical Center, Birmingham, AL. Electronic address:

Objective: To evaluate the race-stratified trends for prevalence, awareness, treatment, and control of hypertension in young American adults aged 18 to 44 years.

Patients And Methods: The National Health and Nutrition Examination Survey data from 2005-2016 for adults aged 18 to 44 years was used to calculate age-adjusted (using 2005, 2010, and 2015 US Census population proportions) weighted trends in prevalence, awareness, treatment, and control of hypertension among non-Hispanic white, non-Hispanic black, and Mexican-American participants as per the 2017 American College of Cardiology/American Heart Association guidelines. Trends were estimated by logistic regression models including demographic, socioeconomic, health care access, and Bonferroni correction for multiple comparisons as covariates. Read More

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http://dx.doi.org/10.1016/j.mayocp.2020.01.041DOI Listing

Cardiovascular Risk Factors and Atherosclerotic Cardiovascular Events Among Incident Cases of Systemic Sclerosis: Results From a Population-Based Cohort (1980-2016).

Mayo Clin Proc 2020 Jul;95(7):1369-1378

Division of Rheumatology, Mayo Clinic, Rochester, MN. Electronic address:

Objective: To characterize cardiovascular (CV) risk factors and outcomes among incident cases of systemic sclerosis (SSc) in a population-based cohort.

Methods: Medical records of patients with SSc diagnosed in Olmsted County, Minnesota, between January 1, 1980, and December 31, 2016, were reviewed to identify 78 incident SSc cases. The comparators were 156 sex- and age-matched individuals from the same population. Read More

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http://dx.doi.org/10.1016/j.mayocp.2019.12.015DOI Listing

EFFECT OF LOWER BLOOD PRESSURE GOALS ON LEFT VENTRICULAR STRUCTURE AND FUNCTION IN PATIENTS WITH SUBCLINICAL HYPERTENSIVE HEART DISEASE.

Am J Hypertens 2020 Jul 5. Epub 2020 Jul 5.

Department of Internal Medicine, Southern Illinois University, Springfield, Il.

Background: Subclinical hypertensive heart disease (SHHD) is a precursor to heart failure. Blood pressure (BP) reduction is an important component of secondary disease prevention in patients with SHHD. Treating patients with SHHD utilizing a more intensive BP target (120/80 mm Hg), may lead to improved cardiac function but there has been limited study of this, particularly in African Americans (AAs). Read More

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http://dx.doi.org/10.1093/ajh/hpaa108DOI Listing

Perceptions and experiences of multiple sclerosis patients regarding out-of-pocket costs of care discussions.

Mult Scler Relat Disord 2020 Jun 28;45:102344. Epub 2020 Jun 28.

Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States. Electronic address:

Background And Purpose: Multiple sclerosis (MS) is a costly disease and out-of-pocket (OOP) cost information is difficult to obtain. We seek to characterize the perceptions and experiences of MS patients regarding out-of-pocket (OOP) costs of care discussions and evaluate factors associated with them.

Materials And Methods: MS patients visiting an outpatient neurology clinic 7/2018-2/2019 were approached to complete a survey regarding costs of care discussions. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102344DOI Listing

Lactobacillus reuteri associated with scaling and root planing in the treatment of periodontitis in rats submitted to chemotherapy.

Arch Oral Biol 2020 Jun 24;117:104825. Epub 2020 Jun 24.

Periodontics Division, Department of Diagnosis and Surgery, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, SP, Brazil. Electronic address:

Objective: The aim of this study was to evaluate the effects of Lactobacillus reuteri applied locally or systemically with scaling and root planing (SRP) to the treatment of experimental periodontitis (EP) in rats treated with 5-fluorouracil.

Methods: A cotton ligature was installed on the molars of rats. The animals (n = 54) underwent chemotherapy and were divided into groups: SRP (n = 18), scaling and root planing only; LP (n = 18), SRP and 4 sessions of local probiotic (PRO); SP, SRP and 4 sessions of systemic PRO. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104825DOI Listing

Antimicrobial effect of thymol and carvacrol added to a vinegar-based marinade for controlling spoilage of marinated beef (Shawarma) stored in air or vacuum packaging.

Int J Food Microbiol 2020 Jun 23;332:108769. Epub 2020 Jun 23.

Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Riad El Solh, 1107-2020, P.O. Box 11-0236, Beirut, Lebanon; Laboratory of Food Chemistry and Food Microbiology, Department of Chemistry, University of Ioannina, GR-45110 Ioannina, Greece.

Controlling spoilage of the popular ethnic marinated beef "Shawarma" is crucial to achieve high quality, extend shelf-life, reduce food waste and meet the need of the globalized supply chain. Active essential oil (EO) components (thymol and carvacrol) were added at 0.4% and 0. Read More

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http://dx.doi.org/10.1016/j.ijfoodmicro.2020.108769DOI Listing

Laparoscopic Versus Robotic Proctectomy Outcomes: An ACS-NSQIP Analysis.

J Surg Res 2020 Jul 1;255:495-501. Epub 2020 Jul 1.

Division of Colorectal Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address:

Background: The robotic platform is increasingly used in colorectal surgery. Recent upgrades in the robotic platform and introduction of proctectomy-specific reports from the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) warrant updated evaluation of minimally invasive proctectomy outcomes. The aim of this study was to compare outcomes in robotic versus laparoscopic proctectomy using ACS-NSQIP data. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.094DOI Listing

Predictors of Nonhome Discharge after Cytoreductive Surgery and HIPEC.

J Surg Res 2020 Jul 1;255:475-485. Epub 2020 Jul 1.

Department of Surgery, Johns Hopkins University, Baltimore, Maryland. Electronic address:

Background: Using a national database of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) recipients, we sought to determine risk factors for nonhome discharge (NHD) in a cohort of patients.

Methods: Patients undergoing CRS/HIPEC at any one of 12 participating sites between 2000 and 2017 were identified. Univariate analysis was used to compare the characteristics, operative variables, and postoperative complications of patients discharged home and patients with NHD. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.085DOI Listing

Discordance Between the American Thyroid Association and the American College of Radiology Guideline Systems for Thyroid Nodule Biopsy.

J Surg Res 2020 Jun 30;255:469-474. Epub 2020 Jun 30.

Division of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address:

Background: Previously, fine-needle aspiration biopsy was recommended for any thyroid nodule >1.0 cm in size. In 2015, the American Thyroid Association (ATA) introduced a pattern-based approach for biopsy recommendations based on size and ultrasound (US) characteristics. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.074DOI Listing

Bone density, microarchitecture and strength estimates in white versus African American youth with obesity.

Bone 2020 Jul 1;138:115514. Epub 2020 Jul 1.

Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America; Division of Pediatric Endocrinology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.

Background: African Americans (AA) have more favorable bone density and microarchitecture compared to Whites (W), which may explain their observed lower fracture rates. Obesity has deleterious effects on bone microarchitecture and strength estimates and is associated with an increase in fracture risk. Adolescence and young adulthood are periods of active bone accrual and also periods characterized by an increasing prevalence of obesity. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115514DOI Listing

Delta-like 1 (DLK1) is a possible mediator of vitamin D effects on bone and energy metabolism.

Bone 2020 Jul 1:115510. Epub 2020 Jul 1.

Calcium Metabolism and Osteoporosis Program, Division of Endocrinology and Metabolism, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Vitamin D effects on bone and mineral metabolism are well recognized, and its anti-inflammatory actions are gaining particular interest. Delta-like 1 (DLK1) is a protein, expressed by progenitor cells of different tissues, and increases the size of progenitor cell population during the inflammatory phase of tissue regeneration. DLK1 also plays a role in energy metabolism as it antagonizes insulin signaling in bone. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115510DOI Listing

Skin sensitization in silico protocol.

Regul Toxicol Pharmacol 2020 Jul 1:104688. Epub 2020 Jul 1.

Leadscope, Inc, 1393 Dublin Rd, Columbus, OH, 43215, USA.

The assessment of skin sensitization has evolved over the past few years to include in vitro assessments of key events along the adverse outcome pathway and opportunistically capitalize on the strengths of in silico methods to support a weight of evidence assessment without conducting a test in animals. While in silico methods vary greatly in their purpose and format; there is a need to standardize the underlying principles on which such models are developed and to make transparent the implications for the uncertainty in the overall assessment. In this contribution, the relationship of skin sensitization relevant effects, mechanisms, and endpoints are built into a hazard assessment framework. Read More

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http://dx.doi.org/10.1016/j.yrtph.2020.104688DOI Listing

Prevalence and Consequences of Perceived Vision Difficultyin Aging Adults with HIV-infection.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

Department of Medicine, Division of Infectious Diseases, Georgetown University, Washington DC.

Purpose: Despite well-known ocular complications of HIV-related immune suppression, few studies have examined the prevalence and consequences of visual impairment among aging long term survivors of HIV.

Design: Retrospective cohort study METHODS: Aging HIV-infected (HIV+) men who have sex with men (MSM) and -uninfected (HIV-) MSM controls reported their difficulty performing six vision-dependent tasks (no, a little, moderate, and extreme difficulty). Relationships were examined using logistic regression, regressing each outcome separately on categorical visual function responses, with missing data multiply imputed. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.018DOI Listing

Open Synthesis and the coronavirus (COVID-19) pandemic in 2020.

J Clin Epidemiol 2020 Jul 1. Epub 2020 Jul 1.

Department of Health Research Methods, Evidence, and Impact (HE&I), McMaster University, Hamilton, ON, Canada; The Global Evidence Synthesis Initiative (GESI) Secretariat, American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.1016/j.jclinepi.2020.06.032DOI Listing

Spatial predictors of genomic and phenotypic variation differ in a lowland Middle American bird (Icterus gularis).

Mol Ecol 2020 Jul 4. Epub 2020 Jul 4.

Department of Ornithology, American Museum of Natural History, Central Park West at 79th Street, New York, NY, 10024, USA.

Spatial patterns of intraspecific variation are shaped by factors such as geographic distance among populations, historical changes in gene flow and interactions with local environments. Although these factors are not mutually exclusive and operate on both genomic and phenotypic variation, it is unclear how they affect these two axes of variation. We address this question by exploring the predictors of genomic and phenotypic divergence in Icterus gularis, a broadly distributed Middle American bird that exhibits marked geographic variation in body size across its range. Read More

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http://dx.doi.org/10.1111/mec.15536DOI Listing

The readability of online patient information about laser resurfacing therapy.

Dermatol Online J 2020 Apr 15;26(4). Epub 2020 Apr 15.

Department of Dermatology, University of California Irvine, Irvine, CA.

Because there are important distinctions between ablative and non-ablative laser resurfacing, accurate and effective patient education is paramount. However, as more patients use the internet as a resource for medical information, little is known about the content and readability of these sources. Thus, we sought to evaluate the readability of major online resources about laser resurfacing while recognizing the recommendations by the American Medical Association and National Institutes of Health. Read More

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The role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a Position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC).

Eur J Heart Fail 2020 Jul 4. Epub 2020 Jul 4.

National Heart and Lung Institute, Imperial College, London, United Kingdom.

Cardiovascular (CV) imaging is an important tool in baseline risk assessment and detection of CV disease in oncology patients receiving cardiotoxic cancer therapies. This position statement examines the role of echocardiography, cardiac magnetic resonance, nuclear cardiac imaging and computed tomography in the management of cancer patients. The Imaging and Cardio-Oncology Study Groups of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in collaboration with the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the ESC have evaluated the current evidence for the value of modern CV imaging in the cardio-oncology field. Read More

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http://dx.doi.org/10.1002/ejhf.1957DOI Listing

Difficulties in achieving a sustainable blood supply: report from the first national seminar on blood donation in Lebanon.

East Mediterr Health J 2020 Jun 24;26(6):736-743. Epub 2020 Jun 24.

EA3064, Faculty of Medicine of Saint-Etienne, University of Lyon, Saint-Etienne, France.

Background: Lebanon has a decentralized/fragmented transfusion system. The current blood supply does not meet the World Health Organization target of achieving 100% voluntary non-remunerated blood donation (VNRD). There are currently 3 types of donors/donations in Lebanon: replacement/family donations (70-75%), VNRD (20-25%), and compensated donations (5-10%). Read More

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http://dx.doi.org/10.26719/emhj.19.070DOI Listing

[Brief Introduction to Regulatory Documents of European and American Drug-Device Combinations and Enlightenment].

Zhongguo Yi Liao Qi Xie Za Zhi 2020 Mar;44(3):246-248

Center for Medical Device Evaluation, NMPA, Beijing, 100081.

This paper briefly introduces the recent regulatory regulations issued by the European Union and the United States on the drug-device combinations. The contents include the definition of drug-device combinations, the attribute definition process, the registration requirements, the review and approval procedures, the management of production systems, and the post-marketing safety supervision. Some inspirations have been obtained from them for reference by the regulatory authorities. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2020.03.012DOI Listing

Primary Care Physicians' Knowledge of the Cardiovascular Effects of Diabetes Medications: Findings from an Online Survey.

Adv Ther 2020 Jul 4. Epub 2020 Jul 4.

University of California, San Diego, CA, USA.

Introduction: Cardiovascular (CV) outcomes trial (CVOT) results have led to changes in indications for some glucose-lowering agents, with recommendations based on the presence of comorbidities.

Objective: This study aimed to understand internal medicine (IM) and family medicine (FM) physicians' knowledge of CVOTs and beliefs about type 2 diabetes mellitus (T2DM) medications, excluding insulin, for CV disease risk reduction.

Methods: WebMD, LLC, fielded a 23-item online survey from September 18 to 20, 2018, to 47,534 Medscape members (US IM and FM physicians) who were invited to participate via e-mail (quota = 500). Read More

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http://dx.doi.org/10.1007/s12325-020-01405-yDOI Listing