428,796 results match your criteria American Journal Of Mathematics[Journal]

Efferent Activity Controls Hair Cell Response to Mechanical Overstimulation.

eNeuro 2022 Jun 27. Epub 2022 Jun 27.

Department of Physics and Astronomy, UCLA, Los Angeles, CA 90095

The efferent pathway strengthens the auditory system for optimal performance by fine-tuning the response and protecting the inner ear from noise-induced damage. Although it has been well-documented that efference helps defend against hair cell and synaptic extinction, the mechanisms of its otoprotective role have still not been established. Specifically, the effect of efference on an individual hair cell's recovery from mechanical overstimulation has not been demonstrated. Read More

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Non-ischaemic cardiomyopathy associated with elevated serum cobalt and accelerated wear of a metal-on-metal hip resurfacing.

BMJ Case Rep 2022 Jun 27;15(6). Epub 2022 Jun 27.

Orthopaedic Surgery, Henry Ford Health System, Detroit, Michigan, USA.

A man in his late 30s developed non-ischaemic cardiomyopathy due to systemic cobalt toxicity associated with accelerated bearing surface wear from metal-on-metal hip resurfacing implanted in the previous 6 years. Following revision arthroplasty, the patient regained baseline cardiac function. Cobalt-induced cardiomyopathy is a grave condition that deserves early consideration due to potentially irreversible morbidity. Read More

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Biomarker underuse contributes to an inability to phenotype patients with severe uncontrolled asthma.

Allergy Asthma Proc 2022 Jun 27. Epub 2022 Jun 27.

Background: Biomarker measurements improve the phenotyping of patients with severe uncontrolled asthma (SUA) and predict therapeutic responses. The use of biomarkers in asthma, however, remains underused.

Objective: To test the hypothesis that biomarker measurements of patients with SUA remain markedly underused and contributes to asthma morbidity and oral corticosteroid use. Read More

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Clinical Presentation, Treatment Outcomes, and Resistance-related Factors in South American Women with Low-risk Postmolar Gestational Trophoblastic Neoplasia.

Rev Bras Ginecol Obstet 2022 Jun 27. Epub 2022 Jun 27.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, New England Trophoblastic Disease Centre, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.

Objective:  There are few multinational studies on gestational trophoblastic neoplasia (GTN) treatment outcomes in South America. The purpose of this study was to assess the clinical presentation, treatment outcomes, and factors associated with chemoresistance in low-risk postmolar GTN treated with first-line single-agent chemotherapy in three South American centers.

Methods:  Multicentric, historical cohort study including women with International Federation of Gynecology and Obstetrics (FIGO)-staged low-risk postmolar GTN attending centers in Argentina, Brazil, and Colombia between 1990 and 2014. Read More

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Scientific evidence of the duration of antibiotic treatment in intra-abdominal infections with surgical focus control.

Cir Esp (Engl Ed) 2022 Jun 24. Epub 2022 Jun 24.

Servicio de Cirugía General y Aparato Digestivo, Hospital del Mar de Barcelona, Spain.

A non-systematic review of the published scientific evidence has been carried out on the duration of empirical antibiotic treatment in surgical intra-abdominal infections (IIA) with effective focus control. Given the progressive increase in antibiotic resistance, it is urgent to have strategies to reduce the pressure on the microbiota. The American guidelines made by Mazuski et al. Read More

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Liberation from Mechanical Ventilation: Established and New Insights.

Semin Respir Crit Care Med 2022 Jun 27. Epub 2022 Jun 27.

The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

A substantial proportion of critically ill patients require ventilator support with the majority requiring invasive mechanical ventilation. Timely and safe liberation from invasive mechanical ventilation is a critical aspect of patient care in the intensive care unit (ICU) and is a top research priority for patients and clinicians. In this article, we discuss how to (1) identify candidates for liberation from mechanical ventilation, (2) conduct spontaneous breathing trials (SBTs), and (3) optimize patients for liberation from mechanical ventilation. Read More

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Implementation of the Vascular Surgery Board Virtual Certifying Examination.

J Vasc Surg 2022 Jun 24. Epub 2022 Jun 24.

University of Florida College of Medicine.

Objective: COVID mandated postponement of the in-person Vascular Surgery Board 2020 certifying examination (CE). Vascular Surgery Virtual CEs (VVCEs) were developed for the scheduled 2020 (rescheduled 1/21) and 2021 (rescheduled 7/21) CEs to avoid postponing the certification testing. This study reports the development, implementation and outcome of the first two VVCEs. Read More

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Assessing the Quality of Reporting of Studies Using Vascular Quality Initiative (VQI) Data.

J Vasc Surg 2022 Jun 24. Epub 2022 Jun 24.

Department of Surgery, University of Florida College of Medicine, Gainesville, Florida.

Objective: The Society for Vascular Surgery (SVS) Vascular Quality Initiative (VQI) has become an increasingly popular data source for retrospective observational vascular surgery studies. There are published guidelines on the reporting of data in such studies to promote transparency and rigor, but these have not been used to evaluate studies using VQI data. Our objective was to appraise the methodological reporting quality of studies using VQI data by evaluating their adherence to these guidelines. Read More

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Serious reporting deficiencies exist in minimal important difference studies: Current state and suggestions for improvement.

J Clin Epidemiol 2022 Jun 24. Epub 2022 Jun 24.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. 1280 Main St East, Hamilton, Canada, L8S 4L8; Department of Medicine, McMaster University, Hamilton, Canada. 1280 Main St East, Hamilton, Canada, L8S 4L8.

Objective: To evaluate reporting of minimal important difference (MID) estimates using anchor-based methods for patient-reported outcome measures (PROMs), and the association with reporting deficiencies on their credibility.

Study Design And Setting: Systematic survey of primary studies empirically estimating MIDs. We searched Medline, EMBASE, PsycINFO, and the Patient-Reported Outcome and Quality of Life Instruments Database until October 2018. Read More

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Serum and Urine Osmolality as Predictors of Adequate Diuresis in Acute Decompensated Heart Failure: A Prospective Cohort Study.

Cardiorenal Med 2022 Jun 27. Epub 2022 Jun 27.

Background Determination of adequacy of decongestion remains a significant challenge in the management of acute heart failure (AHF). Methods This is a prospective single center cohort study of patients (>18 years old) admitted for AHF on intravenous diuretics, with BNP > 100 pg/mL or echocardiographic findings of reduced ejection fraction or diastolic dysfunction, and at least 1 clinical sign of volume overload. Patients with eGFR≤45mL/minute or on dialysis, and with exposure to contrast dye or nephrotoxins were excluded. Read More

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Gender and Racial/Ethnic Disparities in Operative Volumes of Graduating General Surgery Residents.

J Surg Res 2022 Jun 24;279:104-112. Epub 2022 Jun 24.

Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Introduction: Gender disparities in resident operative experience have been described; however, their etiology is poorly understood, and racial/ethnic disparities have not been explored. This study investigated the relationship between gender, race/ethnicity, and surgery resident case volumes.

Materials And Methods: A retrospective analysis of graduating general surgery resident case logs (2010-2020) at an academic medical center was performed. Read More

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A comprehensive insight on modern green analyses for quality control determination and processing monitoring in coffee and cocoa seeds.

Food Chem 2022 Jun 18;394:133529. Epub 2022 Jun 18.

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. Electronic address:

Green analysis is defined as the analysis of chemicals in a manner where sample extraction and analysis are performed with least amounts of steps, low hazardous materials, while maintaining efficiency in terms of analytes detection. Coffee and cocoa represent two of the most popular and valued beverages worldwide in addition to their several products i.e. Read More

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Trust but Verify: Misrepresentation of Publication Records Among Child Neurology Residency Applicants.

Pediatr Neurol 2022 Jun 9;133:63-66. Epub 2022 Jun 9.

Division of Neurology and Center for Pediatric Bioethics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio. Electronic address:

Introduction: Numerous authors have reported that misrepresentation of publication records among residency applicants is not uncommon. We sought to determine the percentage of child neurology residency applicants who falsify information about publications in the documents submitted to the Electronic Residency Application Service.

Methods: The records of applicants to our residency program between 2014 and 2020 (898 individuals) were analyzed. Read More

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Length of Stay and 30-Day Postoperative Complications Following Minimally Invasive Apical Prolapse Repair.

Female Pelvic Med Reconstr Surg 2022 Jun 18. Epub 2022 Jun 18.

Division of Minimally Invasive Gynecologic Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

Importance: Data on the correlation between length of stay and postoperative complications following urogynecologic surgery are limited.

Objectives: The objective of this study was to use a nationwide database to examine the correlation between length of stay and 30-day postoperative complications following minimally invasive apical prolapse repair.

Study Design: This retrospective cohort study included women in the American College of Surgeons National Surgical Quality Improvement Program database from 2008 to 2018 who underwent laparoscopic/robotic sacrocolpopexy or uterosacral/sacrospinous repair and were discharged on postoperative day 0 (POD0) or 1 (POD1). Read More

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Strengthening Food and Nutrition Security to Promote Public Health in the United States: A Position Paper From the American College of Physicians.

Ann Intern Med 2022 Jun 28. Epub 2022 Jun 28.

Hennepin Healthcare, Minneapolis, Minnesota (D.H.).

Food insecurity functions as a social driver of health, directly negatively impacting health status and outcomes, which can further negatively impact employment and income and increase medical expenditures-all of which exacerbates food insecurity. Progress in meaningfully reducing the food-insecurity rate has stalled in recent years. Although rates have decreased since their peak during the Great Recession, these gains have been reversed by the economic implications of the COVID-19 pandemic. Read More

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Medicare Codes for Primary Care: Expansions With Limitations.

Davoren Chick

Ann Intern Med 2022 Jun 28. Epub 2022 Jun 28.

American College of Physicians, Philadelphia, Pennsylvania (D.C.).

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Feasibility of ultrasound tomography-guided localized mild hyperthermia using ring transducer: Ex vivo and In silico studies.

Med Phys 2022 Jun 27. Epub 2022 Jun 27.

Department of Biomedical Engineering, Wayne State University, Detroit, Michigan, 48202, USA.

Background: As of 2022, breast cancer continues to be the most diagnosed cancer worldwide. This problem persists within the U.S as well, as the American Cancer Society has reported that approximately 12. Read More

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Antibody Response to COVID-19 mRNA Vaccine in Patients With Lung Cancer After Primary Immunization and Booster: Reactivity to the SARS-CoV-2 WT Virus and Omicron Variant.

J Clin Oncol 2022 Jun 27:JCO2102986. Epub 2022 Jun 27.

Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA.

Purpose: To examine COVID-19 mRNA vaccine-induced binding and neutralizing antibody responses in patients with non-small-cell lung cancer (NSCLC) to SARS-CoV-2 614D (wild type [WT]) strain and variants of concern after the primary 2-dose and booster vaccination.

Methods: Eighty-two patients with NSCLC and 53 healthy volunteers who received SARS-CoV-2 mRNA vaccines were included in the study. Blood was collected longitudinally, and SARS-CoV-2-specific binding and neutralizing antibody responses were evaluated by Meso Scale Discovery assay and live virus Focus Reduction Neutralization Assay, respectively. Read More

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Biomarkers for Systemic Therapy in Metastatic Breast Cancer: ASCO Guideline Update.

J Clin Oncol 2022 Jun 27:JCO2201063. Epub 2022 Jun 27.

University of Pennsylvania, Philadelphia, PA.

Purpose: To update the ASCO biomarkers to guide systemic therapy for metastatic breast cancer (MBC) guideline.

Methods: An Expert Panel conducted a systematic review to identify randomized clinical trials and prospective-retrospective studies from January 2015 to January 2022.

Results: The search identified 19 studies informing the evidence base. Read More

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Can Alternative Payment Models And Value-Based Insurance Design Alter The Course Of Diabetes In The United States?

Health Aff (Millwood) 2022 Jun 27:101377hlthaff202200235. Epub 2022 Jun 27.

Elbert S. Huang University of Chicago.

Diabetes process and outcome measures are common quality measures in payment reform models, including Alternative Payment Models (APMs) and value-based insurance design (VBID). In this commentary we review evidence from selected research to examine whether these payment models can improve the value of diabetes care. We found that higher-risk APMs yielded greater improvements in diabetes process measures than lower-risk APMs, and that VBID models appeared to improve medication adherence but not other quality measures. Read More

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Clinical Benefits of Early Concurrent Use of Cryoprecipitate and Plasma Compared With Plasma Only in Bleeding Trauma Patients.

Crit Care Med 2022 Jun 20. Epub 2022 Jun 20.

Riverside University Health System-Comparative Effectiveness and Clinical Outcomes Research Center, Moreno Valley, CA.

Objectives: The effectiveness of cryoprecipitate (Cryo) in trauma has not been well established; the benefits of Cryo might have been overestimated in previous studies since the difference in the total amount of administered clotting factors was not considered. We aimed to evaluate the benefits of the concurrent use of Cryo in combination with fresh frozen plasma (FFP) for bleeding trauma patients.

Design: Retrospective cohort study. Read More

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Molecular Mechanisms of Hepatic Dysfunction in Sickle Cell Disease: Lessons From The Townes Mouse Model.

Am J Physiol Cell Physiol 2022 Jun 27. Epub 2022 Jun 27.

Pittsburgh Heart, Liver and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Sickle cell disease (SCD) is an autosomal-recessive-genetic disorder that affects ~100,000 Americans and millions of people worldwide. Erythrocyte sickling, vaso-occlusion, sterile inflammation and hemolysis are the major pathophysiological pathways leading to liver injury in SCD. Although hepatic dysfunction affects up to 10-40% of SCD patients, therapeutic approaches to prevent liver injury in SCD are not known, and the molecular mechanisms promoting progressive liver injury in SCD remain poorly understood. Read More

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Current epidemiological profile and characteristics of traumatic cervical spinal cord injury in Nanchang, China.

J Spinal Cord Med 2022 Jul;45(4):556-563

Department of Orthopedics, The First Affiliated Hospital of Nanchang University, College of Medicine, Nanchang, Jiangxi, People's Republic of China.

Study Design: A hospital-based retrospective epidemiological study.

Objective: To describe the recent epidemiological profile and characteristics of traumatic cervical spinal cord injury (TCSCI) in Nanchang, Jiangxi Province, China.

Setting: The First Affiliated Hospital of Nanchang University, The Second Affiliated Hospital of Nanchang University and The Third Affiliated Hospital of Nanchang University. Read More

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Near-Peer Facilitation of a Soft Skills Program for Young Adults With Autism.

Am J Occup Ther 2022 Jul;76(4)

Connie Sung, PhD, CRC, LPC, is Associate Professor, Department of Counseling, Educational Psychology & Special Education, Michigan State University, East Lansing.

Importance: Young adults with autism spectrum disorder (ASD) experience poor employment outcomes. Teaching soft skills and using peer-based interventions improve outcomes for people with ASD.

Objective: To evaluate the preliminary efficacy of a soft skills intervention and the feasibility of delivery to a group of young adults with ASD by near-peer occupational therapy master's-level students. Read More

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"I Beat Cancer to Feel Sick:" Qualitative Experiences of Sleep Disturbance in Black Breast Cancer Survivors and Recommendations for Culturally Targeted Sleep Interventions.

Ann Behav Med 2022 Jun 27. Epub 2022 Jun 27.

Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA.

Background: Sleep disturbance is common and distressing among cancer survivors. Black breast cancer survivors (BBCS) suffer disproportionately from sleep disturbance, yet there is limited research on how to address this issue.

Purpose: This study aimed to understand the multifaceted experiences of sleep disturbance among BBCS and how to culturally target a mobile health (mHealth) intervention to improve sleep outcomes in BBCS. Read More

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Diagnosis of heart failure in the elderly: current status and future perspectives for echocardiographic diagnostic systems.

Yoshihiro Seo

J Med Ultrason (2001) 2022 Jun 27. Epub 2022 Jun 27.

Department of Cardiology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.

Since Japan is experiencing a super-aged society, the number of heart failure patients (HF) is increasing remarkably. In particular, the increase in heart failure with preserved ejection fraction (HFpEF), which is common in the elderly, has characterized the last decade. The diagnosis of HFpEF by assessment of left ventricular (LV) diastolic dysfunction, which is also referred to as diastolic heart failure, is an important role assigned to echocardiography. Read More

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Proceedings of the fifth international Molecular Pathological Epidemiology (MPE) meeting.

Cancer Causes Control 2022 Jun 27. Epub 2022 Jun 27.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Cancer heterogeneities hold the key to a deeper understanding of cancer etiology and progression and the discovery of more precise cancer therapy. Modern pathological and molecular technologies offer a powerful set of tools to profile tumor heterogeneities at multiple levels in large patient populations, from DNA to RNA, protein and epigenetics, and from tumor tissues to tumor microenvironment and liquid biopsy. When coupled with well-validated epidemiologic methodology and well-characterized epidemiologic resources, the rich tumor pathological and molecular tumor information provide new research opportunities at an unprecedented breadth and depth. Read More

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Variants in genes coding for collagen type IV α-chains are frequent causes of persistent, isolated hematuria during childhood.

Pediatr Nephrol 2022 Jun 27. Epub 2022 Jun 27.

Department of Pediatrics, Division of Pediatric Nephrology, Baylor College Medicine, Houston, TX, 77030, USA.

Background: Children with persistent, isolated microscopic hematuria typically undergo a limited diagnostic workup and are monitored for signs of kidney disease in long-term longitudinal follow-up, which can delay diagnosis and allow disease progression in some cases.

Methods: To determine the clinical utility of genetic screening in this population, we performed targeted genetic testing using a custom, 32-gene next-generation sequencing panel for progressive kidney disease on children referred to the Texas Children's Hospital Pediatric Nephrology clinic for persistent, microscopic hematuria (n = 30; cohort 1). Patients with microscopic hematuria identified by urinalysis on at least two separate occasions were eligible for enrollment, but those with other evidence of kidney disease were excluded. Read More

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