11,719 results match your criteria American Journal Of Kidney Diseases[Journal]


Patient and Caregiver Priorities for Outcomes in CKD: A Multinational Nominal Group Technique Study.

Am J Kidney Dis 2020 May 31. Epub 2020 May 31.

Sydney School of Public Health, The University of Sydney, Sydney, NSW, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, NSW, Australia.

Rationale And Objective: Patients with chronic kidney disease (CKD) are at an increased risk of premature death, cardiovascular disease, and burdensome symptoms that impair quality of life. We aimed to identify patient and caregiver priorities for outcomes in CKD.

Study Design: Focus groups with nominal group technique SETTING: and Participants: Adult patients with CKD (all stages) and caregivers in the United States, Australia, and United Kingdom. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.03.022DOI Listing

Particulate Air Pollution and Progression to Kidney Failure With Replacement Therapy: An Advanced CKD Registry-Based Cohort Study in Taiwan.

Am J Kidney Dis 2020 May 29. Epub 2020 May 29.

Department of Occupational Safety and Health, College of Public Health, China Medical University, Taichung; Department of Occupational Therapy, College of Medical and Health Science, Asia University, Taichung, Taiwan. Electronic address:

Rationale & Objective: Limited evidence concerns fine particulate matter (with aerodynamic diameter ≤ 2.5μm [PM]) exposure and the risk for kidney failure with replacement therapy (KFRT). This study assessed whether PM exposure was associated with progression of chronic kidney disease (CKD) to KFRT. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.02.447DOI Listing

Outpatient Interventions for Managing Acute Complications of Chronic Diseases: A Scoping Review and Implications for Patients With CKD.

Am J Kidney Dis 2020 May 29. Epub 2020 May 29.

Department of Community Health Sciences, University of Calgary, Calgary, AB.

Rationale & Objective: Patients with chronic kidney disease (CKD) have high rates of emergency department (ED) use and hospitalization. Outpatient care may provide an alternative to ED and inpatient care in this population. We aimed to explore the scope of outpatient interventions used to manage acute complications of chronic diseases and highlight opportunities to adapt and test interventions in the CKD population. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.04.006DOI Listing

Pseudohypobicarbonatemia in Severe Hypertriglyceridemia.

Am J Kidney Dis 2020 May 29. Epub 2020 May 29.

The University of Queensland - Ochsner Clinical School, New Orleans, LA, USA; Nephrology, Ochsner Health System, New Orleans, LA, USA. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2020.04.007DOI Listing

Trends in Transplantation Center Use of Kidneys From Deceased Donors With Positive Hepatitis C Nucleic Acid Amplification Testing.

Am J Kidney Dis 2020 May 29. Epub 2020 May 29.

Department of Medicine, Division of Nephrology, Columbia University Medical Center, New York, NY, USA; Columbia University Renal Epidemiology (CURE) Group, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2020.04.008DOI Listing

NSAIDs in CKD: Are They Safe?

Am J Kidney Dis 2020 May 29. Epub 2020 May 29.

Section of Nephrology, Department of Medicine, Yale University School of Medicine, BB114 330 Cedar Street New Haven, CT 06410. Electronic address:

The management of pain in patients with chronic kidney disease (CKD) is challenging for many reasons. These patients have an increased susceptibility to adverse drug effects due to altered drug metabolism and excretion, and there are limited safety data for use in this population despite a high pain burden. Non-steroidal anti-inflammatory drugs (NSAIDs) have long been regarded as dangerous for use in chronic kidney disease patients because of their risk for nephrotoxicity, and thus alternative classes of analgesics, including opioids, have become more commonly used for pain control in this population. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.03.023DOI Listing

Kidney Infarction in Patients With COVID-19.

Am J Kidney Dis 2020 May 29. Epub 2020 May 29.

Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Coronavirus disease 2019 (COVID-19) is a contagious, life-threatening infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Recent findings indicate an increased risk of acute kidney injury during COVID-19. The pathophysiological mechanisms leading to acute kidney injury in COVID-19 are unclear, but may include direct cytopathic effects of the virus on kidney tubular and endothelial cells, indirect damage caused by virus-induced cytokine release, and kidney hypoperfusion due to a restrictive fluid strategy. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258815PMC

Erythropoiesis-Stimulating Agent Treatment in Patients With COVID-19.

Am J Kidney Dis 2020 May 29. Epub 2020 May 29.

Donald and Barbara Zucker School of Medicine at Hofstra / Northwell Health, Department of Medicine, Division of Kidney Diseases and Hypertension, Great Neck, NY.

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http://dx.doi.org/10.1053/j.ajkd.2020.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256552PMC

Comparative Effectiveness of Calcimimetic Agents for Secondary Hyperparathyroidism in Adults: A Systematic Review and Network Meta-analysis.

Am J Kidney Dis 2020 May 28. Epub 2020 May 28.

Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy; Sydney School of Public Health, The University of Sydney, NSW, Australia. Electronic address:

Rationale & Objective: Comparative benefits and harms of calcimimetic agents used for the treatment of secondary hyperparathyroidism have not been well characterized. We sought to compare the effectiveness of 3 calcimimetic agents using published data.

Study Design: Systematic review of randomized controlled trials and network meta-analysis. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.02.439DOI Listing

Fatherhood and Kidney Replacement Therapy: Analysis of the Australian and New Zealand Dialysis and Transplantation (ANZDATA) Registry.

Am J Kidney Dis 2020 May 28. Epub 2020 May 28.

Central and Northern Adelaide Renal and Transplantation Services (CNARTS), Royal Adelaide Hospital, Adelaide, South Australia; Australian and New Zealand Dialysis and Transplant (ANZDATA) registry and Australia and New Zealand Organ Donation (ANZOD) registry, South Australian Health & Medical Research Institute (SAHMRI), Adelaide, South Australia; Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia.

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http://dx.doi.org/10.1053/j.ajkd.2020.03.020DOI Listing

Outcomes Following Ischemic Stroke in Older Patients With CKD Stages 4 and 5: A Retrospective Cohort Study.

Am J Kidney Dis 2020 May 28. Epub 2020 May 28.

Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania.

Rationale & Objective: The associations between ischemic stroke and time to dialysis initiation and/or death in adults with late-stage chronic kidney disease (CKD) have not been explored. We sought to measure the rate and factors associated with stroke in CKD stages 4 and 5 and to assess the association of stroke with initiation of dialysis and death.

Study Design: Retrospective cohort SETTING & PARTICIPANTS: Patients with CKD4-5 in Medicare, 2007-2014 EXPOSURE OR PREDICTOR: Ischemic stroke in CKD4-5. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.03.021DOI Listing

Hypothyroidism Due to Iodine Overload in Children Receiving Peritoneal Dialysis: A Report of 4 Cases.

Am J Kidney Dis 2020 May 26. Epub 2020 May 26.

Division of Nephrology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL.

Children who receive peritoneal dialysis (PD) are at increased risk for thyroid dysfunction. A rarely appreciated cause is iodine overload. We report 4 children who developed iodine overload and secondary hypothyroidism. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.02.448DOI Listing

Acute Kidney Injury Events in Patients With Type 2 Diabetes Using SGLT2 Inhibitors Versus Other Glucose-Lowering Drugs: A Retrospective Cohort Study.

Am J Kidney Dis 2020 May 25. Epub 2020 May 25.

University of Manitoba, Rady Faculty of Health Sciences, Max Rady College of Medicine, Department of Internal Medicine; Seven Oaks Hospital, Chronic Disease Innovation Centre.

Rationale & Objective: Sodium glucose cotransporter 2 (SGLT2) inhibitors slow the progression of chronic kidney disease and prevent heart failure events. However, SGLT2 inhibitors may increase the risk of acute kidney injury (AKI). Our objective was to assess whether SGLT2 inhibitor use, compared to all other glucose lowering drugs (oGLD), is associated with increased rates of AKI. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.03.019DOI Listing

Elevated Renin and Aldosterone Levels in a Young Woman With Hypertension.

Am J Kidney Dis 2020 Jun;75(6):A11-A13

Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2020.01.016DOI Listing

Home Dialysis Training for Fellows: Privilege or Necessity?

Am J Kidney Dis 2020 May 19. Epub 2020 May 19.

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

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http://dx.doi.org/10.1053/j.ajkd.2020.02.443DOI Listing
May 2020
5.900 Impact Factor

Targeting Zero Infections in the Outpatient Dialysis Unit: Core Curriculum 2020.

Am J Kidney Dis 2020 May 19. Epub 2020 May 19.

Division of Nephrology and Hypertension, Saint Louis University School of Medicine, St. Louis, MO.

Although overall mortality rates in dialysis patients have improved during the last decade or so, infections remain a leading cause of death, second only to cardiovascular disease. In addition, infections account for a major share of hospitalizations in this patient population. Receiving hemodialysis treatments in an outpatient dialysis facility significantly contributes to patients' risks for infection. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.02.441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237370PMC

Can We Assess Interventions to Prevent Kidney Disease?

Am J Kidney Dis 2020 May 19. Epub 2020 May 19.

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai; and The National Kidney Foundation, Inc, New York, NY. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2020.01.014DOI Listing

Arteriolar C4d in IgA Nephropathy: A Cohort Study.

Am J Kidney Dis 2020 May 18. Epub 2020 May 18.

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Rationale & Objective: Glomerular C4d (C4dG) as an indicator of lectin pathway of complement activation in IgA nephropathy (IgAN) has been associated with more severe kidney damage. Recent studies have suggested that vascular lesions in IgAN biopsies with complement deposition are also associated with disease progression. We aimed to study the clinical significance of arteriolar C4d (C4dA) in IgAN kidney biopsy tissue. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.03.017DOI Listing

Albuminuria and Estimated GFR as Risk Factors of Dementia in Midlife and Older Age: Findings From the ARIC Study.

Am J Kidney Dis 2020 May 16. Epub 2020 May 16.

Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States; Stanley Steyer School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Rationale & Objective: Evidence is limited on how estimated glomerular filtration rate (eGFR) and urine albumin-creatinine-ratio (UACR) relate to dementia at different ages. We evaluated eGFR and UACR in midlife and older age as risk factors for dementia. Additionally, we assessed whether the association between eGFR and dementia was altered when cystatin-C and beta-2-microglobulin (B2M) were used for GFR estimation. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.03.015DOI Listing

Safety and Efficacy of Immune Checkpoint Inhibitors in Patients on Dialysis: A Retrospective Case Series.

Am J Kidney Dis 2020 May 14. Epub 2020 May 14.

Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, MA. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2020.02.451DOI Listing

Recurrence of DNAJB9-Positive Fibrillary Glomerulonephritis After Kidney Transplantation: A Case Series.

Am J Kidney Dis 2020 May 12. Epub 2020 May 12.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. Electronic address:

Rationale & Objective: Fibrillary glomerulonephritis (FGN) is a rare glomerular disease that often progresses to kidney failure requiring kidney replacement therapy. We have recently identified a novel biomarker of FGN, DnaJ homolog subfamily B member 9 (DNAJB9). In this study, we used sequential protocol allograft biopsies and DNAJB9 staining to help characterize a series of patients with native kidney FGN who underwent kidney transplantation. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.01.018DOI Listing

Establishing Core Cardiovascular Outcome Measures for Trials in Hemodialysis: Report of an International Consensus Workshop.

Am J Kidney Dis 2020 May 12. Epub 2020 May 12.

Department of Renal Medicine, University College London, London, United Kingdom.

Cardiovascular disease (CVD) affects more than two-thirds of patients receiving hemodialysis and is the leading cause of death in this population, yet CVD outcomes are infrequently and inconsistently reported in trials in patients receiving hemodialysis. As part of the Standardised Outcomes in Nephrology-Haemodialysis (SONG-HD) initiative, we convened a consensus workshop to discuss the potential use of myocardial infarction and sudden cardiac death as core outcome measures for CVD for use in all trials in people receiving hemodialysis. Eight patients or caregivers and 46 health professionals from 15 countries discussed selection and implementation of the proposed core outcome measures. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.01.022DOI Listing

Dialysis Care for Undocumented Immigrants With Kidney Failure in the COVID-19 Era: Public Health Implications and Policy Recommendations.

Am J Kidney Dis 2020 May 12. Epub 2020 May 12.

Division of Hospital Medicine and Office of Research, Denver Health; Division of General Internal Medicine and Hospital Medicine, University of Colorado.

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http://dx.doi.org/10.1053/j.ajkd.2020.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217077PMC

Should Renin-Angiotensin System Blockade Be Avoided in Patients With Declining Kidney Function?

Am J Kidney Dis 2020 May 11. Epub 2020 May 11.

Division of Nephrology, Department of Medicine, University of California San Francisco; Division of Nephrology, Department of Pediatrics, University of California, San Francisco and Department of Epidemiology and Biostatistics.

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http://dx.doi.org/10.1053/j.ajkd.2020.04.003DOI Listing

Adiposity, Sex, and Cardiovascular Disease Risk in Children With CKD: A Longitudinal Study of Youth Enrolled in the Chronic Kidney Disease in Children (CKiD) Study.

Am J Kidney Dis 2020 May 5. Epub 2020 May 5.

Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Rationale & Objective: Traditional and nontraditional cardiovascular disease risk factors are highly prevalent in children with chronic kidney disease (CKD). We examined the longitudinal association of adiposity with cardiac damage among children with CKD and explored whether this association was modified by sex.

Study Design: Prospective cohort study. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.01.011DOI Listing

Obesity and Cardiovascular Outcomes in Children With CKD: Does Sex Matter?

Am J Kidney Dis 2020 May 5. Epub 2020 May 5.

Division of Nephrology, Children's National Hospital, Washington, DC.

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http://dx.doi.org/10.1053/j.ajkd.2020.02.440DOI Listing

Association of NT-proBNP and BNP With Future Clinical Outcomes in Patients With ESKD: A Systematic Review and Meta-analysis.

Am J Kidney Dis 2020 May 6. Epub 2020 May 6.

Departments of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Rationale & Objective: Use of brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) for cardiovascular (CV) risk assessment in patients with end-stage kidney disease (ESKD) remains unclear. We examined the associations between different threshold elevations of these peptide levels and clinical outcomes in patients with ESKD.

Study Design: Systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.12.017DOI Listing

eVisits in Rural Hemodialysis Care: A Qualitative Study of Stakeholder Perspectives on Design and Potential Impact to Care.

Am J Kidney Dis 2020 May 5. Epub 2020 May 5.

Department of Medicine, University of Calgary, Calgary. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2020.01.021DOI Listing

Blunted Glomerular Hyperfiltration in Pregnancy and Risk of Adverse Perinatal Outcomes.

Am J Kidney Dis 2020 May 5. Epub 2020 May 5.

Department of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/j.ajkd.2020.02.437DOI Listing

Metabolomic Markers of Kidney Function Decline in Patients With Diabetes: Evidence From the Chronic Renal Insufficiency Cohort (CRIC) Study.

Am J Kidney Dis 2020 May 5. Epub 2020 May 5.

Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA; Moores Cancer Center, University of California, San Diego, La Jolla, CA. Electronic address:

Rationale & Objective: Biomarkers that provide reliable evidence of future diabetic kidney disease (DKD) are needed to improve disease management. In a cross-sectional study, we previously identified 13 urine metabolites that had levels reduced in DKD compared with healthy controls. We evaluated associations of these 13 metabolites with future DKD progression. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.01.019DOI Listing

Osmotic Nephrosis and Acute Kidney Injury Associated With SGLT2 Inhibitor Use: A Case Report.

Am J Kidney Dis 2020 May 5. Epub 2020 May 5.

University of Colorado Anschutz Medical Campus, Aurora, CO. Electronic address:

We report a case of a patient who developed dialysis-requiring acute kidney injury (AKI) after the use of canagliflozin. A 66-year-old man with type 2 diabetes who was recovering from left knee septic arthritis at a rehabilitation facility was admitted with oliguric AKI 5 days after starting treatment with canagliflozin, an inhibitor of sodium/glucose cotransporter 2 (SGLT2). The patient presented with hematuria, non-nephrotic-range proteinuria, and serum creatinine level of 6. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.01.015DOI Listing
May 2020
5.900 Impact Factor

Incidence of ESKD Among Native Hawaiians and Pacific Islanders Living in the 50 US States and Pacific Island Territories.

Am J Kidney Dis 2020 May 5. Epub 2020 May 5.

Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI; Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, MI; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI. Electronic address:

Rationale & Objective: Native Hawaiians and Pacific Islanders (NHPI) have been reported to have the highest rates of incident end-stage kidney disease (ESKD) compared with other races in the United States. However, these estimates were likely biased upward due to the exclusion of nearly half the NHPI population that reports multiple races in the US Census. We sought to estimate the incidence rate of ESKD, including individuals reporting multiple races, and describe the clinical characteristics of incident cases by race and location. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.01.008DOI Listing

Kidney Biopsies in Elderly Chinese Patients: A Nationwide Survey.

Am J Kidney Dis 2020 Apr 30. Epub 2020 Apr 30.

National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2020.02.438DOI Listing

Medication Therapy Management in Dialysis Facilities: Can This Be an Answer to Reducing Hospital Readmissions?

Authors:
Wendy L St Peter

Am J Kidney Dis 2020 Apr 30. Epub 2020 Apr 30.

College of Pharmacy, University of Minnesota, Minneapolis, MN. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2020.01.020DOI Listing

Glomerular Filtration Rate and Supraphysiologic-Dose Anabolic-Androgenic Steroid Use: A Cross-sectional Cohort Study.

Am J Kidney Dis 2020 Apr 30. Epub 2020 Apr 30.

Department of Medicine, Harvard Medical School, Boston, MA; Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA; Section of Nephrology, Boston University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1053/j.ajkd.2020.01.012DOI Listing

Moving Away From Measuring Serum Urea Nitrogen to Estimate Dialyzer Urea Clearance: Technological Panacea or Curio?

Authors:
Andrew Davenport

Am J Kidney Dis 2020 Apr 30. Epub 2020 Apr 30.

University College London Centre for Nephrology, Royal Free Hospital, University College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2020.01.017DOI Listing

Core Outcome Domains for Trials in Autosomal Dominant Polycystic Kidney Disease: An International Delphi Survey.

Am J Kidney Dis 2020 Apr 28. Epub 2020 Apr 28.

Sydney School of Public Health, The University of Sydney, Sydney, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.

Rationale & Objective: Outcomes reported in trials involving patients with autosomal dominant polycystic kidney disease (ADPKD) are heterogeneous and rarely include patient-reported outcomes. We aimed to identify critically important consensus-based core outcome domains to be reported in trials in ADPKD.

Study Design: An international 2-round online Delphi survey was conducted in English, French, and Korean languages. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.01.005DOI Listing

Exome Sequencing and Identification of Phenocopies in Patients With Clinically Presumed Hereditary Nephropathies.

Am J Kidney Dis 2020 Apr 28. Epub 2020 Apr 28.

Institute of Human Genetics, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany. Electronic address:

Rationale & Objective: Hereditary nephropathies are clinically and genetically heterogeneous disorders. For some patients, the clinical phenotype corresponds to a specific hereditary disease but genetic testing reveals that the expected genotype is not present (phenocopy). The aim of this study was to evaluate the spectrum and frequency of phenocopies identified by using exome sequencing in a cohort of patients who were clinically suspected to have hereditary kidney disorders. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.12.008DOI Listing
April 2020
5.900 Impact Factor

Association of HLA Typing and Alloimmunity With Posttransplantation Membranous Nephropathy: A Multicenter Case Series.

Am J Kidney Dis 2020 Apr 28. Epub 2020 Apr 28.

Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY.

Rationale & Objectives: Posttransplantation membranous nephropathy (MN) represents a rare complication of kidney transplantation that can be classified as recurrent or de novo. The clinical, pathologic, and immunogenetic characteristics of posttransplantation MN and the differences between de novo and recurrent MN are not well understood.

Study Design: Multicenter case series. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.01.009DOI Listing
April 2020
5.900 Impact Factor

Association of Genetic Polymorphisms of TGF-β1, HMOX1, and APOL1 With CKD in Nigerian Patients With and Without HIV.

Am J Kidney Dis 2020 Apr 27. Epub 2020 Apr 27.

Kidney & Hypertension Research Unit, Department of Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

Rationale & Objective: Recent studies in the human immunodeficiency virus (HIV)-infected population have suggested that there are genetic predispositions to the development of chronic kidney disease (CKD) in this context. We investigated the association of genetic polymorphisms of the genes encoding apolipoprotein L1 (APOL1), transforming growth factor β1 (TGF-β1; a profibrotic cytokine), and heme oxygenase 1 (HMOX1) with prevalent CKD among adults with and without HIV infection.

Study Design: Case-control study. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.01.006DOI Listing
April 2020
5.900 Impact Factor

Kidney Histopathology and Prediction of Kidney Failure: A Retrospective Cohort Study.

Am J Kidney Dis 2020 Apr 23. Epub 2020 Apr 23.

Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN. Electronic address:

Rationale & Objective: The use of kidney histopathology for predicting kidney failure is not established. We hypothesized that the use of histopathologic features of kidney biopsy specimens would improve prediction of clinical outcomes made using demographic and clinical variables alone.

Study Design: Retrospective cohort study and development of a clinical prediction model. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.12.014DOI Listing

Pruritus as a Patient-Reported Primary Trial End Point in Hemodialysis: Evaluation and Implications.

Am J Kidney Dis 2020 Apr 22. Epub 2020 Apr 22.

Department of Medicine, Yale University, New Haven, CT. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2020.01.002DOI Listing

Risk of Cardiovascular Events and Mortality Among Elderly Patients With Reduced GFR Receiving Direct Oral Anticoagulants.

Am J Kidney Dis 2020 Apr 22. Epub 2020 Apr 22.

Dept. of Medicine, University of Ottawa, Ottawa, Canada; Institute for Clinical Evaluative Sciences, Ontario, Canada; Section of Nephrology, University of Ottawa, Ottawa, Canada. Electronic address:

Rationale & Objective: Evidence for efficacy of direct oral anticoagulants (DOACs) to prevent cardiovascular events and mortality in older individuals with a low estimated glomerular filtration rate (eGFR) is lacking. We sought to characterize the association of oral anticoagulant use with cardiovascular morbidity in elderly patients with or without reductions in eGFR, comparing DOACs to vitamin K antagonists (VKA).

Study Design: Population-based retrospective cohort study. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.02.446DOI Listing

Approach to Diagnosis and Management of Primary Glomerular Diseases Due to Podocytopathies in Adults: Core Curriculum 2020.

Am J Kidney Dis 2020 Jun 21;75(6):955-964. Epub 2020 Apr 21.

Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY. Electronic address:

Podocyte injury is the initiating step in the pathway toward clinically evident forms of nephrotic syndrome known as podocytopathies, represented as either minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS). There are hallmark differences in the histologic appearances of MCD and FSGS, which in turn represent distinct pathogenic models after initial podocyte injury (eg, no change in podocyte number in MCD vs podocyte detachment and death in FSGS). However, MCD and FSGS also share a number of common causes, supporting the theory that these diseases lie along a shared podocytopathy spectrum. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.12.019DOI Listing

Predictors of Intradialytic Symptoms: An Analysis of Data From the Hemodialysis Study.

Am J Kidney Dis 2020 Apr 21. Epub 2020 Apr 21.

Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.

Background: Most patients receiving maintenance hemodialysis (HD) experience adverse symptoms, which are associated with decreased quality of life. Despite decades of experience, our understanding of causes of HD symptoms remains limited. We aimed to identify modifiable patient- and HD-related predictors of intradialytic symptoms. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.01.004DOI Listing

Acute Kidney Injury With Massively Enlarged Noncystic Kidneys.

Am J Kidney Dis 2020 May 21;75(5):A15-A17. Epub 2020 Apr 21.

Department of Radiodiagnosis, Khyber Medical Institute, Nowpora, Srinagar, India.

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http://dx.doi.org/10.1053/j.ajkd.2019.10.020DOI Listing
May 2020
5.900 Impact Factor

A Web-Based Self-management Sodium Intervention in Individuals With CKD.

Am J Kidney Dis 2020 Jun 21;75(6):824-826. Epub 2020 Apr 21.

Department of Family Medicine and Public Health, University of California San Diego School of Medicine, San Diego, CA.

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http://dx.doi.org/10.1053/j.ajkd.2019.12.009DOI Listing

Association of Opioids and Nonsteroidal Anti-inflammatory Drugs With Outcomes in CKD: Findings From the CRIC (Chronic Renal Insufficiency Cohort) Study.

Am J Kidney Dis 2020 Apr 18. Epub 2020 Apr 18.

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD. Electronic address:

Rationale & Objective: Safe analgesic choices are limited in chronic kidney disease (CKD). We conducted a comparative analysis of harm from opioids versus nonsteroidal anti-inflammatory drugs (NSAIDs) in CKD.

Study Design: Prospective cohort study. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.12.010DOI Listing

HCV-Infected Deceased Donor Kidney Transplantation-Time to Take Up the Offer.

Am J Kidney Dis 2020 Jun 18;75(6):827-829. Epub 2020 Apr 18.

Harvard Medical School, Boston, MA; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1053/j.ajkd.2020.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247921PMC