11,424 results match your criteria American Journal Of Kidney Diseases[Journal]


Antimalarials in IgA Nephropathy: Did Our Supportive Therapy Armamentarium Just Increase?

Authors:
Jürgen Floege

Am J Kidney Dis 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology, Medizinische Klinik II, RWTH University Hospital Aachen, Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2019.02.022DOI Listing

Effects of Water Loading on Observed and Predicted Plasma Sodium, and Fluid and Urine Cation Excretion in Healthy Individuals.

Am J Kidney Dis 2019 Apr 17. Epub 2019 Apr 17.

Section of Nephrology, Department of Internal Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:

Rationale & Objective: The discovery of sodium storage without concurrent water retention suggests the presence of an additional compartment for sodium distribution in the body. The osmoregulatory role of this compartment under hypotonic conditions is not known.

Study Design: Experimental interventional study. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.02.021DOI Listing

Patient and Clinician Perspectives on Electronic Patient-Reported Outcome Measures in the Management of Advanced CKD: A Qualitative Study.

Am J Kidney Dis 2019 Apr 16. Epub 2019 Apr 16.

Centre for Patient Reported Outcomes Research; Institute of Applied Health Research, University of Birmingham, Edgbaston.

Rationale & Objective: Chronic kidney disease (CKD) can substantially affect patients' health-related quality of life. Electronic patient-reported outcome measures (ePROMs) may capture symptoms and health-related quality of life and assist in the management of CKD. This study explored patient and clinician views on the use of a renal ePROM system. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02726386193061
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http://dx.doi.org/10.1053/j.ajkd.2019.02.011DOI Listing
April 2019
3 Reads

APOL1 Genetic Testing in Living Kidney Transplant Donors.

Am J Kidney Dis 2019 Apr 11. Epub 2019 Apr 11.

Division of General Medical Sciences, Washington University School of Medicine, St. Louis, MO.

The presence of 2 apolipoprotein L1 gene (APOL1) risk variants is associated with increased risk for chronic kidney disease and end-stage kidney disease. Inferior allograft outcomes following transplantation with kidneys from donors with 2 risk variants have also been reported. These data, coupled with anecdotal case reports and a recent cohort study of living donors, raise important questions about the potential increased kidney disease risk for living donors with APOL1 risk variants and the need for testing as part of the standard living donor evaluation process. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.02.007DOI Listing

Person-Centered Care for Older Adults With Kidney Disease: Core Curriculum 2019.

Am J Kidney Dis 2019 Apr 11. Epub 2019 Apr 11.

Division of Nephrology, Department of Medicine, University of Washington and VA Puget Sound Health Care System, Seattle, WA.

This Core Curriculum article models a person-centered approach to care for older adults with kidney disease. We provide background information on the principles of person-centered care and outline ways in which this approach contrasts with the more disease-based approaches that dominate current medical education and practice. Using hypothetical cases, we discuss 3 clinical scenarios that arise commonly when caring for older adults with kidney disease: (1) a moderate reduction in estimated glomerular filtration rate, (2) new-onset nephrotic-range proteinuria, and (3) the prospect of starting dialysis. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.01.038DOI Listing
April 2019
1 Read
5.900 Impact Factor

Management of Kidney Transplant Recipients by General Nephrologists: Core Curriculum 2019.

Am J Kidney Dis 2019 Apr 10. Epub 2019 Apr 10.

University of California, San Francisco, CA. Electronic address:

Kidney transplantation is associated with improvement in quality of life and mortality as compared to remaining on dialysis. It is therefore the optimal treatment for kidney failure for most patients. While transplantation nephrologists typically care for the patient in the first 6 months posttransplantation, general nephrologists and internists often care for kidney transplant recipients after this period. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02726386193016
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http://dx.doi.org/10.1053/j.ajkd.2019.01.031DOI Listing
April 2019
2 Reads

Patient Perspectives on the Meaning and Impact of Fatigue in Hemodialysis: A Systematic Review and Thematic Analysis of Qualitative Studies.

Am J Kidney Dis 2019 Apr 5. Epub 2019 Apr 5.

Sydney School of Public Health, The University of Sydney, Sydney; Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, NSW, Australia. Electronic address:

Rationale & Objective: Fatigue is a highly prevalent and debilitating symptom in patients on hemodialysis therapy due to the uremic milieu, the hemodialysis treatment itself, and other comorbid conditions. However, fatigue remains underrecognized and the consequences are underappreciated because it may not be visible in clinical settings. This study aims to describe the experience that patients undergoing maintenance hemodialysis have with fatigue. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.01.034DOI Listing
April 2019
1 Read

Genetics of Nephrotic Syndrome Presenting in Childhood: Core Curriculum 2019.

Am J Kidney Dis 2019 Apr 4. Epub 2019 Apr 4.

Department of Pediatrics-Nephrology, 4 Center for Computational Medicine and Bioinformatics, University of Michigan School of Medicine, Ann Arbor, MI. Electronic address:

Nephrotic syndrome (NS) is one of the most challenging conditions to manage and treat, partly because we lack a specific molecular understanding of its pathogenesis and progression. This limits our ability to provide targeted therapy or precise prognostications. Fortunately, genomic discovery in NS and its translation to genomic-informed medicine is allowing us to improve our understanding of the molecular anatomy of NS and our ability to care for patients with NS. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.01.033DOI Listing
April 2019
4 Reads

Heavy Chain Fibrillary Glomerulonephritis: A Case Report.

Am J Kidney Dis 2019 Apr 4. Epub 2019 Apr 4.

Division of Hematology, Mayo Clinic, Rochester, MN.

Heavy chain amyloidosis and heavy chain deposition disease are the only known kidney diseases caused by the deposition of truncated immunoglobulin heavy chains. Fibrillary glomerulonephritis typically results from deposition of DNAJB9 (DnaJ heat shock protein family [Hsp40] member B9) and polytypic immunoglobulin G (IgG). We describe a patient with monoclonal gammopathy (IgG with λ light chain) who developed DNAJB9-negative fibrillary glomerulonephritis leading to end-stage kidney disease, with recurrence in 2 kidney allografts. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.01.032DOI Listing
April 2019
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The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery.

Am J Kidney Dis 2019 Apr 5. Epub 2019 Apr 5.

Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD. Electronic address:

Rationale & Objective: The process of angiogenesis after kidney injury may determine recovery and long-term outcomes. We evaluated the association of angiogenesis markers with acute kidney injury (AKI) and mortality after cardiac surgery.

Study Design: Prospective cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02726386193013
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http://dx.doi.org/10.1053/j.ajkd.2019.01.028DOI Listing
April 2019
3 Reads

When to Initiate Dialysis in Children and Adolescents: Is Waiting Worthwhile?

Am J Kidney Dis 2019 Apr 4. Epub 2019 Apr 4.

Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2019.02.008DOI Listing

Use of a Decision Aid for Patients Considering Peritoneal Dialysis and In-Center Hemodialysis: A Randomized Controlled Trial.

Am J Kidney Dis 2019 Apr 3. Epub 2019 Apr 3.

Vanderbilt University, Nashville, TN; Davita Clinical Research, Minneapolis, MN.

Rationale & Objective: Annually, about 100,000 US patients face the difficult choice between the most common dialysis types, in-center hemodialysis and peritoneal dialysis. This study evaluated the value of a new decision aid to assist in the choice of dialysis modality.

Study Design: A parallel-group randomized controlled trial to test the efficacy of the decision aid on decision-making outcomes. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.01.030DOI Listing
April 2019
1 Read

Paraneoplastic Cast Nephropathy Associated With Pancreatic Mixed Acinar-Neuroendocrine Carcinoma: A Case Report.

Am J Kidney Dis 2019 Apr 2. Epub 2019 Apr 2.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

Acute kidney injury is common in patients with cancer and may result from sepsis, obstruction, radiotherapy, chemotherapeutic agents, and nonsteroidal anti-inflammatory drugs. Rare reports of acute kidney injury due to cast nephropathy in patients with pancreatic acinar cell carcinoma have been described, but a pathogenetic link between cast nephropathy and carcinoma was not established. We report a patient with pancreatic mixed acinar-neuroendocrine carcinoma who developed severe acute kidney injury. Read More

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https://data.crossref.org/10.1053%2Fj.ajkd.2019.02.010
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http://dx.doi.org/10.1053/j.ajkd.2019.02.010DOI Listing
April 2019
5 Reads

Identifying Needs for Self-management Interventions for Adults With CKD and Their Caregivers: A Qualitative Study.

Am J Kidney Dis 2019 Apr 2. Epub 2019 Apr 2.

Departments of Medicine, University of Calgary; Community Health Sciences, University of Calgary; Interdisciplinary Chronic Disease Collaboration, Calgary, Alberta. Electronic address:

Rationale & Objective: Fostering the ability of patients to self-manage their chronic kidney disease (CKD), with support from caregivers and providers, may slow disease progression and improve health outcomes. However, little is known about such patients' needs for self-management interventions. We aimed to identify and describe the needs of adults with CKD and informal caregivers for CKD self-management support. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.02.006DOI Listing
April 2019
1 Read

A Delicate Balance: Intraglomerular Hemodynamics Across Ages in Type 1 Diabetes.

Am J Kidney Dis 2019 Apr 2. Epub 2019 Apr 2.

Division of Nephrology, Department of Medicine, Duke University School of Medicine; Renal Section, Durham VA Medical Center, Durham, NC. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2019.02.009DOI Listing

Serum Calcification Propensity and Coronary Artery Calcification Among Patients With CKD: The CRIC (Chronic Renal Insufficiency Cohort) Study.

Am J Kidney Dis 2019 Mar 29. Epub 2019 Mar 29.

Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address:

Rationale & Objective: Coronary artery calcification (CAC) is prevalent among patients with chronic kidney disease (CKD) and increases risks for cardiovascular disease events and mortality. We hypothesized that a novel serum measure of calcification propensity is associated with CAC among patients with CKD stages 2 to 4.

Study Design: Prospective cohort study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02726386193013
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http://dx.doi.org/10.1053/j.ajkd.2019.01.024DOI Listing
March 2019
8 Reads
5.900 Impact Factor

Allocation of the Highest Quality Kidneys and Transplant Outcomes Under the New Kidney Allocation System.

Am J Kidney Dis 2019 Mar 19. Epub 2019 Mar 19.

Division of Nephrology, Department of Medicine, Comprehensive Transplant Center, Cedars Sinai Medical Center, West Hollywood. Electronic address:

Rationale & Objective: Increased access to transplantation for highly sensitized candidates following implementation of the kidney allocation system (KAS) has been mostly due to higher use of organs with a lower kidney donor profile index (KDPI; a quality metric for donated kidneys), although changes in allocation of these organs was not intended. It is unclear whether clinical outcomes have changed in association with these changes. We investigated the use of kidneys with low and high KDPI scores over time and whether KDPI score affects patient and graft survival differently across varying levels of allosensitization. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.036DOI Listing
March 2019
2 Reads

Vision Impairment in CKD Patients: Epidemiology, Mechanisms, Differential Diagnoses, and Prevention.

Am J Kidney Dis 2019 Mar 28. Epub 2019 Mar 28.

Singapore Eye Research Institute, Singapore National Eye Centre; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School. Electronic address:

Eyes and kidneys have numerous structural, developmental, physiologic, and pathogenic pathways in common, suggesting that many kidney and eye diseases may be interlinked. Studies suggest that the prevalence of eye diseases and vision impairment are higher among persons with end-stage kidney disease and earlier stages of chronic kidney disease (CKD) than in those without. Ocular morbidity in persons with CKD and end-stage kidney disease may be due to the following risk factors: (1) underlying conditions and risk factors for CKD such as diabetes or hypertension, (2) metabolic disorders associated with CKD, (3) uremia and anemia, and (4) CKD treatment. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.047DOI Listing
March 2019
5 Reads
5.900 Impact Factor

C5 Convertase Blockade in Membranoproliferative Glomerulonephritis: A Single-Arm Clinical Trial.

Am J Kidney Dis 2019 Mar 28. Epub 2019 Mar 28.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS; L. Sacco Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. Electronic address:

Rationale & Objective: Primary membranoproliferative glomerulonephritis (MPGN) is a rare glomerulopathy characterized by complement dysregulation. MPGN progresses rapidly to kidney failure when it is associated with nephrotic syndrome. We assessed the effects of C5 convertase blockade in patients with MPGN and terminal complement activation. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.046DOI Listing
March 2019
1 Read

Paying for Frequent Dialysis.

Am J Kidney Dis 2019 Mar 25. Epub 2019 Mar 25.

Department of Health Management and Policy, University of Michigan School of Public Health; Division of Nephrology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI.

In late 2017, the 7 regional contractors responsible for paying dialysis claims in Medicare proposed new payment rules that would restrict payment for hemodialysis treatments in excess of 3 weekly to exceptional acute-care circumstances. Frequent hemodialysis is performed more frequently than the traditional thrice-weekly pattern, and many stakeholders-patients, providers, dialysis machine manufacturers, and others-have expressed concern that these payment rules will inhibit the growth of this treatment modality's use among US dialysis patients. In this Perspective, we explain the role of these contractors in the context of Medicare's in-center hemodialysis-centric dialysis payment system and assess how well this system accommodates the higher treatment frequencies of both peritoneal dialysis and frequent hemodialysis. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.01.027DOI Listing

Effects of Hydroxychloroquine on Proteinuria in IgA Nephropathy: A Randomized Controlled Trial.

Am J Kidney Dis 2019 Mar 25. Epub 2019 Mar 25.

Renal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China.

Rationale & Objective: Despite optimization of renin-angiotensin-aldosterone system (RAAS) inhibition, patients with immunoglobulin A nephropathy (IgAN) and persistent proteinuria remain at risk for kidney failure. We evaluated the efficacy and safety of hydroxychloroquine (HCQ), an immunomodulator, when added to the treatment regimen of patients with IgAN.

Study Design: Double-blind, randomized, placebo-controlled, phase 2 clinical trial. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.01.026DOI Listing
March 2019
1 Read

Predictors of Net Acid Excretion in the Chronic Renal Insufficiency Cohort (CRIC) Study.

Am J Kidney Dis 2019 Mar 22. Epub 2019 Mar 22.

Department of Medicine, Duke University School of Medicine, Durham, NC; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC. Electronic address:

Rationale & Objective: Higher urine net acid excretion (NAE) is associated with slower chronic kidney disease progression, particularly in patients with diabetes mellitus. To better understand potential mechanisms and assess modifiable components, we explored independent predictors of NAE in the CRIC (Chronic Renal Insufficiency Cohort) Study.

Study Design: Cross-sectional. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.043DOI Listing
March 2019
2 Reads

A Pivot Towards Moderating Intravenous Iron Therapy in Hemodialysis.

Am J Kidney Dis 2019 Mar 22. Epub 2019 Mar 22.

UNC Kidney Center & Division of Nephrology and Hypertension, Chapel Hill, NC. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2019.01.016DOI Listing
March 2019
1 Read

Probiotics and CKD Progression: Are Creatinine-Based Estimates of GFR Applicable?

Am J Kidney Dis 2019 Mar 22. Epub 2019 Mar 22.

Department of Medicine, College of Human Medicine, Michigan State University, Lansing, MI. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2019.02.003DOI Listing

Oxalosis Associated With High-Dose Vitamin C Ingestion in a Peritoneal Dialysis Patient.

Am J Kidney Dis 2019 Mar 22. Epub 2019 Mar 22.

Division of Nephrology and Hypertension; Mayo Clinic; The Rare Kidney Stone Consortium; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. Electronic address:

We report a case of systemic oxalosis involving the eyes and joints due to long-term use of high-dose vitamin C in a patient receiving maintenance peritoneal dialysis (PD). This 76-year-old woman with autosomal dominant polycystic kidney disease underwent living unrelated kidney transplantation 10 years earlier. The transplant failed 6 months before presentation, and she initiated hemodialysis therapy before transitioning to PD therapy 4 months later. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.01.022DOI Listing
March 2019
1 Read

Integrating Point-of-Care Ultrasonography Into Nephrology Fellowship Training: A Model Curriculum.

Am J Kidney Dis 2019 Mar 22. Epub 2019 Mar 22.

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, FL.

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http://dx.doi.org/10.1053/j.ajkd.2019.02.002DOI Listing
March 2019
1 Read

Nephrotic Syndrome and a Maculopapular Rash.

Am J Kidney Dis 2019 Apr;73(4):A13-A16

Department of Medicine, Reinier de Graaf Gasthuis, Delft, the Netherlands; Department of Nephrology, Reinier de Graaf Gasthuis, Delft, the Netherlands.

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http://dx.doi.org/10.1053/j.ajkd.2018.12.028DOI Listing
April 2019
2 Reads

KDOQI US Commentary on the 2017 ACC/AHA Hypertension Guideline.

Am J Kidney Dis 2019 Apr;73(4):437-458

Department of Medicine, University of Utah, Salt Lake City, UT.

Hypertension is a modifiable risk factor for cardiovascular morbidity and mortality and reduction of elevated blood pressure (BP) remains an important intervention for slowing kidney disease progression. Over the past decade, the most appropriate BP target for initiation and titration of BP-lowering medications has been an area of intense research and debate within the clinical community. In 2017, the American College of Cardiology and the American Heart Association (ACC/AHA) in conjunction with several other professional societies released new hypertension guidelines based on data from a systematic review of clinical trials and observational data. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02726386193003
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http://dx.doi.org/10.1053/j.ajkd.2019.01.007DOI Listing
April 2019
1 Read

Using Human Genetics to Drive Drug Discovery: A Perspective.

Authors:
Caroline S Fox

Am J Kidney Dis 2019 Mar 18. Epub 2019 Mar 18.

Merck & Co, Inc, Boston, MA. Electronic address:

The probability of success of developing medicines to treat human disease can be improved by leveraging human genetics. Different types of genetic data and techniques, including genome-wide association, whole-exome sequencing, and whole-genome sequencing, can be used to gain insight into human disease. Layering different types of genetic evidence from Mendelian disease, coding variants, and common variation can bolster support for a genetic target. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02726386193009
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http://dx.doi.org/10.1053/j.ajkd.2018.12.045DOI Listing
March 2019
12 Reads

Operationalizing Telehealth for Home Dialysis Patients in the United States.

Am J Kidney Dis 2019 Mar 18. Epub 2019 Mar 18.

Department of Emergency Medicine, George Washington University, Washington, DC.

Until January 2019, Medicare beneficiaries requiring maintenance dialysis therapy were eligible for telehealth services only if the originating site was located in a rural area and the patient was situated in an authorized facility. Free-standing dialysis facilities and the patient's home were clearly restricted sites. Beginning in 2019, new opportunities are available for home dialysis patients in the United States to engage in telehealth; these include existing waivers within End-Stage Renal Disease (ESRD) Seamless Care Organizations (ESCOs) participating in the Comprehensive ESRD Care demonstration project and, more broadly, for most prevalent home dialysis patients based on legislation within the 2018 Bipartisan Budget Act. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.01.023DOI Listing

Hypertension in CKD: Core Curriculum 2019.

Am J Kidney Dis 2019 Mar 19. Epub 2019 Mar 19.

Division of Nephrology and Hypertension, Department of Medicine, University of Maryland, Baltimore, MD.

Hypertension and chronic kidney disease (CKD) are closely interlinked pathophysiologic states, such that sustained hypertension can lead to worsening kidney function and progressive decline in kidney function can conversely lead to worsening blood pressure (BP) control. The pathophysiology of hypertension in CKD is complex and is a sequela of multiple factors, including reduced nephron mass, increased sodium retention and extracellular volume expansion, sympathetic nervous system overactivity, activation of hormones including the renin-angiotensin-aldosterone system, and endothelial dysfunction. Currently, the treatment target for patients with CKD is a clinic systolic BP < 130mm Hg. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.044DOI Listing
March 2019
2 Reads

Integrative Point-of-Care Ultrasound Curriculum to Impart Diagnostic Skills Relevant to Nephrology.

Am J Kidney Dis 2019 Mar 18. Epub 2019 Mar 18.

Department of Medicine, Johns Hopkins University; Department of Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2019.01.021DOI Listing

Cost-effectiveness of Pneumococcal Vaccination Among Patients With CKD in the United States.

Am J Kidney Dis 2019 Mar 19. Epub 2019 Mar 19.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Electronic address:

Rationale & Objective: Pneumococcal vaccine is recommended for adults 65 years and older and those younger than 65 years with clinical indications (eg, diabetes, lung/heart disease, kidney failure, and nephrotic syndrome). Its cost-effectiveness in less severe chronic kidney disease (CKD) is uncharacterized.

Study Design: Cost-effectiveness analysis. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.01.025DOI Listing
March 2019
1 Read

Identifying Important Outcomes for Young People With CKD and Their Caregivers: A Nominal Group Technique Study.

Am J Kidney Dis 2019 Mar 15. Epub 2019 Mar 15.

Sydney School of Public Health, The University of Sydney; Centre for Kidney Research, The Children's Hospital at Westmead, Sydney.

Rationale & Objective: Chronic kidney disease (CKD) has wide-ranging and long-term consequences for young people and their families. The omission of outcomes that are important to young people with CKD and their caregivers limits knowledge to guide shared decision making. We aimed to identify the outcomes that are important to young people with CKD and their caregivers. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.040DOI Listing
March 2019
2 Reads
5.900 Impact Factor

Ethical and Policy Considerations for Genomic Testing in Pediatric Research: The Path Toward Disclosing Individual Research Results.

Am J Kidney Dis 2019 Mar 14. Epub 2019 Mar 14.

Treuman Katz Center for Pediatric Bioethics, Seattle Children's Hospital and Research Institute, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA.

DNA is now commonly collected in clinical research either for immediate genomic analyses or stored for future studies. Many genomic studies were previously designed without awareness of the ethical issues that might arise regarding the disclosure of genomic test results. At the start of the Chronic Kidney Disease in Children (CKiD) Cohort Study in 2004, we did not foresee the advent of genomic technology or the associated ethical issues pertaining to genetic research in children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02726386193012
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http://dx.doi.org/10.1053/j.ajkd.2019.01.020DOI Listing
March 2019
3 Reads

Urinary Concentration Ability: Time to Bring the Tubules to the Table.

Am J Kidney Dis 2019 Mar 12. Epub 2019 Mar 12.

Kidney Research Institute, Division of Nephrology, University of Washington, Seattle, WA. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2019.01.019DOI Listing

CKD Progression: Teasing Out Contributions of Elements in the Human Exposome.

Authors:
Neil R Powe

Am J Kidney Dis 2019 Mar 12. Epub 2019 Mar 12.

Department of Medicine, Priscilla Chan and Mark Zuckerberg San Francisco General Hospital and University of California, San Francisco, San Francisco, CA. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2019.01.018DOI Listing

NUP Nephropathy: When Defective Pores Cause Leaky Glomeruli.

Am J Kidney Dis 2019 Mar 12. Epub 2019 Mar 12.

Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2019.01.015DOI Listing
March 2019
5.900 Impact Factor

Anti-LRP2 Nephropathy With Abundant IgG4-Positive Plasma Cells: A Case Report.

Am J Kidney Dis 2019 Mar 12. Epub 2019 Mar 12.

Department of Pathology, Oregon Health & Science University, Portland, OR. Electronic address:

In older adults, the most common kidney biopsy diagnoses include pauci-immune crescentic glomerulonephritis, membranous nephropathy, and focal segmental glomerulosclerosis. Recently, investigators described a small series of older patients (aged 66-80 years) with acute kidney injury and a kidney biopsy demonstrating tubular basement membrane (TBM) immune deposits of polytypic immunoglobulin G (IgG) and C3, acute tubular injury, and tubulointerstitial inflammation. They identified a circulating antibody against kidney tubular low-density lipoprotein (LDL) receptor-related protein 2 (LRP2; also known as megalin) in patients' sera and colocalization of LRP2 with IgG in TBM deposits. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.039DOI Listing
March 2019
1 Read
5.900 Impact Factor

An Ex Vivo Test of Complement Activation on Endothelium for Individualized Eculizumab Therapy in Hemolytic Uremic Syndrome.

Am J Kidney Dis 2019 Mar 6. Epub 2019 Mar 6.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Clinical Research Center for Rare Diseases Aldo e Cele Daccò and Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy; L. Sacco Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.

Rationale & Objective: Although primary atypical hemolytic uremic syndrome (aHUS) is associated with abnormalities in complement genes and antibodies to complement factor H, the role of complement in secondary aHUS remains debatable. We evaluated the usefulness of an ex vivo test to: (1) detect complement activation within the endothelium in primary and secondary aHUS, (2) differentiate active disease from remission, (3) monitor the effectiveness of eculizumab therapy, and (4) identify relapses during eculizumab dosage tapering and after discontinuation of treatment.

Study Design: Case series. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.11.012DOI Listing
March 2019
2 Reads

In Reply to 'TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD Is in Fact a Case of RVCL-S Presenting With Renal Features'.

Am J Kidney Dis 2019 Feb 27. Epub 2019 Feb 27.

Department of Internal Medicine, Division of Nephrology, Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1053/j.ajkd.2019.01.014DOI Listing
February 2019

Estimated GFR at Dialysis Initiation and Mortality in Children and Adolescents.

Am J Kidney Dis 2019 Mar 1. Epub 2019 Mar 1.

Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine, School of Medicine, Orange, CA. Electronic address:

Rationale & Objective: The association of estimated glomerular filtration rate (eGFR) at dialysis therapy initiation with mortality among adult dialysis patients has been greatly debated, with some studies showing no benefit from early dialysis therapy initiation. However, this association has not been well investigated in pediatric dialysis patients. The objective of this study was to evaluate the mortality risk associated with eGFR at dialysis therapy initiation in children and adolescents with kidney failure. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.038DOI Listing
March 2019
3 Reads
5.900 Impact Factor

Transcriptomics of Human Arteriovenous Fistula Failure: Genes Associated With Nonmaturation.

Am J Kidney Dis 2019 Feb 27. Epub 2019 Feb 27.

DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL. Electronic address:

Rationale & Objective: Improving arteriovenous fistula (AVF) outcomes requires better understanding of the biology underlying maturation or failure. Our current knowledge of maturation relies on extrapolation from other vascular pathologies, which does not incorporate unique aspects of AVF remodeling. This study compares the RNA expression of pre-access (native) veins and AVFs with distinct maturation outcomes. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.035DOI Listing
February 2019

Prevalence and Risk Factors for CKD Among Brickmaking Workers in La Paz Centro, Nicaragua.

Am J Kidney Dis 2019 Feb 27. Epub 2019 Feb 27.

Department of Environmental Health, Boston University School of Public Health, Boston, MA.

Rationale & Objective: In Central America, there is a high prevalence of chronic kidney disease (CKD) of nontraditional etiology often observed among agricultural workers. Few studies have assessed CKD prevalence among workers in nonagricultural occupations, which was the objective of this investigation.

Study Design: Prospective cohort study. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.01.017DOI Listing
February 2019

Comparing Seizure Risk Between Peritoneal Dialysis and Hemodialysis.

Am J Kidney Dis 2019 Feb 27. Epub 2019 Feb 27.

Universidade Nove de Julho, UNINOVE; Nephrology Division, Hospital das Clinicas HCFMUSP, Universidade de São Paulo.

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https://linkinghub.elsevier.com/retrieve/pii/S02726386193008
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http://dx.doi.org/10.1053/j.ajkd.2018.12.042DOI Listing
February 2019
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Mineralocorticoid Antagonism and Vascular Function in Early Autosomal Dominant Polycystic Kidney Disease: A Randomized Controlled Trial.

Am J Kidney Dis 2019 Feb 22. Epub 2019 Feb 22.

Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora.

Rationale & Objective: Vascular dysfunction, characterized by impaired vascular endothelial function and increased large-elastic artery stiffness, is evident early in autosomal dominant polycystic kidney disease (ADPKD) and is an important predictor of cardiovascular events and mortality. Aldosterone excess has been implicated in the development of endothelial dysfunction and arterial stiffness, in part by causing increased oxidative stress and inflammation. We hypothesized that aldosterone antagonism would reduce vascular dysfunction in patients with early-stage ADPKD. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.037DOI Listing
February 2019
2 Reads
5.900 Impact Factor