11,986 results match your criteria American Journal Of Kidney Diseases[Journal]


Elimination of Hepatitis C Virus in a Dialysis Population: A Collaborative Care Model in Taiwan.

Am J Kidney Dis 2021 Apr 30. Epub 2021 Apr 30.

Ministry of Health and Welfare, Taipei, Taiwan.

Rationale & Objective: Hemodialysis facilities are high-risk environments for hepatitis C virus (HCV). Eliminating HCV from all dialysis facilities in a community may be achieved more effectively under a collaborative care model.

Study Design: Quality improvement study of multidisciplinary collaborative care teams including nephrologists, gastroenterologists and public health practitioners. Read More

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Dialyzer Performance During Hemodialysis Without Systemic Anticoagulation Using a Heparin-Grafted Dialyzer Combined With a Citrate-Enriched Dialysate: Results of the Randomized Crossover Noninferiority EVOCIT Study.

Am J Kidney Dis 2021 Apr 30. Epub 2021 Apr 30.

Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Division of Nephrology and Hypertension.

Rationale And Objective: The EVOCIT study was designed to evaluate dialyzer performance during hemodialysis with and without systemic anticoagulation.

Study Design: Randomized, crossover, non-inferiority trial. Noninferiority was defined as a difference of ≤10% for the primary outcome. Read More

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We Won't Get Fooled Again: Finding the Who to Follow After Acute Kidney Injury.

Am J Kidney Dis 2021 Apr 27. Epub 2021 Apr 27.

Division of Nephrology, Kingston Health Sciences Center, Queen's University, Kingston, Ontario, Canada.

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Mortality, Kidney Failure, and Hospitalization Among Medicare Beneficiaries With CKD and Pulmonary Hypertension.

Am J Kidney Dis 2021 Apr 24. Epub 2021 Apr 24.

Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

Rationale And Objectives: Pulmonary hypertension (PH) is highly prevalent among patients with non-dialysis dependent CKD. We studied the associations of PH with mortality, kidney failure, as well as cardiovascular (CV) and non-CV hospitalization among Medicare beneficiaries diagnosed with CKD.

Setting: and Participants: Patients with PH (based on two claims within 2 years) and patients without PH matched on CKD stage from the Medicare 5% CKD sample (1996-2016). Read More

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A Practical Guide to Interpret Individual Participant Data Meta-analysis of Observational Studies.

Am J Kidney Dis 2021 Apr 23. Epub 2021 Apr 23.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Electronic address:

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Changes in GFR and Albuminuria in Routine Clinical Practice and the Risk of Kidney Disease Progression.

Am J Kidney Dis 2021 Apr 22. Epub 2021 Apr 22.

The George Institute for Global Health, University of New South Wales, Sydney, Australia; The George Institute for Global Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London UK; Department of Epidemiology, John Hopkins University, Baltimore, Maryland, USA.

Rationale And Objective: Changes in urinary albumin-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) have been used separately as alternative kidney disease outcomes in randomized trials. We tested the hypothesis that combined changes in UACR and eGFR predict advanced kidney disease better than either alone.

Study Design: Observational cohort study. Read More

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Hyperkalemia in a Patient With Leukemia.

Am J Kidney Dis 2021 05;77(5):A13-A14

Division of Nephrology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address:

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Patient Education for Kidney Failure Treatment: A Mixed-Methods Study.

Am J Kidney Dis 2021 Apr 21. Epub 2021 Apr 21.

Departments of Occupational Therapy and Community Health, Tufts University, Medford, MA; Research on Ethics, Aging, and Community Health (REACH Lab), Tufts University, Medford, MA. Electronic address:

Rationale & Objective: Education programs are needed for people with advanced chronic kidney disease (CKD) to understand kidney failure treatment options and participate in shared decision-making (SDM). Little is known about the content and accessibility of current education programs, and whether they support SDM.

Study Design: Stakeholder-engaged, mixed-methods design incorporating qualitative observations and interviews, and a quantitative content analysis of slide presentations. Read More

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Reducing Kidney Function Decline in Patients With CKD: Core Curriculum 2021.

Am J Kidney Dis 2021 Apr 21. Epub 2021 Apr 21.

Division of Nephrology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD.

An estimated 8% to 16% of the world's population has chronic kidney disease, defined by low glomerular filtration rate or albuminuria. Progression of chronic kidney disease is associated with adverse outcomes, including incident kidney failure with replacement therapy, accelerated cardiovascular disease, disability, and mortality. Therefore, slowing kidney function decline is paramount in the management of a patient with chronic kidney disease. Read More

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APOL1 and Preeclampsia: Intriguing Links, Uncertain Causality, Troubling Implications.

Am J Kidney Dis 2021 Apr 17. Epub 2021 Apr 17.

Glickman Urology and Kidney Institute, Case Western Reserve University, Cleveland, OH; Lerner Research Institute, Cleveland Clinic, Case Western Reserve University, Cleveland, OH; Departments of Molecular Medicine, Case Western Reserve University, Cleveland, OH.

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Oral Anticoagulant Agents in Patients With Atrial Fibrillation and CKD: A Systematic Review and Pairwise Network Meta-analysis.

Am J Kidney Dis 2021 Apr 16. Epub 2021 Apr 16.

Division of Nephrology, Beijing Anzhen Hospital, Capital Medical University, No. 2, Anzhen Road, Chaoyang District, Beijing, China. Electronic address:

Objective: To evaluate the relative efficacy and safety of different oral anticoagulant agents (OACs) for patients with atrial fibrillation (AF) and chronic kidney disease (CKD).

Study Design: Systematic review and pairwise and Bayesian network meta-analysis.

Setting & Study Populations: Adult patients with AF and CKD stages 3-5D who received OACs. Read More

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Recipient Obesity and Kidney Transplant Outcomes: A Mate-Kidney Analysis.

Am J Kidney Dis 2021 Apr 16. Epub 2021 Apr 16.

Section of Nephrology, Department of Medicine, University of Chicago, IL. Electronic address:

Rationale & Objective: The impact of extreme recipient obesity on long-term kidney transplant outcomes has been controversial. This study sought to evaluate the association of various levels of recipient obesity on kidney transplantation outcomes by comparing mate-kidney recipient pairs to address possible confounding effects of donor characteristics on post-transplant outcomes.

Design: Nationwide observational cohort study, using mate-kidney models. Read More

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Burden of Kidney Disease, Health-Related Quality of Life, and Employment Among Patients Receiving Peritoneal Dialysis and In-Center Hemodialysis: Findings From the DOPPS Program.

Am J Kidney Dis 2021 Apr 16. Epub 2021 Apr 16.

St. Michael's Hospital, University of Toronto, Toronto, ON, Canada. Electronic address:

Rationale & Objective: Individuals faced with decisions regarding kidney replacement therapy options need information on how dialysis treatments might affect daily activities and quality of life, and what factors might influence the evolution over time of the impact of dialysis on daily activities and quality of life.

Study Design: Observational cohort study.

Setting & Participants: 7,771 HD and PD participants from 6 countries participating in the Peritoneal and Dialysis Outcomes and Practice Patterns Studies (PDOPPS/DOPPS). Read More

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Collapsing Glomerulopathy as a Complication of Type I Interferon-Mediated Glomerulopathy in a Patient With RNASEH2B-Related Aicardi-Goutières Syndrome.

Am J Kidney Dis 2021 Apr 16. Epub 2021 Apr 16.

Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Firenze, Firenze;; Nephrology and Dialysis Unit, Meyer Children's Hospital, Firenze, Italy. Electronic address:

Aicardi-Goutières syndrome (AGS) is a well-characterised monogenic type I interferonopathy presenting with prominent neurological manifestations. Among extra-neurological features, renal involvement has only been described in one IFIH1-mutated patient who developed membranous nephropathy. The pathogenic role of augmented interferon signalling in tissues other than the central nervous system remains to be elucidated. Read More

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Risk of Symptomatic Kidney Stones During and After Pregnancy.

Am J Kidney Dis 2021 Apr 8. Epub 2021 Apr 8.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN. Electronic address:

Rationale & Objective: There are several well-known anatomical and physiological changes during pregnancy that could contribute to kidney stone formation, but evidence that they increase the risk of kidney stones during pregnancy is lacking. We determined whether there was an increased risk of a first-time symptomatic kidney stone during and after pregnancy.

Study Design: A population-based matched case-control study. Read More

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Biomarkers of Kidney Tubule Health, CKD Progression, and Acute Kidney Injury in SPRINT (Systolic Blood Pressure Intervention Trial) Participants.

Am J Kidney Dis 2021 Apr 12. Epub 2021 Apr 12.

Nephrology Section, Veterans Affairs San Diego Healthcare System, La Jolla, CA; Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA; Division of Preventive Medicine, Department of Family Medicine and Public Health, University of California San Diego, San Diego, CA. Electronic address:

Rationale & Objective: SPRINT compared the effect of intensive versus standard systolic blood pressure targets on cardiovascular morbidity and mortality. In this ancillary study, we evaluated the use of exploratory factor analysis (EFA) to combine biomarkers of kidney tubule health in urine and plasma and then study their role in longitudinal eGFR change and risk of acute kidney injury (AKI).

Study Design: Observational cohort nested in a clinical trial. Read More

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Accuracy of Peridialytic, Intradialytic, and Scheduled Interdialytic Recordings in Detecting Elevated Ambulatory Blood Pressure in Hemodialysis Patients.

Am J Kidney Dis 2021 Apr 12. Epub 2021 Apr 12.

Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Greece.

Rationale And Objective: Current recommendations suggest the use of ambulatory-BP-monitoring (ABPM) as the gold-standard for hypertension diagnosis and management in hemodialysis patients. This study assesses the accuracy of peridialytic, intradialytic, and scheduled interdialytic recordings in detecting abnormally elevated 44-h interdialytic BP.

Study Design: Diagnostic test study. Read More

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Arteriovenous Vascular Access-Related Procedural Burden Among Incident Hemodialysis Patients in the United States.

Am J Kidney Dis 2021 Apr 12. Epub 2021 Apr 12.

Arbor Research Collaborative for Health, Ann Arbor, Michigan.

Rationale & Objective: As the proportion of arteriovenous fistulae (AVF) compared to arteriovenous grafts (AVG) in the United States has increased, there has been a concurrent increase in interventions. We sought to explore AVF and AVG maturation and maintenance procedural burden in the first year of hemodialysis.

Study Design: Observational cohort study. Read More

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Sex Differences in Cardiovascular Outcomes in CKD: Findings From the CRIC Study.

Am J Kidney Dis 2021 Apr 12. Epub 2021 Apr 12.

Department of Medicine, University of Illinois at Chicago, Chicago, IL. Electronic address:

Rationale & Objective: Cardiovascular events are less common in women than men in general populations; however, studies in chronic kidney disease (CKD) are less conclusive. We evaluated sex-related differences in cardiovascular events and death in adults with CKD.

Study Design: Prospective cohort study. Read More

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Race and the Estimation of GFR: Getting It Right.

Am J Kidney Dis 2021 Apr 9. Epub 2021 Apr 9.

Journal of the American Society of Nephrology, Bernard, ME. Electronic address:

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Reassessing the Inclusion of Race in Diagnosing Kidney Diseases: An Interim Report From the NKF-ASN Task Force.

Am J Kidney Dis 2021 Apr 9. Epub 2021 Apr 9.

Department of Medicine, Priscilla Chan and Mark Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA. Electronic address:

For almost 2 decades, equations that use serum creatinine, age, sex, and race to estimate glomerular filtration rate (GFR) have included "race" as Black or non-Black. Given considerable evidence of disparities in health and health care delivery in African American communities, some regard keeping a race term in GFR equations as a practice that differentially influences access to care and kidney transplantation. Others assert that race captures important non-GFR determinants of serum creatinine and its removal from the calculation may perpetuate other disparities. Read More

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Urine Metabolite Levels, Adverse Kidney Outcomes, and Mortality in CKD Patients: A Metabolome-wide Association Study.

Am J Kidney Dis 2021 Apr 8. Epub 2021 Apr 8.

Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Hugstetter Str. 49, 79106 Freiburg, Germany. Electronic address:

Rationale & Objective: Mechanisms underlying the variable course of disease progression in patients with chronic kidney disease (CKD) are incompletely understood. The aim of this study was to identify novel biomarkers of adverse kidney outcomes and overall mortality, which may offer insights into pathophysiological mechanisms.

Study Design: Metabolome-wide association study. Read More

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Minimal Change Disease Following the Pfizer-BioNTech COVID-19 Vaccine.

Am J Kidney Dis 2021 Apr 8. Epub 2021 Apr 8.

Department of Nephrology and Hypertension, Barzilai University Medical Center, Ashkelon, Israel; Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheba, Israel. Electronic address:

We report on the development of minimal change disease (MCD) with nephrotic syndrome (NS) and acute kidney injury (AKI), shortly after first injection of the BNT162b2 COVID-19 vaccine (Pfizer-BioNTech). A 50-year-old previously healthy male was admitted to our hospital following the appearance of peripheral edema. Ten days earlier, he had received the first injection of the vaccine. Read More

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Clinical and Genetic Features of Autosomal Dominant Alport Syndrome: A Case Series.

Am J Kidney Dis 2021 Apr 1. Epub 2021 Apr 1.

Inherited Kidney Diseases, Nephrology Department, Fundació Puigvert, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Medicine Department-Universitat Autónoma de Barcelona, REDinREN, Instituto de Investigación Carlos III, Barcelona, Spain. Electronic address:

Rationale & Objective: Alport syndrome (AS) is a common genetic kidney disease accounting for approximately 2% of patients receiving kidney replacement therapy (KRT). It is caused by pathogenic variants in COL4A3, COL4A4 or COL4A5 genes. The aim of this study was to evaluate the clinical and genetic spectrum of patients with autosomal dominant Alport syndrome (ADAS). Read More

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One Step Closer to Developing a National Dialysis Registry in China.

Am J Kidney Dis 2021 Apr 1. Epub 2021 Apr 1.

Selzman Institute for Kidney Health and Section of Nephrology, Baylor College of Medicine, Houston, TX; Baker Institute for Public Policy, Rice University, Houston, TX. Electronic address:

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Effect of Bicarbonate on Net Acid Excretion, Blood Pressure, and Metabolism in Patients With and Without CKD: The Acid Base Compensation in CKD Study.

Am J Kidney Dis 2021 Mar 30. Epub 2021 Mar 30.

Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA. Electronic address:

Rationale & Objective: Patients with CKD are at elevated risk of metabolic acidosis due to impaired net acid excretion (NAE). Identifying early markers of acidosis may guide prevention in chronic kidney disease (CKD). This study compared NAE in participants with and without CKD, as well as the NAE, blood pressure (BP), and metabolomic response to bicarbonate supplementation. Read More

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Regional Citrate Anticoagulation for CKRT With Calcium-Containing Solutions: A Cohort Study.

Am J Kidney Dis 2021 Mar 30. Epub 2021 Mar 30.

Department of Medicine, University of California San Diego, San Diego, CA, USA.

Objective: Regional citrate anticoagulation (RCA) is the preferred anticoagulation method for continuous kidney replacement therapy (CKRT) recommended by the KDIGO guidelines. Limited availability of calcium-free solutions often imposes challenges to the implementation of RCA for CKRT (RCA-CKRT). The principal purpose of this study was to characterize the outcomes of RCA-CKRT using calcium-containing solutions. Read More

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