7,777 results match your criteria American Journal Of Hypertension[Journal]


Blood Pressure Variability Can Predict Carotid Sinus Reaction after Carotid Stenting.

Am J Hypertens 2022 May 21. Epub 2022 May 21.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Carotid stenting has become an important treatment for carotid disease. Carotid sinus reaction (CSR), a complication which is not uncommon and affects the outcome of carotid stenting. We investigated the predictors of CSR, including blood pressure variability and heart rate variability (BPV and HRV, respectively). Read More

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Antihypertensive drugs and cancer risk.

Am J Hypertens 2022 May 20. Epub 2022 May 20.

Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Hypertension is the most prevalent comorbidity in cancer patients. Consequently, many cancer patients are prescribed antihypertensive drugs before cancer diagnosis or during cancer treatment. However, whether antihypertensive drugs affect the incidence, treatment efficacy or prognosis of cancer remains unanswered. Read More

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Vulnerability to Hypertension is a Major Determinant of Racial Disparities in Alzheimer's Disease Risk.

Am J Hypertens 2022 May 17. Epub 2022 May 17.

Department of Surgery, Duke University School of Medicine, Duke University, Durham, NC.

Background: Higher incidence levels of Alzheimer's disease (AD) in Black Americans are well documented. However, quantitative explanations of this disparity in terms of risk-factor diseases acting through well-defined pathways is lacking.

Methods: We applied a Blinder-Oaxaca-based algorithm modified for censored data to a 5% random sample of Medicare beneficiaries age 65+ to explain Black/White disparities in AD risk in terms of differences in exposure and vulnerability to morbidity profiles based on 10 major AD-risk-related diseases. Read More

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Silencing of Fli1 gene mimics effects of preeclampsia and induces collagen synthesis in human umbilical arteries.

Am J Hypertens 2022 May 15. Epub 2022 May 15.

Padakonn Pharma, Narva, Estonia.

Rationale: Previously we demonstrated that in patients with preeclampsia elevated levels of endogenous Na/K-ATPase inhibitor, marinobufagenin, cause inhibition of Friend leukemia virus integration 1 (Fli1), a negative regulator of collagen-1 synthesis.

Objective: We hypothesized that in vitro silencing of Fli1 in healthy human umbilical arteries would be associated with an increase in collagen-1 output, similar to the effect of preeclampsia.

Methods: The isolated segments of healthy human umbilical arteries were tested for sensitivity to MBG and Fli1 silencing with Fli1 siRNA or control siRNA. Read More

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State-of-the-Art Review: Evidence on Red Meat Consumption and Hypertension Outcomes.

Am J Hypertens 2022 May 13. Epub 2022 May 13.

Department of Family Medicine, University of California, San Diego.

Hypertension (HTN) is a well-established risk factor for cardiovascular diseases (CVD), including ischemic heart disease, stroke, heart failure and atrial fibrillation. The prevalence of HTN, as well as mortality rates attributable to HTN, continue to increase, particularly in the United States and among Black populations. The risk of HTN involves a complex interaction of genetics and modifiable risk factors, including dietary patterns. Read More

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Kidney Health for All: Bridging the Gap in Kidney Health Education and Literacy.

Am J Hypertens 2022 May;35(5):470-477

International Federation of Kidney Foundations-World Kidney Alliance, The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.

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Low Diastolic Blood Pressure and Mortality in Older Women. Results from the Women's Health Initiative Long Life Study.

Am J Hypertens 2022 May 6. Epub 2022 May 6.

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.

Background: Recommended systolic blood pressure (SBP) targets often do not consider the relationship of low diastolic blood pressure (DBP) levels with cardiovascular disease (CVD) and all-cause mortality risk, which is especially relevant for older people with concurrent comorbidities.We examined the relationship of DBP levels to CVD and all-cause mortality in older women in the Women's Health Initiative Long Life Study (WHI-LLS).

Methods: The study sample included 7,875 women (mean age: 79 years) who underwent a BP measurement at an in-person home visit conducted in 2012-2013. Read More

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Effects of Renin-Angiotensin System Inhibitors on Mortality and Disease Severity of COVID-19 Patients: A Meta-analysis of Randomized Controlled Trials.

Am J Hypertens 2022 May;35(5):462-469

Department of Pharmacology, Henan University of Chinese Medicine, Henan, China.

Background: There is controversy over the effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) on the prognosis in patients with coronavirus disease 2019 (COVID-19), therefore, we aim to further explore the effect of renin-angiotensin-aldosterone system inhibitors on COVID-19-associated disease severity and mortality.

Methods: We systematically searched PubMed, Embase, Cochrane Library databases, medRxiv, and bioRxiv from inception to 6 September 2021. The primary outcome was all-cause mortality. Read More

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Blood pressure measurement - following a standardized protocol is what matters.

Authors:
Paul Muntner

Am J Hypertens 2022 May 5. Epub 2022 May 5.

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL.

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Home Blood Pressure Monitoring in Women of Child-bearing Age with Hypertension from 2009-2014.

Am J Hypertens 2022 May 4. Epub 2022 May 4.

Division of General Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts.

Background: Hypertension (HTN) is a leading cause of maternal mortality, and HTN guidelines recommend home blood pressure monitoring (HBPM) to help achieve blood pressure (BP) control. Evidence suggests that HBPM be coupled with a care team to maximize its effectiveness. HBPM use and the prevalence of provider counseling in child-bearing age women with HTN are unknown. Read More

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Medication Naïve Blood Pressure and Incident Cancers: Analysis of Two Nationwide Population-Based Databases.

Am J Hypertens 2022 May 4. Epub 2022 May 4.

The Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.

Background: Results of preceding studies on the relationship between blood pressure (BP) and cancers have been confounded due to individuals taking antihypertensive medications or shared risk factors. We assessed whether medication-naïve high BP is a risk factor for incident cancers.

Methods: This retrospective observational study included 1,388,331 individuals without a prior history of cancer and not taking antihypertensive medication enrolled in the JMDC Claims Database between 2005 and 2018. Read More

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Prevalence, Treatment, and Control of Hypertension Among US Women of Reproductive Age by Race/Hispanic Origin.

Am J Hypertens 2022 May 3. Epub 2022 May 3.

Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: To explore the prevalence, pharmacologic treatment, and control of hypertension among US non-pregnant women of reproductive age by race/Hispanic origin to identify potential gaps in care.

Methods: We pooled data from the 2011 to March 2020 (pre-pandemic) National Health and Nutrition Examination Survey cycles. Our analytic sample included 4,590 non-pregnant women aged 20-44 years who had at least one examiner-measured blood pressure (BP) value. Read More

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Increased Dephospho-uncarboxylated Matrix Gla-Protein Is Associated With Lower Axial Skeletal Muscle Mass in Patients With Hypertension.

Am J Hypertens 2022 May;35(5):393-396

Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Background: Matrix Gla-protein (MGP) is a well-established inhibitor of vascular calcification that is activated by vitamin K-dependent carboxylation. In the setting of vitamin K2 deficiency, dephospho-uncarboxylated MGP (dpucMGP) levels increase, and have been associated with large artery stiffening. Vitamin K2 is also a mitochondrial electron carrier in muscle, but the relationship of vitamin K2 deficiency and dpucMGP with muscle mass is not well understood. Read More

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Blockade of Microglial Activation in Hypothalamic Paraventricular Nucleus Improves High-salt Induced Hypertension.

Am J Hypertens 2022 Apr 19. Epub 2022 Apr 19.

Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, Xi'an 710061, China.

Background: It has been shown that activated microglia in brain releasing proinflammatory cytokines (PICs) contribute to the progression of cardiovascular diseases. In this study, we tested the hypothesis that microglial activation in paraventricular nucleus of hypothalamus (PVN), induced by high-salt diet, increases the oxidative stress via releasing PICs, and promotes sympathoexcitation and development of hypertension.

Methods: High-salt diet was given to male Dahl salt-sensitive rats to induce hypertension. Read More

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Ethnic Differences in The Prevalence of Hypertension in Colombia: Association with Education Level.

Am J Hypertens 2022 Apr 19. Epub 2022 Apr 19.

Population Health Research Institute, Hamilton, Canada.

Background: A higher prevalence of hypertension is reported among Afro-descendants compared to other ethnic groups in high-income countries, however there is a paucity of information in low- and medium-income countries.

Methods: We evaluated 3745 adults from 3 ethnic groups (552 White, 2,746 Mestizos, 447 Afro-descendants) enrolled in the prospective population-based cohort study (PURE) - Colombia. We assessed associations between anthropometric, socioeconomic, behavioral factors and hypertension. Read More

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A further step to classical semiology: The subtle expression of structural and functional cerebral changes in hypertension.

Am J Hypertens 2022 Apr 12. Epub 2022 Apr 12.

Hypertension and Vascular Risk Unit, Department of Internal Medicine, Institute of Medicine and Dermatology, Hospital Clínic (IDIBAPS), University of Barcelona, Spain.

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Clinical Practice Changes in Monitoring Hypertension early in the COVID-19 Pandemic.

Am J Hypertens 2022 Apr 11. Epub 2022 Apr 11.

Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, NE., Atlanta, Georgia.

Background: Clinical practices can use telemedicine and other strategies (e.g., self-measured blood pressure [SMBP]) for remote monitoring of hypertension to promote control while decreasing risk of exposure to SARS-CoV-2, the virus that causes COVID-19. Read More

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Thiazide and the Thiazide-Like Diuretics: Review of Hydrochlorothiazide, Chlorthalidone, and Indapamide.

Am J Hypertens 2022 Apr 11. Epub 2022 Apr 11.

Department of Pharmacy Practice and Science, College of Pharmacy,The University of Iowa. Iowa City, IA, USA.

The term thiazide is universally understood to refer to diuretics which exert their principal action in the distal tubule. The thiazide class is heterogenous, and can be further subdivided into compounds containing the benzothiadiazine ring structure - the thiazide-type (e.g. Read More

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Intensive Blood Pressure Treatment Goals: evidence for cardiovascular protection from observational studies and clinical trials.

Am J Hypertens 2022 Apr 7. Epub 2022 Apr 7.

Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

Epidemiologic studies have consistently identified a strong, progressive relationship between blood pressure and cardiovascular disease events, in a range of systolic blood pressure (SBP) from as low as 90 mm Hg to as high as 180 mm Hg. Clinical trials have demonstrated greater prevention of cardiovascular disease with more compared to less intensive antihypertensive drug treatment. Meta-analyses of randomized controlled trials provides strong evidence for more intensive antihypertensive drug therapy down to an SBP of 130 mm Hg, and to an SBP 120-124 mm Hg in the meta-analysis with the greatest statistical power. Read More

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Blood pressure control among non-Hispanic Black adults is lower than non-Hispanic White adults despite similar treatment with anti-hypertensive medication: NHANES 2013-2018.

Am J Hypertens 2022 Apr 5. Epub 2022 Apr 5.

Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention.

Background: Controlled blood pressure can prevent or reduce adverse health outcomes. Social and structural determinants may contribute to the disparity that despite equivalent proportions on anti-hypertensive medication, non-Hispanic Black (Black) adults have lower blood pressure control and more cardiovascular events than non-Hispanic White (White) adults.

Methods: Data from 2013-2018 National Health and Nutrition Examination Survey were pooled to assess control among Black and White adults by anti-hypertensive medication use and selected characteristics using the 2017 American College of Cardiology/American Heart Association (ACC/AHA) Blood Pressure Guideline definition (systolic blood pressure <130 mm Hg and diastolic blood pressure <80 mm Hg) among 4,739 adults. Read More

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Apparent Treatment-Resistant Hypertension Among Stroke Survivors: A Transcontinental Study assessing impact of race and geography.

Am J Hypertens 2022 Apr 2. Epub 2022 Apr 2.

University of Florida, Gainesville, USA.

Background: Race and geographic differences in the prevalence and predictors of hypertension in stroke survivors have been reported, but apparent treatment-resistant hypertension (aTRH) among stroke survivors by race (African ancestry vs Non-Hispanic Caucasians) and by geography (continental Africa versus the United States) are under studied.

Methods: This is a cross-sectional study using ethically approved stroke registries from the University of Florida and the Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Univariate and multivariate regression was used to evaluate for differences in prevalence of aTRH and associations with clinical covariates. Read More

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Higher pulse pressure is associated with increased risk of cardio-cerebrovascular disease and all-cause mortality: A Korean national cohort study.

Am J Hypertens 2022 Apr 1. Epub 2022 Apr 1.

Department of Family Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.

Background: This study aimed to investigate the association of pulse pressure (PP) with the cardio-cerebrovascular disease (CCVD) risk and all-cause mortality according to blood pressure level using Korean national cohort data.

Methods: This study was retrospectively designed and based on the Korean National Health Insurance Service-National Health Screening Cohort. Participants aged 40 to 69 years at baseline were categorized into normal, elevated, stage 1, and stage 2 groups according to blood pressure. Read More

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Risk of chronic kidney disease associated with orthostatic hypotensive stress: A community-based Korean study.

Am J Hypertens 2022 Mar 30. Epub 2022 Mar 30.

Department of Internal Medicine, Uijeongbu Eulji University Medical Center, Gyeonggi-do, Korea.

Background: The relationship between orthostatic blood pressure (BP) changes and incident chronic kidney disease (CKD) has not been explored in Asian populations.

Methods: We reviewed the data of 7,039 participants from the Ansung-Ansan cohort study. BP was measured in the supine position and 2 min after standing. Read More

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Differences in hypertension and stage II hypertension by demographic and risk factors, obtained by two different protocols in US adults: National Health and Nutrition Examination Survey, 2017-2018.

Am J Hypertens 2022 Mar 25. Epub 2022 Mar 25.

Division of Health and Nutrition Examination Surveys National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland.

Objective: To compare prevalence of hypertension and stage II hypertension assessed by two blood pressure observation protocols.

Methods: Participants aged 18 years and older (n = 4,689) in the National Health and Nutrition Examination Survey (NHANES 2017-2018) had their blood pressure (BP) measured following two protocols: the legacy auscultation protocol [AP] and oscillometric protocol [OP]. The order of protocols was randomly assigned. Read More

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Full Association of cerebral oxygenation during exercise with target organ damage in middle-aged hypertensive and normotensive individuals.

Am J Hypertens 2022 Mar 24. Epub 2022 Mar 24.

Exercise Physiology and Biochemistry Laboratory, Department of Sports Science at Serres, Agios Ioannis, Aristotle University of Thessaloniki, Greece.

Background: The brain is one of the main target organs affected by hypertension. Impaired cerebral oxygenation during exercise is an indicator of cerebral dysfunction. We aimed to investigate whether cerebral oxygenation during exercise correlates with subclinical markers of early target organ damage in a population of middle-aged, newly diagnosed hypertensive and healthy individuals. Read More

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Blood pressure goals in acute stroke.

Am J Hypertens 2022 Mar 22. Epub 2022 Mar 22.

Department of Cardiovascular Medicine, State Key Laboratory of Medical Geonomics, Shanghai Key Laboratory of Hypertension, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, National Research Centre for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Antihypertensive treatment is highly effective in both primary and secondary prevention of stroke. However, current guideline recommendations on the blood pressure goals in acute stroke are clinically empirical and generally conservative. Antihypertensive treatment is only recommended for severe hypertension. Read More

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Impact of asleep and 24-hour blood pressure data on the prevalence of masked hypertension by race/ethnicity.

Am J Hypertens 2022 Mar 18. Epub 2022 Mar 18.

Epidemiology and Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Background: We pooled ambulatory blood pressure monitoring data from five US studies, including the Jackson Heart Study (JHS), the Coronary Artery Risk Development in Young Adults (CARDIA) study, the Masked Hypertension Study, the Improving the Detection of Hypertension Study, and the North Carolina Masked Hypertension Study. Using a cross-sectional study design, we estimated differences in the prevalence of masked hypertension by race/ethnicity when out-of-office BP included awake, asleep, and 24-hour BP versus awake BP alone.

Methods: We restricted the analyses to participants with office systolic BP (SBP) < 130 mmHg and diastolic BP (DBP) < 80 mmHg. Read More

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Beta-Blockers for Treatment of Hypertension; Where Do They Fit?

Am J Hypertens 2022 Mar 18. Epub 2022 Mar 18.

Division of Nephrology and Hypertension, Mayo Clinic Arizona, Scottsdale, AZ.

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How Do We Jump-Start Self-measured Blood Pressure Monitoring in the United States? Addressing Barriers Beyond the Published Literature.

Am J Hypertens 2022 03;35(3):244-255

Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Hypertension is highly prevalent in the United States, and many persons with hypertension do not have controlled blood pressure. Self-measured blood pressure monitoring (SMBP), when combined with clinical support, is an evidence-based strategy for lowering blood pressure and improving control in persons with hypertension. For years, there has been support for widespread implementation of SMBP by national organizations and the federal government, and SMBP was highlighted as a primary intervention in the 2020 Surgeon General's Call to Action to Control Hypertension, yet optimal SMBP use remains low. Read More

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