5,822 results match your criteria American Journal Of Dermatopathology[Journal]


Unusual Presentations of Primary and Metastatic Adenoid Cystic Carcinoma Involving the Skin.

Am J Dermatopathol 2020 Jun 30. Epub 2020 Jun 30.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Adenoid cystic carcinoma (ACC) is most commonly seen in the salivary glands but may occur at other sites. Primary or metastatic involvement of the skin is unusual. We report 2 cases of ACC with unusual presentation. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001730DOI Listing

False-Negative Rate of Direct Immunofluorescence on Lower Extremities in Bullous Pemphigoid.

Am J Dermatopathol 2020 Jun 30. Epub 2020 Jun 30.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC.

Bullous pemphigoid (BP) is the most common autoimmune blistering disorder of the skin. It is typified by tense blisters with a subepidermal split and mixed dermal inflammatory infiltrate on histology. Biopsy of the perilesional skin for direct immunofluorescence (DIF) has become the gold standard in the diagnosis of BP. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001710DOI Listing

Psoriasis With Eczematous Features: A Retrospective Clinicopathologic Study.

Am J Dermatopathol 2020 Jun 30. Epub 2020 Jun 30.

The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, NY.

Background: Dermatopathologists sometimes encounter patients with features of psoriasis vulgaris and additional changes of eczematous dermatoses. These cases are challenging to diagnose, and the clinical implications are unclear. In the age of targeted therapy, it is important to improve our understanding of these findings so that patients are managed appropriately. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001711DOI Listing

Folliculocystic and Collagen Hamartoma: A Distinct Hamartoma Associated With Tuberous Sclerosis Complex.

Am J Dermatopathol 2020 Jun 30. Epub 2020 Jun 30.

Department of Dermatology, University of Puerto Rico School of Medicine, San Juan, PR.

Tuberous sclerosis complex (TSC) is a neurocutaneous disease characterized by cutaneous and extracutaneous hamartomas. Dermatologic evaluation is critical for early diagnosis because mucocutaneous manifestations account for 4 of 11 major and 3 of 6 minor diagnostic criteria. Folliculocystic and collagen hamartoma (FCCH) is a recently described entity associated with TSC. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001720DOI Listing

Coronavirus (COVID-19) Infection-Induced Chilblains: A Brisk Perieccrine Inflammatory Response.

Am J Dermatopathol 2020 Jun 30. Epub 2020 Jun 30.

American Dermatopathology Laboratory, Centerville, OH.

The varying cutaneous and pathological manifestations of coronavirus 2 (SARS-CoV-2 or COVID-19) may have prognostic implications. Acral ischemic findings present with a hypercoagulable state in critically ill COVID-19 patients. Pathologically confirmed varicella-like exanthem and perniosis COVID-19 cases have correlated with paucisymptomatic and asymptomatic patients in previous reports. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001733DOI Listing

Intravascular Cutaneous Disorders. A Clinicopathologic Review.

Am J Dermatopathol 2020 Jun 30. Epub 2020 Jun 30.

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

Intravascular proliferations of the skin are clinically heterogeneous and may present with a wide range of clinical features, including violaceous papules, nodules, plaques, or other unspecific cutaneous lesions. Histopathologically, these conditions are characterized by proliferation of different cell types within the lumina of dermal vessels and endothelial cell hyperplasia. Immunohistochemistry is the best tool to identify the nature of the intravascular proliferating cells and the type of involved vessel. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001706DOI Listing

Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema.

Am J Dermatopathol 2020 Jun 30. Epub 2020 Jun 30.

Department of Dermatology, University Clinic Münster, Münster, Germany.

Introduction: Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is a clinically very well-defined drug eruption, but the histopathological findings are still considered to be nonspecific.

Objectives: To characterize the histopathological and immunophenotypical features of SDRIFE.

Material And Methods: We performed a retrospective study that identified 11 biopsies from 9 patients with SDRIFE. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001722DOI Listing

Lipofibromatosis-Like Neural Tumor: A Case Report and Review of the Literature.

Am J Dermatopathol 2020 Jun 30. Epub 2020 Jun 30.

Hospices Civils de Lyon, Hôpital Lyon Sud, Service d'anatomie et de cytologie pathologiques, Pierre Bénite, France.

Lipofibromatosis-like neural tumors (LPF-NT) are soft tissue tumors characterized by a lipofibromatosis-like pattern, CD34/PS100 positivity, and recurrent NTRK1 gene rearrangement. It occurs mainly in pediatric patients or young adults. We report here, the first case of LPF-NT in a middle-aged adult initially misdiagnosed as a myoepithelial tumor. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001734DOI Listing

An 80-Year-Old Man With Erythematous Papulonodular Plaque on the Mons Pubis: Challenge.

Am J Dermatopathol 2020 Jul;42(7):e105

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY.

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http://dx.doi.org/10.1097/DAD.0000000000001435DOI Listing

A Slow-Growing Mass on a Back of a Healthy Woman: Challenge.

Am J Dermatopathol 2020 Jul;42(7):e103-e104

Department of Dermatology, Hospital General Universitario de Valencia, Valencia, Spain.

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http://dx.doi.org/10.1097/DAD.0000000000001428DOI Listing

An 80-Year-Old Man With Erythematous Papulonodular Plaque on the Mons Pubis: Answer.

Am J Dermatopathol 2020 Jul;42(7):549-550

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY.

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http://dx.doi.org/10.1097/DAD.0000000000001436DOI Listing

A Slow-Growing Mass on a Back of a Healthy Woman: Answer.

Am J Dermatopathol 2020 Jul;42(7):548

Department of Dermatology, Hospital General Universitario de Valencia, Valencia, Spain.

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http://dx.doi.org/10.1097/DAD.0000000000001427DOI Listing

A Man With New Subcutaneous Nodules: Answer.

Am J Dermatopathol 2020 Jul;42(7):547

Department of Dermatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL.

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http://dx.doi.org/10.1097/DAD.0000000000001417DOI Listing

Diagnosing Calciphylaxis: A Review With Emphasis on Histopathology.

Am J Dermatopathol 2020 Jul;42(7):471-480

Assistant Professor, Departments of Pathology and Dermatology, University of California, San Francisco, CA.

Calciphylaxis is a cutaneous vasculopathy with high morbidity and mortality characterized by vascular intimal fibrosis, calcification, stenosis, thrombosis, and eventual tissue death due to ischemia. Histopathologic diagnosis is often difficult, frequently necessitating multiple tissues samples due to lack of specific histopathologic features and subtle changes on biopsies of early lesions. In this study, we review the reported clinical and histopathologic features of calciphylaxis, correlating them with relevant imaging, ancillary studies, and pathophysiology. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001526DOI Listing

Histopathological Study of a Broad Spectrum of Skin Dermatoses in Patients Affected or Highly Suspected of Infection by COVID-19 in the Northern Part of Italy: Analysis of the Many Faces of the Viral-Induced Skin Diseases in Previous and New Reported Cases.

Am J Dermatopathol 2020 Jun 10. Epub 2020 Jun 10.

Division of Pathology, Università degli Studi di Milano, Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

Skin manifestations of COVID-19 infections are diverse and are new to the dermatology community. We had the opportunity to examine the clinical and histopathological features of several patients who were divided into 3 groups. The first group included 8 COVID-19-positive patients who were hospitalized and quarantined at home. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001707DOI Listing

Lymphomatoid Papulosis With a Unique T Follicular Helper-Like Phenotype.

Am J Dermatopathol 2020 Jun 5. Epub 2020 Jun 5.

Department of Pathology, Dermatopathology Section, The University of Texas MD Anderson Cancer Center, Houston, TX.

Lymphomatoid papulosis (LyP) is a benign skin condition that typically presents with grouped or scattered lesions on the body that self-resolve within weeks or months of onset. LyP belongs to the group of CD30-positive lymphoproliferative disorders. Several histological variants of LyP exist, and the histological features of LyP can overlap with other lymphoproliferative disorders; therefore, both histological and clinical correlations are needed for a proper diagnosis of LyP. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001693DOI Listing

Metastatic Prostatic Adenocarcinoma in Patient With Muir-Torre Syndrome Misdiagnosed as Metastatic Sebaceous Carcinoma: Case Report and Systematic Literature Review.

Am J Dermatopathol 2020 Jun 5. Epub 2020 Jun 5.

Department of Pathology, McGill University Health Centre, Montreal, Québec, Canada.

Muir-Torre syndrome (MTS) is a rare autosomal dominant condition characterized by the presence of at least one cutaneous sebaceous tumor and one visceral malignancy, arising mostly from the gastrointestinal tract. We present the case of a 63-year-old man with several cutaneous and visceral neoplasias in the context of MTS, and a pelvic lymph node lesion diagnosed initially as metastatic sebaceous carcinoma, but later identified as metastasis from a newly diagnosed prostatic adenocarcinoma. Histological similarities between these 2 lesions are discussed. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001633DOI Listing

An Unusual Histopathological Presentation of Epidermotropic Metastatic Pharyngeal Squamous Cell Carcinoma.

Am J Dermatopathol 2020 Jun 5. Epub 2020 Jun 5.

Departments of Pathology, and.

Epidermotropic metastasis of head and neck squamous cell carcinoma is rare. We report a case of a 56-year-old white man with a history of oral squamous cell carcinoma who presented with multiple papules on the face, eyelid, and chest wall. The histopathologic examination of the skin lesions revealed nests of malignant cells with basaloid features and zones of cytoplasmic vacuolization predominantly within the dermis but focally involving the epidermis. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001688DOI Listing

Rosai-Dorfman Disease-Like Reaction to Tattoo.

Am J Dermatopathol 2020 Jun 5. Epub 2020 Jun 5.

Department of Pathology, Los Angeles Medical Center, Southern California Kaiser Permanente, Los Angeles, CA.

A 47-year-old white man presented with a 14-month history of an asymptomatic 2-cm, slow-growing nodular lesion on his left shin that arose in the background of a black tattoo. An excisional biopsy followed by histological examination revealed a prominent lymphohistiocytic infiltrate, with many large, foamy histiocytic cells containing intact inflammatory cells within their cytoplasm, findings consistent with emperipolesis, a feature typical of Rosai-Dorfman disease (RDD). By immunohistochemistry, S-100 (a marker that is positive in almost all cases of RDD) was negative, arguing against the diagnosis of RDD. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001616DOI Listing

Neonatal Autoimmune Subepidermal IgG/IgA Blistering Disease With Severe Laryngeal and Esophageal Involvement: A Report of a Case and Review of the Literature.

Am J Dermatopathol 2020 Jun 15. Epub 2020 Jun 15.

Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.

Neonatal autoimmune subepidermal blistering disease is rare. Mucosal involvement is more common in neonatal linear immunoglobulin A (IgA) bullous dermatosis. We describe a neonate with subepidermal cutaneous blistering disease with severe laryngeal and esophageal involvement leading to acute respiratory distress. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001700DOI Listing

Acquired Epidermodysplasia Verruciformis in the Setting of Renal Transplant.

Am J Dermatopathol 2020 Jun 15. Epub 2020 Jun 15.

Trillium Creek Dermatology and Surgery Center, Medina, OH.

Epidermodysplasia verruciformis (EV) is a rare dermatologic condition that is clinically characterized by flat, cutaneous, verrucous papules, pityriasis versicolor-like lesions, and similar lichenoid papules. There are 2 forms of EV: a classic inherited genodermatosis and a secondary acquired form. EV predisposes individuals to infections with certain types of human papillomavirus virus and subsequently increases the risk of cutaneous squamous cell carcinoma. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001696DOI Listing

Indeterminate Dendritic Cell Tumor as Cutaneous Involvement of Chronic Myelomonocytic Leukemia Successfully Treated With Phototherapy.

Am J Dermatopathol 2020 Jun 15. Epub 2020 Jun 15.

Service Dermatology, Complejo Asistencial de Palencia, Palencia, Spain.

Indeterminate dendritic cell tumor (IDCT) is a rare disease composed of so-called indeterminate cells, a dendritic cell subset displaying histological and some ultrastructural and immunophenotypic features of Langerhans cells, but lacking Birbeck granules. We report a case of cutaneous IDCT occurring in a patient with chronic myelomonocytic leukemia (CMML) successfully treated with UV-A phototherapy. Next-generation sequencing studies of the CMML demonstrated mutations in TET2, ASXL1, and ZRS2 genes, also detected in the IDCT, demonstrating a clonal relationship between both tumors and confirming IDCT as a specific subtype in the spectrum of CMML-related cutaneous lesions. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001703DOI Listing

A Case of Multiple Tiny Osteolipomas on Face.

Am J Dermatopathol 2020 Jun 15. Epub 2020 Jun 15.

Department of Dermatology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea.

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http://dx.doi.org/10.1097/DAD.0000000000001680DOI Listing

Twenty-Eight Cases of Extraocular Sebaceous Carcinoma: A Correlative Clinicopathological and Immunohistochemical Analysis of Extraocular Sebaceous Carcinomas and Benign Sebaceous Gland Tumors.

Am J Dermatopathol 2020 Jun 15. Epub 2020 Jun 15.

Gerhard-Domagk-Institute of Pathology, University of Muenster, Münster, Germany.

Extraocular sebaceous carcinoma (ESC) is a rare appendiceal skin tumor. In contrast to ocular sebaceous carcinoma, information about the exact cellular architecture of these lesions is scarce and the histogenesis of ESC is unknown. Here, we extend our previous study and investigate 28 extraocular carcinomas in comparison to 54 benign sebaceous tumors and 8 cases of normal sebaceous glands using a broad spectrum of antibodies against p63, several keratins, adipophilin, EMA, Ki67, androgen receptor, and mismatch repair proteins. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001667DOI Listing

Combination of Congenital and Deep Penetrating Nevus by Acquisition of β-Catenin Activation.

Am J Dermatopathol 2020 Jun 17. Epub 2020 Jun 17.

Department of Dermatology, Fundación Jimenez-Diaz, Madrid, Spain.

Deep penetrating nevus (DPN) is an intradermal, sometimes compound benign melanocytic lesion, which involves the reticular dermis, occasionally reaching the subcutis, which can raise concern for melanoma both clinically and histologically. Recently, it has been genetically defined by the combination of MAPK activating and β-catenin activating mutations. We sought to investigate genetic alterations in 2 cases of combined nevi of congenital melanocytic and DPN. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001704DOI Listing

A Case Report of Papillary Digital Adenocarcinoma With BRAFV600E Mutation and Quantified Mutational Burden.

Am J Dermatopathol 2020 Jun 17. Epub 2020 Jun 17.

Medicine.

Papillary digital adenocarcinoma (PDA) is a rare eccrine tumor that is most often found on the digits. Few case reports have described PDAs located on atypical sites. It is now accepted that PDAs cannot be distinguished from benign adenomas based on histological features, and it is recommended to excise all of these lesions. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001694DOI Listing

Apocrine Chromhidrosis.

Am J Dermatopathol 2020 Jun 17. Epub 2020 Jun 17.

Dermatology Department, Basildon and Thurrock University Hospital, Basildon, Essex, United Kingdom.

Apocrine chromhidrosis is a rare diagnosis that occurs due to colored sweat being secreted from the apocrine glands, which are located in the axillae, anogenital skin, and areolae and over the skin of the trunk, face, and scalp. We present the case of a 65-year-old woman who presented with a sudden onset of pink sweating affecting mainly her axillae but also her pelvis, causing staining of clothing and bed sheets. There was nil to note on examination and histology with immunostaining demonstrated focally prominent yellow-brown lipofuscin granules in the cytoplasm of the apocrine secretory cells confirming the diagnosis. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001712DOI Listing
June 2020
1.426 Impact Factor

A New Digital Method for Counting Mast Cells in Cutaneous Specific Lesions of Mastocytosis: A Series of Adult Cases of Mastocytosis With Clinical-Pathological Correlations.

Am J Dermatopathol 2020 Jun 17. Epub 2020 Jun 17.

Service d'Anatomie et Cytologie Pathologiques, Hôpital Necker-Enfants Malades, APHP, Paris, France.

Cutaneous mastocytosis is characterized by the abnormal accumulation of mast cells in the skin. However, mast cell counting is not always easy and reproducible with classical methods. This work aims to demonstrate the reliability, usability, and virtues of a new software used on digital tablets for counting mast cells in cutaneous specific lesions of mastocytosis, to assess differences in mast cell counts between clinical subtypes of mastocytosis in the skin, and to consider the feasibility of applying a diagnostic mast cell count cutoff to urticaria pigmentosa, which is the most frequent form of cutaneous mastocytosis. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001705DOI Listing

Generalized Progressive Papulonodular Skin Lesions in a 37-Year-Old Man: Challenge.

Am J Dermatopathol 2020 Jun 4. Epub 2020 Jun 4.

Department of Laboratory Medicine & Pathology, Hamad Medical Corporation, Doha, Qatar.

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http://dx.doi.org/10.1097/DAD.0000000000001610DOI Listing

Focal Dermal Elastosis: A Proposed Update to the Nomenclature.

Am J Dermatopathol 2020 May 28. Epub 2020 May 28.

The Robert Larner, M.D. College of Medicine at the University of Vermont, Burlington, VT.

Late-onset focal dermal elastosis is a clinical mimic of pseudoxanthoma elasticum that lacks associations with systemic disease. Although initial reports asserted that the disorder occurs only in the elderly, a growing body of case reports document cases in patients as young as 39 years. We present a case of a 59-year-old woman with this disorder. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001683DOI Listing

Flame Figures in Linear Immunoglobulin A Bullous Dermatosis Secondary to Parvovirus B19 Infection.

Am J Dermatopathol 2020 May 28. Epub 2020 May 28.

Departments of Dermatology, and.

Flame figures represent a characteristic but nondiagnostic histological finding in eosinophilic dermatoses. Some bullous autoimmune diseases with a predominant eosinophilic infiltrate, such as bullous pemphigoid, pemphigoid gestationis, and pemphigus vegetans, may show them. However, it is rare to find them in predominant neutrophilic bullous dermatoses such as linear immunoglobulin A. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001690DOI Listing

Balanitis Xerotica Obliterans Associated With Differentiated Penile Intraepithelial Neoplasia and "Bramble-Bush" Elastic Fibers Accumulation: A Finding Not Specific for Penicillamine Intake.

Am J Dermatopathol 2020 May 28. Epub 2020 May 28.

Department of Dermatology, Hospital Arnau de Vilanova, Valencia, Spain.

We describe the association of balanitis xerotica obliterans and differentiated penile intraepithelial neoplasia (PeIN) with dermal elastosis and "bramble-bush" elastic fibers in a diabetic patient with no history of penicillamine intake. An 84-year-old man presented with urethral obstruction syndrome that required postectomy, meatotomy, and foreskin excision. Histopathological examination revealed changes of lichen sclerosus and differentiated PeIN. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001692DOI Listing

Disseminated Histoplasmosis Diagnosed by "Touch Prep".

Am J Dermatopathol 2020 May 28. Epub 2020 May 28.

Departments of Dermatology, and.

Disseminated histoplasmosis is a rare but serious complication of infection with the dimorphic fungus Histoplasma capsulatum. We report a case of disseminated histoplasmosis with cutaneous involvement diagnosed by touch wet preparation and confirmed with histopathology and culture. "Touch prep" performed from a lesional punch biopsy, prepared with Wright-Giemsa followed by chlorazol black containing KOH, revealed abundant yeast organisms localized within multinucleated giant cells, and a rapid diagnosis of disseminated histoplasmosis with cutaneous involvement was achieved. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001578DOI Listing

Noninflammatory Retiform Purpura: Challenge.

Am J Dermatopathol 2020 May 21. Epub 2020 May 21.

Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC.

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http://dx.doi.org/10.1097/DAD.0000000000001554DOI Listing

Photodistributed Rash Progressing to Erythroderma: Answer.

Am J Dermatopathol 2020 Jun;42(6):463-465

Section of Dermatopathology, Department of Pathology, University of Virginia Health System, Charlottesville, VA.

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http://dx.doi.org/10.1097/DAD.0000000000001413DOI Listing

An 81-Year-Old Man With a Growth on the Areola: Answer.

Am J Dermatopathol 2020 Jun;42(6):461-462

Department of Dermatology, Saint Louis University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1097/DAD.0000000000001382DOI Listing

Recurrent Pruritic Papules and Reticulated Hyperpigmentation in a Young Woman: Answer.

Am J Dermatopathol 2020 Jun;42(6):458-459

Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/DAD.0000000000001405DOI Listing

A Long-Term Study of Persistent Sézary Syndrome: Evidence for Antigen Shift by Multiparameter Flow Cytometry and Its Significance in Overall Survival.

Am J Dermatopathol 2020 Jun;42(6):389-396

Associate Professor, Department of Pathology, University of California San Francisco, San Francisco CA.

Sézary syndrome (SS) is a peripheral T-cell lymphoma characterized by erythroderma, diffuse lymphadenopathy, and circulating neoplastic T cells, which classically show a helper T-cell immunophenotype with loss of CD7 and CD26. Flow cytometry is often used to identify and enumerate populations of Sézary cells in the peripheral blood; however, the significance and frequency of antigen shift over time is unclear. In this article, we follow the immunophenotype of the neoplastic T-cell population from 28 patients with SS across 415 flow cytometry studies. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001637DOI Listing

Letter to the Editor.

Am J Dermatopathol 2020 May 19. Epub 2020 May 19.

Mycology Section and Dermatopathology Department "Dr. Manuel Gea Gonzalez" General Hospital, CDMX, Mexico.

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http://dx.doi.org/10.1097/DAD.0000000000001684DOI Listing

Clinicopathological Features of Seborrheic-Like Dermatitis in HIV-Infected Adults: A Single Institutional Descriptive Cross-Sectional Study.

Am J Dermatopathol 2020 May 1. Epub 2020 May 1.

Division of Anatomical Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University and National Health Laboratory Service, Tygerberg Academic Hospital, Cape Town, South Africa.

Background: Atypical and severe clinical presentations of seborrheic-like dermatitis (SLD) are associated with HIV infection, correlating with advanced disease or low CD4 counts. Previous studies documented histological findings characteristic of seborrheic dermatitis in HIV-positive patients.

Objective: To expand current knowledge of the clinicopathological characteristics of SLD in South African HIV-seropositive individuals. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001670DOI Listing

Epithelioid Fibrous Histiocytoma With Dot-Like Perinuclear ALK Expression and PRKAR2A-ALK Fusion.

Am J Dermatopathol 2020 May 1. Epub 2020 May 1.

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR.

Epithelioid fibrous histiocytoma (EFH) is a rare, benign, cutaneous neoplasm. This fibrohistiocytic tumor was once believed to be a variant of fibrous histiocytoma, but EFH is now known to be a distinct entity based on the presence of ALK gene rearrangements in most cases. The pattern of immunohistochemical expression of ALK in EFH in the literature thus far describes both granular cytoplasmic staining and nuclear staining. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001666DOI Listing

Pedunculated Perianal Mass in a Neonate: A Rare Case Report.

Am J Dermatopathol 2020 May 1. Epub 2020 May 1.

Department of Paediatric Surgery, IGICH, Bangalore, India.

Congenital perianal pedunculated masses are a rare occurrence in neonates. They are benign in nature and can be excised completely for definitive diagnosis. Here is a report of a rare case of pedunculated perianal mass occurring in a neonate managed successfully. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001640DOI Listing

Hansen Disease (Leprosy) and Armadillo Exposure in Arkansas: A Case Series.

Am J Dermatopathol 2020 May 1. Epub 2020 May 1.

Hull Dermatology, PA, Rogers, AR.

Background: Although most cases of Hansen disease (HD) in the United States are imported from endemic areas, a subset of cases are relate to exposure to nine-banded armadillos. Several recent cases of HD in Arkansas occurred in patients who had not traveled to endemic areas and who reported variable degrees of armadillo exposure.

Objective: The purpose of this study was to report 6 cases of HD diagnosed in Arkansas between 2004 and 2016. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001660DOI Listing

Cutaneous Adenosquamous Carcinoma of the Scalp With Intestinal Phenotype.

Am J Dermatopathol 2020 May 5. Epub 2020 May 5.

Department of Pathology, Centre Hospitalier Lyon-Sud, Pierre Bénite, France.

Cutaneous adenosquamous carcinoma is a mixed, squamous and glandular, rare malignant tumor of the skin characterized by a mixed, squamous, and glandular differentiation. Few cases of this tumor have been so far reported, and even fewer have been thoroughly studied by immunohistochemistry. We report here an exceptional case of cutaneous adenosquamous carcinoma which showed immunohistochemically features of intestinal differentiation, namely because of the expression of keratin 20 and CDX2, a marker of gastrointestinal tumors. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001671DOI Listing

Dendritic Cell Neurofibroma With Pseudorosettes: A Variant of Neurofibroma?

Am J Dermatopathol 2020 Apr 21. Epub 2020 Apr 21.

Dermatopathology Bodensee, Friedrichshafen, Germany.

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http://dx.doi.org/10.1097/DAD.0000000000001665DOI Listing

Clear Cell Sarcoma With Cutaneous Presentation in a 4-Year-Old Boy.

Am J Dermatopathol 2020 Apr 21. Epub 2020 Apr 21.

Department of Pathology, The University of Virginia, Charlottesville, VA.

We report a case of a 4-year-old Brazilian boy, who presented with an erythematous and painful nodule involving the skin of his left arm. Immunohistochemistry was performed for S100, SOX10, CD34, desmin, SMA, HMB-45, CD1a, and CD163, and fluorescence in situ hybridization for EWSR1 gene rearrangement using a break-apart probe was completed. Immunohistochemistry showed bland spindle cells with "floret-like" appearance simulating a giant cell fibroblastoma; tumor cells were positive for S100 and SOX10; neoplastic cells were negative for CD34, desmin, SMA, HMB-45, CD1a, and CD163; and fluorescence in situ hybridization showed an EWSR1 gene rearrangement. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001658DOI Listing

Syphilitic Chancre of the Lip.

Am J Dermatopathol 2020 Apr 21. Epub 2020 Apr 21.

Department of Cellular Pathology, Hospital Universitario El Bierzo, Ponferrada, Spain.

Syphilis is a sexually transmitted disease caused by Treponema pallidum. The primary stage of the disease (the chancre) mainly involves the genital areas. Extragenital areas are involved in 5%-14% of cases, many of which occur in the oral cavity. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001659DOI Listing