6,385 results match your criteria American Journal Of Dermatopathology[Journal]


A Fast-Growing Tumor on the Head of an Elderly Woman: Challenge.

Am J Dermatopathol 2022 07;44(7):e71-e74

Department of Pathology, Hospital Clínico Universitario de Valencia, Universidad de Valencia, Valencia, Spain.

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Multiple Nodules on the Bilateral Lower Extremities: Challenge.

Am J Dermatopathol 2022 07;44(7):e69-e70

Department of Dermatology, Mayo Clinic, Rochester, MN; and.

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Recurrent Papular Eruption: Challenge.

Am J Dermatopathol 2022 07;44(7):e67-e68

National Skin Centre, Singapore; and.

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A Fast-Growing Tumor on the Head of an Elderly Woman: Answer.

Am J Dermatopathol 2022 07;44(7):535-536

Department of Pathology, Hospital Clínico Universitario de Valencia, Valencia, Spain, Universidad de Valencia, Valencia, Spain.

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Multiple Nodules on the Bilateral Lower Extremities: Answer.

Am J Dermatopathol 2022 07;44(7):534

Department of Dermatology, Mayo Clinic, Rochester, MN; and.

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Recurrent Papular Eruption: Answer.

Am J Dermatopathol 2022 07;44(7):532-533

National Skin Centre, Singapore; and.

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Lupus Erythematosus Tumidus: Clinical and Pathological Features in a Series of 20 Patients.

Am J Dermatopathol 2022 Jul 1;44(7):469-477. Epub 2021 Nov 1.

Passant, Faculty of Engineering, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Objective: We sought to assess the clinicopathologic/immunophenotypical features in patients with lupus erythematosus tumidus (LET).

Methods: All skin biopsies diagnosed as LET in 16 years were retrieved from our pathology laboratory. Clinical charts were reviewed and immunohistochemical markers were performed. Read More

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Eccrine Squamous Syringometaplasia Associated With Lichen Sclerosus et Atrophicus.

Am J Dermatopathol 2022 May 30. Epub 2022 May 30.

Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.

Abstract: Eccrine squamous syringometaplasia (ESS) has been associated with several conditions including morphea, linear scleroderma, and burns. It is yet to be reported in lichen sclerosus et atrophicus (LSA). We describe a bullous LSA plaque on the forearm of a woman with pre-existing genital LSA and vitiligo. Read More

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Large Cell Neuroendocrine Carcinoma of the Skin/Conjunctiva: A Series of 6 Cases including 1 Combined Case With Squamous Cell Carcinoma.

Am J Dermatopathol 2022 May 30. Epub 2022 May 30.

Department of Diagnostic Pathology, Shizuoka Cancer Center Hospital, Sunto, Japan.

Abstract: This study sought to reveal the clinicopathologic characteristics of large cell neuroendocrine carcinoma (LCNEC) of the skin/conjunctiva. The retrieved patients included 3 men and 3 women with a median age of 85 (63-95) years. All lesions occurred on the face, including the ears, with a median tumor size of 11. Read More

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Verrucous Melanoma Presenting as a Cutaneous Horn.

Am J Dermatopathol 2022 May 30. Epub 2022 May 30.

Department of Dermatology, The University of Texas at Austin Dell Medical School, Austin, TX.

Abstract: Verrucous malignant melanoma (MM) is a rare variant of melanoma that often presents diagnostic challenges. This case highlights the unique presentation of verrucous MM underlying a cutaneous horn. It is vital for dermatologists to be aware of this potentially benign-appearing variant to be able to diagnose and treat MM early on. Read More

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HPV-57 Verruca Vulgaris Mimicking Epidermodysplasia Verruciformis.

Am J Dermatopathol 2022 May 30. Epub 2022 May 30.

Department of Dermatology, Cook County Hospital and Health System, Department of Dermatology, Chicago, IL.

Abstract: Human papilloma virus (HPV) is the causative agent for a variety of cutaneous lesions including verruca vulgaris (VV) and epidermodysplasia verruciformis (EDV). There are more than 200 known genotypes of HPV, and specific HPV types are associated with different clinical manifestations and malignant potentials. Herein, we describe a case of a 43-year-old immunocompetent woman who presented with morphologically distinct lesions that were most consistent with EDV on clinical examination. Read More

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Shared Clonal Origin of Multiple Histiocytic and Dendritic Neoplasms and Polycythemia Vera, Follicular Lymphoma in 1 Patient.

Am J Dermatopathol 2022 May 30. Epub 2022 May 30.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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A Woman With a Rapidly Expanding Subungual Mass: Subungual Endometrial Carcinoma Metastasis.

Am J Dermatopathol 2022 May 30. Epub 2022 May 30.

State-Dermatologist at Lanoi Medical Group, San Diego, CA.

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Ciliary Gland Adenocarcinoma of the Eyelid Arising in Hidrocystoma: Case Report and Review of Previously Reported Cases.

Am J Dermatopathol 2022 May 30. Epub 2022 May 30.

St. Joseph Dermpath, Houston, TX.

Abstract: Moll gland is a modified tubular-shaped apocrine sweat gland, which is located on the margin of the eyelid. Moll glands are also known as ciliary glands. The function of these glands was not well known for a long time. Read More

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Multiple Plantar Swellings as the Presenting Sign of a Systemic Disease: Challenge.

Am J Dermatopathol 2022 06;44(6):e60

Department of Dermatology, Kasr Alainy Hospital, Faculty of Medicine, Cairo University,Giza, Egypt.

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A 72-Year-Old Woman With Hemorrhagic Bullae Over the Dorsal Hand: Challenge.

Am J Dermatopathol 2022 06;44(6):e58-e59

Department of Dermatology, University of Nebraska Medical Center, Omaha, NE.

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Multiple Recurrent Plaques on Truck and Face: Challenge.

Am J Dermatopathol 2022 06;44(6):e57

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX.

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Multiple Plantar Swellings as the Presenting Sign of a Systemic Disease: Answer.

Am J Dermatopathol 2022 06;44(6):464

Department of Dermatology, Kasr Alainy Hospital, Faculty of Medicine, Cairo University, Giza, Egypt.

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A 72-Year-Old Woman With Hemorrhagic Bullae Over the Dorsal Hand: Answer.

Am J Dermatopathol 2022 06;44(6):463

Department of Dermatology, University of Nebraska Medical Center, Omaha, NE.

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Multiple Recurrent Plaques on the Truck and Face: Answer.

Am J Dermatopathol 2022 06;44(6):461-462

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX.

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Histological Transformation and Clonal Relationship of Subcutaneous Marginal Zone B-Cell Lymphoma and Diffuse Large B-Cell Lymphoma.

Am J Dermatopathol 2022 Jun 22;44(6):442-448. Epub 2022 Mar 22.

Departments of Dermatology.

Abstract: Histological transformation (HT) is an exceptionally uncommon and poorly understood event where a low-grade or indolent B-cell lymphoma transforms into a more aggressive entity, typically diffuse large B-cell lymphoma (DLBCL). The pathogenesis is unclear; however, HT is associated with a worse prognosis. This article reports a unique case of marginal zone lymphoma (MZL) limited to skin/subcutis (confirmed with PET-CT) that subsequently developed DLBCL, followed by nodal MZL. Read More

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Eosinophilic Pustular Folliculitis of Infancy: A Histologic Assessment of 43 Cases.

Am J Dermatopathol 2022 Jun 5;44(6):395-403. Epub 2021 Aug 5.

Consultant Physician, Pathologist, Department of Pathology, Necker-Enfants Malades Hospital, and Reference Center for Genodermatoses, Necker-Enfants Malades Hospital, Paris, France.

Abstract: Eosinophilic pustular folliculitis of infancy is a sterile, inflammatory dermatosis that mainly affects children younger than 36 months. The underlying physiopathologic mechanism is unclear. Clinical diagnosis is challenging, and a skin biopsy may be necessary. Read More

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Actionable Mutation Profile of Sun-Protected Melanomas in South America.

Am J Dermatopathol 2022 May 3. Epub 2022 May 3.

Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.

Abstract: Melanomas that arise in sun-protected sites, including acral and oral mucosal melanomas, are likely under the control of unique, specific mechanisms that lead to mutagenesis through various pathways. In this study, we examined somatic mutations in tumors by targeted sequencing using a custom Ion Ampliseq Panel, comprising hotspots of 14 genes that are frequently mutated in solid tumors. Tumor DNA was extracted from 9 formalin fixation, paraffin-embedded sun-protected melanomas (4 primary oral mucosal melanomas and 5 acral lentiginous melanomas), and we identified mutations in the NRAS, PIK3CA, EGFR, HRAS, ERBB2, and ROS1 genes. Read More

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A Rare Case of Myxochondroid Metaplasia of the Plantar Foot With Review of Histopathological Mimics.

Am J Dermatopathol 2022 Apr 27. Epub 2022 Apr 27.

Departments of Pathology, and.

Abstract: Chondromyxoid metaplasia can rarely lead to the formation of a distinctive tumor-like proliferation in the plantar foot. This is thought to represent a reactive or reparative process, possibly due to chronic trauma. For the unwary dermatopathologist, this could represent a diagnostic challenge. Read More

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Metastasis to the Oral Cavity: Report of 12 Cases.

Am J Dermatopathol 2022 May 3. Epub 2022 May 3.

Department of Dermatology, Medical School, Hospital das Clinicas, University of São Paulo, São Paulo, Brazil.

Abstract: Oral cavity is not a common route for metastatic dissemination; metastasis to the oral region may affect soft tissues and jawbones, accounting for approximately 1% of all oral malignant neoplasms. The diagnosis of metastatic lesions to the oral cavity is usually challenging to clinicians and pathologists because of their complexity and rarity. We present a series of 12 metastatic neoplasms to the oral cavity that were detected previously or after the diagnosis of the primary tumor. Read More

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Connexin 43 Expression in Cutaneous Biopsies of Lupus Erythematosus.

Am J Dermatopathol 2022 May 3. Epub 2022 May 3.

Department of Research, Institute for Biomedical Research of A Coruña (INIBIC), University of A Coruña (UDC), A Coruña, Spain.

Introduction: Gap junctions are channels between adjacent cells formed by connexins (Cxs). Cxs also form hemichannels that connect the cell with its extracellular milieu. These channels allow the transport of ions, metabolites, and small molecules; therefore, Cxs, and more specifically, connexin (Cx) 43 has been demonstrated to be in control of several crucial events such as inflammation and cell death. Read More

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PRAME Expression Correlates With Genomic Aberration and Malignant Diagnosis of Spitzoid Melanocytic Neoplasms.

Am J Dermatopathol 2022 Apr 27. Epub 2022 Apr 27.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Abstract: Spitzoid melanocytic neoplasms are a diagnostically challenging class of lesions in dermatopathology. Recently, molecular assays and immunohistochemical markers have been explored as ancillary methods to assist in the diagnostic workup. Specifically, preferentially expressed antigen in melanoma (PRAME) immunohistochemistry is a nuclear stain commonly positive in melanomas, but not in nevi. Read More

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A Case of Tofacitinib-Induced Lymphomatoid Papulosis With Ocular Involvement.

Am J Dermatopathol 2022 Jul 4;44(7):523-525. Epub 2022 May 4.

Department of Dermatology, Oregon Health and Science University, Portland, OR.

Abstract: Janus kinase (JAK) inhibitors are being prescribed with increasing regularity in dermatology. We report on a patient who initiated treatment with tofacitinib for refractory erythema elevatum diutinum and subsequently developed a novel cutaneous outbreak characterized by firm violaceous papules on the trunk and extremities along with conjunctival injection and periorbital inflammation. Biopsy of affected tissue from both the cutaneous and ophthalmologic sources demonstrated increased numbers of CD30+ large atypical cells amid a mixed inflammatory cell infiltrate, consistent with lymphomatoid papulosis. Read More

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Clinicopathologic Features of Facial Dermatofibromas, a Cohort Study, and a Systematic Review of Literature.

Am J Dermatopathol 2022 Apr 27. Epub 2022 Apr 27.

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA.

Background: Dermatofibromas are common skin tumors that typically occur on the extremities and trunk and demonstrate benign behavior, frequent recurrences, and very rare metastasis. Facial dermatofibromas are rare and not well studied. We analyzed clinicopathologic features of facial dermatofibromas. Read More

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Next-Generation Sequencing Reveals a New Class of Melanocytic Neoplasms With Hybrid Genomic Features of PEM Including Protein Kinase R 1 Alpha Gene Inactivation and Spitz Tumor-Defining Protein Kinase Fusions.

Am J Dermatopathol 2022 May 3. Epub 2022 May 3.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Background: Pigmented epithelioid melanocytoma (PEM) is a subtype of melanocytic tumor with frequent involvement of the sentinel lymph node but rare distant metastasis. Rendering a diagnosis and prognosis based on histology can be challenging. Recent genomic studies identified 2 molecular variants of PEM. Read More

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