2,551 results match your criteria American Journal Of Chinese Medicine[Journal]


Thymoquinone Attenuates Acetaminophen Overdose-Induced Acute Liver Injury and Inflammation Via Regulation of JNK and AMPK Signaling Pathway.

Am J Chin Med 2019 Apr 11:1-18. Epub 2019 Apr 11.

* Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Clinical Research Center, Yanbian University Hospital, Yanji 133002, Jilin Province, China.

Thymoquinone (TQ) is a main aromatic component of Nigella sativa L. seeds or Agastache rugosa (Fisch. & C. Read More

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http://dx.doi.org/10.1142/S0192415X19500307DOI Listing
April 2019
2.625 Impact Factor

Curcumin Promotes Connexin 43 Degradation and Temozolomide-Induced Apoptosis in Glioblastoma Cells.

Am J Chin Med 2019 Apr 11:1-18. Epub 2019 Apr 11.

‡ Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan.

Glioblastoma (GBM) is the most commonly occurring tumor in the cerebral hemispheres. Currently, temozolomide (TMZ), an alkylating agent that induces DNA strand breaks, is considered the frontline chemotherapeutic agent for GBM. Despite its frontline status, GBM patients commonly exhibit resistance to TMZ treatment. Read More

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http://dx.doi.org/10.1142/S0192415X19500344DOI Listing

Scutellaria Radix Promotes Apoptosis in Non-Small Cell Lung Cancer Cells via Induction of AMPK-Dependent Autophagy.

Am J Chin Med 2019 Apr 11:1-15. Epub 2019 Apr 11.

* Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

Scutellaria Radix (SR) is an herb traditionally used in Asian countries to treat inflammatory diseases. Recent studies report that SR exhibits anticancer activities in various types of tumors. In this study, we investigated the apoptotic and autophagic effect of SR in non-small cell lung cancer (NSCLC), the leading cause of cancer-associated death. Read More

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http://dx.doi.org/10.1142/S0192415X19500368DOI Listing

ERRATUM: Gypenosides Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis by Inhibiting the Differentiation of Hepatic Progenitor Cells into Myofibroblasts.

Am J Chin Med 2019 Apr 9:1-2. Epub 2019 Apr 9.

* Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

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http://dx.doi.org/10.1142/S0192415X19920010DOI Listing
April 2019
5 Reads

A Systematic Review of Neuroprotective Efficacy and Safety of DL-3-N-Butylphthalide in Ischemic Stroke.

Am J Chin Med 2019 Apr 9:1-19. Epub 2019 Apr 9.

* Department of Pharmacology, Second Military Medical University, Shanghai 200433, P. R. China.

DL-3-n-butylphthalide (NBP) is widely used as a neuroprotective drug for ischemic stroke in China. There is, however, no established evidence on its efficacy and safety for patients with ischemic stroke. We, therefore, conducted a systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1142/S0192415X19500265DOI Listing
April 2019
3 Reads

Aloin Reduces HMGB1-Mediated Septic Responses and Improves Survival in Septic Mice by Activation of the SIRT1 and PI3K/Nrf2/HO-1 Signaling Axis.

Am J Chin Med 2019 Apr 9:1-21. Epub 2019 Apr 9.

* College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.

High mobility group box 1 (HMGB1) is recognized as a late mediator of sepsis, and the inhibition of HMGB1 release and recovery of vascular barrier integrity have emerged as attractive therapeutic strategies for the management of sepsis. We tested the hypothesis that aloin induces sirtuin 1 (SIRT1) and heme oxygenase (HO)-1, which inhibit HMGB1 release in lipopolysaccharide (LPS)-stimulated cells, thereby inhibiting HMGB1-induced hyperpermeability and increasing the survival of septic mice. Aloin was administered after LPS or HMGB1 challenge, and the antiseptic activity of aloin was determined from measurements of permeability, activation of pro-inflammatory proteins and production of markers for tissue injury in HMGB1-activated human umbilical vein endothelial cells (HUVECs) and a cecal ligation and puncture (CLP)-induced sepsis mouse model. Read More

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http://dx.doi.org/10.1142/S0192415X19500320DOI Listing

Luteolin: A Natural Flavonoid Enhances the Survival of HUVECs against Oxidative Stress by Modulating AMPK/PKC Pathway.

Am J Chin Med 2019 Apr 9:1-17. Epub 2019 Apr 9.

‡ Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan.

Oxidative stress has been implicated in the pathogenesis of atherosclerotic cardiovascular diseases. Dietary supplementation of anti-oxidants has been reported to have beneficial effects on the prevention of atherogenic diseases. Luteolin (a natural flavonoid) has been shown to possess antimutagenic, antitumorigenic, anti-oxidant and anti-inflammatory properties. Read More

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http://dx.doi.org/10.1142/S0192415X19500289DOI Listing

Acupuncture Inhibits the Increase in Alpha-Synuclein by Modulating SGK1 in an MPTP Induced Parkinsonism Mouse Model.

Am J Chin Med 2019 Apr 9:1-13. Epub 2019 Apr 9.

† Department of Meridian and Acupoint, College of Korean Medicine, and WHO Collaborating Center for Traditional Medicine, East-West Medical Research Institute, Kyung Hee University, Seoul 130-701, Republic of Korea.

Parkinson's disease (PD), a progressive neurodegenerative disease, is caused by the loss of dopaminergic neurons in the substantia nigra (SN). It is characterized by the formation of intracytoplasmic Lewy bodies that are primarily composed of the protein alpha-synuclein ( -syn) along with dystrophic neurites. Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in parkinsonism animal models. Read More

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http://dx.doi.org/10.1142/S0192415X19500277DOI Listing

β-Pentagalloyl-Glucose Sabotages Pancreatic Cancer Cells and Ameliorates Cachexia in Tumor-Bearing Mice.

Am J Chin Med 2019 Apr 9:1-15. Epub 2019 Apr 9.

† The Institute of Integrative Medicine for Acute Abdominal Diseases, Nankai Hospital, Tianjin 300100, P. R. China.

Pancreatic cancer cells overexpress the insulin receptor (IR) and the insulin-like growth factor-1 receptor (IGF1R). Activating these receptors, insulin and insulin-like growth factor-1 increase the growth and glycolysis of pancreatic cancer cells. The high glycolysis in pancreatic cancer cells increases whole-body energy expenditure and is therefore involved in the pathogenesis of cancer cachexia. Read More

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http://dx.doi.org/10.1142/S0192415X19500356DOI Listing

Carnosine Suppresses Human Colorectal Cell Migration and Intravasation by Regulating EMT and MMP Expression.

Am J Chin Med 2019 ;47(2):477-494

¶ Department of Food and Nutrition, Providence University, Taichung 43301, Taiwan.

Carnosine is an endogenous dipeptide found in the vertebrate skeletal muscles that is usually obtained through the diet. To investigate the mechanism by which carnosine regulates the migration and intravasation of human colorectal cancer (CRC) cells, we used cultured HCT-116 cells as an experimental model in this study. We examined HCT-116 cell migratory and intravasive abilities and expression of epithelial-mesenchymal transition (EMT)-associated molecules and matrix metalloproteinases (MMPs) after carnosine treatment. Read More

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http://dx.doi.org/10.1142/S0192415X19500241DOI Listing
January 2019

A Randomized Clinical Efficacy Trial of Red Yeast Rice (Monascus pilosus) Against Hyperlipidemia.

Am J Chin Med 2019 14;47(2):323-335. Epub 2019 Mar 14.

* Division of Chinese Internal Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Red yeast rice (RYR) has been used as an alternative treatment for hyperlipidemia. According to the previous studies, other compounds, besides monacolin K in RYR, may also reduce the serum lipid level. This study aims at examining the efficacy of monacolin K-rich and Gamma-Aminobutyric Acid (GABA)-rich RYR (Monascus pilosus) with regards to treating hyperlipidemia in a randomized control, double-blind clinical trial. Read More

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http://dx.doi.org/10.1142/S0192415X19500150DOI Listing

Cafestol Activates Nuclear Factor Erythroid-2 Related Factor 2 and Inhibits Urotensin II-Induced Cardiomyocyte Hypertrophy.

Am J Chin Med 2019 14;47(2):337-350. Epub 2019 Mar 14.

¶ Division of Cardiology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Through population-based studies, associations have been found between coffee drinking and numerous health benefits, including a reduced risk of cardiovascular disease. Active ingredients in coffee have therefore received considerable attention from researchers. A wide variety of effects have been attributed to cafestol, one of the major compounds in coffee beans. Read More

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http://dx.doi.org/10.1142/S0192415X19500162DOI Listing

Lonicera japonica Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Mice: Molecular Mechanisms of Action.

Am J Chin Med 2019 14;47(2):351-367. Epub 2019 Mar 14.

1 The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, P. R. China.

Liver fibrosis is a worldwide clinical issue that generally causes hepatic cirrhosis. Lonicerae Japonicae Flos (dried flower buds of Lonicera japonica Thunb) is a traditional heat-clearing and detoxifying herbal medicine in China. This study aims to observe the protection of the water extract of Lonicerae Japonicae Flos (FL) from carbon tetrachloride (CCl)-induced liver fibrosis in mice. Read More

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http://dx.doi.org/10.1142/S0192415X19500174DOI Listing
March 2019
2.625 Impact Factor

Ethnobotany, Phytochemistry and Pharmacological Properties of Eucommia ulmoides: A Review.

Am J Chin Med 2019 11;47(2):259-300. Epub 2019 Mar 11.

* National & Local United Engineering Laboratory of Integrative Utilization Technology of Eucommia Ulmoides, College of Hunan Province, Jishou University, Jishou 416000, P. R. China.

Eucommia ulmoides Oliver, a single species of Eucommia genus belonging to the Eucommiaceae family, is an endemic in China and has been used in traditional Chinese medicine for nearly two thousand years. Records from different historical periods highlight E. ulmoides and its officinal botanical parts, usefulness in adaptation to disease and its central role in Chinese medicine theory. Read More

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http://dx.doi.org/10.1142/S0192415X19500137DOI Listing
March 2019
1 Read

Preventive Effect of Bupleurum chinense on Nasal Inflammation via Suppressing T Helper Type 2, Eosinophil and Mast Cell Activation.

Am J Chin Med 2019 7;47(2):405-421. Epub 2019 Mar 7.

† Department of Anatomy, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea.

Bupleurum chinense is distributed in East Asia and has been used as a traditional herbal medicine for more than a thousand years. Though B. chinense has been reported to have immunomodulatory, anti-inflammatory, anti-oxidant, hepato-protective, antipyretic, analgesic and antifibrotic effects, its specific effect on allergic rhinitis disease has not been clarified. Read More

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http://dx.doi.org/10.1142/S0192415X19500204DOI Listing
March 2019
2 Reads

Sageretia thea Inhibits Inflammation through Suppression of NF- B and MAPK and Activation of Nrf2/HO-1 Signaling Pathways in RAW264.7 Cells.

Am J Chin Med 2019 5;47(2):385-403. Epub 2019 Mar 5.

* Department of Medicinal Plant Resources, National Institute of Forest Science, Yongju 36040, Republic of Korea.

Sageretia thea (S. thea) commonly known as Chinese sweet plum or Chinese bird plum has been used for treating hepatitis and fevers in Korea and China. S. Read More

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http://dx.doi.org/10.1142/S0192415X19500198DOI Listing
March 2019
3 Reads

Protective Effects of Ligustroflavone, an Active Compound from Ligustrum lucidum, on Diabetes-Induced Osteoporosis in Mice: A Potential Candidate as Calcium-Sensing Receptor Antagonist.

Am J Chin Med 2019 5;47(2):457-476. Epub 2019 Mar 5.

* Spine Disease Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P. R. China.

Ligustroflavone is one major compound contained in active fraction from Fructus Ligustri Lucidi (the fruit of Ligustrum lucidum), which could regulate parathyroid hormone (PTH) levels and improve calcium balance by acting on calcium-sensing receptors (CaSR). This study aimed to explore the potency of ligustroflavone as a CaSR antagonist and its protective effects against diabetic osteoporosis in mice. LF interacted well with the allosteric site of CaSR shown by molecular docking analysis, increased PTH release of primary parathyroid gland cells and suppressed extracellular calcium influx in HEK-293 cells. Read More

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http://dx.doi.org/10.1142/S0192415X1950023XDOI Listing
March 2019
2 Reads

Protective Effects of Serotonin and its Derivatives, N-Feruloylserotonin and N-(p-Coumaroyl) Serotonin, Against Cisplatin-Induced Renal Damage in Mice.

Am J Chin Med 2019 4;47(2):369-383. Epub 2019 Mar 4.

* Department of Medicinal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong 369-873, Republic of Korea.

This study examined whether serotonin and two of its derivatives, -feruloylserotonin and -( -coumaroyl) serotonin, have a renoprotective effect in a mouse model of cisplatin-induced acute renal failure. Cisplatin (20 mg/kg body weight) was administered by intraperitoneal injection to male BALB/c mice that had received oral serotonin, -feruloylserotonin or -( -coumaroyl) serotonin (7.5 mg/kg body weight per day) during the preceding 2 days. Read More

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http://dx.doi.org/10.1142/S0192415X19500186DOI Listing

Dioscin, a Steroidal Saponin Isolated from Dioscorea nipponica, Attenuates Collagen-Induced Arthritis by Inhibiting Th17 Cell Response.

Am J Chin Med 2019 4;47(2):423-437. Epub 2019 Mar 4.

† The No. 1 Affiliated Hospital of Yunnan, University of Traditional Chinese Medicine, Kunming 650021, P. R. China.

Dioscin, a steroidal saponin isolated from Dioscorea nipponica Makino, has previously been shown to possess antiarthritic effects. However, the underlying mechanism is still elusive. Herein, we investigated the therapeutic effects of dioscin on collagen-induced arthritis (CIA) in DBA/1 mice and related mechanism. Read More

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http://dx.doi.org/10.1142/S0192415X19500216DOI Listing

Physical and Psychological Health Outcomes of Qigong Exercise in Older Adults: A Systematic Review and Meta-Analysis.

Am J Chin Med 2019 4;47(2):301-322. Epub 2019 Mar 4.

† School of Nursing, Yale University, Connecticut 06511, USA.

Physical limitations, depression and anxiety are prevalent among older adults. Mild to moderate exercise can promote physical and psychological health and reduce the risk of chronic diseases. Qigong, a type of Chinese traditional medicine exercise, has demonstrated beneficial effects on physical ability and mental health in adults with chronic conditions. Read More

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http://dx.doi.org/10.1142/S0192415X19500149DOI Listing

Berberine Suppresses RANKL-Induced Osteoclast Differentiation by Inhibiting c-Fos and NFATc1 Expression.

Am J Chin Med 2019 4;47(2):439-455. Epub 2019 Mar 4.

1 Department of Herbal Medicine, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, Korea.

Osteoporosis is a common disorder of bone remodeling, marked by excessive osteoclast formation. Recent studies indicated that berberine (BBR) is a potential natural drug for the treatment of various bone diseases. However, it still needs to be further studied for the treatment of osteoporosis. Read More

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https://www.worldscientific.com/doi/abs/10.1142/S0192415X195
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http://dx.doi.org/10.1142/S0192415X19500228DOI Listing
March 2019
4 Reads

Clinopodium chinense Attenuates Palmitic Acid-Induced Vascular Endothelial Inflammation and Insulin Resistance through TLR4-Mediated NF- B and MAPK Pathways.

Am J Chin Med 2019 ;47(1):97-117

* Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, P. R. China.

Elevated palmitic acid (PA) levels are associated with the development of inflammation, insulin resistance (IR) and endothelial dysfunction. Clinopodium chinense (Benth.) O. Read More

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http://dx.doi.org/10.1142/S0192415X19500058DOI Listing
March 2019
2 Reads

Suppressive Effects of Ginsenoside Rh1 on HMGB1-Mediated Septic Responses.

Am J Chin Med 2019 10;47(1):119-133. Epub 2019 Jan 10.

§ College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.

High mobility group box 1 (HMGB1) is considered as a late mediator of sepsis and the inhibition of HMGB1-mediated severe inflammatory responses, and restoration of endothelial integrity have emerged as attractive therapeutic strategies for the management of sepsis. Ginsenoside Rh1, a protopanaxatriol type ginsenoside, is one of the major bioactive components of Korean red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. Ginsenoside Rh1 exhibits potent biological activities such as antistress, anti-oxidant, anti-inflammatory and immunomodulatory effects. Read More

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https://www.worldscientific.com/doi/abs/10.1142/S0192415X195
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http://dx.doi.org/10.1142/S0192415X1950006XDOI Listing
March 2019
7 Reads

Casticin Promotes Immune Responses, Enhances Macrophage and NK Cell Activities, and Increases Survival Rates of Leukemia BALB/c Mice.

Am J Chin Med 2019 10;47(1):223-236. Epub 2019 Jan 10.

§§ Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Casticin, derived from Fructus Viticis, has anticancer properties in many human cancer cells, however, there is no report to show that casticin promotes immune responses and affects the survival rate of leukemia mice in vivo. The aim of this study is to evaluate the effects of casticin on immune responses and the survival rate of WEHI-3 cells generated in leukemia mice in vivo. Animals were divided into six groups: normal control mice, leukemia control mice, mice treated with ATRA (all-trans retinoic acid), and casticin (0. Read More

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http://dx.doi.org/10.1142/S0192415X19500113DOI Listing

Herbal Medicines with Antiviral Activity Against the Influenza Virus, a Systematic Review.

Am J Chin Med 2018 ;46(8):1663-1700

* Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Columbus, Ohio, USA.

The rapidly changing influenza virus has remained a consistent threat to the well-being of a variety of species on the planet. Influenza virus' high mutation rate has allowed the virus to rapidly and continuously evolve, as well as generate new strains that are resistant to the current commercially available antivirals. Thus, the increased resistance has compelled the scientific community to explore alternative compounds that have antiviral effects against influenza virus. Read More

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https://www.worldscientific.com/doi/abs/10.1142/S0192415X185
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http://dx.doi.org/10.1142/S0192415X18500854DOI Listing
February 2019
2 Reads

Total Glycosides of Peony Protects Against Inflammatory Bowel Disease by Regulating IL-23/IL-17 Axis and Th17/Treg Balance.

Am J Chin Med 2019 7;47(1):177-201. Epub 2019 Jan 7.

† School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, P. R. China.

Inflammatory bowel disease (IBD) is a group of autoimmune diseases, including ulcerative colitis and Crohn's disease, characterized by nonspecific inflammation in the gut. Total glycoside of peony (TGP) has been widely used for treatment of autoimmune diseases because of its pharmacological effects. However, it is lack of depth in whether TGP regulate T helper 17 cell (Th17) / T regulatory cell (Treg) immune balance or interleukin 23 (IL-23) / IL-17 axis to achieve the goal of treating IBD. Read More

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https://www.worldscientific.com/doi/abs/10.1142/S0192415X195
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http://dx.doi.org/10.1142/S0192415X19500095DOI Listing
March 2019
13 Reads

Rhein, An Anthraquinone Drug, Suppresses the NLRP3 Inflammasome and Macrophage Activation in Urate Crystal-Induced Gouty Inflammation.

Am J Chin Med 2019 7;47(1):135-151. Epub 2019 Jan 7.

* Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Rhein, an anthraquinone drug, is a widely used traditional Chinese medicine. Rhein is a major bioactive metabolite of diacerein which has been approved for treating osteoarthritis with a good safety profile in humans. Gouty arthritis is an inflammatory disease characterized by urate crystal-induced NLRP3 inflammasome activation with up-regulated caspase-1 protease and IL-1 in macrophages. Read More

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http://dx.doi.org/10.1142/S0192415X19500071DOI Listing
March 2019
13 Reads

In Vitro and In Vivo Protective Effects of Flavonoid-Enriched Lotus Seedpod Extract on Lipopolysaccharide-Induced Hepatic Inflammation.

Am J Chin Med 2019 7;47(1):153-176. Epub 2019 Jan 7.

* Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung City 40201, Taiwan.

Endotoxin lipopolysaccharide (LPS) plays an important role in the acceleration of hepatic inflammation. Natural medicinal plants that can prevent inflammation by targeting LPS have potential therapeutic clinical application. The aim of the study is to examine the anti-inflammatory effects of lotus seedpod extract (LSE), used as a traditional Chinese herbal medicine with hemostasis function and for eliminating bruise, on the LPS-induced hepatic inflammation and its underlying molecular mechanisms in vitro and in vivo. Read More

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http://dx.doi.org/10.1142/S0192415X19500083DOI Listing
March 2019
18 Reads

Puerarin Reduces Blood Pressure in Spontaneously Hypertensive Rats by Targeting eNOS.

Am J Chin Med 2019 7;47(1):19-38. Epub 2019 Jan 7.

* Cardiovascular Laboratory, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.

Puerarin is an isoflavonoid isolated from the root of Pueraria lobata (Gegen in Chinese) that has been widely used to treat cardiovascular and cerebrovascular diseases in China. Here, we investigated the hypotensive effects and mechanisms of puerarin in spontaneously hypertensive rats. The qPCR array technique was used to determine the expression of hypertension-related genes. Read More

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http://dx.doi.org/10.1142/S0192415X19500022DOI Listing
March 2019
11 Reads

Ferulic Acid Exerts Anti-apoptotic Effects against Ischemic Injury by Activating HSP70/Bcl-2- and HSP70/Autophagy-Mediated Signaling after Permanent Focal Cerebral Ischemia in Rats.

Am J Chin Med 2019 7;47(1):39-61. Epub 2019 Jan 7.

‡ Research Center for Chinese Medicine & Acupuncture Science, China Medical University, Taichung 40402, Taiwan.

This study assessed the anti-apoptotic effects of the administration of ferulic acid (FrA) in rats 30 min before middle cerebral artery occlusion (MCAo) followed by 3 d of ischemia and the involvement of 70 kDa heat shock protein (HSP70)-mediated signaling in the penumbral cortex. Our results demonstrated that FrA pretreatment at doses of 80 mg/kg (FrA-80 mg) and 100 mg/kg (FrA-100 mg) effectively ameliorated neurological functions and reduced the numbers of cytochrome c-, cleaved caspase-3-, and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells in the penumbral cortex 3 d after ischemia. Moreover, FrA-80 mg and FrA-100 mg pretreatment markedly upregulated cytosolic HSP70, Beclin-1, microtubule-associated protein 1 light chain 3 (LC3) A/B-II and autophagy-related protein 5 (Atg5) expression; cytosolic and mitochondrial X-linked inhibitor of apoptosis (XIAP) expression and the Bcl-2/Bax ratio. Read More

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http://dx.doi.org/10.1142/S0192415X19500034DOI Listing
March 2019
9 Reads

A Guideline for Randomized Controlled Trials of Acupuncture.

Am J Chin Med 2019 7;47(1):1-18. Epub 2019 Jan 7.

* School of Chinese Medicine, The University of Hong Kong, Hong Kong, China.

Guidelines for clinical trials of acupuncture are scarce, particularly in their guidance on choosing an adequate control in an acupuncture trial. This guideline was developed to address the research methodology for clinical research in acupuncture which contains the essential elements to be considered in the design, preparation and reporting of an acupuncture RCT. Particularly, investigators focused on the control design because of the unique feature of acupuncture. Read More

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March 2019
12 Reads
2.625 Impact Factor

Bufalin Induces Apoptotic Cell Death in Human Nasopharyngeal Carcinoma Cells through Mitochondrial ROS and TRAIL Pathways.

Am J Chin Med 2019 7;47(1):237-257. Epub 2019 Jan 7.

* Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.

The aim of this study was to investigate the effects of bufalin on human nasopharyngeal carcinoma NPC-TW 076 cells in vitro. Bufalin is a cardiotonic steroid and a key active ingredient of the Chinese medicine ChanSu. The extracts of Chansu are used for various cancer treatments in China. Read More

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http://dx.doi.org/10.1142/S0192415X19500125DOI Listing

Anticolitic Effect of Viscum coloratum through Suppression of Mast Cell Activation.

Am J Chin Med 2019 7;47(1):203-221. Epub 2019 Jan 7.

1 Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu 41062, Republic of Korea.

Viscum coloratum has been used as a component for traditional medicine for therapy of inflammatory diseases. Nonetheless, effect of Viscum coloratum on inflammatory bowel disease is unknown. Therefore, we investigated whether the ethanol extract of Viscum coloratum (VCE) could suppress inflammatory responses in dextran sodium sulfate (DSS)-treated mice and mast cell-derived inflammatory mediator (MDIM)-activated Caco-2 cells. Read More

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March 2019
12 Reads

Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3.

Am J Chin Med 2019 7;47(1):63-95. Epub 2019 Jan 7.

* Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 33302, Taiwan.

Nine autosomal dominant spinocerebellar ataxias (SCAs) are caused by an abnormal expansion of CAG trinucleotide repeats that encodes a polyglutamine (polyQ) tract within different genes. Accumulation of aggregated mutant proteins is a common feature of polyQ diseases, leading to progressive neuronal dysfunction and degeneration. SCA type 3 (SCA3), the most common form of SCA worldwide, is characterized by a CAG triplet expansion in chromosome 14q32. Read More

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http://dx.doi.org/10.1142/S0192415X19500046DOI Listing
March 2019
10 Reads

High-Throughput Electrophysiology Screen Revealed Cardiotoxicity of Strychnine by Selectively Targeting hERG Channel.

Am J Chin Med 2018 14;46(8):1825-1840. Epub 2018 Dec 14.

1 Tianjin State Key Laboratory of Modern, Chinese Medicine, Tianjin University of Traditional, Chinese Medicine, Tianjin 300193, P. R. China.

Although the efficacy and the health care advantages of Chinese herbal medicine (CHM) have become increasingly recognized worldwide, the potential side effects and toxicity still restrict its broader application. This study established and applied an integrated platform anchored on automatic patch clamp system to screen and evaluate a collection of CHM extracts, compositions and monomeric compounds for in vitro cardiac toxicity. Of 1036 CHM samples screened, 2. Read More

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https://www.worldscientific.com/doi/abs/10.1142/S0192415X185
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February 2019
11 Reads

Polydatin Attenuates Atherosclerosis in ApoE Mice through PBEF Mediated Reduction of Cholesterol Deposition.

Am J Chin Med 2018 11;46(8):1841-1859. Epub 2018 Dec 11.

† School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, P. R. China.

Cholesterol metabolism becomes imbalanced during the formation of macrophage-derived foam cells. Pre-B-cell colony-enhancing factor (PBEF) has recently been found to affect lipid deposition and inflammation in atherosclerosis. Here, we aimed to study the effects and molecular mechanism of Polydatin on atherosclerosis in ApoE-knockout (ApoE ) mice. Read More

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February 2019
2 Reads

Pharmacological Effects and Mechanisms of Chinese Medicines Modulating NLRP3 Inflammasomes in Ischemic Cardio/Cerebral Vascular Disease.

Am J Chin Med 2018 10;46(8):1727-1741. Epub 2018 Dec 10.

* The Second Clinical School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, P. R. China.

Cardio/cerebral-vascular diseases seriously threaten human health and are the leading cause of death. As such, there is great interest in identifying a potential mechanism that controls the development process of cardio/cerebral vascular diseases. Present studies demonstrate that inflammasomes play an important role in the process of ischemic cardio/cerebral vascular diseases (ICCVDs). Read More

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February 2019
1 Read

Ginsenoside Rg3 Decreases NHE1 Expression via Inhibiting EGF-EGFR-ERK1/2-HIF-1 Pathway in Hepatocellular Carcinoma: A Novel Antitumor Mechanism.

Am J Chin Med 2018 10;46(8):1915-1931. Epub 2018 Dec 10.

† Institute of Interventional Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, P. R. China.

Na /H exchanger 1 (NHE1) plays a vital role in the oncogenesis and development of hepatocellular carcinoma (HCC) and has been regarded as a promising target for the treatment of HCC. Ginsenoside Rg3 (Rg3), a bioactive ginseng compound, is suggested to possess pleiotropic antitumor effects on HCC. However, the underlying mechanisms of Rg3 suppressing HCC remain unclear. Read More

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February 2019
1 Read

Management of Diabetes Mellitus with Puerarin, a Natural Isoflavone From Pueraria lobata.

Am J Chin Med 2018 10;46(8):1771-1789. Epub 2018 Dec 10.

* Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563003, P. R. China.

Diabetes mellitus (DM) has become one of the most challenging public health problems globally. The increasing prevalence and mortality rates call for more effective therapeutic agents, especially for DM complications. Traditional herbs have a long clinical application history for DM treatment. Read More

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February 2019
2 Reads

Oriental Herbal Medicine for Neurological Disorders in Children: An Overview of Systematic Reviews.

Am J Chin Med 2018 6;46(8):1701-1726. Epub 2018 Dec 6.

* Department of Pediatrics of Korean Medicine, Kyung Hee University, Korean Medicine Hospital at Gangdong, Seoul 05278, Republic of Korea.

Oriental herbal medicine (OHM) has been widely used in pediatric neurological disorders and has attracted attention as a safe and effective treatment. We aim to summarize and evaluate the evidence for OHM in pediatric neurological disorders for evidence-based decision-making. Without language restrictions, up-to-date research data were obtained from nine electronic databases. Read More

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February 2019
13 Reads

A Systematic Review of the Medicinal Potential of Mulberry in Treating Diabetes Mellitus.

Am J Chin Med 2018 6;46(8):1743-1770. Epub 2018 Dec 6.

† School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, P. R. China.

Diabetes mellitus (DM) is a serious metabolic disorder which has reached epidemic proportions all over the world. Despite tremendous developments in medicinal chemistry, traditional medicine is still commonly used for the prevention and treatment of DM. Traditional herbal medicines have played a major role in the management of DM in Asian countries. Read More

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February 2019
2 Reads

Calotropis gigantea Promotes Neuritogenesis and Synaptogenesis through Activation of NGF-TrkA-Erk1/2 Signaling in Rat Hippocampal Neurons.

Am J Chin Med 2018 6;46(8):1861-1877. Epub 2018 Dec 6.

* Department of Anatomy, Dongguk University Graduate School of Medicine, Gyeongju 38066, Republic of Korea.

Calotropis gigantea (L.) R. Br (Apocynaceae) (commonly known as milkweed or crown flower) is a large shrub native to temperate regions of Asia, including China, Bangladesh and India and has a long history of use in traditional medicines. Read More

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February 2019
2 Reads

Fermented Red Ginseng Alleviates Cyclophosphamide-Induced Immunosuppression and 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis in Mice by Regulating Macrophage Activation and T Cell Differentiation.

Am J Chin Med 2018 6;46(8):1879-1897. Epub 2018 Dec 6.

* Neurobiota Research Center and Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea.

A variety of products have been developed with red ginseng (RG, the steamed roots of Panax ginseng Meyer). To clarify the immunomodulating effects of water-extracted RG (wRG), 50% ethanol-extracted RG (eRG), enzyme-treated eRG (ERG) and probiotic-fermented eRG (FRG), we examined their immunopotentiating and immunosuppressive effects in mice with cyclophosphamide (CP)-induced immunosuppression (CI) or 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis (TC). Oral administration of RG in CI mice significantly increased blood IFN- levels. Read More

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February 2019
15 Reads

M2 Polarization by Baicalin Enhances Efferocytosis via Upregulation of MERTK Receptor.

Am J Chin Med 2018 6;46(8):1899-1914. Epub 2018 Dec 6.

* Department of Biological Science and Technology, National Pingtung University of Science and Technology, 1, Shuefu Rd., Neipu, Pingtung 91201, Taiwan.

Baicalin is the main active ingredient primary isolated from the Chinese herb, Scutellaria baicalensis Georgi. Although baicalin can induce M2 macrophage polarization, we still do not know the subtype of macrophages polarized by baicalin. In this study, we characterized that murine bone marrow derived macrophages induced by M-CSF can be further polarized into M2 phenotype by baicalin. Read More

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February 2019
20 Reads

Recent Advances in Drug Delivery System for Bioactive Glycosides from Traditional Chinese Medicine.

Am J Chin Med 2018 27;46(8):1791-1824. Epub 2018 Nov 27.

* School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.

Traditional Chinese Medicine (TCM) has been used in China for thousands of years for the prevention and treatment of various diseases. The materials that exert a therapeutic effect are called the active ingredients. The bioactive glycosides are important active ingredients from TCM that can make significant contributions to treating diseases. Read More

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February 2019
2.625 Impact Factor

The Most Commonly Treated Acupuncture Indications in the United States: A Cross-Sectional Study.

Am J Chin Med 2018 Oct 9:1-33. Epub 2018 Oct 9.

∥ American TCM Society, New York City, New York, USA.

Acupuncture has been a popular alternative medicine in the United States for several decades. Its therapeutic effects on pain have been validated by both basic and clinical researches, and it is currently emerging as a unique non-pharmaceutical choice for pain against opioid crisis. However, the full spectrum of acupuncture indications remains unexplored. Read More

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October 2018
7 Reads
2.620 Impact Factor

Beneficial Effects of Korean Red Ginseng in the Progression of Non-Alcoholic Steatohepatitis via FABP4 Modulation.

Am J Chin Med 2018 Oct 9:1-27. Epub 2018 Oct 9.

1 Biosafety Research Institute and Laboratory of Pathology, (BK21 Plus Program), College of Veterinary Medicine, Chonbuk National University, Iksan, Republic of Korea.

Korean red ginseng (KRG) is a traditional herbal medicine used to prevent several geriatric diseases due to its therapeutic effects on metabolic disorder, including type 2 diabetes and fatty liver disease. In this study, we investigated the effects of KRG on the progression of nonalcoholic steatohepatitis (NASH) in mice. NASH was induced by feeding a methionine- and choline-deficient high-fat or high-fat/high-sucrose diet for 6 or 13 weeks, respectively. Read More

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October 2018
12 Reads

Acupuncture Application in Chronic Kidney Disease and its Potential Mechanisms.

Am J Chin Med 2018 ;46(6):1169-1185

* Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P. R. China.

Chronic kidney disease (CKD) is an increasing major public health problem worldwide. The number of CKD patients on hemodialysis is growing rapidly as well. Acupuncture technique is one of the traditional Chinese medicine methods and has been used in a variety of diseases. Read More

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December 2018
9 Reads

Marsdenia tenacissima: A Review of Traditional Uses, Phytochemistry and Pharmacology.

Am J Chin Med 2018 Oct 4:1-32. Epub 2018 Oct 4.

1 Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China.

The stems and roots of Marsdenia tenacissima (Roxb.) Wight et Arn., a traditional Chinese medicine and Dai herbal medicine, have been widely used for the treatment of asthma, trachitis, tonsillitis, pharyngitis, cystitis, pneumonia and drug or food poisoning. Read More

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October 2018
48 Reads

Regulating Gut Flora Dysbiosis in Obese Mice by Electroacupuncture.

Am J Chin Med 2018 Oct 4:1-17. Epub 2018 Oct 4.

* Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Liutai Road 1166, Wenjiang District, Chengdu 610037, P. R. China.

Recently, gut flora has been linked to the onset of obesity and has been shown to influence the host's metabolism. Acupuncture is a well-known agent used for the treatment of numerous diseases such as obesity. This study aimed to explore the impacts of electroacupuncture treatment on gut microbiota composition and function in obese mice. Read More

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October 2018
16 Reads