2,663 results match your criteria American Journal Of Chinese Medicine[Journal]


Tetramethylpyrazine Attenuated Sevoflurane-Induced Neurotoxicity by Enhancing Autophagy through GPR50/CREB Pathway in SH-SY5Y Cells.

Am J Chin Med 2020 May 30:1-22. Epub 2020 May 30.

Department of Anesthesiology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, P. R. China.

Tetramethylpyrazine has shown neuroprotective and axonal outgrowth-promoting effects and can improve cognitive deficit in a rat model of chronic hypoperfusion. However, the role of tetramethylpyrazine in sevoflurane-induced neurotoxicity is still vague. Therefore, this study was designed to investigate the effects and mechanisms of tetramethylpyrazine on sevoflurane-induced autophagy, apoptosis, and the expression of BACE1 and A[Formula: see text] in SH-SY5Y cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500457DOI Listing

Lancemaside A Isolated from the Root of Inhibits Ovarian Cancer Cell Invasion via the Reactive Oxygen Species (ROS)-Mediated p38 Pathway.

Am J Chin Med 2020 May 29:1-14. Epub 2020 May 29.

Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, South Korea.

roots have been widely used in Korean cuisine and traditional medicine. This study aimed to investigate the antimetastatic effects of lancemaside A, a major triterpenoid saponin, isolated from the roots of , in human ovarian cancer cells. Lancemaside A significantly suppressed the migration and invasion and the expression of matrix metalloproteinases (MMPs)-2 and -9 in ovarian cancer A2780 and SKOV3 cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500494DOI Listing

Intra-Pancreatic Insulin Nourishes Cancer Cells: Do Insulin-Receptor Antagonists such as PGG and EGCG Play a Role?

Am J Chin Med 2020 May 28:1-15. Epub 2020 May 28.

The Laboratory of Acute Abdomen Disease Associated, Organ Injury and Repair, Nankai Hospital Affiliated to Nankai University, Tianjin 300100, P. R. China.

Harboring insulin-producing cells, the pancreas has more interstitial insulin than any other organ. , insulin activates both insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) to stimulate pancreatic cancer cells. Whether intra-pancreatic insulin nourishes pancreatic cancer cells remains uncertain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500482DOI Listing

Variations of Oral Microbiome in Chronic Insomnia Patients with Different Tongue Features.

Am J Chin Med 2020 May 21:1-22. Epub 2020 May 21.

Chinese Medicine School, Beijing University of Chinese Medicine, Beijing 100029, P. R. China.

Chronic insomnia is a disease which brings intense mental pain and disturbing complications to patients worldwide. The oral microbiome exhibits a mechanistic influence on human health. Therefore, it is crucial to understand the oral microbial diversity in insomnia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500445DOI Listing

Preventive Effects of on Cerulein-Induced Chronic Pancreatitis.

Am J Chin Med 2020 May 20:1-17. Epub 2020 May 20.

Department of Herbology, Wonkwang University School of Korean Medicine, Iksan 54538, Republic of Korea.

Our previous report revealed that (GJ) has protective effects against acute pancreatitis. So, we examined whether aqueous extract of GJ has anti-inflammation and antifibrotic effects even against cerulein-induced chronic pancreatitis (CP). CP was induced in mice by an intraperitoneal injection of a stable cholecystokinin (CCK) analogue, cerulein, six times a day, four days per week for three weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500470DOI Listing

L.: A Comprehensive Review of its Botany, Phytochemistry and Pharmacology.

Am J Chin Med 2020 May 20:1-27. Epub 2020 May 20.

School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530200, P. R. China.

L. ( L.), a member of the Compositae family, is a perennial plant that has been used as a traditional medicine for more than 2000 years in China and is widely used for the treatment of Pemphigus, swelling, pain, and scrofula. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500421DOI Listing

The Application of Fermentation Technology in Traditional Chinese Medicine: A Review.

Am J Chin Med 2020 May 20:1-23. Epub 2020 May 20.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P. R. China.

In Chinese medicine, fermentation is a highly important processing technology whereby medicinal herbs are fermented under appropriate temperature, humidity, and moisture conditions by means of the action of microorganisms to enhance their original characteristics and/or produce new effects. This expands the scope of such medicines and helps them to meet the stringent demands of clinical application. Since ancient times, Chinese medicine has been made into Yaoqu to reduce its toxicity and increase its efficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500433DOI Listing
May 2020
2.625 Impact Factor

Ginsenoside Rb2 Ameliorates LPS-Induced Inflammation and ER Stress in HUVECs and THP-1 Cells via the AMPK-Mediated Pathway.

Am J Chin Med 2020 May 20:1-19. Epub 2020 May 20.

Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.

Inflammation and endoplasmic reticulum (ER) stress have been documented to contribute to the development of atherosclerosis. Ginsenoside Rb2 has been reported to exhibit antidiabetic effects. However, the effects of Rb2 on atherosclerotic responses such as inflammation and ER stress in endothelial cells and monocytes remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500469DOI Listing

Acupuncture for Pain Management: Molecular Mechanisms of Action.

Am J Chin Med 2020 May 15:1-19. Epub 2020 May 15.

Department of Integrative Medicine and Neurobiology Institutes of Integrative Medicine School of Basic Medical Sciences Institutes of Brain Science, Brain Science Collaborative Innovation Center State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan University Shanghai, P. R. China.

Acupuncture reduces pain by activating specific areas called acupoints on the patient's body. When these acupoints are fully activated, sensations of soreness, numbness, fullness, or heaviness called De qi or Te qi are felt by clinicians and patients. There are two kinds of acupuncture, manual acupuncture and electroacupuncture (EA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500408DOI Listing

Evaluation of the Adjuvant Efficacy of Natural Herbal Medicine on COVID-19: A Retrospective Matched Case-Control Study.

Am J Chin Med 2020 May 15:1-14. Epub 2020 May 15.

Department of Infectious Disease, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, P. R. China.

Since the outbreak of Corona Virus Disease 2019 (COVID-19) in Hubei province, the epidemic scale has increased rapidly, and no effective antiviral drug therapy has been identified yet. This study aimed to evaluate the adjuvant efficacy of Natural Herbal Medicine (NHM) combined with Western medicine in the treatment of COVID-19. We performed a retrospective, 1:1 matched, case-control study of the first cohort of hospitalized COVID-19-confirmed cases (January 17, 2020 to January 28, 2020). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500391DOI Listing

Efficacy and Safety of in Patients with Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.

Am J Chin Med 2020 30;48(3):513-534. Epub 2020 Apr 30.

School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Selangor, Malaysia.

and its extract have been suggested to have a neuroprotective role in patients with acute ischemic stroke. We aimed to examine the efficacy and safety of use in patients with acute ischemic stroke. We searched seven databases for randomized controlled studies examining the use of in patients with acute ischemic stroke. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500263DOI Listing

Cinobufagin Triggers Defects in Spindle Formation and Cap-Dependent Translation in Liver Cancer Cells by Inhibiting the AURKA-mTOR-eIF4E Axis.

Am J Chin Med 2020 30;48(3):651-678. Epub 2020 Apr 30.

Central Laboratory, Logistics University of Chinese People's Armed Police Force, Tianjin City 300309, P. R. China.

Cinobufagin is a Na/K-ATPase (NKA) inhibitor with excellent anticancer effects to prolong the survival of patients. The purpose of the present study was to clarify the underlying mechanism of the anticancer effects of cinobufagin using overexpression or inhibition of aurora kinase A (AURKA) signaling. First, high expression of Na/K-ATPase alpha 1 subunit (ATP1A1) and AURAK resulted in increased malignant transformation in hepatocellular carcinoma (HCC) patients using the cancer genome atlas (TCGA) data and tissue samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500330DOI Listing

Becoming a Faithful Defender: Traditional Chinese Medicine against Coronavirus Disease 2019 (COVID-19).

Am J Chin Med 2020 Apr 29:1-15. Epub 2020 Apr 29.

The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, P. R. China.

The outbreak caused by COVID-19 is causing a major challenge to clinical management and a worldwide threat to public health. So far, there is no specific anti-coronavirus therapy approved for the treatment of COVID-19. Recently, as the efficacy and safety of traditional Chinese medicine (TCM) is widely acknowledged, it has been brought to a crucial status by the public, governments, and World Health Organization (WHO). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X2050038XDOI Listing

Partitioned Extracts of Induce G/G Phase Arrest and Apoptosis in Human Colon Cancer Cells.

Am J Chin Med 2020 29;48(3):719-736. Epub 2020 Apr 29.

Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan.

(Benth.) is one of the commonly used herbs in Taiwan. The stem of this plant has been used to treat epigastria pain and rheumatoid arthritis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500366DOI Listing

A Review of Medicinal Plants in Cardiovascular Disorders: Benefits and Risks.

Am J Chin Med 2020 ;48(2):259-286

Department of Human Anatomy, Medical College of Qinghai University, Xining 810000, Qinghai Province, P. R. China.

Many cultivated and wild plants are used for the management of various diseases, specifically renal and hepatic diseases and those of the immune and cardiovascular systems. In China, medicinal plants from ancient to modern history have been used in patients with angina pectoris, congestive heart failure (CHF), systolic hypertension, arrhythmia, and venous insufficiency for centuries. The latest increase in the fame of natural products and alternative medicine has revived interest in conventional remedies that have been consumed in the management of CVD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500147DOI Listing
January 2020
2.625 Impact Factor

The Role of Th17/Treg Axis in the Traditional Chinese Medicine Intervention on Immune-Mediated Inflammatory Diseases: A Systematic Review.

Am J Chin Med 2020 29;48(3):535-558. Epub 2020 Apr 29.

The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.

The Th17/Treg axis plays a crucial role in immune-mediated inflammatory diseases (IMID) and might represent an interesting drug target of treatment strategy for these diseases. Accumulating evidence suggests a role for traditional Chinese medicine (TCM) in the modulation of Th17/Treg axis, but a comprehensive overview which summarizes this field hitherto is lacked. This paper performs a systematic literature review of the regulatory effects of TCM on the imbalance of Th17/Treg axis and its potential mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500275DOI Listing

Muscone Ameliorates LPS-Induced Depressive-Like Behaviors and Inhibits Neuroinflammation in Prefrontal Cortex of Mice.

Am J Chin Med 2020 29;48(3):559-577. Epub 2020 Apr 29.

Spine Disease Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P. R. China.

Depression is partially caused by inflammation in the central nervous system. Early study demonstrated that musk, glandular secretion from male musk deer, exerted an antidepressant-like effect. The aim of this study was to investigate if muscone, a bioactive ingredient in musk, could ameliorate neuroinflammation and depressive-like behaviors as well as explore the potential action mechanism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500287DOI Listing

Traditional Chinese Medicine for Alzheimer's Disease and Other Cognitive Impairment: A Review.

Am J Chin Med 2020 24;48(3):487-511. Epub 2020 Apr 24.

Institude of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, P. R. China.

Cognitive impairment (CI) refers to the dysfunction of memory, language, visual space, execution, calculation, understanding, and judgment in one or more aspects. With global aging, CI will become prevalent worldwide. At present, there is no effective cure for CI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500251DOI Listing

Naringin Induces Lysosomal Permeabilization and Autophagy Cell Death in AGS Gastric Cancer Cells.

Am J Chin Med 2020 24;48(3):679-702. Epub 2020 Apr 24.

Research Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University, Gazwa, Jinju 52828, Republic of Korea.

Autophagy is a process of active programmed cell death, where a dying cell induces autophagosomes and subsequently regulated by degradative machinery. The aim of this study was to investigate the mechanism behind induction of autophagic cell death by Naringin flavonoid in AGS cancer cells. Growth inhibition of AGS cells showed downregulation of PI3K/Akt/mTOR signaling by Naringin treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500342DOI Listing

Corosolic Acid Attenuates Hepatic Lipid Accumulation and Inflammatory Response via AMPK/SREBPs and NF-B/MAPK Signaling Pathways.

Am J Chin Med 2020 24;48(3):579-595. Epub 2020 Apr 24.

Key Laboratory of Natural Resources of Changbai, Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, Jilin Province, P. R. China.

Corosolic acid (CA) is the main active component of and has been known to serve as several different pharmacological effects, such as antidiabetic, anti-oxidant, and anticancer effects. In this study, effects of CA on the hepatic lipid accumulation were examined using HepG2 cells and tyloxapol (TY)-induced hyperlipidemia ICR mice. CA significantly inhibited hepatic lipid accumulation via inhibition of SREBPs, and its target genes FAS, SCD1, and HMGCR transcription in HepG2 cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500299DOI Listing

Cinobufacini Inhibits Colon Cancer Invasion and Metastasis via Suppressing Wnt/β-Catenin Signaling Pathway and EMT.

Am J Chin Med 2020 24;48(3):703-718. Epub 2020 Apr 24.

Department Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P. R. China.

Cinobufacini is a well-known Chinese medicine extracted from Venenum Bufonis, also called Chan Su. It has been used clinically for various cancers, including colon cancer. However, the function of Cinobufacini on colon cancer invasion and metastasis, and its underlying molecular mechanism, is still not clear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500354DOI Listing

Seed Improves Pancreatic Mitochondrial Function Leading to Recovery of Glucose Metabolism.

Am J Chin Med 2020 24;48(3):615-629. Epub 2020 Apr 24.

Interdisciplinary Program of Bioenergy and Biomaterials, Graduate School, College of Engineering, College of Engineering, Chonnam National University, Gwangju 61186, Republic of Korea.

Mitochondrial metabolism plays a crucial role in insulin resistance and insulin secretion in type 2 diabetes mellitus (T2D). Some studies have focused on how extracts affect insulin resistance and hyperglycemia. However, the effects of extracts on mitochondrial dysfunction associated with insulin secretion have not been well explained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500317DOI Listing

BST204, a Rg3 and Rh2 Enriched Ginseng Extract, Upregulates Myotube Formation and Mitochondrial Function in TNF-α-Induced Atrophic Myotubes.

Am J Chin Med 2020 24;48(3):631-650. Epub 2020 Apr 24.

Research Institute of Pharmaceutical Science, College of Pharmacy, Sookmyung Women's University, Seoul 04310, Republic of Korea.

The loss of skeletal muscle mass and function is a serious consequence of chronic diseases and aging. BST204 is a purified ginseng (the root of ) extract that has been processed using ginsenoside--glucosidase and acid hydrolysis to enrich ginsenosides Rg3 and Rh2 from the crude ginseng. BST204 has a broad range of health benefits, but its effects and mechanism on muscle atrophy are currently unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500329DOI Listing

Magnoliae Flos Essential Oil as an Immunosuppressant in Dendritic Cell Activation and Contact Hypersensitivity Responses.

Am J Chin Med 2020 17;48(3):597-613. Epub 2020 Apr 17.

Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, National Cheng Kung University, Tainan, Taiwan.

Magnoliae Flos is a commonly used traditional medicinal material in Asia. It is used to treat sinusitis, nasal congestion, and hypersensitive skin. Because Magonlia Flos was described as an aromatic material in ancient Chinese texts, we hypothesized that its essential oil may be used to treat immune disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500305DOI Listing

COVID-19: An Update on the Epidemiological, Clinical, Preventive and Therapeutic Evidence and Guidelines of Integrative Chinese-Western Medicine for the Management of 2019 Novel Coronavirus Disease.

Am J Chin Med 2020 13;48(3):737-762. Epub 2020 Mar 13.

Department of Medicine, The University of Hong Kong, Hong Kong.

As of 22 February 2020, more than 77662 cases of confirmed COVID-19 have been documented globally with over 2360 deaths. Common presentations of confirmed cases include fever, fatigue, dry cough, upper airway congestion, sputum production, shortness of breath, myalgia/arthralgia with lymphopenia, prolonged prothrombin time, elevated C-reactive protein, and elevated lactate dehydrogenase. The reported severe/critical case ratio is approximately 7-10% and median time to intensive care admission is 9. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500378DOI Listing
May 2020
2.625 Impact Factor

Chemical Constituents and Pharmacological Activities of Family Flacourtiaceae: A Class of Important Phytomedicine.

Am J Chin Med 2020 11;48(2):287-328. Epub 2020 Mar 11.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China.

Flacourtiaceae plants are widely used as folk medicines in traditional medicine systems for its chemical diversity and pharmacological activities. In many different areas, Flacourtiaceae plants are used as traditional medicines for the treatment of ulcers, malaria, rheumatism. The Flacourtiaceae plants contain a very plentiful chemical composition, and phytochemical studies show that the Flacourtiaceae plants contained terpenoids, aromatic glycosides, flavnoids, phenylpropanoids, alkaloids, fatty hydrocarbon, and other compounds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500159DOI Listing
March 2020
2.625 Impact Factor

Exerts Anti-Inflammatory Effects by Targeting PDK1 in the NF-B Pathway.

Am J Chin Med 2020 11;48(2):429-444. Epub 2020 Mar 11.

Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea.

Pharmacological activities of some Leguminosae family members were reported. Pharmacological activities of , a Leguminosae family member have never been explored. Therefore, this study investigated anti-inflammatory effects of an methanol extract (Al-ME). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500226DOI Listing

(-)-Epigallocatechin Gallate Promotes MicroRNA 145 Expression against Myocardial Hypoxic Injury through Dab2/Wnt3a/-catenin.

Am J Chin Med 2020 5;48(2):341-356. Epub 2020 Mar 5.

Department of Emergency Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

MicroRNA 145 (miR-145) is a critical modulator of cardiovascular diseases. The downregulation of myocardial miR-145 is followed by an increase in disabled-2 (Dab2) expression in cardiomyocytes. (-)-epigallocatechin gallate (EGCG) is a flavonoid that has been evaluated extensively due to its diverse pharmacological properties including anti-inflammatory effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500172DOI Listing

Neuroprotective Effect of in D-Galactose-Induced Aging Model.

Am J Chin Med 2020 5;48(2):373-390. Epub 2020 Mar 5.

Department of Physical Therapy, Asia University, Taichung, Taiwan.

The medicinal plant grows at high altitudes in the Arctic and mountainous regions and is commonly used in phytotherapy in Eastern European and Asian countries. In the present study, we investigated the anti-apoptotic effect of and its neuroprotective mechanism of action in a rat model of D-galactose-induced aging. Two groups of twelve-week-old male Wistar rats received a daily injection of D-galactose (150mg/kg/day, i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500196DOI Listing

Research Advances on Acupuncture Analgesia.

Am J Chin Med 2020 5;48(2):245-258. Epub 2020 Mar 5.

School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China.

Pain is a widespread and complex symptom which causes serious emotional and social burdens to individuals and society. Most patients with pain rely heavily on over the counter (OTC) and prescription pain killers. However, there would be a number of issues that arise from the use of pain killers, in which safety and addiction are the most critical issues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500135DOI Listing

Anti-Apoptotic Effects of Diosgenin in D-Galactose-Induced Aging Brain.

Am J Chin Med 2020 5;48(2):391-406. Epub 2020 Mar 5.

Department of Physical Therapy, Asia University, Taichung, Taiwan.

The purpose of this study was to evaluate the effects of diosgenin on the D-galactose-induced cerebral cortical widely dispersed apoptosis. Male 12-week-old Wistar rats were divided into four groups: Control (1mg/kg/day of saline, i.p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500202DOI Listing
March 2020
2.625 Impact Factor

Alkaloids Attenuate Cisplatin-Induced Neuropathic Pain by Reducing Loss of IENF and Blocking TRPV1 Activation.

Am J Chin Med 2020 5;48(2):407-428. Epub 2020 Mar 5.

Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, P. R. China.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication of cisplatin, which is characterized by intolerable paresthesia, burning, and hyperalgesia, and severely impacts the life quality of patients. However, no clearly potent drug has been found for clinical medication due to its undefined mechanism. , a traditional Chinese medicine, has been proven to work well in anti-inflammation, blood circulations improvement, hemostasis, and analgesia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500214DOI Listing

Chuanxiong (Rhizome of ) Protects Ovariectomized Hyperlipidemic Rats from Bone Loss.

Am J Chin Med 2020 5;48(2):463-485. Epub 2020 Mar 5.

State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), Shenzhen, China.

Oxidative stress (OS) is the common mechanism for age-related diseases. The co-occurrence of osteoporosis (OP) and cardiovascular disease (CVD) in postmenopausal women makes it warranted to find a holistic approach for treatment of multiple diseases or conditions. The rhizome of Hort. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X2050024XDOI Listing

Wigg. Attenuates Inflammatory Responses in Murine Microglia through the Nrf2/HO-1 and NF-B Signaling Pathways.

Am J Chin Med 2020 5;48(2):445-462. Epub 2020 Mar 5.

Department of Pharmacy, Qingdao University of Science and Technology, Qingdao, China.

As a long-established medicinal and edible homologous plant, Wigg. is widely distributed in Asia, Europe, and other parts of the world. is reported to exert a variety of biological and pharmacological activities, including anticancer, hepatoprotective, and anti-obesity effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500238DOI Listing
March 2020
2.625 Impact Factor

Effects of Chinese and Western Medicine on Patients with Dengue Fever.

Am J Chin Med 2020 5;48(2):329-340. Epub 2020 Mar 5.

Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and School of Traditional Chinese Medicine, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Dengue fever is an important epidemic disease with a high prevalence in tropical and subtropical countries. We aimed to investigate the effects of a treatment integrating traditional Chinese (TCM) and Western medicines on dengue inpatients with warning signs (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500160DOI Listing
March 2020
2.625 Impact Factor

Induces Thrombomodulin Expression and Tissue-Type Plasminogen Activator Secretion via the Activation of Krüppel-Like Factor 2 within Endothelial Cells.

Am J Chin Med 2020 28;48(2):357-372. Epub 2020 Feb 28.

Division of Cardiology, Department of Internal Medicine, Hualien Armed Forces General Hospital, Hualien County 971, Taiwan, R.O.C.

The effects of thrombo-prevention, such as antiplatelet and anticoagulant activity, have been reported with the usage of Ginkgo biloba extract (GbE); however, the detailed mechanism has not yet been fully investigated, especially the role of Krüppel-like factor 2 (KLF2). This study aimed to investigate whether GbE can activate KLF2 and then induce thrombomodulin (TM) and tissue-type plasminogen activator (t-PA) secretion to enhance the effects of thrombo-prevention. Different concentrations of GbE were incubated with human umbilical vein endothelial cells (HUVECs) to evaluate its effect on endothelial cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500184DOI Listing
February 2020

Glycyrrhizic Acid Modulates Apoptosis through Extrinsic/Intrinsic Pathways and Inhibits Protein Kinase B- and Extracellular Signal-Regulated Kinase-Mediated Metastatic Potential in Hepatocellular Carcinoma and .

Am J Chin Med 2020 ;48(1):223-244

Department of Radiation Oncology, Show Chwan Memorial Hospital, Changhua 505, Taiwan, R.O.C.

A previous study presented that glycyrrhizic acid as the hepatoprotective agent inhibits total parenteral nutrition-associated acute liver injury in rats. However, the anticancer effect and mechanism of glycyrrhizic acid in human hepatocellular carcinoma (HCC) is ambiguous. The purpose of the present study was to investigate the effect of glycyrrhizic acid on apoptosis dysregulation and metastatic potential in HCC and . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500123DOI Listing
January 2020

Effects of Herbal Medicines on Pain Management.

Am J Chin Med 2020 ;48(1):1-16

Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA.

Pain is an unpleasant sensory and emotional experience in many diseases and is often caused by intense or damaging stimuli. Pain negatively affects the quality of life and increases high health expenditures. Drugs with analgesic properties are commonly used to relieve pain, but these Western medications could be overwhelmed by side effects including tolerance and addiction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500019DOI Listing
January 2020

A Review of Traditional Uses, Phytochemistry, and Pharmacological Properties of the Genus .

Am J Chin Med 2020 21;48(1):47-76. Epub 2020 Jan 21.

Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource, Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 710062, P. R. China.

The genus , belonging to Saururaceae, contains two species, L. and (Lour) Baill. with common utilization in traditional medicine from Asia to North America for the treatment of edema, beriberi, jaundice, leucorrhea, urinary tract infections, hypertension, hepatitis diseases, and tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500032DOI Listing
January 2020
2.625 Impact Factor

Integrating Network Pharmacology and Experimental Models to Investigate the Efficacy of Coptidis and Scutellaria Containing Huanglian Jiedu Decoction on Hepatocellular Carcinoma.

Am J Chin Med 2020 21;48(1):161-182. Epub 2020 Jan 21.

School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Unlike Western medicines with single-target, the traditional Chinese medicines (TCM) always exhibit diverse curative effects against multiple diseases through its "multi-components" and "multi-targets" manifestations. However, discovery and identification of the major therapeutic diseases and the underlying molecular mechanisms of TCM remain to be challenged. In the current study, we, for the first time, applied an integrated strategy by combining network pharmacology with experimental evaluation, for exploration and demonstration of the therapeutic potentials and the underlying possible mechanisms of a classic TCM formula, Huanglian Jiedu decoction (HLJDD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500093DOI Listing
January 2020
2.625 Impact Factor

A Comprehensive Review for Phytochemical, Pharmacological, and Biosynthesis Studies on spp.

Am J Chin Med 2020 14;48(1):17-45. Epub 2020 Jan 14.

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China.

Licorice is extensively applied in food as well as herbal medicine across the world, possessing a substantial share in the global market. It has made great progress in chemical and pharmacological research in recent years. Currently, Fisch. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500020DOI Listing
January 2020

Suppresses High Glucose-Induced Matrix Metalloproteinase Expression and Inflammatory Responses by Inhibiting ROS-Related HMGB1-TLR4 Signaling in Endothelial Cells.

Am J Chin Med 2020 14;48(1):91-105. Epub 2020 Jan 14.

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.

, a popular folk medicine for anti-altitude sickness in Tibet, has been shown to have protective effects against high glucose (HG)-induced endothelial cell dysfunction in human umbilical vein endothelial cells (HUVECs). However, its mechanisms of action are unclear. Here, we aimed to examine the effects and the mechanisms of action of extract (RCE) on matrix metalloproteinases (MMPs) and inflammatory responses under HG conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500056DOI Listing
January 2020

Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-B Pathway.

Am J Chin Med 2020 14;48(1):127-142. Epub 2020 Jan 14.

College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan 410128, P. R. China.

(), a traditional Chinese medicine, has great potential as an effective growth promoter in animals, however, the mechanism of its actin remains unclear. Here, we evaluated the protective effects of koumine extract from against lipopolysaccharide (LPS)-induced intestinal barrier dysfunction in IPEC-J2 cells through alleviation of inflammation and oxidative stress. MTT and LDH assays revealed that koumine significantly reduced LPS cytotoxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X2050007XDOI Listing
January 2020
2.625 Impact Factor

Chinese Medicine , Containing , and , Protects from Myocardial Ischemia Injury via Angiogenesis.

Am J Chin Med 2020 14;48(1):107-126. Epub 2020 Jan 14.

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. China.

The Chinese patent medicine (SXXTN) is a clinical medication for coronary heart disease (CHD) and angina pectoris. This study aimed to investigate pharmacological effects of SXXTN and elucidate the role in angiogenesis on human umbilical vein endothelial cells (HUVECs) and acute myocardial ischemia (AMI) rats. We prepared SXXTN to treat the cells to reveal their effects on oxidative stress-damaged cell viability, as well as cell proliferation, migration, and tube formation processes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500068DOI Listing
January 2020

Electroacupuncture Relieves Irritable Bowel Syndrome by Regulating IL-18 and Gut Microbial Dysbiosis in a Trinitrobenzene Sulfonic Acid-Induced Post-Inflammatory Animal Model.

Am J Chin Med 2020 10;48(1):77-90. Epub 2020 Jan 10.

Department of Acupuncture, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu 210029, P. R. China.

Post inflammatory irritable bowel syndrome (PI-IBS), a subset of IBS, is characterized by symptoms of visceral pain, bloating, and changed bowel habits that occur post initial episode of intestinal infection. Gut microbial dysbiosis or inflammation plays a key role in the pathogenesis of abdominal hypersensitivity of PI-IBS. Electroacupuncture (EA) stimulation results in an alleviated PI-IBS-associated symptom. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500044DOI Listing
January 2020

Isoorientin Decreases Cell Migration via Decreasing Functional Activity and Molecular Expression of Proton-Linked Monocarboxylate Transporters in Human Lung Cancer Cells.

Am J Chin Med 2020 10;48(1):201-222. Epub 2020 Jan 10.

Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.

Aggressive tumor cells mainly rely on glycolysis, and further release vast amounts of lactate and protons by monocarboxylate transporter (MCT), which causes a higher intracellular pH (pH) and acidic extracellular pH. Isoorientin, a principle flavonoid compound extracted from several plant species, shows various pharmacological activities. However, effects of isoorientin on anticancer and MCT await to explore in human lung cancer cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500111DOI Listing
January 2020

Baicalin Inhibits Coxsackievirus B3 Replication by Reducing Cellular Lipid Synthesis.

Am J Chin Med 2020 6;48(1):143-160. Epub 2020 Jan 6.

Department of Endocrinology, The First Affiliated Hospital of Soochow University, 188 Shizhi Street, Suzhou, Jiangsu 215006, P. R. China.

Baicalin is a flavonoid extracted from and shows a variety of biological activities as reducing lipids, diminishing inflammation, and inhibiting bacterial infection. However, there is no report of baicalin against CVB3 infection. In this study, we found that baicalin can reduce viral titer in a dose-dependent manner at a dose with no direct virucidal effect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X20500081DOI Listing
January 2020

Erianin Induces Apoptosis and Autophagy in Oral Squamous Cell Carcinoma Cells.

Am J Chin Med 2020 6;48(1):183-200. Epub 2020 Jan 6.

Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan.

Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide. It has a very poor prognosis with over a 5-year survival rate of only 50%. Thus, it is important to identify effective therapeutic interventions against oral cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X2050010XDOI Listing
January 2020

Leaves Prevent NMU-Induced Mammary Tumor through Downregulation of Fatty Acid Synthase, Estrogen Receptor-α and Her2 Expression.

Am J Chin Med 2019 ;47(8):1885-1899

Department of Health Diet and Industry Management, Chung Shan Medical University, Taichung City 40201, Taiwan.

Diet polyphenol can reportedly prevent the formation of breast-cancer cells. Nelumbo nucifera leaf extract (NLE) is enriched with polyphenols and has several cellular functions, such as anti-atherosclerosis, anti-inflammation, and antitumor. In this study, we investigated the role of NLE in the prevention of N-methyl-N-nitrosourea (NMU)-induced mammary tumor formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X19500964DOI Listing

The Neuroimmune Basis of Acupuncture: Correlation of Cutaneous Mast Cell Distribution with Acupuncture Systems in Human.

Authors:
Yong Ming Li

Am J Chin Med 2019 5;47(8):1781-1793. Epub 2019 Dec 5.

Dermatopathology Service, Bridgewater, NJ, USA.

The hypothesis that cutaneous mast cells (MCs) are responsible for skin phenomena in acupuncture was proposed 40 years ago, but very little is known about the correlation of MC distribution with acupuncture systems in human. The aim of this study is to quantify cutaneous mast cells at different body sites and compare them with the distributions of classical acupuncture points and micro-acupuncture systems. Skin biopsies from dermatological practice were evaluated under microscope with H&E or CD117 stains. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X19500903DOI Listing