2,853 results match your criteria American Journal Of Chinese Medicine[Journal]


Salidroside Ameliorates Ischemia-Induced Neuronal Injury through AMPK Dependent and Independent Pathways to Maintain Mitochondrial Quality Control.

Am J Chin Med 2022 May 5:1-21. Epub 2022 May 5.

Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P. R. China.

Salidroside, an active ingredient in , has potent protective activity against cerebral ischemia. However, the mechanisms underlying its pharmacological actions are poorly understood. In this study, we employed a mouse middle cerebral artery occlusion (MCAO) and cellular oxygen and glucose deprivation (OGD) models to test the hypothesis that salidroside may restore mitochondrial quality control in neurons by modulating the relevant signaling. Read More

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Mechanisms of Danggui Buxue Tang on Hematopoiesis via Multiple Targets and Multiple Components: Metabonomics Combined with Database Mining Technology.

Am J Chin Med 2022 Apr 26:1-17. Epub 2022 Apr 26.

School of Bioscience and Biopharmaceutics, Guangdong Province Key Laboratory for Biotechnology Drug Candidates, P. R. China.

This study aimed to explore the mechanism of action of Danggui Buxue Tang (DBT) with its multiple components and targets in the synergistic regulation of hematopoiesis. Mouse models of hematopoiesis were established using antibiotics. Metabolomics was used to detect body metabolites and enriched pathways. Read More

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Gut Flora Mediates the Rapid Tolerance of Electroacupuncture on Ischemic Stroke by Activating Melatonin Receptor through Regulating Indole-3-Propionic Acid.

Am J Chin Med 2022 Apr 26:1-28. Epub 2022 Apr 26.

Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, P. R. China.

Electroacupuncture (EA) is commonly used to treat cerebrovascular diseases. This study aimed to clarify the mechanisms of action of treatments of cerebral ischemic stroke from the perspective of gut microecology. We used a mouse model and cell cultures to investigate the effects of EA on the intestinal microflora in mice models of middle cerebral artery occlusion (MCAO) and the mechanisms underlying the antioxidant activities of metabolites. Read More

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Efficacy and Safety of Chinese Herbal Medicine for Endometriosis Associated Pain.

Am J Chin Med 2022 Apr 26:1-17. Epub 2022 Apr 26.

Department of Gynecology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China.

Endometriosis is a chronic, estrogen-dependent condition that causes dysmenorrhea and pelvic pain. Chinese herbal medicine (CHM) has been used for endometriosis for many years in Asian populations. This is a retrospective study in a territory teaching hospital of the China Academy of Chinese Medical Sciences in Beijing, China to compare the short- and long-term effectiveness and safety of CHM for endometriosis associated pain (EAP) before and after CHM treatment. Read More

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Protective Effect of Ginsenosides from Stems and Leaves of against Scopolamine-Induced Memory Damage via Multiple Molecular Mechanisms.

Am J Chin Med 2022 Apr 26:1-19. Epub 2022 Apr 26.

College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, P. R. China.

Although growing evidence has shown that ginsenosides from stems and leaves of (GSLS) exercise a protective impact on the central nervous system, in the model of memory damage induced by scopolamine, it is still rarely reported. Thus, the mechanism of action needs to be further explored. This study was to investigate the effect of GSLS on scopolamine (SCOP)-induced memory damage and the underlying mechanism. Read More

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Clinical Efficacy and Safety of Chinese Patent Medicine Combined with Oseltamivir for the Treatment of Adult Influenza: A Systematic Review and Meta-Analysis.

Am J Chin Med 2022 Apr 26:1-19. Epub 2022 Apr 26.

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing 100700, P. R. China.

Influenza is a sudden and serious viral breathing and lung-related infectious disease that causes significant deadliness and death worldwide. Now, the international treatment is oseltamivir. Chinese patent medicine (CPM) as a kind of different therapy is used in the treatment of influenza in China. Read More

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Polyphenols from Chinese Herbal Medicine: Molecular Mechanisms and Therapeutic Targets in Pulmonary Fibrosis.

Am J Chin Med 2022 Apr 26:1-32. Epub 2022 Apr 26.

State Key Laboratory of Natural Medicines, P. R. China.

Pulmonary fibrosis (PF) is a highly confounding and fatal pathological process with finite treatment options. Multiple factors such as oxidative and immune/inflammation involve key pathological processes in chronic lung disease, and their intimate interactions mediate chronic lung damage, denudation of the alveolar epithelium, hyperproliferation of type II alveolar epithelial cells (AECIIs), proliferation and differentiation of fibroblasts, and the permeability of microvessels. We reviewed the classic mechanism of PF and highlighted a few emerging mechanisms for studying complex networks in lung disease pathology. Read More

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Protective Effects and Therapeutics of Ginsenosides for Improving Endothelial Dysfunction: From Therapeutic Potentials, Pharmaceutical Developments to Clinical Trials.

Am J Chin Med 2022 13;50(3):749-772. Epub 2022 Apr 13.

College of Chemistry, Fuzhou University, Fuzhou 350116, China.

The endothelium covers the internal lumen of the entire circulatory system and plays an important modulatory role in vascular homeostasis. Endothelium dysfunction, characterized by a vasoconstrictive, pro-inflammatory, and pro-coagulant state, usually manifests as a significant pathological process of vascular diseases, including hypertension, atherosclerosis (AS), stroke, diabetes mellitus, coronary artery disease, and cancer. Therefore, there is an urgent necessity to seek promising therapeutic drugs or remedies to ameliorate endothelial dysfunction-induced vascular ailments and complications. Read More

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A Clinical Study on the Relationship Among Insomnia, Tongue Diagnosis, and Oral Microbiome.

Am J Chin Med 2022 4;50(3):773-797. Epub 2022 Apr 4.

Department of Rehabilitation Medicine of Korean Medicine, Dongguk University Goyang, Republic of Korea.

Currently, there is a lack of adequate methods to assess insomnia objectively. This study addresses the usefulness of tongue features and oral microbial profile as a potential diagnostic biomarker of insomnia. One hundred insomniac patients and 20 healthy control subjects were selected. Read More

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Herbal Medicines for Constipation and Phytochemical Comparison of Active Components.

Am J Chin Med 2022 24;50(3):723-732. Epub 2022 Mar 24.

Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA.

Constipation is a very common medical condition worldwide, negatively affecting patients' quality of life and healthcare system. Rhubarb, senna leaf, and aloe are three frequently used herbal medications for achieving regular bowel movement. Rhubarb is also a key ingredient in MaZiRenWan, a Chinese medicine formula used every so often for constipation in oriental countries. Read More

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Identifying Dose Components of Manual Acupuncture to Determine the Dose-Response Relationship of Acupuncture Treatment: A Systematic Review.

Am J Chin Med 2022 16;50(3):653-671. Epub 2022 Mar 16.

Acupuncture and Meridian Science Research Center, College of Korean Medicine Kyung Hee University, Seoul 02447, Republic of Korea.

The dose-response relationship is a hallmark of pharmacological studies. However, this relationship has not been fully established in acupuncture research. This systematic review aims to provide the characteristics of the dose-response relationship in acupuncture research. Read More

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Hydroxysafflor Yellow A Alleviates Ischemic Stroke in Rats via HIF-1[Formula: see text], BNIP3, and Notch1-Mediated Inhibition of Autophagy.

Am J Chin Med 2022 16;50(3):799-815. Epub 2022 Mar 16.

College of Traditional Chinese Medicine, Hebei University, Baoding, Hebei 071000, P. R. China.

Stroke has become a major cause of death and disability worldwide. The cellular recycling pathway autophagy has been implicated in ischemia-induced neuronal changes, but whether autophagy plays a beneficial or detrimental role is controversial. Hydroxysafflor Yellow A (HSYA), a popular herbal medicine, is an extract of Carthamus tinctorius and is used to treat ischemic stroke (IS) in China. Read More

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Effects of Capsaicin on the Hypoglycemic Regulation of Metformin and Gut Microbiota Profiles in Type 2 Diabetic Rats.

Am J Chin Med 2022 16;50(3):839-861. Epub 2022 Mar 16.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.

Dietary capsaicin (CAP), the main irritant component in pepper, can reduce the incidence of diabetes, while metformin (MET) is a first-line oral hypoglycemic drug. The purpose of this study was to investigate whether CAP on the hypoglycemic effect of MET is pertinent to gut microbiota. The glucose and insulin tolerance of diabetic rats were monitored. Read More

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The Traditional Usages, Chemical Components and Pharmacological Activities of : A Review.

Am J Chin Med 2022 ;50(2):389-440

Medicinal Plants Research Institute, Yunnan Academy of Agricultural Sciences, Kunming 650200, P. R. China.

As an endemic species, (F.A. Wolf) Ryvarden & Gilb. Read More

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Therapeutic Effect and Mechanism of Acupuncture in Autoimmune Diseases.

Am J Chin Med 2022 10;50(3):639-652. Epub 2022 Mar 10.

Department of Neurobiology, School of Basic Medical Sciences, Harbin Medical University Harbin, Heilongjiang 150081, P. R. China.

Autoimmune diseases (AIDs) are conditions arising from abnormal immune reactions to autoantigens, which can be defined as the loss of immune tolerance to autoantigens, causing the production of autoantibodies and subsequent inflammation and tissue injury. The etiology of AIDs remains elusive, which may involve both genetic and environmental factors, such as diet, drugs, and infections. Despite rapid progress in the treatment of autoimmune diseases over the past few decades, there is still no approach that can cure AIDs. Read More

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Integrative Analysis of the Gut Microbiota and Metabolome in Obese Mice with Electroacupuncture by 16S rRNA Gene Sequencing and HPLC-MS-based Metabolic Profiling.

Am J Chin Med 2022 10;50(3):673-690. Epub 2022 Mar 10.

College of Acupuncture and Tuina, Guizhou University of Traditional Chinese Medicine, Dongqing South Road, Guiyang, Guizhou 550025, P. R. China.

Acupuncture has been used to treat numerous diseases such as obesity in China for thousands of years. Several mechanisms of acupuncture on obesity have been surveyed based on metabolomics, but the effects of acupuncture on the alterations in the gut flora are still unclear. In this study, an integrated approach based on 16S rRNA gene sequencing combined with high-performance liquid chromatography-mass spectrometry (HPLC-MS) metabolic profiling was conducted to investigate the effects of acupuncture on high-fat-diet-induced obesity through the regulation of the relative abundances of gut microbiota and their relationships with biomarker candidates. Read More

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The Changing Global Landscape in the Development of Artemisinin-Based Treatments: A Clinical Trial Perspective.

Am J Chin Med 2022 10;50(3):733-748. Epub 2022 Mar 10.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, P. R. China.

Artemisinin and its derivatives (ARTs), due to their potent antimalarial activities, are widely used as frontline antimalarials across the world. Although the large-scale deployment of ARTs has significantly contributed to a substantial decline in malaria deaths, the global malaria burden is still high. New antimalarial treatments need to be developed to manage the growing artemisinin resistance. Read More

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Traditional Uses, Phytochemistry, Pharmacology, Quality Control, Industrial Application, Pharmacokinetics and Network Pharmacology of : A Comprehensive Review.

Am J Chin Med 2022 10;50(3):691-721. Epub 2022 Mar 10.

Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Clinical Medicial College, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

Pogostemonis Herba (PH) is the dried aerial parts of (Blanco) Benth, which is mainly distributed and used in Asian countries. PH is an aromatic damp-resolving drug in traditional Chinese medicine (TCM), which is usually used for the treatment of vomiting, chest tension, tiredness, abdominal pain, diarrhea, and headache. In this review, the summary of chemical constituents in the aerial parts, biological activities, history of uses, quality control methods, industrial applications, pharmacokinetics and network pharmacology are reported. Read More

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Cordyceps Improves Obesity and its Related Inflammation via Modulation of Abundance and Bile Acid Metabolism.

Am J Chin Med 2022 10;50(3):817-838. Epub 2022 Mar 10.

State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, P. R. China.

Dysbiotic gut microbiota has been identified as a primary mediator of inherent inflammation that underlies the pathogenesis of obesity. Cordyceps comprises the larval body and the stroma of (BerK.) Sacc. Read More

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Ameliorative Effects of Malonyl Ginsenoside from on Glucose-Lipid Metabolism and Insulin Resistance via IRS1/PI3K/Akt and AMPK Signaling Pathways in Type 2 Diabetic Mice.

Am J Chin Med 2022 10;50(3):863-882. Epub 2022 Mar 10.

College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, P. R. China.

Our previous study has revealed that malonyl-ginsenosides from (PG-MGR) play a crucial role in the treatment of T2DM. However, its potential mechanism was still unclear. In this study, we investigated the anti-diabetic mechanisms of action of PG-MGR in high fat diet-fed (HFD) and streptozotocin-induced diabetic mice and determined the main constituents of PG-MGR responsible for its anti-diabetic effects. Read More

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Exploring the Potential Pharmacological Mechanism of Hesperidin and Glucosyl Hesperidin against COVID-19 Based on Bioinformatics Analyses and Antiviral Assays.

Am J Chin Med 2022 2;50(2):351-369. Epub 2022 Mar 2.

Department of Respirology & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen 518020, P. R. China.

The development of anti-COVID-19 drugs has become the top priority since the outbreak of the epidemic, and Traditional Chinese medicine plays an important role in reducing mortality. Here, hesperidin and its glycosylation product, glucosyl hesperidin were selected to determine their antiviral activity against SARS-CoV-2 due to their structural specificity as reported. To be specific, their binding ability with ACE2, M, S, RBD and N proteins were verified with both and wet lab methods, i. Read More

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A Systematic Review on Polysaccharides from Genus: Recent Advances in the Preparation, Structural Characterization, Bioactive Molecular Mechanisms, and Applications.

Am J Chin Med 2022 7;50(2):471-509. Epub 2022 Feb 7.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China.

polysaccharides (DPSs) have aroused people's increasing attention in recent years as a result of their outstanding edible and medicinal values and non-toxic property. This review systematically summarized recent progress in the different preparation techniques, structural characteristics, modification, various pharmacological activities and molecular mechanisms, structure-activity relationships, and current industrial applications in the medicinal, food, and cosmetics fields of DPSs. Additionally, some recommendations for future investigations were provided. Read More

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Effectiveness of Integrative Chinese-Western Medicine for Chronic Kidney Disease and Diabetes: A Retrospective Cohort Study.

Am J Chin Med 2022 7;50(2):371-388. Epub 2022 Feb 7.

Department of Medicine, The University of Hong Kong, Hong Kong SAR, P. R. China.

Diabetes and chronic kidney disease (CKD) are pandemic, requiring more therapeutic options. This retrospective cohort evaluated the effectiveness, safety profile and prescription pattern of a pilot integrative medicine service program in Hong Kong. Data from 38 patients with diabetes and CKD enrolled to receive 48-week individualized add-on Chinese medicine (CM) were retrieved from the electronically linked hospital database. Read More

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A Systemic Review for Ethnopharmacological Studies on Fortune: Bioactive Compounds and their Therapeutic Insights.

Am J Chin Med 2022 9;50(1):161-207. Epub 2022 Feb 9.

School of Science, Tropical Medicine and Biology Multidisciplinary Platform, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya, 47500 Selangor, Malaysia.

Fortune is a biennial Chinese woad of the Cruciferae family. It is primarily cultivated in China, where it was a staple in indigo dye manufacture till the end of the 17th century. Today, is used primarily as a therapeutic herb in traditional Chinese medicine (TCM). Read More

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February 2022

Osthole Exerts Inhibitory Effects on Hypoxic Colon Cancer Cells via EIF2[Formula: see text] Phosphorylation-mediated Apoptosis and Regulation of HIF-1[Formula: see text].

Am J Chin Med 2022 3;50(2):621-637. Epub 2022 Feb 3.

Institute of Medical Sciences, Tzu Chi University, Hualien 970374, Taiwan, ROC.

Hypoxic microenvironment and dysregulated endoplasmic reticulum stress/unfolded protein response (UPR) system are considered important factors that promote cancer progression. Although osthole extracted from (Fructus Cnidii) has been confirmed to exhibit an anticancer activity in various cancers, the effects of osthole in hypoxic colon cancer cells have not been explored. Therefore, the aim of this study was to examine whether osthole has an inhibitory effect on hypoxic colon cancer HCT116 cells and further investigate the underlying molecular mechanisms. Read More

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Notoginsenoside R1, An Active Compound from , Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis via MAPK Signaling Pathway.

Am J Chin Med 2022 3;50(2):511-523. Epub 2022 Feb 3.

Department of Gastroenterology, Lianyungang Hospital of Traditional Chinese Medicine, Lianyungang, Jiangsu Province 222004, P. R. China.

Activation of the hepatic stellate cell is implicated in pathological vascularization during development of liver fibrosis. MAPK signaling is involved in the activation of hepatic stellate cell. Oxidative stress and inflammation are also involved in the pathogenesis of liver fibrosis. Read More

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Regulating the Imbalance of Gut Microbiota by L. Polyphenols to Alleviate Dextran Sulfate Sodium-induced Inflammatory Bowel Diseases.

Am J Chin Med 2022 3;50(2):553-568. Epub 2022 Feb 3.

Jiangxi Key Laboratory of Natural Products and Functional Food, School of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, P. R. China.

L. is used not only as a kind of traditional Chinese herbal medicinal ingredients with various pharmacological properties, but also as food in certain parts of China. However, it is by far still unclear whether L. Read More

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Anticancer Effects of via Cell Cycle Arrest, Necrosis, Apoptosis, and Endoplasmic Reticulum Stress.

Am J Chin Med 2022 3;50(2):569-587. Epub 2022 Feb 3.

Department of Biochemistry, Taipei City 114, Taiwan, ROC.

Dandelion ( species) is a wild plant with over 2500 species. Flavonoids, phenolic compounds, saponins, sesquiterpenes, and sugars have been detected in the organs of , and for centuries it has been used in traditional medicine for the relief and treatment of various diseases. However, details of its working mechanism remain unclear. Read More

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Proapoptotic Effect of Icariin on Human Ovarian Cancer Cells via the NF-[Formula: see text]B/PI3K-AKT Signaling Pathway: A Network Pharmacology-Directed Experimental Investigation.

Am J Chin Med 2022 3;50(2):589-619. Epub 2022 Feb 3.

Guangzhou University of Traditional Chinese Medicine, Huizhou Traditional Chinese Medicine Hospital, Huizhou, Guangdong 516001, P. R. China.

Based on network pharmacology tools and public bioinformatics databases, the pharmacodynamic target and key mechanism of icariin (ICA) in the treatment of ovarian cancer (OC) were identified and experimentally verified. Our previous research showed that TNF, MMP9, STAT3, PIK3CA, ERBB2, MTOR, IL2, PTGS2, KDR and F2 are important targets of ICA in the treatment of OC. TNF, as a hub gene in tumor tissues, was associated with poor prognosis. Read More

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Efficacy and Safety of Chinese Medicine for COVID-19: A Systematic Review and Meta-Analysis.

Am J Chin Med 2022 3;50(2):333-349. Epub 2022 Feb 3.

School of Public Health, Zhejiang Chinese Medical University, Hangzhou 310053, P. R. China.

This systematic review and meta-analysis aimed to evaluate the efficacy and safety of traditional Chinese medicine for COVID-19 treatment with a focus on the benefits of symptomatic relief and time-related indexes. Seven electronic databases (PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure, Chongqing VIP, Wanfang Data, and Chinese Clinical Trial Registry) were systematically searched from their beginning to April 2021. Only randomized controlled trials (RCTs) comparing patients using Western therapy (WT) alone and those using additional Chinese medicine (WT [Formula: see text] CM) were included. Read More

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