368,617 results match your criteria American Business Law Journal[Journal]


Well-Being and Education of Urology Residents During the COVID-19 Pandemic: Results of an American National Survey.

Int J Clin Pract 2020 May 27. Epub 2020 May 27.

Department of Urology, SUNY Downstate College of Medicine, Brooklyn, NY, USA.

Background: The rapid spread of COVID-19 has placed tremendous strain on the American healthcare system. Few prior studies have evaluated the well-being of or changes to training for American resident physicians during the COVID-19 pandemic. We aim to study predictors of trainee well-being and changes to clinical practice using an anonymous survey of American urology residents. Read More

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http://dx.doi.org/10.1111/ijcp.13559DOI Listing

ASPEN Lipid Injectable Emulsion Safety Recommendations, Part 1: Background and Adult Considerations.

Nutr Clin Pract 2020 May 27. Epub 2020 May 27.

BriovaRx Infusion Services, Columbia, Maryland, USA.

Lipid injectable emulsions (ILEs) are complex pharmaceutical formulations used as a source of energy and essential fatty acids in parenteral nutrition. Issues associated with ILE use are distinctly different from oral fat and arise from emulsion stability, dose, and infusion tolerance. Since 1975, soybean oil has been the consistent source oil used in ILE formulations in the US. Read More

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http://dx.doi.org/10.1002/ncp.10496DOI Listing

Contemporary Analysis of Rhytidectomy Using the Tracking Operations and Outcomes for Plastic Surgeons Database with 13,346 Patients.

Plast Reconstr Surg 2020 Jun;145(6):1402-1408

Gainesville, Fla. From the Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Florida Health.

Background: Rhytidectomy is a popular procedure for facial rejuvenation, but an up-to-date, comprehensive, and broadly representative appraisal is lacking.

Methods: A cohort of patients undergoing rhytidectomy between 2008 and 2016 was identified from the Tracking Outcomes in Plastic Surgery database. Perioperative data and patient characteristics were analyzed with respect to adverse events. Read More

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http://dx.doi.org/10.1097/PRS.0000000000006813DOI Listing

Breast Implant Imaging Surveillance among U.S. Plastic Surgeons: U.S. Food and Drug Administration Recommendations versus Clinical Reality.

Plast Reconstr Surg 2020 Jun;145(6):1381-1387

Hershey, Pa.; and Houston, Texas From the Department of Surgery, Division of Plastic Surgery, Pennsylvania State University, College of Medicine; and the Departments of Plastic Surgery and Diagnostic Radiology, M. D. Anderson Cancer Center, University of Texas.

Background: Device rupture is considered a major complication associated with breast implants. The U.S. Read More

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http://dx.doi.org/10.1097/PRS.0000000000006812DOI Listing

Current Trends in Tonometry and Tonometer Tip Disinfection.

J Glaucoma 2020 May 26. Epub 2020 May 26.

Harvard Medical School, Massachusetts Eye and Ear, Department of Ophthalmology, 243 Charles Street, Boston, MA 02114.

PRéCIS:: A survey among members of the American Glaucoma Society and the American Optometry Association on tonometer preference and tonometer disinfection indicates a shift to disposable tonometer tips compared to 1987.

Purpose: This survey's purpose was to determine how eye care providers responded to the 2008 Centers of Disease Control (CDC) tonometer disinfection guidelines, which recommend 10% hypochlorite (dilute bleach) for reusable tonometers. Tonometers measure the eye pressure when they touch the cornea, an essential part of the eye exam. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001566DOI Listing

Disparities in Burnout and Satisfaction With Work-Life Integration in U.S. Physicians By Gender and Practice Setting.

Acad Med 2020 May 26. Epub 2020 May 26.

A.L. Marshall is associate professor of medicine, Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota; ORCID: http://orcid.org/0000-0001-7388-0422. L.N. Dyrbye is professor of medicine and medical education, Division of Community Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota. T.D. Shanafelt is Jeanie and Stewart Ritchie Professor of Medicine and associate dean, Stanford School of Medicine, Stanford, California. C.A. Sinsky is vice president of professional satisfaction, American Medical Association, Chicago, Illinois. D. Satele is a statistician, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota. M. Trockel is clinical associate professor, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California. M. Tutty is group vice president of professional satisfaction and practice sustainability, American Medical Association, Chicago, Illinois. C.P. West is professor of medicine, medical education, and biostatistics, Division of General Internal Medicine, Department of Internal Medicine, and Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; ORCID: https://orcid.org/0000-0003-1628-5023.

Purpose: To explore the interaction between practice setting (academic practice [AP], private practice [PP]) and gender in relation to physician burnout and satisfaction with work-life integration (WLI).

Method: In 2017, the authors administered a cross-sectional survey of U.S. Read More

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http://dx.doi.org/10.1097/ACM.0000000000003521DOI Listing

Promoting Value through Patient-Centered Communication: A Multisite Validity Study of Third-Year Medical Students.

Acad Med 2020 May 26. Epub 2020 May 26.

N. Natt is associate professor of medicine, Mayo Clinic, Rochester, Minnesota. M. Dekhtyar is former research associate, Medical Education Outcomes, American Medical Association, Chicago, Illinois. Y.S. Park is associate professor of medical education, College of Medicine, University of Illinois at Chicago, Chicago, Illinois. K. Shinkai is professor of dermatology, University of California, San Francisco, San Francisco, California; ORCID: https://orcid.org/0000-0003-0384-1158. P.A. Carney is professor of family medicine, Oregon Health & Science University, Portland, Oregon; ORCID: https://orcid.org/0000-0002-2937-655X. T.L. Fancher is professor of medicine, Division of General Medicine, University of California Davis, Sacramento, California; ORCID: https://orcid.org/0000-0001-5486-6123. L. Lawson is associate professor of emergency medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina. A.N. Leep Hunderfund is assistant professor of neurology, Mayo Clinic, and associate director, Mayo Clinic Program in Professionalism and Values, Rochester, Minnesota; ORCID: https://orcid.org/0000-0002-7784-504X.

Purpose: To examine validity evidence for a standardized patient scenario assessing medical students' ability to promote value using patient-centered communication (in response to a patient requesting an unnecessary test) and to explore the potential effect of various implementation and curricular factors on student scores.

Method: Third-year medical students (N = 516) from 5 U.S. Read More

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http://dx.doi.org/10.1097/ACM.0000000000003519DOI Listing

Effectiveness of social media approaches to recruiting young adult cigarillo smokers.

J Med Internet Res 2019 May 25. Epub 2019 May 25.

Department of Family Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park RoadFM, Portland, US.

Background: The prevalence of social media (SM) use among youth and young adults suggests SM as an appropriate platform for study recruitment from this population. Previous studies have examined the use of SM for recruitment, but few have compared different SM platforms, and none to our knowledge have attempted to recruit cigarillo users.

Objective: The purpose of this study is to examine the effectiveness of different SM platforms and advertisement images for recruiting 14-28-year-old cigarillo users to complete a cigarillo use survey. Read More

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http://dx.doi.org/10.2196/12619DOI Listing

Whole Genome Sequencing Identifies Novel Functional Loci Associated with Lung Function in Puerto Rican Youth.

Am J Respir Crit Care Med 2020 May 27. Epub 2020 May 27.

UC San Francisco, San Francisco, California, United States.

Rationale: Puerto Ricans have the highest childhood asthma prevalence in the United States (23.6%), however, the etiology is uncertain.

Objective: In this study, we sought to uncover the genetic architecture of lung function in Puerto Rican youth with and without asthma who were recruited from the island (n=836). Read More

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http://dx.doi.org/10.1164/rccm.202002-0351OCDOI Listing

Updates to Medicare's Quality Payment Program That May Impact You.

Arch Pathol Lab Med 2020 Jun;144(6):679-685

From the Department of Pathology, Duke University Medical Center, Durham, North Carolina (Dr Cardona); Advocacy Division, College of American Pathologists, Washington, DC (Mss Peditto and Singh); and the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston (Dr Black-Schaffer).

Context.—: Within Medicare's Quality Payment Program, and more specifically the Merit-based Incentive Payment System, pathologists stand to potentially lose or gain approximately $2 billion during the initial 7 years of the program. If you or your group provides services to Medicare beneficiaries, you will likely need to comply with the program. Read More

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http://dx.doi.org/10.5858/arpa.2019-0376-RADOI Listing

Developing Pathology Measures for the Quality Payment Program-Part I: A Quest for Meaningful Measures.

Arch Pathol Lab Med 2020 Jun;144(6):686-696

From the Department of Pathology, University of Colorado-Anschutz Medical Campus, Aurora (Dr Bocsi); the Department of Pathology, NorthShore University Health System, Evanston, Illinois (Dr Kang); the Advocacy Division, College of American Pathologists, Washington, DC (Mss Kennedy, Singh, and Peditto); and the Department of Pathology, Duke University Medical Center, Durham, North Carolina (Dr Cardona). Ms Kennedy is currently with the American Society of Clinical Oncology, Arlington, Virginia.

Context.—: Quality measures assess health care processes, outcomes, and patient perceptions associated with high-quality health care, which is commonly defined as care that is effective, safe, efficient, patient centered, equitable, and timely. Such measures are now being used in order to incentivize provision of high-quality health care. Read More

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http://dx.doi.org/10.5858/arpa.2019-0377-OADOI Listing

Developing Pathology Measures for the Quality Payment Program-Part II: Overcoming Challenges With Data Capture to Maximize Reimbursement.

Arch Pathol Lab Med 2020 Jun;144(6):697-705

From the Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston (Dr Kelley); the Department of Pathology, Warren Alpert Medical School of Brown University, Lifespan Academic Medical Center, Providence, Rhode Island (Dr Patil); the Advocacy Division, College of American Pathologists, Washington, DC (Mss Kennedy, Singh, and Peditto); and the Department of Pathology, Duke University Medical Center, Durham, North Carolina (Dr Cardona). Ms Kennedy is currently with the American Society of Clinical Oncology, Arlington, Virginia.

Context.—: Quality measures are a cornerstone in measuring physicians' performance within the Centers for Medicare & Medicaid Services' Quality Payment Program (QPP). Clinicians' performance on quality measures and other categories within the QPP determines Medicare part B payment adjustments. Read More

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http://dx.doi.org/10.5858/arpa.2019-0378-OADOI Listing

Validation of the American Association for the Surgery of Trauma grading system for acute appendicitis severity.

J Trauma Acute Care Surg 2020 Jun;88(6):839-846

From the Department of Surgery (C.A.M., J.R.M., J.W.S., D.A.M.-A., M.R.H.), and Center for Health Outcomes and Policy (A.H.C.-N., B.L.H., M.P.G., J.W.S., M.R.H.), University of Michigan, Ann Arbor, Michigan.

Objective: The American Association for the Surgery of Trauma (AAST) developed an anatomic grading system to assess disease severity through increasing grades of inflammation. Severity grading can then be utilized in risk-adjustment and stratification of patient outcomes for clinical benchmarking. We sought to validate the AAST appendicitis grading system by examining the ability of AAST grade to predict clinical outcomes used for clinical benchmarking. Read More

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http://dx.doi.org/10.1097/TA.0000000000002674DOI Listing

Universal background checks for handgun purchases can reduce homicide rates of African Americans.

J Trauma Acute Care Surg 2020 Jun;88(6):825-831

From the Division of Traumatology, Surgical Critical Care, and Emergency Surgery (E.J.K., N.D.M., C.A.S., C.W.S., P.M.R., M.J.S.), University of Pennsylvania, Philadelphia, Pennsylvania; Mailman School of Public Health (C.N.M.), Columbia University, New York, New York; Department of Epidemiology and Preventive Medicine, Monash University (C.N.M.), Melbourne, Australia; Naval Medical Center San Diego (E.J.O.), San Diego, California; Department of Social Policy and Intervention, Oxford University (D.K.H.), Oxford, United Kingdom; Department of Biostatistics and Epidemiology (D.J.W.), University of Pennsylvania, Philadelphia, Pennsylvania; Division of Acute and Critical Care Surgery, Washington University in St. Louis (M.H.H.), St. Louis, Missouri.

Background: Federal law requires background checks for firearms purchased from licensed dealers, but states can extend requirements to private sales of handguns and purchases at gun shows (universal background checks for handguns [UBC-HG]). Although firearm homicide disproportionately affects African Americans, little is known about how UBG-HG impacts African Americans. We hypothesized that implementation of UBC-HG would reduce rates of firearm homicide of African Americans. Read More

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http://dx.doi.org/10.1097/TA.0000000000002689DOI Listing

Executive Summary of the Early-Onset Breast Cancer Evidence Review Conference.

Obstet Gynecol 2020 Jun;135(6):1457-1478

Department of Obstetrics and Gynecology, Virginia Commonwealth University School of Medicine, Richmond, Virginia; the Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, Michigan; the Department of Women's Health, the University of Texas at Austin Dell Medical School, Austin, Texas; the Departments of Obstetrics and Gynecology and Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; the Department of Obstetrics and Gynecology, Thomas Jefferson University Hospital, Sidney Kimmel Medical College, Philadelphia, Pennsylvania; Southeast Kaiser Permanente Medical Group, Atlanta, Georgia; the Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington; the Department of Obstetrics and Gynecology, University of Connecticut Medical School, Farmington, Connecticut; and the American College of Obstetricians and Gynecologists, Washington, DC.

The Centers for Disease Control and Prevention launched the Bring Your Brave campaign to increase knowledge about early-onset breast cancer, defined as breast cancer in women aged 18-45 years. The American College of Obstetricians and Gynecologists convened a panel of experts in breast disease from the Society for Academic Specialists in General Obstetrics and Gynecology to review relevant literature, validated tools, best practices, and practice guidelines as a first step toward developing educational materials for women's health care providers about early-onset breast cancer. Panel members conducted structured literature reviews, which were then reviewed by other panel members and discussed at an in-person meeting of stakeholder professional and patient advocacy organizations in April 2019. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003889DOI Listing

Maternal Mortality in the United States Compared With Ethiopia, Nepal, Brazil, and the United Kingdom: Contrasts in Reproductive Health Policies.

Obstet Gynecol 2020 Jun;135(6):1362-1366

Department of Obstetrics, Gynecology and Reproductive Sciences and Health Policy, Bixby Center for Global Reproductive Health, University of California, San Francisco, California; the Committee on Maternal Mortality, Oswald Cruz Foundation, Department of Epidemiology and Quantitative Methods in Health, Rio de Janeiro, Brazil; the Royal College of Obstetricians and Gynecologists, London, United Kingdom; the Department of Obstetrics and Gynecology, St. Paul's Medical School, Addis Ababa, Ethiopia; and the Nepal Society of Obstetricians and Gynecologists, Kathmandu, Nepal.

Maternal mortality is falling in most of the world's countries, but, for 20 years, the United States has seen no reduction. Over this period, a dozen countries in various stages of development, all spending much less than the United States on health, achieved their United Nations' Millennium Development Goal of 2015 (Millennium Development Goal 5: improve maternal health), with substantial reductions in maternal mortality rates. To consider whether interventions successful in reducing global maternal mortality rates could help the United States to lower its rate, the American College of Obstetricians and Gynecologists, at the 2018 International Federation of Gynecology and Obstetrics' Rio de Janeiro World Congress, convened a panel of the presidents and representatives from five national societies with wide maternal mortality rate ranges and health expenditures and whose national societies had focused on reducing maternal mortality for Millennium Development Goal 5. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003870DOI Listing

Special Edition: COVID-19 Guest Editorial.

J Am Acad Orthop Surg 2020 Jun;28(11):435

Dr. Rose is from Mayo Clinic Minnesota, Rochester, MN. Dr. Rose is Deputy Editor, Journal of the American Academy of Orthopaedic Surgeons. Dr. Levine is an Editor-in-Chief of the Journal of the American Academy of Orthopaedic Surgeons, Rosemont, IL.

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http://dx.doi.org/10.5435/JAAOS-D-20-00337DOI Listing

Development and Validation of a Tool to Assess the Quality of Clinical Practice Guideline Recommendations.

JAMA Netw Open 2020 May 1;3(5):e205535. Epub 2020 May 1.

Department of Pediatrics, University of Antioquia, Medellín, Colombia.

Importance: Clinical practice guidelines (CPGs) may lack rigor and suitability to the setting in which they are to be applied. Methods to yield clinical practice guideline recommendations that are credible and implementable remain to be determined.

Objective: To describe the development of AGREE-REX (Appraisal of Guidelines Research and Evaluation-Recommendations Excellence), a tool designed to evaluate the quality of clinical practice guideline recommendations. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.5535DOI Listing

A Call to Include Death Disclosure Training Alongside Cardiopulmonary Resuscitation Training: After the Code.

JAMA Cardiol 2020 May 27. Epub 2020 May 27.

Emory Palliative Care Center, Department of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1001/jamacardio.2020.1279DOI Listing

Targeted next-generation sequencing for congenital hypothyroidism with positive neonatal TSH screening.

J Clin Endocrinol Metab 2020 May 27. Epub 2020 May 27.

Department of Pediatrics, Jichi Children's Medical Center Tochigi, Shimotsuke, Japan.

Purpose: Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder, however, its molecular etiology remains poorly understood.

Methods: We performed genetic analysis of 24 causative genes using next-generation sequencing in 167 CH cases (57 dyshormonogenesis (DH), 32 dysgenesis (TD) and 78 undiagnosed). The pathogenicity of variants was assessed by the American College of Medical Genetics guidelines, inheritance pattern and published evidence. Read More

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http://dx.doi.org/10.1210/clinem/dgaa308DOI Listing

Content and Quality of Infant Feeding Smartphone Apps: Five-Year Update on a Systematic Search and Evaluation.

JMIR Mhealth Uhealth 2020 May 27;8(5):e17300. Epub 2020 May 27.

Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.

Background: Parents use apps to access information on child health, but there are no standards for providing evidence-based advice, support, and information. Well-developed apps that promote appropriate infant feeding and play can support healthy growth and development. A 2015 systematic assessment of smartphone apps in Australia about infant feeding and play found that most apps had minimal information, with poor readability and app quality. Read More

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http://dx.doi.org/10.2196/17300DOI Listing

The Efficacy of Cognitive Processing Therapy for PTSD Related to Military Sexual Trauma in Veterans: A Review.

Authors:
Jason Boehler

J Evid Based Soc Work (2019) 2019 Nov-Dec;16(6):595-614. Epub 2019 Nov 24.

College of Social Work, Florida State University, Tallahassee, FL, USA.

Women currently comprise 12% of the total number of service personnel who have served in Operation Enduring Freedom, Operation Iraqi Freedom, and Operation New Dawn. Presently, 15% of active duty personnel, 17% of National Guard personnel, and 20% of new recruits are female. The number of female veterans utilizing the Veterans Health Administration has more than doubled, from 159,000 to 337,000 from 2000-2011 and is expected to double again within the next decade. Read More

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http://dx.doi.org/10.1080/26408066.2019.1666767DOI Listing
November 2019

The Equatoguinean Malaria Vaccine Initiative: From the Launching of a Clinical Research Platform to Malaria Elimination Planning in Central West Africa.

Am J Trop Med Hyg 2020 May 26. Epub 2020 May 26.

Ministry of Health and Social Welfare, Government of Equatorial Guinea, Malabo, Equatorial Guinea.

Fifteen years of investment in malaria control on Bioko Island, Equatorial Guinea (EG), dramatically reduced malaria-associated morbidity and mortality, but the impact has plateaued. To progress toward elimination, EG is investing in the development of a malaria vaccine. We assessed the unique public-private partnership that has had such a significant impact on malaria on Bioko Island and now added a major effort on malaria vaccine development. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0966DOI Listing

Accuracy of Nonexercise Prediction Equations for Assessing Longitudinal Changes to Cardiorespiratory Fitness in Apparently Healthy Adults: BALL ST Cohort.

J Am Heart Assoc 2020 May 27:e015117. Epub 2020 May 27.

Fisher Institute of Health and Well-Being Ball State University Muncie IN.

Background Repeated assessment of cardiorespiratory fitness (CRF) improves mortality risk predictions in apparently healthy adults. Accordingly, the American Heart Association suggests routine clinical assessment of CRF using, at a minimum, nonexercise prediction equations. However, the accuracy of nonexercise prediction equations over time is unknown. Read More

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http://dx.doi.org/10.1161/JAHA.119.015117DOI Listing

A Privileged Point of View: Effects of Subjective Socioeconomic Status on Naïve Realism and Political Division.

Pers Soc Psychol Bull 2020 May 27:146167220921043. Epub 2020 May 27.

The University of North Carolina at Chapel Hill, USA.

In the United States, both economic inequality and political conflict are on the rise. We investigated whether subjective socioeconomic status (SSS) may help explain why these dual patterns emerge. We hypothesized that higher SSS may increase naïve realism-the belief that one perceives the world as it is, rather than as interpreted through one's own knowledge and beliefs-regarding political issues. Read More

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http://dx.doi.org/10.1177/0146167220921043DOI Listing

Expression of HER-2/neu in Oral Squamous Cell Carcinoma.

Asian Pac J Cancer Prev 2020 May 1;21(5):1465-1470. Epub 2020 May 1.

Department of Prosthetic Dental Science, College of Dentistry, King Saud University, Research Chair for Biological Research in Dental Health, Riyadh, Saudi Arabia.

Background: HER-2/neu is a member of the human epidermal growth factor (HER) family of transmembrane tyrosine kinases, which is significantly associated with the pathogenesis of various cancer types. The aim was to evaluate the expression of HER-2/neu in oral squamous cell carcinoma (OSCC) as a potential biomarker to target antigens for specific immunotherapy in OSCC.

Methods: One hundred and forty histologically diagnosed OSCC cases were identified. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1465DOI Listing

Effectiveness of a Transanal Drainage Tube for the Prevention of Anastomotic Leakage after Laparoscopic Low Anterior Resection for Rectal Cancer.

Asian Pac J Cancer Prev 2020 May 1;21(5):1441-1444. Epub 2020 May 1.

Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China.

Background And Objective: Anastomotic leakage is one of the most serious complications after laparoscopic low anterior resection Low Anterior Resection (LAR) for rectal cancers. The purpose of this study was to evaluate the effectiveness of a transanal drainage tube placed for the prevention of anastomotic leakage after laparoscopic LAR.

Methods: The clinical data of 220 patients with rectal cancer who underwent laparoscopic LAR using the double stapling technique Double Stapling Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Technique (DST) from Jun 2017 to Dec 2018 were analyzed retrospectively at our institution. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1441DOI Listing

The Impact of Social Constraints on Insomnia Among African-American Breast Cancer Survivors: The Mediating Role of Fear of Recurrence.

Psychooncology 2020 May 27. Epub 2020 May 27.

Howard University, College of Medicine, Washington, District of Columbia.

Objective: Insomnia is a significant concern among African-American breast cancer survivors (BCS). Social constraints (SC)- receiving unsupportive or critical responses when expressing trauma-related emotions- and fear of recurrence (FOR) have been associated with insomnia. We examined FOR as a mediator in the relationship between SC and insomnia in African-American BCS. Read More

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http://dx.doi.org/10.1002/pon.5435DOI Listing

Multigene testing in breast cancer: What have we learned from the 21-gene recurrence score assay?

Breast J 2020 May 26. Epub 2020 May 26.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Most invasive breast cancers express hormone receptors (HR) and typically have a favorable prognosis following endocrine therapy. Patients at a higher risk of recurrence can be identified by multigene prognostic classifiers such as the 21-gene recurrence score (RS) assay, 70-gene prognostic signature, PAM-50, 12-gene molecular score, and others. The 21-gene RS assay (Oncotype Dx™, Genomic Health, Redwood City, CA) has level I clinical evidence and is the most widely used multigene assay in North America. Read More

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http://dx.doi.org/10.1111/tbj.13859DOI Listing

Diagnostic value of advanced semen analysis in evaluation of male infertility.

Andrologia 2020 May 26:e13625. Epub 2020 May 26.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Conventional semen analysis is the standard of care to initially evaluate the fertility status of a male patient. However, it has some limitations and among these are failure to correctly identify the aetiology underlying fertility problems, intra- and inter-observer variability and incomplete information about sperm function. Considering these drawbacks, advanced semen tests have been developed to assess male infertility, including sperm function tests, oxidative stress (OS) and sperm DNA fragmentation (SDF) tests. Read More

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http://dx.doi.org/10.1111/and.13625DOI Listing

Left atrial stiffness in women with ischemia and no obstructive coronary artery disease: Novel insight from left atrial feature tracking.

Clin Cardiol 2020 May 27. Epub 2020 May 27.

Department of Kinesiology, University of Texas, Arlington, Texas, USA.

Background: Women with signs and symptoms of ischemia and no obstructive coronary artery disease (INOCA) are at risk of heart failure with preserved ejection fraction (HFpEF); however, the mechanism for HFpEF progression remains unclear. Studies in INOCA have largely focused on left ventricular function. The left atrium serves an important role in maintaining transmitral flow, and is impaired in HFpEF; however, it remains unclear if left atrial function is impaired in INOCA. Read More

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http://dx.doi.org/10.1002/clc.23395DOI Listing

The Impact of obesity and diabetes mellitus on pancreatic cancer: Molecular mechanisms and clinical perspectives.

J Cell Mol Med 2020 May 26. Epub 2020 May 26.

Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

The incidence of obesity and type 2 diabetes (T2DM) in the Western world has increased dramatically during the recent decades. According to the American Cancer Society, pancreatic cancer (PC) is the fourth leading cause of cancer-related death in the United States. The relationship among obesity, T2DM and PC is complex. Read More

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http://dx.doi.org/10.1111/jcmm.15413DOI Listing

MicroRNA-208a: a Good Diagnostic Marker and a Predictor of no-Reflow in STEMI Patients Undergoing Primary Percutaneuos Coronary Intervention.

J Cardiovasc Transl Res 2020 May 26. Epub 2020 May 26.

Department of Chemistry, School of Science and Engineering, The American University in Cairo, Cairo, Egypt.

MicroRNA-208a is a cardiac specific oligo-nucleotide. We aimed at investigating the ability of microRNA-208a to diagnose myocardial infarction and predict the outcome of primary percutaneuos coronary angiography (PCI). Patients (n = 75) presented by chest pain were recruited into two groups. Read More

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http://dx.doi.org/10.1007/s12265-020-10020-9DOI Listing

Improvement in osseointegration of tricalcium phosphate-zircon for orthopedic applications: an in vitro and in vivo evaluation.

Med Biol Eng Comput 2020 May 27. Epub 2020 May 27.

New Technologies Research Center, Amirkabir University of Technology, Tehran, 15875-4413, Iran.

Similar to metallic implant, using the compact bio-nanocomposite can provide a suitable strength due to its high stiffness and providing sufficient adhesion between bone and orthopedic implant. Therefore, using zirconia-reinforced calcium phosphate composites with new generation of calcium silicate composites was considered in this study. Additionally, investigation of microstructure, apatite formation, and mechanical characteristic of synthetic compact bio-nanocomposite bones was performed. Read More

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http://dx.doi.org/10.1007/s11517-020-02157-1DOI Listing

Development and evaluation of a simulation-based transition to clerkship course.

Perspect Med Educ 2020 May 26. Epub 2020 May 26.

Departments of Behavioral Neuroscience, Psychiatry and the Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, USA.

Background: Transition to clerkship courses bridge the curricular gap between preclinical and clinical medical education. However, despite the use of simulation-based teaching techniques in other aspects of medical training, these techniques have not been adequately described in transition courses. We describe the development, structure and evaluation of a simulation-based transition to clerkship course. Read More

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http://dx.doi.org/10.1007/s40037-020-00590-4DOI Listing

Discrimination and Multimorbidity Among Black Americans: Findings from the National Survey of American Life.

J Racial Ethn Health Disparities 2020 May 26. Epub 2020 May 26.

Research and Development Unit, CIBERSAM, Parc Sanitari Sant Joan de Déu, Barcelona, Spain.

Objectives: There is a notable lack of research on the risk factors for multimorbidity, which has become more common over recent decades. Black Americans experience discrimination more often than their White counterparts, and also have significantly higher prevalence of multimorbidity. This paper examines the associations between discrimination and multimorbidity among Black Americans. Read More

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http://dx.doi.org/10.1007/s40615-020-00773-zDOI Listing

Mindfulness and Posttraumatic Stress Disorder Symptom Severity in Urban African-American High School Students.

Psychiatr Q 2020 May 26. Epub 2020 May 26.

College of Education, Criminal Justice, and Human Services, Evaluation Services Center, University of Cincinnati, Cincinnati, OH, USA.

Objectives: The aim of the current study was to examine the relations among mindfulness, posttraumatic stress disorder (PTSD) symptom severity, and stressful life events (SLEs) in African-American urban adolescents. Another aim was to examine mindfulness as a moderator of the relation between SLEs and PTSD symptom severity in this population.

Method: Eighty-eight African-American high school students from a low-income urban community completed measures of demographics, PTSD symptom severity, SLEs, and mindfulness. Read More

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http://dx.doi.org/10.1007/s11126-020-09774-xDOI Listing

Constructing a Human Atrial Fibre Atlas.

Ann Biomed Eng 2020 May 26. Epub 2020 May 26.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.

Atrial anisotropy affects electrical propagation patterns, anchor locations of atrial reentrant drivers, and atrial mechanics. However, patient-specific atrial fibre fields and anisotropy measurements are not currently available, and consequently assigning fibre fields to atrial models is challenging. We aimed to construct an atrial fibre atlas from a high-resolution DTMRI dataset that optimally reproduces electrophysiology simulation predictions corresponding to patient-specific fibre fields, and to develop a methodology for automatically assigning fibres to patient-specific anatomies. Read More

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http://dx.doi.org/10.1007/s10439-020-02525-wDOI Listing

Barriers to lung cancer referral, diagnosis, and treatment in Central America and the Caribbean: the health professionals' perspectives.

Support Care Cancer 2020 May 26. Epub 2020 May 26.

Personalized Healthcare, Genentech, South San Francisco, CA, 94080, USA.

Purpose: To identify the perspectives from healthcare providers about the limitations in referral, diagnosis, and treatment of lung cancer (LC) patients.

Methods: A cross-sectional study through an Internet-based survey was addressed to physicians of multidisciplinary teams in charge of LC patients from Cuba, Curacao, Costa Rica, Dominican Republic, El Salvador, Guatemala, Honduras, Jamaica, Panama, and Trinidad and Tobago. The questions focused on physicians' perspectives concerning waiting times and the availability of diagnostic and staging procedures in their settings, as well as the access to systemic therapies and continuous medical education (CME). Read More

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http://dx.doi.org/10.1007/s00520-020-05532-8DOI Listing

PSA, stage, grade and prostate cancer specific mortality in Asian American patients relative to Caucasians according to the United States Census Bureau race definitions.

World J Urol 2020 May 26. Epub 2020 May 26.

Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada.

Background: The United States Census Bureau recommends distinguishing between "Asians" vs. "Native Hawaiians or Other Pacific Islanders" (NHOPI). We tested for prognostic differences according to this stratification in patients with prostate cancer (PCa) of all stages. Read More

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http://dx.doi.org/10.1007/s00345-020-03242-8DOI Listing

Guidelines for the assessment of bone density and microarchitecture in vivo using high-resolution peripheral quantitative computed tomography.

Osteoporos Int 2020 May 26. Epub 2020 May 26.

Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Introduction: The application of high-resolution peripheral quantitative computed tomography (HR-pQCT) to assess bone microarchitecture has grown rapidly since its introduction in 2005. As the use of HR-pQCT for clinical research continues to grow, there is an urgent need to form a consensus on imaging and analysis methodologies so that studies can be appropriately compared. In addition, with the recent introduction of the second-generation HrpQCT, which differs from the first-generation HR-pQCT in scan region, resolution, and morphological measurement techniques, there is a need for guidelines on appropriate reporting of results and considerations as the field adopts newer systems. Read More

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http://dx.doi.org/10.1007/s00198-020-05438-5DOI Listing

Meeting Our New Challenges with Thoughtfulness, Dedication, and Sacrifice.

Authors:
Ajay D Wasan

Pain Med 2020 May 26. Epub 2020 May 26.

President, American Academy of Pain Medicine.

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http://dx.doi.org/10.1093/pm/pnaa157DOI Listing

From Normal Flora to Brain Abscesses: A Review of .

Front Microbiol 2020 7;11:826. Epub 2020 May 7.

Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Byblos, Lebanon.

is a β-hemolytic Gram-positive member of the group (SAG). Despite being a part of the normal microbiota, it is one of the most common pathogens associated with brain and liver abscesses and thoracic empyema, increasing as a result the morbidity and mortality rates in affected patients. Though there are numerous published case reports on infections, it is still understudied compared to other SAG members. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221147PMC

EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair.

Oncogene 2020 May 26. Epub 2020 May 26.

Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, 30322, USA.

Small cell lung cancer (SCLC) is a highly aggressive malignancy with poor outcomes associated with resistance to cisplatin-based chemotherapy. Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2), which silences transcription through trimethylation of histone H3 lysine 27 (H3K27me3) and has emerged as an important therapeutic target with inhibitors targeting its methyltransferase activity under clinical investigation. Here, we show that EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair (NER) and govern cisplatin resistance in SCLC. Read More

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http://dx.doi.org/10.1038/s41388-020-1332-2DOI Listing

Intraductal pancreatic cancer is less responsive than cancer in the stroma to neoadjuvant chemotherapy.

Mod Pathol 2020 May 26. Epub 2020 May 26.

Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Neoadjuvant chemotherapy (NAC) is often the treatment of choice for borderline resectable and locally advanced invasive pancreatic ductal adenocarcinoma (PDAC); however, most cancers only partially respond to therapy. We hypothesized that the location of residual neoplastic cells in resected specimens following NAC could provide a clue as to the mechanisms of resistance. PDAC cells invade the stroma but can also invade back into and spread via the pancreatic ducts, which has been referred to as "cancerization of ducts" (COD). Read More

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http://dx.doi.org/10.1038/s41379-020-0572-6DOI Listing

Participatory practices at work change attitudes and behavior toward societal authority and justice.

Nat Commun 2020 May 26;11(1):2633. Epub 2020 May 26.

420 Peretsman Scully Hall, Department of Psychology, Princeton University, Princeton, NJ, 08544, USA.

Generalized attitudes toward authority and justice are often conceptualized as individual differences that are resistant to enduring change. However, across two field experiments with Chinese factory workers and American university staff, small adjustments to people's experience of participation in the workplace shifted these attitudes one month later. Both experiments randomly assigned work groups to a 20-minute participatory meeting once per week for six weeks, in which the supervisor stepped aside and workers discussed problems, ideas, and goals regarding their work (vs. Read More

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http://dx.doi.org/10.1038/s41467-020-16383-6DOI Listing

Electrical switching between exciton dissociation to exciton funneling in MoSe/WS heterostructure.

Nat Commun 2020 May 26;11(1):2640. Epub 2020 May 26.

Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.

The heterostructure of monolayer transition metal dichalcogenides (TMDCs) provides a unique platform to manipulate exciton dynamics. The ultrafast carrier transfer across the van der Waals interface of the TMDC hetero-bilayer can efficiently separate electrons and holes in the intralayer excitons with a type II alignment, but it will funnel excitons into one layer with a type I alignment. In this work, we demonstrate the reversible switch from exciton dissociation to exciton funneling in a MoSe/WS heterostructure, which manifests itself as the photoluminescence (PL) quenching to PL enhancement transition. Read More

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http://dx.doi.org/10.1038/s41467-020-16419-xDOI Listing

Second line anti-retroviral therapy failure in a pediatric cohort of an Ethiopian tertiary hospital: a retrospective observational study.

Sci Rep 2020 May 26;10(1):8699. Epub 2020 May 26.

Department of Pediatrics and child health, College of health sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Sub-Saharan Africa carries the largest burden of pediatric HIV infection. The success of second line anti-retroviral treatment and related factors among African children is not well-defined. Objectives: We aimed to identify the rate and determinants of second line anti-retroviral treatment failure among children and adolescents on follow-up at an Ethiopian tertiary teaching hospital. Read More

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http://dx.doi.org/10.1038/s41598-020-65714-6DOI Listing

Resistance Training for Children and Adolescents.

Pediatrics 2020 May 26. Epub 2020 May 26.

Department of Orthopedics, University of Maryland, College Park, Maryland.

Resistance training is becoming more important as an integral part of comprehensive sport training regimens, school physical education classes, and after-school fitness programs. The increasing number of youth who are involved in sport activities, coupled with the health problems of inactivity and being overweight, have resulted in increased interest in resistance training. Secular declines in measures of muscular fitness in modern-day youth highlight the need for participation in youth resistance training for nonathletes as well as athletes. Read More

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http://dx.doi.org/10.1542/peds.2020-1011DOI Listing