372,005 results match your criteria American Bankruptcy Law Journal[Journal]


Single- versus dual-attending strategy for spinal deformity surgery: 2-year experience and systematic review of the literature.

J Neurosurg Spine 2020 Jul 10:1-12. Epub 2020 Jul 10.

2Neurosurgery, Stanford University Hospitals and Clinics, Stanford, California.

Objective: Adult spinal deformity (ASD) surgery is complex and associated with high morbidity and complication rates. There is growing evidence in the literature for the beneficial effects of an approach to surgery in which two attending physicians rather than a single attending physician perform surgery for and oversee the surgical care of a single patient in a dual-attending care model. The authors developed a dual-attending care collaboration in August 2017 in which a neurosurgeon and an orthopedic surgeon mutually operated on patients with ASD. Read More

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http://dx.doi.org/10.3171/2020.3.SPINE2016DOI Listing

The role of concomitant chemoradiotherapy in AJCC 7 edition T1-2N1 oropharyngeal carcinoma in the human papillomavirus era.

Oral Oncol 2020 Jul 7;110:104882. Epub 2020 Jul 7.

Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States. Electronic address:

Background: Radiotherapy (RT) without chemotherapy is considered a standard of care for the management of American Joint Committee on Cancer (AJCC) 7th edition (7E) T1-2N1 oropharyngeal squamous cell carcinoma (OPSCC). Recent data suggests concurrent chemoradiation (CCRT) may benefit these patients but did not include human papillomavirus (HPV) status. Given the radiosensitivity differences between HPV-positive versus HPV-negative OPSCC, the effect of chemotherapy may differ in these patients. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104882DOI Listing

Race and cultural factors in an RCT of prolonged exposure and sertraline for PTSD.

Behav Res Ther 2020 Jun 29;132:103690. Epub 2020 Jun 29.

Center for Anxiety and Traumatic Stress, University of Washington, Department of Psychology, Guthrie Hall, Box 351525, Seattle, WA, 98195-1525, USA.

The efficacy of treatments for posttraumatic stress disorder (PTSD) among African Americans is less clear given underrepresentation in clinical research. Additionally, intervention research examining race has typically not considered within-group heterogeneity, such as acculturation, ethnic identity, and cultural attitudes. In a randomized controlled trial, African American (n = 43) and Caucasian (n = 130) individuals received prolonged exposure (PE) or sertraline for PTSD, comparing: treatment response, retention, and treatment beliefs and preferences. Read More

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http://dx.doi.org/10.1016/j.brat.2020.103690DOI Listing

The efficacy of adding short-term psychodynamic psychotherapy to antidepressants in the treatment of depression: A systematic review and meta-analysis of individual participant data.

Clin Psychol Rev 2020 Jun 26;80:101886. Epub 2020 Jun 26.

Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Purpose: We examined the efficacy of adding short-term psychodynamic psychotherapy (STPP) to antidepressants in the treatment of depression by means of a systematic review and meta-analysis of individual participant data, which is currently considered the most reliable method for evidence synthesis.

Results: A thorough systematic literature search resulted in 7 studies comparing combined treatment of antidepressants and STPP versus antidepressant mono-therapy (n = 3) or versus antidepressants and brief supportive psychotherapy (n = 4). Individual participant data were obtained for all these studies and totaled 482 participants. Read More

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http://dx.doi.org/10.1016/j.cpr.2020.101886DOI Listing

Posterior Latissimus Dorsi Transfer For Massive Irreparable Posterior-superior Rotator Cuff Tears: Does it Work In The Elderly Population? A Comparative Study Between Two Age Groups (≤55 Versus ≥75 Years old).

J Shoulder Elbow Surg 2020 Jul 7. Epub 2020 Jul 7.

Hôpital Ambroise Pare, Shoulder Department, Paris, France.

Hypothesis And/or Background: Management of irreparable postero-superior rotator cuff tears (RCT) presents a significant challenge to the shoulder surgeons. Previous studies on latissimus dorsi transfer (LDT) have demonstrated good to excellent outcomes in younger patients but this indication is debatable in the elderly. The main objective of this study was to compare the results of LDT in a group of patient under 55 versus a group over 75 years of age. Read More

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http://dx.doi.org/10.1016/j.jse.2020.06.018DOI Listing

Efficacy of the modified frailty index and the modified Charlson comorbidity index in predicting complications in patients undergoing operative management of proximal humerus fracture.

J Shoulder Elbow Surg 2020 Jul 7. Epub 2020 Jul 7.

Department of Orthopaedic Surgery, Loma Linda University Medical Center, Loma Linda, CA, USA. Electronic address:

Background: Comorbidity indices such as the 5-factor modified Frailty Index (mFI-5) and modified Charlson Comorbidity Index (mCCI) are widely used in outcomes research.

Methods: 3,893 patients who underwent total shoulder arthroplasty (TSA, n=975), hemiarthroplasty (HA, n=495), or open reduction and internal fixation (ORIF, n=2,423) for the treatment of proximal humerus fracture (PHFx) from 2005-2017 were identified from the National Surgical Quality Improvement Program (NSQIP) database. Data regarding demographics, comorbidities, ASA class, and postoperative complications were collected, and the mFI-5 and mCCI were calculated for each case. Read More

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http://dx.doi.org/10.1016/j.jse.2020.06.014DOI Listing

Arthroscopic superior capsule reconstruction with Teflon felt synthetic graft for irreparable massive rotator cuff tears: Clinical and radiographic results at minimum 2-year follow-up.

J Shoulder Elbow Surg 2020 Jul 7. Epub 2020 Jul 7.

Department of Orthopedic Surgery, Osaka Medical College, Takatsuki, Osaka, Japan. Electronic address:

Background: Superior capsule reconstruction (SCR) was developed to improve shoulder function and relieve pain in patients with irreparable rotator cuff tears. Here, we investigated the clinical and radiographic outcomes and postoperative complications of SCR using a Teflon graft for reconstruction.

Methods: Thirty-five consecutive patients with irreparable rotator cuff tears underwent SCR with Teflon grafts. Read More

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http://dx.doi.org/10.1016/j.jse.2020.06.022DOI Listing

Correlation of Patient Reported Outcome Measurement Information System (PROMIS) with American Shoulder and Elbow Surgeon (ASES), and Constant (CS) scores in Idiopathic Adhesive Capsulitis.

J Shoulder Elbow Surg 2020 Jul 7. Epub 2020 Jul 7.

NYU Langone Health, New York, NY, USA. Electronic address:

Purpose: To correlate the Patient Reported Outcomes Measurement Information System Upper Extremity (PROMIS UE) score with preexisting validated outcomes scores, American Shoulder and Elbow Surgeons score (ASES), and Constant score (CS) in patients with idiopathic adhesive capsulitis (AC).

Methods: Patients with a clinical diagnosis of idiopathic AC ("freezing" or "frozen" phases) who agreed to complete the ASES, CS, and PROMIS UE scores during their office visit were included in this study. Trained researchers performed the objective clinical assessments on the included patients. Read More

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http://dx.doi.org/10.1016/j.jse.2020.05.040DOI Listing

DIAGNOSIS AND MANAGEMENT OF UROLUME URETHRAL STENT COMPLICATIONS USING ULTRASONOGRAPHY AND MAGNETIC RESONANCE IMAGING.

Urology 2020 Jul 7. Epub 2020 Jul 7.

Department of Urology, Medical University of Gdansk, Poland. Electronic address:

The UroLume urethral stent (American Medical Systems) was introduced to the market in 1988 for management of male urethral stricture and benign prostatic hyperplasia [1]. However, recent reports in the literature showed long-term complications, including: urethral restenosis, urethral pain, recurrent urinary tract infections and stent migration. Therefore, UroLume's efficacy in managing bladder outlet obstruction had to be weighed against an alarmingly high rate of long-term complications [2,3]. Read More

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http://dx.doi.org/10.1016/j.urology.2020.06.043DOI Listing

Biotransformation of Contraceptive Drug Desogestrel with Cunninghamella elegans, and Anti-inflammatory Activity of its Metabolites.

Steroids 2020 Jul 7:108694. Epub 2020 Jul 7.

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia. Electronic address:

Biotransformation of an orally active contraceptive drug, desogestrel (1), with Cunninghamella elegans yielded a new metabolite 2 (13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-17β-ol-3,6-dione), along with five known metabolites, i.e., 3 (13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-3β,6β,17β-triol), 4 (13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-6β,17β-diol-3-one), 5 (13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-17β-ol-3-one), 6 (13β-ethyl-11-epoxy-18,19-dinor-17α-pregn-4-en-20-yn-17β-ol-3-one), and 7 (13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-10β,17β-diol-3-one). Read More

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http://dx.doi.org/10.1016/j.steroids.2020.108694DOI Listing

Infection as a trigger for cardiovascular disease.

Authors:
Joseph S Alpert

Am J Med 2020 Jul 7. Epub 2020 Jul 7.

Professor of Medicine, University of Arizona Department of Medicine, Tucson AZ; Editor in Chief, The American Journal of Medicine, 1501 N. Campbell Avenue, Tucson, AZ 85724-5037. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2020.07.001DOI Listing

COVID-19 and Kidney Transplantation: Results from the TANGO International Transplant Consortium.

Am J Transplant 2020 Jul 10. Epub 2020 Jul 10.

Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Kidney transplant recipients may be at high risk of developing critical COVID-19 illness due to chronic immunosuppression and comorbidities. We identified hospitalized adult kidney transplant recipients at 12 transplant centers in the US, Italy and Spain who tested positive for COVID-19. Clinical presentation, laboratory values, immunosuppression and treatment strategies were reviewed and predictors of poor clinical outcomes were determined through multivariable analyses. Read More

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http://dx.doi.org/10.1111/ajt.16185DOI Listing

Intranasal fentanyl spray versus intravenous opioids for the treatment of severe pain in patients with cancer in the emergency department setting: A randomized controlled trial.

PLoS One 2020 10;15(7):e0235461. Epub 2020 Jul 10.

Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

Objective: Intranasal fentanyl (INF) quickly and noninvasively relieves severe pain, whereas intravenous hydromorphone (IVH) reliably treats severe cancer pain but requires vascular access. The trial evaluated the efficacy of INF relative to IVH for treating cancer patients with severe pain in an emergency department (ED) setting.

Methods: We randomized 82 patients from a comprehensive cancer center ED to receive INF (n = 42) or IVH (n = 40). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235461PLOS

Characterizing the impact of an exotic soybean line on elite cultivar development.

PLoS One 2020 10;15(7):e0235434. Epub 2020 Jul 10.

Department of Crop and Soil Sciences, Institute of Plant Breeding, Genetics and Genomics, University of Georgia, Athens, GA, United States of America.

The genetic diversity of North American soybean cultivars has been largely influenced by a small number of ancestors. High yielding breeding lines that possess exotic pedigrees have been developed, but identifying beneficial exotic alleles has been difficult as a result of complex interactions of yield alleles with genetic backgrounds and environments as well as the highly quantitative nature of yield. PI 416937 has been utilized in the development of many high yielding lines that have been entered into the USDA Southern States Uniform Tests over the past ~20 years. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235434PLOS

Antibiotic prescription patterns for treating dental infections in children among general and pediatric dentists in teaching institutions of Karachi, Pakistan.

PLoS One 2020 10;15(7):e0235671. Epub 2020 Jul 10.

Department of Community Medicine, Baqai Medical University, Karachi, Pakistan.

Background: Antibiotics are regularly prescribed by dental professionals in their practice, for the purpose of dental treatment as well as for the prevention of infection. The inappropriate use of antibiotics is a significant factor in the rise of antibiotic resistance. There is an immediate need for the advancement of prescribing guidelines and instructive polices to encourage the rational and appropriate utilization of medications especially antibiotics in dentistry. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235671PLOS

Local Injection of Botulinum Toxin Type A to Prevent Postoperative Scar: Comment.

J Craniofac Surg 2020 Jul 1. Epub 2020 Jul 1.

Division of Plastic and Reconstructive Surgery American University of Beirut Medical Center Beirut, Lebanon Division of Plastic and Reconstructive Surgery, Trad Hospital Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1097/SCS.0000000000006664DOI Listing

Association of Obstetric and Neonatal Outcomes With Deviation From Guidelines for Gestational Carriers.

Obstet Gynecol 2020 Jul 9. Epub 2020 Jul 9.

Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, the Division of Medical Genetics, Department of Pediatrics, the Department of Obstetrics, Gynecology & Reproductive Sciences, and the Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, California; and the University of Utah Center for Reproductive Medicine and the Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, University of Utah Health, Salt Lake City, Utah.

Objective: To evaluate whether deviation from American Society for Reproductive Medicine (ASRM) safety guidelines for women who are gestational carriers is associated with increased risk of severe obstetric and perinatal morbidity and mortality.

Methods: This is a cross-sectional study of births from gestational carrier pregnancies in Utah from 2009 to 2018 with data collected from birth certificates. Deviations from ASRM guidelines include women aged younger than 21 years or older than 45 years, nulliparity, prior stillbirth, tobacco or percutaneous drug use, more than five prior deliveries, more than three prior cesarean deliveries, major comorbidities, and mental health conditions. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003918DOI Listing

Learning Delegation Through Role-Play: A Problem-Based Learning Activity for Nursing Students.

Authors:
Susan A Seibert

Nurs Educ Perspect 2020 Jul 7. Epub 2020 Jul 7.

About the Author Susan A. Seibert, DNP, RN, CNE, is an instructor at the University of Southern Indiana Department of Nursing, Evansville, Indiana. For more information, contact Dr. Seibert at

According to the American Nurses Association and National Council of State Boards of Nursing 2019 guidelines, teaching strategies are needed to engage students in the application of delegation knowledge and skills. Students need opportunities to gain experience with delegation decision-making in a safe, risk-free environment. This article describes the instructional design and evaluation of an innovative role-play activity to engage senior-level nursing students in delegation decision-making. Read More

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http://dx.doi.org/10.1097/01.NEP.0000000000000692DOI Listing

Adoption of Lean management and hospital performance: Results from a national survey.

Health Care Manage Rev 2020 Jul 1. Epub 2020 Jul 1.

Thomas G. Rundall, PhD, is Henry J. Kaiser Professor of Health Policy and Management, Emeritus and Co-director, Center for Lean Engagement and Research in Healthcare, School of Public Health, University of California, Berkeley. E-mail: Stephen M. Shortell, PhD, MPH, MBA, is Blue Cross of California Distinguished Professor of Health Policy and Management, Emeritus and Co-director, Center for Lean Engagement and Research in Healthcare, School of Public Health, University of California, Berkeley. Janet C. Blodgett, MS, is Senior Data Analyst and Project Director, Center for Lean Engagement and Research in Healthcare, School of Public Health, University of California, Berkeley. Rachel Mosher Henke, PhD, is Senior Director, Evaluation and Economic Research, IBM Watson Health, Cambridge, Massachusetts. David Foster, PhD, MPH, is Principal Scientist, IBM Watson Health, Cambridge, Massachusetts.

Background: Despite being adopted by a large number of hospitals, the relationship between Lean management and hospital performance is mixed and not well understood.

Purpose: We examined the relationships between Lean and hospital financial performance, patient outcomes, and patient satisfaction in a large national sample of hospitals, controlling for relevant organizational and market factors.

Methodology/approach: A mixed effects linear regression analysis was performed to assess the relationships between adoption of Lean and 10 measures of hospital performance using data from 1,152 hospitals that responded to the 2017 National Survey of Lean/Transformational Performance Improvement in Hospitals. Read More

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http://dx.doi.org/10.1097/HMR.0000000000000287DOI Listing

Defining the "Tipping Point" to Success as a Surgeon-Scientist: An Analysis of Applicants and Awardees of the American College of Surgeons Jacobson Promising Investigator Award.

Ann Surg 2020 Jul 7. Epub 2020 Jul 7.

Surgical Research Committee, American College of Surgeons, Chicago, IL.

Background: Since 2005, the American College of Surgeons has administered the Jacobson Promising Investigator Award (JPIA), which recognizes surgeon-scientists at the "tipping point" of their research careers.

Objective: We retrospectively reviewed JPIA applicants to identify factors associated with selection for the award and future research success.

Methods: Profiles were reviewed for all applicants between 2008 and 2018, at the time of application and as of 2019. Read More

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http://dx.doi.org/10.1097/SLA.0000000000004142DOI Listing

Benchmarking Accomplishments of Leaders in American Surgery and Justification for Enhancing Diversity and Inclusion.

Ann Surg 2020 Jul 7. Epub 2020 Jul 7.

Department of Surgery, University of Alabama-Birmingham (UAB), Birmingham, Alabama.

Objective: To comprehensively assess the level of achievement and demographics of national surgical society presidents.

Background: Data on the accomplishments needed to rise to positions of national surgical leadership is scarce and merit alone does not always yield such opportunities. Recognizing the shortcomings of sex and ethnic diversity within academic surgical leadership, the American College of Surgeon (ACS), American Surgical Association (ASA), Association of Women Surgeons (AWS), and the Society of Black Academic Surgeons (SBAS) partnered to address these challenges by performing a comprehensive assessment of their presidents over the last 16 years. Read More

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http://dx.doi.org/10.1097/SLA.0000000000004151DOI Listing

"Virtual" Boot Camp: Orthopaedic Intern Education in the Time of COVID-19 and Beyond.

J Am Acad Orthop Surg 2020 Jul 7. Epub 2020 Jul 7.

From the Harvard Combined Orthopaedics Residency Program, Department of Orthopaedics, Massachusetts General Hospital (Dr. Bhashyam), and the Department of Orthopaedic Surgery, Brigham and Women's Hospital (Dr. Dyer), Boston, MA.

The emergence of COVID-19 as a viral pandemic in early 2020 resulted in notable changes to the daily practice, workflow, and education of orthopaedic residencies internationally. In particular, social distancing, residency restructuring, and redeployment to other services has increased heterogeneity in schedules and made the in-person gathering of trainees for education increasingly challenging. These changes may last until 2024 based on some mathematical models, resulting in notable disruptions to orthopaedic education, especially for junior residents. Read More

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http://dx.doi.org/10.5435/JAAOS-D-20-00559DOI Listing

Evaluating interventions to delay the progression of prediabetes to type-2 diabetes mellitus in an uninsured Hispanic population.

J Am Assoc Nurse Pract 2020 Jul 7. Epub 2020 Jul 7.

University of Alabama at Birmingham School of Nursing, Birmingham, Alabama.

Background: Diabetes is a chronic progressive disease affecting 34 million Americans. The Centers for Disease Control and Prevention estimates that 12.5% of people aged 20 years or older diagnosed with diabetes are Hispanic. Read More

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http://dx.doi.org/10.1097/JXX.0000000000000444DOI Listing

Equity in Genomics: A Brief Report on Cardiovascular Health Disparities in African American Adults.

J Cardiovasc Nurs 2020 Jul 1. Epub 2020 Jul 1.

Jewel Scott, PhD, MSN, FNP-C Doctoral Trainee, Duke University School of Nursing, Durham, North Carolina. Lakeshia Cousin, PhD, APRN Postdoctoral Fellow, Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida. Jennifer Woo, PhD, CNM/WHNP, FACNM Assistant Professor, Texas Women's University, Dallas. Rosa Gonzalez-Guarda, PhD, MPH, RN, CPH, FAAN Associate Professor, Duke University School of Nursing, Durham, North Carolina. Leigh Ann Simmons, PhD, MFT Professor and Chair, Department of Human Ecology, University of California, Davis.

Background: African Americans are more likely to die from cardiovascular disease (CVD) than all other populations in the United States. Although technological advances have supported rapid growth in applying genetics/genomics to address CVD, most research has been conducted among European Americans. The lack of African American representation in genomic samples has limited progress in equitably applying precision medicine tools, which will widen CVD disparities if not remedied. Read More

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http://dx.doi.org/10.1097/JCN.0000000000000725DOI Listing

Sex Differences in Prehospital Delay in Patients With Acute Stroke: A Systematic Review.

J Cardiovasc Nurs 2020 Jul 3. Epub 2020 Jul 3.

Wiphawadee Potisopha, MSN, RN PhD Student, College of Nursing, University of Illinois at Chicago. Karen M. Vuckovic, PhD, APRN, ACNS-BC, FAHA Assistant Professor, College of Nursing, University of Illinois at Chicago and Adjunct Faculty, College of Medicine, University of Illinois at Chicago. Holli A. DeVon, PhD, RN, FAHA, FAAN Professor and Associate Dean for Research, School of Nursing, University of California, Los Angeles. Chang G. Park, PhD Assistant Professor, College of Nursing, University of Illinois at Chicago. Patricia E. Hershberger, PhD, APRN, FNP-BC FAAN Associate Professor, College of Nursing, University of Illinois at Chicago, and Affiliate Professor, College of Medicine, University of Illinois at Chicago.

Background: In 2009, the window from symptom onset to administration of tissue plasminogen activator for acute ischemic stroke was extended from 3 to 4.5 hours. Yet no systematic review has addressed prehospital delay by sex for stroke symptoms since this change. Read More

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http://dx.doi.org/10.1097/JCN.0000000000000715DOI Listing

Nutrition and physical activity recommendations from the United States and European cardiovascular guidelines: a comparative review.

Curr Opin Cardiol 2020 Jul 6. Epub 2020 Jul 6.

The Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Purpose Of Review: A healthy lifestyle throughout one's lifespan is the core foundation for both primary and secondary prevention of cardiovascular disease (CVD). Risk-based decisions for pharmacological therapy is added on-top of lifestyle management. Thus, understanding lifestyle-based recommendations is central to CVD prevention. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000763DOI Listing

Nivicolous Trichiales from the austral Andes: unexpected diversity including two new species.

Mycologia 2020 Jul 10:1-28. Epub 2020 Jul 10.

Real Jardín Botánico, Consejo Superior de Investigaciones Científicas , Plaza de Murillo 2, 28014 Madrid, Spain.

Nivicolous myxomycetes are a group of amoebozoan protists dependent on long-lasting snow cover worldwide. Recent fine-scale analysis of species diversity from the austral Andes revealed high intraspecific variability of most taxa, suggesting independent evolutionary processes and significant differences in species compositions between the Northern (NH) and Southern (SH) Hemispheres. The present study is the second part of this analysis based on representatives of Trichiales. Read More

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http://dx.doi.org/10.1080/00275514.2020.1759978DOI Listing

Large population-based study using the SEER database: is endoscopic resection appropriate for early gastric cancer patients in the United States?

Scand J Gastroenterol 2020 Jul 10:1-9. Epub 2020 Jul 10.

Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.

Aim: To investigate whether endoscopic treatment is applicable to American patients and explores the predictors of lymph node metastasis (LNM) in early gastric cancer (EGC).

Methods: Patients with EGC confined to either mucosa (T1a,  = 1799) and submucosa (T1b,  = 1689) were identified from the Surveillance, Epidemiology, and End Result database. Multivariate logistic regression, Kaplan-Meier method, and univariate/multivariate Cox regression were used to assess the correlation between invasion depth and LNM or prognosis. Read More

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http://dx.doi.org/10.1080/00365521.2020.1786158DOI Listing

Investing in Tobacco Control: Twelve Years of MPOWER Measures and Progress in the Western Pacific Region.

Asian Pac J Cancer Prev 2020 Jul 1;21(S1):9-16. Epub 2020 Jul 1.

(Former) Division of NCD and Health though the Life-Course, World Health Organization Regional Office for the Western Pacific, Manila, Philippines.

Tobacco use has detrimental effects in the Western Pacific Region. The World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) came into effect in 2005 to address the global tobacco epidemic, and WHO introduced the MPOWER measures to facilitate implementation of key demand-reduction measures of the WHO FCTC at the country level. This paper provides an overview of progress made by countries within the Region since the introduction of the MPOWER measures 12 years ago, and examines challenges and threats hindering their further implementation. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.S1.9DOI Listing

Matrix-Induced Autologous Chondrycte Implantation for a Glenoid Chondral Defect: A Case Report.

JBJS Case Connect 2020 Apr-Jun;10(2):e0264

1Department of Orthopedic Surgery, University of Oklahoma, Oklahoma City, Oklahoma 2Oklahoma Sports and Orthopedics Institute, Norman, Oklahoma.

Case: We describe the case of a 33-year-old man who had a 1.5 × 2 cm chondral defect of the right glenoid that that was discovered on arthroscopy and was successfully treated with matrix-induced autologous chondrocyte implantation (MACI). At 2 years postoperatively, the patient's Constant score and American Shoulder and Elbow Surgeons (ASES) shoulder score improved by 44 and 51. Read More

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http://dx.doi.org/10.2106/JBJS.CC.19.00264DOI Listing

Breastfeeding and risk of respiratory allergies and asthma in children: Seeing things from different perspective.

Authors:
J Dimnjakovic

Acta Paediatr 2020 Jul 10. Epub 2020 Jul 10.

Department of Medical Informatics and Biostatistics, Croatian Institute of Public Health, Zagreb, Croatia.

With great interest I read the study in Acta Paediatrica conducted by Bigman, longitudinal study examining associations between breastfeeding and respiratory allergies and types of asthma in American children. Bigman concluded "the study provided evidence that exclusive breastfeeding for the first 3 months may reduce the risk of respiratory allergies and asthma in children 6 years of age". This is an important study because it sheds light on the topic of relationship between breastfeeding and asthma since breastfeeding impact on asthma development is generally considered uncertain. Read More

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http://dx.doi.org/10.1111/apa.15470DOI Listing

Home Language and Literacy Environments and Early Literacy Trajectories of Low-Socioeconomic Status Chilean Children.

Child Dev 2020 Jul 10. Epub 2020 Jul 10.

Pontificia Universidad Católica de Chile.

This study used Latent Class Analysis to identify groups of children exposed to similar Home Language and Literacy Environments (HLLE) and explored whether belonging to a given HLLE group was related to children's language and early literacy growth from prekindergarten to kindergarten. Participants were 1,425 Chilean mothers and their children (M  = 52.52 months at baseline) from low-socioeconomic status households. Read More

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http://dx.doi.org/10.1111/cdev.13382DOI Listing

Optimization of therapeutic strategy for p16-positive oropharyngeal squamous cell carcinoma: Multi-institutional observational study based on the national head and neck cancer registry of Japan.

Cancer 2020 Jul 10. Epub 2020 Jul 10.

Department of Otorhinolaryngology, Kindai University Nara Hospital, Nara, Japan.

Background: Although the American Joint Committee on Cancer TNM classification has been amended to include human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) as an independent entity, to the authors' knowledge the optimized de-escalating treatment modality has not been established to date.

Methods: The authors conducted a retrospective, nationwide, observational study in patients with HPV-related OPSCC who were treated from 2011 to 2014 in Japan to determine the best treatment modality.

Results: A total of 688 patients who were newly diagnosed with HPV-related OPSCC who were treated with curative intent at 35 institutions and had coherent clinical information and follow-up data available were included in the current study. Read More

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http://dx.doi.org/10.1002/cncr.33062DOI Listing

Impact of the coronavirus disease 2019 (COVID-19) pandemic on pediatric oncology care in the Middle East, North Africa, and West Asia Region: A report from the Pediatric Oncology East and Mediterranean (POEM) Group.

Cancer 2020 Jul 10. Epub 2020 Jul 10.

Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, Tennessee.

Background: Childhood cancer is a highly curable disease when timely diagnosis and appropriate therapy are provided. A negative impact of the coronavirus disease 2019 (COVID-19) pandemic on access to care for children with cancer is likely but has not been evaluated.

Methods: A 34-item survey focusing on barriers to pediatric oncology management during the COVID-19 pandemic was distributed to heads of pediatric oncology units within the Pediatric Oncology East and Mediterranean (POEM) collaborative group, from the Middle East, North Africa, and West Asia. Read More

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http://dx.doi.org/10.1002/cncr.33075DOI Listing

Association of Hospital-Level Acute Resuscitation and Postresuscitation Survival With Overall Risk-Standardized Survival to Discharge for In-Hospital Cardiac Arrest.

JAMA Netw Open 2020 Jul 1;3(7):e2010403. Epub 2020 Jul 1.

Saint Luke's Mid America Heart Institute and the University of Missouri, Kansas City.

Importance: Survival after in-hospital cardiac arrest depends on 2 distinct phases: responsiveness and quality of the hospital code team (ie, acute resuscitation phase) and intensive and specialty care expertise (ie, postresuscitation phase). Understanding the association of these 2 phases with overall survival has implications for design of in-hospital cardiac arrest quality measures.

Objective: To determine whether hospital-level rates of acute resuscitation survival and postresuscitation survival are associated with overall risk-standardized survival to discharge for in-hospital cardiac arrest. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.10403DOI Listing

The mechanism of osmotically-induced sealing of cardiac t-tubules.

Am J Physiol Heart Circ Physiol 2020 Jul 10. Epub 2020 Jul 10.

Molecular and Integrative Physiology, University of Michigan-Ann Arbor, United States.

Cardiac t-tubules undergo significant remodeling in various pathological and experimental conditions, which can be associated with mechanical or osmotic stress. In particular, it has been shown that removal of hyposmotic stress can lead to sealing of t-tubules. However, the mechanisms underlying the sealing process remain essentially unknown. Read More

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http://dx.doi.org/10.1152/ajpheart.00573.2019DOI Listing

The American Association for the Surgery of Trauma Renal Grading System: Should Segmental Kidney Infarction be Classified as a Grade IV Injury?

J Urol 2020 Jul 10:101097JU0000000000001240. Epub 2020 Jul 10.

Division of Urology, Department of Surgery, University of Utah, Salt Lake City, Utah.

Purpose: In 2018, the American Association for the Surgery of Trauma (AAST) revised renal injury grading. One change was inclusion of segmental kidney infarction (SKI) under grade-IV injuries. We aimed to assess how SKI will change the scope of grade-IV injuries and compare bleeding control interventions in those with and without isolated SKI (iSKI). Read More

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http://dx.doi.org/10.1097/JU.0000000000001240DOI Listing

Efficacy and Safety of Canakinumab in sJIA Patients with and without Fever at Baseline: Results from an Open-label, Active Treatment Extension Study.

Arthritis Rheumatol 2020 Jul 10. Epub 2020 Jul 10.

IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy.

Objective: To evaluate the long-term efficacy, safety of canakinumab and explore prediction of response in systemic juvenile idiopathic arthritis (sJIA) patients with and without fever at treatment initiation.

Methods: At enrollment, active sJIA patients (2-<20 years) started open-label canakinumab (4mg/kg every 4 weeks [q4w] subcutaneously). Efficacy measures included the adapted JIA American College of Rheumatology (aJIA-ACR) criteria, Juvenile Arthritis Disease Activity Score (JADAS), and clinically inactive disease (CID)/clinical remission on medication (CR), evaluated by either JADAS (CID /CR ) or ACR criteria (CID /CR ). Read More

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http://dx.doi.org/10.1002/art.41436DOI Listing

COVID-19 pandemic and impact on cancer clinical trials: An academic medical center perspective.

Cancer Med 2020 Jul 10. Epub 2020 Jul 10.

UC Cancer Center, University of Cincinnati Medical Center, Cincinnati, OH, USA.

The COVID-19 pandemic changed health-care operations around the world and has interrupted standard clinical practices as well as created clinical research challenges for cancer patients. Cancer patients are uniquely susceptible to COVID-19 infection and have some of the worst outcomes. Importantly, cancer therapeutics could potentially render cancer patients more susceptible to demise from COVID-19 yet the poor survival outcome of many cancer diagnoses outweighs this risk. Read More

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http://dx.doi.org/10.1002/cam4.3292DOI Listing

The endocranium and trophic ecology of Velociraptor mongoliensis.

J Anat 2020 Jul 10. Epub 2020 Jul 10.

Oxford University Museum of Natural History, University of Oxford, Oxford, UK.

Neuroanatomical reconstructions of extinct animals have long been recognized as powerful proxies for palaeoecology, yet our understanding of the endocranial anatomy of dromaeosaur theropod dinosaurs is still incomplete. Here, we used X-ray computed microtomography (µCT) to reconstruct and describe the endocranial anatomy, including the endosseous labyrinth of the inner ear, of the small-bodied dromaeosaur, Velociraptor mongoliensis. The anatomy of the cranial endocast and ear were compared with non-avian theropods, modern birds, and other extant archosaurs to establish trends in agility, balance, and hearing thresholds in order to reconstruct the trophic ecology of the taxon. Read More

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http://dx.doi.org/10.1111/joa.13253DOI Listing

Cinematherapy with African American couples.

J Clin Psychol 2020 Jul 10. Epub 2020 Jul 10.

Division of Psychology and Counseling, Governors State University, University Park, Illinois, USA.

Cinematherapy is the use of movies as an intervention with clients. When done well, it is used to evoke and process emotion, psychoeducate, increase empathy, and problem-solve. However, there is no literature on utilizing movies as an intervention with African American couples. Read More

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http://dx.doi.org/10.1002/jclp.22999DOI Listing

Triggers of Primary Headaches: Issues and Pathways Forward.

Authors:
Paul R Martin

Headache 2020 Jul 10. Epub 2020 Jul 10.

Department of Psychiatry, Monash University, Melbourne, VIC, Australia.

The triggers of primary headaches have considerable significance for our understanding and management of headache and migraine. Triggers explain the variance in headaches - why they occur when they do. Trigger management is generally viewed as an important component of a comprehensive treatment approach for headaches. Read More

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http://dx.doi.org/10.1111/head.13901DOI Listing

Greetings from the front lines, when all the world is the front.

Authors:
Fadlo R Khuri

Cancer 2020 Jul 10. Epub 2020 Jul 10.

The American University of Beirut, New York, New York.

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http://dx.doi.org/10.1002/cncr.33052DOI Listing

Cumulative incidence and diagnosis of SARS-CoV-2 infection in New York.

Ann Epidemiol 2020 Jun 16. Epub 2020 Jun 16.

New York State Department of Health, Albany NY.

Purpose: New York State (NYS) is an epicenter of the SARS-CoV-2 pandemic in the United States. Reliable estimates of cumulative incidence in the population are critical to tracking the extent of transmission and informing policies.

Methods: We conducted a statewide seroprevalence study among a 15,101 patron convenience sample at 99 grocery stores in 26 counties throughout NYS. Read More

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http://dx.doi.org/10.1016/j.annepidem.2020.06.004DOI Listing

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice.

Elife 2020 Jul 10;9. Epub 2020 Jul 10.

Pathology, University of Washington, Seattle, United States.

Diastolic dysfunction is a prominent feature of cardiac aging in both mice and humans. We show here that 8-week treatment of old mice with the mitochondrial targeted peptide SS-31 (elamipretide) can substantially reverse this deficit. SS-31 normalized the increase in proton leak and reduced mitochondrial ROS in cardiomyocytes from old mice, accompanied by reduced protein oxidation and a shift towards a more reduced protein thiol redox state in old hearts. Read More

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http://dx.doi.org/10.7554/eLife.55513DOI Listing

How coloniality shapes the making of Latin American psychologists: ethnographic evidence from Ecuador.

Int Rev Psychiatry 2020 Jul 10:1-11. Epub 2020 Jul 10.

Division of Psychiatry, University College London, London, UK.

This paper provides ethnographic evidence on how coloniality shapes the making of Latin American psychologists. A critical ethnography was conducted at a psychology training institution in Ecuador, consisting of twelve months of participant observation; forty-one semi-structured interviews; and analysis of academic discourse, photos, videos and relevant social media content. The research was guided by the tradition of Critical Psychology - specifically Liberation Psychology - and Critical Discourse Analysis. Read More

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http://dx.doi.org/10.1080/09540261.2020.1761777DOI Listing

Survey of Microsurgery Training Availability in US Urology Residency Programs.

World J Mens Health 2020 May 18. Epub 2020 May 18.

Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA.

Purpose: The Accreditation Council of Graduate Medical Education (ACGME) establishes surgical minimum numbers of cases for urologic training. Currently there is not a requirement for microsurgery, likely from a belief that programs do not offer exposure. In an effort to evaluate the availability of microsurgery training among urology residency programs we surveyed the programs. Read More

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http://dx.doi.org/10.5534/wjmh.190162DOI Listing

The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic Review.

World J Mens Health 2020 Jun 25. Epub 2020 Jun 25.

Department of Urology, Centro Universitario em Saude do ABC, Santo André, Brazil.

The advent of intracytoplasmic sperm injection (ICSI) has changed the human reproduction landscape by overcoming several limitations related to both male and female infertility factors. However, despite the development of new technologies, the live-birth rate with ICSI has not exceeded 30%. In order to improve assisted reproductive technology outcomes, advanced sperm function analysis have gained increased attention and the effects of sperm DNA fragmentation (SDF) on assisted reproduction success are being extensively studied. Read More

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http://dx.doi.org/10.5534/wjmh.200084DOI Listing

Generation of transgenic mice that conditionally express microRNA miR-145.

Genesis 2020 Jul 10:e23385. Epub 2020 Jul 10.

Center for Cardiovascular Research and The Heart Center, Nationwide Children's Hospital, Columbus, Ohio, USA.

MicroRNAs are modulators of cellular phenotypes and their functions contribute to development, homeostasis, and disease. miR-145 is a conserved microRNA that has been implicated in regulating an array of phenotypes. These include supporting smooth muscle differentiation, repression of stem cell pluripotency, and inhibition of tumor growth and metastasis. Read More

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http://dx.doi.org/10.1002/dvg.23385DOI Listing

Aster-C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1.

EMBO Rep 2020 Jul 9:e49898. Epub 2020 Jul 9.

Department of Pharmacology, Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Nutrient sensing by the mTOR complex 1 (mTORC1) requires its translocation to the lysosomal membrane. Upon amino acids removal, mTORC1 becomes cytosolic and inactive, yet its precise subcellular localization and the mechanism of inhibition remain elusive. Here, we identified Aster-C as a negative regulator of mTORC1 signaling. Read More

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http://dx.doi.org/10.15252/embr.201949898DOI Listing