2,645 results match your criteria Amenorrhea Secondary


Neuroendocrine mechanisms of reproduction.

Handb Clin Neurol 2020 ;171:3-23

Department of Obstetrics and Gynecology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United States. Electronic address:

The neuroendocrinology of reproduction focuses on the neuromodulation of gonadotropin-releasing hormone (GnRH), the ontogeny of the hypothalamic-pituitary-gonadal axis, and common reproductive events and conditions, namely, puberty, the menstrual cycle, and disorders of reproductive function. The core concept underpinning the neuroendocrinology of reproduction is neuroregulation of hypothalamic GnRH drive. In both men and women, reproductive function requires that GnRH input elicit appropriate secretion of follicle-stimulating hormone and luteinizing hormone from the anterior pituitary and that the gonads respond to such input appropriately. Read More

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http://dx.doi.org/10.1016/B978-0-444-64239-4.00001-1DOI Listing
January 2020

A Rare Pelvic "Mass-Querader": Acute Urinary Retention Secondary to Hematocolpos in a Preadolescent Patient.

Mil Med 2020 Jul 30. Epub 2020 Jul 30.

Department of Family Medicine, Mike O'Callaghan Military Medical Center, Nellis Air Force Base, 4700 N Las Vegas Blvd, Las Vegas, NV 89191.

We report a case of acute urinary retention in an adolescent female secondary to hematocolpos. A 13-year-old female presented to the emergency department with acute urinary retention and suprapubic abdominal pain for 24 hours. She denied menstruation or sexual history. Read More

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http://dx.doi.org/10.1093/milmed/usaa166DOI Listing

Hypopituitarism: A Rare but Often Neglected Condition.

Indian J Crit Care Med 2020 May;24(5):350-352

Department of General Medicine, All India Institute of Medical Sciences, Patna, Bihar, India.

Pituitary insufficiency is an uncommon disorder. The most common cause is compression due to a pituitary mass. Other causes include inflammatory damage and vascular injury like postpartum pituitary apoplexy. Read More

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http://dx.doi.org/10.5005/jp-journals-10071-23422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358872PMC

Iron deficiency induces female infertile in order to failure of follicular development in mice.

J Reprod Dev 2020 Jul 23. Epub 2020 Jul 23.

Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima, Hiroshima 727-0023, Japan.

Iron is important for many cellular functions, including ATP synthesis and cell proliferation. Insufficient of iron in the diet causes iron deficiency anemia (IDA), which often occurs in people living in the world. Since 50% of women with IDA show amenorrhea, the relationship of between iron deficiency and reproductive function was assessed using mice fed a low Fe diet (LFD). Read More

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http://dx.doi.org/10.1262/jrd.2020-074DOI Listing

Predictors of Response for Elagolix with Add-back Therapy in Women with Heavy Menstrual Bleeding Associated with Uterine Fibroids.

Am J Obstet Gynecol 2020 Jul 20. Epub 2020 Jul 20.

Mayo Clinic and Mayo Clinic Alix School of Medicine, Rochester, MN.

Background: Uterine fibroids are one of the most common neoplasms found among women globally with a prevalence of approximately 11 million women in the United States alone. The morbidity of this common disease is significant as it is the leading cause of hysterectomy and causes significant functional impairment for women of reproductive age. Factors, including age, body mass index (BMI), race, ethnicity, menstrual blood loss (MBL), fibroid location, and uterine and fibroid volume, influence the incidence of fibroids and severity of symptoms. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.07.032DOI Listing

Serum vitamin D levels and ovarian reserve markers in secondary amenorrhea patients: Is there a link?

Obstet Gynecol Sci 2020 Jul 30;63(4):521-528. Epub 2020 Jun 30.

Department of Obstetrics and Gynecology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

Objective: To investigate whether serum 25-hydroxyvitamin D [25(OH)D] level is associated with ovarian reserve markers in secondary amenorrhea (SA) patients.

Methods: Sixty-three women diagnosed with SA were recruited during 12 months from the initiation of this prospective observational study. Serum 25(OH)D levels, serum anti-Müllerian hormone (AMH) levels and antral follicle count (AFC) were estimated in study participants and ovarian reserve markers were compared between participants with vitamin D deficiency and those with normal vitamin D levels. Read More

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http://dx.doi.org/10.5468/ogs.20071DOI Listing

Treatment of Unfavorable Bleeding Patterns in Contraceptive Implant Users: A Randomized Controlled Trial.

Obstet Gynecol 2020 Aug;136(2):323-332

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon; the Department of Obstetrics and Gynecology, University of Hawaii, Honolulu, Hawaii; and the Department of Obstetrics & Gynecology, the Permanente Medical Group, San Leandro, California.

Objective: To evaluate whether a short course of tamoxifen decreases bothersome bleeding in etonogestrel contraceptive implant users.

Methods: In a 90-day, double-blind randomized control trial, we enrolled etonogestrel implant users with frequent or prolonged bleeding or spotting. A sample size of 40 per group (N=80) was planned to compare 10 mg tamoxifen or placebo twice daily for 7 days after 3 consecutive days of bleeding or spotting no more than once per 30 days (maximum three treatments). Read More

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http://dx.doi.org/10.1097/AOG.0000000000003896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395860PMC

Radiofrequency endometrial ablation with a novel endometrial tip for the management of heavy menstrual bleeding and abnormal uterine bleeding: a prospective study.

Int J Hyperthermia 2020 ;37(1):772-776

Department of Obstetrics and Gynecology, Chung-Ang University School of Medicine, Seoul, South Korea.

To evaluate the safety and efficacy of a radiofrequency ablation system with a novel endometrial tip (RFA-EMT) for the management of heavy menstrual bleeding (HMB) or abnormal uterine bleeding (AUB). This is a prospective study including a total of 38 premenopausal women with heavy menstrual bleeding (HMB) or abnormal uterine bleeding (AUB) that failed to respond to medical therapy. Hysteroscopic evaluation and curettage biopsy were performed just before the procedure. Read More

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http://dx.doi.org/10.1080/02656736.2020.1778196DOI Listing
January 2020

Combined transcervical endometrial resection and levonorgestrel device treatment compared to transcervical endometrial resection for abnormal uterine bleed.

Acta Obstet Gynecol Scand 2020 Jul 1. Epub 2020 Jul 1.

Department. of Obstetrics and Gynecology, Odense University Hospital, Odense, Denmark.

Introduction: Transcervical resection of the endometrium (TCRE) is a first line surgical treatment of abnormal uterine bleeding. However, many patients experience unsuccessful results, causing hysterectomy in up 17% of cases. The aim of this study was to describe the odds of hysterectomy in patients with abnormal uterine bleeding, treated with TCRE and Levonorgestrel intrauterine device (TCRE+LNG-IUD) or TCRE alone. Read More

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http://dx.doi.org/10.1111/aogs.13949DOI Listing

Puberty and Inhibin B in 35 Adolescents With Pituitary Stalk Interruption Syndrome.

Front Pediatr 2020 11;8:304. Epub 2020 Jun 11.

Fondation Ophtalmologique Adolphe de Rothschild and Université Paris Descartes, Paris, France.

In patients with pituitary stalk interruption syndrome (PSIS), long-term follow-up is necessary to address their gonadotrophic status. The objectives of this study were (1) to describe pubertal features of and (2) to assess the ability of serum inhibin B concentration to predict hypogonadotropic hypogonadism (HH) in patients with PSIS. This retrospective single-center study included 35 patients with PSIS and known gonadotrophic status for whom a serum sample preserved at -22°C (collected at initial evaluation or later) was available for measuring inhibin B by the same hormonal immunoassay method. Read More

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http://dx.doi.org/10.3389/fped.2020.00304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300191PMC

Transient hyperprolactinemia secondary to benzodiazepines: a case report.

Ann Biol Clin (Paris) 2020 Jun 22. Epub 2020 Jun 22.

Service de Biochimie et Génétique Moléculaire, CHU Hôpital G Montpied, Clermont-Ferrand, France.

Hyperprolactinemia is common and accounts for 20 to 25% of secondary amenorrhea causes. Here, we report a case of moderate hyperprolactinemia observed in a 40-year-old patient consulting for spaniomenorrhea and inguinal pain during a bartholinitis episode. After eliminating all known causes of hyperprolactinemia, alprazolam intake is finally assumed. Read More

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http://dx.doi.org/10.1684/abc.2020.1565DOI Listing

Fifteen-minute consultation: a structured approach to the child with primary amenorrhea.

Arch Dis Child Educ Pract Ed 2020 Jun 19. Epub 2020 Jun 19.

Paediatric Endocrinology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Puberty is a life-changing time in the life of a young person, with physical, psychological and social considerations. Amenorrhea is derived from Latin: a-'not', men-'month' and rhein-'flow', meaning absence of monthly flow. In medical terms, it is a symptom describing absence of menstruation. Read More

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http://dx.doi.org/10.1136/archdischild-2019-317999DOI Listing

Mayer-Rokitansky-Küster-Hauser syndrome with a solitary duplex kidney and anal stenosis: a rare case report.

J Pediatr Adolesc Gynecol 2020 Jun 16. Epub 2020 Jun 16.

Department of Geriatric Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Shandong, Jinan, China. Electronic address:

Background: To date, only 23 cases of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome with duplex kidney have been reported. We present the first reported case of MRKH syndrome with solitary duplex kidney and anal stenosis.

Case: A 17-year-old Chinese girl presented with primary amenorrhea and fully developed secondary sexual characteristics. Read More

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http://dx.doi.org/10.1016/j.jpag.2020.05.008DOI Listing

Efficacy and safety of vilaprisan in women with uterine fibroids: Data from the phase 2b randomized controlled trial ASTEROID 2.

Eur J Obstet Gynecol Reprod Biol 2020 May 31;252:7-14. Epub 2020 May 31.

Bayer AG, Müllerstraße 178, 13342, Berlin, Germany. Electronic address:

Objective: To assess the efficacy of vilaprisan compared with placebo in the management of the symptoms of uterine fibroids (UF), with a secondary objective to provide a descriptive comparison with ulipristal acetate.

Study Design: The randomized, parallel-group, double-blind, placebo- and active-controlled, multicenter ASTEROID 2 trial assessed the efficacy and safety of vilaprisan versus placebo and ulipristal acetate for two 12-week treatment periods in women with ≥1 UF experiencing heavy menstrual bleeding (HMB). The primary endpoint compared the efficacy of vilaprisan with placebo at 12 weeks, assessed as the absence of bleeding/spotting by bleeding diary. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.043DOI Listing

A Remarkable Response of Granulomatous Hypophysitis to Infliximab in a Patient With a Background of Crohn's Disease-A Case Report.

Front Endocrinol (Lausanne) 2020 29;11:350. Epub 2020 May 29.

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, United States.

Hypophysitis is primary or idiopathic or secondary to another disease process. The histologic subtypes of hypophysitis are lymphocytic, granulomatous, xanthomatous, xanthogranulomatous, or IgG4-related. Granulomatous hypophysitis is the second most common form and is characterized by multinucleated giant cells with granulomas and histiocytes. Read More

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http://dx.doi.org/10.3389/fendo.2020.00350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272571PMC

Secondary amenorrhoea - a consultation.

BMJ Sex Reprod Health 2020 Jun 16. Epub 2020 Jun 16.

Psychiatry, NHS Lothian, Edinburgh, UK.

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http://dx.doi.org/10.1136/bmjsrh-2020-200600DOI Listing

Study of frequency and types of chromosomal abnormalities in phenotypically female patients with amenorrhea in Eastern Indian population.

J Obstet Gynaecol Res 2020 Jun 8. Epub 2020 Jun 8.

Department of Genetics, Vivekananda Institute of Medical Sciences, Kolkata, India.

Aim: This comprehensive review article aims to comprehend the frequency and prevalence of chromosomal abnormalities in both primary amenorrhea (PA) and secondary amenorrhea (SA) cases and correlating it with their phenotypes, clinical features and hormonal profiles.

Methods: Research publications on prevalence of chromosomal abnormalities in both PA and SA cases worldwide and its etiology, clinical features, hormonal profiles; their correlation with chromosomal profiles were searched for on the internet, including general search engines and respective scientific sites. Only published, relevant and authentic data conducted on phenotypically female patients were considered. Read More

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http://dx.doi.org/10.1111/jog.14318DOI Listing

Osteoporosis in Premenopausal Women: A Clinical Narrative Review by the ECTS and the IOF.

J Clin Endocrinol Metab 2020 Aug;105(8)

Service of Bone Diseases, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland.

Context: Consensus regarding diagnosis and management of osteoporosis in premenopausal women (PW) is still lacking due to few studies carried out in this population.

Design: The European Calcified Tissue Society and the International Osteoporosis Foundation convened a working group to produce an updated review of literature published after 2017 on this topic.

Results: Fragility fractures in PW are rare and mostly due to secondary osteoporosis (ie, in presence of an underlying disease such as hormonal, inflammatory, or digestive disorders). Read More

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http://dx.doi.org/10.1210/clinem/dgaa306DOI Listing

Amenorrhea secondary to vismodegib: An adverse event to consider especially in female patients with Gorlin-Goltz syndrome.

Dermatol Ther 2020 May 7:e13527. Epub 2020 May 7.

Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy.

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http://dx.doi.org/10.1111/dth.13527DOI Listing

Low Bone Mineral Density in Elite Female Athletes With a History of Secondary Amenorrhea in Their Teens.

Clin J Sport Med 2020 05;30(3):245-250

Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.

Objective: To determine whether secondary amenorrhea during teenage years influences bone mineral density (BMD) in female athletes in their 20s.

Design: Original research.

Setting: Japan Institute of Sports Sciences. Read More

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http://dx.doi.org/10.1097/JSM.0000000000000571DOI Listing

Novel Mutation in the Hemojuvelin Gene (HJV) in a Patient with Juvenile Hemochromatosis Presenting with Insulin-dependent Diabetes Mellitus, Secondary Hypothyroidism and Hypogonadism.

Am J Case Rep 2020 Apr 24;21:e923108. Epub 2020 Apr 24.

Endocrinology Unit, University Hospital of the Federal University of Maranhão (HUUFMA), São Luís, Brazil.

BACKGROUND Juvenile hemochromatosis is a rare genetic disease that leads to intense iron accumulation. The disease onset usually occurs before the third decade of life and causes severe dysfunction in various organs. The most classical clinical findings are hypogonadotropic hypogonadism, cardiomyopathy, liver fibrosis, glycemic changes, arthropathy and skin pigmentation. Read More

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http://dx.doi.org/10.12659/AJCR.923108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200091PMC

A young girl with right ovarian torsion and left ovarian ectopy.

Ital J Pediatr 2020 Apr 23;46(1):51. Epub 2020 Apr 23.

Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.

Background: Mayer-Rokitansky-Küster-Hauser (MRKHS) syndrome refers to congenital hypoplasia/aplasia of the uterus, the cervix and the upper 2/3 of the vagina, in females with normal ovaries and fallopian tubes, secondary sexual characteristics and 46 XX karyotype. This condition originates from abnormal development of Müller's paramesonephric ducts in the early stages of embryonic development. Kidney agenesis or malformations are the most commonly associated with unilateral kidney agenesis. Read More

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http://dx.doi.org/10.1186/s13052-020-0811-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181485PMC

Endometrial and cervical osseous metaplasia with extramedullary haematopoiesis presenting as amenorrhea: Report of three cases.

Indian J Pathol Microbiol 2020 Apr-Jun;63(2):295-297

Department of Pathology, All India Institute of Medical Sciences, Patna, India.

Endometrial and cervical osseous metaplasia (OM) is a rare phenomenon seen mostly in reproductive age group. Patients generally present with complaints of secondary infertility. Although few cases of endometrial OM have been described in literature, to the best of our knowledge, only six cases of OM in cervix have been reported so far. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_574_18DOI Listing

First presentation of restrictive early onset eating disorders in Asian children.

Int J Eat Disord 2020 Apr 14. Epub 2020 Apr 14.

Adolescent Medicine Service, KKH, Singapore.

Objective: This study aims to describe the spectrum of children with restrictive early onset eating disorders (EOEDs), defined as below 13 years of age, presenting to a tertiary institution in Asia and comparing them with older adolescents with eating disorders.

Methods: This is a retrospective case review of Asian children who were treated in an eating disorder center. Baseline characteristics and inpatient management at first presentation of children younger than 13 years of age (EOED) were compared to those in older adolescents. Read More

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http://dx.doi.org/10.1002/eat.23274DOI Listing

Non-functioning pituitary adenomas and pregnancy: one-center experience and review of the literature.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

División Endocrinología, Hospital General de Agudos Dr. Carlos G. Durand, Buenos Aires, Argentina.

The usual clinical presentation of non-functioning pituitary adenoma (NFPA) consists of symptoms of mass effect and hypopituitarism. NFPA is a rare condition in young women and an uncommon complication during pregnancy. We present the outcome of three patients with NFPA during pregnancy. Read More

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http://dx.doi.org/10.20945/2359-3997000000232DOI Listing

Knowledge of PCOS in physicians-in-training: identifying gaps and educational opportunities.

Gynecol Endocrinol 2020 Apr 6:1-6. Epub 2020 Apr 6.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women. A recent study found that many obstetrics and gynecology (ObGyn) practicing physicians are unaware of the Rotterdam criteria recommended for diagnosis. Our objective was to identify gaps in trainee knowledge of PCOS diagnostic criteria and management. Read More

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http://dx.doi.org/10.1080/09513590.2020.1746761DOI Listing

Gonadotropin-Resistant Ovary Syndrome Presented with Secondary Amenorrhea and Infertility: A Case Report.

Iran J Med Sci 2020 Mar;45(2):140-142

Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Resistant ovary syndrome (ROS) is a presentation of hypergonadotrophic hypogonadism condition with very low incidence. Infertility is one of the most common complaints of women with this syndrome. We herein present a case of a 27-year-old woman with all features of secondary amenorrhea and secondary sexual characteristics. Read More

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http://dx.doi.org/10.30476/ijms.2019.81965.DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071552PMC

First custom next-generation sequencing infertility panel in Latin America: design and first results.

JBRA Assist Reprod 2020 May 1;24(2):104-114. Epub 2020 May 1.

Novagen. Buenos Aires, Argentina.

Objective: To present the development of the first custom gene panel for the diagnosis of male and female infertility in Latin America.

Methods: We developed a next-generation sequencing (NGS) panel that assesses genes associated with infertility. The panel targeted exons and their flanking regions. Read More

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http://dx.doi.org/10.5935/1518-0557.20190065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169920PMC

[Acquired vaginal stenosis: about a case and literature review].

Pan Afr Med J 2019 4;34:175. Epub 2019 Dec 4.

Department of Obstetrics and Gynecology I, University Hospital Center Hassan II, Fez, Morocco.

Vaginal stenosis or gynatresia is a congenital disease and it is part of Mayer-Rokitansky-Kustner-Hauser syndrome. Acquired vaginal stenosis is a rare complication of vaginal delivery and may be caused by an infection, charlatans, birth injury or postpartum hypoestrogeny. We report a case of postpartum complete vaginal stenosis secondary to vaginal injuries as a result of medical negligence. Read More

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http://dx.doi.org/10.11604/pamj.2019.34.175.15036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046101PMC

Long-Term Follow-Up and Treatment of a Female With Complete Estrogen Insensitivity.

J Clin Endocrinol Metab 2020 May;105(5)

Medical College of Georgia at Augusta University, Section of Reproductive Endocrinology, Infertility, & Genetics, Augusta, Georgia.

Context: We previously reported the first female with a causative ESR1 gene variant, who exhibited absent puberty and high estrogens. At age 15 years, she presented with lower abdominal pain, absent breast development, primary amenorrhea, and multicystic ovaries. The natural history of complete estrogen insensitivity (CEI) in women is unknown. Read More

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http://dx.doi.org/10.1210/clinem/dgaa106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108680PMC

Live Birth in Woman With Premature Ovarian Insufficiency Receiving Ovarian Administration of Platelet-Rich Plasma (PRP) in Combination With Gonadotropin: A Case Report.

Front Endocrinol (Lausanne) 2020 19;11:50. Epub 2020 Feb 19.

Taiwan United Birth-Promoting Experts (TUBE) Fertility Clinic, Tainan, Taiwan.

The conception rates among women with premature ovarian insufficiency (POI) remain extremely low. To achieve a successful pregnancy, most of these women have to receive donor oocytes through IVF treatment. Ovarian administration of platelet-rich plasma (PRP) has been recently applied to enhance the ovulatory function in women with poor ovarian response. Read More

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http://dx.doi.org/10.3389/fendo.2020.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043014PMC
February 2020

Menses Requires Energy: A Review of How Disordered Eating, Excessive Exercise, and High Stress Lead to Menstrual Irregularities.

Authors:
Kimberly Huhmann

Clin Ther 2020 03 2;42(3):401-407. Epub 2020 Mar 2.

Tufts Medical Center, Boston, MA, United States. Electronic address:

Purpose: Functional hypothalamic amenorrhea secondary to low weight, excessive exercise, and/or high levels of stress is common among young women. Adolescence is a time in development that a positive energy balance is crucial for puberty, menarche, and regular menstruation. Disordered eating and eating disorders are the third most common chronic illness and tend to start during puberty. Read More

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http://dx.doi.org/10.1016/j.clinthera.2020.01.016DOI Listing

Clinical profile and early therapeutic response to cabergoline of patients with hyperprolactinemia in a Cameroonian population.

Pan Afr Med J 2020 2;35. Epub 2020 Jan 2.

National Obesity Centre, Diabetes and Metabolic Diseases Unit, Yaounde Central Hospital, Yaounde, Cameroon.

Hyperprolactinemia is responsible for 20 to 25% of consultations of secondary amenorrhea and 17% for female infertility. Dopamine agonists are the gold standard treatment of hyperprolactinemia. Although they are associated with various adverse effects, cabergoline is generally preferred due to better compliance, limited side effects and good therapeutic response. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.2.12883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026510PMC

[Premature ovarian insufficiency - patients are underdiagnosed and undertreated].

Lakartidningen 2020 Feb 25;117. Epub 2020 Feb 25.

Karolinska Institutet - Kvinnor och barns hälsa Stockholm, Sweden Karolinska Institute - Women's and Childrens Health Stockholm, Sweden.

Women presenting with amenorrhea and elevated serum levels of FSH before the age of 40 may suffer from premature ovarian insufficiency (POI). POI can be caused by ovarian damage through surgery, irradiation and chemotherapy. Autoimmune disease and genetic causes are also possible causes for development of POI. Read More

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February 2020

[Does rupture of membranes have an impact on the fetal heart rate during spontaneous labor?]

Gynecol Obstet Fertil Senol 2020 Feb 21. Epub 2020 Feb 21.

Hôpital Jeanne de Flandre, Département d'obstétrique, CHU Lille, 59000, Lille, France; Université de Lille, EA4489 - Environnement périnatal et croissance, 59000, Lille, France. Electronic address:

Objectives: Evaluate the influence of rupture of membranes (spontaneous or artificial) on fetal heart rate. Secondary objectives were to compare spontaneous and artificial ruptures and to investigate the risk factors associated with the occurrence of abnormalities of fetal heart rate (FHR).

Methods: This is a monocentric retrospective study (Lille, France) from January to March 2018. Read More

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http://dx.doi.org/10.1016/j.gofs.2020.02.008DOI Listing
February 2020

Multicentric adrenocorticotropic hormone -producing steroid cell tumor of the fallopian tube & broad ligament in a 15 year old girl.

Gynecol Endocrinol 2020 Feb 24:1-4. Epub 2020 Feb 24.

Surgical Oncology unit, Oncology center, Mansoura University, Mansoura, Egypt.

Steroid cell tumors occur usually in the ovaries with very few reported cases of extra-ovarian origin. Our patient was a fifteen year old female, complaining from secondary amenorrhea and voice deepening. Values of serum cortisol, DHEA, FSH & LH were normal. Read More

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http://dx.doi.org/10.1080/09513590.2020.1731451DOI Listing
February 2020

SECONDARY AMENORRHOEA AS PRIMARY PRESENTATION OF IDIOPATHIC INTRACRANIAL HYPERTENSION.

Endocr Pract 2020 Feb 11. Epub 2020 Feb 11.

From: Department of Endocrinology, Institute of Post Graduate Medical Education and Research, Kolkata, India-700020.

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http://dx.doi.org/10.4158/EP-2020-0003DOI Listing
February 2020

Where Have the Periods Gone? The Evaluation and Management of Functional Hypothalamic Amenorrhea

J Clin Res Pediatr Endocrinol 2020 Feb;12(Suppl 1):18-27

University of Ottawa, Children’s Hospital of Eastern Ontario, Division of Gynecology, Ottawa, Canada

Functional hypothalamic amenorrhea (FHA) is a common cause of amenorrhea in adolescent girls. It is often seen in the setting of stress, weight loss, or excessive exercise. FHA is a diagnosis of exclusion. Read More

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http://dx.doi.org/10.4274/jcrpe.galenos.2019.2019.S0178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053439PMC
February 2020

What are the Predictive Factors for Preeclampsia in Oocyte Recipients?

J Hum Reprod Sci 2019 Oct-Dec;12(4):327-333. Epub 2019 Dec 17.

Department of Gynecology and Obstetrics, Rennes University Hospital, 16 bd de Bulgarie, 35200 Rennes, Rennes, France.

Objectives: Oocyte donation pregnancies are more frequently complicated by preeclampsia (PE), which cause significant fetal-maternal morbidity and mortality. Our objective was to determine risk factors for PE in oocyte recipients (OR). Our secondary objective was to describe the course of pregnancy and the neonatal outcome in this group. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_43_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937771PMC
December 2019

Ovarian dysgerminoma with Müllerian anomaly: a case report.

Obstet Gynecol Sci 2020 Jan 12;63(1):98-101. Epub 2019 Dec 12.

Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Müllerian anomalies are rare deformities in women, and only a few cases concerning gynecologic malignancies arising in patients with congenital uterine malformations have been reported. Herein, we present the case of a 34-year-old woman with dysgerminoma with a Müllerian anomaly (uterus didelphys). She had secondary amenorrhea, and an ovarian mass and uterus didelphys were discovered during examination. Read More

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http://dx.doi.org/10.5468/ogs.2020.63.1.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962580PMC
January 2020

Turner Syndrome Systematic Review: Spontaneous Thelarche and Menarche Stratified by Karyotype.

Horm Res Paediatr 2019 9;92(3):143-149. Epub 2020 Jan 9.

Division of Endocrinology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.

Background: Girls with Turner syndrome (TS) have a high incidence of primary ovarian insufficiency. Recent data show rates of spontaneous thelarche (ST) of 38% and spontaneous menarche (SM) of 15-16%, with higher rates in those with mosaicism.

Summary: We systematically reviewed the literature for evidence regarding rates of ST and SM in TS and evaluated rates based on the type of chromosomal mosaicism. Read More

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http://dx.doi.org/10.1159/000502902DOI Listing

Prolonged Amenorrhea and Low Hip Bone Mineral Density in Women Living With HIV-A Controlled Cross-sectional Study.

J Acquir Immune Defic Syndr 2020 Apr;83(5):486-495

Division of Infectious Diseases, Department of Medicine, University of British Columbia (UBC), Vancouver, British Columbia, Canada.

Background: Women living with HIV (WLWH) have higher rates of prolonged secondary amenorrhea (no flow for ≥1 year) than HIV-negative women. Both having amenorrhea and being HIV positive are associated with lower areal bone mineral density (BMD). However, their combined BMD effects remain unclear. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002282DOI Listing

Laparoscopic Excision of the Retroperitoneal Mullerian Cyst in a Different Location.

J Pediatr Adolesc Gynecol 2020 Jun 23;33(3):318-320. Epub 2019 Dec 23.

Department of Pediatric Surgery, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey.

Background: Herein, we report laparoscopic excision of a retroperitoneal Mullerian cyst, which is uniquely located medial to the left adrenal gland, mimicking adrenal adenoma in an adolescent girl.

Case: A healthy 13-year-old adolescent girl presented with secondary amenorrhea. Ultrasound and magnetic resonance imaging showed a solid-cystic mass medial to the left adrenal gland. Read More

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http://dx.doi.org/10.1016/j.jpag.2019.12.009DOI Listing
June 2020
1.812 Impact Factor

Severe hyperandrogenism due to ovarian hyperthecosis in a young woman.

BMJ Case Rep 2019 Dec 17;12(12). Epub 2019 Dec 17.

Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Hyperandrogenism is a relatively common clinical problem. However, severe hyperandrogenism causing virilisation is rare. A 27-year-old woman presented with generalised hirsutism, clitoromegaly, breast atrophy and secondary amenorrhoea. Read More

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http://dx.doi.org/10.1136/bcr-2019-232783DOI Listing
December 2019

Prevalence of autoimmune disease in women with premature ovarian failure.

Eur J Contracept Reprod Health Care 2020 Feb 18;25(1):72-75. Epub 2019 Dec 18.

Centre for Women's Health, Tübingen University Hospital, Tübingen, Germany.

The aim of the study was to investigate the relationship between premature ovarian failure and autoimmune disease. This interdisciplinary prospective study included 52 consecutively recruited women with premature ovarian failure, aged 18-40 years. Diagnosis of premature ovarian failure was defined as amenorrhoea lasting more than 4 months and anti-Müllerian hormone levels below the age-appropriate range. Read More

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http://dx.doi.org/10.1080/13625187.2019.1702638DOI Listing
February 2020

Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study.

BMJ Open 2019 12 15;9(12):e033780. Epub 2019 Dec 15.

Department of Obstetrics and Gynaecology, University of Oulu and Oulu University Hospital, Medical Research Centre, PEDEGO Research Unit, Oulu, Finland

Objectives: Previous studies of women in their 20s and 30s have reported impaired autonomic function in women with polycystic ovary syndrome (PCOS). We aimed to study, for the first time, whether PCOS is associated with impaired cardiac autonomic function independent of metabolic and hormonal status in their late reproductive years.

Design: A prospective Northern Finland Birth Cohort 1966 (NFBC1966) study including 5889 women born in 1966 and followed through the age of 46. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924836PMC
December 2019

Molecular Cytogenetic Characterization of a Karyotype of a Female Patient with Secondary Amenorrhea with a Cell Line Showing 46,X,+mar.

J Assoc Genet Technol 2019 ;45(4):180-186

The International Circle of Genetic Studies Chapter Los Angeles, CA.

Objectives: Disorders of sex development (DSD) include a group of conditions in which genotypes do not correlate with the typical male and female phenotypes. Numerical and structural abnormalities involving both autosomes and sex chromosomes have been observed in DSD. Specifically, deletions, duplications, and translocations involving specific genes as well as point mutations and less common aberrations have been implicated in the pathogenesis of these conditions. Read More

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January 2019