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    Luteinizing hormone elevation in ovarian granulosa cell tumor: a case report and review of the literature.
    J Ovarian Res 2017 Apr 24;10(1):30. Epub 2017 Apr 24.
    Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, People's Republic of China.
    Background: Ovarian granulosa cell tumors (GCTs) are the most common type of potentially malignant ovarian sex cord-stromal tumor. GCTs often produce estrogen and/or progesterone; consequently, symptoms related to hyperestrogenism are common at diagnosis. Nonspecific symptoms or signs associated with this neoplasm include amenorrhea and changes in various sex hormone levels, which can be hard to diagnose or explain. Read More

    Late pubertal growth spurt in a girl with growth hormone deficiency: Is Kaufmann therapy effective in a girl with short stature who responds poorly to growth hormone therapy and estrogen-replacement therapy?
    J Obstet Gynaecol Res 2017 Apr 19. Epub 2017 Apr 19.
    Department of Obstetrics and Gynecology, Kansai Medical University Medical Center, Osaka, Japan.
    A Japanese senior high school girl aged 18 years and 5 months with growth hormone deficiency was referred for primary amenorrhea. Her height was 1.36 m, and her bodyweight was 23. Read More

    Cigarette Smoking During Pregnancy: Do Complete Abstinence and Low Level Cigarette Smoking Have Similar Impact on Birth Weight?
    Nicotine Tob Res 2017 May;19(5):518-524
    NIH, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD.
    Objectives: Despite awareness of negative health outcomes associated with smoking, pregnant smokers might reduce their tobacco consumption thinking that a low smoking rate reduces smoking-related negative birth outcomes. We aimed to assess in a clinical sample whether there is a smoking rate that would not impact on birth weight (BW).

    Methods: Pregnant smokers ≥18 years, gestational age of 9-20 weeks of amenorrhea, motivated to quit smoking, smoking ≥5 cigarettes/day (cpd) and their newborns (381 singleton, live births) were included in this secondary analysis of a French smoking cessation trial. Read More

    Whole-exome sequencing identifies a homozygous donor splice site mutation in STAG3 that causes primary ovarian insufficiency.
    Clin Genet 2017 Apr 10. Epub 2017 Apr 10.
    Institute of Reproduction and Stem Cell Engineering, Central South University, Changsha, Hunan, 410078, People's Republic of China.
    Primary ovarian insufficiency (POI) is the depletion or loss of normal ovarian function, which cause infertility in women before the age of 40 years. Two homozygous germline truncation mutations in STAG3 gene had been reported to causes POI in consanguineous families. Here, we aimed to identify the genetic cause of POI in two affected sisters manifested with primary amenorrhea and partial development of secondary sexual characters with normal range of height of a consanguineous Han Chinese family. Read More

    Discordant Genotypic Sex and Phenotype Variations in Two Spanish Siblings with 17α-Hydroxylase/17,20-Lyase Deficiency Carrying the Most Prevalent Mutated CYP17A1 Alleles of Brazilian Patients.
    Sex Dev 2017 Apr 4. Epub 2017 Apr 4.
    Paediatric Endocrinology Unit, Vall d'Hebron Research Institute and Hospital, CIBERER, Autonomous University, Barcelona, Spain.
    17α-hydroxylase/17,20-lyase deficiency is a rare form of congenital adrenal hyperplasia caused by mutations in CYP17A1. Two phenotypic female sisters, aged 17 and 15 years and with 46,XY and 46,XX karyotypes, respectively, presented with primary amenorrhea and absent secondary sexual characteristics. The elder sib also presented with high blood pressure. Read More

    Premature Ovarian Insufficiency: Phenotypic Characterization within Different Etiologies.
    J Clin Endocrinol Metab 2017 Mar 28. Epub 2017 Mar 28.
    Center for Reproductive Medicine, Shandong University. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, China. The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.
    Context: Premature ovarian insufficiency (POI) is highly heterogeneous, both in phenotype and etiology. They are not yet clearly stated and correlated.

    Objective: To characterize clinical presentations of a large, well-phenotyped cohort of women with POI, and correlate phenotypes with etiologies to draw a comprehensive clinical picture of POI. Read More

    Vanishing White Matter (VWM) Disease Presenting As Neuro-Ovarian Failure.
    J Coll Physicians Surg Pak 2017 Mar;27(3):S41-S42
    Department of Medicine, Warrington Hospital, UK.
    A 19-year girl was admitted with a one-month history of worsening spastic paraparesis, cerbellar ataxia, visual decline and worsening headaches on a background of walking difficulty, progressive quadriparesis and migraine since the age of 10 years. She had no sensory loss, and cranial nerves examination was notable for optic atrophy with crescent formation only. She had primary amenorrhea and underdeveloped secondary sexual characteristics. Read More

    The Treatment of Dysmenorrhea.
    Pediatr Clin North Am 2017 Apr;64(2):331-342
    Section of Adolescent Medicine, Department of Pediatrics, Yale University School of Medicine, PO Box 208064, 330 Cedar Street, New Haven, CT 06520, USA. Electronic address:
    Menstrual disorders and abnormal uterine bleeding are common concerns of young women. Complaints include menses that are: too painful (dysmenorrhea), absent or occur irregularly (amenorrhea or oligoamenorrhea), or prolonged and heavy (menorrhagia, or excessive uterine bleeding). In providing optimal reproductive care, the medical provider must be able to distinguish between normal developmental patterns or symptoms requiring education and reassurance from pathologic conditions requiring prompt assessment and treatment. Read More

    Ectopic Pelvic Fibroid in a Woman With Uterine Agenesis and Mayer-Rokitansky-Küster-Hauser Syndrome.
    Ultrasound Q 2017 Mar 3. Epub 2017 Mar 3.
    *Department of Radiology, Faculty of Health Sciences, College of Medicine, University of Manitoba; and †Ultrasound Department, Radiology and Diagnostic Imaging, St Boniface General Hospital, Winnipeg, Manitoba, Canada.
    Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare disorder characterized by aplasia or hypoplasia of the uterus and vagina due to arrest in the development of the müllerian ducts. Women with this syndrome have the normal 46 XX karyotype, normal female secondary sex characteristics, and primary amenorrhea. Only a few cases have been described in the literature where a fibroid develops from a rudimentary, nonfunctioning uterus in patients with MRKH syndrome. Read More

    Primary Ovarian Insufficiency: Current Concepts.
    South Med J 2017 Mar;110(3):147-153
    From the Department of Reproductive Biology, Department of Gynecology, Case Western Reserve University, Cleveland, Ohio, and Department of Obstetrics and Gynecology, Wake Forest University, Winston-Salem, North Carolina.
    A potential consequence of chemotherapy is the destruction of oocytes, resulting in primary ovarian insufficiency (POI) in young patients; this often results in secondary amenorrhea and necessitates hormone replacement therapy. Regardless of the etiology of POI, the chance of pregnancy is low in this patient population. Given the extent to which oocyte depletion or dysfunction is variable, there is the possibility of spontaneous ovulation on hormone replacement therapy and subsequent pregnancy, however. Read More

    17A-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS.
    Endocr Pract 2017 Feb 22. Epub 2017 Feb 22.
    From: 1Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China.
    Background: 17α-hydroxylase/17, 20-lyase deficiency (17OHD) is caused by mutations in CYP17A1 gene.

    Objective: To better understand 17OHD, a rare disease, we described the clinical features and analyzed the CYP17A1 gene in eight affected Chinese patients.

    Methods: Patients with complete (7/8) or partial (1/8) 17OHD were derived from six families. Read More

    A rare case of 46,XX gonadal dysgenesis and Mayer-Rokitansky-Kuster-Hauser syndrome.
    J Hum Reprod Sci 2016 Oct-Dec;9(4):263-266
    Department of Radiology, G.S.L. Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India.
    46,XX gonadal dysgenesis is a rare genetically heterogeneous disorder characterized by underdeveloped ovaries with consequent, impuberism, primary amenorrhea, and hypergonadotropic hypogonadism. Mullerian agenesis or Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and the upper part (2/3) of the vagina in a woman with normal development of secondary sexual characteristics and a normal 46,XX karyotype. The phenotypic manifestations of MRKH syndrome may sometimes overlap with various other syndromes and require accurate delineation. Read More

    Different dosages of mifepristone versus enantone to treat uterine fibroids: A multicenter randomized controlled trial.
    Medicine (Baltimore) 2017 Feb;96(7):e6124
    aDepartment of Obstetrics and Gynaecology, Peking University First Hospital bDepartment of Obstetrics and Gynaecology,Beijing Chaoyang Hospital cDepartment of Obstetrics and Gynaecology, Peking University Third Hospital dDepartment of Obstetrics and Gynaecology, China-Japan Friendship Hospital, Beijing eDepartment of Obstetrics and Gynaecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai fDepartment of Obstetrics and Gynaecology, The Second Hospital of Hebei Medical University, Hebei gDepartment of Obstetrics and Gynaecology, Qilu Hospital of Shandong University, Shandong hDepartment of Obstetrics and Gynaecology, Shandong Provincial Hospital, Shandong, China.
    Background: To evaluate the efficacy and safety of 10 mg and 25 mg mifepristone per day compared with 3.75 mg enantone in treating uterine fibroids.

    Methods: This is a Multicenter randomized controlled trial. Read More

    Rationale and design of ASTEROID 2, a randomized, placebo- and active comparator-controlled study to assess the efficacy and safety of vilaprisan in patients with uterine fibroids.
    Contemp Clin Trials 2017 Apr 6;55:56-62. Epub 2017 Feb 6.
    Department of Women's and Children's Health (KBH), K6, Karolinska Universitetssjukhuset Solna, H2:00, 17176 Stockholm, Sweden. Electronic address:
    Background: Uterine fibroids (UFs) may be treated with progesterone receptor modulators (PRMs), which have been shown to reduce heavy menstrual bleeding and the size of UFs. To date, one PRM (ulipristal acetate) has received regulatory approval for the treatment of UFs; therapy comprises intermittent treatment courses of up to 3months each, followed by a break to allow two menstruations to occur. We report the design of ASTEROID (Assess Safety and efficacy of vilaprisan in patients with uTERine fibrOIDs) 2, a phase 2 study examining the efficacy and safety of a novel PRM, vilaprisan, in women with UFs. Read More

    Cervicovaginal agenesis treated with modified Yang-Monti technique in two steps: Case report and literature review.
    Int J Surg Case Rep 2017 19;31:176-179. Epub 2017 Jan 19.
    Department of General Surgery, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Mexico. Electronic address:
    Introduction: Müllerian duct anomalies are rare with less than 200 cases published in the literature. Recently, the implementation of the Yang-Monti principle for the creation of the neovagina has been used in 10 previous published cases. Here, we report the first case of cervicovaginal agenesis treated with the modified Yang-Monti technique in two steps in México. Read More

    [Atypical and rare cardiac revelation about Sheehan's syndrome: A report of three cases].
    Ann Cardiol Angeiol (Paris) 2017 Jan 24. Epub 2017 Jan 24.
    Service d'endocrinologie, diabétologie, maladie métaboliques et nutrition, CHU Med VI, Marrakech 40000, Maroc.
    Sheehan syndrome is a potentially serious complication in the postpartum period corresponding to ischemic necrosis of the anterior pituitary related to postpartum haemorrhage. We report three original observations showing an unusual mode of revelation of this syndrome. The first observation is that of a 46-year-old patient admitted initially to resuscitation for a recovered cardiorespiratory arrest, severe hypoglycemia and profound hyponatremia. Read More

    BMP15 "knockout-like" effect in familial premature ovarian insufficiency with persistent ovarian reserve.
    Clin Genet 2017 Jan 17. Epub 2017 Jan 17.
    Faculté de Médecine Paris Sud, Université Paris Sud, Université Paris Saclay, Le Kremlin Bicêtre, France.
    Premature ovarian insufficiency (POI) affects 1% to 2% of women under 40 years. Bone morphogenetic protein 15 (BMP15) variants have been described in POI. We studied a family with 2 sisters compound heterozygous for deletions in the BMP15 gene on chromosome Xp11. Read More

    Neuroendocrine carcinoma of the ovotestis: A case report and review of literatures.
    Int J Reprod Biomed (Yazd) 2016 Dec;14(12):783-786
    Department of Obstetrics and Gynecology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
    Background: Neuroendocine carcinoma of the gynecologic tract is rare and poses a significant clinical challenge because of tumor heterogeneity and lack of standardized guidelines for treatment. Ovotestis refers to the histology of a gonad that contains both ovarian follicles and testicular tubular elements. Ovotesticular disorder of sexual development occurs in fewer than 10% of all disorders of sexual development. Read More

    Wide spectrum of NR5A1-related phenotypes in 46,XY and 46,XX individuals.
    Birth Defects Res C Embryo Today 2016 12;108(4):309-320
    Sorahia Domenice, Aline Zamboni Machado, Bruno Ferraz-de-Souza, Antonio Marcondes Lerario, Mirian Yumie Nishi, Nathalia Lisboa Gomes, Thatiana Evelin da Silva, Rosana Barbosa Silva, Luciana R. Montenegro, Amanda Narciso, Elaine Maria Frade Costa, and Berenice Bilharinho Mendonca are from the Laboratório de Hormônios e Genética Molecular (LIM/42), Unidade de Endocrinologia do Desenvolvimento, Disciplina de Endocrinologia e Metabologia do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil.
    Steroidogenic factor 1 (NR5A1, SF-1, Ad4BP) is a transcriptional regulator of genes involved in adrenal and gonadal development and function. Mutations in NR5A1 have been among the most frequently identified genetic causes of gonadal development disorders and are associated with a wide phenotypic spectrum. In 46,XY individuals, NR5A1-related phenotypes may range from disorders of sex development (DSD) to oligo/azoospermia, and in 46,XX individuals, from 46,XX ovotesticular and testicular DSD to primary ovarian insufficiency (POI). Read More

    Evaluation of a new, low-dose levonorgestrel intrauterine contraceptive system over 5 years of use.
    Eur J Obstet Gynecol Reprod Biol 2016 Nov 20;210:22-28. Epub 2016 Nov 20.
    Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, CA, USA.
    Objective: To evaluate the efficacy and safety of a new, low-dose levonorgestrel intrauterine contraceptive system (LNG-IUS 12) for up to 5 years of use.

    Study Design: In this Phase III study, 2885 nulliparous and parous women aged 18-35 years were randomized to LNG-IUS 8 or LNG-IUS 12 for 3 years. After 3 years, women using LNG-IUS 12 could continue for up to 2 additional years (5 years total). Read More

    [Coeliac disease as a possible cause of some gynecological and obstetric abnormalities].
    Ceska Gynekol 2016 ;81(6):470-476
    Objective: To bring a review of available literature sources on the prevalence of coeliac disease and its possible impact on gynecological and obstetric disorders.

    Design: Review article.

    Setting: Gynecology and Obstetrics Clinic, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia. Read More

    A single-arm phase III study exploring the efficacy and safety of LNG-IUS 8, a low-dose levonorgestrel intrauterine contraceptive system (total content 13.5 mg), in an Asia-Pacific population.
    Contraception 2017 Apr 29;95(4):371-377. Epub 2016 Nov 29.
    Bayer HealthCare Pharmaceuticals, Seoul, Republic of Korea. Electronic address:
    Objective: The objective was to evaluate the efficacy and safety of a low-dose levonorgestrel intrauterine system with total content 13.5 mg (average approximately 8 μg/24 h over the first year; LNG-IUS 8; Jaydess®) in an Asia-Pacific population.

    Study Design: An open-label, single-arm phase III study conducted at 25 centers in China, Australia and Korea assessed LNG-IUS 8 use over 3 years in nulliparous and parous women (N=1114) aged 18-40 years with regular menstrual cycles (21-35 days). Read More

    Pathogenic Features of Dysuria in Young Women with Secondary Amenorrhea Caused by Body Weight Loss.
    Bull Exp Biol Med 2016 Dec 2;162(2):191-194. Epub 2016 Dec 2.
    Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
    We examined 11 women aged 19-26 years (mean age 22.5±3.5 years) with secondary amenorrhea complaining frequent urination over 1. Read More

    Association of Thyroid Profile and Prolactin Level in Patient with Secondary Amenorrhea.
    Malays J Med Sci 2016 Sep 5;23(5):51-56. Epub 2016 Oct 5.
    Department of Biochemistry, Universal College of Medical Sciences, Ranigaon, Bhairahawa, Nepal.
    Background: Amenorrhea is the absence of menstrual periods. It has multiple social consequences as it may leads to infertility. This case control study was conducted for determining the association of thyroid hormones with hyperprolactinemia in patient with amenorrhea. Read More

    Premature Ovarian Failure: An Association with Autoimmune Diseases.
    J Clin Diagn Res 2016 Oct 1;10(10):QC10-QC12. Epub 2016 Oct 1.
    Professor, Department of Obstetrics and Gynecology, Maulana Azad Medical College , New Delhi, India .
    Introduction: Premature Ovarian Failure (POF) is the cessation of ovarian function before the age of 40 years. POF is reported to be associated with autoimmune diseases in 20-30% of cases.

    Aim: Patients presenting with idiopathic POF were screened for the presence of autoimmune disorders. Read More

    Pulsatile gonadotropin-releasing hormone therapy in persistent amenorrheic weight-recovered anorexia nervosa patients.
    Fertil Steril 2017 Feb 22;107(2):502-509. Epub 2016 Nov 22.
    Department of Endocrinology, Diabetes, Metabolism and Eating Disorders, University hospital of Saint-Etienne, Saint-Etienne, France; Eating Disorders, Addictions & Extreme Bodyweight Research Group EA 7423, Jean Monnet University, Saint-Etienne, France.
    Objective: To compare hormonal and clinical responses to GnRH pulsatile treatment in weight-recovered anorexia nervosa patients (Rec-AN) with persistent functional hypothalamic amenorrhea (HA) vs. in patients with secondary and primary HA.

    Design: Retrospective, observational, ambulatory study. Read More

    Genetics of primary ovarian insufficiency.
    Clin Genet 2017 Feb 12;91(2):183-198. Epub 2016 Dec 12.
    Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy.
    Primary ovarian insufficiency (POI) is characterized by a loss of ovarian function before the age of 40 and account for one major cause of female infertility. POI relevance is continuously growing because of the increasing number of women desiring conception beyond 30 years of age, when POI prevalence is >1%. POI is highly heterogeneous and can present with ovarian dysgenesis and primary amenorrhea, or with secondary amenorrhea, and it can be associated with other congenital or acquired abnormalities. Read More

    Primary amenorrhea after bone marrow transplantation and adjuvant chemotherapy misdiagnosed as disorder of sex development: A case report.
    Medicine (Baltimore) 2016 Nov;95(44):e5190
    Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
    Introduction: Disorders of sex development (DSD) is a congenital condition in which the development of chromosomal, gonadal or genital sex is atypical. Majority of patients present clinical characteristics of primary amenorrhea, absent secondary sex characters, and abnormal hormone level. A female appearance patient with primary amenorrhea and 46 XY karyotype seems to be solid evidences to diagnose Y-chromosome-related DSD diseases, while it is not necessarily the accurate diagnosis. Read More

    Rare Case of Leiomyoma and Adenomyosis in Mayer-Rokitansky-Kuster-Hauser Syndrome.
    Case Rep Obstet Gynecol 2016 23;2016:3725043. Epub 2016 Oct 23.
    Obstetrics & Gynaecology Department, School of Medical Science, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
    We report a case of adenomyosis which developed from a hypoplastic uterus and leiomyoma in a patient with MRKH syndrome. A 45-year-old Malay female with primary amenorrhoea and primary infertility presented with abdominal mass and abdominal pain. She is phenotypically female, has well developed secondary sexual characteristics, and has normal female external genitalia with shallow vagina dimple. Read More

    Surgical Therapy of 17α-hydroxylase Deficiency in 30 Patients.
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2016 Oct;38(5):559-562
    Department of Obstetrics and Gynecology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
    Objective To analyze the clinical features of 17α-hydroxylase deficiency and explore the appropriate timing and methods of surgical treatment. Methods We retrospectively analyzed the clinical data of patients with complete 17α-hydroxylase deficiency,containing Y chromosome material in their karyotype,adimitted to Peking Union Medical College Hospital from January 2004 to December 2014. Results Thirty patients with complete 17α-hydroxylase deficiency were included. Read More

    [Effectiveness of a Rapid Response Team (RRT) in a case of ruptured ectopic pregnancy].
    Rev Med Inst Mex Seguro Soc 2016 Nov-Dec;54(6):787-792
    Hospital General Regional 1 "Vicente Guerrero", Instituto Mexicano del Seguro Social, Acapulco, Guerrero, México.
    Background: An ectopic pregnancy happens when a fertilized egg attaches somewhere outside the endometrial surface. This sort of pregnancy has an estimated incidence of 1.6 to 2 each 100 births. Read More

    Inositol Treatment and ART Outcomes in Women with PCOS.
    Int J Endocrinol 2016 4;2016:1979654. Epub 2016 Oct 4.
    Division of Reproductive Endocrinology & Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
    Polycystic ovary syndrome (PCOS) affects 5-10% of women in reproductive age and is characterized by oligo/amenorrhea, androgen excess, insulin resistance, and typical polycystic ovarian morphology. It is the most common cause of infertility secondary to ovulatory dysfunction. The underlying etiology is still unknown but is believed to be multifactorial. Read More

    Association of baseline bleeding pattern on amenorrhea with levonorgestrel intrauterine system use.
    Contraception 2016 Nov 27;94(5):556-560. Epub 2016 Jun 27.
    Division of Clinical Research, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:
    Objective: This study aims to evaluate the effect of baseline bleeding patterns on rates of amenorrhea reported at 12 months in levonorgestrel (LNG) 52 mg intrauterine system (IUS) users. We also assessed the effect of baseline bleeding patterns at 3 and 6 months postinsertion.

    Study Design: In this secondary analysis of the Contraceptive CHOICE Project, we included participants who had an LNG-IUS inserted within 1 month of enrollment and continued use for 12 months. Read More

    Tectal glioma presenting with clinical triad of obesity, amenorrhea and central cord syndrome with radiological pentad of hydrocephalus, empty sella, suprapineal diverticula, Chiari and syrinx.
    Childs Nerv Syst 2017 Feb 18;33(2):385-387. Epub 2016 Oct 18.
    Department of Radiology, PGIMER, Chandigarh, India.
    Background: Tectal gliomas (TG) are slow-growing tumors and generally present with features of increased intracranial pressure.

    Case Description: We describe an unusual case of a young girl who presented with clinical triad of obesity, primary amenorrhea and central cord syndrome. The radiology unveiled a pentad of hydrocephalus, empty sella, suprapineal recess diverticulum, secondary Chiari malformation and cervical syringomyelia, masking a relatively obscure tectal plate glioma. Read More

    Characteristics related to early secondary amenorrhoea and pregnancy among women diagnosed with systemic lupus erythematosus: an analysis using the GOAL study.
    Lupus Sci Med 2016 22;3(1):e000139. Epub 2016 Sep 22.
    Department of Rheumatology , Emory University School of Medicine , Atlanta, Georgia , USA.
    Objective: Systemic lupus erythematosus (SLE) disproportionately affects women and often develops during their reproductive years. Research suggests that some women who receive cyclophosphamide as treatment for SLE experience earlier decline in menstrual function, but reproductive health among women with SLE who have not taken this drug is less well understood. This study aims to better understand the relation between SLE and reproduction by assessing early secondary amenorrhoea and pregnancy in women treated with and without cyclophosphamide from a population-based cohort with large numbers of African-Americans. Read More

    [Intensive training and menstrual disorders in young female: Impact on bone mass].
    Gynecol Obstet Fertil 2016 Nov 15;44(11):659-663. Epub 2016 Oct 15.
    Unité d'endocrinologie et gynécologie pédiatrique, département de pédiatrie, hôpital A.-de-Villeneuve, UMI, CHRU de Montpellier, 34295 Montpellier, France.
    Participation in recreational physical activity is widely acknowledged to provide significant health benefits. Conversely, intense training imposes several constraints, such as intermittent or chronic metabolic and psychogenic training stressors and maintenance of very low body fat to maximize performance. Adolescent and adult athletic women are therefore at risk of overtraining and/or poor dietary intake, which may have several consequences for endocrine function particularly on hypothalamic-pituitary-gonadal axis. Read More

    Temporarily Blocking the Uterine Artery to Dig Out a Diffused Adenomyosis Lesion Treated Laparoscopically.
    J Minim Invasive Gynecol 2017 Mar - Apr;24(3):349-352. Epub 2016 Oct 1.
    Department of Gynecology, Changzhou Maternal and Child Health Hospital Affiliated to Nangjing Medical University, Changzhou, China.
    Study Objective: To show the tips and tricks of a simpler technique for temporary blocking of the uterine artery in laparoscopic resection of a diffuse adenomyosis lesion to make the procedure more efficient and reproducible.

    Design: This study is designed to be a step-by-step explanation of the technique using videos and pictures (Canadian Task Force classification III).

    Setting: Changzhou Maternal and Child Health Hospital, Changzhou, China. Read More

    Premature Ovarian Insufficiency: New Perspectives on Genetic Cause and Phenotypic Spectrum.
    Endocr Rev 2016 Dec 3;37(6):609-635. Epub 2016 Oct 3.
    Murdoch Children's Research Institute (E.J.T., S.R.G., A.H.S.), Royal Children's Hospital, Melbourne, VIC 3052 Australia; Department of Paediatrics (E.J.T., S.R.G., A.H.S.), University of Melbourne, Melbourne, VIC 3010, Australia; Department of Paediatric and Adolescent Gynaecology (S.R.G.), Royal Children's Hospital, Melbourne, VIC 3052, Australia; Assistance Publique Hôpitaux de Paris, (A.B., P.T.), IE3M, Université Pierre et Marie Curie, Paris 6 University, Department of Endocrinology and Reproductive Medicine, Centre de Référence des Maladies Endocriniennes Rares de la Croissance et des Pathologies Gynécologiques Rares, Pitié-Salpêtrière Hospital, Université Pierre et Marie Curie, 75013 Paris, France; Institut National de la Santé et de la Recherche Médicale (A.B., P.T.), 75654 Paris, France.
    Premature ovarian insufficiency (POI) is one form of female infertility, defined by loss of ovarian activity before the age of 40 and characterized by amenorrhea (primary or secondary) with raised gonadotropins and low estradiol. POI affects up to one in 100 females, including one in 1000 before the age of 30. Substantial evidence suggests a genetic basis for POI; however, the majority of cases remain unexplained, indicating that genes likely to be associated with this condition are yet to be discovered. Read More

    Efficacy, Safety, and Acceptability of Low-Dose Mifepristone and Self-Administered Misoprostol for Ultra-Early Medical Abortion: A Randomized Controlled Trial.
    Reprod Sci 2017 May 27;24(5):731-737. Epub 2016 Sep 27.
    1 Key Laboratory for Reproduction and Genetics of Guangdong Higher-Education Institutes and Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital, Guangzhou Institute of Obstetrics and Gynecology, Guangzhou Medical University, Guangzhou, People's Republic of China.
    The aim of this study was to investigate the efficacy, safety, and acceptability of low-dose mifepristone combined with self-administered misoprostol for ultra-early medical abortion. A total of 744 women with ultra-early pregnancy (amenorrhea ≤35 days) who fulfilled the inclusion criteria were enrolled in the study. Equal numbers of participants were allocated randomly to the hospital administration and self-administration groups. Read More

    Efficacy and safety of endometrial ablation for treating abnormal uterine bleeding in pre- and postmenopausal women with liver cirrhosis.
    J Obstet Gynaecol Res 2016 Dec 20;42(12):1753-1760. Epub 2016 Sep 20.
    Center for Major Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China.
    Aim: Abnormal uterine bleeding (AUB) occurs in 10-30% of women of reproductive age and up to 61% of cirrhotic women. We evaluated the efficacy and safety of endometrial ablation (NovaSure therapy) for AUB in cirrhotic women.

    Methods: This prospective, two-arm, observational study enrolled patients for NovaSure treatment, and they were followed for 12 months. Read More

    Patients with secondary amenorrhea due to tuberculosis endometritis towards the induced anti-tuberculosis drug category 1.
    Pan Afr Med J 2016 7;24:121. Epub 2016 Jun 7.
    Obstetrics and Gynecology Department, Medical Faculty, University of Brawijaya, Malang, Indonesia; Saiful Anwar Public Hospital, Malang.
    Tuberculosis (TB) is a disease which can affect various organs, including human's genital organs such as the endometrium. Tuberculosis endometritis can cause clinical symptoms of secondary amenorrhea and infertility. Infertility in genital TB caused by the involvement of the endometrium. Read More

    [Acute generalized peritonitis due to uterine perforation following abortion: case study observation].
    Pan Afr Med J 2016 27;24:98. Epub 2016 May 27.
    Service de Chirurgie Générale, Hôpital Général de Grand-Yoff, Dakar, Sénégal.
    Unlabelled: Clandestine abortion is known to be a major contributor to maternal mortality. We report a case of a 25-year old patient in her 12th week of amenorrhea with peritonitis due to uterine perforation following abortion, admitted with abdomen and pelvis pain, vomiting and diarrhea. Clinical examination on admission showed asthenic peritonitis. Read More

    Mayer-Rokitansky-Küster-Hauser Syndrome with Alopecia: A Rare Case Report with Review of Literature.
    Int J Trichology 2016 Jul-Sep;8(3):141-3
    Department of Dermatology Venereology and Leprosy, Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra, India.
    A 17-year-old girl presented with alopecia involving lateral margins of the scalp with primary amenorrhea. There was no history of parental consanguinity, and no other siblings were having similar complaints. Her secondary sexual characters were well developed with hypoplastic vagina. Read More

    Hypopituitarism and goitre as endocrine manifestation of Langerhans cell histiocytosis (LCH). Case Report.
    Neuro Endocrinol Lett 2016 Jul;37(3):174-178
    Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Poland.
    Langerhans cell histiocytosis (LCH) in adults is a rare disorder of unknown etiology characterized by monoclonal proliferation of Langerhans cells. It belongs to dendritic cell disorders and occurs in 1-2 adults per million. The most common endocrine manifestation of classical LCH is associated with the posterior pituitary, with clinical symptoms of diabetes insipidus. Read More

    Clinical Features of 32 Patients with XO/XY Gonadal Dysgenesis.
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2016 Aug;38(4):411-4
    Department of Obstetrics and Gynecology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
    Objective To summarize the clinical features of XO/XY gonadal dysgenesis. Method We retrospectively analyzed the clinical data of patients with XO/XY gonadal dysgenesis admitted to Peking Union Medical College Hospital from January 2008 to May 2015. Results Totally 32 patients with XO/XY gonadal dysgenesis were included. Read More

    Assessment of the menstrual cycle, eating disorders and self-esteem of Polish adolescents.
    J Psychosom Obstet Gynaecol 2017 Mar 1;38(1):30-36. Epub 2016 Sep 1.
    a School of Health Sciences in Katowice, Medical University of Silesia , Katowice , Poland.
    Introduction: Eating disorders are an important factor in menstrual cycle disorders in girls. Moreover, low self-esteem among adolescent girls may be a risk factor for eating disorders. The aim of the study was to assess the menstrual cycle, eating habits and self-esteem of Polish adolescents. Read More

    Systemic sarcoidosis with hypercalcaemia, hypothalamic-pituitary dysfunction and thyroid involvement.
    BMJ Case Rep 2016 Aug 5;2016. Epub 2016 Aug 5.
    Department of Endocrinology and Metabolism, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA.
    Sarcoidosis is a multisystem granulomatous disorder. The lungs are the principal organs affected, however, extrapulmonary involvement including disorders of the pituitary and thyroid glands has been reported but presentation with multiple endocrine manifestations is rare. We report the case of a 36-year-old African-American woman who presented with hypercalcaemia, abnormal thyroid function studies and secondary amenorrhoea. Read More

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