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    Secondary amenorrhea: Diagnostic approach and treatment considerations.
    Nurse Pract 2017 Sep;42(9):34-41
    Katherine Pereira is an associate professor at Duke University School of Nursing, Durham, N.C., and a family NP at Duke University Medical Center, Division of Endocrinology, Metabolism and Nutrition, Durham, N.C. Ann J. Brown is an associate professor of medicine and vice dean for faculty at Duke University School of Medicine, Durham, N.C.
    Disruptions in the menstrual cycle are a common complaint in primary care and women's health. Irregular or absent menstrual periods should trigger an evaluation to identify the root cause. This article discusses secondary amenorrhea and provides a systematic approach to its diagnostic evaluation, with referral considerations. Read More

    An unusual cause of isolated secondary ovarian failure due to cerebral toxoplasmosis in an African woman with AIDS.
    BMJ Case Rep 2017 Aug 7;2017. Epub 2017 Aug 7.
    ABM University Health Board, Singleton Hospital, GUM/HIV, Swansea, UK.
    Primary ovarian failure is common. However, isolated secondary ovarian failure due to gonadotrophin deficiency is rare. A few cases of isolated gonadotrophin deficiency, due to congenital cerebral toxoplasmosis, have been described in children. Read More

    Enhanced Expression of FRA16B using AT-Rich DNA Binding Chemicals in a Woman with Secondary Amenorrhoea.
    J Clin Diagn Res 2017 Jun 1;11(6):QD01-QD03. Epub 2017 Jun 1.
    Professor and Head (Retd.), Department of of Genetics, Dr. ALM Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, Tamil Nadu, India.
    Fragile sites represent regions of chromatin that fail to compact during mitosis. Based on the prevalence and pattern of inheritance they are classified as rare fragile sites or common fragile sites. Rare fragile sites either occur spontaneously or can be induced by certain AT-specific binding chemicals namely distamycin, Hoechst 33258, Berenil and others. Read More

    Diminished ovarian reserve in women with transfusion-dependent beta-thalassemia major: Is iron gonadotoxic?
    Eur J Obstet Gynecol Reprod Biol 2017 Jul 5;216:69-73. Epub 2017 Jul 5.
    Health Science University, Antalya Training and Research Hospital, Department of Hematology, Turkey.
    Objective: Iron accumulation in the endocrine glands has been implicated in the aetiopathogenesis of decreased reproductive capacity in patients with beta-thalassemia major (β-TM). The aim of the current study was to investigate the serum concentration of anti-Müllerian hormone (AMH), a marker of ovarian reserve, in women with transfusion-dependent β-TM.

    Study Design: In this case-control study, we recruited 43 women with transfusion-dependent TM and 44 age-matched healthy controls. Read More

    Reduced Neuromuscular Performance in Amenorrheic Elite Endurance Athletes.
    Med Sci Sports Exerc 2017 Jul 19. Epub 2017 Jul 19.
    1Department of Health Sciences, Lund University, Lund, Sweden; 2Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark; 3Endocrinological and Reproductive Unit, Department of Obstetrics and Gynecology, Herlev Hospital, Denmark; 4Department of Endocrinology, Herlev Hospital, Denmark; 5Faculty of Health and Medical Sciences, University of Copenhagen, Herlev, Denmark.
    Introduction: Secondary functional hypothalamic amenorrhea (SFHA) is common among female athletes, especially in weight-sensitive sports. The aim of this study was to investigate the link between SFHA and neuromuscular performance in elite endurance athletes.

    Methods: Sixteen eumenorrheic (EUM) and 14 SFHA athletes from national teams and competitive clubs participated. Read More

    Menopause and Chronic Kidney Disease.
    Semin Nephrol 2017 Jul;37(4):404-411
    Department of Medicine, University of Calgary, Calgary, Canada; Alberta Kidney Disease Network, Alberta, Canada; Libin Cardiovascular Institute of Alberta, Calgary, Canada. Electronic address:
    Premature menopause defined as secondary amenorrhea is common in women with kidney disease. Moreover, the aging population has resulted in increasing numbers of postmenopausal women with kidney disease. Though the pathophysiology is poorly understood, kidney transplantation and more frequent hemodialysis can restore menses and fertility, highlighting the challenges of diagnosing and managing the menopausal transition in the female population with kidney disease. Read More

    Late Diagnosis of 5-α-Reductase Type 2 Deficiency in an Adolescent Girl with Primary Amenorrhoea.
    Sultan Qaboos Univ Med J 2017 May 20;17(2):e218-e220. Epub 2017 Jun 20.
    Department of Family & Community Medicine, College of Medicine, Najran University, Najran, Saudi Arabia.
    Deficiency of the 5-α-reductase enzyme has been found to affect male sexual development. We report an 18-year-old patient who was referred to an endocrinology clinic in Jizan, Saudi Arabia, in April 2014 with primary amenorrhoea, virilisation and a lack of secondary sex characteristics. As female external genitalia were present at birth, she had been raised as a female. Read More

    Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial.
    Phytother Res 2017 Jul 7. Epub 2017 Jul 7.
    National Institute of Complementary Medicine, Western Sydney University, Building 5, Campbelltown Campus, Locked Bag 1797, Penrith, NSW, 2751, Australia.
    Polycystic ovary syndrome (PCOS) is a common, complex reproductive endocrinopathy characterized by menstrual irregularities, hyperandrogenism and polycystic ovaries. Lifestyle modification is a first-line intervention; however, there are barriers to success for this form of self-care, and women often seek adjunct therapies including herbal medicines. This pragmatic, randomized controlled trial, delivered in communities of Australia in overweight women with PCOS, compared the effectiveness and safety of a lifestyle intervention plus herbal medicine against lifestyle alone. Read More

    Successful pregnancy with donor eggs in-vitro fertilization after premature ovarian insufficiency in a tertiary hospital in a low-income setting: a case report.
    Fertil Res Pract 2016 21;2:12. Epub 2016 Nov 21.
    Clinique de l'Aeroport, Douala, Cameroon.
    Background: Premature Ovarian Insufficiency (POI) is classically defined as 4-6 months of cessation of menses (amenorrhea) in women under 40, associated with menopausal level of serum gonadotropins FSH > 40 IU/L and hypo-estrogenism and is also referred to as hypergonadotropic hypogonadism. This disorder can manifest as primary amenorrhea without the onset of menses (menarche), or as secondary amenorrhea after menarche and pubertal development. The diagnosis of this condition in Cameroon is sometimes difficult because of the high cost of hormonal assays and the few laboratories offering these services. Read More

    Premature ovarian insufficiency in general practice: Meeting the needs of women.
    Aust Fam Physician 2017 Jun;46(6):360-366
    Background: Premature ovarian insufficiency (POI), defined as amenorrhoea due to the loss of ovarian function before 40 years of age, can occur spontaneously or be secondary to medical therapies. POI is associated with cardiovascular morbidity, osteoporosis and premature mortality. Women with POI present in primary care with menstrual disturbance, menopausal symptoms, infertility and, often, significant psychosocial issues. Read More

    Emmenagogue properties of Milicia excelsa (Welw.) C.C. Berg (Moraceae) based, at least in part, on its ability to correlate the activity of the hypothalamic-pituitary axis to that of the ovaries.
    J Ethnopharmacol 2017 Jul 6;206:283-289. Epub 2017 Jun 6.
    Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.
    Ethnopharmacological Relevance: Milicia excelsa (Welw.) C.C. Read More

    Vitamin D levels strongly influence bone mineral density and bone turnover markers during weight gain in female patients with anorexia nervosa.
    Int J Eat Disord 2017 Jun 7. Epub 2017 Jun 7.
    Department of Medicine, Rheumatology Unit, University of Verona, Piazzale L.A. Scuro 10, Verona, 37026, Italy.
    Objective: The aim of the study was to investigate a potential role for vitamin D status on bone mineral density (BMD) during weight gain in patients with anorexia nervosa (AN).

    Method: Spine and hip BMD assessed by dual-energy X-ray absorptiometry (DXA), serum vitamin D (25-OH-D), N-propeptide of type I collagen (P1NP), C-terminal telopeptide of type I collagen (CTX), and intact parathyroid hormone (PTH) were measured before and after a 20-week intensive weight-restoration program in ninety-one female patients with AN and secondary amenorrhoea.

    Results: Ninety-one consecutive female patients (age 13-45 years; weight 39. Read More

    The role of total body fat mass and trunk fat mass, combined with other endocrine factors, in menstrual recovery and psychopathology of adolescents with Anorexia Nervosa.
    Gynecol Endocrinol 2017 May 31:1-6. Epub 2017 May 31.
    a Division of Pediatric-Adolescent Gynecology & Reconstructive Surgery, 2nd Department of Obstetrics & Gynecology , National and Kapodistrian University of Athens, Medical School, "Aretaieion" Hospital , Athens , Greece.
    Objective: To determine the threshold of total body and trunk fat mass required for menstrual recovery and to assess the impact of body composition in psychopathology of adolescents with Anorexia Nervosa (AN).

    Methods: Prospective study of 60 adolescents presented with secondary amenorrhea and diagnosed with AN. Anthropometrics, body composition by dual-energy X-ray absorptiometry, hormonal studies and responses to mental health screens (EAT-26), were obtained at the beginning and at complete weight restoration, in all adolescents, independently of menstrual recovery (Group A) or not (Group B). Read More

    Pharmacological treatment options for low Bone Mineral Density and secondary osteoporosis in Anorexia Nervosa: A systematic review of the literature.
    J Psychosom Res 2017 Jul 12;98:87-97. Epub 2017 May 12.
    Institute of Child Health, University College London, Gower Street, London WC1E 6BT, UK; Dept. of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.
    Objective: Although there are several evidence-based treatments available to increase Bone Mineral Density (BMD) and reduce fracture risk in aging men and women, there are still uncertainties regarding which treatments are efficacious in reducing lifetime fracture risk in women with Anorexia Nervosa (AN).

    Methods: Medline, PsychInfo, Embase and the Cochrane Database were searched for English Language Studies. Inclusion criteria were studies of females of any age with AN who received pharmacological treatment with the primary aim to increase BMD or reduce fracture risk. Read More

    Evaluation of the quality of life of pregnant women from 2005 to 2015.
    Eur J Obstet Gynecol Reprod Biol 2017 Jul 10;214:115-130. Epub 2017 May 10.
    University Claude Bernard Lyon I, Laboratory Health - Individual - Society, Team P2S (EA 4129), 7-11 rue Guillaume Paradin, 69372 Lyon Cedex 08, France.
    Over the past two decades, quality of life has become an essential preoccupation in the care of patients. Many measuring instruments are available to assess physical, psychological and social quality of life. These tools allow healthcare professionals to determine the best quality of their patients. Read More

    Life After Treatment: Quality-of-Life Concerns in Patients Treated for Cancer.
    J Natl Compr Canc Netw 2017 May;15(5S):744-747
    Presented by Mindy E. Goldman, MD, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, and Breast Oncology Program, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.
    Traditionally, the physical, psychological, and psychosocial long-term needs of cancer survivors have received little attention compared with screening for cancer recurrence and secondary cancers. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Survivorship offer recommendations for various survivorship concerns, and those for improving menopausal symptoms were presented at the NCCN 22nd Annual Conference. Key considerations in managing menopausal symptoms in cancer survivors were reviewed, with chemotherapy-induced amenorrhea, fertility concerns, and both hormonal and nonhormonal therapeutic options featured. Read More

    Premature Ovarian Insufficiency: An Adolescent Series.
    J Pediatr Adolesc Gynecol 2017 May 11. Epub 2017 May 11.
    1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece. Electronic address:
    Study Objective: To study the presentation and causes of premature ovarian insufficiency (POI) in adolescents.

    Design: Retrospective notes review.

    Setting: Tertiary referral outpatient clinic for pediatric and adolescent gynecology. Read More

    Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B as a Cause of Secondary Amenorrhea in an Adolescent with Germ Line DICER1 Mutation.
    J Pediatr Adolesc Gynecol 2017 May 11. Epub 2017 May 11.
    San Antonio Uniformed Services Health Education Consortium, JBSA, Fort Sam Houston, San Antonio, Texas. Electronic address:
    Background: Ovarian tumors, although uncommon in children, can retain endocrine function that disrupts normal feedback mechanisms leading to amenorrhea. Inheritance of germline DICER1 mutations can lead to increased risk for development of ovarian Sertoli-Leydig cell tumors (SLCTs).

    Case: We report, to our knowledge, the first case of secondary amenorrhea due to elevated inhibin B levels in a female adolescent with an ovarian SLCT. Read More

    Serum kisspeptin concentrations are negatively correlated with body mass index in adolescents with anorexia nervosa and amenorrhea.
    Hormones (Athens) 2017 Jan;16(1):33-41
    Faculty of Pharmacy, Department of Pharmaceutical Technology, Laboratory of Biopharmaceutics and Pharmacokinetics, National and Kapodistrian University of Athens, Athens, Greece.
    Objective: To measure, for the first time, serum kisspeptin concentrations in adolescent females with anorexia nervosa (AN) and associated amenorrhea, and investigate potential correlations of kisspeptin with anthropometric, bone and hormonal data.

    Design: Setting: University Adolescent Medicine Center.

    Participants: Females aged 12-20 years with typical or atypical AN (based on DSM-5 diagnostic criteria) and controls. Read More

    Premature Ovarian Failure - An Unusual Manifestation of Systemic Sclerosis.
    J Hum Reprod Sci 2017 Jan-Mar;10(1):58-60
    Department of Medicine, Lady Hardinge Medical College and SSK Hospital, New Delhi, Delhi, India.
    A 31-year-old woman presented with secondary amenorrhoea and inability to conceive, which was of 3 years duration. She had Raynaud's phenomenon for 16 years, primary hypothyroidism for 5 years, digital ulcers for 4 years and skin tightening for 2 years. She had an expressionless face, with loss of wrinkles and restriction of the mouth opening along with flexion contractures of the hands and the terminal digit resorptions. Read More

    Using kisspeptin to assess GnRH function in an unusual case of primary amenorrhoea.
    Endocrinol Diabetes Metab Case Rep 2017 27;2017. Epub 2017 Mar 27.
    Department of Endocrinology & Metabolism, Imperial College LondonUK.
    Summary: Primary amenorrhoea is defined as the failure to commence menstruation by the age of 15 years, in the presence of normal secondary sexual development. The potential causes of primary amenorrhoea extend from structural to chromosomal abnormalities. Polycystic ovarian syndrome (PCOS) is a common cause of secondary amenorrhoea but an uncommon cause of primary amenorrhoea. Read More

    Primary ovarian insufficiency with t(5;13): a case report and literature review on disrupted genes.
    Climacteric 2017 Apr 28:1-5. Epub 2017 Apr 28.
    b Reproductive Biotechnology Research Center , Avicenna Research Institute, ACECR , Tehran , Iran.
    Objectives: To report a woman with primary ovarian insufficiency (POI) with reciprocal translocation between chromosomes 5 and 13.

    Methods: Chromosomal analysis (G-banding) of a 39-year-old woman with elevated gonadotropin levels and secondary amenorrhea and review of the literature with a special focus on disrupted genes at the reported breakpoints.

    Results: A reciprocal translocation between the long arms of chromosomes 5 and 13 was identified in the patient (46,XX,t(5;13)(q13;q14)). Read More

    Luteinizing hormone elevation in ovarian granulosa cell tumor: a case report and review of the literature.
    J Ovarian Res 2017 Apr 24;10(1):30. Epub 2017 Apr 24.
    Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, People's Republic of China.
    Background: Ovarian granulosa cell tumors (GCTs) are the most common type of potentially malignant ovarian sex cord-stromal tumor. GCTs often produce estrogen and/or progesterone; consequently, symptoms related to hyperestrogenism are common at diagnosis. Nonspecific symptoms or signs associated with this neoplasm include amenorrhea and changes in various sex hormone levels, which can be hard to diagnose or explain. Read More

    Late pubertal growth spurt in a girl with growth hormone deficiency: Is Kaufmann therapy effective in a girl with short stature who responds poorly to growth hormone therapy and estrogen-replacement therapy?
    J Obstet Gynaecol Res 2017 May 19;43(5):951-956. Epub 2017 Apr 19.
    Department of Obstetrics and Gynecology, Kansai Medical University Medical Center, Osaka, Japan.
    A Japanese senior high school girl aged 18 years and 5 months with growth hormone deficiency was referred for primary amenorrhea. Her height was 1.36 m, and her bodyweight was 23. Read More

    Cigarette Smoking During Pregnancy: Do Complete Abstinence and Low Level Cigarette Smoking Have Similar Impact on Birth Weight?
    Nicotine Tob Res 2017 May;19(5):518-524
    NIH, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD.
    Objectives: Despite awareness of negative health outcomes associated with smoking, pregnant smokers might reduce their tobacco consumption thinking that a low smoking rate reduces smoking-related negative birth outcomes. We aimed to assess in a clinical sample whether there is a smoking rate that would not impact on birth weight (BW).

    Methods: Pregnant smokers ≥18 years, gestational age of 9-20 weeks of amenorrhea, motivated to quit smoking, smoking ≥5 cigarettes/day (cpd) and their newborns (381 singleton, live births) were included in this secondary analysis of a French smoking cessation trial. Read More

    Whole-exome sequencing identifies a homozygous donor splice-site mutation in STAG3 that causes primary ovarian insufficiency.
    Clin Genet 2017 Apr 10. Epub 2017 Apr 10.
    Institute of Reproduction and Stem Cell Engineering, Central South University, Changsha, People's Republic of China.
    Primary ovarian insufficiency (POI) is the depletion or loss of normal ovarian function, which cause infertility in women before the age of 40 years. Two homozygous germline truncation mutations in STAG3 gene had been reported to causes POI in consanguineous families. Here, we aimed to identify the genetic cause of POI in 2 affected sisters manifested with primary amenorrhea and partial development of secondary sexual characters with normal range of height of a consanguineous Han Chinese family. Read More

    Discordant Genotypic Sex and Phenotype Variations in Two Spanish Siblings with 17α-Hydroxylase/17,20-Lyase Deficiency Carrying the Most Prevalent Mutated CYP17A1 Alleles of Brazilian Patients.
    Sex Dev 2017 4;11(2):70-77. Epub 2017 Apr 4.
    Paediatric Endocrinology Unit, Vall d'Hebron Research Institute and Hospital, CIBERER, Autonomous University, Barcelona, Spain.
    17α-hydroxylase/17,20-lyase deficiency is a rare form of congenital adrenal hyperplasia caused by mutations in CYP17A1. Two phenotypic female sisters, aged 17 and 15 years and with 46,XY and 46,XX karyotypes, respectively, presented with primary amenorrhea and absent secondary sexual characteristics. The elder sib also presented with high blood pressure. Read More

    Premature Ovarian Insufficiency: Phenotypic Characterization within Different Etiologies.
    J Clin Endocrinol Metab 2017 Mar 28. Epub 2017 Mar 28.
    Center for Reproductive Medicine, Shandong University. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, China. The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.
    Context: Premature ovarian insufficiency (POI) is highly heterogeneous, both in phenotype and etiology. They are not yet clearly stated and correlated.

    Objective: To characterize clinical presentations of a large, well-phenotyped cohort of women with POI, and correlate phenotypes with etiologies to draw a comprehensive clinical picture of POI. Read More

    Vanishing White Matter (VWM) Disease Presenting As Neuro-Ovarian Failure.
    J Coll Physicians Surg Pak 2017 Mar;27(3):S41-S42
    Department of Medicine, Warrington Hospital, UK.
    A 19-year girl was admitted with a one-month history of worsening spastic paraparesis, cerbellar ataxia, visual decline and worsening headaches on a background of walking difficulty, progressive quadriparesis and migraine since the age of 10 years. She had no sensory loss, and cranial nerves examination was notable for optic atrophy with crescent formation only. She had primary amenorrhea and underdeveloped secondary sexual characteristics. Read More

    The Treatment of Dysmenorrhea.
    Pediatr Clin North Am 2017 Apr;64(2):331-342
    Section of Adolescent Medicine, Department of Pediatrics, Yale University School of Medicine, PO Box 208064, 330 Cedar Street, New Haven, CT 06520, USA. Electronic address:
    Menstrual disorders and abnormal uterine bleeding are common concerns of young women. Complaints include menses that are: too painful (dysmenorrhea), absent or occur irregularly (amenorrhea or oligoamenorrhea), or prolonged and heavy (menorrhagia, or excessive uterine bleeding). In providing optimal reproductive care, the medical provider must be able to distinguish between normal developmental patterns or symptoms requiring education and reassurance from pathologic conditions requiring prompt assessment and treatment. Read More

    Ectopic Pelvic Fibroid in a Woman With Uterine Agenesis and Mayer-Rokitansky-Küster-Hauser Syndrome.
    Ultrasound Q 2017 Sep;33(3):237-241
    *Department of Radiology, Faculty of Health Sciences, College of Medicine, University of Manitoba; and †Ultrasound Department, Radiology and Diagnostic Imaging, St Boniface General Hospital, Winnipeg, Manitoba, Canada.
    Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare disorder characterized by aplasia or hypoplasia of the uterus and vagina due to arrest in the development of the müllerian ducts. Women with this syndrome have the normal 46 XX karyotype, normal female secondary sex characteristics, and primary amenorrhea. Only a few cases have been described in the literature where a fibroid develops from a rudimentary, nonfunctioning uterus in patients with MRKH syndrome. Read More

    Primary Ovarian Insufficiency: Current Concepts.
    South Med J 2017 Mar;110(3):147-153
    From the Department of Reproductive Biology, Department of Gynecology, Case Western Reserve University, Cleveland, Ohio, and Department of Obstetrics and Gynecology, Wake Forest University, Winston-Salem, North Carolina.
    A potential consequence of chemotherapy is the destruction of oocytes, resulting in primary ovarian insufficiency (POI) in young patients; this often results in secondary amenorrhea and necessitates hormone replacement therapy. Regardless of the etiology of POI, the chance of pregnancy is low in this patient population. Given the extent to which oocyte depletion or dysfunction is variable, there is the possibility of spontaneous ovulation on hormone replacement therapy and subsequent pregnancy, however. Read More

    17α-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS.
    Endocr Pract 2017 May 22;23(5):576-582. Epub 2017 Feb 22.
    Objective: 17α-hydroxylase/17, 20-lyase deficiency (17OHD) is caused by mutations in the cytochrome P450 17A1 (CYP17A1) gene. To better understand 17OHD, a rare disease, we described the clinical features and performed CYP17A1 gene analysis in 8 affected Chinese patients.

    Methods: Patients with complete (7/8) or partial (1/8) 17OHD were derived from 6 families. Read More

    A rare case of 46,XX gonadal dysgenesis and Mayer-Rokitansky-Kuster-Hauser syndrome.
    J Hum Reprod Sci 2016 Oct-Dec;9(4):263-266
    Department of Radiology, G.S.L. Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India.
    46,XX gonadal dysgenesis is a rare genetically heterogeneous disorder characterized by underdeveloped ovaries with consequent, impuberism, primary amenorrhea, and hypergonadotropic hypogonadism. Mullerian agenesis or Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and the upper part (2/3) of the vagina in a woman with normal development of secondary sexual characteristics and a normal 46,XX karyotype. The phenotypic manifestations of MRKH syndrome may sometimes overlap with various other syndromes and require accurate delineation. Read More

    Different dosages of mifepristone versus enantone to treat uterine fibroids: A multicenter randomized controlled trial.
    Medicine (Baltimore) 2017 Feb;96(7):e6124
    aDepartment of Obstetrics and Gynaecology, Peking University First Hospital bDepartment of Obstetrics and Gynaecology,Beijing Chaoyang Hospital cDepartment of Obstetrics and Gynaecology, Peking University Third Hospital dDepartment of Obstetrics and Gynaecology, China-Japan Friendship Hospital, Beijing eDepartment of Obstetrics and Gynaecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai fDepartment of Obstetrics and Gynaecology, The Second Hospital of Hebei Medical University, Hebei gDepartment of Obstetrics and Gynaecology, Qilu Hospital of Shandong University, Shandong hDepartment of Obstetrics and Gynaecology, Shandong Provincial Hospital, Shandong, China.
    Background: To evaluate the efficacy and safety of 10 mg and 25 mg mifepristone per day compared with 3.75 mg enantone in treating uterine fibroids.

    Methods: This is a Multicenter randomized controlled trial. Read More

    Rationale and design of ASTEROID 2, a randomized, placebo- and active comparator-controlled study to assess the efficacy and safety of vilaprisan in patients with uterine fibroids.
    Contemp Clin Trials 2017 Apr 6;55:56-62. Epub 2017 Feb 6.
    Department of Women's and Children's Health (KBH), K6, Karolinska Universitetssjukhuset Solna, H2:00, 17176 Stockholm, Sweden. Electronic address:
    Background: Uterine fibroids (UFs) may be treated with progesterone receptor modulators (PRMs), which have been shown to reduce heavy menstrual bleeding and the size of UFs. To date, one PRM (ulipristal acetate) has received regulatory approval for the treatment of UFs; therapy comprises intermittent treatment courses of up to 3months each, followed by a break to allow two menstruations to occur. We report the design of ASTEROID (Assess Safety and efficacy of vilaprisan in patients with uTERine fibrOIDs) 2, a phase 2 study examining the efficacy and safety of a novel PRM, vilaprisan, in women with UFs. Read More

    Cervicovaginal agenesis treated with modified Yang-Monti technique in two steps: Case report and literature review.
    Int J Surg Case Rep 2017 19;31:176-179. Epub 2017 Jan 19.
    Department of General Surgery, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Mexico. Electronic address:
    Introduction: Müllerian duct anomalies are rare with less than 200 cases published in the literature. Recently, the implementation of the Yang-Monti principle for the creation of the neovagina has been used in 10 previous published cases. Here, we report the first case of cervicovaginal agenesis treated with the modified Yang-Monti technique in two steps in México. Read More

    [Atypical and rare cardiac revelation about Sheehan's syndrome: A report of three cases].
    Ann Cardiol Angeiol (Paris) 2017 Jan 24. Epub 2017 Jan 24.
    Service d'endocrinologie, diabétologie, maladie métaboliques et nutrition, CHU Med VI, Marrakech 40000, Maroc.
    Sheehan syndrome is a potentially serious complication in the postpartum period corresponding to ischemic necrosis of the anterior pituitary related to postpartum haemorrhage. We report three original observations showing an unusual mode of revelation of this syndrome. The first observation is that of a 46-year-old patient admitted initially to resuscitation for a recovered cardiorespiratory arrest, severe hypoglycemia and profound hyponatremia. Read More

    BMP15 "knockout-like" effect in familial premature ovarian insufficiency with persistent ovarian reserve.
    Clin Genet 2017 Aug 30;92(2):208-212. Epub 2017 Mar 30.
    Faculté de Médecine Paris Sud, Université Paris Sud, Université Paris Saclay, Le Kremlin Bicêtre, France.
    Premature ovarian insufficiency (POI) affects 1% to 2% of women under 40 years. Bone morphogenetic protein 15 (BMP15) variants have been described in POI. We studied a family with 2 sisters compound heterozygous for deletions in the BMP15 gene on chromosome Xp11. Read More

    Neuroendocrine carcinoma of the ovotestis: A case report and review of literatures.
    Int J Reprod Biomed (Yazd) 2016 Dec;14(12):783-786
    Department of Obstetrics and Gynecology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
    Background: Neuroendocine carcinoma of the gynecologic tract is rare and poses a significant clinical challenge because of tumor heterogeneity and lack of standardized guidelines for treatment. Ovotestis refers to the histology of a gonad that contains both ovarian follicles and testicular tubular elements. Ovotesticular disorder of sexual development occurs in fewer than 10% of all disorders of sexual development. Read More

    Wide spectrum of NR5A1-related phenotypes in 46,XY and 46,XX individuals.
    Birth Defects Res C Embryo Today 2016 12;108(4):309-320
    Sorahia Domenice, Aline Zamboni Machado, Bruno Ferraz-de-Souza, Antonio Marcondes Lerario, Mirian Yumie Nishi, Nathalia Lisboa Gomes, Thatiana Evelin da Silva, Rosana Barbosa Silva, Luciana R. Montenegro, Amanda Narciso, Elaine Maria Frade Costa, and Berenice Bilharinho Mendonca are from the Laboratório de Hormônios e Genética Molecular (LIM/42), Unidade de Endocrinologia do Desenvolvimento, Disciplina de Endocrinologia e Metabologia do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil.
    Steroidogenic factor 1 (NR5A1, SF-1, Ad4BP) is a transcriptional regulator of genes involved in adrenal and gonadal development and function. Mutations in NR5A1 have been among the most frequently identified genetic causes of gonadal development disorders and are associated with a wide phenotypic spectrum. In 46,XY individuals, NR5A1-related phenotypes may range from disorders of sex development (DSD) to oligo/azoospermia, and in 46,XX individuals, from 46,XX ovotesticular and testicular DSD to primary ovarian insufficiency (POI). Read More

    Evaluation of a new, low-dose levonorgestrel intrauterine contraceptive system over 5 years of use.
    Eur J Obstet Gynecol Reprod Biol 2017 Mar 20;210:22-28. Epub 2016 Nov 20.
    Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, CA, USA.
    Objective: To evaluate the efficacy and safety of a new, low-dose levonorgestrel intrauterine contraceptive system (LNG-IUS 12) for up to 5 years of use.

    Study Design: In this Phase III study, 2885 nulliparous and parous women aged 18-35 years were randomized to LNG-IUS 8 or LNG-IUS 12 for 3 years. After 3 years, women using LNG-IUS 12 could continue for up to 2 additional years (5 years total). Read More

    [Coeliac disease as a possible cause of some gynecological and obstetric abnormalities].
    Ceska Gynekol Winter 2016;81(6):470-476
    Objective: To bring a review of available literature sources on the prevalence of coeliac disease and its possible impact on gynecological and obstetric disorders.

    Design: Review article.

    Setting: Gynecology and Obstetrics Clinic, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia. Read More

    A single-arm phase III study exploring the efficacy and safety of LNG-IUS 8, a low-dose levonorgestrel intrauterine contraceptive system (total content 13.5 mg), in an Asia-Pacific population.
    Contraception 2017 Apr 29;95(4):371-377. Epub 2016 Nov 29.
    Bayer HealthCare Pharmaceuticals, Seoul, Republic of Korea. Electronic address:
    Objective: The objective was to evaluate the efficacy and safety of a low-dose levonorgestrel intrauterine system with total content 13.5 mg (average approximately 8 μg/24 h over the first year; LNG-IUS 8; Jaydess®) in an Asia-Pacific population.

    Study Design: An open-label, single-arm phase III study conducted at 25 centers in China, Australia and Korea assessed LNG-IUS 8 use over 3 years in nulliparous and parous women (N=1114) aged 18-40 years with regular menstrual cycles (21-35 days). Read More

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