2,818 results match your criteria Amenorrhea Secondary


Polycystic Ovary Syndrome Phenotype D Versus Functional Hypothalamic Amenorrhea With Polycystic Ovarian Morphology: A Retrospective Study About a Frequent Differential Diagnosis.

Front Endocrinol (Lausanne) 2022 2;13:904706. Epub 2022 Jun 2.

Clinical Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.

The two most frequent causes of secondary amenorrhea are polycystic ovary syndrome (PCOS) and functional hypothalamic amenorrhea (FHA). Despite several studies showing differences in hormonal profile between these groups, the differential diagnosis remains challenging, in particular between FHA women with polycystic ovarian morphology (FHA-PCOM) and PCOS patients without hyperandrogenism (phenotype D, PCOS-D). In a retrospective case-control study, 58 clearly defined patients with FHA-PCOM were compared to 58 PCOS-D patients, matched 1:1 for age and BMI. Read More

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Urinary retention unveiling deeply embedded multiple leiomyomas in women with Mayer-Rokitansky-Kuster-Hauser syndrome and its successful laparoscopic management: a case-report and literature review.

J Surg Case Rep 2022 Jun 16;2022(6):rjac291. Epub 2022 Jun 16.

Obstetrics and Gynecology Department, Paras Hospital, Gurugram 122002, India.

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the second most common cause of primary amenorrhea with an incidence of 1:4000-5000 women. It is characterized by aplasia or hypoplasia of the uterus and the upper two-thirds of the vagina with normal ovaries and tubes and a normal secondary sexual characteristics. The occurrence of leiomyoma is common but it is rare to have leiomyoma in uterine remnant in MRKH syndrome. Read More

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Complete gonadal dysgenesis analysis in the population of Latvia: malignant outcomes and a review of literature.

Med Pharm Rep 2022 Jan 31;95(1):47-53. Epub 2022 Jan 31.

Department of Pediatrics, Faculty of Medicine, Riga Stradins University, Riga, Latvia.

Background And Aim: Complete gonadal dysgenesis or Swyer syndrome is a rare genetic disorder characterized by 46,XY karyotype and female phenotype with undeveloped streak gonads and high malignancy risk. The condition usually manifests in teenage and young adults with delayed puberty and primary amenorrhea. The purpose of this study was to investigate the incidence and potential malignant outcomes of complete gonadal dysgenesis in Latvia. Read More

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January 2022

Factors associated with delayed diagnosis among Filipino pediatric brain tumor patients: a retrospective review.

CNS Oncol 2022 Jun 9:CNS89. Epub 2022 Jun 9.

Departments of Pediatrics & Neurosciences, Division of Pediatric Neurology, University of the Philippines - Philippine General Hospital, Manila, Philippines.

Determine delayed diagnosis measured by prediagnostic symptomatic interval (PSI) among Filipino pediatric brain tumor patients and identify associated factors. Data was collected retrospectively on Philippine General Hospital pediatric brain tumor patients from 2015 to 2019. PSI was calculated. Read More

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Risk of preeclampsia among women living in coastal areas impacted by sargassum strandings on the French Caribbean island of Martinique.

Environ Toxicol Pharmacol 2022 Jun 6;94:103894. Epub 2022 Jun 6.

Cardiovascular Research Team EA7525, Université des Antilles University of the French West Indies, Fort de France 97200, France; Department of Cardiology, CHU Martinique, University Hospital of Martinique, Fort-de-France 97261, France. Electronic address:

Objective: To investigate preeclampsia risk of pregnant women living in coastal areas regularly impacted by massive sargassum strandings.

Design: Retrospective cohort study SETTINGS AND POPULATION: Pregnant women (n = 3020), seen at the University Hospital of Martinique, were included between 25/01/2016 and 31/07/2020.

Methods: Patient records were retrospectively reviewed. Read More

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Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism.

Case Rep Obstet Gynecol 2022 19;2022:4655249. Epub 2022 May 19.

Department of Obstetrics and Gynecology, Lucerne Cantonal Hospital, Switzerland.

Thalassaemic syndromes are among the most common haemoglobinopathies and are associated with high morbidity and mortality. Because of the various treatments, a secondary endocrinopathy due to iron overload-haemosiderosis-can occur, causing hypopituitarism leading to hypogonadotropic hypogonadism (HH) and infertility. We present a case of secondary amenorrhoea in a patient with beta-thalassaemia and a history of multiple therapies in her adolescence, such as multiple transfusions, chemotherapy, and allogeneic bone marrow transplantation, who presented with HH and premature ovarian insufficiency. Read More

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Interventions for heavy menstrual bleeding; overview of Cochrane reviews and network meta-analysis.

Cochrane Database Syst Rev 2022 05 31;5:CD013180. Epub 2022 May 31.

Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

Background: Heavy menstrual bleeding (HMB) is excessive menstrual blood loss that interferes with women's quality of life, regardless of the absolute amount of bleeding. It is a very common condition in women of reproductive age, affecting 2 to 5 of every 10 women. Diverse treatments, either medical (hormonal or non-hormonal) or surgical, are currently available for HMB, with different effectiveness, acceptability, costs and side effects. Read More

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Endometritis - Diagnosis,Treatment and its impact on fertility - A Scoping Review.

JBRA Assist Reprod 2022 May 27. Epub 2022 May 27.

Department of Obstetrics and Gynaecology All India Institute of Medical Sciences New Delhi India Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India.

Endometritis is defined as an infection or inflammation of the endometrium. Endometritis is of two types: acute and chronic. Acute endometritis is the symptomatic acute inflammation of the endometrium, which upon examination with a microscope shows micro-abscess and neutrophil invasion in the superficial endometrium. Read More

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Reversibility of testosterone-induced acyclicity after testosterone cessation in a transgender mouse model.

F S Sci 2021 05 4;2(2):116-123. Epub 2021 Feb 4.

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA; Division of Reproductive Endocrinology and Infertility, University of Michigan, Ann Arbor, Michigan, USA; Department of Urology, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

Objective: To establish if the cessation of testosterone (T) therapy reverses T-induced acyclicity in a transgender mouse model that allows for well-defined T cessation timing.

Design: Experimental laboratory study using a mouse model.

Setting: University-based basic science research laboratory. Read More

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New STAG3 gene variant as a cause of premature ovarian insufficiency

Rev Colomb Obstet Ginecol 2022 03 30;73(1):142-148. Epub 2022 Mar 30.

Universidad de Antioquia, Medellín (Colombia).

Objectives: To describe a case of ovarian failure secondary to a homozygous pathogenic variant in the STAG3 gene not previously reported. Materials and Methods: A 16-year-old patient with primary amenorrhea and absence of secondary sexual characteristics, with documented autoimmune hypothyroidism, poor genital and gonadal streak development which prompted the performance of clinical exome sequencing. A homozygous pathogenic variant not previously reported in the STAG3 gene, which has been associated with premature ovarian insufficiency (POI), was identified. Read More

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Primary amenorrhea secondary to imperforate hymen.

Clin Case Rep 2022 Apr 26;10(4):e05786. Epub 2022 Apr 26.

Radiology Department Mohammed Vth Military Hospital Rabat Morocco.

Hymen imperforation is uncommon. Symptoms include primary amenorrhea, cyclical lower abdominal pain, and rarely a pelvic mass syndrome. Delayed discovery may lead to endometriosis and infertility. Read More

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Aggressive giant prolactinoma: a case report.

J Med Case Rep 2022 Apr 30;16(1):170. Epub 2022 Apr 30.

Endocrinology Unit, Medical Department, Sarawak General Hospital, Kuching Sarawak, Malaysia.

Background: Managing treatment-resistant aggressive giant prolactinoma can be challenging, as the diagnosis is often complex, and treatment beyond dopamine agonists, surgery, and radiotherapy is limited.

Case Presentation: A 21-year-old Malay woman first presented to our hospital at the age of 16 years with 1-year history of reduced vision and 2 years of amenorrhea. Her baseline prolactin level was 255,894 µIU/mL with secondary hypogonadism, and pituitary magnetic resonance imaging revealed a giant prolactinoma (2. Read More

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Nutritional Concerns among Female International Volunteers Based on the Income and Development Status of Their Country of Service.

Int J Environ Res Public Health 2022 04 16;19(8). Epub 2022 Apr 16.

Department of Nutrition, Dietetics and Food Sciences, College of Life Sciences, Brigham Young University, Provo, UT 84602, USA.

This study aimed to determine the prevalence of female athlete triad risk factors among female international volunteers based on the development and income status of their country of service. A total of 2164 past volunteers completed a retrospective survey. Countries' income and development statuses were coded using the respective annual United Nations World Economic Situations and Prospects reports. Read More

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Case report: Birth achieved after effective ovarian stimulation combined with dexamethasone in a patient with resistant ovary syndrome.

J Ovarian Res 2022 Apr 7;15(1):42. Epub 2022 Apr 7.

Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background: Resistant ovary syndrome (ROS) is a rare endocrine disorder and there have been few reports of live births by affected patients. As gonadotropin resistance leads immature oocytes, some researchers reported few live births with in vitro maturation (IVM) of oocytes, but IVM is not always successful in ROS patients. Here, we report an original case of ROS, associated with Ig-FSHR in the serum, who achieved a live birth following ovarian stimulation combined with dexamethasone treatment. Read More

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Biallelic mutations in PSMC3IP are associated with secondary amenorrhea: expanding the spectrum of premature ovarian insufficiency.

J Assist Reprod Genet 2022 May 29;39(5):1177-1181. Epub 2022 Mar 29.

Research Center for Reproductive Medicine, Unit of Gynecological Endocrinology and Menopause, IRCCS San Matteo Foundation, Pavia, Italy.

Premature ovarian insufficiency (POI) has a strong genetic component, but, in most cases, the etiology remains unidentified. PSMC3IP is an autosomal recessive gene for POI and ovarian dysgenesis, and so far, biallelic mutations in this gene have been described in only four independent families, with all affected members showing primary amenorrhea. Here, we report on the first family with recessive variants in the PSMC3IP gene and POI in a patient with secondary amenorrhea. Read More

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Reporte de caso: hipoglucemia grave como manifestación tardía de síndrome de Sheehan.

Cir Cir 2022 ;90(2):262-266

Departamento de Ciencias de la Salud, Universidad de Sonora. Ciudad Obregón, Sonora, México.

Background: Sheehan's syndrome is a hypopituitarism secondary to necrosis of the pituitary gland caused by massive postpartum bleeding. The presentation is frequently amenorrhea and agalactia; hypoglycemia as a solitary presentation is uncommon.

Case Report: 68-year-old female with a history of postpartum hemorrhage 35 years ago. Read More

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Severe Hyperthyroidism and Complete Hydatidiform Mole in Perimenopausal Woman: Case Report and Literature Review.

Cureus 2022 Feb 15;14(2):e22240. Epub 2022 Feb 15.

Division of Endocrinology, Diabetes and Metabolism, Centro Hospitalar e Universitário do Porto, Porto, PRT.

Gestational trophoblastic disease (GTD) represents a heterogeneous group of disorders within placental trophoblastic cells that are rather rare in perimenopausal ages. One of its complications is the development of secondary clinical hyperthyroidism, which can be potentially complicated if not properly and early recognized. We report the case of a 50-year-old perimenopausal woman, gravida 2 para 2, who presented to the emergency department with severe acute lower abdominal pain and abnormal uterine bleeding for one month. Read More

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February 2022

[Clinical Characterization of Patients with Ovarian Mass Combined with Dysplasia of Secondary Sexual Characteristics].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2022 Feb;44(1):17-23

Department of Obstetrics and Gynecology,National Clinical Research Center for Obstetric and Gynecologic Diseases,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Objective To investigate the clinical characteristics of preadolescent and adolescent female patients with ovarian mass combined with dysplasia of secondary sexual characteristics. Methods This study retrospectively analyzed 18 cases of ovarian mass combined with dysplasia of secondary sexual characteristics aged 0-19 years admitted to Peking Union Medical College Hospital from January 2012 to November 2019.By analyzing the clinical manifestations,surgical methods,postoperative pathology,therapies and prognosis of the cases,we summarized the diagnosis and treatment ideas. Read More

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February 2022

Gonadal Status and Sexual Function at Long-Term Follow-up after Allogeneic Stem Cell Transplantation in Adult Patients with Sickle Cell Disease.

Exp Clin Transplant 2022 Mar 15. Epub 2022 Mar 15.

From the Department of Hematology, Adana Adult Bone Marrow Transplantation Center, Baskent University School of Medicine, Ankara, Turkey.

Objectives: Patients with adult sickle cell disease and severe sequelae are treated with nonmyeloablative allogeneic hematopoietic stem cell transplant. So far, data on gonadal effects are lacking for older cured patients. We assessed the gonadal reserve and sexual function of patients cured of sickle cell disease with transplant and with anti-T-lymphocyte globulin and posttransplant cyclophosphamide-containing regimen within the context of the Baskent Organ Damage Mitigation and Medical Care Development Program. Read More

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The evaluation of ovarian function in normosmic idiopathic hypogonadotropic hypogonadism with a fibroblast growth factor receptor 1 mutation: a case report.

Gynecol Endocrinol 2022 Apr 11;38(4):350-353. Epub 2022 Mar 11.

Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.

Normosmic idiopathic hypogonadotropic hypogonadism (nIHH) is a rare disorder with pubertal delay, normal sense of smell. nIHH with a fibroblast growth factor receptor 1 mutation is much more common in adult males but is rarely reported in females. In addition, the assessment and monitoring of ovarian function in nIHH females has often been ignored. Read More

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Panhypopituitarism Presents As Amenorrhea Secondary to Post Traumatic Stress Disorder in a 33-Year-Old Patient: A Case Report.

Cureus 2022 Mar 3;14(3):e22812. Epub 2022 Mar 3.

Medicine, New York Institute of Technology College of Osteopathic Medicine (NYITCOM), Old Westbury, USA.

Hormonal derangements should be suspected whenever a patient experiences amenorrhea with no abnormal physical exam findings. Clinical suspicion is increased if she also reports psychological trauma that could affect her nervous system and, by association, her hormones since the pituitary gland is present in the brain. Additional exams that aid in the diagnosis of amenorrhea include a variety of blood panels and imaging scans. Read More

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[Mayer-Rokitansky-Küster-Hauser syndrome: a cause of primary amenorrhea: about a case].

Pan Afr Med J 2021 23;40:260. Epub 2021 Dec 23.

Service de Radiologie, Hôpital d'Instruction Militaire Rabat, Rabat, Maroc.

Mayer-Rokitansky -Küster -Hauser syndrome (MRKH) is a rare cause of primary amenorrhea. It is defined as congenital aplasia of the uterus and of the upper two thirds of the vagina in women with normal development of secondary sexual characteristics. Diagnosis is essentially based on magnetic resonance imaging (MRI). Read More

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Novel bone morphogenetic protein 15 (BMP15) gene variants implicated in premature ovarian insufficiency.

Reprod Biol Endocrinol 2022 Mar 1;20(1):42. Epub 2022 Mar 1.

Gynecology Departments, Eastern Azerbaijan ACECR ART Center, Eastern Azerbaijan Branch of ACECR, Tabriz, Iran.

Background: Bone morphogenetic protein 15 (BMP15) is expressed in oocytes and plays a crucial role in the reproduction of mono-ovulating species. In humans, BMP15 gene mutations lead to imperfect protein function and premature ovarian insufficiency. Here we investigated the BMP15 gene variants in a population of Iranian women with premature ovarian insufficiency. Read More

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Clinical Spectrum and Causes of Delayed Puberty Among Patients Presenting to the Endocrine Clinic at Jinnah Postgraduate Medical Centre.

Cureus 2022 Jan 24;14(1):e21574. Epub 2022 Jan 24.

Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Introduction: It has been observed that 5% of adolescents are affected by pubertal timing disorders. However, there is limited data about this in Pakistan. This cross-sectional study aimed to observe the patterns and causes of delayed puberty (DP) among patients presenting at the endocrine clinic of a tertiary care hospital in Karachi. Read More

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January 2022

Identification of Novel Compound Heterozygous Variants of the Gene in Boucher-Neuhäuser Syndrome.

Front Genet 2022 7;13:810537. Epub 2022 Feb 7.

Department of Endocrinology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Boucher-Neuhäuser syndrome (BNS, MIM 215470) is a rare autosomal recessive syndrome caused by mutations in the gene. Few BNS cases have been reported for functional validation at the RNA level. Herein, we report on the family of a 17-year-old girl with clinical characteristics of BNS, genetic validation, and a systematic review of variants related to BNS. Read More

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February 2022

Knowledge and use of lactational amenorrhoea as a family planning method among adolescent mothers in Uganda: a secondary analysis of Demographic and Health Surveys between 2006 and 2016.

BMJ Open 2022 02 22;12(2):e054609. Epub 2022 Feb 22.

Department of Public Health, Institute of Tropical Medicine, Antwerpen, Belgium.

Objective: To assess the level of knowledge and use of the lactational amenorrhoea method (LAM) among adolescents in Uganda between 2006 and 2016 using nationally representative data from Demographic and Health Surveys (DHS).

Design: Cross-sectional design involving analysis of three DHS (2006, 2011, and 2016) in Uganda.

Setting: The data collection took place in Uganda. Read More

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February 2022

Comparison of Herbal Medicines Used for Women's Menstruation Diseases in Different Areas of the World.

Front Pharmacol 2021 4;12:751207. Epub 2022 Feb 4.

School of Pharmacy, South-Central University for Nationalities, Wuhan, China.

This review aims to compare the use of herbal medicine used to treat women's menstruation and the prevalence of menstrual diseases in different regions, which reveal the use of herbal medicine globally and provide scientific guidance for improving women's health. The information available on herbal medicines for women between the years 2000 and 2021 was systematically collected the library and electronic search systems such as Google Scholar, PubMed, ScienceDirect, and Web of Science as well as secondary resources including books and conference proceedings. Totally, 571 ethnic medicines commonly used for women's menstruation health in Asia, Europe, Oceania, Africa, and America were accounted. Read More

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February 2022

Long-term follow-up of a randomized controlled trial comparing systemic family therapy (FT-S) added to treatment as usual (TAU) with TAU alone in adolescents with anorexia nervosa.

J Child Psychol Psychiatry 2022 Feb 18. Epub 2022 Feb 18.

Adolescents and Young Adults Psychiatry Unit, Institut Mutualiste Montsouris, Paris, France.

Background: Randomized controlled trials showed the efficacy of family therapy for anorexia nervosa during adolescence, but studies examining its long-term beneficial effect are still needed. This article presents the results of a 54-month post-randomization follow-up of a previously reported randomized controlled trial that compared two post-hospitalization outpatient treatment programs: Treatment As Usual alone versus Systemic Family Therapy added to Treatment As Usual.

Methods: A consecutive series of 60 female adolescents with anorexia nervosa (DSM-IV) were randomized (30 per group). Read More

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February 2022

Prevalence of Female Athlete Triad Risk Factors among Female International Volunteers and College Age-Matched Controls.

Int J Environ Res Public Health 2022 01 22;19(3). Epub 2022 Jan 22.

Department of Nutrition, Dietetics & Food Sciences, College of Life Sciences, Brigham Young University, Provo, UT 84602, USA.

This study retrospectively compared the prevalence of factors related to the female athlete triad (low energy availability, secondary amenorrhea (SA), low bone mineral density (BMD)), and post-study BMD of female college students and female international volunteer missionaries (volunteers). Female college students (21-26 years) completed a survey that retrospectively assessed an 18-month study period (volunteer service or first 18 months of college); Diet History Questionnaire III (DHQ III) and Dual-Energy X-ray Absorptiometry (DXA) scan were optional. One-way ANOVAs and chi-squared distributions assessed group differences. Read More

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January 2022