2,529 results match your criteria Amenorrhea Secondary


Effects of birth spacing on adverse childhood health outcomes: evidence from 34 countries in sub-Saharan Africa.

J Matern Fetal Neonatal Med 2019 Feb 10:1-8. Epub 2019 Feb 10.

d Centre for Actuarial Research, (CARe), Faculty of Social Sciences , University of Cape Town , Cape Town , South Africa.

Background: Interpregnancy intervals (IPI) are independently associated with maternal, perinatal, infant and child outcomes. Birth spacing is a recommended tool to reduce adverse health outcomes especially among children. This study aims to determine the prevalence of adverse child health outcomes in sub-Saharan Africa (SSA) countries and to examine the association between the length of preceding birth interval child health outcomes. Read More

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http://dx.doi.org/10.1080/14767058.2019.1576623DOI Listing
February 2019
2 Reads

Assessment of Dietary Intake, Energy Status, and Factors Associated With RED-S in Vocational Female Ballet Students.

Front Nutr 2018 9;5:136. Epub 2019 Jan 9.

Faculty of Health Science and Sport, University of Stirling, Stirling, United Kingdom.

Elite ballet dancers are at risk of health issues associated with Relative Energy Deficiency in Sport (RED-S). This study determined the nutritional status, estimated energy status, and assessed factors related to RED-S in vocational female ballet students. Using a cross-sectional study design, we measured dietary intake (food diaries and 24 h dietary-recall) and energy expenditure (accelerometry) in vocational female ballet students ( = 20; age: 18. Read More

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http://dx.doi.org/10.3389/fnut.2018.00136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333673PMC
January 2019
1 Read

Energy Availability in Athletics: Health, Performance and Physique.

Int J Sport Nutr Exerc Metab 2019 Jan 11:1-35. Epub 2019 Jan 11.

5 Department of Family Medicine. McMaster University, Hamilton, Canada.

The reported prevalence of low energy availability (LEA) in female and male track and field athletes is between 18-58% with the highest prevalence among athletes in endurance and jump-events. In male athletes, LEA may result in reduced testosterone levels and libido along with impaired training capacity. In female track and field athletes, functional hypothalamic amenorrhea (FHA) as consequence of LEA has been reported among 60% of elite middle- and long-distance athletes and 23% among elite sprinters. Read More

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http://dx.doi.org/10.1123/ijsnem.2018-0201DOI Listing
January 2019
3 Reads

Whole-exome sequencing reveals SALL4 variants in premature ovarian insufficiency: an update on genotype-phenotype correlations.

Hum Genet 2019 Jan 2;138(1):83-92. Epub 2019 Jan 2.

Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), School of Life Sciences, Fudan University, Shanghai, 200011, China.

Premature ovarian insufficiency (POI) is a severe female disorder characterized by primary or secondary amenorrhea before 40 years of age. Genetic factors have been implicated in the pathogenesis of POI, but known POI-associated genes account for only a small fraction of heritability. Here, we performed whole-exome sequencing (WES) to explore pathogenic genes in Han Chinese subjects with POI. Read More

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http://dx.doi.org/10.1007/s00439-018-1962-4DOI Listing
January 2019
2 Reads

Phenotypic variations in X chromosome mutations: Two case reports.

Case Rep Womens Health 2019 Jan 7;21:e00084. Epub 2018 Nov 7.

Program in Reproductive Endocrinology and Gynecology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.

Turner syndrome (TS) affects 1 in 2500 females. Monosomy X is the most common etiology, classically presenting with hypoestrogenemia and short stature. We present two cases of partial X chromosome deletions that do not reflect the typical phenotype of TS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22149112183011
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http://dx.doi.org/10.1016/j.crwh.2018.e00084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305762PMC
January 2019
5 Reads

Medical and surgical abortion for women living with HIV.

Cochrane Database Syst Rev 2018 12 19;12:CD012834. Epub 2018 Dec 19.

Department of International Health, Social and Behavioral Interventions Program, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Suite E5033, Baltimore, Maryland, USA, 21205.

Background: The World Health Organization (WHO) guidelines for safe abortion recommend medical abortion with mifepristone and misoprostol or surgical abortion with vacuum aspiration or dilation and evacuation as safe and effective options for women. However, no specific clinical considerations are stipulated within these guidelines for women living with HIV. Concerns have been raised that women living with HIV may be at greater risk of adverse abortion outcomes compared to HIV-uninfected women due to immunosuppression, high rates of co-infection with other sexually transmitted infections, and possible contraindications between medications used for medical abortion and antiretroviral therapy regimens. Read More

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http://doi.wiley.com/10.1002/14651858.CD012834.pub2
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http://dx.doi.org/10.1002/14651858.CD012834.pub2DOI Listing
December 2018
8 Reads

Vascular and cognitive effects of cocoa-rich chocolate in postmenopausal women: a study protocol for a randomised clinical trial.

BMJ Open 2018 Dec 14;8(12):e024095. Epub 2018 Dec 14.

Primary Health Care Research Unit, La Alamedilla Health Center, Institute of Biomedical Research of Salamanca (IBSAL), Health Service of Castilla y León (SACyL), Salamanca, Spain.

Introduction: The intake of polyphenols has certain health benefits. This study will aim to assess the effect of adding a daily amount of chocolate high in cocoa content and polyphenols to the normal diet on blood pressure, vascular function, cognitive performance, quality of life and body composition in postmenopausal women.

Methods And Analysis: Here we plan a randomised clinical trial with two parallel groups involving a total of 140 women between 50 and 64 years in the postmenopausal period, defined by amenorrhoea of ​​at least 12 consecutive months. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02409
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http://dx.doi.org/10.1136/bmjopen-2018-024095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303642PMC
December 2018
9 Reads

Resumption of Ovarian Function After Ovarian Biopsy/Scratch in Patients With Premature Ovarian Insufficiency.

Reprod Sci 2018 Dec 12:1933719118818906. Epub 2018 Dec 12.

1 Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.

To evaluate the effect of ovarian biopsy and scratch on the resumption of ovarian function in women with premature ovarian insufficiency (POI), the follicle development and pregnancy outcome were retrospectively analyzed in women with POI after ovarian biopsy/scratch. Eighty patients with POI with secondary amenorrhea were accepted the laparoscopic surgery, and then hormone replacement treatment for 6 months was applied and in vitro fertilization and embryo transfer was suggested. No significant difference in clinical characteristics was observed before and after ovarian biopsy/scratch ( P > . Read More

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http://dx.doi.org/10.1177/1933719118818906DOI Listing
December 2018
2 Reads

[Eating disorders and fertility].

Psychiatr Hung 2018 ;33(4):331-339

Semmelweis Egyetem, Magatartástudomanyi Intezet, Budapest, Hungary, E-mail:

Common gynecological complications of various eating disorders include infertility, unwanted pregnancy, miscarriage, sexual dysfunction and complications in the treatment of gynecological cancers. Women with eating disorders typically see their gynecologists because of menstrual and other endocrine disorders or unexplained gastrointestinal symptoms, and often report on psychological symptoms (anxiety, depression or decreased libido). In spite of anovulation, menstruation may occur and ovulation without menstruation may be possible, which may lead to an increased incidence of unwanted pregnancies in case of prior or current eating disorders. Read More

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January 2018
1 Read

Predicting Menstrual Recovery in Adolescents With Anorexia Nervosa Using Body Fat Percent Estimated by Bioimpedance Analysis.

J Adolesc Health 2018 Dec 5. Epub 2018 Dec 5.

Exercise, Nutrition and Lifestyle Clinic, The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Ramat-Gan, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Objective: To identify the threshold of total body fat percentage (TBF%) required for the resumption of menses (ROM) in hospitalized female adolescents with anorexia nervosa (AN) using bioimpedance analysis (BIA).

Methods: All female adolescents hospitalized with AN in our medical center were evaluated in a longitudinal prospective study during the years of 2012-2017. Anthropometric data, body fat measured by BIA, and hormonal determinants were collected periodically, in addition to routine medical and gynecological assessments. Read More

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http://dx.doi.org/10.1016/j.jadohealth.2018.10.008DOI Listing
December 2018
2 Reads

Vilaprisan in women with uterine fibroids: the randomized phase 2b ASTEROID 1 study.

Fertil Steril 2019 Feb 7;111(2):240-248. Epub 2018 Dec 7.

Bayer, Berlin, Germany.

Objectives: To assess the safety and efficacy of four vilaprisan doses (0.5-4.0 mg) in women with uterine fibroids. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2018.10.012DOI Listing
February 2019
1 Read
4.590 Impact Factor

Similarities and differences in the reproductive phenotypes of women with congenital hypogonadotrophic hypogonadism caused by GNRHR mutations and women with polycystic ovary syndrome.

Hum Reprod 2019 Jan;34(1):137-147

University of Paris-Sud and University Paris-Saclay, Le Kremlin-Bicêtre, France.

Study Question: Does the phenotype of women with normosmic congenital hypogonadotrophic hypogonadism (nCHH) and pituitary resistance to GnRH caused by biallelic mutations in the GnRH receptor (GNRHR) (nCHH/bi-GNRHR) differ from that of women with polycystic ovary syndrome (PCOS)?

Summary Answer: Women with nCHH/bi-GNRHR have variable pubertal development but nearly all have primary amenorrhea and an exaggerated LH response to GnRH stimulation, similar to that seen in women with PCOS.

What Is Known Already: Women with nCHH/bi-GNRHR are very rare and their phenotype at diagnosis is not always adequately documented. The results of gonadotrophin stimulation by acute GnRH challenge test and ovarian features have not been directly compared between these patients and women with PCOS. Read More

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https://academic.oup.com/humrep/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/humrep/dey339DOI Listing
January 2019
10 Reads

Vesicouterine Fistula (VUF) as a Rare Urogenital Complication Managed with Delayed Surgical Repair: A Case Report and Review of the Literature.

Case Rep Obstet Gynecol 2018 24;2018:2394896. Epub 2018 Oct 24.

Department of Urology, 424 General Military Hospital of Thessaloniki, Thessaloniki, Greece.

Vesicouterine fistula (VUF) represents a rare urogenital complication. It is considered to be the least common type of urogenital fistulas. Iatrogenic reasons have been shown to be the most prominent cause, with lower segment caesarean section accounting for approximately two-thirds of the cases. Read More

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https://www.hindawi.com/journals/criog/2018/2394896/
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http://dx.doi.org/10.1155/2018/2394896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220400PMC
October 2018
16 Reads

Female Pseudo Hermaphroditism: Late Onset Congenital Adrenal Hyperplasia.

J Ayub Med Coll Abbottabad 2018 Jul-Sep;30(3):458-462

Department of Obstetrics and Gynaecology, Foundation University Medical College /Fauji Foundation Hospital Rawalpindi, Pakistan.

Non-classic congenital adrenal hyperplasia is a genetic condition caused by deficiency of 21- hydroxylase deficiency (NCAH). It is a milder and later onset form of a genetic condition known as congenital adrenal hyperplasia. We present four cases of non-classical congenital adrenal hyperplasia presented in gynae OPD foundation university medical college Fauji foundation hospital from Jan 2016 to March 2017. Read More

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January 2019
19 Reads

Luteal phase stimulation, the future of fertility preservation? Retrospective cohort study of luteal phase versus follicular phase stimulation.

J Gynecol Obstet Hum Reprod 2019 Feb 12;48(2):91-94. Epub 2018 Nov 12.

Department of Gynecology, Centre Médico-Chirurgical d'Obstétrique (CMCO), Hôpitaux universitaires de Strasbourg, France.

Research Question: Is luteal phase stimulation capable of improving fertility preservation?

Materials And Methods: We performed a retrospective cohort study of consecutive ovarian stimulations, during July 2012 and September 2018 at Strasbourg University Teaching Hospital in France. Enrollment criteria were patients aged below 40 who had been referred to our center following a diagnosis of cancer or requiring gonadotoxic treatment. All patients enrolled had regular menstrual cycles and normal ovulation. Read More

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http://dx.doi.org/10.1016/j.jogoh.2018.11.003DOI Listing
February 2019
1 Read

Virilising ovarian tumors: a single center experience.

Endocr Connect 2018 Nov 1. Epub 2018 Nov 1.

N Shah, Mumbai, 400012, India.

Aims: Literature on virilising ovarian tumors (VOT) is limited to case reports and series reporting single pathological type. We have analyzed the clinical, hormonal, radiological, histological, management and outcome data of VOT.

Materials And Methods: This retrospective study was conducted at a tertiary health care center from Western India. Read More

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http://dx.doi.org/10.1530/EC-18-0360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280592PMC
November 2018
13 Reads

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey.

J Clin Res Pediatr Endocrinol 2018 Nov 5. Epub 2018 Nov 5.

Objective: We aimed to study the characteristics on admission, diagnosis, treatment, and follow-up of hyperprolactinemic cases in a large multicenter study.

Methods: We reviewed 233 hyperprolactinemic patients under 18 years of age who were followed by different centers. The patients were divided as having microadenomas, macroadenomas, drug-induced hyperprolactinemia, and idiopathic hyperprolactinemia. Read More

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http://cms.galenos.com.tr/Uploads/Article_19906/JCRPE-0-0-En
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http://dx.doi.org/10.4274/jcrpe.0206DOI Listing
November 2018
7 Reads

Rare case of occult testosterone-producing ovarian tumor that was diagnosed by selective venous hormone sampling.

Reprod Med Biol 2018 Oct 21;17(4):504-508. Epub 2018 Jun 21.

Department of Obstetrics and Gynecology Sapporo Medical University School of Medicine Sapporo Japan.

Case: A 32 year old woman was referred because of secondary amenorrhea, hirsutism, and voice deepening.

Outcome: The blood testosterone level was markedly high. A transvaginal ultrasound revealed a small region in the left ovary, but whether or not it was a tumor was unclear. Read More

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http://dx.doi.org/10.1002/rmb2.12213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194242PMC
October 2018
2 Reads

Efficacy of a Herbal Formulation Based on Foeniculum Vulgare in Oligo/Amenorrhea: A Randomized Clinical Trial.

Curr Drug Discov Technol 2018 Oct 29. Epub 2018 Oct 29.

Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.

Background: The aim of this study was to evaluate the efficacy of the herbal tea based on Foeniculum vulgare, on inducing regular bleeding in women with oligomenorrhea and secondary amenorrhea(oligo/amenorrhea).

Methods: Forty women aged 18- 40 with oligo/amenorrhea were enrolled in this randomized controlled clinical trial and were allocated to two groups equally. The women in the first group were treated by Fomentex (Foeniculum vulgare / Mentha longifolia / Vitex agnus-castus) herbal tea 11. Read More

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http://dx.doi.org/10.2174/1570163815666181029120512DOI Listing
October 2018
13 Reads

Consequences of premature ovarian insufficiency on women's sexual health.

Prz Menopauzalny 2018 Sep 30;17(3):127-130. Epub 2018 Sep 30.

Department of Gynaecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland.

Premature ovarian insufficiency (POI) is defined by amenorrhoea and decreased serum levels of oestrogens associated with increased serum gonadotropins concentrations before the age of 40 years. Patients suffering from POI present with irregular menses, either secondary or (less common) primary amenorrhoea, and subfertility. POI affects approximately 1 in 100 women by the age 40 years and 0. Read More

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http://dx.doi.org/10.5114/pm.2018.78557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196782PMC
September 2018
6 Reads

Sex hormone levels by presence and severity of cirrhosis in women with chronic hepatitis C virus infection.

J Viral Hepat 2019 Feb 14;26(2):258-262. Epub 2018 Nov 14.

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Cirrhosis is associated with hormonal dysregulation, as evidenced by secondary amenorrhoea in reproductive-aged women, and feminization of cirrhotic men. Whether hormone levels vary by severity of cirrhosis in women is not known. If identified, such changes may have important clinical relevance, particularly, as low sex hormone binding globulin (SHBG) and follicle stimulating hormone (FSH) are known to promote metabolic and cardiovascular disease in women. Read More

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http://dx.doi.org/10.1111/jvh.13027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345586PMC
February 2019
3 Reads

Delayed hypopituitarism following Russell's viper envenomation: a case series and literature review.

Pituitary 2019 Feb;22(1):4-12

Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, #82, EPIP Area, Whitefield, Bangalore, Karnataka, 560066, India.

Purpose: Hypopituitarism (HP) is an uncommon consequence of Russell's viper envenomation (RVE). Delayed hypopituitarism (DHP) presents months to years after recovering from snake bites (SB). The clinical presentation, manifestations, and outcomes of DHP following RVE have not been systematically studied. Read More

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http://dx.doi.org/10.1007/s11102-018-0915-1DOI Listing
February 2019
4 Reads

Ulipristal Acetate for Treatment of Uterine Leiomyomas: A Randomized Controlled Trial.

Obstet Gynecol 2018 Nov;132(5):1241-1251

Case Western Reserve School of Medicine, Cleveland, Ohio; Medical University of South Carolina, Charleston, South Carolina; Carolina Women's Research & Wellness Center, Durham, North Carolina; Willowbend Health & Wellness, Frisco, Texas; Eastern Virginia Medical School, Norfolk, Virginia; Seattle Women's, Seattle, Washington; Allergan plc, Madison, New Jersey; Allergan plc, Irvine, California; and Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Objective: To assess the efficacy and tolerability of ulipristal acetate, a selective progesterone receptor modulator, for treatment of symptomatic uterine leiomyomas.

Methods: This phase 3, double-blind, double-dummy, placebo-controlled trial randomized premenopausal women (18-50 years) with uterine leiomyomas and abnormal uterine bleeding to once-daily 5 mg ulipristal, 10 mg ulipristal, or placebo in two 12-week treatment courses separated by a drug-free interval of two menses. Coprimary end points were rates of and time to amenorrhea during course 1. Read More

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http://Insights.ovid.com/crossref?an=00006250-900000000-9789
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http://dx.doi.org/10.1097/AOG.0000000000002942DOI Listing
November 2018
13 Reads

Vesicouterine Fistula (Youssef Syndrome): Case Report and Literature Review.

Rev Bras Ginecol Obstet 2018 Sep 19;40(9):563-569. Epub 2018 Sep 19.

Department of Gynecology, Hospital Paulistano, São Paulo, SP, Brazil.

Objective:  To describe a case of vesicouterine fistula and to review the literature related to this condition.

Methods:  For the review, we accessed the MEDLINE, BIREME and LILACS databases; the references of the searched articles were also reviewed.

Results:  A 38-year-old woman, in the 1st day after her 3rd cesarean, presented heavy hematuria, which was considered secondary to a difficult dissection of the bladder. Read More

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http://dx.doi.org/10.1055/s-0038-1666998DOI Listing
September 2018
10 Reads

Knowledge and associated factors of lactational amenorrhea as a contraception method among postpartum women in Aksum town, Tigray Region, Ethiopia.

BMC Res Notes 2018 Sep 3;11(1):641. Epub 2018 Sep 3.

School of Nursing, College of Health Sciences, Mekelle University, Mekelle, Tigray, Ethiopia.

Objectives: The objective of the study was to assess the prevalence of knowledge level and predictors of lactational amenorrhea method (LAM) as method of contraception among women who gave birth a year prior to the study period in the Aksum town, Tigray Region. The study was cross sectional in design conducted from March 25 to April 24, 2015. Results of the study could help the design of family planning strategies. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-018-3754-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122625PMC
September 2018
14 Reads

Postpartum fertility behaviours and contraceptive use among women in rural Ghana.

Contracept Reprod Med 2018 20;3:13. Epub 2018 Aug 20.

2FWACN School of Nursing and Midwifery, University of Ghana, Accra, Ghana.

Background: Although most women would want to wait for more than two years before having another baby, their fertility behaviours during the first year following birth may decrease or increase the length of the birth interval. The objectives of this study were to: assess how protected postpartum women in the Mfantseman municipal were against pregnancy, based on their patterns of amenorrhoea and sexual abstinence; determine the timing of postpartum contraception in relation to amenorrhoea and sexual abstinence; and determine the predictors of postpartum contraceptive use.

Methods: This was a prospective study carried out in the Mfantseman Municipality of the Central region of Ghana. Read More

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http://dx.doi.org/10.1186/s40834-018-0066-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100709PMC
August 2018
15 Reads

Primary pigmented nodular adrenocortical disease (PPNAD) as an underlying cause of symptoms in a patient presenting with hirsutism and secondary amenorrhea: case report and literature review.

Gynecol Endocrinol 2018 Dec 21;34(12):1022-1026. Epub 2018 Aug 21.

a Department of Endocrinology, Metabolism and Internal Medicine , Poznan University of Medical Sciences , Poznan , Poland.

Hypercortisolemia in females may lead to menstrual cycle disturbances, infertility, hirsutism and acne. Herewith, we present a 18-year-old patient, who was diagnosed due to weight gain, secondary amenorrhea, slowly progressing hirsutism, acne and hot flashes. Thorough diagnostics lead to a conclusion, that the symptoms was the first manifestation of primary pigmented nodular adrenocortical disease (PPNAD). Read More

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http://dx.doi.org/10.1080/09513590.2018.1493101DOI Listing
December 2018
5 Reads

Müllerian Agenesis Masquerading as Secondary Amenorrhea.

Case Rep Pediatr 2018 19;2018:6912351. Epub 2018 Jul 19.

Department of General Pediatrics and Adolescent Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

The most common cause of primary amenorrhea is congenital malformation of the Müllerian ducts, including Müllerian agenesis, also known as Mayer-Rokitansky-Küster-Hauser syndrome (MRKH). Most general gynecologists and primary care physicians who see female adolescents will encounter MRKH in their careers. We present the case of an adolescent with MRKH who reported secondary, instead of primary amenorrhea. Read More

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http://dx.doi.org/10.1155/2018/6912351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079514PMC
July 2018
11 Reads

FXPOI: Pattern of AGG Interruptions Does not Show an Association With Age at Amenorrhea Among Women With a Premutation.

Front Genet 2018 3;9:292. Epub 2018 Aug 3.

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, United States.

Fragile X-associated primary ovarian insufficiency (FXPOI) occurs in about 20% of women who carry a premutation allele (55-200 CGG repeats). These women develop hypergonadotropic hypogonadism and have secondary amenorrhea before age 40. A non-linear association with repeat size and risk for FXPOI has been seen in multiple studies women with a premutation: those with a mid-range of repeats are at highest risk (∼70-100 CGG repeats). Read More

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https://www.frontiersin.org/article/10.3389/fgene.2018.00292
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http://dx.doi.org/10.3389/fgene.2018.00292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086008PMC
August 2018
16 Reads

Amenorrhoea in adolescent female athletes.

Lancet Child Adolesc Health 2018 Sep 6;2(9):677-688. Epub 2018 Jul 6.

Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Division of Pediatric Endocrinology, Massachussets General Hospital for Children and Harvard Medical School, Boston, MA, USA.

Female athletes often experience amenorrhoea at various times during training, but this should not be considered normal. Low energy availability is a common cause of menstrual dysfunction, and amenorrhoea can serve as a warning sign of some of the health and performance consequences associated with inadequate energy, including poor bone accrual and low bone mineral density. Adolescence is an important time for bone accrual, growth, and development, making delayed menarche and secondary amenorrhoea particularly concerning in young athletes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23524642183014
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http://dx.doi.org/10.1016/S2352-4642(18)30145-7DOI Listing
September 2018
11 Reads

Pheochromocytoma in Children and Adolescents With Multiple Endocrine Neoplasia Type 2B.

J Clin Endocrinol Metab 2019 Jan;104(1):7-12

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland.

Context: Multiple endocrine neoplasia type 2B (MEN2B) is characterized by early-onset medullary thyroid cancer in virtually all cases and a 50% lifetime risk of pheochromocytoma (PHEO) development. The literature on PHEO in patients with MEN2B is limited with most data being reported from adult studies that primarily address MEN2A.

Objective: The aim of the current study is to describe PHEO development in a cohort of pediatric patients with MEN2B. Read More

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2018-00705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240163PMC
January 2019
18 Reads

Complete androgen insensitivity syndrome in a young woman with metabolic disorder and diabetes: A case report.

Medicine (Baltimore) 2018 Aug;97(33):e11353

Department of Endocrinology & Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine.

Rationale: Androgen insensitivity syndrome (CAIS) is a rare X-linked recessive androgen receptor disorder characterized by complete resistance to the actions of androgen in an individual with 46,XY karyotype. Metabolic disorder and diabetes has been rarely reported in these patients.

Patient Concerns: A 22-year-old female patient was admitted to our center for the evaluation of high blood sugar. Read More

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http://Insights.ovid.com/crossref?an=00005792-201808170-0000
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000011353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112890PMC
August 2018
12 Reads

[17α-Hydroxylase deficiency with severe hypertension as the initial symptom in a child].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Aug;20(8):675-679

Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China.

A 14-year-old female (social gender) patient was admitted to the hospital due to severe hypertension for 11 days. The patient had primary amenorrhea. The blood pressure was 146/90 mm Hg. Read More

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August 2018
7 Reads

Multiorgan system structural malformations associated with Mayer-Rokitansky-Küster-Hauser Syndrome (MRKHS) type 2: avoiding pitfalls in diagnosis, counseling and treatment.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Department of Ob/Gyn, Texas Tech University Health Science Center School of Medicine, Amarillo, Texas, USA.

An 18-year-old virginal woman was referred to the reproductive endocrinology clinic with primary amenorrhoea and secondary sexual development in the absence of pelvic pain. Additionally, she had significant congenital sensorineural hearing loss, autism, bipolar disorder and class III obesity. On physical examination, secondary sexual development was confirmed (Tanner 5 breasts and Tanner 4 pubic hair). Read More

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http://dx.doi.org/10.1136/bcr-2018-225977DOI Listing
July 2018
7 Reads

Florid hyperandrogenism due to a benign adrenocortical adenoma.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Endocrinologist, Centre of Endocrinology Diabetes & Metabolism, Limassol, Cyprus.

A 26-year-old woman with a history of polycystic ovarian syndrome presented with secondary amenorrhea, worsening hirsutism, acne, deepening of voice and unexplained 10-20 kg weight gain. Her Ferriman-Gallway hirsutism score was 12 with cystic facial acne and increased masculine phenotype. Urine Beta-Human Chorionic Gonadotropins (bHCG) was negative. Read More

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http://dx.doi.org/10.1136/bcr-2018-224804DOI Listing
July 2018
13 Reads

Infertility secondary to a pituitary adenoma.

JAAPA 2018 Aug;31(8):26-28

Danielle O'Laughlin practices primary care internal medicine at the Mayo Clinic in Rochester, Minn. The author has disclosed no potential conflicts of interest, financial or otherwise.

Evaluating patients for infertility is common in the primary care setting and can involve multiple differentials and treatment options. This case report describes a 34-year-old woman whose infertility evaluation led to the diagnosis of a pituitary adenoma. Read More

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http://dx.doi.org/10.1097/01.JAA.0000533659.78664.a5DOI Listing
August 2018
1 Read

Clinical and Cytogenetic Study of Egyptian Patients with Sex Chromosome Disorders of Sex Development.

Sex Dev 2018 Jul 14. Epub 2018 Jul 14.

Disorders of sex development (DSD) are conditions with an abnormal development of chromosomal, gonadal, or anatomical sex. Sex chromosome DSD involve conditions associated with either numerical or structural abnormalities of the sex chromosomes. This study included patients comprising a wide spectrum of presenting features suggestive of DSD and aimed at studying the frequency of sex chromosome abnormalities among 108 Egyptian DSD patients who presented to the Clinical Genetics and Endocrinology Clinics, National Research Centre (NRC) over the 2-year period of 2013 and 2014. Read More

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http://dx.doi.org/10.1159/000490840DOI Listing
July 2018
2 Reads

Two rare loss-of-function variants in the STAG3 gene leading to primary ovarian insufficiency.

Eur J Med Genet 2019 Mar 10;62(3):186-189. Epub 2018 Jul 10.

Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Laboratório de Sequenciamento em Larga Escala (SELA), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil. Electronic address:

Background/aim: Primary ovarian insufficiency (POI) is characterized by primary or secondary amenorrhea, infertility, low estradiol levels, and increased gonadotropin levels. Most cases of POI remain unsolved even after exhaustive investigation. Here, we performed a targeted massively parallel sequencing to identify the genetic diagnosis of primary ovarian insufficiency (POI) in a Brazilian patient. Read More

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http://dx.doi.org/10.1016/j.ejmg.2018.07.008DOI Listing
March 2019
7 Reads

Uterine Necrosis after Uterine Artery Embolization for Symptomatic Fibroids.

Case Rep Obstet Gynecol 2018 28;2018:9621741. Epub 2018 May 28.

Department of Obstetrics and Gynaecology, Aga Khan University, Nairobi, Kenya.

Introduction: Uterine artery embolization (UAE) is a minimally invasive intervention that is used in the treatment of fibroids. UAE can lead to complications including postembolization syndrome, postprocedure pain, infection, endometrial atrophy leading to secondary amenorrhea, and uterine necrosis. Uterine necrosis after UAE is very rare and hence poses a clinical dilemma for any clinician in its identification and management. Read More

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https://www.hindawi.com/journals/criog/2018/9621741/
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http://dx.doi.org/10.1155/2018/9621741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994572PMC
May 2018
5 Reads

The association between menstrual cycle pattern and hysteroscopic march classification with endometrial thickness among infertile women with Asherman syndrome.

Medicine (Baltimore) 2018 Jul;97(27):e11314

Department of Obstetrics and Gynecology, Women's Specialized Hospital, King Fahad Medical City, Riyadh.

Women with Asherman syndrome (AS) have intrauterine adhesions obliterating the uterine cavity. Hysteroscopic March classification describes the adhesions which graded in terms of severity. This study has been designed to assess the prevalence and association between of clinical presentations, potential causes, and hysteroscopic March classification of AS among infertile women with endometrial thickness. Read More

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http://Insights.ovid.com/crossref?an=00005792-201807060-0003
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http://dx.doi.org/10.1097/MD.0000000000011314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076072PMC
July 2018
8 Reads

Early medical abortion with self-administered low-dose mifepristone in combination with misoprostol.

J Obstet Gynaecol Res 2018 Sep 5;44(9):1705-1711. Epub 2018 Jul 5.

Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory for Reproduction and Genetics of Guangdong Higher-Education Institutes, Guangzhou Institute of Obstetrics and Gynecology, Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Aim: The aim of the present study was to investigate the safety and efficacy of low-dose mifepristone combined with self-administered misoprostol for termination of early pregnancy.

Methods: A total of 533 women seeking medical abortion in early pregnancy (≤49 days since the last menstrual period) were divided randomly into hospital- (H-Mis, 250) and self- (S-Mis, 283) administered misoprostol groups. Women in two groups took 100 mg of oral mifepristone in hospital followed by 200 μg of sublingual misoprostol 24 h later in hospital or home. Read More

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http://dx.doi.org/10.1111/jog.13716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175481PMC
September 2018
2 Reads

Noncytotoxic-Related Primary Ovarian Insufficiency in Adolescents: Multicenter Case Series and Review.

J Pediatr Adolesc Gynecol 2018 Dec 27;31(6):597-604. Epub 2018 Jun 27.

Medstar Health, Division of Pediatric and Adolescent Gynecology, Departments of OB/GYN and Pediatrics, Washington, DC.

Study Objective: Primary ovarian insufficiency (POI) in adolescents not due to cytotoxic therapy has not been well studied. Causes of POI have been described in adults, but adolescents might represent a unique subset necessitating a targeted approach to diagnosis, workup, and treatment. We sought to better characterize adolescent POI through a descriptive multicenter study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10833188183024
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http://dx.doi.org/10.1016/j.jpag.2018.06.006DOI Listing
December 2018
6 Reads
1.810 Impact Factor

Prolactin-Producing Pituitary Carcinoma, Hypopituitarism, and Graves' Disease-Report of a Challenging Case and Literature Review.

Front Endocrinol (Lausanne) 2018 6;9:312. Epub 2018 Jun 6.

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João, Porto, Portugal.

Introduction: The diagnosis of pituitary carcinoma is very rare, requires the evidence of metastatic disease, and has a poor overall survival. Malignant prolactinoma frequently requires dopamine agonist therapy, pituitary surgery, radiotherapy, and even chemotherapy.

Case Description: A 19-year-old female presented with galactorrhea, primary amenorrhea, and left hemianopsia. Read More

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http://dx.doi.org/10.3389/fendo.2018.00312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997786PMC
June 2018
20 Reads

Schmidt’s syndrome: a difficult diagnosis in the Latin American context

Rev Med Inst Mex Seguro Soc 2018 Mar-Apr;56(2):189-193

Facultad de Ciencias de la Salud, Escuela de Medicina, Departamento de Investigación. Lima, Perú

Background: Schmidt’s syndrome, also known as poliglandular autoimmune syndrome type 2, is a rare disease that has a prevalence between 1.5-4.5 cases per 100 000 inhabitants. Read More

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November 2018
16 Reads

Complete androgen insensitivity syndrome caused by c.1769-1G > C mutation and activation of a cryptic splice acceptor site in the androgen receptor gene.

Steroids 2018 09 31;137:64-69. Epub 2018 May 31.

Center for Prenatal Diagnosis, The First Hospital of Jilin University, Changchun, Jilin 130021, PR China. Electronic address:

Androgen insensitivity syndrome (AIS) is the most common cause of 46,XY disorders of sex development (46,XY DSD). This syndrome is an X-linked recessive genetic disease characterized by resistance to the actions of androgens in an individual with a male karyotype and it is caused by mutations in the androgen receptor (AR) gene. We evaluated two siblings with primary amenorrhea, normal secondary sex characteristics, absence of uterus and ovaries, intra-abdominal testis, and elevated testosterone levels. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.05.012DOI Listing
September 2018
6 Reads

Two rare forms of congenital adrenal hyperplasia, 11β hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations.

Hormones (Athens) 2018 Mar 16;17(1):127-132. Epub 2018 Apr 16.

Department of Endocrinology, Royal Darwin Hospital, Darwin, NT, Australia.

Background: Congenital adrenal hyperplasia (CAH) is a rare autosomal recessive disorder caused by deficiency of various enzymes responsible for adrenal steroidogenesis. 11-Beta-hydroxylase deficiency (11βOHD) and 17-hydroxylase/17,20-lyase deficiency (17OHD) are rare causes of CAH.

Methods/results: We hereby present a 65-year-old man with 11βOHD and a 33-year-old woman with 17OHD. Read More

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http://link.springer.com/10.1007/s42000-018-0006-8
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http://dx.doi.org/10.1007/s42000-018-0006-8DOI Listing
March 2018
8 Reads

Exercise and chemotherapy-induced amenorrhea.

Med Hypotheses 2018 Jul 25;116:49-53. Epub 2018 Apr 25.

Penn State Cancer Institute, Room T3427, Penn State College of Medicine, Mail Code CH69, 500 University Drive, Hershey, PA 17033, United States. Electronic address:

Chemotherapy-induced amenorrhea (CIA) is the temporary or permanent loss of menses experienced by premenopausal women undergoing chemotherapy treatment for cancer. Two possible mechanisms through which chemotherapy induces CIA have been identified: systemic endothelial dysfunction, resulting in decreased blood flow to the ovaries, and increased oxidative stress within the ovaries, both of which are proposed to lead to apoptosis of follicles. Endothelial dysfunction in ovarian arteries in women undergoing or who have undergone chemotherapy treatment is characterized by prothrombotic changes and thickening of the vascular wall. Read More

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http://dx.doi.org/10.1016/j.mehy.2018.04.022DOI Listing
July 2018
4 Reads

Irreversible Primary Amenorrhea Secondary to Uterine Damage and Premature Ovarian Failure in 2 Patients with Ewing Sarcoma.

J Pediatr Adolesc Gynecol 2018 Dec 29;31(6):648-650. Epub 2018 May 29.

The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

Background: The long-term morbidity of childhood cancer survivors is an emerging field as more patients are now expected to live through adulthood.

Case: We describe 2 adolescent patients with permanent premature ovarian failure and failure of endometrium to respond to estrogen after they received a combination of chemotherapy and pelvic radiation for metastatic Ewing sarcoma. Both girls were prepubertal at diagnosis of Ewing sarcoma. Read More

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http://dx.doi.org/10.1016/j.jpag.2018.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341470PMC
December 2018
13 Reads

Nonfunctioning Pituitary Adenoma That Changed to a Functional Gonadotropinoma.

Case Rep Endocrinol 2018 29;2018:5027859. Epub 2018 Apr 29.

Endocrinology and Metabolism Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Mexico.

Objective: Pituitary adenomas can be classified as clinically functional or silent. Depending on the reviewed literature, these are the first or second place in frequency of the total pituitary adenomas. Even rarer is the presence of a functional gonadotropinoma since only very few case reports exist to date. Read More

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http://dx.doi.org/10.1155/2018/5027859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949168PMC
April 2018
8 Reads

Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome.

Cochrane Database Syst Rev 2018 05 24;5:CD010287. Epub 2018 May 24.

Department of Obstetrics and Gynaecology, University Hospital Münster, Albert-Schweitzer-Campus 1, Münster, Germany, 48149.

Background: Polycystic ovary syndrome (PCOS) is the most common cause of infrequent periods (oligomenorrhoea) and absence of periods (amenorrhoea). It affects about 4% to 8% of women worldwide and often leads to anovulatory subfertility. Aromatase inhibitors (AIs) are a class of drugs that were introduced for ovulation induction in 2001. Read More

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http://doi.wiley.com/10.1002/14651858.CD010287.pub3
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http://dx.doi.org/10.1002/14651858.CD010287.pub3DOI Listing
May 2018
15 Reads