2,733 results match your criteria Amenorrhea Secondary

Pituitary apoplexy of a giant prolactinoma during pregnancy.

Gynecol Endocrinol 2021 Jun 14:1-4. Epub 2021 Jun 14.

Endocrinology and Diabetes Department, Farhat Hached University Hospital of Sousse, Sousse, Tunisia.

Aims And Methods: Prolactinomas are a common cause of sexual dysfunction and infertility. We aimed, through this case report, to illustrate the difficulties of management of women with giant prolactinoma, especially in cases of desire of pregnancy.

Results: A 30-year-old woman was referred to our department for secondary amenorrhea. Read More

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Bone parameters of elite athletes with oligomenorrhea and prevalence seeking medical attention: a cross-sectional study.

J Bone Miner Metab 2021 Jun 8. Epub 2021 Jun 8.

Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama, 359-1192, Japan.

Introduction: Since the definition of secondary amenorrhea is cessation of regular menses for more than 3 months, it is likely that athletes with irregular menstrual cycles, including oligomenorrhea, do not consider the condition as serious. However, the consequences of untreated oligomenorrhea have not been investigated in elite track and field athletes.

Materials And Methods: The cohort consisted of 91 elite-level track and field athletes. Read More

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Next Generation Sequencing Should Be Proposed to Every Woman With "Idiopathic" Primary Ovarian Insufficiency.

J Endocr Soc 2021 Jul 1;5(7):bvab032. Epub 2021 Mar 1.

Sorbonne University Medicine, Paris, France.

Context: Primary ovarian insufficiency (POI) affects 1% of women under 40 years of age. POI is idiopathic in more than 70% of cases. Though many candidate genes have been identified in recent years, the prevalence and pathogenicity of abnormalities are still difficult to establish. Read More

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Massive hemoperitoneum without peritoneal signs: An unusual presentation of omental ectopic rupture. A case report.

Case Rep Womens Health 2021 Jul 15;31:e00327. Epub 2021 May 15.

West Virginia University School of Medicine, United States of America.

Background: Extrauterine ectopic pregnancy is a rare form of ectopic pregnancy, accounting for roughly 1:10,000-30,000 of all pregnancies. Primary omental pregnancy is the least common form of abdominal ectopic pregnancies, making it extremely rare. Typical presentation includes pelvic pain, secondary amenorrhea, with or without vaginal bleeding. Read More

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Anorexia nervosa: COVID-19 pandemic period (Review).

Exp Ther Med 2021 Aug 26;22(2):804. Epub 2021 May 26.

Department of Endocrinology, Clinical County Hospital, 400000 Cluj-Napoca, Romania.

Anorexia nervosa is an eating disorder characterized by restrictive eating and an intense fear of gaining weight. It is a disease with an increasing incidence during the last few decades, and represents a complex psychiatric condition which includes secondary amenorrhea, nutritional and metabolic damage, and impaired endocrine panel up to bone loss as well as cardiac, gastrointestinal and hematological complications. This is a narrative review which includes an update on this eating disorder from the perspective of an endocrine panel of anomalies, especially of the skeleton, considering the pressure of the recent global COVID-19 pandemic changes. Read More

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Utilization of in vitro maturation in cases with a FSH receptor mutation.

J Assist Reprod Genet 2021 Jun 4. Epub 2021 Jun 4.

Department of Gyneacology, Obstetrics and Reproductive Medicine, Hospital Foch, 92150, Suresnes, France.

Purpose: To identify the FSH receptor (FSHR) variant and efficacy of in vitro maturation (IVM) in a 28-year-old woman with secondary amenorrhea, primary infertility, and ovarian resistance to FSH, and to analyze the genotype-to-phenotype relationship in cases of FSHR mutation for the development of an IVM algorithm for use in patients with gonadotropin resistance syndrome (GRS).

Methods: Oocytes retrieved after menstruation induction with norethisterone, followed by daily estrogen and an ovulatory trigger, underwent IVM, ICSI, and culture in a time-lapse (TL) incubator. Embryo transfers were performed on day 2, and after thawing on day 5. Read More

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Functional and Reproductive Outcomes Following Surgical Management of Congenital Anomalies of the Cervix: A Systematic Review.

J Minim Invasive Gynecol 2021 May 28. Epub 2021 May 28.

Department of Obstetrics & Gynecology, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki Greece.

Objective: The purpose of this systematic review was to evaluate surgical treatment for malformations of the cervix in terms of short- and long-term postoperative function and relevant reproductive outcomes.

Data Sources: PROSPERO (ID No CRD42019128899). Electronic databases were searched for eligible studies up to October 2019 on Medline/PubMed (1966-2019), Scopus/Elsevier (1950-2019), and Google Scholar (up to 2019). Read More

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11-oxygenated androgens and their relation to hypothalamus-pituitary-gonadal-axis disturbances in adults with congenital adrenal hyperplasia.

J Steroid Biochem Mol Biol 2021 May 28;212:105921. Epub 2021 May 28.

Medizinische Klinik and Poliklinik IV, Klinikum der Universität München, LMU München, Munich, Germany. Electronic address:

Context: Hypothalamus-pituitary-gonadal (HPG)-axis disturbances are a common phenomenon in patients with classic congenital adrenal hyperplasia (CAH). 11-oxygenated androgens have been suggested to play a role in this context.

Design: Cross-sectional single center study including 89 patients (N = 42 men, N = 55 women) with classic CAH. Read More

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Avascular femoral necrosis as part of Cushing syndrome presentation: a case report.

J Med Case Rep 2021 May 26;15(1):287. Epub 2021 May 26.

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, 4200-319, Porto, Portugal.

Background: The clinical characteristics and complications of Cushing syndrome (CS) are well known and described in the literature. Nevertheless, rare, atypical presentations may go unnoticed. Osteonecrosis is a well-documented complication of glucocorticoid therapy. Read More

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[Preoperative treatment of uterine fibroids with low-dose mifepristone: a multicenter, randomized, double-blind, placebo-controlled, parallel-group study].

Zhonghua Fu Chan Ke Za Zhi 2021 May;56(5):317-327

Department of Biostatistics, Peking University First Hospital, Beijing 100034, China.

To evaluate the clinical efficacy and safety of oral mifepristone (10 mg/day) versus placebo in the preoperative treatment of uterine fibroids. This study was a multi-center, randomized, double-blind, placebo, parallel controlled trial. A total of 132 patients with uterine fibroids were randomly divided into study group and control group, with 66 cases in each group. Read More

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Non-functioning pituitary adenomas and pregnancy: one-center experience and review of the literature.

Arch Endocrinol Metab 2021 May;64(5):614-622

División Endocrinología, Hospital General de Agudos Dr. Carlos G. Durand, Buenos Aires, Argentina.

The usual clinical presentation of non-functioning pituitary adenoma (NFPA) consists of symptoms of mass effect and hypopituitarism. NFPA is a rare condition in young women and an uncommon complication during pregnancy. We present the outcome of three patients with NFPA during pregnancy. Read More

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Successful live birth after maturation treatment in a patient with autoimmune premature ovarian failure: a case report and review of the literature.

Gynecol Endocrinol 2021 May 19:1-5. Epub 2021 May 19.

Service de Biologie De la Reproduction-CECOS, Centre Aliénor d'Aquitaine, Bordeaux, France.

Objective: We report a successful live birth after oocytes maturation (IVM) and fresh embryo transfer in a patient with autoimmune premature ovarian failure (POF) and performed a review of the literature of livebirths obtained after oocytes IVM treatment in this indication.

Methods: The patient was a 24-year-old woman with autoimmune POF diagnosed post-partum, who developed autoimmune polyglandular syndrome with serum anti-ovarian and anti-21-hydroxylase antibodies. The patient had typical symptoms of POF: secondary amenorrhea with hypoestrogenism, elevated gonadotropins and infertility; however, the serum anti-Müllerian hormone level and total antral follicle count remained normal. Read More

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Ayurvedic management of female infertility due to tubal blockage.

J Complement Integr Med 2021 May 12. Epub 2021 May 12.

Amrita School of Ayurveda, Amrita Viswavidyapeetham, Kollam, India.

Objectives: Secondary Infertility is a major concern worldwide, accounting for about 40% of female infertility due to lifestyle factor. Secondary Infertility is having a close proximity to a disorder explained in Ayurvedic classics, due to a variety of causes. Several Ayurvedic interventions are advised such as (∼purification therapy) for vitiated in female reproductive organs, (∼oral intake of medicated oil) followed by (∼purgation) to produce quality ovum. Read More

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Apoplexy of Crooke cell tumour leading to the diagnosis of severe Cushing disease; a case report.

BMC Endocr Disord 2021 May 1;21(1):93. Epub 2021 May 1.

Neurosurgical Unit, National Hospital of Sri Lanka, Colombo 10, Sri Lanka.

Background: Patients with Crooke cell tumours present with features of Cushing syndrome or mass effect. There are few reports of patients with Crooke cell tumours presenting due to apoplexy. All of them had silent tumours. Read More

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Pseudocyesis Leading to Folie-à-Deux.

J Neurosci Rural Pract 2021 Apr 24;12(2):419-423. Epub 2021 Mar 24.

Department of Psychiatry, Jawaharlal Nehru Medical College, Sawangi, Wardha, Maharashtra, India.

Pseudocyesis or false belief of pregnancy is the emergence of classical manifestations of pregnancy-nausea, breast enlargement and pigmentation, abdominal distention, amenorrhea, and labor pains-in a nonpregnant woman. It is a multifactorial disease and its development is influenced by many different elements such as neuroendocrine, social, psychodynamic, and cultural issues. "Folie-à-deux," is shared psychotic disorder, describes a syndrome in which delusion is transferred to another person who is more susceptible. Read More

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Relationships between hormonal parameters, body fat distribution and bone mineral density in women with functional menstrual disorders.

Ginekol Pol 2021 Apr 29. Epub 2021 Apr 29.

Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University, Szczecin, Poland.

Objectives: Available evidence implies that unfavorable changes in the distribution of adipose tissue resulting from hormonal imbalance associated with ovarian insufficiency might influence bone mineral density (BMD). The purpose of our study was to verify if volumes of visceral (VAT), female (FAT) and android (AAT) body fat as determined by densitometry determined influence BMD in women with functional menstrual disorders, and if these correlates some endocrine factors.

Material And Methods: We examined 293 women (mean age 26. Read More

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Laparoscopic Davydov's Colpopoiesis for a Case of Mayer-Rokitansky-Kuster-Hauser (MRKH) Syndrome.

Cureus 2021 Mar 18;13(3):e13974. Epub 2021 Mar 18.

Obstetrics and Gynaecology, Prathima Institute of Medical Sciences, Karimnagar, IND.

Congenital absence of vagina and uterus has been eponymously called Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. The vagina may appear as a dimple with the presence of rudimentary uterine primordia and normal functioning ovaries. Its incidence is 1 in 4500 to 5000 female. Read More

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Menstrual patterns and disorders among Chinese women of reproductive age: A cross-sectional study based on mobile application data.

Medicine (Baltimore) 2021 Apr;100(16):e25329

Department of Obstetrics and Gynecology, Peking University Ninth School of Clinical Medicine, Beijing Shijitan Hospital, Capital Medical University.

Abstract: Menstruation is an important indicator of women's health. Identification of abnormal menstrual patterns in adolescence may improve early diagnosis of potential health concerns in adulthood. This study aimed to evaluate menstrual patterns and disorders of Chinese women of reproductive age based on an APP. Read More

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A Nonfunctioning Pituitary Macroadenoma Presenting as Cyclical Vomiting and Severe Hyponatremia in a Young Female.

Case Rep Endocrinol 2021 31;2021:5570539. Epub 2021 Mar 31.

Sri Jayewardenepura General Hospital, Nugegoda, Colombo, Sri Lanka.

Introduction: Recurrent vomiting is a commonly overlooked debilitating symptom which causes significant impact on the quality of life. There are several causes for vomiting, ranging from commonly known causes to rare causes. Nonfunctioning pituitary macroadenomas generally present with visual disturbances, headache, and symptoms due to anterior pituitary hormone deficiencies. Read More

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A Case of Burnt-Out Langerhans Cell Histiocytosis Presenting as Postpartum Hypopituitarism.

AACE Clin Case Rep 2021 Jan-Feb;7(1):47-50. Epub 2020 Dec 28.

Department of Endocrinology, Townsville University Hospital, Douglas, Queensland, Australia.

Objective: To evaluate the case of a woman who presented with central hypogonadism and diabetes insipidus and further developed a persistent cough leading to an unexpected diagnosis of burnt-out Langerhans cell histiocytosis (LCH).

Methods: Clinical and laboratory endocrine evaluation, magnetic resonance imaging, high-resolution computed tomography, and open-lung biopsy results are discussed.

Results: A 28-year-old woman presented at 10 months postpartum with polydipsia, polyuria, and amenorrhea for 3 months. Read More

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December 2020

Preparing for Puberty in Girls With Special Needs: A Cohort Study of Caregiver Concerns and Patient Outcomes.

J Pediatr Adolesc Gynecol 2021 Apr 7. Epub 2021 Apr 7.

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.

Study Objective: To characterize the patient population with cognitive or physical impairments that presents for anticipatory guidance of puberty, evaluate caregiver concerns with respect to puberty, and describe chosen management strategies and outcomes following menarche.

Design: Retrospective cohort study SETTING: Academic tertiary care women and children's hospital PARTICIPANTS: Eligible female patients with special needs up to age 26 years presenting for anticipatory guidance from 2009 to 2018 MAIN OUTCOME MEASURES: Primary outcomes included characterization of patients presenting for anticipatory guidance and their reasons for menstrual management. Secondary outcomes were satisfaction with menstrual management and bleeding patterns. Read More

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Physical Activity, Menstrual History, and Bone Microarchitecture in Female Athletes with Multiple Bone Stress Injuries.

Med Sci Sports Exerc 2021 Apr 7. Epub 2021 Apr 7.

Massachusetts General Hospital, Boston, MA United States Army Research Institute of Environmental Medicine, Natick MA Harvard Medical School, Boston MA Spaulding Rehabilitation Hospital, Cambridge MA Boston Children's Hospital, Boston MA Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA.

Bone stress injuries (BSIs) occur in up to 20% of runners and military recruits and those with a history of BSI have a 5-fold higher risk for a subsequent BSI. Yet, little is known about prior training, menstrual status and bone structure in runners who experience multiple BSIs.

Purpose: To determine differences in health and physical activity history, bone density, microarchitecture, and strength among female athletes with a history of multiple BSI, athletes with ≤1 BSI, and non-athletes. Read More

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Clinical outcome and analysis of procedural failure during uterine artery chemoembolisation as a treatment of caesarean scar pregnancy.

Wideochir Inne Tech Maloinwazyjne 2021 Mar 9;16(1):243-248. Epub 2020 Nov 9.

Department of Gynaecology, Medical University of Lublin, Lublin, Poland.

Introduction: Caesarean scar pregnancy (CSP) is a relatively rare yet life-threatening condition in which the embryo is implanted in the scar after caesarean section. Recent studies have reported that uterine artery chemoembolisation (UAC) can be safe and effective method in treating CSP.

Aim: To present the clinical outcome of UAC with a mixture of methotrexate and gelatine sponge for the treatment of CSP and analysis of procedural failure. Read More

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A Novel Technique for the Reconstructive Formation of an Annular Hymen in Cases of Postpubertal Imperforate Hymen.

Atef M Darwish

Sultan Qaboos Univ Med J 2021 Feb 15;21(1):e110-e115. Epub 2021 Mar 15.

Department of Obstetrics & Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Objectives: Imperforate hymen (IH) is a common genital tract anomaly in women which usually presents after puberty. However, surgical treatment is often considered controversial in religious or conservative communities for sociocultural reasons. This study therefore aimed to assess the efficacy of a novel reconstructive technique involving the preservation of the annular hymen. Read More

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February 2021

Delayed Identification of Adolescent Adrenal Cortical Carcinoma Initially Diagnosed as Polycystic Ovary Syndrome.

J Pediatr Adolesc Gynecol 2021 Mar 26. Epub 2021 Mar 26.

Department of Thoracic Surgery, Capital Institute of Pediatrics, Beijing, China.

Background: Adrenocortical carcinoma is a rare, isolated malignancy.

Case: A 13-year-old girl presented with secondary amenorrhea, hirsutism, and hypertension. Her clinical manifestations were interpreted as polycystic ovary syndrome and hyperinsulinemia. Read More

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Multidisciplinary team management of 46,XY 17α-hydroxylase deficiency: a case report and literature review.

J Int Med Res 2021 Mar;49(3):300060521993965

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Background: We report here a case study of 17α-hydroxylase deficiency in a phenotypic girl with male karyotype (46,XY). We also review the relevant literature to deepen our understanding of the disease, reduce the rate of missed diagnosis, and emphasize that holistic management of this disease requires collaborative multidisciplinary teamwork.

Case Presentation: A 14-year-old patient with a female phenotype visited the endocrinology department because of hypertension. Read More

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Vesicouterine fistula presenting with cyclical haematuria mimicking bladder endometriosis: A case report.

Int J Surg Case Rep 2021 Mar 25;80:105709. Epub 2021 Feb 25.

Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Vesicouterine fistula (VUF) is an abnormal communication between the bladder and uterus, occurring 1-4% of all urogenital fistulas. Diagnosis is still a challenge because symptoms may appear late or fistula may be missed even after repeated examination. A 37-year old woman who has two children born through caesarean section complained of the absence of menstruation for the past three years. Read More

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Treatment-related fertility impairment in long-term female childhood, adolescent and young adult cancer survivors: investigating dose-effect relationships in a European case-control study (PanCareLIFE).

Hum Reprod 2021 05;36(6):1561-1573

Department of Paediatrics, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Study Question: Which chemotherapeutic agents and body site-specific radiation fields are dose-dependently associated with an increased risk of fertility impairment in long-term female childhood, adolescent and young adulthood (CAYA) cancer survivors?

Summary Answer: Busulfan, lower abdominal radiotherapy (RT) and total body irradiation (TBI) seem to be associated with fertility impairment at any dose, whereas gonadotoxicity of melphalan and procarbazine is suggested at medium/high (>140 mg/m2) or high dose (>5600 mg/m2) therapy, respectively.

What Is Known Already: Several treatment-related fertility deficits, as assessed by both self-reported outcomes and hormonal markers are known to occur following treatment of CAYA cancer. However, knowledge regarding precise dose-related estimates of these treatment-related risks are scarce. Read More

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Current Understanding of the Etiology, Symptomatology, and Treatment Options in Premature Ovarian Insufficiency (POI).

Bunpei Ishizuka

Front Endocrinol (Lausanne) 2021 25;12:626924. Epub 2021 Feb 25.

Rose Ladies Clinic, Tokyo, Japan.

Premature ovarian insufficiency (POI) occurs in at least 1% of all women and causes life-long health problems and psychological stress. Infertility caused by POI used to be considered absolute, with infertility treatment having little or no value. Generally, it has been thought that medicine can provide little service to these patients. Read More

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February 2021